795 results on '"Bright, S."'
Search Results
2. A review of preclinical evidence of Cryptolepis nigrescens (Wennberg) L. Joubert. and Bruyns., Prosopsis africana (Guill. and Perr.) Taub. and Pterygota macrocarpa K. Schum. traditionally used to manage tumours in Ghana
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Afolayan, Oluwatomisin D., Firempong, Caleb K., Komlaga, Gustav, Addo-Fordjour, Patrick, Addy, Bright S., and Emikpe, Benjamin O.
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- 2024
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3. Star Cluster Catalogs for the LEGUS Dwarf Galaxies
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Cook, D. O., Lee, J. C., Adamo, A., Kim, H., Chandar, R., Whitmore, B. C., Mok, A., Ryon, J. E., Dale, D. A., Calzetti, D., Andrews, J. E., Aloisi, A., Ashworth, G., Bright, S. N., Brown, T. M., Christian, C., Cignoni, M., Clayton, G. C., da Silva, R., de Mink, S. E., Dobbs, C. L., Elmegreen, B. G., Elmegreen, D. M., Evans, A. S., Fumagalli, M., Gallagher III, J. S., Gouliermis, D. A., Grasha, K., Grebel, E. K., Herrero, A., Hunter, D. A., Jensen, E. I., Johnson, K. E., Kahre, L., Kennicutt, R. C., Krumholz, M. R., Lee, N. J., Lennon, D., Linden, S., Martin, C., Messa, M., Nair, P., Nota, A., Ostlin, G., Parziale, R. C., Pellerin, A., Regan, M. W., Sabbi, E., Sacchi, E., Schaerer, D., Schiminovich, D., Shabani, F., Slane, F. A., Small, J., Smith, C. L., Smith, L. J., Taibi, S., Thilker, D. A., de la Torre, I. C., Tosi, M., Turner, J. A., Ubeda, L., Van Dyk, S. D., Walterbos, R. A. M., and Wofford, A.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the star cluster catalogs for 17 dwarf and irregular galaxies in the $HST$ Treasury Program "Legacy ExtraGalactic UV Survey" (LEGUS). Cluster identification and photometry in this subsample are similar to that of the entire LEGUS sample, but special methods were developed to provide robust catalogs with accurate fluxes due to low cluster statistics. The colors and ages are largely consistent for two widely used aperture corrections, but a significant fraction of the clusters are more compact than the average training cluster. However, the ensemble luminosity, mass, and age distributions are consistent suggesting that the systematics between the two methods are less than the random errors. When compared with the clusters from previous dwarf galaxy samples, we find that the LEGUS catalogs are more complete and provide more accurate total fluxes. Combining all clusters into a composite dwarf galaxy, we find that the luminosity and mass functions can be described by a power law with the canonical index of $-2$ independent of age and global SFR binning. The age distribution declines as a power law, with an index of $\approx-0.80\pm0.15$, independent of cluster mass and global SFR binning. This decline of clusters is dominated by cluster disruption since the combined star formation histories and integrated-light SFRs are both approximately constant over the last few hundred Myr. Finally, we find little evidence for an upper-mass cutoff ($<2\sigma$) in the composite cluster mass function, and can rule out a truncation mass below $\approx10^{4.5}$M$_{\odot}$ but cannot rule out the existence of a truncation at higher masses., Comment: 25 pages; 28 figures (Accepted to MNRAS)
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- 2019
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4. Modeling the effect of soil fertility management options on maize yield stability under variable climate in a sub-humid zone in Ghana
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Dilys S. MacCarthy, Noah Adamtey, Bright S. Freduah, Benedicta Y. Fosu-Mensah, Godfred K. Ofosu-Budu, and Andreas Fliessbach
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local organic resources ,yield uncertainty ,integrated nutrient management ,West Africa ,resource use efficiency ,climate variability ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
IntroductionUncertainty in the yield of maize due to variability in weather is a major challenge to smallholder farmers in Sub Sahara Africa. This study explores the potential of combining locally available organic resources and inorganic fertilizer to increase grain yield and reduce variability in yields associated with variations in rainfall distribution.MethodsTo assess the effectiveness of this practice, the Agricultural Production Systems sIMulator (APSIM) crop model was calibrated and evaluated using maize experiments on nutrient management options. The evaluated model was used to simulate maize growth and yield using multiple-year data (1984–2018) under different planting windows for two growing seasons. The treatments were (i) control, (ii) inorganic fertilizer alone (INOFRecom), combining organic resources [empty fruit bunch of palm (EFB) and compost with inorganic fertilizer (INOF) to make up equivalent nutrients in (ii)]; (iii) EFB + INOF and (iv) Comp + INOF.ResultsThough all the soil amendments boosted grain output, the EFB + INOF treatment outperformed the other treatments in the major season with gains of between 161 and 211% and the most stable (least inter-annual variability of 27%) yield. Across the planting windows, the INOFRecom and EFB + INOF treatments achieved comparable yield increments in the minor season. Though grain yield variability was high during the minor rainy season, combining organic and inorganic fertilizers reduced inter-annual yield variability, thus, lowering uncertainty in yield due to variable inter-annual rainfall. Combining local organic resources with a reduced amount of inorganic fertilizer produced higher yields and better yield stability compared to using only inorganic fertilizer.DiscussionsThus, such soil fertility management solutions might sustain resource use and boost maize grain yield in the study area, where strategies for sustainable crop nutrition remain a critical necessity. The improved nitrogen management regimes may result in fewer environmental hazards for vulnerable rainfed agricultural systems.
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- 2023
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5. Extinction Maps and Dust-to-Gas Ratios in Nearby Galaxies with LEGUS
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Kahre, L., Walterbos, R. A., Kim, H., Thilker, D., Calzetti, D., Lee, J. C., Sabbi, E., Ubeda, L., Aloisi, A., Cignoni, M., Cook, D. O., Dale, D. A., Elmegreen, B. G., Elmegreen, D. M., Fumagalli, M., Gallagher III, J. S., Gouliermis, D. A., Grasha, K., Grebel, E. K., Hunter, D. A., Sacchi, E., Smith, L. J., Tosi, M., Adamo, A., Andrews, J. E., Ashworth, G., Bright, S. N., Brown, T. M., Chandar, R., Christian, C., de Mink, S. E., Dobbs, C., Evans, A. S., Herrero, A., Johnson, K. E., Kennicutt, R. C., Krumholz, M. R., Messa, M., Nair, P., Nota, A., Pellerin, A., Ryon, J. E., Schaerer, D., Shabani, F., Van Dyk, S. D., Whitmore, B. C., and Wofford, A.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present a study of the dust-to-gas ratios in five nearby galaxies NGC 628 (M74), NGC 6503, NGC 7793, UGC 5139 (Holmberg I), and UGC 4305 (Holmberg II). Using Hubble Space Telescope broad band WFC3/UVIS UV and optical images from the Treasury program LEGUS (Legacy ExtraGalactic UV Survey) combined with archival HST/ACS data, we correct thousands of individual stars for extinction across these five galaxies using an isochrone-matching (reddening-free Q) method. We generate extinction maps for each galaxy from the individual stellar extinctions using both adaptive and fixed resolution techniques, and correlate these maps with neutral HI and CO gas maps from literature, including The HI Nearby Galaxy Survey (THINGS) and the HERA CO-Line Extragalactic Survey (HERACLES). We calculate dust-to-gas ratios and investigate variations in the dust-to-gas ratio with galaxy metallicity. We find a power law relationship between dust-to-gas ratio and metallicity, consistent with other studies of dust-to-gas ratio compared to metallicity. We find a change in the relation when H$_2$ is not included. This implies that underestimation of $N_{H_2}$ in low-metallicity dwarfs from a too-low CO-to-H$_2$ conversion factor $X_{CO}$ could have produced too low a slope in the derived relationship between dust-to-gas ratio and metallicity. We also compare our extinctions to those derived from fitting the spectral energy distribution (SED) using the Bayesian Extinction and Stellar Tool (BEAST) for NGC 7793 and find systematically lower extinctions from SED-fitting as compared to isochrone matching., Comment: 22 pages, 14 figures, accepted by ApJ
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- 2018
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6. The resolved stellar populations in the LEGUS galaxies
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Sabbi, E., Calzetti, D., Ubeda, L., Adamo, A., Cignoni, M., Thilker, D., Aloisi, A., Elmegreen, B. G., Elmegreen, D. M., Gouliermis, D. A., Grebel, E. K., Messa, M., Smith, L. J., Tosi, M., Dolphin, A., Andrews, J. E., Ashworth, G., Bright, S. N., Brown, T. M., Chandar, R., Christian, C., Clayton, G. C., Cook, D. O., Dale, D. A., de Mink, S. E., Dobbs, C., Evans, A. S., Fumagalli, M., Gallagher III, J. S., Grasha, K., Herrero, A., Hunter, D. A., Johnson, K. E., Kahre, L., Kennicutt, R. C., Kim, H., Krumholz, M. R., Lee, J. C., Lennon, D., Martin, C., Nair, P., Nota, A., Ostlin, G., Pellerin, A., Prieto, J., Regan, M. W., Ryon, J. E., Sacchi, E., Schaerer, D., Schiminovich, D., Shabani, F., Van Dyk, S. D., Walterbos, R., Whitmore, B. C., and Wofford, A.
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Astrophysics - Astrophysics of Galaxies - Abstract
The Legacy ExtraGalactic UV Survey (LEGUS) is a multiwavelength Cycle 21 Treasury program on the Hubble Space Telescope. It studied 50 nearby star-forming galaxies in five bands from the near UV to the I-band, combining new Wide Field Camera 3 observations with archival Advanced Camera for Surveys data. LEGUS was designed to investigate how star formation occurs and develops on both small and large scales, and how it relates to the galactic environments. In this paper we present the photometric catalogs for all the apparently single stars identified in the 50 LEGUS galaxies. Photometric catalogs and mosaicked images for all filters are available for download. We present optical and near UV color-magnitude diagrams for all the galaxies. For each galaxy we derived the distance from the tip of the red giant branch. We then used the NUV color-magnitude diagrams to identify stars more massive than 14 Mo, and compared their number with the number of massive stars expected from the GALEX FUV luminosity. Our analysis shows that the fraction of massive stars forming in star clusters and stellar associations is about constant with the star formation rate. This lack of a relation suggests that the time scale for evaporation of unbound structures is comparable or longer than 10 Myr. At low star formation rates this translates to an excess of mass in clustered environments as compared to model predictions of cluster evolution, suggesting that a significant fraction of stars form in unbound systems., Comment: 71 pages, 15 figures, 4 tables, Accpeted for publication on ApJS
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- 2018
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7. The Young Star Cluster population of M51 with LEGUS: I. A comprehensive study of cluster formation and evolution
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Messa, M., Adamo, A., Östlin, G., Calzetti, D., Grasha, K., Grebel, E. K., Shabani, F., Chandar, R., Dale, D. A., Dobbs, C. L., Elmegreen, B. G., Fumagalli, M., Gouliermis, D. A., Kim, H., Smith, L. J., Thilker, D. A., Tosi, M., Ubeda, L., Walterbos, R., Whitmore, B. C., Fedorenko, K., Mahadevan, S., Andrews, J. E., Bright, S. N., Cook, D. O., Kahre, L., Nair, P., Pellerin, A., Ryon, J., Ahmad, S. D., Beale, L. P., Brown, K., Clarkson, D. A., Guidarelli, G. C., Parziale, R., Turner, J., and Weber, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
Recently acquired WFC3 UV (F275W and F336W) imaging mosaics under the Legacy Extragalactic UV Survey (LEGUS) combined with archival ACS data of M51 are used to study the young star cluster (YSC) population of this interacting system. Our newly extracted source catalogue contains 2834 cluster candidates, morphologically classified to be compact and uniform in colour, for which ages, masses and extinction are derived. In this first work we study the main properties of the YSC population of the whole galaxy, considering a mass-limited sample. Both luminosity and mass functions follow a power law shape with slope -2, but at high luminosities and masses a dearth of sources is observed. The analysis of the mass function suggests that it is best fitted by a Schechter function with slope -2 and a truncation mass at $1.00\pm0.12\times10^5\ M_\odot$. Through Monte Carlo simulations we confirm this result and link the shape of the luminosity function to the presence of a truncation in the mass function. A mass limited age function analysis, between 10 and 200 Myr, suggests that the cluster population is undergoing only moderate disruption. We observe little variation in the shape of the mass function at masses above $1\times10^4\ M_\odot$, over this age range. The fraction of star formation happening in the form of bound clusters in M51 is $\sim20\%$ in the age range 10 to 100 Myr and little variation is observed over the whole range from 1 to 200 Myr., Comment: 25 pages, 19 figures, 10 tables. Accepted for publication in MNRAS (14 Sep. 2017)
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- 2017
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8. Hierarchical Star Formation in Turbulent Media: Evidence from Young Star Clusters
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Grasha, K., Elmegreen, B. G., Calzetti, D., Adamo, A., Aloisi, A., Bright, S. N., Cook, D. O., Dale, D. A., Fumagalli, M., Gallagher, J. S., Gouliermis, D. A., Grebel, E. K., Kahre, L., Kim, H., Krumholz, M. R., Lee, J. C., Messa, M., Ryon, J. E., and Ubeda, L.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present an analysis of the positions and ages of young star clusters in eight local galaxies to investigate the connection between the age difference and separation of cluster pairs. We find that star clusters do not form uniformly but instead are distributed such that the age difference increases with the cluster pair separation to the 0.25-0.6 power, and that the maximum size over which star formation is physically correlated ranges from ~200 pc to ~1 kpc. The observed trends between age difference and separation suggest that cluster formation is hierarchical both in space and time: clusters that are close to each other are more similar in age than clusters born further apart. The temporal correlations between stellar aggregates have slopes that are consistent with turbulence acting as the primary driver of star formation. The velocity associated with the maximum size is proportional to the galaxy's shear, suggesting that the galactic environment influences the maximum size of the star-forming structures., Comment: 13 pages, 10 figures, accepted for publication in ApJ
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- 2017
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9. Effective Radii of Young, Massive Star Clusters in Two LEGUS Galaxies
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Ryon, J. E., Gallagher, J. S., Smith, L. J., Adamo, A., Calzetti, D., Bright, S. N., Cignoni, M., Cook, D. O., Dale, D. A., Elmegreen, B. E., Fumagalli, M., Gouliermis, D. A., Grasha, K., Grebel, E. K., Kim, H., Messa, M., Thilker, D., and Ubeda, L.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present a study of the effective (half-light) radii and other structural properties of a systematically selected sample of young, massive star clusters (YMCs, $\geq$$5\times10^3$ M$_{\odot}$ and $\leq$200 Myr) in two nearby spiral galaxies, NGC 628 and NGC 1313. We use Hubble Space Telescope WFC3/UVIS and archival ACS/WFC data obtained by the Legacy Extragalactic UV Survey (LEGUS), an HST Treasury Program. We measure effective radii with GALFIT, a two-dimensional image-fitting package, and with a new technique to estimate effective radii from the concentration index (CI) of observed clusters. The distribution of effective radii from both techniques spans $\sim$0.5-10 pc and peaks at 2-3 pc for both galaxies. We find slight positive correlations between effective radius and cluster age in both galaxies, but no significant relationship between effective radius and galactocentric distance. Clusters in NGC 1313 display a mild increase in effective radius with cluster mass, but the trend disappears when the sample is divided into age bins. We show that the vast majority of the clusters in both galaxies are much older than their dynamical times, suggesting they are gravitationally bound objects. We find that about half of the clusters in NGC 628 are underfilling their Roche lobes, based on their Jacobi radii. Our results suggest that the young, massive clusters in NGC 628 and NGC 1313 are expanding due to stellar mass loss or two-body relaxation and are not significantly influenced by the tidal fields of their host galaxies., Comment: 21 pages, 12 figures. Accepted for publication in ApJ. Contact first author for machine-readable tables
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- 2017
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10. Legacy ExtraGalactic UV Survey with The Hubble Space Telescope. Stellar cluster catalogues and first insights into cluster formation and evolution in NGC 628
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Adamo, A., Ryon, J. E., Messa, M., Kim, H., Grasha, K., Cook, D. O., Calzetti, D., Lee, J. C., Whitmore, B. C., Elmegreen, B. G., Ubeda, L., Smith, L. J., Bright, S. N., Runnholm, A., Andrews, J. E., Fumagalli, M., Gouliermis, D. A., Kahre, L., Nair, P., Thilker, D., Walterbos, R., Wofford, A., Aloisi, A., Ashworth, G., Brown, T. M., Chandar, R., Christian, C., Cignoni, M., Clayton, G. C., Dale, D. A., de Mink, S. E., Dobbs, C., Elmegreen, D. M., Evans, A. S., Gallagher III, J. S., Grebel, E. K., Herrero, A., Hunter, D. A., Johnson, K. E., Kennicutt, R. C., Krumholz, M. R., Lennon, D., Levay, K., Martin, C., Nota, A., Ostlin, G., Pellerin, A., Prieto, J., Regan, M. W., Sabbi, E., Sacchi, E., Schaerer, D., Shabani, D. Schiminovich F., Tosi, M., Van Dyk, S. D., and Zackrisson, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the large effort which is producing comprehensive high-level young star cluster (YSC) catalogues for a significant fraction of galaxies observed with the Legacy ExtraGalactic UV Survey (LEGUS) Hubble treasury program. We present the methodology developed to extract cluster positions, verify their genuine nature, produce multiband photometry (from NUV to NIR), and derive their physical properties via spectral energy distribution fitting analyses. We use the nearby spiral galaxy NGC628 as a test case for demonstrating the impact that LEGUS will have on our understanding of the formation and evolution of YSCs and compact stellar associations within their host galaxy. Our analysis of the cluster luminosity function from the UV to the NIR finds a steepening at the bright end and at all wavelengths suggesting a dearth of luminous clusters. The cluster mass function of NGC628 is consistent with a power-law distribution of slopes $\sim -2$ and a truncation of a few times $10^5$ M$_\odot$. After their formation YSCs and compact associations follow different evolutionary paths. YSCs survive for a longer timeframe, confirming their being potentially bound systems. Associations disappear on time scales comparable to hierarchically organized star-forming regions, suggesting that they are expanding systems. We find mass-independent cluster disruption in the inner region of NGC628, while in the outer part of the galaxy there is little or no disruption. We observe faster disruption rates for low mass ($\leq$ $10^4$ M$_\odot$) clusters suggesting that a mass-dependent component is necessary to fully describe the YSC disruption process in NGC628., Comment: accepted for publication in ApJ; 27 pages; complete stellar cluster catalogues will be released in June 2017 at https://legus.stsci.edu
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- 2017
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11. Factors Driving the Difference in Quality of Recovery Scores Between Scheduled and Unscheduled Cesarean Delivery Patients
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Bhiladvala, C., French-O’Carroll, R., Dadkhah, Y., Bright, S., Chau, A., and Seligman, K.M.
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- 2022
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12. Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33
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Okragly AJ, Corwin KB, Elia M, He D, Schroeder O, Zhang Q, Shiyanova T, Bright S, Dicker SB, Chlewicki L, Truhlar SME, Davies J, Patel CN, and Benschop RJ
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il-33 ,th2 immune response ,monoclonal antibody ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Angela J Okragly,1 Katie Brannon Corwin,2 Marikka Elia,3 Dongmei He,3 Oliver Schroeder,3 Qing Zhang,3 Tatiyana Shiyanova,2 Stuart Bright,1 Sarah B Dicker,4 Lukasz Chlewicki,4 Stephanie ME Truhlar,3 Julian Davies,3 Chetan N Patel,2 Robert J Benschop1 1Immunology Research, Eli Lilly and Company, Indianapolis, IN, USA; 2BioTechnology Discovery Research, Eli Lilly and Company, Indianapolis, IN, USA; 3BioTechnology Discovery Research Eli Lilly and Company, San Diego, CA, USA; 4ADME, Eli Lilly and Company, Indianapolis, IN, USACorrespondence: Angela J OkraglyImmunology Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USATel +1- 317-276-2839Email okragly_angela@lilly.comBackground: Interleukin-33 (IL-33) is an alarmin that is released following cellular damage, mechanical injury, or necrosis. It is a member of the IL-1 family and binds to a heterodimer receptor consisting of ST2 and IL-1RAP to induce the production of a wide range of cellular mediators, including the type 2 cytokines IL-4, IL-5 and IL-13. This relationship has led to the hypothesis that the IL-33/ST2 pathway is a driver of allergic disease and inhibition of the IL-33 and ST2 association could have therapeutic benefit.Methods: In this paper, we describe the selection of a phage antibody through the ability to bind human IL-33 and block IL-33/ST2 interaction. This hit antibody was then affinity matured by site-directed mutagenesis of the antibody complementarity-determining regions (CDRs). Further characterization of a fully human monoclonal antibody (mAb), torudokimab (LY3375880) included demonstration of human IL-33 neutralization activity in vitro with an NFκB reporter assay and IL-33 induced mast cell cytokine secretion assay, followed by an in vivo IL-33-induced pharmacodynamic inhibition assay in mice that used IL-5 production as the endpoint.Results: Torudokimab is highly specific to IL-33 and does not bind any of the other IL-1 family members. Furthermore, torudokimab binds human and cynomolgus monkey IL-33 with higher affinity than the binding affinity of IL-33 to ST2, but does not bind mouse, rat, or rabbit IL-33. Torudokimab’s half-life in cynomolgous monkey projects monthly dosing in the clinic.Conclusion: Due to torudokimab’s high affinity, its ability to completely neutralize IL-33 activity in vitro and in vivo, and the observed cynomolgus monkey pharmacokinetic properties, this molecule was selected for clinical development.Keywords: IL-33, Th2 immune response, monoclonal antibody
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- 2021
13. The Spatial Distribution of the Young Stellar Clusters in the Star Forming Galaxy NGC 628
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Grasha, K., Calzetti, D., Adamo, A., Kim, H., Elmegreen, B. G., Gouliermis, D. A., Aloisi, A., Bright, S. N., Christian, C., Cignoni, M., Dale, D. A., Dobbs, C., Elmegreen, D. M., Fumagalli, M., Gallagher III, J. S., Grebel, E. K., Johnson, K. E., Lee, J. C., Messa, M., Smith, L. J., Ryon, J. E., Thilker, D., Ubeda, L., and Wofford, A.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present a study of the spatial distribution of the stellar cluster populations in the star forming galaxy NGC 628. Using Hubble Space Telescope broad band WFC3/UVIS UV and optical images from the Treasury Program LEGUS (Legacy ExtraGalactic UV Survey), we have identified 1392 potential young (<100 Myr) stellar clusters within the galaxy, identified from a combination of visual inspection and automatic selection. We investigate the clustering of these young stellar clusters and quantify the strength and change of clustering strength with scale using the two-point correlation function. We also investigate how image boundary conditions and dust lanes affect the observed clustering. The distribution of the clusters is well fit by a broken power law with negative exponent $\alpha$. We recover a weighted mean index of $\alpha$ ~ -0.8 for all spatial scales below the break at 3".3 (158 pc at a distance of 9.9 Mpc) and an index of $\alpha$ ~ -0.18 above 158 pc for the accumulation of all cluster types. The strength of the clustering increases with decreasing age and clusters older than 40 Myr lose their clustered structure very rapidly and tend to be randomly distributed in this galaxy whereas the mass of the star cluster has little effect on the clustering strength. This is consistent with results from other studies that the morphological hierarchy in stellar clustering resembles the same hierarchy as the turbulent interstellar medium., Comment: 18 pages, 18 figures, 1 table. Accepted for publication in The Astrophysical Journal. The HST images of Figure 1 are degraded in order to comply with the size requirement of arXiv
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- 2015
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14. The Brightest Young Star Clusters in NGC 5253
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Calzetti, D., Johnson, K. E., Adamo, A., Gallagher III, J. S., Andrews, J. E., Smith, L. J., Clayton, G. C., Lee, J. C., Sabbi, E., Ubeda, L., Kim, H., Ryon, J. E., Thilker, D., Bright, S. N., Zackrisson, E., Kennicutt, R. C., de Mink, S. E., Whitmore, B. C., Aloisi, A., Chandar, R., Cignoni, M., Cook, D., Dale, D. A., Elmegreen, B. G., Elmegreen, D. M., Evans, A. S., Fumagalli, M., Gouliermis, D. A., Grasha, K., Grebel, E. K., Krumholz, M. R., Walterbos, R., Wofford, A., Brown, T. M., Christian, C., Dobbs, C., Herrero, A., Kahre, L., Messa, M., Nair, P., Nota, A., Oestlin, G., Pellerin, A., Sacchi, E., Schaerer, D., and Tosi, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
The nearby dwarf starburst galaxy NGC5253 hosts a number of young, massive star clusters, the two youngest of which are centrally concentrated and surrounded by thermal radio emission (the `radio nebula'). To investigate the role of these clusters in the starburst energetics, we combine new and archival Hubble Space Telescope images of NGC5253 with wavelength coverage from 1500 Ang to 1.9 micron in 13 filters. These include H-alpha, P-beta, and P-alpha, and the imaging from the Hubble Treasury Program LEGUS (Legacy Extragalactic UV Survey). The extraordinarily well-sampled spectral energy distributions enable modeling with unprecedented accuracy the ages, masses, and extinctions of the 9 optically brightest clusters (M_V < -8.8) and the two young radio nebula clusters. The clusters have ages ~1-15 Myr and masses ~1x10^4 - 2.5x10^5 M_sun. The clusters' spatial location and ages indicate that star formation has become more concentrated towards the radio nebula over the last ~15 Myr. The most massive cluster is in the radio nebula; with a mass 2.5x10^5 M_sun and an age ~1 Myr, it is 2-4 times less massive and younger than previously estimated. It is within a dust cloud with A_V~50 mag, and shows a clear nearIR excess, likely from hot dust. The second radio nebula cluster is also ~1 Myr old, confirming the extreme youth of the starburst region. These two clusters account for about half of the ionizing photon rate in the radio nebula, and will eventually supply about 2/3 of the mechanical energy in present-day shocks. Additional sources are required to supply the remaining ionizing radiation, and may include very massive stars., Comment: 67 pages; 11 figures; 7 tables. Accepted for publication in the Astrophysical Journal
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- 2015
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15. Legacy ExtraGalactic UV Survey (LEGUS) with The Hubble Space Telescope. I. Survey Description
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Calzetti, D., Lee, J. C., Sabbi, E., Adamo, A., Smith, L. J., Andrews, J. E., Ubeda, L., Bright, S. N., Thilker, D., Aloisi, A., Brown, T. M., Chandar, R., Christian, C., Cignoni, M., Clayton, G. C., da Silva, R., de Mink, S. E., Dobbs, C., Elmegreen, B. G., Elmegreen, D. M., Evans, A. S., Fumagalli, M., Gallagher, J. S., Gouliermis, D. A., Grebel, E. K., Herrero, A., Hunter, D. A., Johnson, K. E., Kennicutt, R. C., Kim, H., Krumholz, M. R., Lennon, D., Levay, K., Martin, C., Nair, P., Nota, A., Oestlin, G., Pellerin, A., Prieto, J., Regan, M. W., Ryon, J. E., Schaerer, D., Schiminovich, D., Tosi, M., Van Dyk, S. D., Walterbos, R., Whitmore, B. C., and Wofford, A.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Legacy ExtraGalactic UV Survey (LEGUS) is a Cycle 21 Treasury program on the Hubble Space Telescope, aimed at the investigation of star formation and its relation with galactic environment in nearby galaxies, from the scales of individual stars to those of ~kpc-size clustered structures. Five-band imaging, from the near-ultraviolet to the I-band, with the Wide Field Camera 3, plus parallel optical imaging with the Advanced Camera for Surveys, is being collected for selected pointings of 50 galaxies within the local 12 Mpc. The filters used for the observations with the Wide Field Camera 3 are: F275W(2,704 A), F336W(3,355 A), F438W(4,325 A), F555W(5,308 A), and F814W(8,024 A); the parallel observations with the Advanced Camera for Surveys use the filters: F435W(4,328 A), F606W(5,921 A), and F814W(8,057 A). The multi-band images are yielding accurate recent (<~50 Myr) star formation histories from resolved massive stars and the extinction-corrected ages and masses of star clusters and associations. The extensive inventories of massive stars and clustered systems will be used to investigate the spatial and temporal evolution of star formation within galaxies. This will, in turn, inform theories of galaxy evolution and improve the understanding of the physical underpinning of the gas-star formation relation and the nature of star formation at high redshift. This paper describes the survey, its goals and observational strategy, and the initial science results. Because LEGUS will provide a reference survey and a foundation for future observations with JWST and with ALMA, a large number of data products are planned for delivery to the community., Comment: 67 pages, 9 figures; accepted for publication on the Astronomical Journal
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- 2014
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16. The RCB star V854 Cen is surrounded by a hot dusty shell
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Chesneau, Olivier, Millour, Florentin, De Marco, Orsola, Bright, S. N., Spang, Alain, Lagadec, Eric, Mékarnia, Djamel, and de Wit, W. J.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims : The hydrogen-deficient supergiants known as R Coronae Borealis (RCB) stars might be the result of a double-degenerate merger of two white dwarfs (WDs), or a final helium shell flash in a planetary nebula central star. In this context, any information on the geometry of their circumstellar environment and, in particular, the potential detection of elongated structures, is of great importance. Methods : We obtained near-IR observations of V854 Cen with the AMBER recombiner located at the Very Large Telescope Interferometer (VLTI) array with the compact array (B$\leq$35m) in 2013 and the long array (B$\leq$140m) in 2014. At each time, V854 Cen was at maximum light. The $H$- and $K$-band continua were investigated by means of spectrally dependant geometric models. These data were supplemented with mid-IR VISIR/VLT images. Results : A dusty slightly elongated over density is discovered both in the $H$- and $K$-band images. With the compact array, the central star is unresolved ($\Theta\leq2.5$\,mas), but a flattened dusty environment of $8 \times 11$ mas is discovered whose flux increases from about $\sim$20% in the $H$ band to reach about $\sim$50% at 2.3$\micron$, which indicates hot (T$\sim$1500\,K) dust in the close vicinity of the star. The major axis is oriented at a position angle (P.A.) of 126$\pm$29$\deg$. Adding the long-array configuration dataset provides tighter constraints on the star diameter ($\Theta\leq1.0$ mas), a slight increase of the overdensity to $12 \times 15$ mas and a consistent P.A. of 133$\pm$49$\deg$. The closure phases, sensitive to asymmetries, are null and compatible with a centro-symmetric, unperturbed environment excluding point sources at the level of 3% of the total flux in 2013 and 2014. The VISIR images exhibit a flattened aspect ratio at the 15-20% level at larger distances ($\sim$1$\arcsec$) with a position angle of 92$\pm$19$\deg$, marginally consistent with the interferometric observations. Conclusions : This is the first time that a moderately elongated structure has been observed around an RCB star. These observations confirm the numerous suggestions for a bipolar structure proposed for this star in the literature, which were mainly based on polarimetric and spectroscopic observations., Comment: Accepted by A\&A, new version after language editing, Astronomy and Astrophysics (2014)
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- 2014
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17. V838 Monocerotis: the central star and its environment a decade after outburst
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Chesneau, Olivier, Millour, Florentin, De Marco, Orsola, Bright, S. N., Spang, Alain, Banerjee, D. P. K., Ashok, N. M., Kaminski, T., Wisniewski, John P., Meilland, Anthony, and Lagadec, Eric
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims. V838 Monocerotis erupted in 2002, brightened in a series of outbursts, and eventually developed a spectacular light echo. A very red star emerged a few months after the outburst. The whole event has been interpreted as the result of a merger. Methods. We obtained near-IR and mid-IR interferometric observations of V838 Mon with the AMBER and MIDI recombiners located at the Very Large Telescope Interferometer (VLTI) array. The MIDI two-beam observations were obtained with the 8m Unit Telescopes between October 2011 and February 2012. The AMBER three-beam observations were obtained with the compact array (B$\leq$m) in April 2013 and the long array (B$\leq$140m) in May 2014, using the 1.8m Auxiliary Telescopes. Results. A significant new result is the detection of a compact structure around V838 Mon, as seen from MIDI data. The extension of the structure increases from a FWHM of 25 mas at 8 {\mu}m to 70 mas at 13 {\mu}m. At the adopted distance of D = 6.1 $\pm$ 0.6 kpc, the dust is distributed from about 150 to 400 AU around V838 Mon. The MIDI visibilities reveal a flattened structure whose aspect ratio increases with wavelength. The major axis is roughly oriented around a position angle of -10 degrees, which aligns with previous polarimetric studies reported in the literature. This flattening can be interpreted as a relic of the 2002 eruption or by the influence of the currently embedded B3V companion. The AMBER data provide a new diameter for the pseudo-photosphere, which shows that its diameter has decreased by about 40% in 10yrs, reaching a radius R$_*$ = 750 $\pm$ 200 R$_{\odot}$ (3.5 $\pm$ 1.0 AU). Conclusions. After the 2002 eruption, interpreted as the merging of two stars, it seems that the resulting source is relaxing to a normal state. The nearby environment exhibits an equatorial over-density of dust up to several hundreds of AU., Comment: Astronomy and Astrophysics (2014) Will be set by the publisher
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- 2014
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18. The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways
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Seth A. Domfeh, Patrick W. Narkwa, Osbourne Quaye, Kwadwo A. Kusi, Bright S. Addy, Sian Lant, Rebecca P. Sumner, Carlos Maluquer de Motes, Gordon A. Awandare, Charles Ansah, and Mohamed Mutocheluh
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Immunologic diseases. Allergy ,RC581-607 - Abstract
Type 1 interferons (IFN-1) are pleiotropic cytokines with well-established anticancer and antiviral properties, particularly in mucosal tissues. Hence, natural IFN-1-inducing treatments are highly sought after in the clinic. Here, we report for the first time that cryptolepine, a pharmacoactive alkaloid in the medicinal plant Cryptolepis sanguinolenta, is a potent IFN-1 pathway inducer. Cryptolepine increased the transcript levels of JAK1, TYK2, STAT1, STAT2, IRF9, and OAS3, as well as increased the accumulation of STAT1 and OAS3 proteins, similar to recombinant human IFN-α. Cryptolepine effects were observed in multiple cell types including a model of human macrophages. This response was maintained in MAVS and STING-deficient cell lines, suggesting that cryptolepine effects are not mediated by nucleic acids released upon nuclear or organelle damage. In agreement, cryptolepine did not affect cell viability in concentrations that triggered potent IFN-1 activation. In addition, we observed no differences in the presence of a pharmacological inhibitor of TBK1, a pleiotropic kinase that is a converging point for Toll-like receptors (TLRs) and nucleic acid sensors. Together, our results demonstrate that cryptolepine is a strong inducer of IFN-1 response and suggest that cryptolepine-based medications such as C. sanguinolenta extract could be potentially tested in resource-limited regions of the world for the management of chronic viral infections as well as cancers.
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- 2022
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19. Potential Impacts of Agricultural Intensification and Climate Change on the Livelihoods of Farmers in Nioro, Senegal, West Africa
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MacCarthy, Dilys S., primary, Hathie, Ibrahima, additional, Freduah, Bright S., additional, Ly, Mouhamed, additional, Adam, Myriam, additional, Ly, Amoudou, additional, Nenkam, Andree, additional, Traore, Pierre S., additional, and Valdivia, Roberto O., additional
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- 2021
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20. Understanding Differences in Climate Sensitivity Simulations of APSIM and DSSAT Crop Models
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Boote, Kenneth J., primary, Adam, Myriam, additional, Ahmad, Ishfaq, additional, Ahmad, Shakeel, additional, Cammarano, Davide, additional, Chattha, Ashfaq Ahmad, additional, Claessens, Lieven, additional, Dimes, John, additional, Durand, Wiltrud, additional, Freduah, Bright S., additional, Gummadi, Sridhar, additional, Hargreaves, John, additional, Hoogenboom, Gerrit, additional, Homann-Kee Tui, Sabine, additional, Jones, James W., additional, Khaliq, Tasneem, additional, MacCarthy, Dilys S., additional, Masikati, Patricia, additional, McDermid, Sonali, additional, Kadiyala, Dakshina Murthy, additional, Nenkam, Andree, additional, Porter, Cheryl, additional, Ruane, Alex C., additional, Subash, Nataraja, additional, Thorburn, Peter, additional, Traore, Pierre S., additional, Vellingiri, Geethalakshmi, additional, and Wajid, Syed Aftab, additional
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- 2021
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21. Productivity of Soybean under Projected Climate Change in a Semi-Arid Region of West Africa: Sensitivity of Current Production System
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Dilys S. MacCarthy, Pierre S. Traore, Bright S. Freduah, Samuel G. K. Adiku, Daniel E. Dodor, and Samuel K. Kumahor
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climate change ,agriculture ,Ghana ,climate variability ,elevated atmospheric carbon dioxide ,Agriculture - Abstract
The production of soybean is gaining more attention in West Africa. In light of projected changes in climate, there is a need to assess the potential impacts on yield productivity and variability among farmers. An evaluated GROPGRO module of the Decision Support System for Agro-technological Transfer (DSSAT) was used to simulate soybean productivity under both historical (1980–2009) and projected climate scenarios from multiple general circulation models (GCMs) under two representative concentration pathways (RCPs): 4.5 and 8.5. Agronomic data from 90 farms, as well as multiple soil profile data, were also used for the impact assessment. Climate change leads to a reduction (3% to 13.5% across GCMs and RCPs) in the productivity of soybean in Northern Ghana. However, elevated atmospheric carbon dioxide has the potential to offset the negative impact, resulting in increased (14.8% to 31.3% across GCMs and RCPs) productivity. The impact of climate change on yield varied widely amongst farms (with relative standard deviation (RSD) ranging between 17% and 35%) and across years (RSD of between 10% and 15%). Diversity in management practices, as well as differences in soils, explained the heterogeneity in impact among farms. Variability among farms was higher than that among years. The strategic management of cultural practices provides an option to enhance the resilience of soybean productivity among smallholders.
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- 2022
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22. Observing Compact Disks Inside Pre-Planetary Nebulae with the Very Large Telescope Interferometer
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Bright, S. N., De Marco, O., Chesneau, O., Lagadec, E., Van Winckel, H., and Hrivnak, B. J.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
AGB stars appear to lose mass spherically, but many PNe resulting from the AGB mass-loss have non-spherical morphologies. Compact disks have been found in some bipolar PNe, but their role in the shaping process remains unknown. Compact Keplarian disks are found to be common around post-AGB binaries, however, these objects may never develop into PNe. Another group of post-AGB stars, known as pre-PNe, are surrounded by collimated nebulae shining by reflected light or shock ionisation. We are observing the inner circumstellar regions of pre-PNe at high angular resolutions with the VLTI. We seek to compare pre-PNe disks to those around other post-AGB stars and PNe. New observations of the pre-PN, IRAS 16279-4757, show evidence for a disk similar to those seen in young PNe., Comment: IAU 283 conference proceedings
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- 2011
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23. VLTI observations of the dust geometry around R Coronae Borealis stars
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Bright, S. N., Chesneau, O., Clayton, G. C., De Marco, O., Leão, I. C., Nordhaus, J., and Gallagher, J. S.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We are investigating the formation and evolution of dust around the hydrogen-deficient supergiants known as R Coronae Borealis (RCB) stars. We aim to determine the connection between the probable merger past of these stars and their current dust-production activities. We carried out high-angular resolution interferometric observations of three RCB stars, namely RY Sgr, V CrA, and V854 Cen with the mid-IR interferometer, MIDI on the VLTI, using two telescope pairs. The baselines ranged from 30 to 60 m, allowing us to probe the dusty environment at very small spatial scales (~ 50 mas or 400 stellar radii). The observations of the RCB star dust environments were interpreted using both geometrical models and one-dimensional radiative transfer codes. From our analysis we find that asymmetric circumstellar material is apparent in RY Sgr, may also exist in V CrA, and is possible for V854 Cen. Overall, we find that our observations are consistent with dust forming in clumps ejected randomly around the RCB star so that over time they create a spherically symmetric distribution of dust. However, we conclude that the determination of whether there is a preferred plane of dust ejection must wait until a time series of observations are obtained., Comment: Accepted for publication in MNRAS; 14 pages, 10 figures, 6 tables
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- 2011
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24. AgMIP Regional Integrated Assessment of Agricultural Systems in Nioro, Senegal: Representative Agricultural Pathways, Climate, Crop and Economic Datasets
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Ibrahima Hathie, Dilys S. MacCarthy, Bright S. Freduah, Mouhamed Ly, Ahmadou Ly, Roberto O. Valdivia, Alex C. Ruane, John Antle, Carolyn Z. Mutter, Gerrit Hoogenboom, and Cheryl H. Porter
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Meteorology And Climatology ,Life Sciences (General) - Abstract
This paper describes the datasets that were used to implement an AgMIP Regional Integrated Assessment for the Nioro region of Senegal to assess the potential impacts of climate change on the principal agricultural system in the Senegal peanut basin and to assess adaptations of that system to climate change under current as well as future climate and socio-economic conditions. This dataset includes the Representative Agricultural Pathways developed for Nioro from 2000-2050; the climate data that were used to implement crop yield simulations; the data that were used to parameterize the DSSAT and APSIM crop models, including historical climate data and future climate scenarios; and the data that were used to parameterize the Tradeoff Analysis Model for Multi-dimensional Impact Assessment (TOAMD) economic simulation model, as well as simulated model outputs.
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- 2022
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25. Cryptolepis nigrescens (Wennberg) L. Joubert. and Bruyns., Prosopsis africana (Guill. and Perr.) Taub. and Pterygota macrocarpa K. Schum. traditionally used to manage tumors in Ghana: A review of preclinical evidence.
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Afolayan, Oluwatomisin D., primary, Firempong, Caleb K., additional, Komlaga, Gustav, additional, Addo-Fordjour, Patrick, additional, Addy, Bright S., additional, and Emikpe, Benjamin O., additional
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- 2023
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26. Impaired layer specific retinal vascular reactivity among diabetic subjects.
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Maxwell Singer, Bright S Ashimatey, Xiao Zhou, Zhongdi Chu, Ruikang Wang, and Amir H Kashani
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Medicine ,Science - Abstract
PurposeTo investigate layer specific retinal vascular reactivity (RVR) in capillaries of diabetic subjects without DR or with only mild non-proliferative diabetic retinopathy (NPDR).MethodsA previously described nonrebreathing apparatus was used to deliver room air, 5% CO2, or 100% O2 to 41 controls and 22 diabetic subjects (with mild or no NPDR) while simultaneously acquiring fovea-centered 3x3mm2 Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) images. Vessel skeleton density (VSD) and vessel diameter index (VDI) were calculated for each gas condition for the superficial retinal layer (SRL) and deep retinal layer (DRL). The superficial layer analysis excluded arterioles and venules. Data analysis was performed using mixed factorial analysis of covariance stratified by diabetic status. All models were adjusted for age, gender, and hypertension, and statistical significance for multiple comparisons from posthoc comparisons were defined at pResultsAmong controls, there was a significant difference in capillary VSD between all gas conditions (pConclusionsImpairment in RVR in diabetic subjects is characterized by a paradoxical response to CO2 in both the SRL and DRL as well as an attenuated response to O2 in the DRL. These layer and gas specific impairments in diabetics seem to occur early in the disease and to be driven primarily at the capillary level.
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- 2020
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27. Lower retinal capillary density in minimal cognitive impairment among older Latinx adults
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Bright S. Ashimatey, Lina M. D'Orazio, Samantha J. Ma, Kay Jann, Xuejuan Jiang, Hanzhang Lu, Danny J.J. Wang, John M. Ringman, and Amir H. Kashani
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capillary ,clinical dementia rating (CDR) ,cerebrovascular reactivity ,Fazekas scale ,Montreal Cognitive Assessment (MoCA) ,optical coherence tomography angiography (OCTA) ,Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Abstract
Abstract Introduction We investigated the hypothesis that retinal capillary perfusion is a biomarker of early cognitive decline and cerebrovascular perfusion associated with small vessel disease in a pilot data set of Latinx adults at high risk for vascular cognitive impairment and dementia. Methods High‐resolution optical coherence tomography angiography (OCTA) images were acquired from dilated eyes of Latinx subjects using a 3 × 3 mm2 scan pattern from a commercially available device. A previously validated method was used to quantify the density of perfused retinal capillaries as the retinal vessel skeleton density (VSD). The association of VSD with Clinical Dementia Rating Sum of Boxes, total Montreal Cognitive Assessment (MoCA) score, and individual MoCA test elements were analyzed using multivariate statistics that adjusted for confounders. VSD was also compared with magnetic resonance imaging (MRI) measures of cerebrovascular reactivity (CVR) and perfusion in the middle cerebral artery perforator (MCA‐Perf) territory. Results The mean (± SD) age of the subjects was 68 (± 6) years. For every 0.01‐unit lower VSD, the risk of having a CDR‐SOB >0 was 20% higher (95%CI = 5%–90%; P = .031). Similarly, a lower VSD was associated with lower total MoCA score (r = 0.3; P = .038). The Visuospatial/Executive domain of the MoCA assessment showed the strongest association with VSD (β = 0.02; P = .022). Lower retinal VSD was associated with worse MRI measure of CVR (r = 0.7, P = .04) and less perfusion in the MCA‐Perf territory (r = 0.45, P = .02). Discussion Impaired retinal capillary perfusion is associated with cognitive impairment and abnormalities in cerebrovascular perfusion and function. OCTA‐based retinal capillary assessment holds promise for identifying and quantifying retinal correlates of neurovascular abnormalities associated with vascular cognitive impairment.
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- 2020
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28. Effective Hamiltonian Approach to Hyperon Beta Decay with Final-State Baryon Polarization
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Bright, S., Winston, R., Swallow, E. C., and Alavi-Harati, A.
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High Energy Physics - Phenomenology - Abstract
Using an effective Hamiltonian approach, we obtain expressions for hyperon beta decay final-state baryon polarization. Terms through second order in the energy release are retained. The resulting approximate expressions are much simpler and more compact than the exact expressions, and they agree closely with them., Comment: 1 Figure Will appear in Phys Rev D 60 Article 117505 (Dec 1, 1999)
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- 1999
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29. Has the Internet Reduced Friendship? Scientific Relationships in Ghana, Kenya, and India, 1994-2010
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Shrum, Wesley, Palackal, Antony, Dzorgbo, Dan-Bright S., Mbatia, Paul, Schafer, Mark, Miller, Paige, and Rackin, Heather
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- 2017
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30. Cortical event-related potentials in preclinical familial Alzheimer disease
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Golob, EJ, Ringman, JM, Irimajiri, R, Bright, S, Schaffer, B, Medina, LD, and Starr, A
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Brain Disorders ,Acquired Cognitive Impairment ,Clinical Research ,Dementia ,Alzheimer's Disease ,Neurodegenerative ,Genetics ,Aging ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Acoustic Stimulation ,Adult ,Alzheimer Disease ,Auditory Perception ,Brain ,Cognition ,DNA Mutational Analysis ,Electroencephalography ,Event-Related Potentials ,P300 ,Evoked Potentials ,Family ,Female ,Genotype ,Humans ,Male ,Mutation ,Neuropsychological Tests ,Time Factors ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ObjectiveTo define changes in cortical function in persons inheriting familial Alzheimer disease (FAD) mutations before the onset of cognitive decline.MethodsTwenty-six subjects with a family history of FAD were divided into 2 subgroups according to genotype (FAD mutation carriers, n = 15; FAD noncarriers, n = 11). Subjects were given standardized tests of cognitive function and the Clinical Dementia Rating scale (CDR). Sensory (P50, N100, P200) and cognitive (N200, P300) event-related potentials were recorded during an auditory discrimination task. Amplitudes and latencies of cortical potentials were compared among FAD mutation carriers and noncarriers.ResultsFAD mutation carriers and noncarriers did not significantly differ in age or on measures of cognitive function, but FAD carriers had a greater incidence of 0.5 CDR scores (1/10 noncarriers, 5/15 carriers). Relative to noncarriers, FAD mutation carriers had significantly longer latencies of the N100, P200, N200, and P300 components, and smaller slow wave amplitudes. Subanalyses of subjects having CDR scores of 0.0 also showed latency increases in FAD mutation carriers.ConclusionsAuditory sensory and cognitive cortical potentials in persons with familial Alzheimer disease (FAD) mutations are abnormal approximately 10 years before dementia will be manifest. Longer event-related potential latencies suggest slowing of cortical information processing in FAD mutation carriers.
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- 2009
31. Modeling the effect of soil fertility management options on maize yield stability under variable climate in a sub-humid zone in Ghana
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MacCarthy, Dilys S., primary, Adamtey, Noah, additional, Freduah, Bright S., additional, Fosu-Mensah, Benedicta Y., additional, Ofosu-Budu, Godfred K., additional, and Fliessbach, Andreas, additional
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- 2023
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32. Dosing and Therapeutic Conduct in Administration Sessions in Substance-Assisted Psychotherapy: A Systematized Review
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Thal, S. B., primary, Wieberneit, M., additional, Sharbanee, J. M., additional, Skeffington, P. M., additional, Bruno, R., additional, Wenge, T., additional, and Bright, S. J., additional
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- 2023
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33. Therapeutic Frameworks in Integration Sessions in Substance-Assisted Psychotherapy: A Systematized Review
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Thal, Sascha, Baker, Paris, Marinis, J., Wieberneit, M., Sharbanee, Jason, Bruno, R., Skeffington, Petra, Bright, S., Thal, Sascha, Baker, Paris, Marinis, J., Wieberneit, M., Sharbanee, Jason, Bruno, R., Skeffington, Petra, and Bright, S.
- Abstract
Serotonergic psychedelics and related substances have been explored as potential adjuncts in substance-assisted psychotherapy (SAPT) for treating various disorders. SAPT can be divided into three phases: preparation, administration, and integration. Integration is commonly defined as the comprehension and effective application of insights from psychedelic experiences into everyday life. However, there is limited research regarding the most appropriate therapeutic approach during integration sessions in SAPT. In this article, we discuss the current evidence for different therapeutic frameworks for integrations sessions when serotonergic psychedelics and entactogens are used as adjuncts to psychotherapy. We conducted a systematized review of the literature following PRISMA guidelines and searched PsycINFO, MEDLINE, and Cochrane Library databases. The final synthesis included 75 clinical trials, mixed-methods investigations, treatment manuals, study protocols, quasi-experiments, qualitative investigations, descriptive studies, opinion papers, reviews, books and book chapters, published until November 11, 2022. The effects that various therapeutic approaches for integration sessions have on therapeutic outcome have not been investigated by means of rigorous research. Most of the available evidence we retrieved was not supported by empirical data, thus limiting any conclusive statements regarding appropriate therapeutic frameworks for integration sessions for SAPT. Current clinical studies have used a range of therapeutic frameworks with the majority drawing from the humanistic-experiential tradition. While integration is regarded as crucial for the safe application of SAPTHowever, there is currently an insufficient evidence base to suggest that any type of therapy is most effective for guiding integration sessions. Systematic investigation of different therapeutic frameworks for integration and additional therapy-related factors is needed.
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- 2023
34. Scale-up of a novel vital signs alert device to improve maternity care in Sierra Leone: a mixed methods evaluation of adoption.
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Bright, S, Moses, F, Ridout, A, Sam, B, Momoh, M, Goodhart, V, Smart, F, Mannah, M, Issa, S, Herm-Singh, S, Reid, F, Seed, PT, Bunn, J, Shennan, A, Augustin, K, Sandall, J, Bright, S, Moses, F, Ridout, A, Sam, B, Momoh, M, Goodhart, V, Smart, F, Mannah, M, Issa, S, Herm-Singh, S, Reid, F, Seed, PT, Bunn, J, Shennan, A, Augustin, K, and Sandall, J
- Abstract
BACKGROUND: The CRADLE (Community blood pressure monitoring in Rural Africa: Detection of underLying pre-Eclampsia) Vital Signs Alert device-designed specifically to improve maternity care in low resource settings-had varying impact when trialled in different countries. To better understand the contextual factors that may contribute to this variation, this study retrospectively evaluated the adoption of CRADLE, during scale-up in Sierra Leone. METHODS: This was a mixed methods study. A quantitative indicator of adoption (the proportion of facilities trained per district) was calculated from existing training records, then focus groups were held with 'CRADLE Champions' in each district (n = 32), to explore adoption qualitatively. Template Analysis was used to deductively interpret qualitative data, guided by the NASSS (non-adoption, abandonment, scale-up, spread, sustainability) Framework. FINDINGS: Substantial but non-significant variation was found in the proportion of facilities trained in each district (range 59-90%) [X2 (7, N = 8) = 10.419, p = 0.166]. Qualitative data identified complexity in two NASSS domains that may have contributed to this variation: 'the technology' (for example, charging issues, difficulty interpreting device output and concerns about ongoing procurement) and 'the organisation' (for example, logistical barriers to implementing training, infighting and high staff turnover). Key strategies mentioned to mitigate against these issues included: transparent communication at all levels; encouraging localised adaptations during implementation (including the involvement of community leaders); and selecting Champions with strong soft skills (particularly conflict resolution and problem solving). CONCLUSIONS: Complexity related to the technology and the organisational context were found to influence the adoption of CRADLE in Sierra Leone, with substantial inter-district variation. These findings emphasise the importance of gaining an in-depth unders
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- 2023
35. Exploratory Study of the Current Status of the Rights and Welfare of Ghanaian Women : Taking Stock and Mapping Gaps for New Actions
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Dzorgbo, Dan-Bright S. and Gyan, Sylvia Esther
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- 2016
36. The Science Performance of JWST as Characterized in Commissioning
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Rigby, J, Perrin, M, McElwain, M, Kimble, R, Friedman, S, Lallo, M, Doyon, R, Feinberg, L, Ferruit, P, Glasse, A, Rieke, M, Rieke, G, Wright, G, Willott, C, Colon, K, Milam, S, Neff, S, Stark, C, Valenti, J, Abell, J, Abney, F, Abul-Huda, Y, Scott Acton, D, Adams, E, Adler, D, Aguilar, J, Ahmed, N, Albert, L, Alberts, S, Aldridge, D, Allen, M, Altenburg, M, Álvarez-Márquez, J, Alves De Oliveira, C, Andersen, G, Anderson, H, Anderson, S, Argyriou, I, Armstrong, A, Arribas, S, Artigau, E, Arvai, A, Atkinson, C, Bacon, G, Bair, T, Banks, K, Barrientes, J, Barringer, B, Bartosik, P, Bast, W, Baudoz, P, Beatty, T, Bechtold, K, Beck, T, Bergeron, E, Bergkoetter, M, Bhatawdekar, R, Birkmann, S, Blazek, R, Blome, C, Boccaletti, A, Böker, T, Boia, J, Bonaventura, N, Bond, N, Bosley, K, Boucarut, R, Bourque, M, Bouwman, J, Bower, G, Bowers, C, Boyer, M, Bradley, L, Brady, G, Braun, H, Breda, D, Bresnahan, P, Bright, S, Britt, C, Bromenschenkel, A, Brooks, B, Brooks, K, Brown, B, Brown, M, Brown, P, Bunker, A, Burger, M, Bushouse, H, Cale, S, Cameron, A, Cameron, P, Canipe, A, Caplinger, J, Caputo, F, Cara, M, Carey, L, Carniani, S, Carrasquilla, M, Carruthers, M, Case, M, Rigby, J [0000-0002-7627-6551], McElwain, M [0000-0003-0241-8956], Ferruit, P [0000-0001-8895-0606], Rieke, M [0000-0002-7893-6170], Willott, C [0000-0002-4201-7367], and Apollo - University of Cambridge Repository
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Infrared astronomy ,Observatories ,Astronomical instrumentation - Abstract
This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.
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- 2023
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37. Observation of Direct CP Violation in KS,L→ππ Decays
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Alavi-Harati, A, Albuquerque, IF, Alexopoulos, T, Arenton, M, Arisaka, K, Averitte, S, Barker, AR, Bellantoni, L, Bellavance, A, Belz, J, Ben-David, R, Bergman, DR, Blucher, E, Bock, GJ, Bown, C, Bright, S, Cheu, E, Childress, S, Coleman, R, Corcoran, MD, Corti, G, Cox, B, Crisler, MB, Erwin, AR, Ford, R, Glazov, A, Golossanov, A, Graham, G, Graham, J, Hagan, K, Halkiadakis, E, Hanagaki, K, Hidaka, S, Hsiung, YB, Jejer, V, Jennings, J, Jensen, DA, Kessler, R, Kobrak, HGE, LaDue, J, Lath, A, Ledovskoy, A, McBride, PL, McManus, AP, Mikelsons, P, Monnier, E, Nakaya, T, Nauenberg, U, Nelson, KS, Nguyen, H, O'Dell, V, Pang, M, Pordes, R, Prasad, V, Qiao, C, Quinn, B, Ramberg, EJ, Ray, RE, Roodman, A, Sadamoto, M, Schnetzer, S, Senyo, K, Shanahan, P, Shawhan, PS, Slater, W, Solomey, N, Somalwar, SV, Stone, RL, Suzuki, I, Swallow, EC, Swanson, RA, Taegar, SA, Tesarek, RJ, Thomson, GB, Toale, PA, Tripathi, A, Tschirhart, R, Wah, YW, Wang, J, White, HB, Whitmore, J, Winstein, B, Winston, R, Wu, J-Y, Yamanaka, T, and Zimmerman, ED
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Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Mathematical Sciences ,Physical Sciences ,Engineering ,General Physics - Abstract
We have compared the decay rates of KL and KS toΠ+ Π- Π0Π0 final states using a subset of the data from the KTeV experiment (E832) at Fermilab. We find that the direct-CP-violation parameter Re (μ’/μ) is equal to [28.0±3.0(stat)±2.8(syst)]×10-4. This result definitively establishes the existence of CP violation in a decay process. © 1999 The American Physical Society.
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- 1999
38. Observation of direct CP violation in ks, l→ΠΠ decays
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Alavi-Harati, A, Albuquerque, IF, Alexopoulos, T, Arenton, M, Arisaka, K, Averitte, S, Barker, AR, Bellantoni, L, Bellavance, A, Belz, J, Ben David, R, Bergman, DR, Blucher, E, Bock, GJ, Bown, C, Bright, S, Cheu, E, Childress, S, Coleman, R, Corcoran, MD, Corti, G, Cox, B, Crisler, MB, Erwin, AR, Ford, R, Glazov, A, Golossanov, A, Graham, G, Graham, J, Hagan, K, Halkiadakis, E, Hanagaki, K, Hidaka, S, Hsiung, YB, Jejer, V, Jennings, J, Jensen, DA, Kessler, R, Kobrak, HGE, La Due, J, Lath, A, Ledovskoy, A, Mc Bride, PL, Mc Manus, AP, Mikelsons, P, Monnier, E, Nakaya, T, Nauenberg, U, Nelson, KS, Nguyen, H, O’dell, V, Pang, M, Pordes, R, Prasad, V, Qiao, C, Quinn, B, Ramberg, EJ, Ray, RE, Roodman, A, Sadamoto, M, Schnetzer, S, Senyo, K, Shanahan, P, Shawhan, PS, Slater, W, Solomey, N, Somalwar, SV, Stone, RL, Suzuki, I, Swallow, EC, Swanson, RA, Taegar, SA, Tesarek, RJ, Thomson, GB, Toale, PA, Tripathi, A, Tschirhart, R, Wah, YW, Wang, J, White, HB, Whitmore, J, Winstein, B, Winston, R, Wu, JY, Yamanaka, T, and Zimmerman, ED
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Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,General Physics ,Physical Sciences ,Mathematical Sciences ,Engineering - Abstract
We have compared the decay rates of KL and KS toΠ+ Π- Π0Π0 final states using a subset of the data from the KTeV experiment (E832) at Fermilab. We find that the direct-CP-violation parameter Re (μ’/μ) is equal to [28.0±3.0(stat)±2.8(syst)]×10-4. This result definitively establishes the existence of CP violation in a decay process. © 1999 The American Physical Society.
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- 1999
39. The Role of Crop Simulation Modeling in Managing Fertilizer Use in Maize Production Systems in Northern Ghana
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Dilys S. MacCarthy, Samuel G. K. Adiku, Alpha Y. Kamara, Bright S. Freduah, and Joseph X. Kugbe
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- 2022
- Full Text
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40. Depression, anxiety and PTSD symptoms before and during the COVID-19 pandemic in the UK.
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Young, K. S., Purves, K. L., Hübel, C., Davies, M. R., Thompson, K. N., Bristow, S., Krebs, G., Danese, A., Hirsch, C., Parsons, C. E., Vassos, E., Adey, B. N., Bright, S., Hegemann, L., Lee, Y. T., Kalsi, G., Monssen, D., Mundy, J., Peel, A. J., and Rayner, C.
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POST-traumatic stress disorder ,RETROSPECTIVE studies ,PSYCHOLOGICAL tests ,MENTAL depression ,RESEARCH funding ,QUESTIONNAIRES ,ANXIETY ,COVID-19 pandemic ,LONGITUDINAL method - Abstract
Background: The impact of the coronavirus disease 2019 (COVID-19) pandemic on mental health is still being unravelled. It is important to identify which individuals are at greatest risk of worsening symptoms. This study aimed to examine changes in depression, anxiety and post-traumatic stress disorder (PTSD) symptoms using prospective and retrospective symptom change assessments, and to find and examine the effect of key risk factors. Method: Online questionnaires were administered to 34 465 individuals (aged 16 years or above) in April/May 2020 in the UK, recruited from existing cohorts or via social media. Around one-third (n = 12 718) of included participants had prior diagnoses of depression or anxiety and had completed pre-pandemic mental health assessments (between September 2018 and February 2020), allowing prospective investigation of symptom change. Results: Prospective symptom analyses showed small decreases in depression (PHQ-9: −0.43 points) and anxiety [generalised anxiety disorder scale – 7 items (GAD)-7: −0.33 points] and increases in PTSD (PCL-6: 0.22 points). Conversely, retrospective symptom analyses demonstrated significant large increases (PHQ-9: 2.40; GAD-7 = 1.97), with 55% reported worsening mental health since the beginning of the pandemic on a global change rating. Across both prospective and retrospective measures of symptom change, worsening depression, anxiety and PTSD symptoms were associated with prior mental health diagnoses, female gender, young age and unemployed/student status. Conclusions: We highlight the effect of prior mental health diagnoses on worsening mental health during the pandemic and confirm previously reported sociodemographic risk factors. Discrepancies between prospective and retrospective measures of changes in mental health may be related to recall bias-related underestimation of prior symptom severity. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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41. Variability of Vascular Reactivity in the Retina and Choriocapillaris to Oxygen and Carbon Dioxide Using Optical Coherence Tomography Angiography
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Ashimatey, Bright S., primary, Zhou, Xiao, additional, Chu, Zhongdi, additional, Alluwimi, Muhammed, additional, Wang, Ruikang K., additional, and Kashani, Amir H., additional
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- 2023
- Full Text
- View/download PDF
42. sj-docx-1-jhp-10.1177_00221678231168516 – Supplemental material for Dosing and Therapeutic Conduct in Administration Sessions in Substance-Assisted Psychotherapy: A Systematized Review
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Thal, S. B., Wieberneit, M., Sharbanee, J. M., Skeffington, P. M., Bruno, R., Wenge, T., and Bright, S. J.
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FOS: Psychology ,170199 Psychology not elsewhere classified - Abstract
Supplemental material, sj-docx-1-jhp-10.1177_00221678231168516 for Dosing and Therapeutic Conduct in Administration Sessions in Substance-Assisted Psychotherapy: A Systematized Review by S. B. Thal, M. Wieberneit, J. M. Sharbanee, P. M. Skeffington, R. Bruno, T. Wenge and S. J. Bright in Journal of Humanistic Psychology
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- 2023
- Full Text
- View/download PDF
43. Sensitivity of Maize Yield in Smallholder Systems to Climate Scenarios in Semi-Arid Regions of West Africa: Accounting for Variability in Farm Management Practices
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Freduah, Bright S, MacCarthy, Dilys S, Adam, Myriam, Ly, Mouhamed, Ruane, Alex C, Timpong-Jones, Eric C, Traore, Pierre S, Boote, Kenneth J, Porter, Cheryl, and Adiku, Samuel G. K
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Meteorology And Climatology - Abstract
Climate change is estimated to exacerbate existing challenges faced by smallholder farmers in Sub-Sahara Africa. However, limited studies quantify the extent of variation in climate change impact under these systems at the local scale. The Decision Support System for Agro-technological Transfer (DSSAT) was used to quantify variation in climate change impacts on maize yield under current agricultural practices in semi-arid regions of Senegal (Nioro du Rip) and Ghana (Navrongo and Tamale). Multi-benchmark climate models (Mid-Century, 2040–2069 for two Representative Concentration Pathways, RCP4.5 and RCP8.5), and multiple soil and management information from agronomic surveys were used as input for DSSAT. The average impact of climate scenarios on grain yield among farms ranged between −9% and −39% across sites. Substantial variation in climate response exists across farms in the same farming zone with relative standard deviations from 8% to 117% at Nioro du Rip, 13% to 64% in Navrongo and 9% to 37% in Tamale across climate models. Variations in fertilizer application, planting dates and soil types explained the variation in the impact among farms. This study provides insight into the complexities of the impact of climate scenarios on maize yield and the need for better representation of heterogeneous farming systems for optimized outcomes in adaptation and resilience planning in smallholder systems.
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- 2019
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- View/download PDF
44. T5 Point of care blood eosinophil guided oral prednisolone for COPD exacerbations: a multi-centre double blind randomised controlled trial (The STARR2 trial)
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Ramakrishnan, S, primary, Jeffers, H, additional, Langford-Wiley, B, additional, Davies, J, additional, Mahdi, M, additional, A’Court, C, additional, Binnian, I, additional, Bright, S, additional, Cartwright, S, additional, Fox, R, additional, Russell, REK, additional, and Bafadhel, M, additional
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- 2022
- Full Text
- View/download PDF
45. Productivity of Soybean under Projected Climate Change in a Semi-Arid Region of West Africa: Sensitivity of Current Production System
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MacCarthy, Dilys S., primary, Traore, Pierre S., additional, Freduah, Bright S., additional, Adiku, Samuel G. K., additional, Dodor, Daniel E., additional, and Kumahor, Samuel K., additional
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- 2022
- Full Text
- View/download PDF
46. Point of care blood eosinophil guided oral prednisolone for COPD exacerbations: a multi-centre double blind randomised controlled trial (The STARR2 trial)
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Ramakrishnan, S, primary, Jeffers, H, additional, Langford-Wiley, B, additional, Davies, J, additional, Mahdi, M, additional, A'Court, C, additional, Binnian, I, additional, Bright, S, additional, Cartwright, S, additional, Fox, R, additional, Russell, R E, additional, and Bafadhel, M, additional
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- 2022
- Full Text
- View/download PDF
47. Internet Reagency: The Implications of a Global Science for Collaboration, Productivity, and Gender Inequity in Less Developed Areas
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Miller, B. Paige, Duque, Ricardo, Anderson, Meredith, Ynalvez, Marcus Antonius, Palackal, Antony, Dzorgbo, Dan-Bright S., Mbatia, Paul N., Shrum, Wesley, Hunsinger, Jeremy, editor, Klastrup, Lisbeth, editor, and Allen, Matthew, editor
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- 2010
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48. Novel Technique for Quantifying Retinal Nerve Fiber Bundle Abnormality in the Temporal Raphe
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Ashimatey, Bright S., King, Brett J., Malinovsky, Victor E., and Swanson, William H.
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- 2018
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49. Retinal putative glial alterations: implication for glaucoma care
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Ashimatey, Bright S., King, Brett J., and Swanson, William H.
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- 2018
- Full Text
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50. Why a community engagement framework is fundamental for healthy waterways
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International Conference on Water Sensitive Urban Design (5th : 2007 : Sydney, N.S.W.), Catchlove, R, Lloyd, S, Armstrong, B, Castle, J, and Bright, S
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- 2007
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