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3. A Search for Low-mass Dark Matter via Bremsstrahlung Radiation and the Migdal Effect in SuperCDMS

Author

SuperCDMS Collaboration, Al-Bakry, Musaab, Alkhatib, Imran, Amaral, Dorian Praia do, Aralis, Taylor, Aramaki, Tsuguo, Arnquist, Isaac, Langroudy, Iman Ataee, Azadbakht, Elham, Banik, Samir, Bathurst, Corey, Bauer, Dan, Bezerra, Lucas, Bhattacharyya, Rik, Brink, Paul, Bunker, Ray, Cabrera, Blas, Calkins, Robert, Cameron, Robert, Cartaro, Concetta, Cerdeno, David, Chang, Yen-Yung, Chaudhuri, Mouli, Chen, Ran, Chott, Nicholas, Cooley, Jodi, Coombes, Harrison, Corbett, Jonathan, Cushman, Priscilla, De Brienne, François, Dharani, Sukeerthi, di Vacri, Maria Laura, Diamond, Miriam, Fascione, Eleanor, Figueroa, Enectali, Fink, Caleb, Fouts, Ken, Fritts, Matt, Gerbier, Gilles, Germond, Richard, Ghaith, Muad, Golwala, Sunil, Hall, Jeter, Hassan, Noah, Hines, Bruce, Hollister, Matt, Hong, Ziqing, Hoppe, Eric, Hsu, Lauren, Huber, Martin, Iyer, Vijay, Jardin, Daniel, Jastram, Andrew, Kashyap, Varchaswi, Kelsey, Michael, Kubik, Andrew, Kurinsky, Noah, Lawrence, Richard, Lee, Matthew, Li, Ashley, Liu, Jasmine, Liu, Yan, Loer, Ben, Lukens, Pat, MacFarlane, David, Mahapatra, Rupak, Mandic, Vuk, Mast, Nicholas, Mayer, Adam, Theenhausen, Hanno Meyer zu, Michaud, Émile, Michielin, Emanuele, Mirabolfathi, Nader, Mohanty, Bedangadas, Nagorny, Serge, Nelson, Jack, Neog, Himangshu, Novati, Valentina, Orrell, John, Osborne, McKay, Oser, Scott, Page, William, Partridge, Richard, Pedreros, David S., Podviianiuk, Ruslan, Ponce, Francisco, Poudel, Sudip, Pradeep, Aditi, Pyle, Matt, Rau, Wolfgang, Reid, Elliott, Ren, Tom, Reynolds, Tyler, Roberts, Amy, Robinson, Alan, Saab, Tarek, Sadoulet, Bernard, Saikia, Ishwita, Sander, Joel, Sattari, Ata, Schmidt, Benjamin, Schnee, Richard, Scorza, Silvia, Serfass, Bruno, Poudel, Sagar Sharma, Sincavage, Derek, Stanford, Chris, Street, Joseph, Sun, Huanbo, Thasrawala, Fatema, Toback, David, Underwood, Ryan, Verma, Shubham, Villano, Anthony, von Krosigk, Belina, Watkins, Samuel, Wen, Osmond, Williams, Zachary, Wilson, Matthew, Winchell, Joshua, Wu, Chih-pan, Wykoff, Kevin, Yellin, Steve, Young, Betty, Yu, To Chin, Zatschler, Birgit, Zatschler, Stefan, Zaytsev, Alexander, Zhang, Enze, Zheng, Lei, and Zuber, Summer

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

In this paper, we present a re-analysis of SuperCDMS data using a profile likelihood approach to search for sub-GeV dark matter particles (DM) through two inelastic scattering channels: bremsstrahlung radiation and the Migdal effect. By considering possible inelastic scattering channels, experimental sensitivity can be extended to DM masses that would otherwise be undetectable through the DM-nucleon elastic scattering channel, given the energy threshold of current experiments. We exclude DM masses down to $220~\textrm{MeV}/c^2$ at $2.7 \times 10^{-30}~\textrm{cm}^2$ via the bremsstrahlung channel. The Migdal channel search excludes DM masses down to $30~\textrm{MeV}/c^2$ at $5.0 \times 10^{-30}~\textrm{cm}^2$., Comment: This paper is being withdrawn due to an error in data selection during the analysis. Although incorrect, the limits are roughly representative of the sensitivity. The new corrected version of the result will be uploaded once ready

Published
2022

8. Effects of antidepressant exposure on aquatic communities assessed by a combination of morphological identification, functional measurements, environmental DNA metabarcoding and bioassays

Author

Schuijt, Lara M., van Smeden, Jasper, van Drimmelen, Chantal K.E., Buijse, Laura L., Wu, Dailing, Boerwinkel, Marie-Claire, Belgers, Dick J.M., Matser, Arrienne M., Roessink, Ivo, Heikamp-de Jong, Ineke, Beentjes, Kevin K., Trimbos, Krijn B., Smidt, Hauke, and Van den Brink, Paul J.

Published
2024
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14. Energy Loss Due to Defect Formation from $^{206}$Pb Recoils in SuperCDMS Germanium Detectors

Author

Agnese, Robert, Aralis, Taylor, Aramaki, Tsuguo, Arnquist, Isaac, Azadbakht, Elham, Baker, William, Banik, Samir, Barker, D'Ann, Bauer, Dan, Binder, Thomas, Bowles, Michael, Brink, Paul, Bunker, Ray, Cabrera, Blas, Calkins, Robert, Cartaro, Concetta, Cerdeno, David, Chang, Yen-Yung, Cooley, Jodi, Cornell, Brett, Cushman, Priscilla, Di Stefano, Philippe, Doughty, Todd, Fascione, Eleanor, Figueroa, Tali, Fink, Caleb, Fritts, Matt, Gerbier, Gilles, Germond, Richard, Ghaith, Muad, Golwala, Sunil, Harris, Rusty, Hong, Ziqing, Hoppe, Eric, Hsu, Lauren, Huber, Martin, Iyer, Vijay, Jardin, Dan, Jena, Chitrasen, Kelsey, Michael, Kennedy, Allison, Kubik, Andrew, Kurinsky, Noah, Lawrence, Richard, Loer, Ben, Lopez-Asamar, Elias, Lukens, Pat, MacDonell, Danika, Mahapatra, Rupak, Mandic, Vuk, Mast, Nicholas, Miller, Eric, Mirabolfathi, Nader, Mohanty, Bedangadas, Morales, Jorge, Nelson, Jack, Orrell, John, Oser, Scott, Page, William, Partridge, Richard, Pepin, Mark, Ponce, Francisco, Poudel, Sudip, Pyle, Matt, Qiu, Hang, Rau, Wolfgang, Reisetter, Angela, Ren, Tom, Reynolds, Tyler, Roberts, Amy, Robinson, Alan, Rogers, Hannah, Saab, Tarek, Sadoulet, Bernard, Sander, Joel, Scarff, Andrew, Schnee, Richard, Scorza, Silvia, Senapati, Kartik, Serfass, Bruno, Speller, Danielle, Stein, Matthew, Street, Joseph, Tanaka, Hirohisa, Toback, David, Underwood, Ryan, Villano, Anthony, von Krosigk, Belina, Watkins, Samuel, Wilson, Jon, Wilson, Matthew, Winchell, Joshua, Wright, Dennis, Yellin, Steve, Young, Betty, Zhang, Xiaohe, and Zhao, Xuji

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, Physics - Applied Physics
Abstract

The Super Cryogenic Dark Matter Search experiment (SuperCDMS) at the Soudan Underground Laboratory studied energy loss associated with Frenkel defect formation in germanium crystals at mK temperatures using in situ $^{210}$Pb sources. We examine the spectrum of $^{206}$Pb nuclear recoils near its expected 103 keV endpoint energy and determine an energy loss of $\left(6.08\pm0.18\right)$ %, which we attribute to defect formation. From this result and using TRIM simulations, we extract the first experimentally determined average displacement threshold energy of $\left(19.7^{+0.6}_{-0.5}\right)$ eV for germanium. This has implications for the analysis thresholds of future germanium-based dark matter searches., Comment: 4 Figures, Two data files, One data release description file

Published
2018
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18. SuperCDMS SNOLAB Low-Mass Detectors: Ultra-Sensitive Phonon Calorimeters for a Sub-GeV Dark Matter Search

Author

Kurinsky, Noah, Brink, Paul, Partridge, Richard, Cabrera, Blas, and Pyle, Matt

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We present the technical design for the SuperCDMS high-voltage, low-mass dark matter detectors, designed to be sensitive to dark matter down to 300 MeV/$c^2$ in mass and resolve individual electron-hole pairs from low-energy scattering events in high-purity Ge and Si crystals. In this paper we discuss some of the studies and technological improvements which have allowed us to design such a sensitive detector, including advances in phonon sensor design and detector simulation. With this design we expect to achieve better than 10 eV (5 eV) phonon energy resolution in our Ge (Si) detectors, and recoil energy resolution below 1eV by exploiting Luke-Neganov phonon generation of charges accelerated in high fields., Comment: 4 Pages, 3 figures, proceedings of the 38th International Conference on High Energy Physics (ICHEP), Chicago, IL, USA

Published
2016

21. Integrating climate model projections into environmental risk assessment: A probabilistic modeling approach

Author

Moe, S. Jannicke, primary, Brix, Kevin V., additional, Landis, Wayne G., additional, Stauber, Jenny L., additional, Carriger, John F., additional, Hader, John D., additional, Kunimitsu, Taro, additional, Mentzel, Sophie, additional, Nathan, Rory, additional, Noyes, Pamela D., additional, Oldenkamp, Rik, additional, Rohr, Jason R., additional, van den Brink, Paul J., additional, Verheyen, Julie, additional, and Benestad, Rasmus E., additional

Published
2024
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24. Growth of alpha-beta phase W thin films over steep Al topography in a confocal sputtering machine

Author

Kreikebaum, John Mark, Cabrera, Blas, Yen, Jeff, Brink, Paul, Tomada, Astrid, Cherry, Matt, and Young, Betty

Subjects
Condensed Matter - Materials Science
Abstract

We report on thin-film processing improvements in the fabrication of superconducting quasiparticle-trap-assisted electrothermal-feedback transition-edge sensors (QETs) used in the design of Cryogenic Dark Matter Search (CDMS) detectors. The work was performed as part of a detector upgrade project that included optimization of a new confocal sputtering system and development of etch recipes compatible with patterning 40 nm-thick, mixed-phase W films deposited on 300-600 nm-thick, patterned Al. We found that our standard exothermic Al wet etch recipes provided inadequate W/Al interfaces and led to poor device performance. We developed a modified Al wet-etch recipe that effectively mitigates geometrical step-coverage limitations while maintaining our existing device design. Data presented here include SEM and FIB images of films and device interfaces obtained with the new Al etch method. We also introduce a method for quantitatively measuring the energy collection efficiency through these interfaces., Comment: 9 pages; 7 figures

Published
2014

29. Evaluating the effects of climate change and chemical, physical, and biological stressors on nearshore coral reefs: A case study in the Great Barrier Reef, Australia.

Author

Mentzel, Sophie, Nathan, Rory, Noyes, Pamela, Brix, Kevin V., Moe, S. Jannicke, Rohr, Jason R., Verheyen, Julie, Van den Brink, Paul J., and Stauber, Jennifer

Subjects
CORAL reefs & islands, CORAL bleaching, CORALS, ECOLOGICAL risk assessment, REEFS, ENVIRONMENTAL risk assessment, COASTS, CYCLONES
Abstract

An understanding of the combined effects of climate change (CC) and other anthropogenic stressors, such as chemical exposures, is essential for improving ecological risk assessments of vulnerable ecosystems. In the Great Barrier Reef, coral reefs are under increasingly severe duress from increasing ocean temperatures, acidification, and cyclone intensities associated with CC. In addition to these stressors, inshore reef systems, such as the Mackay–Whitsunday coastal zone, are being impacted by other anthropogenic stressors, including chemical, nutrient, and sediment exposures related to more intense rainfall events that increase the catchment runoff of contaminated waters. To illustrate an approach for incorporating CC into ecological risk assessment frameworks, we developed an adverse outcome pathway network to conceptually delineate the effects of climate variables and photosystem II herbicide (diuron) exposures on scleractinian corals. This informed the development of a Bayesian network (BN) to quantitatively compare the effects of historical (1975–2005) and future projected climate on inshore hard coral bleaching, mortality, and cover. This BN demonstrated how risk may be predicted for multiple physical and biological stressors, including temperature, ocean acidification, cyclones, sediments, macroalgae competition, and crown of thorns starfish predation, as well as chemical stressors such as nitrogen and herbicides. Climate scenarios included an ensemble of 16 downscaled models encompassing current and future conditions based on multiple emission scenarios for two 30‐year periods. It was found that both climate‐related and catchment‐related stressors pose a risk to these inshore reef systems, with projected increases in coral bleaching and coral mortality under all future climate scenarios. This modeling exercise can support the identification of risk drivers for the prioritization of management interventions to build future resilient reefs. Integr Environ Assess Manag 2024;20:401–418. © 2023 Norwegian Institute for Water Research and The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. Key Points: We developed a Bayesian network (BN) to explore how climate model projections can be incorporated into environmental risk assessment (ERA) for a coral reef ecosystem, supported by adverse outcome pathways.This case study has demonstrated the potential of BNs to incorporate climate variables into ERAs to predict risks of combined stressors.The BN predicted a higher probability of climate and catchment stressors, causing increased coral bleaching and mortality, under all future climate scenarios. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Using a Bayesian Network Model to Predict Risk of Pesticides on Aquatic Community Endpoints in a Rice Field—A Southern European Case Study.

Author

Mentzel, Sophie, Martínez‐Megías, Claudia, Grung, Merete, Rico, Andreu, Tollefsen, Knut Erik, Van den Brink, Paul J., and Moe, S. Jannicke

Subjects
PESTICIDES, INSECTICIDES, BAYESIAN analysis, PADDY fields, MCPA (Herbicide), BIOPESTICIDES, ENVIRONMENTAL toxicology
Abstract

Bayesian network (BN) models are increasingly used as tools to support probabilistic environmental risk assessments (ERAs), because they can better account for uncertainty compared with the simpler approaches commonly used in traditional ERA. We used BNs as metamodels to link various sources of information in a probabilistic framework, to predict the risk of pesticides to aquatic communities under given scenarios. The research focused on rice fields surrounding the Albufera Natural Park (Valencia, Spain), and considered three selected pesticides: acetamiprid (an insecticide), 2‐methyl‐4‐chlorophenoxyacetic acid (MCPA; a herbicide), and azoxystrobin (a fungicide). The developed BN linked the inputs and outputs of two pesticide models: a process‐based exposure model (Rice Water Quality [RICEWQ]), and a probabilistic effects model (Predicts the Ecological Risk of Pesticides [PERPEST]) using case‐based reasoning with data from microcosm and mesocosm experiments. The model characterized risk at three levels in a hierarchy: biological endpoints (e.g., molluscs, zooplankton, insects, etc.), endpoint groups (plants, invertebrates, vertebrates, and community processes), and community. The pesticide risk to a biological endpoint was characterized as the probability of an effect for a given pesticide concentration interval. The risk to an endpoint group was calculated as the joint probability of effect on any of the endpoints in the group. Likewise, community‐level risk was calculated as the joint probability of any of the endpoint groups being affected. This approach enabled comparison of risk to endpoint groups across different pesticide types. For example, in a scenario for the year 2050, the predicted risk of the insecticide to the community (40% probability of effect) was dominated by the risk to invertebrates (36% risk). In contrast, herbicide‐related risk to the community (63%) resulted from risk to both plants (35%) and invertebrates (38%); the latter might represent (in the present study) indirect effects of toxicity through the food chain. This novel approach combines the quantification of spatial variability of exposure with probabilistic risk prediction for different components of aquatic ecosystems. Environ Toxicol Chem 2024;43:182–196. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Temperature induced changes in species distribution increases sensitivity of aquatic invertebrate communities to chemicals.

Author

Van den Brink, Paul J.

Subjects
*INVERTEBRATE communities, *SPECIES distribution, *AQUATIC invertebrates, *GLOBAL warming, *POLLUTANTS, *FRESHWATER biodiversity, *PHYSIOLOGICAL adaptation
Abstract

This article discusses the potential impact of climate warming on the sensitivity of aquatic invertebrate communities to chemical stressors. The study by Sinclair et al. (2024) examines the effects of climate-induced changes in species composition on the future sensitivity of these communities to chemical pollution. The researchers predict that shifts in species composition due to climate warming will increase the risk of chemical pollution, potentially doubling or quadrupling the impact on freshwater macroinvertebrate biodiversity by the end of the 21st century. The article highlights the need to consider the indirect interactions between climate warming and chemical toxicity, particularly the influence of temperature on species distribution and sensitivity. [Extracted from the article]

Published
2024
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36. Relationships of temperature and biodiversity with stability of natural aquatic food webs

Author

Zhao, Qinghua, primary, Van den Brink, Paul J., additional, Xu, Chi, additional, Wang, Shaopeng, additional, Clark, Adam T., additional, Karakoç, Canan, additional, Sugihara, George, additional, Widdicombe, Claire E., additional, Atkinson, Angus, additional, Matsuzaki, Shin-ichiro S., additional, Shinohara, Ryuichiro, additional, He, Shuiqing, additional, Wang, Yingying. X. G., additional, and De Laender, Frederik, additional

Published
2023
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37. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, primary, Barbieri, Miriam, additional, Shiti, Assad, additional, Casini, Simona, additional, Sager, Philip T, additional, Das, Saumya, additional, Pradhananga, Sabindra, additional, Srinivasan, Dinesh, additional, Nimani, Saranda, additional, Alerni, Nicolò, additional, Louradour, Julien, additional, Mura, Manuela, additional, Gnecchi, Massimiliano, additional, Brink, Paul, additional, Zehender, Manfred, additional, Koren, Gideon, additional, Zaza, Antonio, additional, Crotti, Lia, additional, Wilde, Arthur A M, additional, Schwartz, Peter J, additional, Remme, Carol Ann, additional, Gepstein, Lior, additional, Sala, Luca, additional, and Odening, Katja E, additional

Published
2023
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39. The NORMAN Association and the European Partnership for Chemicals Risk Assessment (PARC): let’s cooperate!

Author

Dulio, Valeria, Koschorreck, Jan, van Bavel, Bert, van den Brink, Paul, Hollender, Juliane, Munthe, John, Schlabach, Martin, Aalizadeh, Reza, Agerstrand, Marlene, Ahrens, Lutz, Allan, Ian, Alygizakis, Nikiforos, Barcelo’, Damia’, Bohlin-Nizzetto, Pernilla, Boutroup, Susanne, Brack, Werner, Bressy, Adèle, Christensen, Jan H., Cirka, Lubos, Covaci, Adrian, Derksen, Anja, Deviller, Geneviève, Dingemans, Milou M. L., Engwall, Magnus, Fatta-Kassinos, Despo, Gago-Ferrero, Pablo, Hernández, Félix, Herzke, Dorte, Hilscherová, Klára, Hollert, Henner, Junghans, Marion, Kasprzyk-Hordern, Barbara, Keiter, Steffen, Kools, Stefan A. E., Kruve, Anneli, Lambropoulou, Dimitra, Lamoree, Marja, Leonards, Pim, Lopez, Benjamin, López de Alda, Miren, Lundy, Lian, Makovinská, Jarmila, Marigómez, Ionan, Martin, Jonathan W., McHugh, Brendan, Miège, Cécile, O’Toole, Simon, Perkola, Noora, Polesello, Stefano, Posthuma, Leo, Rodriguez-Mozaz, Sara, Roessink, Ivo, Rostkowski, Pawel, Ruedel, Heinz, Samanipour, Saer, Schulze, Tobias, Schymanski, Emma L., Sengl, Manfred, Tarábek, Peter, Ten Hulscher, Dorien, Thomaidis, Nikolaos, Togola, Anne, Valsecchi, Sara, van Leeuwen, Stefan, von der Ohe, Peter, Vorkamp, Katrin, Vrana, Branislav, and Slobodnik, Jaroslav

Published
2020
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44. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, Barbieri, Miriam, Shiti, Assad, Casini, Simona, Sager, Philip T, Das, Saumya, Pradhananga, Sabindra, Srinivasan, Dinesh, Nimani, Saranda, Alerni, Nicolò, Louradour, Julien, Mura, Manuela, Gnecchi, Massimiliano, Brink, Paul, Zehender, Manfred, Koren, Gideon, Zaza, Antonio, Crotti, Lia, Wilde, Arthur A M, Schwartz, Peter J, Remme, Carol Ann, Gepstein, Lior, Sala, Luca, Odening, Katja E, Giannetti, F, Barbieri, M, Shiti, A, Casini, S, Sager, P, Das, S, Pradhananga, S, Srinivasan, D, Nimani, S, Alerni, N, Louradour, J, Mura, M, Gnecchi, M, Brink, P, Zehender, M, Koren, G, Zaza, A, Crotti, L, Wilde, A, Schwartz, P, Remme, C, Gepstein, L, Sala, L, and Odening, K

Subjects
Cellular electrophysiology, Physiology (medical), LQTS, Animal model, 610 Medicine & health, 610 Medizin und Gesundheit, Cardiology and Cardiovascular Medicine, Genotype-specific therapy, hiPSC, Mechanism-based therapy
Abstract

Aims Current long QT syndrome (LQTS) therapy, largely based on beta-blockade, does not prevent arrhythmias in all patients; therefore, novel therapies are warranted. Pharmacological inhibition of the serum/glucocorticoid-regulated kinase 1 (SGK1-Inh) has been shown to shorten action potential duration (APD) in LQTS type 3. We aimed to investigate whether SGK1-Inh could similarly shorten APD in LQTS types 1 and 2. Methods and results Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and hiPSC-cardiac cell sheets (CCS) were obtained from LQT1 and LQT2 patients; CMs were isolated from transgenic LQT1, LQT2, and wild-type (WT) rabbits. Serum/glucocorticoid-regulated kinase 1 inhibition effects (300 nM–10 µM) on field potential durations (FPD) were investigated in hiPSC-CMs with multielectrode arrays; optical mapping was performed in LQT2 CCS. Whole-cell and perforated patch clamp recordings were performed in isolated LQT1, LQT2, and WT rabbit CMs to investigate SGK1-Inh (3 µM) effects on APD. In all LQT2 models across different species (hiPSC-CMs, hiPSC-CCS, and rabbit CMs) and independent of the disease-causing variant (KCNH2-p.A561V/p.A614V/p.G628S/IVS9-28A/G), SGK1-Inh dose-dependently shortened FPD/APD at 0.3–10 µM (by 20–32%/25–30%/44–45%). Importantly, in LQT2 rabbit CMs, 3 µM SGK1-Inh normalized APD to its WT value. A significant FPD shortening was observed in KCNQ1-p.R594Q hiPSC-CMs at 1/3/10 µM (by 19/26/35%) and in KCNQ1-p.A341V hiPSC-CMs at 10 µM (by 29%). No SGK1-Inh-induced FPD/APD shortening effect was observed in LQT1 KCNQ1-p.A341V hiPSC-CMs or KCNQ1-p.Y315S rabbit CMs at 0.3–3 µM. Conclusion A robust SGK1-Inh-induced APD shortening was observed across different LQT2 models, species, and genetic variants but less consistently in LQT1 models. This suggests a genotype- and variant-specific beneficial effect of this novel therapeutic approach in LQTS.

Published
2023

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