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Your search keyword '"Brito, Marcello R."' showing total 2 results
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2 results on '"Brito, Marcello R."'

1. Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis

Author

Marques, Bruno L., primary, Maciel, Giovana Figueiredo, additional, Brito, Marcello R., additional, Dias, Lucas D., additional, Scalzo, Sérgio, additional, Santos, Anderson K., additional, Kihara, Alexandre Hiroaki, additional, da Costa Santiago, Helton, additional, Parreira, Ricardo C., additional, Birbrair, Alexander, additional, and Resende, Rodrigo R., additional

Published
2022
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2. Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis.

Author

Marques, Bruno L., Maciel, Giovana Figueiredo, Brito, Marcello R., Dias, Lucas D., Scalzo, Sérgio, Santos, Anderson K., Kihara, Alexandre Hiroaki, da Costa Santiago, Helton, Parreira, Ricardo C., Birbrair, Alexander, and Resende, Rodrigo R.

Subjects
*CELL differentiation, *STEM cells, *NEURAL stem cells, *NEUROGENESIS, *EXTRACELLULAR matrix, *DEVELOPMENTAL neurobiology, *OLD age
Abstract

The world population's life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, microRNAs, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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