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BackgroundGlobal efforts are needed to elucidate the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the underlying cause of coronavirus disease 2019 (COVID-19), including seroprevalence, risk factors, and long-term sequelae, as well as immune responses after vaccination across populations and the social dimensions of prevention and treatment strategies.MethodsIn the United States, the National Cancer Institute in partnership with the National Institute of Allergy and Infectious Diseases, established the SARS-CoV-2 Serological Sciences Network (SeroNet) as the nation's largest coordinated effort to study coronavirus disease 2019. The network comprises multidisciplinary researchers bridging gaps and fostering collaborations among immunologists, epidemiologists, virologists, clinicians and clinical laboratories, social and behavioral scientists, policymakers, data scientists, and community members. In total, 49 institutions form the SeroNet consortium to study individuals with cancer, autoimmune disease, inflammatory bowel diseases, cardiovascular diseases, human immunodeficiency virus, transplant recipients, as well as otherwise healthy pregnant women, children, college students, and high-risk occupational workers (including healthcare workers and first responders).ResultsSeveral studies focus on underrepresented populations, including ethnic minorities and rural communities. To support integrative data analyses across SeroNet studies, efforts are underway to define common data elements for standardized serology measurements, cellular and molecular assays, self-reported data, treatment, and clinical outcomes.ConclusionsIn this paper, we discuss the overarching framework for SeroNet epidemiology studies, critical research questions under investigation, and data accessibility for the worldwide scientific community. Lessons learned will help inform preparedness and responsiveness to future emerging diseases.

The objective of this study was to provide initial validity evidence for responses to the newly expanded version of the I COPPE Actions scale from adults with obesity under an exploratory latent variable approach. Longitudinal data from the 2018 Fun For Wellness Effectiveness Trial (ClinicalTrials.gov, identifier: NCT03194854) were reanalyzed in the current study. The a priori measurement theory specified a six-dimensional correlated structure of well-being actions to govern responses to the I COPPE Actions scale: "I"nterpersonal, "O"ccupational, "C"ommunity, "P"hysical, "P"sychological, and "E"conomic. The a priori measurement model exhibited exact fit to well-being actions data at baseline within an exploratory latent variable approach. There was strong evidence for at least partial measurement invariance by time for responses to the scale. Convergent (or divergent) correlations between concordant (or discordant) pairs of well-being actions self-efficacy scores and latent well-being action factors provided strong evidence for hypothesized relationships to other theoretically relevant variables.

The objective of this study was to provide initial validity evidence for responses to the newly developed Well-Being Actions Self-Efficacy (WBASE) scale from adults with obesity under an exploratory latent variable approach. Longitudinal data (N[subscript baseline] = 667 and N[subscript 30 days post-baseline] = 550) from the Well-Being and Physical Activity study (ClinicalTrials.gov, identifier: NCT03194854), which deployed the Fun For Wellness (FFW) intervention, were analyzed. The a priori measurement model exhibited close fit to baseline data within an exploratory framework. Similarly, there was strong evidence for at least partial temporal measurement invariance for the a priori WBASE scale measurement model. Convergent (and divergent) correlations between concordant (and discordant) pairs of well-being actions scores at baseline and latent well-being actions self-efficacy factors at 30 days post-baseline were observed. There was mixed evidence for the effectiveness of the FFW intervention to exert a direct effect on latent well-being actions self-efficacy at 30 days post-baseline.

In physical education and exercise science, it is common to examine mean differences between groups or to assess change across time. However, before group differences or change can be confidently examined, measurement invariance can be tested. Measurement invariance tests the equivalence of a construct across groups or across time. If measurement invariance is supported, then differences in latent means can more confidently be attributed to individuals' different standings on a construct. Though an important first step to confidently examine group differences and change across time, this technique is sometimes not used in the field. Thus, the purpose of this manuscript was to provide a didactic review and illustration of measurement invariance within the field. We review a methodological approach to measurement invariance, the sequential steps used in this approach, assessing model-data fit, and testing partial invariance. We provide an illustration of the technique and conclude with practical considerations.

Physical activity (PA) promotion is an ideal intervention target for public health because it has the potential to help individuals feel better, sleep better, and perform daily tasks more easily, in addition to providing disease prevention benefits. There is strong evidence that individual-level theory-based behavioral interventions are effective for increasing PA in adult populations but causal inference for potential specific pathways by which (i.e. how) these interventions exert total effects (i.e. direct and indirect) is often unclearly articulated – though frequently attempted to be estimated. Thus, the three objectives of this tutorial were to demonstrate (a) common cause confounding assumptions required for identification of direct and indirect causal effects; (b) how to estimate identified direct and indirect causal effects of an individual-level theory-based PA-promoting intervention; (c) how to perform sensitivity to violation of common cause confounding assumption(s) analyses. The demonstration was based on the Well-Being and Physical Activity study (ClinicalTrials.gov, identifier: NCT03194854). [ABSTRACT FROM AUTHOR]

Background: The purported benefits of online physical activity interventions, in terms of reduced costs, high reach, and easy access, may not be fully realized if participants do not engage with the programs. However, there is a lack of research on modifiable predictors (e.g., beliefs) of engagement with online physical activity interventions. The objective of this brief report was to investigate if self-efficacy to engage at baseline predicted subsequent engagement behavior in an online physical activity intervention at post-baseline. Methods: Data (N = 331) from the 2018 Fun For Wellness effectiveness trial (ClinicalTrials.gov, identifier: NCT03194854) were analyzed in this brief report. Multiple logistic regressionwas fit inMplus 8 using maximum-likelihood estimation. Results: There was evidence that self-efficacy to engage beliefs at baseline positively predicted subsequent engagement behavior in the Fun For Wellness intervention at 30 days post-baseline. Conclusions: Some recommendations to increase self-efficacy to engage in future online physical activity intervention studies were provided consistent with self-efficacy theory. [ABSTRACT FROM AUTHOR]

Physical activity promotion is a best buy for public health because it has the potential to help individuals feel better, sleep better, and perform daily tasks more easily, in addition to providing disease prevention benefits. There is strong evidence that individual-level theory-based behavioral interventions are effective for increasing physical activity levels in adult populations but causal inference from these interventions often is unclearly articulated. A directed acyclic graph (DAG) can be, but rarely is, used to determine if the causal effect of an individual-level theory-based physical activity-promoting intervention is identifiable (e.g. stripped of any spurious association). The primary objective of the current study was to demonstrate how a DAG can be used to determine if the total causal effect of an individual randomized physical activity-promoting intervention is identifiable. The demonstration was based on the Well-Being and Physical Activity study (ClinicalTrials.gov, identifier: NCT03194854). Annotated files from DAGitty and Mplus are provided. [ABSTRACT FROM AUTHOR]

Background: Sedentary behaviors, including screen-based activities, are associated with obesity, cardiovascular, and mental health risks. In the US, minority and socioeconomically disadvantaged youth engage in substantial sedentariness, requiring targeted interventions. Familias Unidas for Health and Wellness (FUHW) is a family intervention to reduce risks among Hispanic youth with overweight and obesity. Analyses examined (1) FUHW's impact on parent and adolescent screen-based sedentary behavior and (2) differential intervention effects by adolescent gender, internalizing symptoms, and body mass index. Methods: A total of 280 overweight/obese Hispanic middle schoolers and parents were randomized to FUHW or control and assessed at baseline, 6, 12, and 24 months between 2015 and 2019. Results: Linear growth models showed that exposure to FUHW was not associated with parent sedentary behavior over time (b = −0.11, P =.32) but was associated with decreases in adolescent sedentary behavior (b = −0.27, P =.03). Neither gender nor internalizing symptoms moderated intervention effects, but there were differential effects by body mass index. Compared to controls, FUHW showed significant decreases in sedentary behavior among overweight (b = −0.85, P <.01) and obese (b = −0.79, P <.01) youth but not severely obese youth. Conclusions: FUHW reduced youth screen-based sedentary behavior. Youth with severe obesity require additional intervention. [ABSTRACT FROM AUTHOR]

BackgroundInsufficient physical activity in the adult population is a global pandemic. Fun for Wellness (FFW) is a self-efficacy theory- and Web-based behavioral intervention developed to promote growth in well-being and physical activity by providing capability-enhancing opportunities to participants. ObjectiveThis study aimed to evaluate the effectiveness of FFW to increase physical activity in adults with obesity in the United States in a relatively uncontrolled setting. MethodsThis was a large-scale, prospective, double-blind, parallel-group randomized controlled trial. Participants were recruited through an online panel recruitment company. Adults with overweight were also eligible to participate, consistent with many physical activity–promoting interventions for adults with obesity. Also consistent with much of the relevant literature the intended population as simply adults with obesity. Eligible participants were randomly assigned to the intervention (ie, FFW) or the usual care (ie, UC) group via software code that was written to accomplish equal allocations to the FFW and UC groups. Data collection was Web based, fully automated, and occurred at three time points: baseline, 30 days after baseline (T2), and 60 days after baseline (T3). Participants (N=461) who were assigned to the FFW group (nFFW=219) were provided with 30 days of 24-hour access to the Web-based intervention. A path model was fit to the data consistent with the FFW conceptual model for the promotion of physical activity. ResultsThere was evidence for a positive direct effect of FFW on transport-related physical activity self-efficacy (beta=.22, P=.02; d=0.23), domestic-related physical activity self-efficacy (beta=.22, P=.03; d=0.22), and self-efficacy to regulate physical activity (beta=.16, P=.01; d=0.25) at T2. Furthermore, there was evidence for a positive indirect effect of FFW on physical activity at T3 through self-efficacy to regulate physical activity at T2 (beta=.42, 95% CI 0.06 to 1.14). Finally, there was evidence for a null direct effect of FFW on physical activity (beta=1.04, P=.47; d=0.07) at T3. ConclusionsThis study provides some initial evidence for both the effectiveness (eg, a positive indirect effect of FFW on physical activity through self-efficacy to regulate physical activity) and the ineffectiveness (eg, a null direct effect of FFW on physical activity) of the FFW Web-based behavioral intervention to increase physical activity in adults with obesity in the United States. More broadly, FFW is a scalable Web-based behavioral intervention that may effectively, although indirectly, promote physical activity in adults with obesity and therefore may be useful in responding to the global pandemic of insufficient physical activity in this at-risk population. Self-efficacy to regulate physical activity appears to be a mechanism by which FFW may indirectly promote physical activity in adults with obesity. Trial RegistrationClinicalTrials.gov NCT03194854; https://clinicaltrials.gov/ct2/show/NCT03194854.

The objective of this study was to improve the measurement of physical activity self-efficacy (PASE) in adults with obesity. To accomplish this objective, a latent variable approach was used to explore dimensionality, temporal invariance, and external validity of responses to a newly developed battery of PASE scales. Data (Nbaseline = 461 and N30 days postbaseline = 427) from the Well-Being and Physical Activity Study (ClinicalTrials.gov, identifier: NCT03194854), which deployed the Fun For Wellness intervention, were analyzed. A two-dimensional factor structure explained responses to each PASE scale at baseline. There was strong evidence for at least partial temporal measurement invariance for this two-dimensional structure in each PASE scale. There was mixed evidence that the effectiveness of the Fun For Wellness intervention exerted a direct effect on latent PASE in adults with obesity at 30 days postbaseline (i.e., external validity) of this two-dimensional structure. [ABSTRACT FROM AUTHOR]

The purpose of this study was to explore the validity of evidence for self-efficacy to regulate physical activity scale (SERPA) measurement using an exploratory latent variable approach. The objectives were to explore the dimensionality, temporal invariance, and external validity of scores produced by the SERPA, a modified version of the barriers self-efficacy scale. Data (Nbaseline= 461 and N30 days post-baseline = 427) from the Well-Being and Physical Activity Study (ClinicalTrials.gov, identifier: NCT03194854), which deployed the Fun For Wellness intervention, were analyzed. A two-dimensional factor structure explained responses to the SERPA at baseline. There was evidence for at least partial strict temporal measurement invariance for this two-dimensional structure. There was evidence for external validity of the SERPA measurement as evidenced by group assignment (i.e. the intervention) exerting a direct effect on the proposed two-dimensional structure of latent self-efficacy to regulate physical activity in adults with obesity at 30 days post-baseline. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the effectiveness of the Fun For Wellness (FFW) online intervention to increase well-being actions in adults with obesity in the United States in relatively uncontrolled settings. The FFW intervention is guided by self-efficacy theory. The study design was a large-scale, prospective, double-blind, and parallel-group randomized controlled trial. Data collection occurred at baseline, 30 days after baseline, and 60 days after baseline. Participants (N = 667) who were assigned to the FFW group (nFFW = 331) were provided with 30 days of 24-hr access to FFW. Supportive evidence was provided for the effectiveness of FFW in real-world settings to promote, either directly or indirectly, three dimensions of well-being actions: community, occupational, and psychological. This study shows that theory-based intervention may be effective in promoting well-being actions in adults with obesity in the United States. [ABSTRACT FROM AUTHOR]

The primary purpose of this tutorial is to succinctly review some options for, and consequences of, centering Level 1 predictors in commonly applied cross-sectional two-level models. It is geared toward both practitioners and researchers. A general understanding of multilevel modeling is necessary prior to understanding the subtleties of centering decisions. A review of some high-quality journals within the broad discipline of exercise science provides evidence that multilevel modeling is used relatively infrequently in this field. Therefore, a secondary purpose is to introduce "Measurement in Physical Education and Exercise Science" readers to some core facets of multilevel modeling within the framework of this tutorial. A relevant dataset is used to demonstrate potential consequences of different centering decisions within a multilevel model. Depending on the model and the data, different centering decisions can exert non-trivial influence on the meaning of some model parameters, results from fitting the model, and subsequent conclusions. (Contains 3 tables and 1 figure.)

To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1545-5300.2010.01337.x Byline: AHNALEE M. BRINCKS (*), DANIEL J. FEASTER (*), VICTORIA B. MITRANI ([dagger]) Keywords: Stress; Coping; HIV; Family; Multilevel Mediation Abstract: All abstracts are available in Spanish and Mandarin Chinese on Wiley Online Library (http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1545-5300). Please pass this information on to your international colleagues and students. Families are influential systems and may be an important context in which to consider the stress and coping process. To date, many studies have focused on modeling the stress and coping process for the individual, isolated from the family. The purpose of this secondary analysis was to investigate a cross-sectional stress and coping model for HIV-positive African-American mothers recruited from HIV service facilities in South Florida (n=214) and their family members (n=294). Avoidance coping was hypothesized to mediate the relationship between stress and psychological distress. In addition, the family average of individual stress was hypothesized to moderate the relationship between avoidance coping and psychological distress. For all constructs, individuals reported on themselves and multilevel modeling techniques were used to account for similarities between members of the same family. The estimated mediation effect was significant. Aggregated family stress significantly moderated the relationship between avoidance coping and psychological distress. This study suggests that individuals exhibit different relationships between avoidance coping and psychological outcomes and that average stress reported by members of a family moderates the relationship between avoidance coping and psychological distress. Abstract (French) RESUMEN Las familias son sistemas influyentes y pueden ser un contexto importante en el cual considerar el estres y el proceso de afrontamiento. Hasta la fecha, muchos estudios se han centrado en modelar el estres y el proceso de afrontamiento para el individuo, aislado de la familia. El proposito de este analisis secundario fue investigar un modelo transversal de estres y afrontamiento para madres afroamericanas con VIH positivo convocadas en centros de salud especializados en VIH de South Florida (n=214) y sus familiares (n=294). Se planteo la hipotesis de afrontamiento evasivo para mediar la relacion entre estres y angustia psicologica. Tambien se planteo la hipotesis del promedio familiar de estres individual para moderar la relacion entre afrontamiento evasivo y angustia psicologica. Para todos los constructos, las personas informaron sobre si mismas y se utilizaron tecnicas de modelo multinivel para explicar las similitudes entre miembros de la misma familia. El efecto estimado de mediacion fue importante. El estres familiar en conjunto modero considerablemente la relacion entre el afrontamiento evasivo y la angustia psicologica. Este estudio sugiere que las personas muestran relaciones diferentes entre el afrontamiento evasivo y los resultados psicologicos, y que el estres promedio informado por los miembros de la familia modera la relacion entre el afrontamiento evasivo y la angustia psicologica. Palabras clave: estres, afrontamiento, VIH, familia, mediacion multinivel Author Affiliation: (*)Leonard M. Miller School of Medicine, Epidemiology & Public Health, University of Miami, Miami, FL. ([dagger])Center of Excellence for Health Disparities Research, El Centro, School of Nursing and Health Studies, University of Miami, Miami, FL. Article note: Correspondence concerning this article should be addressed to Ahnalee M. Brincks, Leonard M. Miller School of Medicine, Epidemiology & Public Health, University of Miami, 1425 NW 10 Ave., Miami, FL 33136. E-mail: Abrincks@med.miami.edu

AbstractMeasuring sexual orientation involves assessing multiple domains to account for the various conceptualizations adolescents may have. The purpose of this study was to examine: (1) the factor structure and reliability of the Klein Sexual Orientation Grid (KSOG) and (2) measurement invariance across age and nativity groups. Participants included 454 Latina/o/x adolescents [25.3% Latina/o/x sexual minority youth (LSMY) and 74.7% Latina/o/x non-SMY]. We examined the hypothesized factor structure of the KSOG using confirmatory factor analysis and the configural, metric, and scalar invariance of the identified factor structure was examined between age (12–14 and 15–17) and nativity (U.S. born and foreign-born) groups. A single factor captured: identity, attraction, emotional connection, and fantasies (CFI/RMSEA = 1.00/.000). We found evidence for metric noninvariance suggesting that sexual orientation as a latent construct does not perform equivalently among Hispanic adolescents who are younger versus older (Δχ2(3) = 106.01, p < 0.001, ΔCFI = 0.041, ΔTLI = 0.064, and ΔRMSEA = 0.154) or adolescents who are U.S. born versus foreign-born (Δχ2(3) = 10.34, p < 0.05, ΔCFI = 0.003, ΔTLI = 0.002, and ΔRMSEA = 0.011). The KSOG may not be used equivalently among older and younger Latina/o/x adolescents and Latina/o/x adolescents who are U.S. born and foreign-born. [ABSTRACT FROM AUTHOR]

Hierarchical data are becoming increasingly complex, often involving more than two levels. Centering decisions in multilevel models are closely tied to substantive hypotheses and require researchers to be clear and cautious about their choices. This study investigated the implications of group mean centering (i.e., centering within context; CWC) and grand mean centering (CGM) of predictor variables in three-level contextual models. The goals were to (a) determine equivalencies in the means and variances across the centering options and (b) use the algebraic relationships between the centering choices to clarify the interpretation of the estimated parameters. We provide recommendations to assist the researcher in making centering decisions for analysis of three-level contextual models [ABSTRACT FROM PUBLISHER]

Purpose: Limiting time with friends (LTWF), a facet of parental monitoring, may be protective for newly incident adolescent alcohol, tobacco cigarette, and cannabis use., Methods: We extended epidemiological evidence based on estimates from nationally representative samples of US adolescents aged 12-17 years, across 18 years of independent samples of the National Survey on Drug Use and Health (2002-2019). We estimated the prevalence of always LTWF, and odds ratios examining incident alcohol, tobacco cigarette, and cannabis use by LTWF within age and cohort., Results: The prevalence of always LTWF decreased with older age within study year and cohort. The odds of alcohol initiation were lower among youth reporting their parents were always LTWF. The odds of tobacco cigarette and cannabis initiation were lower among younger youth reporting their parents were always LTWF., Discussion: Future research is needed to fully understand the influence of LTWF on incident substance use, particularly for older adolescents., (Copyright © 2024 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)