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12 results on '"Brill, Silke"'

5. Microcarrier-based expansion of adipose tissue and bone marrow derived human mesenchymal stem cells in therapeutically relevant doses

Author

Jossen, Valentin, Ott, Anita, Kaiser, Stephan, Brill, Silke, Spicker, Sonja, Safavi-nab, Agnieszka, Jüngerkes, Frank, Siehoff, Ann, Rosenbaum, Claudia, Reinisch, Barbara, van den Bos, Christian, Eibl, Dieter, Eibl-Schindler, Regine, Jossen, Valentin, Ott, Anita, Kaiser, Stephan, Brill, Silke, Spicker, Sonja, Safavi-nab, Agnieszka, Jüngerkes, Frank, Siehoff, Ann, Rosenbaum, Claudia, Reinisch, Barbara, van den Bos, Christian, Eibl, Dieter, and Eibl-Schindler, Regine

Published
2021

6. Fluid flow and cell proliferation of mesenchymal adipose-derived stem cells in small-scale, stirred, single-use bioreactors

Author

Kaiser, Stephan, Jossen, Valentin, Schirmaier, Carmen, Eibl, Dieter, Brill, Silke, van den Bos, Christian, Eibl-Schindler, Regine, Kaiser, Stephan, Jossen, Valentin, Schirmaier, Carmen, Eibl, Dieter, Brill, Silke, van den Bos, Christian, and Eibl-Schindler, Regine

Abstract

The fluid flow and suspension characteristics inside small-scale, stirred, single-use bioreactors were investigated experimentally and by means of computational fluid dynamics. The required impeller speeds for homogenous suspension were determined for two microcarrier types. The shear stress level and turbulence distribution were predicted using a numerical model, which was verified by particle image velocimetry measurements. In subsequent cultivations of primary mesenchymal adipose-derived stem cells, up to 31.4-fold expansion in cell number was achieved for serum concentrations as low as 5 %.

Published
2018

12. Fluid Flow and Cell Proliferation of Mesenchymal Adipose-Derived Stem Cells in Small-Scale, Stirred, Single-Use Bioreactors.

Author

Kaiser, Stephan, Jossen, Valentin, Schirmaier, Carmen, Eibl, Dieter, Brill, Silke, van den Bos, Christian, and Eibl, Regine

Abstract

The fluid flow and suspension characteristics inside small-scale, stirred, single-use bioreactors were investigated experimentally and by means of computational fluid dynamics. The required impeller speeds for homogenous suspension were determined for two microcarrier types. The shear stress level and turbulence distribution were predicted using a numerical model, which was verified by particle image velocimetry measurements. In subsequent cultivations of primary mesencymal adipose-derived stem cells, up to 31.4-fold expansion in cell number was achieved for serum concentrations as low as 5 %. [ABSTRACT FROM AUTHOR]

Published
2013
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