469 results on '"Brindisi, Margherita"'
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2. Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform!
3. Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
4. Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route
5. Methyl-Transferase-Like Protein 16 (METTL16): The Intriguing Journey of a Key Epitranscriptomic Player Becoming an Emerging Biological Target.
6. Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
7. A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
8. A green Heck reaction protocol towards trisubstituted alkenes, versatile pharmaceutical intermediates.
9. Unveiling the modulation of Pseudomonas aeruginosa virulence and biofilm formation by selective histone deacetylase 6 inhibitors
10. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
11. Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems
12. Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors
13. Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
14. A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicansStrain, Computational Investigation and in Vivo Validation in a Galleria mellonellaFungal Infection Model
15. Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
16. Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects
17. Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex
18. First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents
19. Identification of novel fluorescent probes preventing PrPSc replication in prion diseases
20. Dealing with schistosomiasis: Current drug discovery strategies
21. Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
22. Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation
23. Development of novel cyclic peptides as pro-apoptotic agents
24. In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors
25. Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
26. Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents
27. Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis
28. A stereoselective approach to peptidomimetic BACE1 inhibitors
29. Editorial: Multi-target directed ligands for the treatment of cancer
30. Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution
31. Front Cover: Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution (ChemSusChem 6/2022)
32. Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology
33. Exploring the structural determinants for inhibitor selectivity towards the BACE protein family using structure-based molecular design
34. Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction
35. Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors
36. Coupling Interrupted Fischer and Multicomponent Joullié‐Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics
37. Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
38. Disease-Modifying Anti-Alzheimerʼs Drugs: Inhibitors of Human Cholinesterases Interfering with β-Amyloid Aggregation
39. Breakthroughs in medicinal chemistry: new targets and mechanisms, new drugs, new hopes-7
40. Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds
41. Flow synthesis approaches to privileged scaffolds – recent routes reviewed for green and sustainable aspects
42. Developing β–secretase inhibitors for treatment of Alzheimerʼs disease
43. Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
44. Targeting Endocannabinoid Metabolism: an Arrow with Multiple Tips Against Multiple Sclerosis
45. Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
46. Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials
47. Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds
48. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry
49. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells
50. Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the “primer grip” region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants
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