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1. Thrombolytiques

Author

Bennis, Y., primary, Bricca, G., additional, Laporte, S., additional, and Mismetti, P., additional

Published
2020
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5. Les auteurs

Author

Bellien, J., primary, Cracowski, J.-L., additional, Ambrosi, P., additional, Andréjak, M., additional, Angoulvant, D., additional, Atkinson, C., additional, Barau, C., additional, Bedouch, P., additional, Bejan-Angoulvant, T., additional, Bellien, J., additional, Benevent, J., additional, Berreni, A., additional, Berthat, V., additional, Bourgeois, A.-L., additional, Bousquet, P., additional, Boutouyrie, P., additional, Bricca†, G., additional, Chaumais, M.-C., additional, Despas, F., additional, Donazzolo, Y., additional, Faure, S., additional, Funck-Bretano, C., additional, Gueyffier, F., additional, Ghaleh, B., additional, Lamoureux, F., additional, Laporte, S., additional, Laviolle, B., additional, Legeay, S., additional, Lotiron, C., additional, Michel, V., additional, Mismetti, P., additional, Molimard, M., additional, Monassier, L., additional, Montani, D., additional, Muller, B., additional, Pathak, A., additional, Picard, N., additional, Plotkine, M., additional, Pons, S., additional, Ribuot, C., additional, Richard, V., additional, Roustit, M., additional, Senard, J.-M., additional, Ternant, D., additional, and Timour, Q., additional

Published
2016
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10. Le réseau des Centres de Ressources Biologiques Humains

Author

Barilero, I., Becquemont, L., Bertoye, P.-H., Bonnavita, M.-J., Bricca, G., Clément, B., Deleuze, J.-F., Deplanque, D., Desbois, I., Deugnier, Y., Di Donato, J.-H., Grimaud, J.-A., Haiech, J., Lassale, C., Laurent-Vo, J.-M., Libersa, C., Paintaud, G., Pinard-Duchamp, D., Plouin, P.-F., Postaire, E., Ravoire, S., Réchaussat, L., Reynier, J.-C., Vella, P., Clément, Bruno, Grimaud, Jean-Alexis, Deleuze, Jean-François, and Postaire, Eric

Published
2005
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11. The Human Biological Resource Centres Network

Author

Barilero, I., Becquemont, L., Bertoye, P.-H., Bonnavita, M.-J., Bricca, G., Clément, B., Deleuze, J.-F., Deplanque, D., Desbois, I., Deugnier, Y., Di Donato, J.-H., Grimaud, J.-A., Haiech, J., Lassale, C., Laurent-Vo, J.-M., Libersa, C., Paintaud, G., Pinard-Duchamp, D., Plouin, P.-F., Postaire, E., Ravoire, S., Réchaussat, L., Reynier, J.-C., Vella, P., Clément, Bruno, Grimaud, Jean-Alexis, Deleuze, Jean-François, and Postaire, Eric

Published
2005
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16. Role of imidazoline receptors in cardiovascular regulation

Author

Dontenwill, M., Tibirica, E., Greney, H., Bennai, F., Feldman, J., Stutzmann, J., Bricca, G., Belcourt, A., and Bousquet, P.

Subjects
Rilmenidine -- Physiological aspects, Cardiovascular system, Hypertension -- Drug therapy, Health
Abstract

The involvement of nonadrenergic imidazoline specific receptors in the central control of the vasomotor tone and in the mechanism of action of drugs bearing an imidazoline structure, or analogs, is now well documented. Imidazoline-specific binding sites were found in many tissues and species. Moreover, until now, it is only in the brainstem that such binding sites are associated with a function: the hypotensive effect of imidazoline-like drugs. Rilmenidine, which is an oxazoline structurally related to the reference imidazolines, exerts a central hypotensive effect of central origin involving imidazoline receptors. The selectivity of rilmenidine for the imidazoline receptors compared to [[alpha].sub.2]-adrenergic receptors could explain the low incidence of sedative side effects observed with this antihypertensive drug. A specific anti-imidazoline radioimmunoassay allowed us to detect the presence of an immunoreactive imidazoline-like substance in human sera. High levels of this immunoreactive substance are associated with high blood pressure in 20--30% of the hypertensive patients. This observation indicates that high levels of this immunoreactive substance in the serum can be associated with some kinds of primary hypertension. The cause-and-effect relation between these 2 phenomena has not yet been determined. This substance is in process of purification; it could be a candidate to be an endogenous ligand of the imidazoline receptors.

Published
1994

17. Can we identify response markers to antihypertensive drugs? First results from the Ideal Trial

Author

Gueyffier, F., Subtil, F., Bejan-Angoulvant, T., Zerbib, Y., Baguet, J. P., Boivin, J. M., Mercier, A., Leftheriotis, G., Gagnol, J. P., Fauvel, J. P., Giraud, C., Bricca, G., Maucort-Boulch, Delphine, Erpeldinger, S., Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV]Life Sciences [q-bio]
Published
2015

18. Renal denervation for treating hypertension: experience at the University Hospital in Lyon

Author

Courand, P. Y., Dauphin, R., Rouviere, O., Paget, V., Khettab, F., Bergerot, Cyrille, Harbaoui, B., Bricca, G., Fauvel, J. P., Lantelme, P., Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)

Subjects
Male, [SDV]Life Sciences [q-bio], Hypertension/blood/complications/*surgery, Body Mass Index, Risk Factors, Blood Pressure Monitoring, Natriuretic Peptide, Ambulatory, Humans, Prospective Studies, Aged, University, Left Ventricular/etiology, Renal Artery/innervation/*surgery, Hypertrophy, Middle Aged, Denervation/methods, Hospitals, Treatment Outcome, Kidney/innervation, Female, France, Brain/blood, Peptide Fragments/blood, Biomarkers/blood, Follow-Up Studies
Abstract

International audience; AIM: We report the first experience of Lyon's university hospital regarding renal denervation to treat patients with resistant essential hypertension. PATIENTS AND METHODS: Over a one-year period, 17 patients were treated (12 men, 5 women) with renal denervation. Baseline characteristics were as follows: age 56.5+/-11.5 years, BMI 33+/-5kg/m(2) and ambulatory blood pressure 157+/-16/87+/-13mmHg with 4.2+/-1.5 anti-hypertensive treatment. RESULTS: We did not observe intra-operative or early complications. After a median follow-up of 3 months and with the same anti-hypertensive treatment, office systolic blood pressure (SBP) and diastolic blood pressure (DBP) decrease respectively of 20+/-15 (P\textless0.001) and 10+/-13mmHg (P=0.014) (n=17). After six months of follow-up, ambulatory blood pressure (ABPM) decrease of 17.5+/-14.9mmHg (P=0.027) for SBP and of 10.5+/-9.6mmHg (P=0.029) for DBP (n=6). Among these patients, five of them were controlled (ABPM inferior to 130/80mmHg) and electrical left ventricular hypertrophy indexes decreased: R wave in aVL lead of 4+/-3mm (P=0.031), Sokolow index of 3+/-3mm (P=0.205), Cornell voltage criterion of 9+/-7mm (P=0.027) and Cornell product of 1310+/-1104 (P=0.027). CONCLUSION: Our results are in accordance with data from other centers. On average blood pressure decreases significantly but important inter individual variations are observed. The procedure seems safe.

Published
2014

19. 3D.03

Author

Courand, P.Y., primary, Fay, H., additional, Harbaoui, B., additional, Khettab, F., additional, Fauvel, J.P., additional, Bricca, G., additional, Milon, H., additional, and Lantelme, P., additional

Published
2015
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20. 8D.07

Author

Nehme, A., primary, Zibara, K., additional, Cerutti, C., additional, and Bricca, G., additional

Published
2015
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21. 1A.03

Author

Cerutti, C., primary, Paultre, C.Z., additional, Gustin, M.P., additional, Lohez, O., additional, Feugier, P., additional, Li, J.Y., additional, and Bricca, G., additional

Published
2015
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22. PP.30.16

Author

Lantelme, P., primary, Harbaoui, B., additional, Khettab, F., additional, Bricca, G., additional, Milon, H., additional, Fauvel, J.P., additional, and Courand, P.Y., additional

Published
2015
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24. Recommandation: Prise en charge de l’hypertension artérielle de l’adulte

Author

Blacher, J., primary, Halimi, J.-M., additional, Hanon, O., additional, Mourad, J.-J., additional, Pathak, A., additional, Schnebert, B., additional, Girerd, X., additional, Azizi, M., additional, Baguet, J.-P., additional, Bedel, J.-L., additional, Benetos, A., additional, Boivin, J.-M., additional, Bricca, G., additional, Chamontin, B., additional, Denolle, T., additional, Dupont, E., additional, Fauvel, J.-P., additional, Fayolle, P., additional, Ghasarossian, C., additional, Giral, P., additional, Gury, C., additional, Herpin, D., additional, Jeunemaitre, X., additional, Juilliere, Y., additional, Kretz, S., additional, Lacolley, P., additional, Laurent, S., additional, Lemaire, A., additional, Lemogne, C., additional, Lequeux, B., additional, London, G., additional, Mallion, J.-M., additional, Mounier-Vehier, C., additional, Nguyen, J.-P., additional, Pernin, D., additional, Pinto, E., additional, Protogerou, A., additional, Ribstein, J., additional, Saillard, D., additional, Sosner, P., additional, Targowla Scandolo, N., additional, Thuillez, C., additional, Vaisse, B., additional, Villeneuve, F., additional, and Yannoutsos, A., additional

Published
2013
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26. Imidazoline receptors, non-adrenergic idazoxan binding sites and alpha 2-adrenoceptors in the human central nervous system

Author

De Keyser, Jacques, De Vos, Hilde, Bricca, G., De Backer, J.p., Bousquet, Pascal, Vauquelin, G., and Gerontology

Subjects
Male, Binding Sites, Cell Membrane/metabolism, alpha-2/analysis/*metabolism, receptors, in vitro, Dioxanes/*metabolism, Clonidine/metabolism, Middle Age, Radioligand Assay, nervous system, Idazoxan, kinetics, Organ Specificity, Adrenergic, 80 and over, Autoradiography, Pituitary Gland/*metabolism, Comparative Study, Female, Brain/*metabolism, Drug/analysis/*metabolism, Spinal Cord/*metabolism, Aged, Human
Abstract

Both [3H]clonidine and [3H]idazoxan bind to alpha 2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristics of [3H]clonidine and [3H]idazoxan to these sites by radioligand binding experiments on ultra-thin slices and homogenates of human striatum. A good correlation was found between the effect of different ions on the binding characteristics of [3H]clonidine and [3H]idazoxan, and the affinities of most competing drugs. However, clonidine and rilmenidine displayed a 100- and 10-fold lower affinity, respectively, for the idazoxan binding sites than for the imidazoline receptors. Autoradiography with [3H]clonidine showed that high densities of imidazoline receptors were present in the striatum, pallidum, gyrus dentatus of the hippocampus, amygdala, and substantia nigra. Moderate densities were found throughout the cerebral cortex, thalamus and several brainstem nuclei including the nucleus olivarius inferior. Low densities were seen in the cerebellum, spinal cord and pituitary gland. As for the non-adrenergic sites labelled by [3H]idazoxan, the imidazoline receptors can be found in all major brain areas examined. However, there are some striking differences between the concentrations of imidazoline receptors and non-adrenergic idazoxan binding sites in certain brain regions. To reconcile distribution and pharmacologic data, we propose that imidazoline receptors and non-adrenergic idazoxan binding sites represent different proteins or protein complexes and that at least in the nucleus reticularis lateralis and the striatum, imidazoline receptors and non-adrenergic idazoxan binding sites may be physically associated. The regional distribution of alpha 2 adrenoceptors within the human CNS was determined by quantitative autoradiography with [3H]RX821002. The highest densities of alpha 2 adrenoceptors were found in the cerebral and cerebellar cortex, and certain regions in the medulla oblongata (floor of the IV ventricle, reticular formation, hypoglossal nucleus and nucleus olivarius inferior). No alpha 2 adrenoceptors were detected in the pituitary gland. There exists no relationship between the distribution pattern of imidazoline receptors and alpha 2 adrenoceptors, indicating that these binding sites are independent from each other.

Published
1994

33. 138: T-Cadherin Expression in Cardiac Allograft Vasculopathy after Human Heart Transplantation

Author

Roussoulieres, A., primary, Collot-Teixeira, S., additional, Morser, K., additional, Chalabreysse, L., additional, McDermott-Roe, C., additional, Cerutti, C., additional, Guzman, A., additional, Michel, J.-B., additional, Boissonnat, P., additional, Sebbag, L., additional, Thivolet-Bejui, F., additional, Bricca, G., additional, and McGregor, J., additional

Published
2009
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38. Le réseau des Centres de Ressources Biologiques Humains

Author

Clément, Bruno, primary, Grimaud, Jean-Alexis, additional, Deleuze, Jean-François, additional, Postaire, Eric, additional, Barilero, I., additional, Becquemont, L., additional, Bertoye, P.-H., additional, Bonnavita, M.-J., additional, Bricca, G., additional, Clément, B., additional, Deleuze, J.-F., additional, Deplanque, D., additional, Desbois, I., additional, Deugnier, Y., additional, Di Donato, J.-H., additional, Grimaud, J.-A., additional, Haiech, J., additional, Lassale, C., additional, Laurent-Vo, J.-M., additional, Libersa, C., additional, Paintaud, G., additional, Pinard-Duchamp, D., additional, Plouin, P.-F., additional, Postaire, E., additional, Ravoire, S., additional, Réchaussat, L., additional, Reynier, J.-C., additional, and Vella, P., additional

Published
2005
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39. The Human Biological Resource Centres Network

Author

Clément, Bruno, primary, Grimaud, Jean-Alexis, additional, Deleuze, Jean-François, additional, Postaire, Eric, additional, Barilero, I., additional, Becquemont, L., additional, Bertoye, P.-H., additional, Bonnavita, M.-J., additional, Bricca, G., additional, Clément, B., additional, Deleuze, J.-F., additional, Deplanque, D., additional, Desbois, I., additional, Deugnier, Y., additional, Di Donato, J.-H., additional, Grimaud, J.-A., additional, Haiech, J., additional, Lassale, C., additional, Laurent-Vo, J.-M., additional, Libersa, C., additional, Paintaud, G., additional, Pinard-Duchamp, D., additional, Plouin, P.-F., additional, Postaire, E., additional, Ravoire, S., additional, Réchaussat, L., additional, Reynier, J.-C., additional, and Vella, P., additional

Published
2005
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