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16 results on '"Britt, Jeremiah"'

1. Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Author

Wang, Jieqi, Wegener, Jan Eike, Huang, Teng-Wei, Sripathy, Smitha, De Jesus-Cortes, Hector, Xu, Pin, Tran, Stephanie, Knobbe, Whitney, Leko, Vid, Britt, Jeremiah, Starwalt, Ruth, McDaniel, Latisha, Ward, Chris S, Parra, Diana, Newcomb, Benjamin, Lao, Uyen, Nourigat, Cynthia, Flowers, David A, Cullen, Sean, Jorstad, Nikolas L, Yang, Yue, Glaskova, Lena, Vigneau, Sébastien, Kozlitina, Julia, Yetman, Michael J, Jankowsky, Joanna L, Reichardt, Sybille D, Reichardt, Holger M, Gärtner, Jutta, Bartolomei, Marisa S, Fang, Min, Loeb, Keith, Keene, C Dirk, Bernstein, Irwin, Goodell, Margaret, Brat, Daniel J, Huppke, Peter, Neul, Jeffrey L, Bedalov, Antonio, and Pieper, Andrew A

Subjects
General Science & Technology
Published
2015

2. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.

Author

Wang, Jieqi, Wegener, Jan Eike, Huang, Teng-Wei, Sripathy, Smitha, De Jesus-Cortes, Hector, Xu, Pin, Tran, Stephanie, Knobbe, Whitney, Leko, Vid, Britt, Jeremiah, Starwalt, Ruth, McDaniel, Latisha, Ward, Chris S, Parra, Diana, Newcomb, Benjamin, Lao, Uyen, Nourigat, Cynthia, Flowers, David A, Cullen, Sean, Jorstad, Nikolas L, Yang, Yue, Glaskova, Lena, Vingeau, Sébastien, Kozlitina, Julia, Yetman, Michael J, Jankowsky, Joanna L, Reichardt, Sybille D, Reichardt, Holger M, Gärtner, Jutta, Bartolomei, Marisa S, Fang, Min, Loeb, Keith, Keene, C Dirk, Bernstein, Irwin, Goodell, Margaret, Brat, Daniel J, Huppke, Peter, Neul, Jeffrey L, Bedalov, Antonio, and Pieper, Andrew A

Subjects
Microglia, Animals, Rett Syndrome, Disease Progression, Female, Male, Methyl-CpG-Binding Protein 2, General Science & Technology
Published
2015

6. Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice

Author

Broussard, John I, primary, Acion, Laura, additional, De Jesús-Cortés, Héctor, additional, Yin, Terry, additional, Britt, Jeremiah K, additional, Salas, Ramiro, additional, Costa-Mattioli, Mauro, additional, Robertson, Claudia, additional, Pieper, Andrew A, additional, Arciniegas, David B, additional, and Jorge, Ricardo, additional

Published
2017
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7. Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice

Author

Yin, Terry C., primary, Voorhees, Jaymie R., additional, Genova, Rachel M., additional, Davis, Kevin C., additional, Madison, Ashley M., additional, Britt, Jeremiah K., additional, Cintrón-Pérez, Coral J., additional, McDaniel, Latisha, additional, Harper, Matthew M., additional, and Pieper, Andrew A., additional

Published
2016
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8. The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons

Author

Lee, Anni S., primary, De Jesús-Cortés, Héctor, additional, Kabir, Zeeba D., additional, Knobbe, Whitney, additional, Orr, Madeline, additional, Burgdorf, Caitlin, additional, Huntington, Paula, additional, McDaniel, Latisha, additional, Britt, Jeremiah K., additional, Hoffmann, Franz, additional, Brat, Daniel J., additional, Rajadhyaksha, Anjali M., additional, and Pieper, Andrew A., additional

Published
2016
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9. Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice.

Author

Broussard, John I, Acion, Laura, De Jesús-Cortés, Héctor, Yin, Terry, Britt, Jeremiah K, Salas, Ramiro, Costa-Mattioli, Mauro, Robertson, Claudia, Pieper, Andrew A, Arciniegas, David B, and Jorge, Ricardo

Subjects
COGNITION disorder risk factors, POST-traumatic stress disorder, MOTOR ability, BRAIN injuries, AFFECTIVE disorders, MEMORY disorders, ANXIETY risk factors, ANIMAL experimentation, INFLAMMATION, MICE, DISEASE risk factors, MENTAL illness risk factors, PSYCHOLOGY
Abstract

Primary Objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. Research Design: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group. Methods and Procedures: We assessed the effects of smTBI and rmTBI using measures of motor performance (Rotarod Test [RT]), anxiety-like behaviour (Elevated Plus Maze [EPM] and Open Field [OF] tests), and spatial memory (Morris Water Maze [MWM]) within 12 days of the final injury. In separate groups of mice, astrocytosis and microglial activation were assessed 24 hours after the final injury using GFAP and IBA-1 immunohistochemistry. Main Outcomes and Results: RmTBI impaired spatial memory in the MWM and increased anxiety-like behaviour in the EPM and OFT. In addition, rmTBI elevated GFAP and IBA-1 immunohistochemistry throughout the mouse brain. RmTBI produced astrocytosis and microglial activation, and elicited impaired spatial memory and anxiety-like behaviour. Conclusions: rmTBI produces acute cognitive and anxiety-like disturbances associated with inflammatory changes in brain regions involved in spatial memory and anxiety. [ABSTRACT FROM PUBLISHER]

Published
2018
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10. Erratum: Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Author

Wang, Jieqi, primary, Wegener, Jan Eike, additional, Huang, Teng-Wei, additional, Sripathy, Smitha, additional, De Jesus-Cortes, Hector, additional, Xu, Pin, additional, Tran, Stephanie, additional, Knobbe, Whitney, additional, Leko, Vid, additional, Britt, Jeremiah, additional, Starwalt, Ruth, additional, McDaniel, Latisha, additional, Ward, Chris S., additional, Parra, Diana, additional, Newcomb, Benjamin, additional, Lao, Uyen, additional, Nourigat, Cynthia, additional, Flowers, David A., additional, Cullen, Sean, additional, Jorstad, Nikolas L., additional, Yang, Yue, additional, Glaskova, Lena, additional, Vigneau, Sébastien, additional, Kozlitina, Julia, additional, Yetman, Michael J., additional, Jankowsky, Joanna L., additional, Reichardt, Sybille D., additional, Reichardt, Holger M., additional, Gärtner, Jutta, additional, Bartolomei, Marisa S., additional, Fang, Min, additional, Loeb, Keith, additional, Keene, C. Dirk, additional, Bernstein, Irwin, additional, Goodell, Margaret, additional, Brat, Daniel J., additional, Huppke, Peter, additional, Neul, Jeffrey L., additional, Bedalov, Antonio, additional, and Pieper, Andrew A., additional

Published
2015
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11. Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease

Author

De Jesús-Cortés, Héctor, primary, Miller, Adam D, additional, Britt, Jeremiah K, additional, DeMarco, Anthony J, additional, De Jesús-Cortés, Mayralis, additional, Stuebing, Emily, additional, Naidoo, Jacinth, additional, Vázquez-Rosa, Edwin, additional, Morlock, Lorraine, additional, Williams, Noelle S, additional, Ready, Joseph M, additional, Narayanan, Nandakumar S, additional, and Pieper, Andrew A, additional

Published
2015
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12. P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

Author

Yin, Terry C., primary, Britt, Jeremiah K., additional, De Jesús-Cortés, Héctor, additional, Lu, Yuan, additional, Genova, Rachel M., additional, Khan, Michael Z., additional, Voorhees, Jaymie R., additional, Shao, Jianqiang, additional, Katzman, Aaron C., additional, Huntington, Paula J., additional, Wassink, Cassie, additional, McDaniel, Latisha, additional, Newell, Elizabeth A., additional, Dutca, Laura M., additional, Naidoo, Jacinth, additional, Cui, Huxing, additional, Bassuk, Alexander G., additional, Harper, Matthew M., additional, McKnight, Steven L., additional, Ready, Joseph M., additional, and Pieper, Andrew A., additional

Published
2014
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13. PRICKLE1 Interaction with SYNAPSIN I Reveals a Role in Autism Spectrum Disorders

Author

Paemka, Lily, primary, Mahajan, Vinit B., additional, Skeie, Jessica M., additional, Sowers, Levi P., additional, Ehaideb, Salleh N., additional, Gonzalez-Alegre, Pedro, additional, Sasaoka, Toshikuni, additional, Tao, Hirotaka, additional, Miyagi, Asuka, additional, Ueno, Naoto, additional, Takao, Keizo, additional, Miyakawa, Tsuyoshi, additional, Wu, Shu, additional, Darbro, Benjamin W., additional, Ferguson, Polly J., additional, Pieper, Andrew A., additional, Britt, Jeremiah K., additional, Wemmie, John A., additional, Rudd, Danielle S., additional, Wassink, Thomas, additional, El-Shanti, Hatem, additional, Mefford, Heather C., additional, Carvill, Gemma L., additional, Manak, J. Robert, additional, and Bassuk, Alexander G., additional

Published
2013
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14. Discovery of a Proneurogenic, Neuroprotective Chemical

Author

Pieper, Andrew A., primary, Xie, Shanhai, additional, Capota, Emanuela, additional, Estill, Sandi Jo, additional, Zhong, Jeannie, additional, Long, Jeffrey M., additional, Becker, Ginger L., additional, Huntington, Paula, additional, Goldman, Shauna E., additional, Shen, Ching-Han, additional, Capota, Maria, additional, Britt, Jeremiah K., additional, Kotti, Tiina, additional, Ure, Kerstin, additional, Brat, Daniel J., additional, Williams, Noelle S., additional, MacMillan, Karen S., additional, Naidoo, Jacinth, additional, Melito, Lisa, additional, Hsieh, Jenny, additional, De Brabander, Jef, additional, Ready, Joseph M., additional, and McKnight, Steven L., additional

Published
2010
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15. Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.

Author

Pin Xu, Grueter, Brad A., Britt, Jeremiah K., McDaniel, Latisha, Huntington, Paula J., Hodge, Rachel, Tran, Stephanie, Mason, Brittany L., Lee, Charlotte, Vong, Linh, Lowell, Bradford B., Malenka, Robert C., Lutter, Michael, and Pieper, Andrew A.

Subjects
COMPULSIVE behavior, NEUROBEHAVIORAL disorders, OBSESSIVE-compulsive disorder, EATING disorders, AUTISM, MELANOCORTIN receptors
Abstract

Compulsive behavior is a debilitating clinical feature of many forms of neuropsychiatric disease, including Tourette syndrome, obsessive-compulsive spectrum disorders, eating disorders, and autism. Although several studies link striatal dysfunction to compulsivity, the pathophysiology remains poorly understood. Here, we show that both constitutive and induced genetic deletion of the gene encoding the melanocortin 4 receptor (MC4R), as well as pharmacologic inhibition of MC4R signaling, normalize compulsive grooming and striatal electrophysiologic impairments in synapse-associated protein 90/postsynaptic density protein 95-associated protein 3 (SAPAP3)-null mice, a model of human obsessive-compulsive disorder. Unexpectedly, genetic deletion of SAPAP3 restores normal weight and metabolic features of MC4R-null mice, a model of human obesity. Our findings offer insights into the pathophysiology and treatment of both compulsive behavior and eating disorders. [ABSTRACT FROM AUTHOR]

Published
2013
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16. Ca 2+ -Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity.

Author

Yang T, Britt JK, Cintrón-Pérez CJ, Vázquez-Rosa E, Tobin KV, Stalker G, Hardie J, Taugher RJ, Wemmie J, Pieper AA, and Lee A

Subjects
Animals, Mice, Mice, Inbred C57BL, Mice, Knockout, Calcium-Binding Proteins metabolism, Hippocampus physiology, Long-Term Potentiation physiology, Memory physiology, Spatial Learning physiology
Abstract

Ca 2+ -binding protein 1 (CaBP1) is a Ca 2+ -sensing protein similar to calmodulin that potently regulates voltage-gated Ca 2+ channels. Unlike calmodulin, however, CaBP1 is mainly expressed in neuronal cell-types and enriched in the hippocampus, where its function is unknown. Here, we investigated the role of CaBP1 in hippocampal-dependent behaviors using mice lacking expression of CaBP1 (C-KO). By western blot, the largest CaBP1 splice variant, caldendrin, was detected in hippocampal lysates from wild-type (WT) but not C-KO mice. Compared to WT mice, C-KO mice exhibited mild deficits in spatial learning and memory in both the Barnes maze and in Morris water maze reversal learning. In contextual but not cued fear-conditioning assays, C-KO mice showed greater freezing responses than WT mice. In addition, the number of adult-born neurons in the hippocampus of C-KO mice was ∼40% of that in WT mice, as measured by bromodeoxyuridine labeling. Moreover, hippocampal long-term potentiation was significantly reduced in C-KO mice. We conclude that CaBP1 is required for cellular mechanisms underlying optimal encoding of hippocampal-dependent spatial and fear-related memories., (Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2018
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