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287 results on '"Briggaman, Robert A."'

20. Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils: a preliminary report

Author

Woodley, David T., Zelickson, Alvin S., Briggaman, Robert A., Hamilton, Ted A., Weiss, Jonathan S., Ellis, Charles N., and Voorhees, John J.

Subjects
Tretinoin -- Evaluation, Dermatology -- Research, Skin -- Wrinkles, Skin, Effect of radiation on the -- Drug therapy, Skin Aging, Sunburn -- Complications
Abstract

Photoaging of the skin refers to cumulative damage from sun exposure. There is limited evidence so far that 0.1 percent tretinoin applied directly to the skin can improve the characteristics and appearance of photodamaged skin. In this study, six women (age range, 36 to 55 years) applied tretinoin to one forearm and an inactive placebo cream to the other forearm daily for four months. At the beginning and end of the study, skin biopsies were taken and the structure of the skin was examined using an electron microscope. Specifically, the number of anchoring fibrils in the epidermal-dermal junction were counted; these structures contain the protein collagen. It was theorized that during sun damage, exposure to UV light increases the production of collagenase, the enzyme that breaks down collagen in the skin, and that the collagenase degrades the anchoring fibrils. Tretinoin is believed to inhibit this process, preserving the anchoring fibrils. The anchoring fibrils may literally anchor the layers of skin to one another, straightening out the tiny wrinkles caused by sun damage. Treatment with tretinoin doubled the density of anchoring fibrils as compared with the placebo cream; the increased number of these anchoring fibrils may be responsible for the improved appearance of photoaged skin when treated with tretinoin. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

46. Autoantibodies to Type VII Collagen Recognize Epitopes in a Fibronectin-Like Region of the Noncollagenous (NC1) Domain

Author

Jenison, Mark, Gammon, W. Ray, Padilla, Karen, Hunt, Stephen, Prisayanh, Phillip, Murrell, D��d��e, Jones, Drew, and Briggaman, Robert

Subjects
integumentary system, skin and connective tissue diseases
Abstract

Autoantibodies to type VII collagen are characteristic of the blistering diseases epidermolysis bullosa acquisita and bullous systemic lupus erythematosus (SLE). Blisters in those diseases are due to defective adhesion of the lamina densa subregion of the epithelial basement membrane to the underlying dermis. Previous studies indicating that type VII collagen contributes to lamina densa-dermal adhesion by cross-linking lamina densa and dermal matrix proteins suggests that autoantibodies may contribute to blisters by interfering with type VII collagen function. That hypothesis is supported by previous studies showing autoantibodies from a small number of epidermolysis bullosa acquisita patients recognize proteolytic fragments containing the 145-kD noncollagenous domain of type VII collagen. In this study, we examined reactivity of autoantibodies from a large number of epidermolysis bullosa acquisita and bullous SLE patients with fusion proteins representing most of the noncollagenous domain of type VII collagen and that those regions are homologous to type III repeats of fibronectin. These results suggest autoantibodies binding to fibronectin homology regions within the 145-kD noncollagenous domain may interfere with the adhesion function of type VII collagen and contribute to lamina densa-dermal dysadhesion in epidermolysis bullous acquisita and bullous SLE.

Published
1993
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47. Characterization of ���Neo-Dermis��� Formation Beneath Cultured Human Epidermal Autografts Transplanted on Muscle Fascia

Author

O'Keefe, Edward, Woodley, David, Peterson, Hugh, Meyers, Anthony, Briggaman, Robert, and Herzog, Sandra

Subjects
musculoskeletal diseases, surgical procedures, operative, musculoskeletal system
Abstract

Cultured human keratinocyte autografts were transplanted to burn wounds that had been completely excised down to muscle fascia such that all cutaneous elements were removed from the wounds. Healing autografts were biopsied from days 6-153 in five patients, and the "neo-dermis" beneath the autografts was examined by immunofluorescent staining using antibody probes to connective tissue molecules, by histochemical staining for elastin fibers, and by electron microscopy. We found that the neo-dermis contained most of the major connective tissue elements early in the post-transplantation period. However, regardless of the time examined, there was a paucity of elastin fibers and poor organization of linkin (microthread-like fibers) in the neo-dermis beneath autografts. The perturbations of these connective tissue components in the neo-dermis may play a role in the poor recoil and elastic properties of burn wounds treated with autografts.

Published
1990
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49. Bubble hair

Author

Detwiler, Susan P., primary, Carson, Johnny L., additional, Woosley, John T., additional, Gambling, Todd M., additional, and Briggaman, Robert A., additional

Published
1994
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