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ObjectiveWe analyzed trends in patients' characteristics, outcomes, and waiting times over the last 25 years at our epilepsy surgery center situated in Central Europe to highlight possible areas of improvement in our care for patients with drug-resistant epilepsy. MethodsA total of 704 patients who underwent surgery at the Brno Epilepsy Center were included in the study, 71 of those were children. Patients were separated into three time periods, 1996-2000 (n = 95), 2001-2010 (n = 295) and 2011-2022 (n = 314) based on first evaluation at the center. ResultsThe average duration of epilepsy before surgery in adults remained high over the last 25 years (20.1 years from 1996 to 2000, 21.3 from 2001 to 2010, and 21.3 from 2011 to 2020, P = 0.718). There has been a decrease in rate of surgeries for temporal lobe epilepsy in the most recent time period (67%-70%-52%, P < 0.001). Correspondingly, extratemporal resections have become more frequent with a significant increase in surgeries for focal cortical dysplasia (2%-8%-19%, P < 0.001). For resections, better outcomes (ILAE scores 1a-2) have been achieved in extratemporal lesional (0%-21%-61%, P = 0.01, at least 2-year follow-up) patients. In temporal lesional patients, outcomes remained unchanged (at least 77% success rate). A longer duration of epilepsy predicted a less favorable outcome for resective procedures (P = 0.024) in patients with disease duration of less than 25 years. SignificanceThe spectrum of epilepsy surgery is shifting toward nonlesional and extratemporal cases. While success rates of extratemporal resections at our center are getting better, the average duration of epilepsy before surgical intervention is still very long and is not improving. This underscores the need for stronger collaboration between epileptologists and outpatient neurologists to ensure prompt and effective treatment for patients with drug-resistant epilepsy.

Title: The case study of physiotherapeutical treatment of a patient with diagnosis edema and shock of cervical spinal cord. Summary: The topic of the bachelor thesis is a case interpretation of the patient with edema and shock of cervical spinal cord which happened after a car accident. The aim of this thesis is a comprehensive treatment of the theoretical and practilal knowledge in a patient with the above mentioned diagnosis. The general theoretic part processes anatomy of a spine and a spinal cord. This anatomy is followed by description of the spine and spinal cord injury. Further I deal a clinical picture, pathophysiology of spinal cord injury and subsequent rehabilitation in the theoretical part. The special part includes a case interpretation of the patient with edema and shock of cervical spinal cord and a therapy of this demage. The chosen physiotherapy effect is evaluated in a conclusion. Key words: spinal cord, spinal cord injury, rehabilitation, case study

Objective: Our primary goal was to evaluate our experience with performing intraoperative magnetic resonance imaging (iMRI) in a traditional MRI suite during endoscopic endonasal pituitary adenoma resection. Methods: From March 2008 to February 2013 a single department performed endoscopic endonasal pituitary adenoma resection on 50 patients. Surgical outcomes were compared between the first 25 patients (no iMRI) and the second 25 patients with whom iMRI was used. We evaluated not only the number of total resections in both groups, but also the prolongation of the time of the surgery in the second group. We also evaluated the progression of ophthalmic and endocrinological symptoms in both groups and the rate of complications. Results: The average length of the surgery was prolonged from 205 to 238 minutes (marginally statistically insignificant). We achieved total adenoma resection in seven cases (28%) in the first group and in 16 cases (64%) in the second group (a statistically significant difference). iMRI was successfully performed on all the patients in the second group without any complications related to patient transport or the execution of the imaging. There were no statistically significant differences in diabetes insipidus occurrence, postoperative visual field improvement, or...

Early diagnosis of the failure of endoscopic third ventricolostomy Aim of the study: The aim of the study is to determine the risk of ETV failure based on the presence or absence of radiological indications of third chamber deformation (bowing of the third chamber) on preoperative MR brain scans in patients with obstructive hydrocephalus. Additionally evaluating extend of the bowing, patients age, regression of bowing following successful ETV, etiology, degree of prematurity of newborns, persistence and character of clinical symptoms and other factors. Type of the study: Prospective clinical study. The data set and methodology: Data set comprised 157 patients with obstructive hydrocephalus operated on Neurosurgical clinic of University Hospital Ostrava between January 2008 and December 2016. The follow up duration was at least 3 months. From this cohort we were able to determine effect of bowing on ETV outcome in 135 patients. Of these patients, 70 were adults, 27 were children between 7 months and 16 years of age and 38 were infants under 6 months. From 38 infants under 6 months were 22 severe premature newborns, 9 moderately premature newborns and 7 mildly premature newborns. The extend of the bowing was determine in the range 3 - 14 mm. Results: ETV was noted as successful in 84 cases (62%). Statistical...

OBJECTIVES: The S100B protein subgroup is a thermolabile acidic calcium-binding protein. S100B protein was first described in the central nervous system. Destruction of the nerve tissue results in S100B protein release from astrocytic glial cells and elevation of its levels in the cerebrospinal fluid. If the blood-brain barrier is also damaged, S100B gets into the systemic circulation and elevated blood levels of S100B are detected. Higher S100B serum levels in patients with head injury are predictive of possible development of secondary brain injury and the extent of permanent injury to the CNS. MATHERIAL AND METHODS: The authors present their results obtained in the group of 39 children aged 0 (newborns) to 17 years with isolated craniocerebral injury. RESULTS: Our group included 39 children aged 0-17 years. Excellent results (GOS - Glasgow outcome scale 4-5) were observed in 33 patients already at the time of transfer from our ICU to the neurological department. There was no death and the poor outcome group included only 6 children. Second GOS evaluation was performed 6 months later, when 36 children were in the GOS 4-5 group and only 3 children in the GOS 2-3 group. CONCLUSIONS: Due to high variability in S100B protein serum levels in children depending on age and gender, no correlation between...