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168 results on '"Brignardello, E"'

2. Optimal Delivery of Follow-Up Care After Allogeneic Hematopoietic Stem-Cell Transplant: Improving Patient Outcomes with a Multidisciplinary Approach

Author

Giaccone L, Felicetti F, Butera S, Faraci D, Cerrano M, Dionisi Vici M, Brunello L, Fortunati N, Brignardello E, and Bruno B

Subjects
ltfu, allografting, complications, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Luisa Giaccone,1,2 Francesco Felicetti,3 Sara Butera,1,2 Danilo Faraci,1,2 Marco Cerrano,1,2 Margherita Dionisi Vici,3 Lucia Brunello,1,2 Nicoletta Fortunati,3 Enrico Brignardello,3,* Benedetto Bruno1,2,* 1Division of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy; 2Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, University of Torino, Torino, Italy; 3Transition Unit for Childhood Cancer Survivors, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy*These authors contributed equally to this workCorrespondence: Luisa GiacconeDivision of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Via Genova 3, Torino 10126, ItalyTel +39 011-6334354Fax +39 011-6963737Email luisa.giaccone@unito.itAbstract: The increasing indications for allogeneic stem-cell transplant in patients with hematologic malignancies and non-malignant diseases combined with improved clinical outcomes have contributed to increase the number of long-term survivors. However, survivors are at increased risk of developing a unique set of complications and late effects, besides graft-versus-host disease and disease relapse. In this setting, the management capacity of a single health-care provider can easily be overwhelmed. Thus, to provide appropriate survivorship care, a multidisciplinary approach for the long-term follow-up is essential. This review aims at summarizing the most relevant information that a health-care provider should know to establish a follow-up care plan, in the light of individual exposures and risk factors, that includes all organ systems and considers the psychological burden of these patients.Keywords: long-term, complications, allografting

Published
2020

9. AISF position paper on HCV in immunocompromised patients

Author

Angelucci, E, Astegiano, M, Baratelli, C, Biancone, L, Bironzo, P, Brancaccio, G, Brunetto, M, Bruno, R, Burra, P, Cabras, M, l Caraceni, P, Chialà, C, Clemente, M, Colli, A, Daniele, B, De Gasperi, E, Di Marco, V, Ditto, M, Fagiuoli, S, Ferri, C, Gaeta, G, Grossi, P, Imperatrice, B, Lampertico, P, Macaluso, F, Madonia, S, Marignani, M, Mazzarelli, C, Mella, A, Missale, G, Parisi, S, Pasulo, L, Puoti, M, Rendina, M, Ribaldone, D, Rossi, G, Toniutto, P, Tucci, A, Vajro, P, Viganò, M, Volpes, R, Zignego, A, Giannini, E, Miele, L, Russo, F, Petta, S, Bonora, S, Brignardello, E, Busca, A, Cariti, G, Cavallo, F, Conforti, M, Coscia, M, Craxì, A, Curci, D, Cusinato, S, Di Maio, M, Valle, R, Fusaro, E, Giacardi, A, Giaccone, L, Lagget, M, Libertucci, D, Minutolo, R, Montrucchio, G, Orlando, A, Orsucci, L, Pasquina, C, Pera, A, Peroni, C, Pirisi, M, Racca, P, Riccardini, F, Rizzetto, M, Salizzoni, M, Salomone, M, Saracco, G, Scaglione, L, Torre, G, Tozzi, R, Vitolo, U, Verme, G, Brunetto, MR, Cabras, MG, Clemente, MG, Ditto, MC, Gaeta, GB, Grossi, PA, Macaluso, FS, Zignego, AL, Giannini, EG, Russo, FP, Valle, RD, Peroni, CL, Saracco, GM, Angelucci, E, Astegiano, M, Baratelli, C, Biancone, L, Bironzo, P, Brancaccio, G, Brunetto, M, Bruno, R, Burra, P, Cabras, M, l Caraceni, P, Chialà, C, Clemente, M, Colli, A, Daniele, B, De Gasperi, E, Di Marco, V, Ditto, M, Fagiuoli, S, Ferri, C, Gaeta, G, Grossi, P, Imperatrice, B, Lampertico, P, Macaluso, F, Madonia, S, Marignani, M, Mazzarelli, C, Mella, A, Missale, G, Parisi, S, Pasulo, L, Puoti, M, Rendina, M, Ribaldone, D, Rossi, G, Toniutto, P, Tucci, A, Vajro, P, Viganò, M, Volpes, R, Zignego, A, Giannini, E, Miele, L, Russo, F, Petta, S, Bonora, S, Brignardello, E, Busca, A, Cariti, G, Cavallo, F, Conforti, M, Coscia, M, Craxì, A, Curci, D, Cusinato, S, Di Maio, M, Valle, R, Fusaro, E, Giacardi, A, Giaccone, L, Lagget, M, Libertucci, D, Minutolo, R, Montrucchio, G, Orlando, A, Orsucci, L, Pasquina, C, Pera, A, Peroni, C, Pirisi, M, Racca, P, Riccardini, F, Rizzetto, M, Salizzoni, M, Salomone, M, Saracco, G, Scaglione, L, Torre, G, Tozzi, R, Vitolo, U, Verme, G, Brunetto, MR, Cabras, MG, Clemente, MG, Ditto, MC, Gaeta, GB, Grossi, PA, Macaluso, FS, Zignego, AL, Giannini, EG, Russo, FP, Valle, RD, Peroni, CL, and Saracco, GM

Abstract

This report summarizes the clinical features and the indications for treating HCV infection in immunocompromised and transplanted patients in the Direct Acting Antiviral drugs era.

Published
2019

13. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer : Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium

Author

Clement, S C, Kremer, Leontine C M, Verburg, Frederik A., Simmons, J H, Goldfarb, M, Peeters, Robin P, Alexander, E K, Bardi, Edit, Brignardello, E, Constine, Louis S, Dinauer, C A, Drozd, V M, Felicetti, F, Frey, S.E., Heinzel, Andreas, van den Heuvel-Eibrink, M M, Huang, S A, Links, Thera P, Krummel-Lorenz, B, Mulder, Renée L, Neggers, S J, Nieveen van Dijkum, E J M, Oeffinger, Kevin C, van Rijn, R., Rivkees, S A, Ronckers, Cécile M., Schneider, A B, Skinner, R., Wasserman, J D, Wynn, T, Hudson, M., Nathan, P C, van Santen, H M, Clement, S C, Kremer, Leontine C M, Verburg, Frederik A., Simmons, J H, Goldfarb, M, Peeters, Robin P, Alexander, E K, Bardi, Edit, Brignardello, E, Constine, Louis S, Dinauer, C A, Drozd, V M, Felicetti, F, Frey, S.E., Heinzel, Andreas, van den Heuvel-Eibrink, M M, Huang, S A, Links, Thera P, Krummel-Lorenz, B, Mulder, Renée L, Neggers, S J, Nieveen van Dijkum, E J M, Oeffinger, Kevin C, van Rijn, R., Rivkees, S A, Ronckers, Cécile M., Schneider, A B, Skinner, R., Wasserman, J D, Wynn, T, Hudson, M., Nathan, P C, and van Santen, H M

Published
2018

14. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium

Author

Endocrinologie onderzoek, Zorg en O&O, PMC Medisch specialisten, Onderzoeksgroep 7, Brain, Endocrinologie patientenzorg, Child Health, Clement, S C, Kremer, Leontine C M, Verburg, Frederik A., Simmons, J H, Goldfarb, M, Peeters, Robin P, Alexander, E K, Bardi, Edit, Brignardello, E, Constine, Louis S, Dinauer, C A, Drozd, V M, Felicetti, F, Frey, S.E., Heinzel, Andreas, van den Heuvel-Eibrink, M M, Huang, S A, Links, Thera P, Krummel-Lorenz, B, Mulder, Renée L, Neggers, S J, Nieveen van Dijkum, E J M, Oeffinger, Kevin C, van Rijn, R., Rivkees, S A, Ronckers, Cécile M., Schneider, A B, Skinner, R., Wasserman, J D, Wynn, T, Hudson, M., Nathan, P C, van Santen, H M, Endocrinologie onderzoek, Zorg en O&O, PMC Medisch specialisten, Onderzoeksgroep 7, Brain, Endocrinologie patientenzorg, Child Health, Clement, S C, Kremer, Leontine C M, Verburg, Frederik A., Simmons, J H, Goldfarb, M, Peeters, Robin P, Alexander, E K, Bardi, Edit, Brignardello, E, Constine, Louis S, Dinauer, C A, Drozd, V M, Felicetti, F, Frey, S.E., Heinzel, Andreas, van den Heuvel-Eibrink, M M, Huang, S A, Links, Thera P, Krummel-Lorenz, B, Mulder, Renée L, Neggers, S J, Nieveen van Dijkum, E J M, Oeffinger, Kevin C, van Rijn, R., Rivkees, S A, Ronckers, Cécile M., Schneider, A B, Skinner, R., Wasserman, J D, Wynn, T, Hudson, M., Nathan, P C, and van Santen, H M

Published
2018

16. Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium

Author

Clement, S.C., primary, Kremer, L.C.M., additional, Verburg, F.A., additional, Simmons, J.H., additional, Goldfarb, M., additional, Peeters, R.P., additional, Alexander, E.K., additional, Bardi, E., additional, Brignardello, E., additional, Constine, L.S., additional, Dinauer, C.A., additional, Drozd, V.M., additional, Felicetti, F., additional, Frey, E., additional, Heinzel, A., additional, van den Heuvel-Eibrink, M.M., additional, Huang, S.A., additional, Links, T.P., additional, Lorenz, K., additional, Mulder, R.L., additional, Neggers, S.J., additional, Nieveen van Dijkum, E.J.M., additional, Oeffinger, K.C., additional, van Rijn, R.R., additional, Rivkees, S.A., additional, Ronckers, C.M., additional, Schneider, A.B., additional, Skinner, R., additional, Wasserman, J.D., additional, Wynn, T., additional, Hudson, M.M., additional, Nathan, P.C., additional, and van Santen, H.M., additional

Published
2018
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17. Activation of Palliative Cares by hospital oncologists: first results of a survey conducted by Rete Oncologica del Piemonte e della Valle d'Aosta

Author

Alabiso, I., primary, Ballari, A., additional, Brignardello, E., additional, Numico, G., additional, Sperti, E., additional, Cristofano, A., additional, Russi, E., additional, Oliva, C., additional, Mistrangelo, M., additional, Levis, M., additional, Gallo, M., additional, Di Costanzo, G., additional, and Bertetto, O., additional

Published
2016
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29. Dihydrotestosterone affects the growth of hormone-unresponsive breast cancer cells: an indirect action

Author

Di Monaco, M., Leonardi, L., Gatto, V., Marco Gallo, Brignardello, E., and Boccuzzi, G.

Subjects
Neoplasms, Hormone-Dependent, Antineoplastic Agents, Hormonal, Carcinoma, Ductal, Breast, Androgen Antagonists, Breast Neoplasms, Dihydrotestosterone, Estrogens, Adenocarcinoma, Flutamide, Growth Inhibitors, Neoplasm Proteins, Receptors, Androgen, Culture Media, Conditioned, Androgens, Humans, Female, Cell Division, Progesterone
Abstract

Cell to cell interaction, which plays a crucial role in breast cancer growth, may be regulated by steroid hormones. This study examined dihydrotestosterone (DHT) effects on the interaction between the steroid receptor positive MCF-7 and the steroid receptor negative MDA-MB-231 breast cancer cell lines. The growth of MDA-MB-231 cells was inhibited by medium conditioned by MCF-7 cells grown in presence of DHT but not by medium conditioned by MCF-7 cells grown in presence of both DHT and the antiandrogen hydroxyflutamide. Trypsin pretreatment of conditioned medium abolished its growth-inhibitory effect on hormone-unresponsive cells. DHT itself did not affect the growth of MDA-MB-231 cells when directly added to their culture medium. Data suggest that DHT stimulates, via the androgen receptor, the androgen-responsive breast cancer cells to produce a peptide factor(s) capable of inhibiting the growth of hormone-unresponsive cells.

Published
1995

30. Dehydroepiandrosterone antiestrogenic action through androgen receptor in MCF-7 human breast cancer cell line

Author

Boccuzzi, Giuseppe, DI BOCCUZZI, G., DI MONACO, M., Brignardello, E., Leonardi, L., Gatto, V., Pizzini, A., and Gallo, M.

Subjects
Estradiol, Estrogen Antagonists, Breast Neoplasms, Dehydroepiandrosterone, Glucosephosphate Dehydrogenase, Flutamide, Kinetics, Tamoxifen, Receptors, Androgen, Tumor Cells, Cultured, Humans, Female, Diethylstilbestrol, Cell Division
Abstract

The possible mechanisms of the inhibitory effect of Dehydroepiandrosterone (DHEA) on the estrogen-induced growth of MCF-7 human breast cancer cells were explored. The impairment of metabolic pathways, via the inhibition of glucose-6-phosphate dehydrogenase (G6PD) activity, was excluded: G6PD activity in MCF-7 homogenate was reduced by DHEA only at a very high concentration (50 microM), while no inhibitory action on the enzyme activity was detected when DHEA was added at the antimitotic concentrations (0.02-0.5 microM). A steroid receptor mediated effect was explored: DHEA might either activate androgen receptors (AR) or partially displace E2 from estrogen receptor (ER). The pure antiandrogens Flutamide and Hydroxyflutamide reversed the inhibitory effect of DHEA on MCF-7 cell growth, whereas both the nonsteroidal estrogen Diethylstilbestrol and the antiestrogen Tamoxifen were ineffective. Results demonstrate that the AR activation plays a pivotal role in the inhibitory action of DHEA on the E2-induced MCF-7 growth.

Published
1993

31. Opposite effects of dehydroepiandrosterone on the growth of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas

Author

Boccuzzi G, Aragno M, Brignardello E, Tamagno E, Conti G, Di Monaco M, Silvia Anna RACCA, Danni O, and Di Carlo F

Subjects
Rats, Sprague-Dawley, Estradiol, Receptors, Estrogen, 9,10-Dimethyl-1,2-benzanthracene, Ovariectomy, Animals, Mammary Neoplasms, Experimental, Female, Dehydroepiandrosterone, Cell Division, Rats
Abstract

The effect of dehydroepiandrosterone (DHEA) (2 mg, twice daily p.o.) on the growth of the dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma was studied in intact and ovariectomized adult female rats. DHEA treatment stimulated the tumor growth in ovariectomized animals. Conversely, the tumors of intact rats treated with DHEA progressed to a lesser extent than those of intact untreated animals (p0.01). Plasma levels of DHEA were higher in DHEA-fed than in untreated animals (p.01), whereas E2 concentrations were unchanged after DHEA administration. Estrogen receptor (ER) concentrations in tumor tissue of ovariectomized animals given DHEA were no different form those found in intact rats, whereas ER were undetectable in untreated ovariectomized rats. The data indicate that DHEA stimulates the growth of DMBA-induced mammary tumors in ovariectomized rats, while it reduces the tumor progression in intact animals.

Published
1992

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