8 results on '"Breukink, M. B."'
Search Results
2. Severe phenotypes of chronic central serous chorioretinopathy: clinical characteristics and response to photodynamic therapy
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Mohabati, D., van Dijk, E. H. C., van Rijssen, T. J., de Jong, E. K., Breukink, M. B., Martinez-Ciriano, J. P., Dijkman, G., Hoyng, C. B., Fauser, S., Yzer, S., Boon, C. J. F., Mohabati, D., van Dijk, E. H. C., van Rijssen, T. J., de Jong, E. K., Breukink, M. B., Martinez-Ciriano, J. P., Dijkman, G., Hoyng, C. B., Fauser, S., Yzer, S., and Boon, C. J. F.
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- 2017
3. ASSOCIATION BETWEEN DONOR MBL PROMOTER HAPLOTYPE AND GRAFT SURVIVAL AND THE DEVELOPMENT OF BOS AFTER LUNG TRANSPLANTATION
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Munster, J M., primary, van der Bij, W, additional, Breukink, M B., additional, van der Steege, G, additional, Zuurman, M W., additional, Hepkema, B G., additional, Verschuuren, E A.M., additional, van Son, W J., additional, and Seelen, M A.J., additional
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- 2008
- Full Text
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4. Focal and Diffuse Chronic Central Serous Chorioretinopathy Treated With Half-Dose Photodynamic Therapy or Subthreshold Micropulse Laser: PLACE Trial Report No. 3
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Robert E MacLaren, Thomas J. van Rijssen, Susan M. Downes, Rocio Blanco-Garavito, Camiel J. F. Boon, Sascha Fauser, Elon H. C. van Dijk, Eric H Souied, Giuseppe Querques, Myrte B. Breukink, Paula Scholz, Jan E.E. Keunen, Carel B. Hoyng, van Rijssen, T. J., van Dijk, E. H. C., Scholz, P., Breukink, M. B., Blanco-Garavito, R., Souied, E. H., Keunen, J. E. E., Maclaren, R. E., Querques, G., Fauser, S., Downes, S. M., Hoyng, C. B., Boon, C. J. F., ANS - Complex Trait Genetics, and Ophthalmology
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Male ,Time Factors ,Visual acuity ,Fundus Oculi ,medicine.medical_treatment ,Visual Acuity ,Photodynamic therapy ,Chronic central serous chorioretinopathy ,Retina ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,law.invention ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Humans ,Medicine ,Fluorescein Angiography ,Retrospective Studies ,Photosensitizing Agents ,medicine.diagnostic_test ,Choroid ,business.industry ,Lasers ,Verteporfin ,Retrospective cohort study ,Middle Aged ,Fluorescein angiography ,Ophthalmology ,Treatment Outcome ,Central Serous Chorioretinopathy ,Photochemotherapy ,chemistry ,Chronic Disease ,Female ,Subretinal fluid ,medicine.symptom ,business ,Nuclear medicine ,Indocyanine green ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
Item does not contain fulltext PURPOSE: To compare the outcome between high-density subthreshold micropulse laser (HSML) treatment and half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (cCSC) patients, subdivided based on either focal or diffuse leakage on fluorescein angiography (FA). DESIGN: Retrospective analysis of multicenter randomized controlled trial data. METHODS: Patients were treated with either half-dose PDT or HSML (both indocyanine green angiography-guided) and categorized in 2 groups, based on focal or diffuse leakage on FA. Clinical outcomes were evaluated at baseline and during follow-up. RESULTS: In the focal leakage group (63 patients), both at first evaluation and at final visit, more PDT-treated than HSML-treated patients demonstrated a resolution of subretinal fluid (evaluation visit 1: 57% in the PDT group and 17% in the HSML group, P = .007; final visit: 75% and 38%, P = .012). In the diffuse leakage group (93 patients), both at first evaluation and at final visit, more PDT-treated than HSML-treated patients showed a resolution of subretinal fluid (evaluation visit: 1:48% in the PDT group and 16% in the HSML group, P = .002; final visit: 67% and 21%, P = .002). PDT-treated patients in the focal and diffuse leakage group had a higher retinal sensitivity increase, comparing baseline and final visit (+3.1 +/- 3.1 dB vs +1.2 +/- 4.0 dB, P = .048, and +2.7 +/- 3.3 dB vs +1.0 +/- 3.8 dB, P = .036, respectively). Only in the diffuse leakage group, the increase in ETDRS letters was higher in the PDT-treated group when comparing baseline and first evaluation visit (+4.4 +/- 6.1 vs +0.9 +/- 10.0, P = .049). CONCLUSIONS: Half-dose PDT is superior to HSML treatment in cCSC patients, regardless of the presence of focal or diffuse leakage on FA.
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- 2019
5. Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage
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Elon H. C. van Dijk, Giuseppe Querques, Susan M. Downes, Paula Scholz, Carel B. Hoyng, Eric H Souied, Thomas J. van Rijssen, Myrte B. Breukink, Robert E MacLaren, Rocio Blanco-Garavito, Camiel J. F. Boon, Sascha Fauser, Ophthalmology, ANS - Complex Trait Genetics, van Rijssen, T. J., van Dijk, E. H. C., Scholz, P., Breukink, M. B., Blanco-Garavito, R., Souied, E. H., Maclaren, R. E., Querques, G., Fauser, S., Hoyng, C. B., Downes, S. M., and Boon, C. J. F.
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Male ,Fluorescein angiography ,Visual acuity ,Central serous chorioretinopathy ,Visual Acuity ,Patient characteristics ,Chronic central serous chorioretinopathy ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,0302 clinical medicine ,Retrospective Studie ,Fluorescein Angiography ,Focal leakage ,Leakage (electronics) ,medicine.diagnostic_test ,05 social sciences ,Subretinal Fluid ,Diabetic retinopathy ,Middle Aged ,Sensory Systems ,Central Serous Chorioretinopathy ,Female ,medicine.symptom ,Tomography, Optical Coherence ,Human ,medicine.medical_specialty ,Fundus Oculi ,Retina ,Follow-Up Studie ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,All institutes and research themes of the Radboud University Medical Center ,Ophthalmology ,0502 economics and business ,medicine ,Humans ,Indocyanine green angiography ,Retrospective Studies ,business.industry ,Choroid ,Mean age ,medicine.disease ,Diffuse leakage ,Chronic Disease ,030221 ophthalmology & optometry ,050211 marketing ,Subretinal fluid ,business ,Follow-Up Studies - Abstract
Purpose: To describe the characteristics and potential differences between focal and diffuse phenotypes of untreated chronic central serous chorioretinopathy (cCSC). Methods: For this study, patients were divided in two groups. Focal leakage was defined as 1 “hot spot” of leakage, whereas diffuse leakage was defined as either > 1 hot spot or a larger area of widespread leakage on FA. Clinical characteristics were assessed at presentation. After Bonferroni correction, P values < 0.00125 were deemed statistically significant. Results: The focal leakage group included 68 eyes (53 males), and the diffuse leakage group included 105 eyes (88 males). Mean best-corrected visual acuity (BCVA) was 77.1 ± 8.1 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the focal group and 76.0 ± 9.6 ETDRS letters in the diffuse group (p = 0.440). In the focal group, mean age was 46.9 ± 8.8years, whereas this was 49.7 ± 8.3years in the diffuse group (p = 0.033). Mean central foveal thickness was 107.1 ± 21.3μm in the focal group and 106.2 ± 27.3μm in the diffuse group (p = 0.818). Mean choroidal thickness was 407.5 ± 114.8μm in the focal group and 419.1 ± 113.9μm in the diffuse group (p = 0.578). In the focal group, subretinal fluid was present in the fellow eye in 16% of the patients, as compared to 29% in the diffuse group (p = 0.067). Conclusions: In untreated cCSC patients with focal or diffuse leakage on FA, no marked differences in clinical characteristics were found. Extensive choroidal abnormalities may be present in both groups, which are presumed to lie at the basis of the development of cCSC.
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- 2019
6. Reply
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Elon H.C. van Dijk, Sascha Fauser, Myrte B. Breukink, Rocio Blanco-Garavito, Joannes M.M. Groenewoud, Jan E.E. Keunen, Petrus J.H. Peters, Greet Dijkman, Eric H. Souied, Robert E. MacLaren, Giuseppe Querques, Susan M. Downes, Carel B. Hoyng, Camiel J.F. Boon, van Dijk, E. H. C., Fauser, S., Breukink, M. B., Blanco-Garavito, R., Groenewoud, J. M. M., Keunen, J. E. E., Peters, P. J. H., Dijkman, G., Souied, E. H., Maclaren, R. E., Querques, G., Downes, S. M., Hoyng, C. B., Boon, C. J. F., Ophthalmology, and Amsterdam Neuroscience - Complex Trait Genetics
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Ophthalmology ,Central Serous Chorioretinopathy ,Photochemotherapy ,Chronic Disease ,Humans - Published
- 2018
7. Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial
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Myrte B. Breukink, Eric H Souied, Giuseppe Querques, Susan M. Downes, Robert E MacLaren, Greet Dijkman, Camiel J. F. Boon, Sascha Fauser, Joannes M. M. Groenewoud, Petrus J.H. Peters, Carel B. Hoyng, Rocio Blanco-Garavito, Jan E.E. Keunen, Elon H. C. van Dijk, van Dijk, E. H. C., Fauser, S., Breukink, M. B., Blanco-Garavito, R., Groenewoud, J. M. M., Keunen, J. E. E., Peters, P. J. H., Dijkman, G., Souied, E. H., Maclaren, R. E., Querques, G., Downes, S. M., Hoyng, C. B., Boon, C. J. F., Ophthalmology, and ANS - Cellular & Molecular Mechanisms
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Male ,medicine.medical_specialty ,Visual acuity ,Fundus Oculi ,Visual Acuity ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,Retinal Pigment Epithelium ,Multimodal Imaging ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Ophthalmology ,medicine ,Clinical endpoint ,Humans ,Fluorescein Angiography ,Photosensitizing Agents ,medicine.diagnostic_test ,Dose-Response Relationship, Drug ,business.industry ,Choroid ,Verteporfin ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Fluorescein angiography ,eye diseases ,Clinical trial ,Ophthalmoscopy ,Treatment Outcome ,Central Serous Chorioretinopathy ,Photochemotherapy ,030221 ophthalmology & optometry ,Secondary Outcome Measure ,Female ,Laser Therapy ,medicine.symptom ,business ,Microperimetry ,030217 neurology & neurosurgery ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
Contains fulltext : 196622.pdf (Publisher’s version ) (Open Access) PURPOSE: To compare the anatomic and functional efficacy and safety of half-dose photodynamic therapy (PDT) versus high-density subthreshold micropulse laser (HSML) treatment in patients with chronic central serous chorioretinopathy (cCSC). DESIGN: Open-label, multicenter, randomized controlled clinical trial. PARTICIPANTS: Patients with cCSC whose disease had to be confirmed by both clinical characteristics and findings on multimodal imaging. METHODS: Eligible patients were randomized in a 1:1 allocation ratio. Treatment was evaluated during a follow-up visit, and the same treatment was repeated in patients who still demonstrated subretinal fluid (SRF). MAIN OUTCOME MEASURES: The primary end point was the complete disappearance of SRF at the first evaluation visit at 6 to 8 weeks after treatment. As a secondary outcome measure, we assessed this anatomic result at the final evaluation visit at 7 to 8 months after treatment. Other secondary outcomes covered functional improvement and included change in best-corrected visual acuity (BCVA; measured in Early Treatment Diabetic Retinopathy Study [ETDRS] letters), retinal sensitivity (measured using microperimetry), and vision-related quality of life using a validated questionnaire. RESULTS: Between November 2013 and September 2016, 179 patients were included: 89 patients were assigned randomly to half-dose PDT, and 90 were assigned randomly to HSML treatment. At their first evaluation visit, SRF had resolved in 51.2% and 13.8% of patients, respectively (P < 0.001). At their final evaluation visit, a significantly higher percentage of PDT-treated patients demonstrated no SRF (67.2% vs. 28.8%; P < 0.001). Moreover, at the first evaluation visit, the PDT-treated patients showed a significantly higher increase in BCVA (+4.60+/-6.62 ETDRS letters vs. +1.39+/-8.99 ETDRS letters; P = 0.011), and a significantly higher increase in retinal sensitivity on microperimetry (+2.01+/-3.04 dB vs. +0.92+/-3.65 dB; P = 0.046); however, the improvement in vision-related quality of life was similar (score of +2.87+/-8.35 vs. +2.56+/-7.36, respectively; P = 0.800). CONCLUSIONS: Half-dose PDT is superior to HSML for treating cCSC, leading to a significantly higher proportion of patients with complete resolution of SRF and functional improvement.
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- 2018
8. Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
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Susan M. Downes, Carel B. Hoyng, Alexander J. M. Dingemans, Anneke I. den Hollander, Camiel J. F. Boon, Sascha Fauser, Robert E MacLaren, Myrte B. Breukink, Jan E.E. Keunen, Giuseppe Querques, ANS - Complex Trait Genetics, Breukink, M. B., Dingemans, A. J. M., Den Hollander, A. I., Keunen, J. E. E., Macllaren, R. E., Fauser, S., Querques, G., Hoyng, C. B., Downes, S. M., and Boon, C. J. F.
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0301 basic medicine ,micropulse laser ,medicine.medical_specialty ,Visual acuity ,genetic structures ,chronic central serous chorioretinopathy ,Long term follow up ,Vision-related quality of life ,Sensory disorders Radboud Institute for Health Sciences [Radboudumc 12] ,Chronic central serous chorioretinopathy ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,03 medical and health sciences ,0302 clinical medicine ,Optical coherence tomography ,Quality of life ,PDT ,Ophthalmology ,medicine ,vision-related quality of life ,Patient group ,Original Research ,medicine.diagnostic_test ,business.industry ,Micropulse laser ,Clinical Ophthalmology ,NEI-VFQ-39 ,medicine.disease ,Fluorescein angiography ,eye diseases ,030104 developmental biology ,030221 ophthalmology & optometry ,sense organs ,medicine.symptom ,business ,Progressive disease - Abstract
Myrte B Breukink,1,* Alexander JM Dingemans,1,* Anneke I den Hollander,1,2 Jan EE Keunen,1 Robert E MacLaren,3,4 Sascha Fauser,5 Giuseppe Querques,6 Carel B Hoyng,1 Susan M Downes,3,4 Camiel JF Boon1,7 1Department of Ophthalmology, 2Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; 3Oxford Eye Hospital, Oxford University Hospitals NHS Trust, 4Nuffield Laboratory of Ophthalmology and NIHR Biomedical Research Centre, Department of Clinical Neurosciences, University of Oxford, Oxford, UK; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France; 7Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands *These authors contributed equally to this work Purpose: To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC).Materials and methods: This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual Function Questionnaire [NEI-VFQ]-39) were analyzed.Results: Mean visual acuity showed a significant decline over time of 0.16 logarithm of minimum angle of resolution ([logMAR] range: -0.22 to 1.3;P=0.009) after a mean follow-up period of 10.6 years. Also, patients reported lower vision-related quality of life based on the NEI-VFQ-39 for almost all categories compared to healthy controls. Macular atrophy was diagnosed more often on optical coherence tomography compared to other diagnostic entities. Retinal pigmentepithelium detachments in the macula were documented on optical coherence tomography in 56% of the patients. A significant thinning of foveal thickness was measured over time compared to unaffected fellow eyes (P=0.002). On long-term follow-up, 13 eyes (37%) showed an increase in number of hot spots on fluorescein angiography.Conclusion: This study indicates that cCSC is a progressive disease in many patients, causing a progressive decline in visual acuity, accompanied by lower reported vision-related quality of life. In deciding whether or not to treat, the progressive nature of cCSC should be taken into account in this relatively young and often still professionally active patient group. Keywords: chronic central serous chorioretinopathy, micropulse laser, NEI-VFQ-39, PDT, vision-related quality of life
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- 2017
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