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Cough is an important symptom of asthma. The objective assessment of chronic cough has been enhanced by the development of ambulatory cough monitoring systems. Mepolizumab has been demonstrated to reduce exacerbations in eosinophilic asthmatics long-term. We evaluate the utility of objective cough count as an outcome measure in severe eosinophilic asthma treated with mepolizumab. Consecutive, consenting patients initiated on treatment with mepolizumab had a 24-h cough count recorded at baseline; this was repeated at 1, 3 and 6 months. Asthma control questionnaire (ACQ) scores and exacerbation frequency were also recorded. The mean 24-h cough count in 11 subjects (8 females, mean age 53.6 years) was 172.4 at baseline; at 1, 3 and 6 months following initiation of treatment this decreased to 101.4, 92 and 70.8, respectively (p < 0.02). Significant improvements were also observed in mean ACQ score (3-1.6, p < 0.01) and exacerbation frequency (5.5 per year - 1.3, p < 0.01). Objective cough measurement could be used as an early, precise and clinically relevant endpoint in assessing response to asthma therapy., Author(s): Shoaib Faruqi [sup.1], Dominic L. Sykes [sup.1], Michael G. Crooks [sup.1], Kayleigh Brindle [sup.1], Joanne Thompson [sup.1], Alyn H. Morice [sup.1] Author Affiliations: (1) grid.9481.4, 0000 0004 0412 8669, [...]

Aim: The aim of this study was to systematically search and synthesise findings from peer-reviewed qualitative studies describing the experiences of those living with chronic cough., Methods: A systematic search was conducted to identify all studies that used qualitative methodology to report on the experiences of adults living with chronic cough. A thematic synthesis of the first-hand narratives was undertaken. Key themes in relation to personal perspectives and experiences of living with chronic cough were identified and grouped into analytical themes., Results: Six studies met the inclusion criteria. The thematic synthesis generated three analytical themes: 1) "It's just a cough"; 2) "Constant cough and constant worry"; and 3) "No light at the end of the tunnel", highlighting the biopsychosocial nature of chronic cough. The synthesis highlights chronic cough as a heterogeneous experience that may appear idiosyncratic, completely consuming the lives of those living with it., Conclusion: This is to our knowledge the first qualitative synthesis reporting on the perceptions and experiences of adults living with chronic cough. Our review draws attention to the paucity of literature that utilises qualitative methodology to explore the experience of living with chronic cough. We highlight the missing voice of people living with chronic cough in the contemporary literature. There is now a requirement for research exploring the narratives of those living with chronic cough, to gain an understanding of the condition beyond simple quantification., Competing Interests: Conflict of Interest: K. Brindle reports payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events received from MSD outside the submitted work. Conflict of Interest: A. Morice reports the following relationships outside the submitted work: grants or contracts received from MSD, Bayer, Shionogi, Bellus and NeRRe; royalties or licences from the HARQ questionnaire; payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events received from MSD; and payment for expert testimony received from NICE. He is the chair of the task force on chronic cough for the European Respiratory Society and an associate editor of this journal outside of this submitted work. Conflict of Interest: N. Carter, D. Sykes and M. Zhang have nothing to disclose Conflict of Interest: A. Hilton declares grants or contracts from the NIHR, payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from HU UK conference LTD, and is a member of the ACBS outside of the submitted work., (Copyright ©The authors 2023.)

Therapeutic antitussive effect of octreotide on intractable cough https://bit.ly/3mVMEc6., Competing Interests: Conflict of interest: A.H. Morice reports the following disclosures outside the submitted work: royalties or licences for HARQ, copyright held by University of Hull; support for attending meeting from AIST; editorial board member of ERJ Open Research. Conflict of interest: The remaining authors have nothing to disclose., (Copyright ©The authors 2023.)