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1. The outcome-based iCAN! / theyCAN! feedback paradigm differentiates strong and weak learning outcomes, learner diversity, and the learning outcomes of each learner: A shift to metacognitive assessment

Author

Dimoliatis Ioannis D K, Zerdes Ioannis, Zampeta Athanasia, Tziortzioti Zoi, Briasoulis Evangelos, and Souglakos Ioannis

Subjects
ican!, theycan!, outcome / competency based education, formative / summative assessment / feedback / examination, metacognition, teaching, learning, oncology, greece, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Can learning outcomes be transformed in useful tools revealing strong and weak learning outcomes, learners, teachers; reporting student self-assessment overestimation; informing formative feedback and summative examinations?

Published
2019
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2. SLCO1B3 screening in colorectal cancer patients using High-Resolution Melting Analysis method and immunohistochemistry

Author

Lampri Evangeli, Sainis Ioannis, Kounnis Valentinos, Mitselou Antigony, Ioachim Elli, Hatzimichael Eleftheria, Galani Vasiliki, and Briasoulis Evangelos

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Personalized medicine has made some major advances in colorectal cancer, but new biomarkers still remain a hot issue as an emerging tool with potential prognostic and therapeutic potential. We investigated for SLCO1B3 gene alterations and protein expression in colorectal cancer, using the novel high-resolution melting analysis technique and immunohistochemistry. Formalin-fixed paraffin-embedded tumor samples from 30 colorectal cancer patients were used. The screening for gene alterations was done by high-resolution melting analysis for all exons of SLCO1B3 gene. Organic anion-transporting polypeptide 1B3 protein expression was assessed by immunohistochemistry using the monoclonal mouse MDQ antibody. High level of polymorphism was observed in the SLCO1B3 gene. We identified three previously reported polymorphisms in exons 7, 12, and 14, 699G>A, 1557A>G, and 1833G>A, respectively. In the exon 5, one variant seems to correspond to an as yet unknown SLCO family member. The immunohistochemical study revealed that organic anion-transporting polypeptide 1B3 was expressed in 27/30 samples. Of great interest, the three samples, which were immunohistochemically negative, all appeared to accommodate mutations which lead to either early stop codons or other conformations of the tertiary protein structures affecting the antibody-epitope binding. The results of this study are of much interest as high-resolution melting analysis proved to be a reliable and rapid genotyping/scanning method for mutation detection of SLCO1B3 gene.

Published
2017
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3. Clinicopathologic study of E-cadherin/beta-catenin complex, and topoisomerase-II in a series of 71 liposarcoma cases

Author

Gogou Pinelopi, Pakos Emilios, Batistatou Anna, Panelos Ioannis, Briasoulis Evangelos, Stefanou Dimitrios, Apostolikas Nikoforos, and Tsekeris Periclis

Subjects
liposarcomas, E-cadherin, b-catenin, topoisomerase II alpha, prognosis, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To investigate the expression of E-cadherin, beta-catenin and topoisomerase-II alpha and examine their clinical relevance in liposarcomas. Materials and methods The expression of E-cadherin, beta-catenin and topoisomerase II alpha was examined immunohistochemically on formalin-fixed paraffin-embedded tissue specimens from 71 patients who underwent surgical treatment for liposarcomas of the extremities or the retroperitoneum in two major cancer reference centres between 1990 and 2000. Detailed medical notes were available for all patients who were followed for median 82 months (range 5 to 215 months). Obtained expression data were weighted against clinical and pathology parameters of clinical relevance. Results Patients were mostly male (59%), median age was 56 years for the liposarcomas of the extremities and 60 years for the retroperitoneal liposarcomas. The tumours were of diverse histology, grade and size (median diameters 7 and 17 cm for tumours of the extremities and retroperitoneum respectively). Expression of β-catenin protein was weakly detected in 15 cases (21.1%). Similarly weak expression of topoisomerase II-alpha was detected in 14 (19.7%) cases of which only two had more than 20% of tumor cells stained positive. E-cadherin was not detected in the studied cohort of liposarcomas. We did not detect associations between the expression of the above proteins by liposarcoma cells and clinical outcome. Conclusions Liposarcomas do not express E-cadherin, which matches the absence of epithelioid differentiation in this sarcoma subtype, and have low topoisomerase II-alpha expression, which justifies to some extend their resistance to anthracycline-based chemotherapy.

Published
2012
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5. Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the pelvis

Author

Karavasilis Vasileios, Panelos Ioannis, Capizzello Antonio, Tolis Christos, Bai Maria, Batistatou Anna, Tsekeris Pericles, Briasoulis Evangelos, Katsanos Konstantinos H, Christodoulou Dimitrios, and Tsianos Epameinondas V

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis. Methods Patients with pelvic tumours referred for radical radiotherapy who consented participation in this trial, were randomly assigned to receive daily amifostine (A) (subcutaneously, 500 mg flat dose) before radiotherapy or radiotherapy alone (R). Sigmoidoscopy and blinded biopsies were scheduled to conduct prior to initiation and following completion of radiotherapy and again 6 to 9 months later. Radiation colitis was assessed by clinical, endoscopic and histolopathological criteria. Results A total 44 patients were enrolled in this trial, the majority with rectal (20 patients) and cervical cancer (12 patients) and were assigned 23 in R arm and 21 in the A arm. In total 119 sigmoidoscopies were performed and 18 patients (18/44, 40.9%) were diagnosed with radiation colitis (15 grade 1 and 2, and 3 grade 3 and 4). Of them, 6 patients belonged to the A group (6/21, 28.6%) and 12 to the R group (12/23, 52.2%). Acute and grade IV radiation colitis was only developed in four patients (17.4%) in the R group. Amifostine side effects were mild. Amifostine treated patients were less likely to develop histologically detectable mucosal lesions, which indicate protection from acute mucosal injury. Conclusions Amifostine given subcutaneously can lower the risk of acute severe radiation colitis in patients who receive radical radiotherapy to pelvic tumors.

Published
2010
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6. A randomized phase II study of carboplatin plus pegylated liposomal doxorubicin versus carboplatin plus paclitaxel in platinum sensitive ovarian cancer patients: a Hellenic Cooperative Oncology Group study

Author

Briasoulis Evangelos, Samantas Epaminondas, Makatsoris Thomas, Timotheadou Eleni, Kosmidis Paris, Kalofonos Haralabos P, Fountzilas George, Bamias Aristotelis, Papadimitriou Christos, Aravantinos Gerasimos, Linardou Helena, Bafaloukos Dimitrios, Christodoulou Christos, Papakostas Pavlos, Pectasides Dimitrios, and Dimopoulos Athanasios M

Subjects
Medicine
Abstract

Abstract Background Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin and pegylated liposomal doxorubicin (LD) with carboplatin and paclitaxel (CP) in this setting. Methods Patients with histologically confirmed recurrent OC, at the time of or more than 6 months after platinum-based chemotherapy, were randomized to six cycles of CP (carboplatin AUC5 + paclitaxel 175 mg/m2, d1q21) or CLD (carboplatin AUC5 + pegylated LD 45 mg/m2, d1q28). Results A total of 189 eligible patients (CP 96, CLD 93), with a median age of 63 years, median Performance Status (PS) 0 and a median platinum free interval (PFI) of 16.5 months, entered the study. Discontinuation due to toxicity was higher in the CP patients (13.5% versus 3%, P = 0.016). The overall response rate was similar: CP 58% versus CLD 51%, P = 0.309 (Complete Response; CR 34% versus 23%) and there was no statistical difference in time-to-progression (TTP) or overall survival (OS; TTP 10.8 months CP versus 11.8 CLD, P = 0.904; OS 29.4 months CP versus 24.7 CLD, P = 0.454). No toxic deaths were recorded. Neutropenia was the most commonly seen severe toxicity (CP 30% versus CLD 35%). More frequent in CLD were severe thrombocytopenia (11% versus 2%, P = 0.016), skin toxicity and Palmar-plantar erythrodysesthesia (PPE) grade 1-2 (38% versus 9%, P< 0.001), while grade 3 neurotoxicity and alopecia were higher in CP (7% versus 0%, P = 0.029, 20% versus 5%, P = 0.003). PS and PFI were independent prognostic factors for TTP and OS. Conclusions The combination of pegylated LD with carboplatin is effective, showing less neurotoxicity and alopecia than paclitaxel-carboplatin. It thus warrants a further phase III evaluation as an alternative treatment option for platinum-sensitive OC patients. Trial Registration Australian New Zealand Clinical Trials Registry: ACTRN12609000436279

Published
2010
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7. Potential value of PTEN in predicting cetuximab response in colorectal cancer: An exploratory study

Author

Koukouma Alona, Gikonti Ioanna, Galanidi Eleni, Bai Maria, Bobos Mattheos, Xanthakis Ioannis, Samantas Epaminontas, Kostopoulos Ioannis, Papamichael Dimitrios, Skarlos Dimosthenis V, Vrettou Eleni, Briasoulis Evangelos, Razis Evangelia, Kafiri Georgia, Papakostas Pavlos, Kalogeras Konstantine T, Kosmidis Paris, and Fountzilas George

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The epidermal growth factor receptor (EGFR) is over-expressed in 70–75% of colorectal adenocarcinomas (CRC). The anti-EGFR monoclonal antibody cetuximab has been approved for the treatment of metastatic CRC, however tumor response to cetuximab has not been found to be associated with EGFR over-expression by immunohistochemistry (IHC). The aim of this study was to explore EGFR and the downstream effector phosphatase and tensin homologue deleted on chromosome 10 (PTEN) as potential predictors of response to cetuximab. Methods CRC patients treated with cetuximab by the Hellenic Cooperative Oncology group, whose formalin-fixed paraffin-embedded tumor tissue was available, were included. Tissue was tested for EGFR and PTEN by IHC and fluorescence in situ hybridization (FISH). Results Eighty-eight patients were identified and 72 were included based on the availability of tissue blocks with adequate material for analysis on them. All patients, except one, received cetuximab in combination with chemotherapy. Median follow-up was 53 months from diagnosis and 17 months from cetuximab initiation. At the time of the analysis 53% of the patients had died. Best response was complete response in one and partial response in 23 patients. In 16 patients disease stabilized. Lack of PTEN gene amplification was associated with more responses to cetuximab and longer time to progression (p = 0.042). Conclusion PTEN could be one of the molecular determinants of cetuximab response. Due to the heterogeneity of the population and the retrospective nature of the study, our results are hypothesis generating and should be approached with caution. Further prospective studies are needed to validate this finding.

Published
2008
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8. Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1

Author

Kalofonos Haralambos, Kitsou Evangelia, Tsanou Elena, Briasoulis Evangelos, Malamou-Mitsi Vasiliki, Karavasilis Vasilis, Fountzilas George, Fotsis Theodore, and Pavlidis Nicholas

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge on the biology of these tumors and identify potential therapeutic targets. Methods Paraffin embedded archival material from 81 patients diagnosed with CUP was used. Tumor histology was adenocarcinoma (77%), undifferentiated carcinoma (18%) and squamous cell carcinoma (5%). The tissue expression of CD34, VEGF and TSP-1 was assessed immunohistochemically by use of specific monoclonal antibodies and was analyzed against clinicopathological data. Results VEGF expression was detected in all cases and was strong in 83%. Stromal expression of TSP-1 was seen in 80% of cases and was strong in 20%. The expression of both proteins was not associated with any clinical or pathological parameters. Tumor MVD was higher in tumors classified as unfavorable compared to more favorable and was positively associated with VEGF and negatively with TSP-1. Conclusion Angiogenesis is very active and expression of VEGF is almost universal in cancers of unknown primary. These findings support the clinical investigation of VEGF targeted therapy in this clinical setting.

Published
2005
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9. Addition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial

Author

Dimopoulos, Meletios A, Richardson, Paul G, Bahlis, Nizar J, Grosicki, Sebastian, Cavo, Michele, Beksaç, Meral, Legieć, Wojciech, Liberati, Anna M, Goldschmidt, Hartmut, Belch, Andrew, Magen, Hila, Larocca, Alessandra, Laubach, Jacob P, Petrucci, Maria T, Reece, Donna, White, Darrell, Mateos, María-Victoria, Špička, Ivan, Lazaroiu, Mihaela, Berdeja, Jesús, Kaufman, Jonathan L, Jou, Ying-Ming, Ganetsky, Alex, Popa McKiver, Mihaela, Lonial, Sagar, Weisel, Katja, Sandhu, Irwindeep, Podhorecka, Monika, Palumbo, Antonio, Shacham-Abulafia, Adi, Vaxman, Iuliana, Shpilberg, Ofer, Besemer, Britta, Martelli, Maurizio, Foà, Roberto, De Fabritiis, Paolo, Caravita di Toritto, Tommaso, Gheorghita, Emanuil, Oriol, Albert, Rowlings, Philip, Emanuele, Angelucci, Carella, Angelo M, Offidani, Massimo, Bladé, Joan, Casado, Luis F, Oakervee, Heather, Panelli, Victoria, Meza, Luis, Kühr, Thomas, Granell, Miguel, Benson, Don, Nair, Rajesh, Holden, Viran, Reeves, James, Jr., Eek, Richard W, Walker, Patricia A, Catalano, John, Rosta, András, Lech-Marańda, Ewa, Samaras, Christy, Reiman, Anthony, Weaver, Robert, Acs, Peter, Grigg, Andrew, De Prijck, Bernard, Louzada, Martha, Minuk, Leonard, Sebag, Michael, Klausmann, Martine, Welslau, Manfred, Hellmann, Andrzej, Danaila, Catalin, Becker, Pamela, Bensinger, William, Porterfield, Bruce, Modiano, Manuel, Schultz, Stephen M, Manges, Robert, Lee, Huey-Shin Cindy, Gray, James X, Wright, Matthew P, Vekemans, Marie-Christine, Hamed, Aryan, Gasztonyi, Zoltán, Mikala, Gábor, Masszi, Tamás, Gamberi, Barbara, Kuliczkowski, Kazimierz, Usnarska-Zubkiewicz, Lidia, Bengoechea, Enrique, Gutiérrez, María AE, García, Miguel TH, San-Miguel, Jesús, Driessen, Christoph, Behl, Rajesh, Brenner, Warren, Gray, Carl, Hansen, Vincent, Moezi, Mehdi, Cortes, Hector V, Yen, Charles, Gressot, Laurent, Horvath, Noemi, D'Rozario, James M, Latimer, Maya, Kyrtsonis, Maria-Christine, Chubar, Evgeni, Mittelman, Moshe, Baldini, Luca, Tosi, Patrizia, Vacca, Angelo, Jędrzejczak, Wiesław W, Robak, Tadeusz, Lahuerta, Juan J, Carney, Jennifer, Chen, Franklin, Hirsch, Robert, Ruiz, Marco, Alencar, Alvaro, Jagasia, Madan, Kasbari, Samer, Kuriakose, Philip, Mahmood, Aftab, Chaudhry, Madhu, Cohen, Gary, Noga, Stephen, Roa, Sch, Jakubowiak, Andrzej, Rosenbaum, Cara, Delforge, Michel, Delrieu, Vanessa, Doyen, Chantal, Dries, Deeren, Demuynck, Hilde, Schots, Rik, Maisnar, Vladimir, Blau, Igor W, Dürk, Heinz A, Kerkhoff, Andrea, Kropff, Martin, Munder, Markus, Röllig, Christoph, Scheid, Christof, Symeonidis, Argiris S, Illés, Árpád, Coyne, Mark, O'Gorman, Peter, Hayden, Patrick, O'Dwyer, Michael, Ben-Yehuda, Dina, Braester, Andrei, Nemets, Anatoly, Lugassy, Gilles, Cohen, Yossi, Rahimi-Levene, Naomi, Bosi, Alberto, Pezzatti, Sara, Rossini, Fausto, Pogliani, Enrico M, Pinto, Antonello, Komarnicki, Mieczysław, Borsaru, Gabriela, Stoia, Razvan, Afanasyev, Boris, Goñi, María A, Carboneras, Ana V, Ali, Sarah, Rubenstein, S. Eric, Caputto, Salvador, Cosgriff, Thomas, Fanning, Suzanne, Khojasteh, Ali, Liman, Andrew, Malcolm, Albert, Vrindavanam, Nandagopal, Patel, Ravindranath, Belani, Rajesh, Shieh, Marie, Stockerl-Goldstein, Keith, Strnad, Charles, Stuart, Robert, Chhabra, Saurabh, Costa, Luciano, Jhangiani, Haresh, Augustson, Bradley, Filshie, Robin, Johnston, Amanda, Hertzberg, Mark S, Mineur, Philippe, Fox, Susan, Kotb, Rami, Dao, Vi, LeBlanc, Richard, Gregora, Evzen, Brioli, Annamaria, Mügge, Lars-Olof, Hänel, Mathias, Langer, Christian, Kapsali, Eleni, Briasoulis, Evangelos, Kyriakou, Despoina, Hardan, Izhar, Horowitz, Netanel A, Clotilde, Cangialosi, Fabbiano, Francesco, Castagnari, Barbara, Ciceri, Fabio, Musuraca, Gerardo, Deptała, Andrzej, Kłoczko, Janusz, Balea, Marius, Vladareanu, Ana-Maria, Rossiev, Victor, Alegre, Adrián, Encinas, Cristina, Gayoso, Jorge, Pabst, Thomas, Rabin, Neil, Arledge, Sherri, Cabanillas, Fernando, Catlett, Joseph, Chidiac, Tarek, Clarkson, David, Dhodapkar, Madhav, Geils, George, Jr., Khan, Cyrus MA, Sahovic, Entezam, Khasawneh, Mohamad, Sehgal, Rajesh, Ballester, Oscar, Levy, Moshe, Fay, Joseph, Liem, Kiem, Lunning, Matthew, Vose, Julie, Faber, Edward, Jr., MacFarlane, Donald, Hohl, Raymond, Mahmood, Tariq, Bhaskar, Birbal, Mims, Martha, Oliff, Ira, Paner, Agne, Maciejewski, John, Padmanabhan, Arvinda, Richard, Robert, Sanyal, Amit, Schiller, Gary, Staszewski, Harry, Stevens, Don, Vaughn, Christopher, and Windsor, Kevin

Published
2022
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12. Real-world data on Len/Dex combination at second-line therapy of multiple myeloma: treatment at biochemical relapse is a significant prognostic factor for progression-free survival

Author

Katodritou, Eirini, Kyrtsonis, Marie-Christine, Delimpasi, Sosana, Kyriakou, Despoina, Symeonidis, Argiris, Spanoudakis, Emmanouil, Vasilopoulos, Georgios, Anagnostopoulos, Achilles, Kioumi, Anna, Zikos, Panagiotis, Aktypi, Anthi, Briasoulis, Evangelos, Megalakaki, Aikaterini, Repousis, Panayiotis, Adamopoulos, Ioannis, Gogos, Dimitrios, Kotsopoulou, Maria, Pappa, Vassiliki, Papadaki, Eleni, Fotiou, Despoina, Nikolaou, Eftychia, Giannopoulou, Evlambia, Hatzimichael, Eleftheria, Giannakoulas, Nikolaos, Douka, Vassiliki, Kokoviadou, Kyriaki, Timotheatou, Despoina, and Terpos, Evangelos

Published
2018
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15. Systemic Therapy of Bone Metastases

Author

Kamposioras, Konstantinos, Briasoulis, Evangelos, Ablin, Richard J., Series editor, Jiang, Wen G., Series editor, Vassiliou, Vassilios, editor, Chow, Edward, editor, and Kardamakis, Dimitrios, editor

Published
2014
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16. A retrospective study of azacitidine treatment in patients with intermediate-2 or high risk myelodysplastic syndromes in a real-world clinical setting in Greece

Author

Pappa, Vasiliki, Anagnostopoulos, Achilles, Bouronikou, Eleni, Briasoulis, Evangelos, Kotsianidis, Ioannis, Pagoni, Maria, Zikos, Panagiotis, Tsionos, Konstantinos, Viniou, Nora, Meletis, John, Papadaki, Helen, Kioumi, Anna, Galanopoulos, Athanasios, Vervessou, Elisavet-Christine, Poulakidas, Elias, Karmas, Panagiotis, Karvounis, Kiki, and Symeonidis, Argiris

Published
2017
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17. Hormonotherapy of Bone Metastases

Author

Kamposioras, Konstantinos, Briasoulis, Evangelos, Ablin, Richard J., editor, Jiang, Wen G., editor, Kardamakis, Dimitrios, editor, Vassiliou, Vassilios, editor, and Chow, Edward, editor

Published
2009
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20. “Real-world” data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group

Author

Katodritou, Eirini, Vadikolia, Chrysanthi, Lalagianni, Chrysavgi, Kotsopoulou, Maria, Papageorgiou, Georgia, Kyrtsonis, Marie-Christine, Matsouka, Panagiota, Giannakoulas, Nikolaos, Kyriakou, Despoina, Karras, Georgios, Anagnostopoulos, Nikolaos, Michali, Evridiki, Briasoulis, Evangelos, Hatzimichael, Eleftheria, Spanoudakis, Emmanouil, Zikos, Panagiotis, Tsakiridou, Anastasia, Tsionos, Konstantinos, Anargyrou, Konstantinos, Symeonidis, Argiris, Maniatis, Alice, and Terpos, Evangelos

Published
2014
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21. Correction to: Real-world data on Len/Dex combination at second-line therapy of multiple myeloma: treatment at biochemical relapse is a significant prognostic factor for progression-free survival

Author

Katodritou, Eirini, Kyrtsonis, Marie-Christine, Delimpasi, Sosana, Kyriakou, Despoina, Symeonidis, Argiris, Spanoudakis, Emmanouil, Vasilopoulos, Georgios, Anagnostopoulos, Achilles, Kioumi, Anna, Zikos, Panagiotis, Aktypi, Anthi, Briasoulis, Evangelos, Megalakaki, Aikaterini, Repousis, Panayiotis, Adamopoulos, Ioannis, Gogos, Dimitrios, Kotsopoulou, Maria, Pappa, Vassiliki, Papadaki, Eleni, Fotiou, Despoina, Nikolaou, Eftychia, Giannopoulou, Evlambia, Hatzimichael, Eleftheria, Giannakoulas, Nikolaos, Douka, Vassiliki, Kokoviadou, Kyriaki, Timotheatou, Despoina, and Terpos, Evangelos

Published
2018
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24. Postoperative dose-dense sequential versus concomitant administration of epirubicin and paclitaxel in patients with node-positive breast cancer: 5-year results of the Hellenic Cooperative Oncology Group HE 10/00 phase III Trial

Author

Gogas, Helen, Dafni, Urania, Karina, Maria, Papadimitriou, Christos, Batistatou, Anna, Bobos, Mattheos, Kalofonos, Haralabos P., Eleftheraki, Anastasia G., Timotheadou, Eleni, Bafaloukos, Dimitrios, Christodoulou, Christos, Markopoulos, Christos, Briasoulis, Evangelos, Papakostas, Pavlos, Samantas, Epaminontas, Kosmidis, Paris, Stathopoulos, George P., Karanikiotis, Charisios, Pectasides, Dimitrios, Dimopoulos, Meletios A., and Fountzilas, George

Published
2012
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25. Population Pharmacokinetics and Pharmacodynamics of Doxorubicin and Cyclophosphamide in Breast Cancer Patients: A Study by the EORTC-PAMM-NDDG

Author

Joerger, Markus, Huitema, Alwin D. R., Richel, Dick J., Dittrich, Christian, Pavlidis, Nikolas, Briasoulis, Evangelos, Vermorken, Jan B., Strocchi, Elena, Martoni, Andrea, Sorio, Roberto, Sleeboom, Henk P., Izquierdo, Miguel A., Jodrell, Duncan I., Féty, Régine, de Bruijn, Ernst, Hempel, Georg, Karlsson, Mats, Tranchand, Brigitte, Schrijvers, Ad H. G. J., Twelves, Chris, Beijnen, Jos H., and Schellens, Jan H. M.

Published
2007
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27. ICAM-1 expression in patients with advanced non-small cell lung cancer treated with radiotherapy

Author

Pinelopi, Gkogkou, Evangelia, Peponi, Dimitrios, Ntaskagiannis, Asimo, Demou, Elli, Ioakeim, Briasoulis, Evangelos, and Periklis, Tsekeris

Subjects
Aged, 80 and over, Male, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Female, Middle Aged, Intercellular Adhesion Molecule-1, Immunohistochemistry, Aged
Abstract

To investigate the possible clinical relevance of ICAM-1 molecule in patients with advanced non-small cell lung cancer (NSCLC) treated with radiotherapy.The expression of ICAM-1 was examined immunohistochemically on tissue specimens of 62 patients with pathologically confirmed NCSLC. The median age at diagnosis was 62 years (range 49-84) with a male predominance (87.8%). All patients had stage III disease at presentation. The median follow up was 15.5 months (range 7-44). Obtained expression data were weighted against clinical and pathological parameters.Thirty-seven patients (60%) had no ICAM-1 staining, 16 patients (26%) had weak staining, while 6 patients (10%) expressed moderate staining and only 3 patients (5%) showed strong ICAM-1 staining. Moderate and high expressions were mostly observed in adenocarcinomas and undifferentiated carcinomas (n=8), that are considered more aggressive than squamous cell carcinoma (n=1). The median overall survival (OS) was 15 months (range 11-20). There seemed to exist an inverse association between ICAM-1 expression and OS, since there was a trend in median survival in favor of no ICAM-1 expression (p=0.083). Moreover, in patients with no ICAM-1 expression, there was observed a statistically significant difference in OS, favoring the squamous cell subtype (p=0.006). Nevertheless, ICAM-1 expression did not confer any statistical significance regarding smoking status (p=0.128), metastatic potential (p=0.574) as well as with the site of metastasis (p=0.964).Our findings may serve as a helping resource for further investigations of ICAM-1 as a molecular marker that could characterize treatment response and survival of tumor subpopulations.

Published
2020

32. Paclitaxel and carboplatin as first-line chemotherapy combined with gefitinib (IRESSA) in patients with advanced breast cancer: a phase I/II study conducted by the Hellenic Cooperative Oncology Group

Author

Fountzilas, George, Pectasides, Dimitrios, Kalogera-Fountzila, Anna, Skarlos, Dimosthenis, Kalofonos, Haralambos P., Papadimitriou, Christos, Bafaloukos, Dimitrios, Lambropoulos, Stefanos, Papadopoulos, Savvas, Kourea, Helen, Markopoulos, Christos, Linardou, Helen, Mavroudis, Dimitrios, Briasoulis, Evangelos, Pavlidis, Nicholaos, Razis, Evangelia, Kosmidis, Paraskevas, and Gogas, Helen

Published
2005
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35. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. Beatriz P.P., additional, Orihara, Yutaka, additional, Ortega, Almudena, additional, Ortega-García, Francisca, additional, Osada, Jesús, additional, Özdemir, Durmuş, additional, Öztürk, Betül, additional, Pacheco, Yolanda M., additional, Paice, Alistair G., additional, Palmerini, Carlo A., additional, Panagiotakos, Demosthenes, additional, Panagou, E.Z., additional, Panzella, Lucia, additional, Papoti, V.T., additional, Paradiso, Vito Michele, additional, Pariente, José Antonio, additional, Patel, Vinood B., additional, Peinado, M. Ángeles, additional, Pellicanò, Teresa Maria, additional, Peragon, Juan, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Perona, Javier Sanchez, additional, Piperno, Anna, additional, Planas, Joana M., additional, Pollicino, Donatella, additional, Polzonetti, Valeria, additional, Populin, Tiziana, additional, Portillo, Maria P., additional, Pozo, David, additional, Prenzler, Paul, additional, Prieto, Pablo G., additional, Pucciarelli, Stefania, additional, Puel, Caroline, additional, Puertollano, Elena, additional, Puertollano, María A., additional, Quesada-Granados, Jose Javier, additional, Rajendram, Rajkumar, additional, Ramírez-Expósito, María Jesús, additional, Ramos, Sonia, additional, Ramos-Martos, Natividad, additional, Randazzo, Cinzia L., additional, Rando, Rossana, additional, Reiter, Russel J., additional, Rejano, Luis, additional, Rhee, Hae-Ik, additional, Robards, Kevin, additional, Rodriguez, Hector, additional, Rodríguez-Cabezas, Maria Elena, additional, Rodríguez-Manero, Moises, additional, Rodríguez-Méndez, María L., additional, Rodríguez, Rosalía, additional, Rodriguez-Rodriguez, Rosalia, additional, Romani, Annalisa, additional, Romero, Concepción, additional, Romero, Maria-Paz, additional, Romero-Gonzalez, Roberto, additional, Rose, Martin, additional, Rossi, Mauro, additional, Rotondi, Annalisa, additional, Rowland, Ian R., additional, Ruiz, Adolfina, additional, Ruiz-Gutiérrez, Valentina, additional, Russo, Francesco, additional, Ryan, Danielle, additional, Sabatini, Nadia, additional, Sacco, Antonio, additional, Sahan, Yasemin, additional, Saitta, Marcello, additional, Salvador, Maria Desamparados, additional, Samperi, Roberto, additional, Samaniego-Sánchez, Cristina, additional, Sánchez, Antonio Higinio, additional, Sánchez-Navarro, Maria Rosa, additional, Sancho, Verónica, additional, Santos-González, Mónica, additional, Saraiva, Jorge A., additional, Scampicchio, Matteo, additional, Scazzocchio, Beatrice, additional, Schmitt, Christoph A., additional, Schwartz, Betty, additional, Sciuto, Sebastiano, additional, Scoditti, Egeria, additional, Seabra, Rosa M., additional, Sebastiani, Luca, additional, Segre, Anna Laura, additional, Segura, Antonio, additional, Servili, Maurizio, additional, Shiraishi, Ryosuke, additional, Siculella, Luisa, additional, Simão, Andréa Colado, additional, Sindona, Giovanni, additional, Sivakumar, Ganapathy, additional, Skaltsounis, Alexios-Leandros, additional, Smith, Amos B., additional, Spatafora, Carmela, additional, Sperry, Jeffrey B., additional, Soares, Mario J., additional, Soriguer, Federico, additional, Srirajaskanthan, Rajaventhan, additional, Stitia, Naïm, additional, Tabernero, Arantxa, additional, Tagarelli, Antonio, additional, Tai, Fuju, additional, Tamborrino, Antonia, additional, Tassou, C.C., additional, Tesseromatis, Christine, additional, Todeschini, Roberto, additional, Torrecilla, Jose S., additional, Trikib, Saïda, additional, Tringali, Corrado, additional, Tsakiris, Ioannis N., additional, Tsatsakis, Aristidis M., additional, Tsimidou, M.Z., additional, Uccella, Nicola A., additional, Urbano, Francisco J., additional, Valcarcel, Miguel, additional, Valencia-Serrano, Félix, additional, Valentão, Patrícia, additional, Valverde, Isabel, additional, Varela, Lourdes M., additional, Varì, Rosaria, additional, Simas Vaz, Fernando Antonio, additional, Vettorazzi, Ariane, additional, Vichi, Stefania, additional, Vidal, José Luis Martínez, additional, Villalba, José M., additional, Villalba, Mayte, additional, Villanueva-Peñacarrillo, María L., additional, Vincenzetti, Silvia, additional, Vita, Alberto, additional, Vlahov, Giovanna, additional, Wang, Wei, additional, Weisberg, Edmund, additional, Wenzel, Uwe, additional, Won, Se-Ra, additional, Wu, Bin, additional, Yago, María Dolores, additional, Zabaras, Dimitrios, additional, Zappia, Vincenzo, additional, Zarzuelo, Antonio, additional, and Zhang, Luyong, additional

Published
2010
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47. The neutrophil, not the tumor. Serum CA 15-3 as a result of granulocyte--colony-stimulating factor-induced neutrophil MUC1 overexpression and neutrophilia in patients with breast carcinoma receiving adjuvant chemotherapy

Author

Pentheroudakis, George, Malamou-Mitsi, Vassiliki, Briasoulis, Evangelos, Damala, Konstantina, Vassou, Amalia, Vartholomatos, George, Kolaitis, Nikos, and Pavlidis, Nikolas

Subjects
Breast cancer -- Drug therapy, Cancer -- Adjuvant treatment, Cancer -- Complications and side effects, Health
Published
2004

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