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1. Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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2. COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

Author

Bay, Pierre, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Turpin, Matthieu, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Roux, Damien, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Levy, David, Burrel, Sonia, Mayaux, Julien, Kimmoun, Antoine, Hartard, Cédric, Pène, Frédéric, Rozenberg, Flore, Gaudry, Stéphane, Brichler, Ségolène, Guillon, Antoine, Handala, Lynda, Tamion, Fabienne, Moisan, Alice, Daix, Thomas, Hantz, Sébastien, Delamaire, Flora, Thibault, Vincent, Souweine, Bertrand, Henquell, Cecile, Picard, Lucile, Botterel, Françoise, Rodriguez, Christophe, Dessap, Armand Mekontso, Pawlotsky, Jean-Michel, Fourati, Slim, and de Prost, Nicolas

Published
2024
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4. Treatment with bulevirtide in HIV-infected patients with chronic hepatitis D: ANRS HD EP01 BuleDelta and compassionate cohort

Author

Raffi, François, Alric, Laurent, Miailhes, Patrick, Tran, Albert, Stern, Christiane, Causse, Xavier, Tripon, Simona, Riachi, Ghassan, Chazouillères, Olivier, Abergel, Armando, d’Alteroche, Louis, Gournay, Jérôme, Lagadic, Garance, Carrieri, Patrizia, Brichler, Ségolène, Siguier, Martin, Krause, Jessica, Foucher, Juliette, Ben Ali, Souad, Meszaros, Magdalena, Varaut, Anne, Canva, Valérie, de Lédinghen, Victor, Fougerou-Leurent, Claire, Le Pabic, Estelle, Pol, Stanislas, Alfaiate, Dulce, Lacombe, Karine, Hilleret, Marie-Noëlle, Lascoux-Combe, Caroline, Minello, Anne, Billaud, Eric, Rosa, Isabelle, Gervais, Anne, Ratziu, Vlad, Ganne, Nathalie, Pageaux, Georges-Philippe, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Chas, Julie, Jezequel, Caroline, Métivier, Sophie, Dumortier, Jérôme, Arpurt, Jean-Pierre, Asselah, Tarik, Roche, Bruno, Le Gruyer, Antonia, Valantin, Marc-Antoine, Scholtès, Caroline, Gordien, Emmanuel, Tual, Christelle, Kortebi, Amel, Coulibaly, Fatoumata, Rosenthal, Eric, Subic-Levrero, Miroslava, Roulot, Dominique, and Zoulim, Fabien

Published
2024
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5. Effect of Peg-IFN on the viral kinetics of patients with HDV infection treated with bulevirtide

Author

El Messaoudi, Selma, Brichler, Ségolène, Fougerou-Leurent, Claire, Gordien, Emmanuel, Gerber, Athenaïs, Kortebi, Amal, Lagadic, Garance, Subic-Levrero, Miroslava, Metivier, Sophie, Pol, Stanislas, Minello, Anne, Ratziu, Vlad, Leroy, Vincent, Mathurin, Philippe, Alric, Laurent, Coulibaly, Fatoumata, Pawlotsky, Jean-Michel, Zoulim, Fabien, de Lédinghen, Victor, and Guedj, Jérémie

Published
2024
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7. High Diagnostic Value of Transient Elastography for Advanced Fibrosis and Cirrhosis in Patients With Chronic Hepatitis Delta

Author

Loustaud-Ratti, Véronique, Silvain, Christine, Benali, Souad, Ingiliz, Patrick, Gouton, Martial, Guyader, Dominique, Roche, Bruno, Chazouillères, Olivier, Asselah, Tarik, Ziol, Marianne, Roulot, Dominique, Brichler, Ségolène, Layese, Richard, D’alteroche, Louis, Ganne-Carrie, Nathalie, Stern, Christiane, Saviano, Antonio, Leroy, Vincent, Roudot-Thoraval, Françoise, and De Ledinghen, Victor

Published
2024
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8. Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron variants BA.2, BA.5 and BQ.1.1 in critically ill patients with COVID-19: a prospective, multicenter cohort study

Author

de Prost, Nicolas, Audureau, Etienne, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Bay, Pierre, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, Voiriot, Guillaume, Morand-Joubert, Laurence, Jochmans, Sébastien, Pitsch, Aurélia, Meireles, Sylvie, Contou, Damien, Henry, Amandine, Joseph, Adrien, Chaix, Marie-Laure, Uhel, Fabrice, Descamps, Diane, Emery, Malo, Garcia-Sanchez, Claudio, Luyt, Charles-Edouard, Marot, Stéphane, Pène, Frédéric, Lhonneur, Anne-Sophie, Gaudry, Stéphane, Brichler, Ségolène, Picard, Lucile, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2023
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9. Feedback from Medical and Biology Students on Distance Learning: Focus on a Useful Interactive Software, Wooclap®

Author

Marin, Julie, Brichler, Ségolène, Lecuyer, Hervé, Carbonnelle, Etienne, and Lescat, Mathilde

Abstract

The coronavirus disease 2019 epidemic has prompted all universities to completely change their teaching in a very rapid way around the world. In France, most of the university courses for the year 2020 had to be delivered at distance. This can be an opportunity for some to rethink the place and the form of distance learning (DL). We present here the feedback of students about DL, who answered a questionnaire about classes they followed between October and December 2020. In addition, we evaluated the use and utility of an audience response system promoting interaction. Our results showed that overall the organization and internet connections allowed DL to run smoothly. Interestingly, all students were in favor of the development of a mixed solution, with distant lectures and face-to-face practical lessons. Finally, the use of interactive software such as Wooclap® has proven to be easy to use and to develop for all lessons.

Published
2021
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11. The diagnostic cascade for patients with hepatitis delta infection in France, 2018–2022: A cross‐sectional study.

Author

Brichler, Ségolène, Trimoulet, Pascale, Roque‐Afonso, Anne‐Marie, Izopet, Jacques, Thibault, Vincent, Roudot‐Thoraval, Françoise, and Chevaliez, Stéphane

Subjects
*HEPATITIS associated antigen, *HEPATITIS D, *CHRONIC active hepatitis, *VIRAL hepatitis, *MEDICAL screening, *HEPATITIS C
Abstract

Background and Aims: Chronic hepatitis D infection is the most severe form of viral hepatitis and can rapidly progress to cirrhosis or hepatocellular carcinoma. Despite recommendations for systematic screening of hepatitis B surface antigen (HBsAg)‐positive individuals, data from real‐world studies have reported a low frequency of hepatitis D (or delta) virus (HDV) screening. Our cross‐sectional analysis evaluated the diagnostic cascade for hepatitis D infection in tertiary centres and described the characteristics of HDV‐positive patients. Methods: A total of 6772 individuals who tested HBsAg positive for the first time between 2018 and 2022 were retrospectively included. Demographic, clinical and laboratory data were analysed. Results: A total of 5748 HBsAg‐positive individuals (84.9%) were screened for HDV infection. The screening rate varied from 63% to 97% according to the screening strategy used in the centres including or not HDV reflex testing. The prevalence of HDV infection was 6.3%. HDV RNA levels were determined in 285 of the 364 (78.3%) HDV antibody screening‐positive patients, and 167 (58.6%) had active HDV infection. 66.8% were males, with a mean age of 44.9 years. A total of 97.5% were born abroad, and 92.9% were HBeAg negative. At the time of diagnosis, HDV RNA levels were 6.0 Log UI/mL; 60.1% had alanine aminotransferase >40 U/L, and 56.3% had significant fibrosis (≥F2), including 41.6% with cirrhosis. The most common genotype was HDV‐1 (75.4%). Coinfections were not uncommon: 7.4% were HIV positive, and 15.0% were HCV antibody positive. Conclusions: The present study highlights the need for increased screening and monitoring of HDV infection. Reflex testing helps to identify HDV‐infected individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Comparison of Dual Monoclonal Antibody Therapies for COVID-19 Evolution: A Multicentric Retrospective Study †.

Author

Zafilaza, Karen, Bellet, Jonathan, Truffot, Aurélie, Foulongne, Vincent, Onambele, Manuela Mireille, Salmona, Maud, Vellas, Camille, Périllaud-Dubois, Claire, Mirand, Audrey, André-Garnier, Elisabeth, Alidjinou, Enagnon Kazali, Brichler, Ségolène, Fenaux, Honorine, Bouvier-Alias, Magali, Hartard, Cédric, Dorival, Céline, Carrat, Fabrice, Marcelin, Anne-Geneviève, Stefic, Karl, and Soulie, Cathia

Subjects
COVID-19, GENE therapy, COVID-19 treatment, SARS-CoV-2, MONOCLONAL antibodies
Abstract

Background: Neutralizing antibodies targeting the SARS-CoV-2 Spike protein reduce COVID-19-related risk of hospitalization, particularly in high-risk individuals. The COCOPREV-R study aimed to evaluate and compare clinical outcomes in high-risk SARS-CoV-2 patients treated with dual monoclonal antibody therapies and to identify associated virological factors. Methods: The COCOPREV-R study retrospectively collected real-world data from high-risk patients receiving Bamlanivimab/Etesevimab or Casirivimab/Imdevimab dual monoclonal antibody therapies (22 February 2021 to 15 June 2021). Results: The study included 1004 patients with COVID-19, of whom 691 received Bamlanivimab/Etesevimab and 313 received Casirivimab/Imdevimab. The alpha variant represented 90.1% of those for whom data were available. The risk of hospitalization within 30 days was lower with Bamlanivimab/Etesevimab (12.7%, CI 95% [9.9–16.3%]) compared to Casirivimab/Imdevimab (28.4%, CI 95% [22.7–35.1%) (p < 0.001). The 30-day mortality rates were comparable between both groups (p = 0.982). Analysis of SARS-CoV-2 PCR negativity showed no difference between the two treatment groups (95.2% [93.0–96.9%] and 93.5% [89.1–96.6%] until day 30, p = 0.851 for Bamlanivimab/Etesevimab and Casirivimab/Imdevimab, respectively). Among persistently positive samples with available sequencing results (n = 43), Spike protein changes occurred only in Bamlanivimab/Etesevimab (42.9%) vs. Casirivimab/Imdevimab (0.0%) groups. Q493R (25.0%) and E484K (12.5%) were the most common mutations selected by Bamlanivimab/Etesevimab in follow-up samples. Other factors (immunodepression, comorbidities, and age) did not appear to be associated with the occurrence of Spike protein mutations. Conclusions: A higher rate of hospitalization was seen with Casirivimab/Imdevimab (RONAPREVE®) in comparison with Bamlanivimab/Etesevimab treatment, but with the emergence of Spike mutations only in the Bamlanivimab/Etesevimab group. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19

Author

de Prost, Nicolas, Audureau, Etienne, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, de Montmollin, Nina, Voiriot, Guillaume, Morand-Joubert, Laurence, Joseph, Adrien, Chaix, Marie-Laure, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Luyt, Charles-Edouard, Burrel, Sonia, Mayaux, Julien, Marot, Stéphane, Roux, Damien, Descamps, Diane, Meireles, Sylvie, Pène, Frédéric, Rozenberg, Flore, Contou, Damien, Henry, Amandine, Gaudry, Stéphane, Brichler, Ségolène, Timsit, Jean-François, Kimmoun, Antoine, Hartard, Cédric, Jandeaux, Louise-Marie, Fafi-Kremer, Samira, Gabarre, Paul, Emery, Malo, Garcia-Sanchez, Claudio, Jochmans, Sébastien, Pitsch, Aurélia, Annane, Djillali, Azoulay, Elie, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2022
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14. Author Correction: Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19

Author

de Prost, Nicolas, Audureau, Etienne, Heming, Nicholas, Gault, Elyanne, Pham, Tài, Chaghouri, Amal, de Montmollin, Nina, Voiriot, Guillaume, Morand-Joubert, Laurence, Joseph, Adrien, Chaix, Marie-Laure, Préau, Sébastien, Favory, Raphaël, Guigon, Aurélie, Luyt, Charles-Edouard, Burrel, Sonia, Mayaux, Julien, Marot, Stéphane, Roux, Damien, Descamps, Diane, Meireles, Sylvie, Pène, Frédéric, Rozenberg, Flore, Contou, Damien, Henry, Amandine, Gaudry, Stéphane, Brichler, Ségolène, Timsit, Jean-François, Kimmoun, Antoine, Hartard, Cédric, Jandeaux, Louise-Marie, Fafi-Kremer, Samira, Gabarre, Paul, Emery, Malo, Garcia-Sanchez, Claudio, Jochmans, Sébastien, Pitsch, Aurélia, Annane, Djillali, Azoulay, Elie, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, and Fourati, Slim

Published
2022
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15. Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients

Author

Vauloup-Fellous, Christelle, Maylin, Sarah, Périllaud-Dubois, Claire, Brichler, Ségolène, Alloui, Chakib, Gordien, Emmanuel, Rameix-Welti, Marie-Anne, Gault, Elyanne, Moreau, Frédérique, Fourati, Slim, Challine, Dominique, Pawlotsky, Jean-Michel, Houhou-Fidouh, Nadhira, Damond, Florence, Mackiewicz, Vincent, Charpentier, Charlotte, Méritet, Jean-François, Rozenberg, Flore, Podglajen, Isabelle, Marot, Stéphane, Petit, Heloïse, Burrel, Sonia, Akhavan, Sepideh, Leruez-Ville, Marianne, Avettand-Fenoel, Véronique, Fourgeaud, Jacques, Guilleminot, Tiffany, Gardiennet, Elise, Bonacorsi, Stéphane, Carol, Agnès, Carcelain, Guislaine, Villemonteix, Juliette, Boukli, Narjis, Gozlan, Joël, Morand-Joubert, Laurence, Legoff, Jérome, Delaugerre, Constance, Chaix, Marie-Laure, Roque-Afonso, Ana-Maria, Dortet, Laurent, Naas, Thierry, Ronat, Jean-Baptiste, Lepape, Samuel, Marcelin, Anne-Geneviève, and Descamps, Diane

Published
2021
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23. Outcomes of Omicron sub-lineages BA.1.1 and BA.2 infection compared with the sub-lineage BA.1 infection in emergency departments' patients

Author

Bouzid, Donia, primary, Kapfer, Thomas, additional, Marot, Stéphane, additional, Ing, Vittiaroat, additional, Ferré, Valentine Marie, additional, Chauvin, Anthony, additional, Le Goff, Jérôme, additional, Ellouze, Sami, additional, Salmona, Maud, additional, Hermand, Christelle, additional, Bourg, Arthur, additional, Schnuriger, Aurélie, additional, Fémy, Florent, additional, Van Tinh, Méryl Nguyen, additional, Brichler, Ségolène, additional, Veyer, David, additional, Le Borgne, Pierrick, additional, Fafi-Kremer, Samira, additional, L'Honneur, Anne Sophie, additional, Augustin, Clément, additional, Simon, Tabassome, additional, Cachanado, Marine, additional, and Freund, Yonathan, additional

Published
2023
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28. HIV-1 infection in South Kivu (Democratic Republic of Congo): high genotypic resistance to antiretrovirals.

Author

Duhant, Alexandra, Kusinza, Byabene, Tantet, Claire, Bisimwa, Basimane, Gare, Mathilde, Masemo, Bihehe, Alloui, Chakib, Ntakwinjan, Mukanire, Mechai, Frédéric, Le, Minh Patrick, Gerber, Athenaïs, Muhigirwa, Balthazar, Peytavin, Gilles, Gordien, Emmanuel, Brichler, Ségolène, Mukwege, Mukengere, and Gal, Frédéric Le

Subjects
GENOTYPES, HIV, PATIENT compliance, ANTIRETROVIRAL agents, RALTEGRAVIR, VIRAL load
Abstract

Background Panzi General Reference Hospital (HGR Panzi) in the Democratic Republic of Congo follows a large number of patients living with HIV-1 (PLWHIV). Although antiretrovirals (ARVs) are available, HIV-1 viral load (HIV-VL) measurement has only been implemented in the hospital since 2018. No data on ARV resistance levels and ARV dosage in plasma have yet been published for this region. We determined the prevalence of virological failure due to ARV resistance amongst patients and assessed the degree of genotypic resistance of the viral strains. Methods We performed an HIV-VL test and determined dosage of ARVs on samples collected from 205 PLWHIV at HGR Panzi between 2017 and 2018, including 13 ARV-naive patients. Genotypic resistance testing was performed on all samples with detectable HIV-VLs, and interpreted with the Agence Nationale de Recherches sur le Sida (ANRS) 2018 algorithm. Results Baseline resistance to NNRTIs was found in 2 of the 13 treatment-naive individuals (15%). ARV dosage was non-optimal for 44/192 of treated patients (22.9%), with an HIV-VL ≥1000 IU/mL for 40/192 (20.8%) of them. In particular, treatment-experienced viruses presented resistance to at least one NRTI (52.5%), to at least one NNRTIs (70%) or to at least one PIs (15%). Finally, two samples contained viruses with resistance polymorphism in the integrase gene. Conclusions The high level of resistance to ARVs observed during this study, mainly due to treatment compliance default, fully justifies the implementation of means for closer patient monitoring. The provision of VL tests and therapeutic education management tools in a PLWHIV follow-up remains an absolute necessity to best adapt the current treatment lines in this region. [ABSTRACT FROM AUTHOR]

Published
2023
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29. SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study

Author

Fourati, Slim, primary, Audureau, Etienne, additional, Arrestier, Romain, additional, Marot, Stéphane, additional, Dubois, Claire, additional, Voiriot, Guillaume, additional, Luyt, Charles-Edouard, additional, Urbina, Tomas, additional, Mayaux, Julien, additional, Roque-Afonso, Anne-Marie, additional, Pham, Tài, additional, Landraud, Luce, additional, Visseaux, Benoit, additional, Roux, Damien, additional, Bellaiche, Raphael, additional, L’honneur, Anne-Sophie, additional, Ait Hamou, Zakaria, additional, Brichler, Ségolène, additional, Gaudry, Stéphane, additional, Salmona, Maud, additional, Clere-Jehl, Raphaël, additional, Azoulay, Elie, additional, Morand-Joubert, Laurence, additional, Marcelin, Anne-Geneviève, additional, Chaix, Marie-Laure, additional, Descamps, Diane, additional, Mekontso Dessap, Armand, additional, Rodriguez, Christophe, additional, Pawlotsky, Jean-Michel, additional, and de Prost, Nicolas, additional

Published
2022
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32. Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients

Author

Yazdanpanah, Yazdan, DIALLO, Alpha, PAUL, Christelle, MERCIER, Noémie, LE MESTRE, Soizic, PETROV‐SANCHEZ, Ventzislava, ANDREJAK, Claire, CHIROUZE, Catherine, MALVY, Denis, DEPLANQUE, Dominique, DUBOS, François, ROSSIGNOL, Patrick, ETIENNE, Manuel, ROSSIGNOL, Bénédicte, LEVY‐MARCHAL, Claire, GILG, Morgane, GIGANTE, Tristan, Marine, BELUZE, HULOT, Jean‐Sebastien, CHAIR, Anissa, KHALIL, Antoine, VISSEAUX, Benoit, COUFFIGNAL, Camille, ROY, Carine, LAOUÉNAN, Cédric, DA SILVEIRA, Charlene, TARDIVON, Coralie, BACHELET, Delphine, DESCAMPS, Diane, MENTRÉ, France, BOMPART, François, LESCURE, François‐Xavier, PEYTAVIN, Gilles, GORENNE, Isabelle, HOFFMANN, Isabelle, GHOSN, Jade, Christophe LUCET, Jean, TIMSIT, Jean‐François, MULLAERT, Jimmy, BHAVSAR, Krishna, BOUADMA, Lila, TAGHERSET, Lysa, TELLIER, Marie‐Capucine, DEBRAY, Marie‐Pierre, ESPOSITO‐FARESE, Marina, SCHNEIDER, Marion, LE, Minh, ETTALHAOUI, Nadia, SI MOHAMMED, Nassima, GAULT, Nathalie, PEIFFER‐SMADJA, Nathan, KEFIF, Ouifiya, ELOY, Philippine, LE HINGRAT, Quentin, KALI, Sabrina, LARIBI, Samira, TUBIANA, Sarah, TRIOUX, Théo, DUVAL, Xavier, VANEL, Noémie, PICONE, Olivier, BASMACI, Romain, ANGOULVANT, François, KAGUELIDOU, Florentia, PAGES, Justine, VEISLINGER, Aurélie, TUAL, Christelle, PAPADOPOULOS, Aurélie, ESPEROU, Hélène, JAAFOURA, Salma, COUFFIN‐CADIERGUES, Sandrine, COELHO, Alexandra, HOCTIN, Alexandre, DIOUF, Alphonsine, MAMBERT, Marina, GAYMARD, Alexandre, LINA, Bruno, ROSA‐CALATRAVA, Manuel, BOUSCAMBERT, Maude, TERRIER, Olivier, MEZIANE, Amina, DORIVAL, Céline, BENKEROU, Dehbia, TÉOULÉ, François, LINGAS, Guillaume, LE NAGARD, Hervé, GUEDJ, Jérémie, NEANT, Nadège, ABEL, Laurent, KHAN, Coralie, DESVALLÉE, Mathilde, WIEDEMANN, Aurélie, LEVY, Yves, MOUQUET, Hugo, BEHILILL, Sylvie, van der WERF, Sylvie, ENOUF, Vincent, SEMAILLE, Caroline, dORTENZIO, Eric, CERVANTES‐GONZALEZ, Minerva, PUÉCHAL, Oriane, NORET, Marion, RORIZ, Mélanie, RISPAL, Patrick, REDL, Sarah, LEFEBVRE, Laurent, GRANIER, Pascal, MAULIN, Laurence, JOSEPH, Cédric, MOYET, Julien, LION‐DAOLIO, Sylvie, MAHIEU, Rafael, DUCANCELLE, Alexandra, DUBEE, Vincent, SALLABERRY, Stéphane, MANUEL, Aldric, MACHEDA, Gabriel, MAILLET, Mylène, CHANZY, Bruno, GAGNARD, Jean‐Charles, GIORDANO, Guillermo, MOUTON PERROT, Clara, PESTRE, Vincent, FICKO, Cécile, GOMINET, Marie, BOUSQUET, Aurore, VAUCHY, Charline, BOUILLER, Kévin, PAGADOY, Maïder, MARTY‐QUINTERNET, Solène, LEPILLER, Quentin, LE BRIS, Cyril, THILL, Benoit, CASANOVA, Marie‐Laure, LE FALHER, Georges, OZIOL, Eric, CORDEL, Hugues, DOURNON, Nathalie, BOUCHAUD, Olivier, BRICHLER, Ségolène, NGUYEN, Duc, BELLECAVE, Pantxika, CICCONE, Camille, LAFON, Marie‐Edith, GREFFE, Ségolène, BOUISSE, Camille, SEDILLOT, Nicholas, BOUHOUR, Damien, CHASSIN, Camille, LHER, Erwan, ANSART, Séverine, TROMEUR, Cécile, GUELLEC, Dewi, MERCKX, Antoine, DJOSSOU, Felix, PEIGNE, Vincent, PIEROBON, Carola, CARRET, Marie‐Christine, JEGO, Florence, ISNARD, Margaux, AUCHABIE, Johann, COURTOIS, Roxane, LESENS, Olivier, MARTINOT, Martin, LACOSTE, Marie, ELHARRAR, Brigitte, GARRAIT, Valérie, DELACROIX, Isabelle, MAITRE, Thomas, Baptiste ASSIE, Jean, NYAMANKOLLY, Elsa, Xavier CATHERINE, François, BLOT, Mathieu, MAHY, Sophie, BUISSON, Marielle, PIROTH, Lionel, GUILLOTIN, Florence, DE ROUGEMONT, Alexis, CAMPANA, Valentine, PASQUIER, Jérémie, CABIE, André, BESSIS, Simon, EPAULARD, Olivier, TERZI, Nicolas, PAYEN, Jean‐François, BOUILLET, Laurence, HAMIDFAR, Rebecca, Le MARECHAL, Marion, MACHADO, Moïse, BARRELET, Audrey, BEDOSSA, Alexandra, COLIN, Gwenhaël, DECOURS, Romain, GUIMARD, Thomas, GOUJARD, Cécile, JAUREGUIBERRY, Stéphane, CHERET, Antoine, Sophie RESSEGUIER, Anne, POISSY, Julien, MATHIEU, Daniel, NSEIR, Saad, ENGELMANN, Ilka, REMY, Martine, VUOTTO, Fanny, GACHET, Benoit, FAURE, Karine, BOYER‐BESSEYRE, Marielle, Enagnon, Kazali, LAMBERT, Marc, SCHERPEREEL, Arnaud, FRY, Stéphanie, YELNIK, Cécile, BITKER, Laurent, MEZIDI, Mehdi, YONIS, Hodane, BENECH, Nicolas, PERPOINT, Thomas, CONRAD, Anne, ICARD, Vinca, VALETTE, Martine, THIBERVILLE, Simon‐Djamel, REBAUDET, Stanislas, DUSSOL, Bertrand, DIAMANTIS, Sylvain, CHAKVEATZE, Catherine, FLATEAU, Clara, DINOT, Vincent, GACI, Rostane, OUAMARA, Nadia, ILLES, Hajnal‐Gabriela, GERBAUD MORLAES, Louis, DIMET, Jérôme, LE MOING, Vincent, PANSU, Nathalie, LE BIHAN, Clément, MONTES, Brigitte, Sophie BOUREAU, Anne, ALLAVENA, Clotilde, BOUCHEZ, Sabelline, GUERY, Romain, LE TURNIER, Paul, MEAR‐PASSARD, Cécile, FERRE, Virginie, RAPP, Christophe, DEMONCHY, Elisa, MICHELANGELLI, Céline, RISSO, Karine, LOUBET, Paul, LAVIGNE, Jean‐Phillippe, DE MONTMOLLIN, Etienne, PATRIER, Juliette, Henri WICKY, Paul, LE FEVRE, Lucie, JACQUET, Pierre, BORIE, Raphael, DOSSIER, Antoine, LUTON, Dominique, ISERNIA, Valentina, LE GAC, Sylvie, AZOULAY, Cécile, CARLIER, Nicolas, LUONG, Liem, LACHATRE, Marie, LAUNAY, Odile, KERROUMI, Younes, MEYSSONNIER, Vanina, DIEHL, Jean‐Luc, HULOT, Jean‐Sébastien, CHOLLEY, Bernard, ARLET, Jean‐Benoît, SANCHEZ, Olivier, MANDA, Victoria, AZEMAR, Laurène, CASTOR‐ALEXANDRE, Guylaine, LACOMBE, Karine, CHIARABINI, Thibault, LEFEBVRE, Bénédicte, MORAND‐JOUBERT, Laurence, FOFANA, Djeneba, SCHNURIGER, Aurélie, DE CASTRO, Nathalie, DELAUGERRE, Constance, CHAIX, Marie‐Laure, CHAS, Julie, GABORIEAU, Valérie, LE COUSTUMIER, Eve, PICARD, Walter, ZABBE, Jean‐Benoît, PEELMAN, Florent, SOUM, Edouard, AUMAÎTRE, Hugues, CURLIER, Elodie, OUISSA, Rachida, FABRE, Isabelle, RAMMAERT, Blandine, SAIDANI, Nadia, BANI‐SADR, Firouzé, HENTZIEN, Maxime, NGUYEN, Yohan, ROMARU, Juliette, DIDIER, Kévin, ENDERLE, Isabelle, THIBAULT, Vincent, LAINE, Fabrice, LESOUHAITIER, Matthieu, REVEST, Matthieu, TATTEVIN, Pierre, PLANTIER, Jean‐Christophe, LEMEE, Véronique, FERRAND DEVOUGE, Eglantine, ALEXANDRE, Kévin, ARTAUD‐MACCARI, Elise, ALLOU, Nathalie, LAGRANGE, Marie, JABOT, Julien, ROZE, Benoît, BREGEAUD, Delphine, AIT TAMLIHAT, Younes, HACHEMI, Ali, SALVATOR, Hélène, FOURN, Erwan, ZUCMAN, David, DELAVEUVE, Eric, JAUD‐FISCHER, Coline, DUNAND, Paul, BISSUEL, François, DELAVIGNE, Karen, PIEL‐JULIAN, Marie, DELOBEL, Pierre, SARTON, Benjamine, RAFIQ, Marie, MARTIN‐BLONDEL, Guillaume, GUILLEMINAULT, Laurent, MURRIS, Marlène, SOMMET, Agnès, SENNEVILLE, Eric, ROBINEAU, Olivier, MEYBECK, Agnès, GAROT, Denis, PLANTIER, Laurent, GISSOT, Valérie, MARLET, Julien, STEFIC, Karl, GAUDY‐GRAFFIN, Catherine, BARIN, Francis, LEMAIGNEN, Adrien, CORVAISIER, Grégory, LARIVIERE, Delphine, LANGELOT‐RICHARD, Marie, BOTELHO‐NEVERS, Elisabeth, GAGNEUX‐BRUNON, Amandine, TROUILLON, Tiffany, BOURLET, Thomas, PILLET, Sylvie, POZZETTO, Bruno, KIMMOUM, Antoine, LEVY, Bruno, MATTEI, Mathieu, GOEHRINGER, François, RABAUD, Christian, BEVILACQUA, Sibylle, LEFEVRE, Benjamin, GUILLAUMOT, Anne, VENARD, Véronique, JEULIN, Hélène, SCHVOERER, Evelyne, HARTARD, Cédric, CARAUX PAZ, Pauline, RICHIER, Laurent, EL SANHARAWI, Mohamed, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, ANRS France Recherche Nord & sud Sida-hiv hépatites, France REcherche Nord & sud Sida-hiv Hépatites (FRENSH), CHU Amiens-Picardie, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, French COVID cohort study group, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), CHU Rouen, Normandie Université (NU), and The Alliance for International Medical Action [Dakar, Sénégal] (ONG ALIMA)

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, Adolescent, prospective cohort, SARS‐CoV‐2, Cohort Studies, Young Adult, coronavirus disease 2019, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Risk Factors, Virology, Internal medicine, Diabetes mellitus, emerging infection diseases, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Research Articles, Aged, Aged, 80 and over, SARS-CoV-2, Proportional hazards model, business.industry, Hazard ratio, Age Factors, COVID-19, Middle Aged, Viral Load, medicine.disease, Obesity, Confidence interval, Hospitalization, Infectious Diseases, Female, 030211 gastroenterology & hepatology, France, business, Viral load, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

Little is known on the association between clinical factors and coronavirus disease 2019 (COVID‐19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID‐19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, according to mortality up to Day 60 after admission. For the analysis of risk factors of survival, analyses assessing associations between mortality and demographic characteristics or comorbidities were performed using a Cox regression model. Between January 24 and March 15, 2020, 246 patients with reverse‐transcriptase polymerase chain reactions virologically confirmed COVID‐19 were enrolled. In multivariate analysis, mortality at Day 60 (n = 42 patients, 17.1% [95% confidence interval, 12.6–22.4]) was associated with older age (adjusted hazard ratio [aHR] for age ≥ 65 years: 5.22 [2.56–10.63, p, Highlights Older age, male gender, chronic pulmonary disease (not asthma), obesity, and diabetes were associated with mortality in COVID‐19 hospitalized patients. Viral load at admission decreased with the time since symptom onset, with an association with mortality adjusted on clinical risk factors.

Published
2020
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33. Humoral response to mRNA anti–COVID-19 vaccines BNT162b2 and mRNA-1273 in patients with chronic lymphocytic leukemia

Author

Bagacean, Cristina, Letestu, Rémi, Al-Nawakil, Chadi, Brichler, Ségolène, Lévy, Vincent, Sritharan, Nanthara, Delmer, Alain, Dartigeas, Caroline, Leblond, Véronique, Roos-Weil, Damien, Tomowiak, Cécile, Merabet, Fatiha, Béné, Marie C., Clavert, Aline, Chaoui, Driss, Genet, Philippe, Guieze, Romain, Laribi, Kamel, Drénou, Bernard, Willems, Lise, Puppinck, Christian, Legendre, Hugo, Troussard, Xavier, Malartre, Stéphanie, Cymbalista, Florence, and Michallet, Anne-Sophie

Published
2022
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34. WED-410 Sustained virological response after treatment with Bulevirtide in HDV patients. Data from the french multicenter real-life cohort

Author

de Lédinghen, Victor, Lacombe, Karine, Pol, Stanislas, Alric, Laurent, Lascoux-Combe, Caroline, Alfaiate, Dulce, Hilleret, Marie-Noëlle, Ganne-Carrié, Nathalie, Gournay, Jérôme, Loustaud-Ratti, Veronique, Subic-Levrero, Miroslava, Coulibaly, Fatoumata, Pabic, Estelle Le, Tual, Christelle, Brichler, Segolene, and Zoulim, Fabien

Published
2024
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35. FRI-406 Real world outcomes of hepatitis delta patients with mild or moderate fibrosis

Author

Lens, Sabela, Kamal, Habiba, d'Almeida, Arno Furquim, Brichler, Segolene, Papatheodoridi, Margarita, Palom, Adriana, Casado-Martin, Marta, Bourgeois, Stefan, Diago, Moises, Lindahl, Karin, Conde, Marta Hernández, Rodríguez, Manuel, Moreno, Christophe, Giráldez-Gallego, Alvaro, Garcia-Samaniego, Francisco Javier, Sersté, Thomas, Cabezas, Joaquin, Delwaide, JeAn, Buti, Maria, Papatheodoridis, George, Roulot, Dominique, Vanwolleghem, Thomas, de Lédinghen, Victor, Aleman, Soo, and Panero, José Luis Calleja

Published
2024
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36. OS-034 Safety and efficacy of REP 2139-Mg in hepatitis D patients with advanced liver disease: an international compassionate use program

Author

Stern, Christiane, Bourliere, Marc, Loustaud-Ratti, Veronique, Bardou-Jacquet, Edouard, Alric, Laurent, Colombain, Lea, Meszaros, Magdalena, Metivier, Sophie, Mathurin, Philippe, Yurdaydin, Cihan, Jachs, Mathias, Reiberger, Thomas, Brancaccio, Giuseppina, Yardeni, David, Etzion, Ohad, Neumann-Haefelin, Christoph, Douglas, Mark, Poulin, Sebastien, Benali, Souad, Bedoya, José Ursic, Metin, Olga, Bazinet, Michel, Schwarz, Michael, Gaeta, Giovanni Battista, Vitale, Alessandro, Svicher, Valentina, Cillo, Umberto, Brichler, Segolene, Gordien, Emmanuel, Chevaliez, Stéphane, and Vaillant, Andrew

Published
2024
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37. Sa1638 SAFETY AND EFFICACY OF REP 2139-MG AGAINST HBV / HDV COINFECTION WITH ADVANCED LIVER DISEASE

Author

Stern, Christiane, Bourliere, Marc, Loustaud-Ratti, Veronique, Ali, Souad Ben, Bardou-Jacquet, Edouard, Alric, Laurent, Colombain, Lea, Meszaros, Magdalena, Bedoya, Jose Ursic, Metivier, Sophie, Mathurin, Philippe, Jachs, Mathias, Reiberger, Thomas, Neumann-Haefelin, Christoph, Yurdaydin, Cihan, Brancaccio, Giuseppina, Poulin, Sébastien, Bazinet, Michel, Albuquerque, Miguel, Paradis, Valerie, Schwarz, Michael, Testoni, Barbara, Zoulim, Fabien, Mackiewicz, Vincent, Brichler, Ségolène, Gordien, Emmanuel, and Vaillant, Andrew

Published
2024
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38. Reassessing the performance of the “step-by-step” approach to febrile infants aged 90 days and younger in the context of the COVID-19 pandemic: a multicentric retrospective study

Author

Rybak, Alexis, primary, Aupiais, Camille, additional, Cotillon, Marie, additional, Basmaci, Romain, additional, de Pontual, Loïc, additional, Bonacorsi, Stéphane, additional, Mariani, Patricia, additional, Landraud, Luce, additional, Brichler, Ségolène, additional, Poilane, Isabelle, additional, Ouldali, Naïm, additional, and Titomanlio, Luigi, additional

Published
2022
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40. Humoral Response to mRNA Vaccines BNT162b2 and mRNA-1273 COVID-19 in Chronic Lymphocytic Leukemia Patients

Author

Bagacean, Cristina, primary, Letestu, Rémi, additional, Al Nawakil, Chadi, additional, Brichler, Ségolène, additional, Lévy, Vincent, additional, Sritharan, Nanthara, additional, Delmer, Alain, additional, Dartigeas, Caroline, additional, Leblond, Véronique, additional, Roos-Weil, Damien, additional, Béné, Marie C, additional, Clavert, Aline, additional, Chaoui, Driss, additional, Genet, Philippe, additional, Guieze, Romain, additional, Laribi, Kamel, additional, Touileb, Yamina, additional, Drenou, Bernard, additional, Willems, Lise, additional, Tomowiak, Cécile, additional, Merabet, Fatiha, additional, Puppink, Christian, additional, Legendre, Hugo, additional, Troussard, Xavier, additional, Malartre, Stéphanie, additional, Cymbalista, Florence, additional, and Michallet, Anne-Sophie, additional

Published
2021
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41. The Delta SARS-CoV-2 variant has a higher viral load than the Beta and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients

Author

Teyssou, Elisa, primary, Delagrèverie, Héloise, additional, Visseaux, Benoit, additional, Lambert-Niclot, Sidonie, additional, Brichler, Ségolène, additional, Ferre, Valentine, additional, Marot, Stéphane, additional, Jary, Aude, additional, Todesco, Eve, additional, Schnuriger, Aurélie, additional, Ghidaoui, Emna, additional, Abdi, Basma, additional, Akhavan, Sepideh, additional, Houhou-Fidouh, Nadhira, additional, Charpentier, Charlotte, additional, Morand-Joubert, Laurence, additional, Boutolleau, David, additional, Descamps, Diane, additional, Calvez, Vincent, additional, Marcelin, Anne Geneviève, additional, and Soulie, Cathia, additional

Published
2021
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43. Early assessment of diffusion and possible expansion of SARS-CoV-2 Lineage 20I/501Y.V1 (B.1.1.7, variant of concern 202012/01) in France, January to March 2021

Author

Gaymard, Alexandre, Bosetti, Paolo, Feri, Adeline, Destras, Gregory, Enouf, Vincent, Andronico, Alessio, Burrel, Sonia, Behillil, Sylvie, Sauvage, Claire, Bal, Antonin, Morfin, Florence, Van Der Werf, Sylvie, Josset, Laurence, Blanquart, François, Coignard, Bruno, Cauchemez, Simon, Lina, Bruno, Gault, Elyanne, Moreau, Frédérique, Brichler, Ségolène, Delagrèverie, Héloïse, Descamps, Diane, Charpentier, Charlotte, Rozenberg, Flore, L'Honneur, Anne-Sophie, Veyer, David, Bélec, Laurent, Fourati, Slim, Rodriguez, Christophe, Pawlotsky, Jean-Michel, Fourgeaud, Jacques, Abid, Hanène, Roque-Afonso, Anne-Marie, Fenaux, Honorine, Jary, Aude, Marot, Stéphane, Salmona, Maud, Chaix, Marie-Laure, Morand-Joubert, Laurence, Schnuriger, Aurélie, Juillet, Stéphanie Marque, Bargain, Pauline, Poggi, Cécile, Chollet, Lionel, Guillaume, Clémence, Guinard, Jérôme, Vallet, Sophie, Pilorgé, Léa, Schvoerer, Evelyne, Hartard, Cédric, Castelain, Sandrine, François, Catherine, Ducancelle, Alexandra, Lefeuvre, Caroline, Lepiller, Quentin, Marty-Quinternet, Solène, Bellecave, Pantxika, Tumiotto, Camille, Dina, Julia, Le Gouil, Meriadeg, Henquell, Cécile, Mirand, Audrey, Césaire, Raymond, de Rougemont, Alexis, Auvray, Christelle, Larrat, Sylvie, Némoz, Benjamin, Tinez, Claire, Guigon, Aurélie, Hantz, Sébastien, Rogez, Sylvie, Dos Santos, Georges, Perez, Pascale, Jost, Christelle, Montes, Brigitte, Foulongne, Vincent, Imbert, Berthe-Marie, Bressollette, Céline, Giordanengo, Valérie, Gonfrier, Géraldine, Garcia, Magali, Lévêque, Nicolas, Brodard, Véronique, Moret, Hélène, Thibault, Vincent, Maillard, Anne, Jaffar-Bandjee, Marie-Christine, Gueudin, Marie, Plantier, Jean-Christophe, Pozzetto, Bruno, Pillet, Sylvie, Fafi-Kremer, Samira, Solis, Morgane, Izopet, Jacques, Trémeaux, Pauline, Stefic, Karl, Handala, Lynda, Billaud, Geneviève, Frobert, Emilie, Mérens, Audrey, Bigaillon, Christine, Desroches, Marine, Thepenier, Cédric, Janvier, Frédéric, Otto, Marie-Pierre, Roquebert, Bénédicte, Haïm-Boukobza, Stéphanie, Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR - laboratoire associé), Institut des Agents Infectieux [Lyon] (IAI), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL), Virpath-Grippe, de l'émergence au contrôle -- Virpath-Influenza, from emergence to control (Virpath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Direction des maladies infectieuses - Infectious Diseases Division [Saint-Maurice], Santé publique France - French National Public Health Agency [Saint-Maurice, France], Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Laboratoire de Virologie [CHU Amiens], CHU Amiens-Picardie, ANRS - Maladies infectieuses émergentes (ANRS - MIE), Institut National de la Santé et de la Recherche Médicale (INSERM), We acknowledge financial support from Santé publique France (the French national public health agency), the French Ministry of health (Grant COVIDseq), the Consortium for the surveillance and research on emerging pathogens via microbial genomics (EMERGEN) coordinated by Santé publique France and ANRS Maladies Infectieuses Emergentes, the Investissement d’Avenir programme, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases programme (grant ANR-10-LABX-62-IBEID), the European Union’s Horizon 2020 research and in-novation programme under grants 101003589 (RECOVER). This work has been supported by the laboratories belonging to the ColVHB network*., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Centre National de Référence des Virus des Infections Respiratoires (dont la Grippe) [Lyon] (CNR), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Gestionnaire, Hal Sorbonne Université, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Rapid European COVID-19 Emergency Response research - RECOVER - - H2020-SC1-PHE-CORONAVIRUS-20202020-02-14 - 2022-02-13 - 101003589 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris)

Subjects
Author's Correction, Paris, medicine.medical_specialty, 2019-20 coronavirus outbreak, Lineage (genetic), Coronavirus disease 2019 (COVID-19), Epidemiology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viral infections, [SDV]Life Sciences [q-bio], Context (language use), Biology, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, Humans, MESH: COVID-19, MESH: SARS-CoV-2, 030212 general & internal medicine, 030304 developmental biology, COVID, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Humans, SARS-CoV-2, MESH: Paris, Public Health, Environmental and Occupational Health, COVID-19, [SDV] Life Sciences [q-bio], MESH: France, 20I/501Y.V1, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, surveillance, France, mutation, Rapid Communication, Demography
Abstract

International audience; The emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling assumptions.

Published
2021
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45. Early virological response in six patients with hepatitis D virus infection and compensated cirrhosis treated with Bulevirtide in real‐life

Author

Asselah, Tarik, primary, Loureiro, Dimitri, additional, Le Gal, Fréderic, additional, Narguet, Stéphanie, additional, Brichler, Ségolène, additional, Bouton, Valérie, additional, Abazid, Malek, additional, Boyer, Nathalie, additional, Giuly, Nathalie, additional, Gerber, Athenais, additional, Tout, Issam, additional, Maylin, Sarah, additional, Bed, Cheikh M., additional, Marcellin, Patrick, additional, Castelnau, Corinne, additional, Gordien, Emmanuel, additional, and Mansouri, Abdellah, additional

Published
2021
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46. SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study

Author

Lachassinne, Eric, primary, de Pontual, Loïc, additional, Caseris, Marion, additional, Lorrot, Mathie, additional, Guilluy, Carole, additional, Naud, Aurélie, additional, Dommergues, Marie-Aliette, additional, Pinquier, Didier, additional, Wannepain, Evelyne, additional, Hausherr, Elisabeth, additional, Jung, Camille, additional, Gajdos, Vincent, additional, Cohen, Robert, additional, Zahar, Jean-Ralph, additional, Brichler, Ségolène, additional, Basmaci, Romain, additional, Boelle, Pierre-Yves, additional, Bloch-Queyrat, Coralie, additional, Aupiais, Camille, additional, Charbonnier, Lorelei, additional, Chosidow, Anais, additional, Hentgen, Véronique, additional, Lescano, Oscar, additional, Mestre, Nathalie, additional, Pinto Cardoso, Gaelle, additional, Masson, Roselyne, additional, Rabehi, Bahia, additional, Romain, Anne-Sophie, additional, Vié le Sage, François, additional, and Vuillaume, Xavier, additional

Published
2021
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47. Prior surveillance and antiviral treatment improve the prognosis of HCC developed in HBV patients in the West

Author

Allaire, Manon, primary, El Hajj, Weam, additional, Brichler, Ségolène, additional, Diallo, Kadiatou, additional, Fanica, Daniela, additional, Blaise, Lorraine, additional, Nkontchou, Gisèle, additional, Grando, Véronique, additional, Arbadi, Fatima, additional, Nahon, Pierre, additional, Ziol, Marianne, additional, Nault, Jean-Charles, additional, and Ganne-Carrié, Nathalie, additional

Published
2021
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