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2 results on '"Brett D. Atwater, MD"'

1. Sex differences in left ventricular electrical dyssynchrony and outcomes with cardiac resynchronization therapy

Author

Daniel J. Friedman, MD, Kasper Emerek, MD, Peter L. Sørensen, MSc, Emily P. Zeitler, MD, MHS, Sarah A. Goldstein, MD, Sana M. Al-Khatib, MD, MHS, FHRS, Peter Søgaard, MD, Claus Graff, PhD, and Brett D. Atwater, MD

Subjects
Cardiac resynchronization therapy, Left bundle branch block, QRS duration, Sex, Vectorcardiography, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Women seem to derive more benefit from cardiac resynchronization therapy (CRT) than men, even after accounting for the higher burden of risk factors for nonresponse often observed in men. Objective: To assess for sex-specific differences in left ventricular (LV) electrical dyssynchrony as a contributing electrophysiological explanation for the greater degree of CRT benefit among women. Methods: We compared the extent of baseline LV electrical dyssynchrony, as measured by the QRS area (QRSA), among men and women with left bundle branch block (LBBB) undergoing CRT at Duke University (n = 492, 35% women) overall and in relation to baseline QRS characteristics using independent sample t tests and Pearson correlation coefficients. Cox regression analyses were used to relate sex, QRSA, and QRS characteristics to the risk of cardiac transplantation, LV assist device implant, or death. Results: Although the mean QRS duration (QRSd) did not differ by sex, QRSA was greater for women vs men (113.8 μVs vs 98.2 μVs, P < .001), owing to differences in the QRSd

Published
2020
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2. Catheter ablation of atrial fibrillation in patients with diabetes mellitus

Author

Allen Wang, MD, Tracy Truong, MB, Eric Black-Maier, MD, Cynthia Green, PhD, Kristen B. Campbell, PharmD, Adam S. Barnett, MD, Janice Febre, BSN, RN, Zak Loring, MD, MHS, Sana M. Al-Khatib, MD, MHS, FHRS, Brett D. Atwater, MD, James P. Daubert, MD, FHRS, Camille Frazier-Mills, MD, MHS, Donald D. Hegland, MD, Kevin P. Jackson, MD, Larry R. Jackson, MD, Jason I. Koontz, MD, PhD, Robert K. Lewis, MD, PhD, Sean D. Pokorney, MD, MBA, Albert Y. Sun, MD, Kevin L. Thomas, MD, Tristam D. Bahnson, MD, FHRS, and Jonathan P. Piccini, MD, MHS, FHRS

Subjects
Atrial fibrillation, Catheter ablation, Diabetes mellitus, Glycemic control, Outcomes, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. Objective: The purpose of this study was to compare AF ablation outcomes in patients with and those without DM. Methods: We performed a retrospective analysis of 351 consecutive patients who underwent first-time AF ablation. Clinical outcomes included freedom from recurrent atrial arrhythmia, symptom burden (Mayo AF Symptom Inventory score), cardiovascular and all-cause hospitalizations, and periprocedural complications. Results: Patients with DM (n = 65) were older, had a higher body mass index, more persistent AF, more hypertension, and larger left atrial diameter (P

Published
2020
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