Search

Your search keyword '"Brito, Catarina"' showing total 457 results
Start Over Author "Brito, Catarina"
457 results on '"Brito, Catarina"'

1. START NOW WebApp—promoting emotion regulation and resilience in residential youth care and correctional institutions: study protocol for a cluster randomized controlled trial

Author

Kersten, Linda, Alfano, Janine, Erlanger, Tobias E., Helfenstein, Fabrice, Lanz, Lelia, Weiss, Stefan, Chilla, Chiara, von Planta, Beryll, Kapoor, Madlaina, Borel, Nathalie, Rocco, Tabea, Papageorgiou, Andreas, De Brito, Catarina Fernandes, Bajrami, Arzie, Savary, Valentine, Mayor, Melanie, Hurschler, Jana, Traut, Alex, Brunner, Donja, Vriends, Noortje, and Stadler, Christina

Published
2024
Full Text
View/download PDF

3. Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Author

Carecho, Rafael, Figueira, Inês, Terrasso, Ana Paula, Godinho‐Pereira, Joana, de Oliveira Sequeira, Catarina, Pereira, Sofia Azeredo, Milenkovic, Dragan, Leist, Marcel, Brito, Catarina, and dos Santos, Cláudia Nunes

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Neurosciences, Parkinson's Disease, Aging, Prevention, Neurodegenerative, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Humans, Parkinson Disease, Phenol, Neuroprotection, 1-Methyl-4-phenylpyridinium, Dopaminergic Neurons, Sulfates, Neuroprotective Agents, dopaminergic neurons, gene expression, neurodegeneration, preconditioning, transcriptomics, Food Sciences, Nutrition and Dietetics, Public Health and Health Services, Food Science, Nutrition & Dietetics, Food sciences, Nutrition and dietetics
Abstract

ScopeDiets rich in (poly)phenols have been associated with positive effects on neurodegenerative disorders, such as Parkinson's disease (PD). Several low-molecular weight (poly)phenol metabolites (LMWPM) are found in the plasma after consumption of (poly)phenol-rich food. It is expected that LMWPM, upon reaching the brain, may have beneficial effects against both oxidative stress and neuroinflammation, and possibly attenuate cell death mechanisms relate to the loss of dopaminergic neurons in PD.Methods and resultsThis study investigates the neuroprotective potential of two blood-brain barrier permeant LMWPM, catechol-O-sulfate (cat-sulf), and pyrogallol-O-sulfate (pyr-sulf), in a human 3D cell model of PD. Neurospheroids were generated from LUHMES neuronal precursor cells and challenged by 1-methyl-4-phenylpyridinium (MPP+ ) to induce neuronal stress. LMWPM pretreatments were differently neuroprotective towards MPP+ insult, presenting distinct effects on the neuronal transcriptome. Particularly, cat-sulf pretreatment appeared to boost counter-regulatory defense mechanisms (preconditioning). When MPP+ is applied, both LMWPM positively modulated glutathione metabolism and heat-shock response, as also favorably shifting the balance of pro/anti-apoptotic proteins.ConclusionsOur findings point to the potential of LMWPM to trigger molecular mechanisms that help dopaminergic neurons to cope with a subsequent toxic insult. They are promising molecules to be further explored in the context of preventing and attenuating parkinsonian neurodegeneration.

Published
2022

6. Costs for Road Safety of Countering the Automatic Processes of Natural Reading in the Design of Horizontal Road Information

Author

Noriega, Paulo, Vilar, Elisângela, Figueiredo, André, Brito, Catarina, Carvalho, Joana, Rebelo, Francisco, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Rebelo, Francisco, editor

Published
2021
Full Text
View/download PDF

31. PREDECT Protocols for Complex 2D/3D Cultures

Author

Vidic, Suzana, primary, Estrada, Marta F., additional, Gjerde, Kjersti, additional, Santo, Vítor E., additional, Osswald, Annika, additional, Barbier, Michaël, additional, Chong, Yolanda T., additional, Sommergruber, Wolfgang, additional, de Hoogt, Ronald, additional, Brito, Catarina, additional, and Graeser, Ralph, additional

Published
2018
Full Text
View/download PDF

37. Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization

Author

Torán, José Luis, López, Juan Antonio, Gomes-Alves, Patricia, Aguilar, Susana, Torroja, Carlos, Trevisan-Herraz, Marco, Moscoso, Isabel, Sebastião, Maria João, Serra, Margarida, Brito, Catarina, Cruz, Francisco Miguel, Sepúlveda, Juan Carlos, Abad, José Luis, Galán-Arriola, Carlos, Ibanez, Borja, Martínez, Fernando, Fernández, María Eugenia, Fernández-Aviles, Francisco, Palacios, Itziar, R-Borlado, Luis, Vázquez, Jesús, Alves, Paula M., and Bernad, Antonio

Published
2019
Full Text
View/download PDF

45. Neuroprotection in a 3D Cell Model of Parkinson's Disease

Author

Carecho, Rafael, Figueira, Inês, Terrasso, Ana Paula, Godinho-Pereira, Joana, de Oliveira Sequeira, Catarina, Pereira, Sofia Azeredo, Milenkovic, Dragan, Leist, Marcel, Brito, Catarina, Nunes dos Santos, Cláudia, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Instituto de Tecnologia Química e Biológica António Xavier (ITQB), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
SDG 3 - Good Health and Well-being, Biotechnology, Food Science
Abstract

Funding Information: This work was supported by European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program under grant agreement No. 804229; iNOVA4Health – UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. FCT/MCTES, through the project PTDC/BTM‐ORG/29580/2017. Authors would like to acknowledge FCT for financial support of R.C. (PD/BD/135492/2018) and J.G.‐P. (SFRH/BD/145522/2019). M.L. was supported by the Land‐BW (NAM‐ACCEPT) and funding by the European Union's Horizon 2020 research and innovation program under grant agreements No. 964537 (RISK‐HUNT3R), No. 964518 (ToxFree), and No. 825759 (ENDpoiNTs). Publisher Copyright: © 2022 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH Scope: Diets rich in (poly)phenols have been associated with positive effects on neurodegenerative disorders, such as Parkinson's disease (PD). Several low-molecular weight (poly)phenol metabolites (LMWPM) are found in the plasma after consumption of (poly)phenol-rich food. It is expected that LMWPM, upon reaching the brain, may have beneficial effects against both oxidative stress and neuroinflammation, and possibly attenuate cell death mechanisms relate to the loss of dopaminergic neurons in PD. Methods and Results: This study investigates the neuroprotective potential of two blood-brain barrier permeant LMWPM, catechol-O-sulfate (cat-sulf), and pyrogallol-O-sulfate (pyr-sulf), in a human 3D cell model of PD. Neurospheroids were generated from LUHMES neuronal precursor cells and challenged by 1-methyl-4-phenylpyridinium (MPP+) to induce neuronal stress. LMWPM pretreatments were differently neuroprotective towards MPP+ insult, presenting distinct effects on the neuronal transcriptome. Particularly, cat-sulf pretreatment appeared to boost counter-regulatory defense mechanisms (preconditioning). When MPP+ is applied, both LMWPM positively modulated glutathione metabolism and heat-shock response, as also favorably shifting the balance of pro/anti-apoptotic proteins. Conclusions: Our findings point to the potential of LMWPM to trigger molecular mechanisms that help dopaminergic neurons to cope with a subsequent toxic insult. They are promising molecules to be further explored in the context of preventing and attenuating parkinsonian neurodegeneration. publishersversion epub_ahead_of_print

Published
2022

46. Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models

Author

Fontinha, Diana, Arez, Francisca, Gal, Isabella Ramella, Nogueira, Gonçalo, Moita, Diana, Baeurle, Tobias Hyun Ho, Brito, Catarina, Spangenberg, Thomas, Alves, Paula M., Prudêncio, Miguel, and Repositório da Universidade de Lisboa

Subjects
Drug discovery, M5717, Pyronaridine, Combination therapy, Liver stage infection, Malaria
Abstract

Copyright © 2022 The Authors. Published by American Chemical Society, Combination therapies have emerged to mitigate Plasmodium drug resistance, which has hampered the fight against malaria. M5717 is a potent multistage antiplasmodial drug under clinical development, which inhibits parasite protein synthesis. The combination of M5717 with pyronaridine, an inhibitor of hemozoin formation, displays potent activity against blood stage Plasmodium infection. However, the impact of this therapy on liver infection by Plasmodium remains unknown. Here, we employed a recently described 3D culture-based hepatic infection platform to evaluate the activity of the M5717-pyronaridine combination against hepatic infection by P. berghei. This effect was further confirmed in vivo by employing the C57BL/6J rodent Plasmodium infection model. Collectively, our data demonstrate that pyronaridine potentiates the activity of M5717 against P. berghei hepatic development. These preclinical results contribute to the validation of pyronaridine as a suitable partner drug for M5717, supporting the clinical evaluation of this novel antiplasmodial combination therapy., This work was funded by the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID: 10.13039/100009945). M.P. is a recipient of a “Concurso de Estímulo ao Emprego Científico” Principal Investigator award of Fundação para a Ciência e Tecnologia, Portugal (FCT), with ref. N. CEECIND/03539/2017. D.F. is funded by FCT project CRCNA/BRB/0281/2019. F.A. is recipient of a PhD fellowship PD/BD/128371/2017, funded by FCT.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results