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Your search keyword '"Brisco, Meredith A."' showing total 170 results
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170 results on '"Brisco, Meredith A."'

17. Serum dilutions as a predictive biomarker for peri-operative desensitization: An exploratory approach to transplanting sensitized heart candidates

Author

Timofeeva, Olga A., primary, Alvarez, Rene, additional, Pelberg, Justin, additional, Yoon, Edward, additional, Alsammak, Mohamed, additional, Geier, Steve S., additional, Ruggia-Check, Christina, additional, Hassler, Jared, additional, Hoosain, Jamael, additional, Brisco, Meredith A., additional, Afari-Armah, Nana, additional, Rakita, Val, additional, Brann, Stacey, additional, Keshavamurthy, Suresh, additional, Gomez-Abraham, Jesus, additional, Minakata, Kenji, additional, Toyoda, Yoshiya, additional, and Hamad, Eman, additional

Published
2020
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19. Substantial discrepancy between fluid and weight loss during acute decompensated heart failure treatment: Important lessons for research and clinical care

Author

Testani, Jeffrey M., Brisco, Meredith A., Kociol, Robb D., Jacoby, Daniel, Bellumkonda, Lavanya, Parikh, Chirag R., Coca, Steven G., and Wilson Tang, W. H.

Subjects
Male, Risk Assessment, Severity of Illness Index, Article, Drug Administration Schedule, Statistics, Nonparametric, Cohort Studies, Sex Factors, Double-Blind Method, Weight Loss, Humans, Diuretics, Infusions, Intravenous, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Heart Failure, Dose-Response Relationship, Drug, Age Factors, Middle Aged, Body Fluids, Survival Rate, Treatment Outcome, Acute Disease, Female, Follow-Up Studies
Abstract

Net fluid and weight loss are used ubiquitously to monitor diuretic response in acute decompensated heart failure research and patient care. However, the performance of these metrics has never been evaluated critically. The weight and volume of aqueous fluids such as urine should be correlated nearly perfectly and with very good agreement. As a result, significant discrepancy between fluid and weight loss during the treatment of acute decompensated heart failure would indicate measurement error in 1 or both of the parameters.The correlation and agreement (Bland-Altman method) between diuretic-induced fluid and weight loss were examined in 3 acute decompensated heart failure trials and cohorts: (1) Diuretic Optimization Strategies Evaluation (DOSE) (n = 254); (2) Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) (n = 348); and (3) Penn (n = 486).The correlation between fluid and weight loss was modest (DOSE r = 0.55; ESCAPE r = 0.48; Penn r = 0.51; P.001 for all), and the 95% limits of agreement were wide (DOSE -7.9 to 6.4 kg-L; ESCAPE -11.6 to 7.5 kg-L; Penn -14.5 to 11.3 kg-L). The median relative disagreement ranged from ±47.0% to 63.5%. A bias toward greater fluid than weight loss was found across populations (-0.74 to -2.1 kg-L, P ≤ .002). A consistent pattern of baseline characteristics or in-hospital treatment parameters that could identify patients at risk of discordant fluid and weight loss was not found.Considerable discrepancy between fluid balance and weight loss is common in patients treated for acute decompensated heart failure. Awareness of the limitations inherent to these commonly used metrics and efforts to develop more reliable measures of diuresis are critical for both patient care and research in acute decompensated heart failure.

Published
2015

21. Hypochloremia and Diuretic Resistance in Heart Failure

Author

Hanberg, Jennifer S., primary, Rao, Veena, additional, ter Maaten, Jozine M., additional, Laur, Olga, additional, Brisco, Meredith A., additional, Perry Wilson, F., additional, Grodin, Justin L., additional, Assefa, Mahlet, additional, Samuel Broughton, J., additional, Planavsky, Noah J., additional, Ahmad, Tariq, additional, Bellumkonda, Lavanya, additional, Wilson Tang, W. H., additional, Parikh, Chirag R., additional, and Testani, Jeffrey M., additional

Published
2016
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26. Influence of Titration of Neurohormonal Antagonists and Blood Pressure Reduction on Renal Function and Decongestion in Decompensated Heart Failure

Author

Kula, Alexander J., primary, Hanberg, Jennifer S., additional, Wilson, F. Perry, additional, Brisco, Meredith A., additional, Bellumkonda, Lavanya, additional, Jacoby, Daniel, additional, Coca, Steven G., additional, Parikh, Chirag R., additional, Tang, W.H. Wilson, additional, and Testani, Jeffrey M., additional

Published
2016
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38. Loop Diuretic Efficiency

Author

Testani, Jeffrey M., primary, Brisco, Meredith A., additional, Turner, Jeffrey M., additional, Spatz, Erica S., additional, Bellumkonda, Lavanya, additional, Parikh, Chirag R., additional, and Tang, W.H. Wilson, additional

Published
2014
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39. Sexual Function After Left Ventricular Assist Device

Author

Eckman, Peter M., primary, Dhungel, Vinayak, additional, Mandras, Stacy, additional, Brisco, Meredith A., additional, Emani, Sitaramesh, additional, Duval, Sue, additional, Lindenfeld, JoAnn, additional, Sulemanjee, Nasir, additional, Sokos, George G., additional, and Feldman, Jamie, additional

Published
2013
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43. Women With Cardiogenic Shock Derive Greater Benefit From Early Mechanical Circulatory Support: An Update From the cVAD Registry.

Author

Joseph, Susan M., Brisco, Meredith A., Colvin, Monica, Grady, Kathleen L., Walsh, Mary Norine, and Cook, Jennifer L.

Subjects
*CARDIOGENIC shock, *HEART assist devices, *MYOCARDIAL infarction treatment, *CARDIAC surgery, *HEALTH outcome assessment, *MYOCARDIAL infarction complications, *CARDIOVASCULAR system, *COMPARATIVE studies, *HEMODYNAMICS, *RESEARCH methodology, *MEDICAL care, *MEDICAL cooperation, *RESEARCH, *SURVIVAL, *WOMEN'S health, *EVALUATION research, *TREATMENT effectiveness, *ACQUISITION of data, *RETROSPECTIVE studies, *THERAPEUTICS, MYOCARDIAL infarction-related mortality
Abstract

Objectives: The aim of this analysis was to assess survival differences between men and women supported with Impella 2.5 (Abiomed Inc., Danvers) in the setting of acute myocardial infarction (AMI) complicated by cardiogenic shock (CS).Background: Data on sex differences in outcomes of CS with mechanical circulatory support are sparse.Methods: Patients enrolled in the cVAD Registry who underwent percutaneous coronary intervention (PCI) and Impella 2.5 support for CS complicating an AMI were included. Differences between men and women were examined.Results: In total, 180 patients were analyzed. Women (n = 49, 27.2%) were older (71.0 ± 12.8 years vs 63.8 ± 13.0, P = 0.001), smaller (BSA 1.82 ± 0.22 vs 2.04 ± 0.24 m(2) , P < 0.001), and had a higher STS mortality risk score than men (27.9 ± 17.0 vs. 20.8 ± 16.8 P = 0.01). There was no difference in survival to discharge (P = 0.3). Patients receiving the Impella 2.5 pre-PCI had significantly lower inpatient mortality than those who received support post-PCI (P = 0.003). However, the magnitude of the survival benefit was significantly greater in women who received the Impella pre-PCI as compared to men. Overall, 68.8% of women survived with pre-PCI Impella 2.5 versus 24.2% post-PCI (P = 0.005) whereas 54.2% of men survived with pre-PCI Impella 2.5 versus 40.3% post-PCI (P = 0.1, p-interaction = 0.07). No differences in timing to intervention were found between men and women.Conclusions: Early initiation of hemodynamic support prior to PCI with Impella 2.5, in the setting of AMI complicated by CS, was associated with a greater survival benefit to hospital discharge in women compared to men, despite a higher predicted risk of mortality and a greater revascularization failure rate for women. (J Interven Cardiol 2016;29:248-256). [ABSTRACT FROM AUTHOR]

Published
2016
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