116 results on '"Brinkman N"'
Search Results
2. The InSight HP$^3$ Penetrator (Mole) on Mars: Soil Properties Derived From the Penetration Attempts and Related Activities
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Spohn, T., Hudson, T. L., Marteau, E., Golombek, M., Grott, M., Wippermann, T., Ali, K. S., Schmelzbach, C., Kedar, S., Hurst, K., Trebi-Ollennu, A., Ansan, V., Garvin, J., Knollenberg, J., Mueller, N., Piqeux, S., Lichtenheldt, R., Krause, C., Fantinati, C., Brinkman, N., Sollberger, D., Delage, P., Vrettos, C., Reershemius, S., Wisniewski, L., Grygorczuk, J., Robertsson, J., Edme, P., Andersson, F., Kroemer, O., Lognonne, P., Giardini, D., Smrekar, S. E., and Banerdt, W. B.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
The NASA InSight Lander on Mars includes the Heat Flow and Physical Properties Package HP$^3$ to measure the surface heat flow of the planet. The package uses temperature sensors that would have been brought to the target depth of 3--5 m by a small penetrator, nicknamed the mole. The mole requiring friction on its hull to balance remaining recoil from its hammer mechanism did not penetrate to the targeted depth. Instead, by precessing about a point midway along its hull, it carved a 7 cm deep and 5-6 cm wide pit and reached a depth of initially 31 cm. The root cause of the failure - as was determined through an extensive, almost two years long campaign - was a lack of friction in an unexpectedly thick cohesive duricrust. During the campaign -- described in detail in this paper -- the mole penetrated further aided by friction applied using the scoop at the end of the robotic Instrument Deployment Arm and by direct support by the latter. The mole finally reached a depth of 40 cm, bringing the mole body 1--2 cm below the surface. The penetration record of the mole and its thermal sensors were used to measure thermal and mechanical soil parameters such as the thermal conductivity and the penetration resistance of the duricrust and its cohesion. The hammerings of the mole were recorded by the seismometer SEIS and the signals could be used to derive a P-wave velocity and a S-wave velocity and elastic moduli representative of the topmost tens of cm of the regolith. The combined data were used to derive a model of the regolith that has an about 20 cm thick duricrust underneath a 1 cm thick unconsolidated layer of sand mixed with dust and above another 10 cm of unconsolidated sand. Underneath the latter, a layer more resistant to penetration and possibly consisting of debris from a small impact crater is inferred., Comment: 78 pages 22 figures, , submitted to Space Science Reviews
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- 2021
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3. Statistical groupings of mental and social health measurements correlate with musculoskeletal capability – A cross sectional study
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Broekman, M.M., Brinkman, N., Davids, F.A., Padilla, J.C., Doornberg, J.N., Ring, D., and Jayakumar, P.
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- 2024
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4. Exploring the near-surface at the lunar South Pole with geophysical tools
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Schmelzbach, C., Stähler, S., Schmerr, N. C., Knapmeyer, M., Sollberger, D., Edme, P., Khan, A., Brinkman, N., Ferraioli, L., Robertsson, J. O. A., and Giardini, D.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
Geophysical imaging of the lunar near-surface structure will be key for in situ resource utilization, identification of hazards for crews and infrastructure, and answering science questions on the formation and interior of the Moon. The goal of this white paper is to highlight the value of ground-based geophysical experiments by a crew and to outline a series of experiments to address key science questions. Specifically, we propose for the Artemis III crewed mission multidisciplinary investigations using geophysical methods such as seismic, seismological, ground penetrating radar, and electromagnetic techniques. We identified a series of prime near-surface targets for such geophysical investigations: (1) establishing a lunar fault monitoring observatory across a lobate scarp to study recent lunar seismicity, (2) determining the physical properties of the regolith at the landing site, (3) investigating the structure and in-situ properties of permanently shadowed regions in the context of the search for water ice and other cold-trapped volatiles, and (4) imaging the interior structure of the South-Pole Aitken basin. Beyond Artemis III, the Moon will serve as a comprehensive testbed for extra-terrestrial geophysics. Hence, lessons learned from human geophysical exploration of the Moon will be key for the exploration of the moons of Mars and near-Earth object(s), and prepare us for the human exploration of space beyond the Moon., Comment: 2 pages, 1 figure, 27 references
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- 2020
5. Measuring Fundamental and Higher Mode Surface Wave Dispersion on Mars From Seismic Waveforms
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Xu, Haotian, Beghein, C, Panning, MP, Drilleau, M, Lognonné, P, van Driel, M, Ceylan, S, Böse, M, Brinkman, N, Clinton, J, Euchner, F, Giardini, D, Horleston, A, Kawamura, T, Kenda, B, Murdoch, N, and Stähler, S
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- 2021
6. Seismic sources of InSight marsquakes and seismotectonic context of Elysium Planitia, Mars
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Jacob, A., Plasman, M., Perrin, C., Fuji, N., Lognonné, P., Xu, Z., Drilleau, M., Brinkman, N., Stähler, S., Sainton, G., Lucas, A., Giardini, D., Kawamura, T., Clinton, J., and Banerdt, W.B.
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- 2022
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7. The InSight HP3 Penetrator (Mole) on Mars: Soil Properties Derived from the Penetration Attempts and Related Activities
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Spohn, T., Hudson, T. L., Marteau, E., Golombek, M., Grott, M., Wippermann, T., Ali, K. S., Schmelzbach, C., Kedar, S., Hurst, K., Trebi-Ollennu, A., Ansan, V., Garvin, J., Knollenberg, J., Müller, N., Piqueux, S., Lichtenheldt, R., Krause, C., Fantinati, C., Brinkman, N., Sollberger, D., Delage, P., Vrettos, C., Reershemius, S., Wisniewski, L., Grygorczuk, J., Robertsson, J., Edme, P., Andersson, F., Krömer, O., Lognonné, P., Giardini, D., Smrekar, S. E., and Banerdt, W. B.
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- 2022
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8. Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data
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Lognonné, P., Banerdt, W. B., Pike, W. T., Giardini, D., Christensen, U., Garcia, R. F., Kawamura, T., Kedar, S., Knapmeyer-Endrun, B., Margerin, L., Nimmo, F., Panning, M., Tauzin, B., Scholz, J.-R., Antonangeli, D., Barkaoui, S., Beucler, E., Bissig, F., Brinkman, N., Calvet, M., Ceylan, S., Charalambous, C., Davis, P., van Driel, M., Drilleau, M., Fayon, L., Joshi, R., Kenda, B., Khan, A., Knapmeyer, M., Lekic, V., McClean, J., Mimoun, D., Murdoch, N., Pan, L., Perrin, C., Pinot, B., Pou, L., Menina, S., Rodriguez, S., Schmelzbach, C., Schmerr, N., Sollberger, D., Spiga, A., Stähler, S., Stott, A., Stutzmann, E., Tharimena, S., Widmer-Schnidrig, R., Andersson, F., Ansan, V., Beghein, C., Böse, M., Bozdag, E., Clinton, J., Daubar, I., Delage, P., Fuji, N., Golombek, M., Grott, M., Horleston, A., Hurst, K., Irving, J., Jacob, A., Knollenberg, J., Krasner, S., Krause, C., Lorenz, R., Michaut, C., Myhill, R., Nissen-Meyer, T., ten Pierick, J., Plesa, A.-C., Quantin-Nataf, C., Robertsson, J., Rochas, L., Schimmel, M., Smrekar, S., Spohn, T., Teanby, N., Tromp, J., Vallade, J., Verdier, N., Vrettos, C., Weber, R., Banfield, D., Barrett, E., Bierwirth, M., Calcutt, S., Compaire, N., Johnson, C.L., Mance, D., Euchner, F., Kerjean, L., Mainsant, G., Mocquet, A., Rodriguez Manfredi, J. A, Pont, G., Laudet, P., Nebut, T., de Raucourt, S., Robert, O., Russell, C. T., Sylvestre-Baron, A., Tillier, S., Warren, T., Wieczorek, M., Yana, C., and Zweifel, P.
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- 2020
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9. Applications of Time‐Frequency Domain Polarization Filtering to InSight Seismic Data
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Brinkman, N., primary, Sollberger, D., additional, Schmelzbach, C., additional, Stähler, S. C., additional, and Robertsson, J., additional
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- 2023
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10. Planetary Seismology: Nearly 3 years on Mars, and a return to the Moon
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Yana, Charles, Weber, Renee, Walsh, William, Standley, Ian, de Raucourt, Sebastien, Pont, Gabriel, Pike, W. Tom, Nunn, Ceri, Lognonné, Philippe, Kawamura, Taichi, Garcia, Raphael, Elliott, John, Cutler, James, Calcutt, Simon, Bugby, David, Bowles, Neil, Kedar, Sharon, Tharimena, S, Tauzin, B, Stutzmann, E, Schimmel, M, Schmelzbach, C, Nunn, C, Murdoch, N, Lekic, V, Brinkman, N, Kenda, B, Fayon, L, Spiga, A, Stott, A. E, Stähler, S, Orhand-Mainsant, G, Knapmeyer, M, Khan, A, Horleston, A, van Driel, M, Charalambous, C, Ceylan, S, Böse, M, Drilleau, M, Hurst, K, Weber, R, Teanby, N, Schmerr, N, Mimoun, D, Margerin, L, Knapmeyer-Endrun, B, Kedar, S, Kawamura, T, Irving, J, Garcia, R, Clinton, J, Bozdag, E, Lorenz, R, Giardini, D, Pike, W.T, Lognonné, P, Banerdt, W.B, and Panning, Mark
- Published
- 2021
11. Planetary Seismology: Nearly 3 years on Mars, and a return to the Moon
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Panning, Mark, Banerdt, W.B, Lognonné, P, Pike, W.T, Giardini, D, Lorenz, R, Bozdag, E, Clinton, J, Garcia, R, Irving, J, Kawamura, T, Kedar, S, Knapmeyer-Endrun, B, Margerin, L, Mimoun, D, Schmerr, N, Teanby, N, Weber, R, Hurst, K, Drilleau, M, Böse, M, Ceylan, S, Charalambous, C, van Driel, M, Horleston, A, Khan, A, Knapmeyer, M, Orhand-Mainsant, G, Stähler, S, Stott, A. E, Spiga, A, Fayon, L, Kenda, B, Brinkman, N, Lekic, V, Murdoch, N, Nunn, C, Schmelzbach, C, Schimmel, M, Stutzmann, E, Tauzin, B, Tharimena, S, Kedar, Sharon, Bowles, Neil, Bugby, David, Calcutt, Simon, Cutler, James, Elliott, John, Garcia, Raphael, Kawamura, Taichi, Lognonné, Philippe, Nunn, Ceri, Pike, W. Tom, Pont, Gabriel, de Raucourt, Sebastien, Standley, Ian, Walsh, William, Weber, Renee, and Yana, Charles
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- 2021
12. Results From Insight’s First Full Martian Year
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Wieczorek, M, Weber, R, Warner, N, Tromp, J, Teanby, N, Stanley, S, Stahler, S, Spohn, T, Spiga, A, Siegler, M, Schmerr, N, Rodriguez-Manfredi, P.J.A, Plesa, A.-C, Pike, W.T, Nimmo, Francis, Newman, C, Nagihara, S, Müller, N, Morgan, P, Mittelholz, A, Mimoun, D, Michaut, C, McLennan, S, Margerin, L, Maki, J, Lorenz, R, Lognonné, P, Lemmon, M, Knapmeyer-Endrun, B, King, S, Khan, A, Kedar, S, Kawamura, Taichi, Kargl, G, Joshi, R, Johnson, C, Irving, J, Hudson, T, Grygorczuk, J, Grott, M, Grant, J, Golombek, M, Giardini, D, Garvin, J, Garcia, R, Folkner, W, Fillingim, M, Dehant, V, Daubar, I, Collins, G, Clinton, J, Christensen, U, Chi, P, Ceylan, S, Brinkman, N, Bozdag, Ebru, Bowles, Neil, Bissig, F, Beucler, E, Beghein, C, Banfield, D, Asmar, S, Antonangeli, D, Smrekar, S, Banerdt, W. B, and Panning, M.P
- Published
- 2021
13. Results From Insight’s First Full Martian Year
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Panning, M.P, Banerdt, W. B, Smrekar, S, Antonangeli, D, Asmar, S, Banfield, D, Beghein, C, Beucler, E, Bissig, F, Bowles, Neil, Bozdag, Ebru, Brinkman, N, Ceylan, S, Chi, P, Christensen, U, Clinton, J, Collins, G, Daubar, I, Dehant, V, Fillingim, M, Folkner, W, Garcia, R, Garvin, J, Giardini, D, Golombek, M, Grant, J, Grott, M, Grygorczuk, J, Hudson, T, Irving, J, Johnson, C, Joshi, R, Kargl, G, Kawamura, Taichi, Kedar, S, Khan, A, King, S, Knapmeyer-Endrun, B, Lemmon, M, Lognonné, P, Lorenz, R, Maki, J, Margerin, L, McLennan, S, Michaut, C, Mimoun, D, Mittelholz, A, Morgan, P, Müller, N, Nagihara, S, Newman, C, Nimmo, Francis, Pike, W.T, Plesa, A.-C, Rodriguez-Manfredi, P.J.A, Schmerr, N, Siegler, M, Spiga, A, Spohn, T, Stahler, S, Stanley, S, Teanby, N, Tromp, J, Warner, N, Weber, R, and Wieczorek, M
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- 2021
14. Perenbomen in de Waddenzee
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Dickson, J., Franken, O., Watson, M.S., Mönnich, B., Holthuijsen, S.J., Eriksson, B.K., Govers, L.L., Heide, T. van der, Bouma, T.J., Smeele, Q., Brinkman, N., Dickson, J., Franken, O., Watson, M.S., Mönnich, B., Holthuijsen, S.J., Eriksson, B.K., Govers, L.L., Heide, T. van der, Bouma, T.J., Smeele, Q., and Brinkman, N.
- Abstract
Als experiment construeerde NIOZ-promovendus Jon Dickson met behulp van dode perenbomen een aantal kunstmatige riffen. Deze zijn op meerdere locaties in de Waddenzee geplaatst. Al na enkele maanden bleken deze riffen onderdak te bieden aan allerlei soorten dieren. In vergelijking met controlelocaties werden er meer vissoorten en grotere aantallen vissen waargenomen. Mogelijk kunnen dergelijke riffen in de toekomst een belangrijke bijdrage leveren aan de onderwaternatuur van de Waddenzee.
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- 2023
15. Comparison of proactive and conventional treatment of anastomotic leakage in rectal cancer surgery:a multicentre retrospective cohort series
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Talboom, K., Greijdanus, N. G., Brinkman, N., Blok, R. D., Roodbeen, S. X., Ponsioen, C. Y., Tanis, P. J., Bemelman, W. A., Cunningham, C., de Lacy, F. B., Hompes, Roel, Talboom, K., Greijdanus, N. G., Brinkman, N., Blok, R. D., Roodbeen, S. X., Ponsioen, C. Y., Tanis, P. J., Bemelman, W. A., Cunningham, C., de Lacy, F. B., and Hompes, Roel
- Abstract
Purpose: Comparative studies on efficacy of treatment strategies for anastomotic leakage (AL) after low anterior resection (LAR) are almost non-existent. This study aimed to compare different proactive and conservative treatment approaches for AL after LAR. Methods: This retrospective cohort study included all patients with AL after LAR in three university hospitals. Different treatment approaches were compared, including a pairwise comparison of conventional treatment and endoscopic vacuum-assisted surgical closure (EVASC). Primary outcomes were healed and functional anastomosis rates at end of follow-up. Results: Overall, 103 patients were included, of which 59 underwent conventional treatment and 23 EVASC. Median number of reinterventions was 1 after conventional treatment, compared to 7 after EVASC (p < 0.01). Median follow-up was 39 and 25 months, respectively. Healed anastomosis rate was 61% after conventional treatment, compared to 78% after EVASC (p = 0.139). Functional anastomosis rate was higher after EVASC, compared to conventional treatment (78% vs. 54%, p = 0.045). Early initiation of EVASC in the first week after primary surgery resulted in better functional anastomosis rate compared to later initiation (100% vs. 55%, p = 0.008). Conclusion: Proactive treatment of AL consisting of EVASC resulted in improved healed and functional anastomosis rates for AL after LAR for rectal cancer, compared to conventional treatment. If EVASC was initiated within the first week after index surgery, a 100% functional anastomosis rate was achievable.
- Published
- 2023
16. The InSight HP3 Penetrator (Mole) on Mars: Soil Properties Derived from the Penetration Attempts and Related Activities.
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Spohn, T., Hudson, T. L., Marteau, E., Golombek, M., Grott, M., Wippermann, T., Ali, K. S., Schmelzbach, C., Kedar, S., Hurst, K., Trebi-Ollennu, A., Ansan, V., Garvin, J., Knollenberg, J., Müller, N., Piqueux, S., Lichtenheldt, R., Krause, C., Fantinati, C., and Brinkman, N.
- Abstract
The NASA InSight Lander on Mars includes the Heat Flow and Physical Properties Package HP
3 to measure the surface heat flow of the planet. The package uses temperature sensors that would have been brought to the target depth of 3–5 m by a small penetrator, nicknamed the mole. The mole requiring friction on its hull to balance remaining recoil from its hammer mechanism did not penetrate to the targeted depth. Instead, by precessing about a point midway along its hull, it carved a 7 cm deep and 5–6 cm wide pit and reached a depth of initially 31 cm. The root cause of the failure – as was determined through an extensive, almost two years long campaign – was a lack of friction in an unexpectedly thick cohesive duricrust. During the campaign – described in detail in this paper – the mole penetrated further aided by friction applied using the scoop at the end of the robotic Instrument Deployment Arm and by direct support by the latter. The mole tip finally reached a depth of about 37 cm, bringing the mole back-end 1–2 cm below the surface. It reversed its downward motion twice during attempts to provide friction through pressure on the regolith instead of directly with the scoop to the mole hull. The penetration record of the mole was used to infer mechanical soil parameters such as the penetration resistance of the duricrust of 0.3–0.7 MPa and a penetration resistance of a deeper layer (> 30 cm depth) of 4.9 ± 0.4 MPa . Using the mole’s thermal sensors, thermal conductivity and diffusivity were measured. Applying cone penetration theory, the resistance of the duricrust was used to estimate a cohesion of the latter of 2–15 kPa depending on the internal friction angle of the duricrust. Pushing the scoop with its blade into the surface and chopping off a piece of duricrust provided another estimate of the cohesion of 5.8 kPa. The hammerings of the mole were recorded by the seismometer SEIS and the signals were used to derive P-wave and S-wave velocities representative of the topmost tens of cm of the regolith. Together with the density provided by a thermal conductivity and diffusivity measurement using the mole’s thermal sensors, the elastic moduli were calculated from the seismic velocities. Using empirical correlations from terrestrial soil studies between the shear modulus and cohesion, the previous cohesion estimates were found to be consistent with the elastic moduli. The combined data were used to derive a model of the regolith that has an about 20 cm thick duricrust underneath a 1 cm thick unconsolidated layer of sand mixed with dust and above another 10 cm of unconsolidated sand. Underneath the latter, a layer more resistant to penetration and possibly containing debris from a small impact crater is inferred. The thermal conductivity increases from 14 mW/m K to 34 mW/m K through the 1 cm sand/dust layer, keeps the latter value in the duricrust and the sand layer underneath and then increases to 64 mW/m K in the sand/gravel layer below. [ABSTRACT FROM AUTHOR]- Published
- 2022
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17. Characterization of the relative importance of human- and infrastructure-associated bacteria in grey water: a case study
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Keely, S. P., Brinkman, N. E., Zimmerman, B. D., Wendell, D., Ekeren, K. M., De Long, S. K., Sharvelle, S., and Garland, J. L.
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- 2015
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18. Cell-free oxidized hemoglobin drives reactive oxygen species production and pro-inflammation in an immature primary rat mixed glial cell culture
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Agyemang AA, Kvist SV, Brinkman N, Gentinetta T, Illa-Armengol M, Ortenlöf N, Holmqvist B, Ley D, and Gram M
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Redox ,Intraventricular hemorrhage ,Haptoglobin ,Mixed glial cells ,Hemoglobin metabolites ,Hemorrhagic cerebrospinal fluid - Abstract
BACKGROUND: Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from hemorrhagic cerebrospinal fluid (CSF), in the cerebrum and cerebellum. In a recent study, using a preterm rabbit pup model of IVH, intraventricularly administered haptoglobin (Hp), a cell-free Hb scavenger, partially reversed the damaging effects observed following IVH. Together, this suggests that cell-free Hb is central in the pathophysiology of the injury to the immature brain following GM-IVH. An increased understanding of the causal pathways and metabolites involved in eliciting the damaging response following hemorrhage is essential for the continued development and implementation of neuroprotective treatments of GM-IVH in preterm infant. METHODS: We exposed immature primary rat mixed glial cells to hemorrhagic CSF obtained from preterm human infants with IVH (containing a mixture of Hb-metabolites) or to a range of pure Hb-metabolites, incl. oxidized Hb (mainly metHb with iron in Fe(3+)), oxyHb (mainly Fe(2+)), or low equivalents of heme, with or without co-administration with human Hp (a mixture of isotype 2-2/2-1). Following exposure, cellular response, reactive oxygen species (ROS) generation, secretion and expression of pro-inflammatory cytokines and oxidative markers were evaluated. RESULTS: Exposure of the glial cells to hemorrhagic CSF as well as oxidized Hb, but not oxyHb, resulted in a significantly increased rate of ROS production that positively correlated with the rate of production of pro-inflammatory and oxidative markers. Congruently, exposure to oxidized Hb caused a disintegration of the polygonal cytoskeletal structure of the glial cells in addition to upregulation of F-actin proteins in microglial cells. Co-administration of Hp partially reversed the damaging response of hemorrhagic CSF and oxidized Hb. CONCLUSION: Exposure of mixed glial cells to oxidized Hb initiates a pro-inflammatory and oxidative response with cytoskeletal disintegration. Early administration of Hp, aiming to minimize the spontaneous autoxidation of cell-free oxyHb and liberation of heme, may provide a therapeutic benefit in preterm infant with GM-IVH.
- Published
- 2021
19. Promoting HIV indicator condition-guided testing in hospital settings (PROTEST 2.0): study protocol for a multicentre interventional study
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Bogers, Saskia J., Schim van der Loeff, Maarten F., Davidovich, Udi, Boyd, Anders, van der Valk, Marc, Brinkman, Kees, de Bree, Godelieve J., Reiss, Peter, van Bergen, Jan E. A. M., Geerlings, Suzanne E., van Bergen, J. E. A. M., Brokx, P., Deug, F., Heidenrijk, M., Prins, M., Reiss, P., van der Valk, M., de Bree, G. J., Geerlings, S. E., Hoornenborg, E., Achterbergh, R. C. A., Ananworanich, J., van de Beek, D., Brinkman, N., de Bruin, M., Bruisten, S., Coyer, L., Dijkstra, M., Geijtenbeek, T. B. H., Godfried, M. H., Goorhuis, A., Hankins, C. A., Hogewoning, A., Hovius, J. W., de Jong, K., Kootstra, N. A., Lauw, F., van der Meer, J. T., Mulder, B. J., Nellen, F. J., Peters, E., van der Poll, T., van Rooijen, M. S., Sonder, G. J., de Vries, H. J., van Vugt, M., Wiersinga, W. J., Wit, F. W., Zantkuijl, P., Graduate School, Vascular Medicine, AII - Infectious diseases, Infectious diseases, APH - Aging & Later Life, APH - Global Health, Global Health, General practice, APH - Methodology, APH - Quality of Care, Medical Microbiology and Infection Prevention, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Experimental Immunology, Center of Experimental and Molecular Medicine, Dermatology, APH - Digital Health, APH - Personalized Medicine, Sociale Psychologie (Psychologie, FMG), Psychology Other Research (FMG), Stichting Aidsfonds, Virology, Medical Microbiology & Infectious Diseases, and Internal Medicine
- Subjects
medicine.medical_specialty ,Pediatrics ,Tuberculosis ,Multifaceted intervention ,HIV Positivity ,HIV Transmission Elimination AMsterdam (H-TEAM) Consortium ,HIV Infections ,Infectious and parasitic diseases ,RC109-216 ,Indicator condition ,Healthcare quality improvement ,Microbiology ,03 medical and health sciences ,Study Protocol ,0302 clinical medicine ,Medical microbiology ,SDG 3 - Good Health and Well-being ,1108 Medical Microbiology ,Intervention (counseling) ,medicine ,Clinical endpoint ,Prevalence ,Humans ,Mass Screening ,030212 general & internal medicine ,Netherlands ,030505 public health ,business.industry ,Patient Selection ,virus diseases ,1103 Clinical Sciences ,Hepatitis B ,Vulvar cancer ,medicine.disease ,Hospitals ,HIV testing ,Infectious Diseases ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Implementation ,Tropical medicine ,0305 other medical science ,business ,0605 Microbiology - Abstract
Background Late presentation remains a key barrier towards controlling the HIV epidemic. Indicator conditions (ICs) are those that are AIDS-defining, associated with a prevalence of undiagnosed HIV > 0.1%, or whose clinical management would be impeded if an HIV infection were undiagnosed. IC-guided HIV testing is an effective strategy in identifying undiagnosed HIV, but opportunities for earlier HIV diagnosis through IC-guided testing are being missed. We present a protocol for an interventional study to improve awareness of IC-guided testing and increase HIV testing in patients presenting with ICs in a hospital setting. Methods We designed a multicentre interventional study to be implemented at five hospitals in the region of Amsterdam, the Netherlands. Seven ICs were selected for which HIV test ratios (proportion of patients with an IC tested for HIV) will be measured: tuberculosis, cervical/vulvar cancer or high-grade cervical/vulvar dysplasia, malignant lymphoma, hepatitis B and C, and peripheral neuropathy. Prior to the intervention, a baseline assessment of HIV test ratios across ICs will be performed in eligible patients (IC diagnosed January 2015 through May 2020, ≥18 years, not known HIV positive) and an assessment of barriers and facilitators for HIV testing amongst relevant specialties will be conducted using qualitative (interviews) and quantitative methods (questionnaires). The intervention phase will consist of an educational intervention, including presentation of baseline results as competitive graphical audit and feedback combined with discussion on implementation and opportunities for improvement. The effect of the intervention will be assessed by comparing HIV test ratios of the pre-intervention and post-intervention periods. The primary endpoint is the HIV test ratio within ±3 months of IC diagnosis. Secondary endpoints are the HIV test ratio within ±6 months of diagnosis, ratio ever tested for HIV, HIV positivity percentage, proportion of late presenters and proportion with known HIV status prior to initiating treatment for their IC. Discussion This protocol presents a strategy aimed at increasing awareness of the benefits of IC-guided testing and increasing HIV testing in patients presenting with ICs in hospital settings to identify undiagnosed HIV in Amsterdam, the Netherlands. Trial registration Dutch trial registry: NL7521. Registered 14 February 2019.
- Published
- 2021
20. Thickness and structure of the Martian crust from InSight seismic data
- Author
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California Institute of Technology, Swiss National Science Foundation, European Commission, NASA Astrobiology Institute (US), Canadian Space Agency, European Space Agency, Knapmeyer‐Endrun, Brigitte, Panning, M.P., Bissig, F., Joshi, R., Khan, A., Kim, D., Lekic, Vedran, Tauzin, B., Tharimena, S., Plasman, M., Compaire, N., Garcia, R. F., Margerin, L., Schimmel, Martin, Stutzmann, E., Schmerr, N., Bozdag, E., Plesa, A. C., Wieczorek, M. A., Broquet, A., Antonangeli, D., McLennan, Scott M., Samuel, H., Michaut, C., Pan, L., Smrekar, S. E., Johnson, C.L., Brinkman, N., Mittelholz, A., Rivoldini, A., Davis, P. M., Lognonné, P., Pinot, B, Scholz, J. R., Stahler, Simon, Knapmeyer, M., van Driel, M., Giardini, Domenico, Banerdt, W. B., California Institute of Technology, Swiss National Science Foundation, European Commission, NASA Astrobiology Institute (US), Canadian Space Agency, European Space Agency, Knapmeyer‐Endrun, Brigitte, Panning, M.P., Bissig, F., Joshi, R., Khan, A., Kim, D., Lekic, Vedran, Tauzin, B., Tharimena, S., Plasman, M., Compaire, N., Garcia, R. F., Margerin, L., Schimmel, Martin, Stutzmann, E., Schmerr, N., Bozdag, E., Plesa, A. C., Wieczorek, M. A., Broquet, A., Antonangeli, D., McLennan, Scott M., Samuel, H., Michaut, C., Pan, L., Smrekar, S. E., Johnson, C.L., Brinkman, N., Mittelholz, A., Rivoldini, A., Davis, P. M., Lognonné, P., Pinot, B, Scholz, J. R., Stahler, Simon, Knapmeyer, M., van Driel, M., Giardini, Domenico, and Banerdt, W. B.
- Abstract
A planet's crust bears witness to the history of planetary formation and evolution, but for Mars, no absolute measurement of crustal thickness has been available. Here, we determine the structure of the crust beneath the InSight landing site on Mars using both marsquake recordings and the ambient wavefield. By analyzing seismic phases that are reflected and converted at subsurface interfaces, we find that the observations are consistent with models with at least two and possibly three interfaces. If the second interface is the boundary of the crust, the thickness is 20 +/- 5 kilometers, whereas if the third interface is the boundary, the thickness is 39 +/- 8 kilometers. Global maps of gravity and topography allow extrapolation of this point measurement to the whole planet, showing that the average thickness of the martian crust lies between 24 and 72 kilometers. Independent bulk composition and geodynamic constraints show that the thicker model is consistent with the abundances of crustal heat-producing elements observed for the shallow surface, whereas the thinner model requires greater concentration at depth.
- Published
- 2021
21. Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data
- Author
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Lognonné, P.; Banerdt, W.B.; Pike, W.T.; Giardini, D.; Christensen, U.; Garcia, R.F.; Kawamura, T.; Kedar, S.; Knapmeyer-Endrun, B.; Margerin, L.; Nimmo, F.; Panning, M.; Tauzin, B.; Scholz, J.R.; Antonangeli, D.; Barkaoui, S.; Beucler, E.; Bissig, F.; Brinkman, N.; Calvet, M.; Ceylan, S.; Charalambous, C.; Davis, P.; van Driel, M.; Drilleau, M.; Fayon, L.; Joshi, R.; Kenda, B.; Khan, A.; Knapmeyer, M.; Lekic, V.; McClean, J.; Mimoun, D.; Murdoch, N.; Pan, L.; Perrin, C.; Pinot, B.; Pou, L.; Menina, S.; Rodriguez, S.; Schmelzbach, C.; Schmerr, N.; Sollberger, D.; Spiga, A.; Stähler, S.; Stott, A.; Stutzmann, E.; Tharimena, S.; Widmer-Schnidrig, R.; Schimmel, M.; Rodriguez Manfredi, J.A. and Lognonné, P.; Banerdt, W.B.; Pike, W.T.; Giardini, D.; Christensen, U.; Garcia, R.F.; Kawamura, T.; Kedar, S.; Knapmeyer-Endrun, B.; Margerin, L.; Nimmo, F.; Panning, M.; Tauzin, B.; Scholz, J.R.; Antonangeli, D.; Barkaoui, S.; Beucler, E.; Bissig, F.; Brinkman, N.; Calvet, M.; Ceylan, S.; Charalambous, C.; Davis, P.; van Driel, M.; Drilleau, M.; Fayon, L.; Joshi, R.; Kenda, B.; Khan, A.; Knapmeyer, M.; Lekic, V.; McClean, J.; Mimoun, D.; Murdoch, N.; Pan, L.; Perrin, C.; Pinot, B.; Pou, L.; Menina, S.; Rodriguez, S.; Schmelzbach, C.; Schmerr, N.; Sollberger, D.; Spiga, A.; Stähler, S.; Stott, A.; Stutzmann, E.; Tharimena, S.; Widmer-Schnidrig, R.; Schimmel, M.; Rodriguez Manfredi, J.A.
- Abstract
Mars’s seismic activity and noise have been monitored since January 2019 by the seismometer of the InSight (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) lander. At night, Mars is extremely quiet; seismic noise is about 500 times lower than Earth’s microseismic noise at periods between 4 s and 30 s. The recorded seismic noise increases during the day due to ground deformations induced by convective atmospheric vortices and ground-transferred wind-generated lander noise. Here we constrain properties of the crust beneath InSight, using signals from atmospheric vortices and from the hammering of InSight’s Heat Flow and Physical Properties (HP) instrument, as well as the three largest Marsquakes detected as of September 2019. From receiver function analysis, we infer that the uppermost 8–11 km of the crust is highly altered and/or fractured. We measure the crustal diffusivity and intrinsic attenuation using multiscattering analysis and find that seismic attenuation is about three times larger than on the Moon, which suggests that the crust contains small amounts of volatiles.
- Published
- 2020
22. New seismological constraints on the crustal structure of Mars and the Moon
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Knapmeyer‐Endrun, Brigitte, Panning, Mark P., Bissig, F., Joshi, Rakshit, Khan, A., Kim, Doyeon, Lekic, Vedran, Tauzin, Benoit, Tharimena, S., Plasman, Matthieu, Compaire, Nicolas, Garcia, Raphael F., Margerin, Ludovic, Schimmel, Martin, Stutzmann, E., Schmerr, Nicholas C., Antonangeli, D., Bozdag, E., McLennan, S., Peter, Daniel B., Plesa, A. C., Samuel, H., Wieczorek, M., Davis, Paul, Lognonné, P., Pinot, Baptiste, Scholz, J. R., Staehler, Simon C., Knapmeyer, M., Brinkman, N., van Driel, M., Giardini, Domenico, Johnson, C., Smrekar, S. E., Banerdt, William B., Knapmeyer‐Endrun, Brigitte, Panning, Mark P., Bissig, F., Joshi, Rakshit, Khan, A., Kim, Doyeon, Lekic, Vedran, Tauzin, Benoit, Tharimena, S., Plasman, Matthieu, Compaire, Nicolas, Garcia, Raphael F., Margerin, Ludovic, Schimmel, Martin, Stutzmann, E., Schmerr, Nicholas C., Antonangeli, D., Bozdag, E., McLennan, S., Peter, Daniel B., Plesa, A. C., Samuel, H., Wieczorek, M., Davis, Paul, Lognonné, P., Pinot, Baptiste, Scholz, J. R., Staehler, Simon C., Knapmeyer, M., Brinkman, N., van Driel, M., Giardini, Domenico, Johnson, C., Smrekar, S. E., and Banerdt, William B.
- Abstract
Planetary crusts are the results of mantle differentiation, so their thickness provides important constraints on the thermochemical evolution of a planet, including its heat budget and mantle rheology. Information on crustal layering and seismic velocities can also provide important constraints on porosity and geochemistry of the crust. Here, we use data from the InSight mission, which landed in November 2018, to provide seismological constraints on the crustal layering and thickness of Mars for the first time. Results are mainly based on Ps-receiver functions from three events with magnitudes between 3.1 and 3.6 at distances between 27.5° and 47° (±10°) from the lander, originating in the Cerberus Fossae region, the only events, so far, with clear, impulsive P-wave onsets and known epicenter. Ps-receiver functions use converted phases in the P-wave coda to derive information on discontinuities beneath the seismometer. Due to the limited number of events and the small epicentral distance range covered, inversions of the data are still ambiguous. Two sets of models can explain the waveforms, one consisting of a two-layer crust of about 20 to 23 km thickness, the other having a three-layer crust of about 40 to 45 km thickness. By excluding crustal thicknesses in excess of 45 km at the landing site, we can constrain the global average crustal thickness of Mars to be less than 70 km. Both model types also agree with S-receiver functions for two events and seismic P-waves reflected in the crust and extracted from autocorrelations using the coda of different types of marsquakes as well as the background wavefield. Furthermore, the results are compatible with independently conducted moment tensor inversions for a limited number of events as well as modeling of the wave-propagation of high-frequency events. We find low seismic P-wave velocities below 3.4 km/s within the upper approximately 10 km, likely indicating a high porosity. For the Moon, we present Sp-receiver functi
- Published
- 2020
23. Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data
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Centre National D'Etudes Spatiales (France), California Institute of Technology, NASA Astrobiology Institute (US), Swiss National Science Foundation, European Commission, Schimmel, Martin [0000-0003-2601-4462], Lognonné, P., Banerdt, W. B., Pike, William T., Giardini, Domenico, Christensen, U., Garcia, R. F., Kawamura, T., Kedar, S., Knapmeyer‐Endrun, Brigitte, Margerin, L., Nimmo, F., Daubar, I., Delage, P., Fuji, N., Golombek, M., Grott, M., Horleston, A., Hurst, K., Irving, J., Jacob, A., Knollenberg, J., Krasner, S., Krause, C., Lorenz, R., Michaut, C., Myhill, Robert, Nissen-Meyer, T., ten Pierick, J., Plesa, A. C., Quantin-Nataf, C., Robertsson, J., Rochas, L., Schimmel, Martin, Smrekar, S., Spohn, T., Teanby, N., Tromp, J., Vallade, J., Verdier, N., Vrettos, C., Weber, R., Banfield, D., Barrett, E., Bierwirth, M., Calcutt, S., Compaire, N., Johnson, C. L., Mance, D., Euchner, F., Kerjean, L., Mainsant, G., Mocquet, A., Rodriguez Manfredi, J. A., Pont, G., Laudet, P., Nebut, T., de Raucourt, S., Robert, O., Russell, C. T., Sylvestre-Baron, A., Tillier, S., Warren, T., Wieczorek, M., Yana, C., Zweifel, P., Panning, M., Tauzin, B., Scholz, J. R., Antonangeli, D., Barkaoui, S., Beucler, E., Bissig, F., Brinkman, N., Calvet, M., Ceylan, S., Charalambous, C., Davis, P., van Driel, M., Drilleau, M., Fayon, L., Joshi, R., Kenda, B., Khan, A., Knapmeyer, M., Lekic, Vedran, McClean, J., Mimoun, D., Murdoch, N., Pan, L., Perrin , C., Pinot, B, Pou, L., Menina, S., Rodríguez, S., Schmelzbach, C., Schmerr, N., Sollberger, D., Spiga, A., Stähler, S., Stott, A., Stutzmann, E., Tharimena, S., Widmer-Schnidrig, R., Andersson, F., Ansan, V., Beghein, C., Böse, M., Bozdag, E., Clinton, John F., Centre National D'Etudes Spatiales (France), California Institute of Technology, NASA Astrobiology Institute (US), Swiss National Science Foundation, European Commission, Schimmel, Martin [0000-0003-2601-4462], Lognonné, P., Banerdt, W. B., Pike, William T., Giardini, Domenico, Christensen, U., Garcia, R. F., Kawamura, T., Kedar, S., Knapmeyer‐Endrun, Brigitte, Margerin, L., Nimmo, F., Daubar, I., Delage, P., Fuji, N., Golombek, M., Grott, M., Horleston, A., Hurst, K., Irving, J., Jacob, A., Knollenberg, J., Krasner, S., Krause, C., Lorenz, R., Michaut, C., Myhill, Robert, Nissen-Meyer, T., ten Pierick, J., Plesa, A. C., Quantin-Nataf, C., Robertsson, J., Rochas, L., Schimmel, Martin, Smrekar, S., Spohn, T., Teanby, N., Tromp, J., Vallade, J., Verdier, N., Vrettos, C., Weber, R., Banfield, D., Barrett, E., Bierwirth, M., Calcutt, S., Compaire, N., Johnson, C. L., Mance, D., Euchner, F., Kerjean, L., Mainsant, G., Mocquet, A., Rodriguez Manfredi, J. A., Pont, G., Laudet, P., Nebut, T., de Raucourt, S., Robert, O., Russell, C. T., Sylvestre-Baron, A., Tillier, S., Warren, T., Wieczorek, M., Yana, C., Zweifel, P., Panning, M., Tauzin, B., Scholz, J. R., Antonangeli, D., Barkaoui, S., Beucler, E., Bissig, F., Brinkman, N., Calvet, M., Ceylan, S., Charalambous, C., Davis, P., van Driel, M., Drilleau, M., Fayon, L., Joshi, R., Kenda, B., Khan, A., Knapmeyer, M., Lekic, Vedran, McClean, J., Mimoun, D., Murdoch, N., Pan, L., Perrin , C., Pinot, B, Pou, L., Menina, S., Rodríguez, S., Schmelzbach, C., Schmerr, N., Sollberger, D., Spiga, A., Stähler, S., Stott, A., Stutzmann, E., Tharimena, S., Widmer-Schnidrig, R., Andersson, F., Ansan, V., Beghein, C., Böse, M., Bozdag, E., and Clinton, John F.
- Abstract
Mars’s seismic activity and noise have been monitored since January 2019 by the seismometer of the InSight (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) lander. At night, Mars is extremely quiet; seismic noise is about 500 times lower than Earth’s microseismic noise at periods between 4 s and 30 s. The recorded seismic noise increases during the day due to ground deformations induced by convective atmospheric vortices and ground-transferred wind-generated lander noise. Here we constrain properties of the crust beneath InSight, using signals from atmospheric vortices and from the hammering of InSight’s Heat Flow and Physical Properties (HP3) instrument, as well as the three largest Marsquakes detected as of September 2019. From receiver function analysis, we infer that the uppermost 8–11 km of the crust is highly altered and/or fractured. We measure the crustal diffusivity and intrinsic attenuation using multiscattering analysis and find that seismic attenuation is about three times larger than on the Moon, which suggests that the crust contains small amounts of volatiles.
- Published
- 2020
24. SEIS first year: nm/s^2 (and less) broadband seismology on Mars and first steps in Mars-Earth-Moon comparative seismology. (Invited)
- Author
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Lognonné, P., Banerdt, William B., Pike, William T., Giardini, Domenico, Banfield, D., Christensen, U., Beucler, E., Bierwirth, Marco, Calcutt, Simon B., Daubar, I., Clinton, John F., Kedar, S., Gabsi, T., Garcia, Raphael G., Hurst, K., Kawamura, T., Knapmeyer‐Endrun, Brigitte, Margerin, Ludovic, Mimoun, D., Nimmo, F., Panning, Mark P., De Raucourt, Sebastien, Schmerr, Nicholas C., Smrekar, Suzanne, Spiga, A., Teanby, Nicholas A., Weber, R. C., Wieczorek, M., Zweifel, Peter, Yana, C., Barkaoui, Salma, Brinkman, N., Ceylan, S., Conejero, Vicente, Compaire, Nicolas, Charalambous, C., Davis, Paul, van Driel, M., Drilleau, M., Fayon, Lucile, Kenda, B., Mance, Davor, McClean, John, Murdoch, N., Nebut, Tanguy, Pardo, Constanza, Pinot, Baptiste, Pou, Laurent, Perrin, C., Sainton, G., Sollberger, David, Scholz, J. R., Staehler, Simon C., Roberts, Oliver, Schmelzbach, C., Stott, A., Schimmel, Martin, Stutzmann, E., Tillier, Sylvain, Verdier, Nicolas, Warren, T., Widmer-Schnidrig, Rudolf, Böse, M., Euchner, F., Horleston, Anna C., Khan, A., Orhand-Mainsant, Guenolé, Barrett, E., Gaudin, E., Kerjean, Laurent, Julien, Agnès, Nonon, M., Llorca-Cejudo, R., Laudet, Philippe, Maki, Justin, Mouret, Jean-Marie, Pont, Gabriel, Meunier, Frederic A., Rochas, Ludovic, de Larclause, Isabel Savin, Sylvestre-Baron, Annick, Trebi-Ollenu, Ashitey, Valladeau, J., Delage, P., Jacob, A., Calvet, Marie, Grotte, M., Rodríguez-Manfredi, José Antonio, Lekic, Vedran, Menina, Sabrina, Robertsson, John O.A., Spohn, Tilman, Tauzin, Benoit, Tharimena, S., and Pierick, Jen Ten
- Abstract
AGU Fall Meeting 2019 in San Francisco , 9-13 December 2019, EIS/InSIght team, InSight is the first planetary mission with a seismometer package, SEIS, since the Apollo Lunar Surface Experiments Package. SEIS is complimented by APSS, which has as a goal to document the atmospheric source of seismic noise and signals. Since June 2019, SEIS has been delivering 6 axis 20 sps continuous seismic data, a rate one order of magnitude larger originally planned. More than 50 events have been detected by the end of July 2019 but only three have amplitudes significantly above the SEIS instrument requirement. Two have clear and coherent arrivals of P and S waves, enabling location, diffusion/attenuation characterization and receiver function analysis. The event¿s magnitudes are likely ¿ 3 and no clear surface waves nor deep interior phases have been identified. This suggests deep events with scattering along their final propagation paths and with large propagation differences as compared to Earth and Moon quakes. Most of the event¿s detections are made possible due to the very low noise achieved by the instrument installation strategy and the very low VBB self-noise. Most of the SEIS signals have amplitudes of spectral densities in the 0.03-5Hz frequency bandwidth ranging from 10-10 m/s2/Hz1/2 to 5 10-9 m/s2/Hz1/2. The smallest noise levels occurs during the early night, with angstrom displacements or nano-radian tilts. This monitors the elastic and seismic interaction of a planetary surface with its atmosphere, illustrated not only by a wide range of SEIS signals correlated with pressure vortexes, dust devils or wind activity but also by modulation of resonances above 1 Hz, amplified by ultra-low velocity surface layers. After about one half of a Martian year, clear seasonal changes appear also in the noise, which will be discussed. One year after landing, the seismic noise is therefore better and better understood, and noise correction techniques begun to be implemented, either thanks to the APSS wind and pressure sensors, or by SEIS only data processing techniques. These data processing techniques open not only the possibility of better signal to noise ratio of the events, but are also used for various noise auto-correlation techniques as well as searches of long period signals. Noise and seismic signals on Mars are therefore completely different from what seismology encountered previously on Earth and Moon.
- Published
- 2019
25. Detection of multiple waterborne pathogens using microsequencing arrays
- Author
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Brinkman, N. E., Francisco, R., Nichols, T. L., Robinson, D., Schaefer, F. W., III, Schaudies, R. P., and Villegas, E. N.
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- 2013
- Full Text
- View/download PDF
26. High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis
- Author
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Hoornenborg, Elske, primary, Coyer, Liza, additional, Boyd, Anders, additional, Achterbergh, Roel Christiaan Alfons, additional, Schim van der Loeff, Maarten Franciscus, additional, Bruisten, Sylvia, additional, de Vries, Henry John Christiaan, additional, Koopsen, Jelle, additional, van de Laar, Thijs J.W., additional, Prins, Maria, additional, van Bergen, J.E.A.M., additional, de Bree, G.J., additional, Brokx, P., additional, Deug, F., additional, Heidenrijk, M., additional, Prins, M., additional, Reiss, P., additional, van der Valk, M., additional, Davidovich, U., additional, Geerlings, S.E., additional, Hoornenborg, E., additional, Oomen, A., additional, Sighem, A. van, additional, Zuilhof, W., additional, Bruinderink, M.L. Groot, additional, Achterbergh, R.C.A., additional, van Agtmael, M., additional, Ananworanich, J., additional, Van de Beek, D., additional, van den Berk, G.E.L., additional, Bezemer, D., additional, van Bijnen, A., additional, Blok, W.L., additional, Bogers, S., additional, Bomers, M., additional, Boucher, C.A.B., additional, Brokking, W., additional, Burger, D., additional, Brinkman, K., additional, Brinkman, N., additional, de Bruin, M., additional, Bruisten, S., additional, Coyer, L., additional, van Crevel, R., additional, Daans, C.G., additional, Dellemann, L., additional, Dijkstra, M., additional, van Duijnhoven, Y.T., additional, van Eeden, A., additional, Elsenburg, L., additional, van den Elshout, M.A.M., additional, Ester, C., additional, Ersan, E., additional, Felipa, P.E.V., additional, Frissen, P.H.J., additional, Geijtenbeek, T.B.H., additional, Godfried, M.H., additional, van Gool, J., additional, Goorhuis, A., additional, Groot, M., additional, Hankins, C.A., additional, Heijnen, A., additional, Hillebregt, M.M.J., additional, Hogewoning, A., additional, Hommenga, M., additional, Hovius, J.W., additional, Janssen, Y., additional, de Jong, K., additional, Jongen, V., additional, Kootstra, N.A., additional, Koup, R.A., additional, Kroon, F.P., additional, van de Laar, T.J.W., additional, Lauw, F., additional, van Leeuwen, M.M., additional, Lettinga, K., additional, Linde, I., additional, Loomans, D.S.E., additional, van der Meer, J.T., additional, Mouhebati, T., additional, Mulder, B.J., additional, Mulder, J., additional, Nellen, F.J., additional, Nijsters, A., additional, Nobel, H., additional, Oostvogel, P., additional, Op de Coul, E.L.M., additional, Peters, E., additional, Peters, I.S., additional, van der Poll, T., additional, Ratmann, O., additional, Rokx, C., additional, van Rooijen, M.S., additional, Schim van der Loeff, M.F., additional, Schoute, W.E.M., additional, Sonder, G.J., additional, Veenstra, J., additional, Verbon, A., additional, Verdult, F., additional, de Vocht, J., additional, de Vries, H.J., additional, Vrouenraets, S., additional, van Vugt, M., additional, Wiersinga, W.J., additional, Wit, F.W., additional, Woittiez, L.R., additional, Zaheri, S., additional, Zantkuijl, P., additional, van Zelm, M.C., additional, Żakowicz, A., additional, and Zimmermann, H.M.L., additional
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- 2020
- Full Text
- View/download PDF
27. Is reaching 90-90-90 enough to end AIDS? Lessons from Amsterdam
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Bree, G.J. de, Sighem, A. van, Zuilhof, W., Bergen, J.E.A.M. van, Prins, M., Heidenrijk, M., Valk, M. van der, Brokx, P., Reiss, P., Deug, F., Davidovich, U., Geerlings, S.E., Hoornenborg, E., Oomen, A., Bruinderink, M.L.G., Schat, N., Achterbergh, R.C.A., Agtmael, M. van, Ananworanich, J., Beek, D. van de, Berk, G.E.L. van den, Bezemer, D., Bijnen, A. van, Blok, W.L., Bogers, S., Bomers, M., Boucher, C.A.B., Brokking, W., Burger, D., Brinkman, K., Brinkman, N., Bruin, M. de, Bruisten, S., Coyer, L., Crevel, R. van, Daans, C.G., Derckx, T., Dijkstra, M., Duijnhoven, Y.T. van, Eeden, A. van, Elsenburg, L., Elshout, M.A.M. van den, Ester, C., Ersan, E., Felipa, P.E.V., Geijtenbeek, T.B.H., Gool, J. van, Goorhuis, A., Groot, M., Hankins, C.A., Heijnen, A., Hillebregt, M.M.J., Hogewoning, A., Hommenga, M., Hovius, J.W., Janssen, Y., Jong, K. de, Jongen, V., Kootstra, N.A., Koup, R.A., Kroon, F.P., Laar, T.J.W. van de, Lauw, F., Leeuwen, M.M. van, Lettinga, K., Linde, I., Loomans, D.S.E., Mouhebati, T., Mulder, B.J., Mulder, J., Nellen, F.J., Nijsters, A., Nobel, H., Oostvogel, P., Coul, E.L.M. op de, Peters, E., Peters, I.S., Poll, T. van der, Ratmann, O., Rokx, C., Rooijen, M.S. van, Loeff, M.F.S. van der, Schoute, W.E.M., Sonder, G.J., Veenstra, J., Verbon, A., Vries, H.J. de, Vrouenraets, S., Vugt, M. van, Wiersinga, W.J., Wit, F.W., Zaheri, S., Zantkuijl, P., Zelm, M.C. van, Zakowicz, A., Zimmermann, H.M.L., HIV Transmission Elimination, Virology, and Internal Medicine
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Anti-HIV Agents ,Immunology ,Human immunodeficiency virus (HIV) ,MEDLINE ,Hiv testing ,medicine.disease_cause ,epidemic ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,SDG 3 - Good Health and Well-being ,Virology ,Environmental health ,Medicine ,Humans ,030212 general & internal medicine ,Amsterdam ,Hiv transmission ,Netherlands ,Acquired Immunodeficiency Syndrome ,Oncology (nursing) ,business.industry ,Transmission (medicine) ,Public health ,virus diseases ,HIV ,Hematology ,Integrated approach ,medicine.disease ,030104 developmental biology ,Infectious Diseases ,Oncology ,business - Abstract
Purpose of review Although cities present opportunities for infectious pathogens such as HIV to spread, public health infrastructure within these cities also provides opportunities to design effective approaches to eliminate transmission of these pathogens. The HIV Transmission Elimination AMsterdam (H-TEAM) Initiative, a consortium of relevant stakeholders involved in HIV prevention and care, designed an integrated approach to curb the HIV epidemic in Amsterdam, including providing preexposure prophylaxis (PrEP), increasing awareness of acute HIV infection, offering same-day test and treat, and improving indicator disease-driven HIV testing. Recent findings In 2013, approximately 230 people in Amsterdam were newly diagnosed with HIV, largely belonging to one of two key affected populations, namely MSM and people with a migration background. Since the start of H-TEAM in 2014, a decrease in new diagnoses was observed (130 in 2017), with an increasing proportion of MSM who had been diagnosed with a recent infection. Summary The H-TEAM shows that a city-based concerted effort is feasible. However, major challenges remain, such as reducing the number of late HIV diagnoses, and identifying and providing appropriate services to a diminishing group of individuals who are likely the source of transmission.
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- 2019
28. Preparing for InSight: Evaluation of the Blind Test for Martian Seismicity
- Author
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Swiss National Science Foundation, Centre National D'Etudes Spatiales (France), Swiss National Supercomputing Centre, Schimmel, Martin [0000-0003-2601-4462], van Driel, M., Ceylan, S., Clinton, John F., Giardini, Domenico, Alemany, H., Allam, A., Ambrois, David, Balestra, J., Banerdt, B., Becker, D., Böse, M., Boxberg, M. S., Brinkman, N., Casademont, T., Chèze, Jérôme, Daubar, I., Deschamps, Anne, Dethof, F., Ditz, M., Drilleau, M., Essing, D., Euchner, F., Fernando, B., García, Raphael, Garth, T., Godwin, H, Golombek, M. P., Grunert, Klaus G., Hadziioannou, C., Haindl, C., Hammer, C., Hochfeld, I., Hosseini, K., Hu, Hao, Kedar, S., Kenda, B., Khan, A., Kilchling, T., Knapmeyer‐Endrun, Brigitte, Lamert, A., Li, J. X., Lognonné, P., Mader, S., Marten, L., Mehrkens, F., Mercerat, D., Mimoun, D., Moller, T., Murdoch, N., Neumann, P., Neurath, R., Paffrath, M., Panning, M.P., Peix, F., Perrin, L., Rolland, L., Schimmel, Martin, Schroer, C., Spiga, A., Stahler, S. C., Steinmann, R., Stutzmann, E., Szenicer, A., Trumpik, N., Tsekhmistrenko, M., Twardzik, C., Weber, R., Werdenbach-Jarklowski, P., Zhang, S., Zheng, Y. C., Swiss National Science Foundation, Centre National D'Etudes Spatiales (France), Swiss National Supercomputing Centre, Schimmel, Martin [0000-0003-2601-4462], van Driel, M., Ceylan, S., Clinton, John F., Giardini, Domenico, Alemany, H., Allam, A., Ambrois, David, Balestra, J., Banerdt, B., Becker, D., Böse, M., Boxberg, M. S., Brinkman, N., Casademont, T., Chèze, Jérôme, Daubar, I., Deschamps, Anne, Dethof, F., Ditz, M., Drilleau, M., Essing, D., Euchner, F., Fernando, B., García, Raphael, Garth, T., Godwin, H, Golombek, M. P., Grunert, Klaus G., Hadziioannou, C., Haindl, C., Hammer, C., Hochfeld, I., Hosseini, K., Hu, Hao, Kedar, S., Kenda, B., Khan, A., Kilchling, T., Knapmeyer‐Endrun, Brigitte, Lamert, A., Li, J. X., Lognonné, P., Mader, S., Marten, L., Mehrkens, F., Mercerat, D., Mimoun, D., Moller, T., Murdoch, N., Neumann, P., Neurath, R., Paffrath, M., Panning, M.P., Peix, F., Perrin, L., Rolland, L., Schimmel, Martin, Schroer, C., Spiga, A., Stahler, S. C., Steinmann, R., Stutzmann, E., Szenicer, A., Trumpik, N., Tsekhmistrenko, M., Twardzik, C., Weber, R., Werdenbach-Jarklowski, P., Zhang, S., and Zheng, Y. C.
- Abstract
In December 2018, the National Aeronautics and Space Administration (NASA) Interior exploration using Seismic Investigations, Geodesy and Heat Transport (InSight) mission deployed a seismometer on the surface of Mars. In preparation for the data analysis, in July 2017, the marsquake service initiated a blind test in which participants were asked to detect and characterize seismicity embedded in a one Earth year long synthetic data set of continuous waveforms. Synthetic data were computed for a single station, mimicking the streams that will be available from InSight as well as the expected tectonic and impact seismicity, and noise conditions on Mars (Clinton et al., 2017). In total, 84 teams from 20 countries registered for the blind test and 11 of them submitted their results in early 2018. The collection of documentations, methods, ideas, and codes submitted by the participants exceeds 100 pages. The teams proposed well established as well as novel methods to tackle the challenging target of building a global seismicity catalog using a single station. This article summarizes the performance of the teams and highlights the most successful contributions.
- Published
- 2019
29. The first active seismic experiment on Mars to characterize the shallow subsurface structure at the InSight landing site
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Brinkman, N., primary, Schmelzbach, C., additional, Sollberger, D., additional, van Driel, M., additional, ten Pierick, J., additional, Robertsson, J. O. A., additional, Andersson, F., additional, Stähler, S., additional, Giardini, D., additional, Kedar, S., additional, Hudson, T., additional, Hurst, K., additional, KiVely, A., additional, Banerdt, W. B., additional, Grott, M., additional, Spohn, T., additional, Krause, C., additional, Fayon, L., additional, Lognonné, P., additional, Knapmeyer-Endrun, B., additional, Delage, P., additional, Pike, W. T., additional, Horleston, A., additional, Teanby, N., additional, and Vretto, C., additional
- Published
- 2019
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30. Exhaust Emissions, Fuel Economy, and Driveability of Vehicles Fueled with Alcohol-Gasoline Blends
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Brinkman, N. D., Gallopoulos, N. E., and Jackson, M. W.
- Published
- 1975
31. Enhancing Low-Temperature Phase Stability of a 50/50 Methanol/Hydrocarbon Blend
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Lee, H. K., Shah, D. O., and Brinkman, N. D.
- Published
- 1988
32. Evaluatie toekomst- en onderzoeksagenda Tweede Kamer der Staten-Generaal
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Boogers, Marcel, van Klaveren, S.M., Pons, A.G.A., Brinkman, N., Plat, T., Meys, N.M., Public Administration, and Faculty of Behavioural, Management and Social Sciences
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METIS-312297 ,IR-97734 - Published
- 2015
33. Timber Management Guide for Shortleaf Pine and Oak-Pine Types in Missouri
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K. A. Brinkman, N. F. Rogers and K. A. Brinkman, N. F. Rogers
- Published
- 1967
34. Performance Evaluation of 10% Ethanol-Gasoline Blends in 1980 Model Year U.S. Cars
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Bernstein, L. S., primary, Brinkman, N. D., additional, and Carlson, R. R., additional
- Published
- 1982
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35. Effect of Fuel Volatility on Driveability at Low and intermediate Ambient Temperatures
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Brinkman, N. D., primary, Steinke, E. D., additional, Villforth, F. J., additional, and Williams, W. C., additional
- Published
- 1983
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36. Gasoline Vapor Pressure Reduction-an Option for Cleaner Air
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Stebar, R. F., primary, Benson, J. D., additional, Brinkman, N. D., additional, Dunker, A. M., additional, Sapre, A. R., additional, Schwing, R. C., additional, and Martens, S. W., additional
- Published
- 1985
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37. Vehicle Evaluation of Neat Methanol--Compromises among Exhaust Emissions, Fuel Economy and Driveability
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Brinkman, N. D.
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- *
METHANOL - Published
- 1979
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38. Effect of compression ratio on exhaust emissions and performance of a methanol-fueled single-cylinder engine
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Brinkman, N
- Published
- 1980
39. CORR Insights®: Does a Concise Patient-reported Outcome Measure Provide a Valid Measure of Physical Function for Cancer Patients After Lower Extremity Surgery?
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Brinkman N
- Abstract
Competing Interests: The author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request.
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- 2024
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40. Is It Possible to Develop a Patient-reported Experience Measure With Lower Ceiling Effect?
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Brinkman N, Looman R, Jayakumar P, Ring D, and Choi S
- Abstract
Background: Patient-reported experience measures (PREMs), such as the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE) or the Wake Forest Trust in Physician Scale (WTPS), have notable intercorrelation and ceiling effects (the proportion of observations with the highest possible score). Information is lost when high ceiling effects occur as there almost certainly is at least some variation among the patients with the highest score that the measurement tool was unable to measure. Efforts to identify and quantify factors associated with diminished patient experience can benefit from a PREM with more variability and a smaller proportion of highest possible scores (that is, a more limited ceiling effect) than occurs with currently available PREMs., Questions/purposes: In the first stage of a two-stage process, using a cohort of patients seeking musculoskeletal specialty care, we asked: (1) What groupings of items that address a similar aspect of patient experience are present among binary items directed at patient experience and derived from commonly used PREMs? (2) Can a small number of representative items provide a measure with potential for less of a ceiling effect (high item difficulty parameters)? In a second, independent cohort enrolled to assess whether the identified items perform consistently among different cohorts, we asked: (3) Does the new PREM perform differently in terms of item groupings (factor structure), and would different subsets of the included items provide the same measurement results (internal consistency) when items are measured using a 5-point rating scale instead of a binary scale? (4) What are the differences in survey properties (for example, ceiling effects) and correlation between the new PREM and commonly used PREMs?, Methods: In two cross-sectional studies among patients seeking musculoskeletal specialty care conducted in 2022 and 2023, all English-speaking and English-reading adults (ages 18 to 89 years) without cognitive deficiency were invited to participate in two consecutive, separate cohorts to help develop (the initial, learning cohort) and internally validate (the second, validation cohort) a provisional new PREM. We identified 218 eligible patients for the initial learning cohort, of whom all completed all measures. Participants had a mean ± SD age of 55 ± 16 years, 60% (130) were women, 45% (99) had private insurance, and most sought care for lower extremity (56% [121]) and nontraumatic conditions (63% [137]). We measured 25 items derived from other commonly used PREMs that address aspects of patient experience in which patients reported whether they agreed or disagreed (binary) with certain statements about their clinician. We performed an exploratory factor analysis and confirmatory factor analysis (CFA) to identify groups of items that measure the same underlying construct related to patient experience. We then applied a two-parameter logistic model based on item response theory to identify the most discriminating items with the most variability (item difficulty) with the aim of reducing the ceiling effect. We also conducted a differential item functioning analysis to assess whether specific items are rated discordantly by specific subgroups of patients, which can introduce bias. We then enrolled 154 eligible patients, of whom 99% (153) completed all required measures, into a validation cohort with similar demographic characteristics. We changed the binary items to 5-point Likert scales to increase the potential for variation in an attempt to further reduce ceiling effects and repeated the CFA. We also measured internal consistency (using Cronbach alpha) and the correlation of the new PREM with other commonly used PREMs using bivariate analyses., Results: We identified three groupings of items in the learning cohort representing "trust in clinician" (13 items), "relationship with clinician" (7 items), and "participation in shared decision-making" (4 items). The "trust in clinician" factor performed best of all three factors and therefore was selected for subsequent analyses. We selected the best-performing items in terms of item difficulty to generate a 7-item short form. We found excellent CFA model fit (the 13-item and 7-item versions both had a root mean square error of approximation [RMSEA] of < 0.001), excellent internal consistency (Cronbach α was 0.94 for the 13-item version and 0.91 for the 7-item version), good item response theory parameters (item difficulty ranging between -0.37 and 0.16 for the 7-item version, with higher values indicating lower ceiling effect), no local dependencies, and no differential item functioning among any of the items. The other two factors were excluded from measure development due to low item response theory parameters (item difficulty ranging between -1.3 and -0.69, indicating higher ceiling effect), multiple local dependencies, and exhausting the number of items without being able to address these issues. The validation cohort confirmed adequate item selection and performance of both the 13-item and 7-item version of the Trust and Experience with Clinicians Scale (TRECS), with good to excellent CFA model fit (RMSEA 0.058 [TRECS-13]; RMSEA 0.016 [TRECS-7]), excellent internal consistency (Cronbach α = 0.96 [TRECS-13]; Cronbach α = 0.92 [TRECS-7]), no differential item functioning and limited ceiling effects (11% [TRECS-13]; 14% [TRECS-7]), and notable correlation with other PREMs such as the JSPPPE (ρ = 0.77) and WTPS (ρ = 0.74)., Conclusion: A relatively brief 7-item measure of patient experience focused on trust can eliminate most of the ceiling effects common to PREMs with good psychometric properties. Future studies may externally validate the TRECS in other populations as well as provide population-based T-score conversion tables based on a larger sample size more representative of the population seeking musculoskeletal care., Clinical Relevance: A PREM anchored in trust that reduces loss of information at the higher end of the scale can help individuals and institutions to assess experience more accurately, gauge the impact of interventions, and generate effective ways to learn and improve within a health system., Competing Interests: Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request., (Copyright © 2024 by the Association of Bone and Joint Surgeons.)
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- 2024
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41. Most Carpal Tunnel Releases Address Moderate or Severe Median Neuropathy.
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Brinkman N, Chandler C, Ring D, Vagner G, and Reichel L
- Abstract
Background: The role of surgery in normal or very mild median neuropathy can be questioned given that surgery in the absence of pathophysiology may offer only nonspecific effects that can be achieved without surgery, which raises ethical concerns. It's also important to avoid misdiagnosis: given that mild median neuropathy is prevalent and generally well-accommodated, notable symptoms from mild median neuropathy can signal unhelpful thoughts and feelings of distress that are a more pressing health priority., Methods: We identified 38 studies that categorized electrodiagnostic (EDX) measured median neuropathy severity among people being evaluated for carpal tunnel syndrome. We converted the different EDX grades used into one general grading classification. The Kruskal-Wallis test was used to compare the ratio of moderate/severe to mild/normal EDX findings between tests ordered by a surgeon or a nonoperative clinician., Results: The median (interquartile range) ratio of moderate/severe to mild/normal EDX findings of median neuropathy at the carpal tunnel was 1.2 (0.91 to 1.8) among tests ordered by nonoperative clinicians and 3.3 (1.5 to 5.3) among tests ordered by surgeons ( P = .0023). Only 4.1% of the patients who had EDX testing ordered by a surgeon had no measurable neuropathy. There were zero patients with normal EDX findings in 10 of the 17 (59%) studies in surgeon practices and in 10 of the 21 (48%) in the practices of nonoperative clinicians., Conclusions: The observation that in case series documenting EDX severities of median neuropathy, surgeons are mostly treating and operating on moderate to severe pathophysiology, emphasizes that while mild median neuropathy is highly prevalent it is uncommonly considered for surgery., Level of Evidence: Level II, Prognostic study., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: DR received royalties from Skeletal Dynamics for an internal joint stabilizer elbow and from Wolters Kluwer. DR is a deputy editor for Hand and Wrist and Clinical Orthopaedics and Related Research.® DR received honoraria from various CME providers, hospitals, and universities.
- Published
- 2024
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42. Surgeon Factors Rather Than Patient Factors Account for Variation in Recommended Treatment Strategy for Patients With Multiligament Knee Injury.
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Brinkman N, Nunziato C, Laverty D, Ring D, Hill A, and Crijns TJ
- Subjects
- Humans, Male, Female, Cross-Sectional Studies, Adult, Middle Aged, Orthopedic Surgeons, Ligaments, Articular surgery, Ligaments, Articular injuries, Knee Injuries surgery, Practice Patterns, Physicians' statistics & numerical data
- Abstract
Objectives: To seek the factors associated with timing, staging, and type of surgery in the management of multiligament knee injuries., Design: Cross-sectional scenario-based experiment., Setting: Fifteen fictional patient scenarios with randomized elements., Participants: Fracture surgeons of the Science of Variation Group, an international collaborative of musculoskeletal surgeons who studies variation in care, were invited to participate. Surgeons with limited experience treating multiligament knee injuries were asked to self-exclude., Outcome Measures and Comparisons: Surgeon recommendations for operative treatment, timing of surgery, and use of open surgery in addition to arthroscopy were measured. Patient factors (age, time from injury, contralateral fracture, knee dislocation, combinations of ruptured ligaments, and preexisting osteoarthritis) and surgeon factors (gender, practice location, years of experience, and supervision of trainees) associated with surgeon recommendations were assessed., Results: Eighty-five surgeons participated, of which most were men (89%) and practiced in the United States (44%) or Europe (38%). Operative treatment was less likely among older patients (odds ratio [OR] = 0.051) and preexisting osteoarthritis (OR = 0.32) and more likely in knee dislocation (OR = 1.9) and disruption of anterior cruciate ligament, posterior cruciate ligament, and lateral collateral ligament with or without medial collateral ligament (MCL; OR = 5.1 and OR = 3.1, respectively). Disruption of anterior cruciate ligament, posterior cruciate ligament, and medial collateral ligament was associated with shorter time to surgery (β = -11). Longer time to surgery was associated with contralateral fracture (β = 9.2) and surgeons supervising trainees (β = 23) and practicing in Europe (β = 13). Surgeon factors accounted for more variation in timing than patient and injury factors (5.1% vs. 1.4%, respectively). Open surgery was more likely in patients with lateral collateral ligament injury (OR = 2.9 to 3.3)., Conclusions: The observation that surgeons were more likely to operate in younger patients with more severe injury has face validity, while the finding that surgeon factors accounted for more variation in timing of surgery than patient or injury factors suggests that treatment variation is based on opinion more so than evidence., Level of Evidence: Prognostic Level V. See Instructions for Authors for a complete description of levels of evidence., Competing Interests: D. Ring reports other from Skeletal Dynamics, personal fees from Deputy Editor for Clinical Orthopaedics and Related Research, personal fees from Universities and Hospitals, personal fees from Lawyers, personal fees from Health Services and Resource Administration and Department of Justice, personal fees from Premier Healthcare Solutions, personal fees from Wolters Kluwer Health, grants from National Institutes for Health, personal fees from Everus, other from MyMedicalHub, outside the submitted work. The remaining authors report no conflict of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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43. Recovery of Comfort and Capability After Upper Extremity Fracture Is Predominantly Associated With Mindset: A Longitudinal Cohort From the United Kingdom.
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Brinkman N, Thomas JE, Teunis T, Ring D, Gwilym S, and Jayakumar P
- Subjects
- Humans, Female, Male, Middle Aged, Longitudinal Studies, United Kingdom, Adult, Aged, Fractures, Bone psychology, Cohort Studies, Pain Measurement, Radius Fractures psychology, Radius Fractures surgery, Shoulder Fractures psychology, Recovery of Function
- Abstract
Objectives: To determine the relative influence of mindset and fracture severity on 9-month recovery trajectories of pain and capability after upper extremity fractures., Design: Secondary use of longitudinal data., Setting: Single Level-1 trauma center in Oxford, United Kingdom., Patient Selection: English-speaking adults with isolated proximal humerus, elbow, or distal radius fracture managed operatively or nonoperatively were included, and those with multiple fractures or cognitive deficit were excluded., Outcome Measures and Comparisons: Incapability (Quick-DASH) and pain intensity (11-point rating scale) were measured at baseline, 2-4 weeks, and 6-9 months after injury. Cluster analysis was used to identify statistical groupings of mindset (PROMIS Depression and Anxiety, Pain Catastrophizing Scale, and Tampa Scale for Kinesiophobia) and fracture severity (low/moderate/high based on OTA/AO classification). The recovery trajectories of incapability and pain intensity for each mindset grouping were assessed, accounting for various fracture-related aspects., Results: Among 703 included patients (age 59 ± 21 years, 66% women, 16% high-energy injury), 4 statistical groupings with escalating levels of distress and unhelpful thoughts were identified (fracture severity was omitted considering it had no differentiating effect). Groups with less healthy mindset had a worse baseline incapability (group 2: β = 4.1, 3: β = 7.5, and 4: β = 17) and pain intensity (group 3: β = 0.70 and 4: β = 1.4) (P < 0.01). Higher fracture severity (β = 4.5), high-energy injury (β = 4.0), and nerve palsy (β = 8.1) were associated with worse baseline incapability (P < 0.01), and high-energy injury (β = 0.62) and nerve palsy (β = 0.76) with worse baseline pain intensity (P < 0.01). Groups 3 and 4 had a prolonged rate of recovery of incapability (β = 1.3, β = 7.0) and pain intensity (β = 0.19, β = 1.1) (P < 0.02)., Conclusions: Patients with higher levels of unhelpful thinking and feelings of distress regarding symptoms experienced worse recovery of pain and incapability, with a higher effect size than fracture location, fracture severity, high-energy injury, and nerve palsy. These findings underline the importance of anticipating and addressing mental health concerns during recovery from injury., Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence., Competing Interests: The authors report no conflict of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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44. Associations of Mental, Social and Pathophysiological factors with Pain Intensity and Capability in Patients with Shoulder Osteoarthritis Prior to Shoulder Arthroplasty: A Dutch Arthroplasty Register study.
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Broekman M, Brinkman N, Thomas JE, Doornberg J, Spekenbrink-Spooren A, Gosens T, Ring D, and van den Bekerom M
- Abstract
Background: Mounting evidence suggests that mental health accounts for greater variation in levels of comfort and capability than pathophysiology severity across a range of musculoskeletal conditions. Using nationwide Dutch Arthroplasty Register (LROI) data, we tested the null hypothesis that none of the available mental, social, and pathophysiological factors are associated with variation in levels of comfort and capability among people with shoulder osteoarthritis prior to arthroplasty., Methods: We included all adult patients who underwent primary total shoulder arthroplasty for osteoarthritis in the period 2014-2021 with complete measures of shoulder specific capability (Oxford Shoulder Score), pain intensity (10-point Numeric Rating Scale), general wellbeing (the EQ-5D 3-L), the grade of pathophysiology (Walch classification) and categorized social health based on a social deprivation index. In total, 1342 patients with shoulder osteoarthritis preparing for shoulder arthroplasty were included in a regression analysis to seek factors associated with variation in levels of pain intensity and capability., Results: Greater pain intensity at rest was associated with greater symptoms of anxiety and depression (Regression Coefficient [RC] = -0.41; 95% Confidence Interval [CI] = 0.17 to 0.64; P = <0.01), and women (RC = 0.38; 95% CI = 0.11 to 0.66; P = <0.01). Greater incapability was associated with greater symptoms of anxiety and depression (RC = -3.2; 95% CI = -4.0 to -2.4; P = <0.01), an ASA score of III and IV (RC = -3.1; 95% CI = -4.8 to -1.4; P = <0.01), older age (RC = -0.098; 95% CI = -0.15 to -0.047; P = <0.01), and women (RC = -3.9; 95% CI = -4.9 to -3.0; P = <0.01). Neither comfort nor capability were associated with Walch classification or social deprivation index., Conclusion: The confirmation that variation in levels of comfort and capability among people preparing for shoulder arthroplasty are associated with mindset rather than a measure of glenoid pathophysiology points to the potential benefits of addressing mental health in musculoskeletal health strategies., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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45. Surgeon Prioritization of Mental, Social, and Pathophysiological Aspects of Health Among People With Traumatic and Nontraumatic Musculoskeletal Conditions.
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Broekman M, Brinkman N, Davids F, van den Bekerom M, Ring D, Doornberg J, Ramtin S, and Jayakumar P
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Surgeons psychology, Musculoskeletal Diseases physiopathology, Musculoskeletal Diseases psychology, Mental Health
- Abstract
Background: There is mounting evidence that, among musculoskeletal patients, variation in capability has more notable associations with variations in mental and social health factors than with variation in pathophysiology severity. This study sought factors that could limit the integration of this evidence into more comprehensive care models., Methods: In two scenario-based experiments, surgeon participants in an international collaborative, the Science of Variation Group, reviewed scenarios of (a) nontraumatic (83 participants) and (b) trauma-related (130 participants) pathophysiologies for which tests and treatments were discretionary. The following demographic, mental, and social health elements were varied randomly: sex, age, race/ethnicity, mindsets, social health aspects, and specific pathophysiologies. For each scenario, participants rated their likelihood to offer surgery (continuous) and their sense of presence of an opportunity to address better mental or social health in treatment (yes or no). Factors associated with each rating were sought in multivariable analysis., Results: Greater likelihood to offer discretionary surgery for nontraumatic pathophysiologies was associated with greater pathophysiology severity, trapeziometacarpal arthritis, and greater distress and unhelpful thoughts regarding symptoms. Lateral elbow enthesopathy was associated with a lower likelihood. For trauma-related pathophysiologies, an ankle fracture with slight articular subluxation was associated with greater likelihood to offer surgery, and several other trauma-related pathophysiologies were associated with a lower likelihood. For both nontraumatic and trauma-related pathophysiologies, surgeons noticed unhelpful thinking, distress, and social issues as reasons to consider addressing mental and social health in treatment, relatively independent of pathophysiology., Conclusion: Surgeons seem to recognize opportunities to address mental and social needs but ultimately base their decision to offer discretionary surgery on pathophysiological factors., Clinical Relevance: Comprehensive, whole-person care for musculoskeletal illness might be supported by strategies for ensuring that aspects of stress and distress that contribute to greater symptom intensity are not misinterpreted as a reflection of greater pathophysiology severity., (Copyright © 2024 by the American Academy of Orthopaedic Surgeons.)
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- 2024
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46. Reply to the Letter to the Editor: Variations in 1-year Trajectories of Levels of Pain and Capability After Shoulder Arthroplasty Are Associated With Baseline Mental Health.
- Author
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Brinkman N, Ring D, and van den Bekerom M
- Subjects
- Humans, Shoulder Pain etiology, Shoulder Pain surgery, Pain Measurement, Treatment Outcome, Pain, Postoperative etiology, Time Factors, Recovery of Function, Arthroplasty, Replacement, Shoulder adverse effects, Mental Health, Shoulder Joint surgery, Shoulder Joint physiopathology
- Abstract
Competing Interests: Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research ® editors and board members are on file with the publication and can be viewed on request.
- Published
- 2024
- Full Text
- View/download PDF
47. Is the feeling of 'weakness' associated with unhelpful thoughts or distress regarding symptoms?
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Davids FA, Brinkman N, Broekman MM, Ring D, Reichel LM, and Vagner GA
- Abstract
This cross-sectional study looked for factors associated with feelings of weakness, level of capability and pain intensity in people seeking musculoskeletal speciality care for non-traumatic upper extremity conditions. A survey was conducted in 139 English-speaking adults, with 135 participants completing it. We found that greater intensity of feelings of weakness correlated with higher distress regarding symptoms and with older age. Lower level of capability was associated with greater intensity of feelings of weakness, greater distress regarding symptoms and older age. Higher pain intensity was associated with greater distress regarding symptoms and greater intensity of feelings of weakness. These findings suggest that the symptom of weakness may be a cue to explore potential distress about symptoms in addition to examining for actual weakness. This understanding could be a guide to a more compassionate approach to alleviate distress rather than focusing on neuromuscular pathophysiology alone, with the potential to reduce unnecessary tests and treatments. Level of evidence: IV., Competing Interests: Declaration of conflicting interestsThe authors disclosed the following potential conflicts of interest with respect to her research, authorship, and/or publication of this article: DR certifies receipt of personal payments or benefits, during the study period, in an amount of less than US$1000 from Wolters-Kluwer and less than US$100,000 from Skeletal Dynamics. All other authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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48. Preoperative Symptoms of Depression are Associated With Worse Capability 6-weeks and 6-months After Total Hip Arthroplasty for Osteoarthritis.
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Sauder N, Brinkman N, Sayegh GE, Moore MG, Koenig KM, Bozic KJ, Patel JJ, and Jayakumar P
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Prospective Studies, Preoperative Period, Surveys and Questionnaires, Recovery of Function, Treatment Outcome, Arthroplasty, Replacement, Hip psychology, Arthroplasty, Replacement, Hip adverse effects, Osteoarthritis, Hip surgery, Osteoarthritis, Hip psychology, Depression etiology, Depression psychology
- Abstract
Background: Symptoms of depression have been associated with greater incapability following total hip arthroplasty (THA). A brief, 2-question, measure of symptoms of depression - the Patient Health Questionnaire-2 (PHQ-2) - may be sufficient to measure associations with the magnitude of incapability during recovery from THA. This study investigated whether preoperative symptoms of depression (measured with the PHQ-2) correlated with levels of incapability 6 weeks and 6 months after THA, accounting for demographic and clinical factors., Methods: We performed a prospective cohort study across 5 centers and recruited 101 patients undergoing THA, of whom 90 (89%) completed follow-up. Patients completed demographics, a preoperative 2-item (PHQ-2) measure of symptoms of depression, and the Hip Dysfunction and Osteoarthritis Outcome Score for Joint Replacement (HOOS JR) at 6-weeks and 6-months postoperatively. Negative binomial regression models determined factors associated with HOOS JR at 6 weeks and 6 months, accounting for potential confounders., Results: Accounting for potential confounding factors, we found that higher preoperative PHQ-2 scores (reflecting greater symptoms of depression) were associated with lower HOOS JR scores (reflecting a greater level of hip disability) at both 6 weeks (regression coefficient = -0.67, P < .001) and 6 months (regression coefficient = -1.9, P < .001) after THA., Conclusions: Symptoms of depression on a 2-question preoperative questionnaire are common, and greater symptoms of depression are associated with reduced capability within the first year following THA. These findings support the prioritization of routine mental health assessments before THA. Measuring mindset using relatively brief instruments will be important considering the current shift toward implementing self-reported measures of health status in clinical practice and incorporating them within alternative payment models., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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49. A Small Number of Surgeons Perform the Large Majority of Uncommon Nerve Decompression Procedures.
- Author
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Brinkman N, Ramtin S, Ring D, and Adams JE
- Abstract
Background: Notable surgeon-to-surgeon variation in rates of uncommon surgery can reflect appropriate concentration of expertise with technically difficult or risky procedures that address problematic impairment due to objective pathophysiology. Examples include vascularized tissue transfer or transplantation to address complex tissue loss and release of bony elbow ankylosis. Perhaps more problematic is notable variation in straightforward, discretionary surgeries intended to alleviate pain, offered in the absence of objectively measurable pathophysiology, and without experimental evidence of benefit over placebo and other nonspecific effects. Evidence of concentration of this type of surgery in the hands of a few surgeons might point to inordinate influence of surgeon opinions on patient behavior. A study of variation in operations for upper extremity peripheral mononeuropathy has the potential to uncover potentially problematic variation. There are billing codes specific to common surgeries that can benefit patients with objectively verifiable neuropathies. And there are billing codes that represent less common nerve decompression surgeries that in many cases are offered in the absence of both objective evidence of pathophysiology as well as experimental evidence that surgery alleviates pain better than simulated surgery., Questions/purposes: We asked the following questions: (1) Among surgeons who billed a mean of at least 10 carpal tunnel releases (CTRs) per year in patients with Medicare insurance in the United States, how many also performed at least one less common peripheral nerve release and cubital tunnel release (CubTR) per year? (2) Among surgeons who billed a mean of at least one less common peripheral nerve release or CubTR on average per year, what is the median and range of the number of less common peripheral nerve releases and CubTRs and the relative proportion of these compared with CTRs per year? (3) Are there any differences in gender, specialty, and number of CTRs and CubTRs between surgeons who performed at least one less common nerve decompression and surgeons who, on average, performed none?, Methods: Using the Medicare Physician & Other Practitioners - by Provider and Service database, we identified surgeons who perform a minimum of 10 CTRs per year. Because this database has all surgeries billed to Medicare performed in any setting by individual surgeons, it is well suited to the study of surgeon-specific operative rates among Medicare patients. Among 7259 clinicians who billed one or more nerve procedure to Medicare between January 2013 and December 2019, we excluded 120 nonsurgical clinicians, 47 podiatrists, and 1561 clinicians who billed procedures as an organization. Among the remaining 5531 surgeons, 5439 performed at least 10 CTRs on average per year, which we considered representative of surgeons who include nerve decompression surgery as a part of their practice. Among these 5439 surgeons, we calculated the mean number of CTRs, CubTRs, and less common peripheral nerve releases (including decompression of a digital nerve, nerve in hand or wrist, ulnar nerve at the wrist, brachial plexus, and unspecified nerve) per year between 2013 and 2019. Decompression of the median nerve at the carpal tunnel, the ulnar nerve at the cubital tunnel, and, much less frequently, the ulnar nerve at the wrist typically addresses measurable neuropathy. The other nerve releases are often performed for illnesses characterized by pain that are defined, in part, by the absence of experimentally verifiable pathophysiology such as radial tunnel and pronator (or lacertus) syndromes. We counted the number of surgeons who billed an average of at least one less common peripheral nerve release and CubTR per year; the median and range of the number of less common nerve releases and CubTRs and their relative proportion among those subsets of surgeons; and differences in the number of surgeons who performed one or none less common surgery by gender, specialty, and volume of CTR/CubTR surgery., Results: Of 5439 surgeons who performed a mean of at least 10 CTRs per year, 2% (93) performed a mean of at least one less common peripheral nerve release per year among patients on Medicare, 14% (775) at least one CubTR, and 1% (47) performed both. Surgeons who performed a mean of at least one less common peripheral nerve release per year performed a median (IQR) of 7 (3 to 17) per year (with a maximum of 153 per year), representing approximately one less common peripheral nerve release for every five CTRs. Sixty-five percent (4076 of 6272) of all less common nerve procedures were performed by the top 20 billing surgeons. Gender was not associated with doing one or more uncommon nerve releases (women 1% [6 of 413], men 2% [87 of 5026]; p = 0.84), but specialty was, with plastic surgeons leading (6% [20 of 340] compared with 1% [73 of 5087] for other types of surgeons; p < 0.001)., Conclusion: The observation that a relatively small number of surgeons perform a large majority of the surgery for nerve syndromes conceptualized as accounting for arm pain suggests that most surgeons are cautious about ascribing pain to conceptual nerve compression syndromes and offering surgery., Clinical Relevance: An approach to surgical care founded on ethical principles regards this type of notable variation as a signal of inordinate influence of surgeon opinion on patient behavior, suggesting that professional conduct may be supported by safeguards such as checklists that help guide patients to choices consistent with their values unclouded by surgeon beliefs, false hope, and common misconceptions., Competing Interests: All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research® editors and board members are on file with the publication and can be viewed on request., (Copyright © 2024 by the Association of Bone and Joint Surgeons.)
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- 2024
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50. Capability After Total Knee Arthroplasty for Osteoarthritis Is Strongly Associated With Preoperative Symptoms of Depression.
- Author
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Sayegh GE, Sauder N, Brinkman N, Moore MLG, Bozic KJ, Patel J, Koenig KM, and Jayakumar P
- Subjects
- Humans, Female, Male, Aged, Prospective Studies, Middle Aged, Cohort Studies, Treatment Outcome, Arthroplasty, Replacement, Knee, Osteoarthritis, Knee surgery, Osteoarthritis, Knee psychology, Depression etiology, Preoperative Period
- Abstract
Background: Primary total knee arthroplasty (TKA) aims to improve the level of capability (ability to perform valued life activities) associated with knee osteoarthritis (OA). However, some evidence suggests a substantial proportion of patients remain dissatisfied with their outcomes after this procedure. We sought to better understand the association between mental health, specifically symptoms of depression, with postoperative outcomes. Symptoms of depression are shown to be common among orthopaedic populations in general and can be briefly and conveniently evaluated using the Patient Health Questionnaire-2 (PHQ-2) in a less burdensome manner compared with longer mental health surveys. This study assesses the association between preoperative depressive symptoms (PHQ-2) and levels of capability at 6 weeks and 6 months after TKA., Methods: We conducted a prospective cohort study involving 114 patients with knee OA across five clinics in California and Texas scheduled for TKA. Participants completed a preoperative PHQ-2 and Knee Injury and OA Outcome Score for Joint Replacement (KOOS JR) survey at 6 weeks and 6 months post-TKA. We analyzed these data using bivariate and multivariable regression., Results: Preoperative PHQ-2 scores were significantly associated with lower KOOS JR scores at 6 weeks and 6 months post-TKA. Latino/Hispanic race was also associated with lower KOOS JR scores at 6 weeks. The association between preoperative depressive symptoms and level of capability after TKA were more pronounced at 6 months compared with 6 weeks., Conclusion: Preoperative symptoms of depression are strongly associated with reduced capability after TKA and can be screened for using the PHQ-2-a brief tool that can be feasibly incorporated into clinical workflows. User-friendly assessment of depressive symptoms can assist orthopaedic surgeons in identifying and addressing mental health at the outset during the management of knee OA., (Copyright © 2024 by the American Academy of Orthopaedic Surgeons.)
- Published
- 2024
- Full Text
- View/download PDF
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