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1. Association of part-time clinical work with well-being and mental health in General Internal Medicine: A survey among Swiss hospitalists

Author

Bretagne, Lisa, primary, Mosimann, Stefanie, additional, Roten, Christine, additional, Perrig, Martin, additional, Genné, Daniel, additional, Essig, Manfred, additional, Mancinetti, Marco, additional, Méan, Marie, additional, Darbellay Farhoumand, Pauline, additional, Huber, Lars C., additional, Weber, Elisabeth, additional, Knoblauch, Christoph, additional, Schoenenberger, Andreas W., additional, Frick, Sonia, additional, Wenemoser, Eliane, additional, Ernst, Daniel, additional, Bodmer, Michael, additional, Aujesky, Drahomir, additional, and Baumgartner, Christine, additional

Published
2023
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3. Interventions for preventing falls and fall‐related fractures in community‐dwelling older adults: A systematic review and network meta‐analysis

Author

Dautzenberg, Lauren, primary, Beglinger, Shanthi, additional, Tsokani, Sofia, additional, Zevgiti, Stella, additional, Raijmann, Renee C. M. A., additional, Rodondi, Nicolas, additional, Scholten, Rob J. P. M., additional, Rutjes, Anne W. S., additional, Di Nisio, Marcello, additional, Emmelot‐Vonk, Marielle, additional, Tricco, Andrea C., additional, Straus, Sharon E., additional, Thomas, Sonia, additional, Bretagne, Lisa, additional, Knol, Wilma, additional, Mavridis, Dimitris, additional, and Koek, Huiberdina L., additional

Published
2021
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4. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

Author

Blum, Manuel R, primary, Sallevelt, Bastiaan T G M, additional, Spinewine, Anne, additional, O’Mahony, Denis, additional, Moutzouri, Elisavet, additional, Feller, Martin, additional, Baumgartner, Christine, additional, Roumet, Marie, additional, Jungo, Katharina Tabea, additional, Schwab, Nathalie, additional, Bretagne, Lisa, additional, Beglinger, Shanthi, additional, Aubert, Carole E, additional, Wilting, Ingeborg, additional, Thevelin, Stefanie, additional, Murphy, Kevin, additional, Huibers, Corlina J A, additional, Drenth-van Maanen, A Clara, additional, Boland, Benoit, additional, Crowley, Erin, additional, Eichenberger, Anne, additional, Meulendijk, Michiel, additional, Jennings, Emma, additional, Adam, Luise, additional, Roos, Marvin J, additional, Gleeson, Laura, additional, Shen, Zhengru, additional, Marien, Sophie, additional, Meinders, Arend-Jan, additional, Baretella, Oliver, additional, Netzer, Seraina, additional, de Montmollin, Maria, additional, Fournier, Anne, additional, Mouzon, Ariane, additional, O’Mahony, Cian, additional, Aujesky, Drahomir, additional, Mavridis, Dimitris, additional, Byrne, Stephen, additional, Jansen, Paul A F, additional, Schwenkglenks, Matthias, additional, Spruit, Marco, additional, Dalleur, Olivia, additional, Knol, Wilma, additional, Trelle, Sven, additional, and Rodondi, Nicolas, additional

Published
2021
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5. Interventions for preventing falls and fall-related fractures in community-dwelling older adults: A systematic review and network meta-analysis

Author

Dautzenberg, Lauren, Beglinger, Shanthi, Tsokani, Sofia, Zevgiti, Stella, Raijmann, Renee C. M. A., Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W. S., Nisio, Marcello Di, Emmelot-Vonk, Marielle, Tricco, Andrea C., Straus, Sharon E., Thomas, Sonia, Bretagne, Lisa, Knol, Wilma, Mavridis, Dimitris, Koek, Huiberdina L., Dautzenberg, Lauren, Beglinger, Shanthi, Tsokani, Sofia, Zevgiti, Stella, Raijmann, Renee C. M. A., Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W. S., Nisio, Marcello Di, Emmelot-Vonk, Marielle, Tricco, Andrea C., Straus, Sharon E., Thomas, Sonia, Bretagne, Lisa, Knol, Wilma, Mavridis, Dimitris, and Koek, Huiberdina L.

Published
2021

6. Medication review interventions to reduce hospital readmissions in older people

Author

Dautzenberg, Lauren, Bretagne, Lisa, Koek, Huiberdina L., Tsokani, Sofia, Zevgiti, Stella, Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W., Nisio, Marcello Di, Raijmann, Renee C. M. A., Emmelot-Vonk, Marielle, Jennings, Emma L. M., Dalleur, Olivia, Mavridis, Dimitris, Knol, Wilma, Dautzenberg, Lauren, Bretagne, Lisa, Koek, Huiberdina L., Tsokani, Sofia, Zevgiti, Stella, Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W., Nisio, Marcello Di, Raijmann, Renee C. M. A., Emmelot-Vonk, Marielle, Jennings, Emma L. M., Dalleur, Olivia, Mavridis, Dimitris, and Knol, Wilma

Published
2021

7. Medication review interventions to reduce hospital readmissions in older people

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (SLuc) Département de pharmacie, Dautzenberg, Lauren, Bretagne, Lisa, Koek, Huiberdina L., Tsokani, Sofia, Zevgiti, Stella, Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W., Di Nisio, Marcello, Raijmann, Renee C. M. A., Emmelot‐Vonk, Marielle, Jennings, Emma L. M., Dalleur, Olivia, Mavridis, Dimitris, Knol, Wilma, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (SLuc) Département de pharmacie, Dautzenberg, Lauren, Bretagne, Lisa, Koek, Huiberdina L., Tsokani, Sofia, Zevgiti, Stella, Rodondi, Nicolas, Scholten, Rob J. P. M., Rutjes, Anne W., Di Nisio, Marcello, Raijmann, Renee C. M. A., Emmelot‐Vonk, Marielle, Jennings, Emma L. M., Dalleur, Olivia, Mavridis, Dimitris, and Knol, Wilma

Abstract

Objective: To assess the efficacy of medication review as an isolated intervention and with several co-interventions for preventing hospital readmissions in older adults. Methods: Ovid MEDLINE, Embase, The Cochrane Central Register of Controlled Trials and CINAHL were searched for randomized controlled trials evaluating the effectiveness of medication review interventions with or without co-interventions to prevent hospital readmissions in hospitalized or recently discharged adults aged ≥65, until September 13, 2019. Included outcomes were "at least one all-cause hospital readmission within 30 days and at any timeafter discharge from the index admission".

Published
2021

8. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (MGD) Département de pharmacie, UCL - (SLuc) Département de pharmacie, UCL - SSS/IRSS - Institut de recherche santé et société, Blum, Manuel R, Sallevelt, Bastiaan T G M, Spinewine, Anne, O’Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E, Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J A, Drenth-van Maanen, A Clara, Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J, Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend-Jan, Baretella, Oliver, Netzer, Seraina, de Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O’Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A F, Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas

Abstract

Objective: To examine the effect of optimising drug treatment on drug related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design: Cluster randomised controlled trial. Setting: 110 clusters of inpatient wards within university based hospitals in four European countries (Switzerland, Netherlands, Belgium, and Republic of Ireland) defined by attending hospital doctors. Participants: 2008 older adults (≥70 years) with multimorbidity (≥3 chronic conditions) and polypharmacy (≥5 drugs used long term). Intervention: Clinical staff clusters were randomised to usual care or a structured pharmacotherapy optimisation intervention performed at the individual level jointly by a doctor and a pharmacist, with the support of a clinical decision software system deploying the screening tool of older person’s prescriptions and screening tool to alert to the right treatment (STOPP/START) criteria to identify potentially inappropriate prescribing. Main outcome measure: Primary outcome was first drug related hospital admission within 12 months. Results: 2008 older adults (median nine drugs) were randomised and enrolled in 54 intervention clusters (963 participants) and 56 control clusters (1045 participants) receiving usual care. In the intervention arm, 86.1% of participants (n=789) had inappropriate prescribing, with a mean of 2.75 (SD 2.24) STOPP/START recommendations for each participant. 62.2% (n=491) had ≥1 recommendation successfully implemented at two months, predominantly discontinuation of potentially inappropriate drugs. In the intervention group, 211 participants (21.9%) experienced a first drug related hospital admission compared with 234 (22.4%) in the control group. In the intention-to-treat analysis censored for death as competing event (n=375, 18.7%), the hazard ratio for first drug related hospital admission was 0.95 (95% confidence interval 0.77 to 1.17). In the per protocol analysis, the hazard ratio for a drug relate

Published
2021

9. Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): Cluster randomised controlled trial

Author

Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, Rodondi, Nicolas, Apotheek Opleiding, Apotheek, Apotheek Klinische Farmacie, MS Geriatrie, Circulatory Health, Blum, Manuel R., Sallevelt, Bastiaan T.G.M., Spinewine, Anne, O'Mahony, Denis, Moutzouri, Elisavet, Feller, Martin, Baumgartner, Christine, Roumet, Marie, Jungo, Katharina Tabea, Schwab, Nathalie, Bretagne, Lisa, Beglinger, Shanthi, Aubert, Carole E., Wilting, Ingeborg, Thevelin, Stefanie, Murphy, Kevin, Huibers, Corlina J.A., Clara Drenth-Van Maanen, A., Boland, Benoit, Crowley, Erin, Eichenberger, Anne, Meulendijk, Michiel, Jennings, Emma, Adam, Luise, Roos, Marvin J., Gleeson, Laura, Shen, Zhengru, Marien, Sophie, Meinders, Arend Jan, Baretella, Oliver, Netzer, Seraina, De Montmollin, Maria, Fournier, Anne, Mouzon, Ariane, O'Mahony, Cian, Aujesky, Drahomir, Mavridis, Dimitris, Byrne, Stephen, Jansen, Paul A.F., Schwenkglenks, Matthias, Spruit, Marco, Dalleur, Olivia, Knol, Wilma, Trelle, Sven, and Rodondi, Nicolas

Published
2021

10. Medication review interventions to reduce hospital readmissions in older people

Author

Dautzenberg, Lauren, primary, Bretagne, Lisa, additional, Koek, Huiberdina L., additional, Tsokani, Sofia, additional, Zevgiti, Stella, additional, Rodondi, Nicolas, additional, Scholten, Rob J. P. M., additional, Rutjes, Anne W., additional, Di Nisio, Marcello, additional, Raijmann, Renee C. M. A., additional, Emmelot‐Vonk, Marielle, additional, Jennings, Emma L. M., additional, Dalleur, Olivia, additional, Mavridis, Dimitris, additional, and Knol, Wilma, additional

Published
2021
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12. Interventions for preventing falls and fall-related fractures in community-dwelling older adults: A systematic review and network meta-analysis

Author

Dautzenberg, Lauren, Beglinger, Shanthi, Tsokani, Sofia, Zevgiti, Stella, Raijmann, Renee C M A, Rodondi, Nicolas, Scholten, Rob J P M, Rutjes, Anne W.S., Di Nisio, Marcello, Emmelot-Vonk, Marielle, Tricco, Andrea C, Straus, Sharon E, Thomas, Sonia, Bretagne, Lisa, Knol, Wilma, Mavridis, Dimitris, and Koek, Huiberdina L

Subjects
610 Medicine & health, 360 Social problems & social services, 3. Good health
Abstract

OBJECTIVE To compare the effectiveness of single, multiple, and multifactorial interventions to prevent falls and fall-related fractures in community-dwelling older persons. METHODS MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for randomized controlled trials (RCTs) evaluating the effectiveness of fall prevention interventions in community-dwelling adults aged ≥65 years, from inception until February 27, 2019. Two large RCTs (published in 2020 after the search closed) were included in post hoc analyses. Pairwise meta-analysis and network meta-analysis (NMA) were conducted. RESULTS NMA including 192 studies revealed that the following single interventions, compared with usual care, were associated with reductions in number of fallers: exercise (risk ratio [RR] 0.83; 95% confidence interval [CI] 0.77-0.89) and quality improvement strategies (e.g., patient education) (RR 0.90; 95% CI 0.83-0.98). Exercise as a single intervention was associated with a reduction in falls rate (RR 0.79; 95% CI 0.73-0.86). Common components of multiple interventions significantly associated with a reduction in number of fallers and falls rate were exercise, assistive technology, environmental assessment and modifications, quality improvement strategies, and basic falls risk assessment (e.g., medication review). Multifactorial interventions were associated with a reduction in falls rate (RR 0.87; 95% CI 0.80-0.95), but not with a reduction in number of fallers (RR 0.95; 95% CI 0.89-1.01). The following single interventions, compared with usual care, were associated with reductions in number of fall-related fractures: basic falls risk assessment (RR 0.60; 95% CI 0.39-0.94) and exercise (RR 0.62; 95% CI 0.42-0.90). CONCLUSIONS In keeping with Tricco et al. (2017), several single and multiple fall prevention interventions are associated with fewer falls. In addition to Tricco, we observe a benefit at the NMA-level of some single interventions on preventing fall-related fractures.

13. Medication review interventions to reduce hospital readmissions in older people

Author

Dautzenberg, Lauren, Bretagne, Lisa, Koek, Huiberdina L, Tsokani, Sofia, Zevgiti, Stella, Rodondi, Nicolas, Scholten, Rob J P M, Rutjes, Anne W, Di Nisio, Marcello, Raijmann, Renee C M A, Emmelot-Vonk, Marielle, Jennings, Emma L M, Dalleur, Olivia, Mavridis, Dimitris, and Knol, Wilma

Subjects
10. No inequality, 610 Medicine & health, 360 Social problems & social services, 3. Good health
Abstract

OBJECTIVE To assess the efficacy of medication review as an isolated intervention and with several co-interventions for preventing hospital readmissions in older adults. METHODS Ovid MEDLINE, Embase, The Cochrane Central Register of Controlled Trials and CINAHL were searched for randomized controlled trials evaluating the effectiveness of medication review interventions with or without co-interventions to prevent hospital readmissions in hospitalized or recently discharged adults aged ≥65, until September 13, 2019. Included outcomes were "at least one all-cause hospital readmission within 30 days and at any time after discharge from the index admission." RESULTS Twenty-five studies met the inclusion criteria. Of these, 11 studies (7,318 participants) contributed to the network meta-analysis (NMA) on all-cause hospital readmission within 30 days. Medication review in combination with (a) medication reconciliation and patient education (risk ratio (RR) 0.45; 95% confidence interval (CI) 0.26-0.80) and (b) medication reconciliation, patient education, professional education and transitional care (RR 0.64; 95% CI 0.49-0.84) were associated with a lower risk of all-cause hospital readmission compared to usual care. Medication review in isolation did not significantly influence hospital readmissions (RR 1.06; 95% CI 0.45-2.51). The NMA on all-cause hospital readmission at any time included 24 studies (11,677 participants). Medication review combined with medication reconciliation, patient education, professional education and transitional care resulted in a reduction of hospital readmissions (RR 0.82; 95% CI 0.74-0.91) compared to usual care. The quality of the studies included in this systematic review raised some concerns, mainly regarding allocation concealment, blinding and contamination. CONCLUSION Medication review in combination with medication reconciliation, patient education, professional education and transitional care, was associated with a lower risk of hospital readmissions compared to usual care. An effect of medication review without co-interventions was not demonstrated. Trials of higher quality are needed in this field.

14. [Controversies concerning screening and treatment of primary dyslipidemias in 2020].

Author

Bretagne L, Aubert C, Nanchen D, and Rodondi N

Subjects
Cholesterol, LDL blood, Dyslipidemias blood, Dyslipidemias genetics, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Quality of Life, Risk Factors, Dyslipidemias diagnosis, Dyslipidemias therapy
Abstract

Familial dyslipidemia is rare compared to polygenetic causes. Nevertheless, it is important not to miss this diagnosis, as it is more strongly associated with an increased risk of early cardiovascular disease and scores for calculating cardiovascular risk are not valid in this population. Early detection and management based on lifestyle optimization and treatment of cardiovascular risk factors can delay the onset of cardiovascular complications and thus improve patients' quality of life. A LDL-Cholesterol of 4,9 mmol/l has recently been suggested as the cut-off for starting lipid lowering therapy, but remains controversial because the majority of people above this threshold do not have primary monogenic dyslipidemia. The age at which therapy should be initiated as well as the targets for treatment are also controversial., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article. Le Dr David Nanchen est soutenu par la Fondation suisse de cardiologie pour réaliser une étude de dépistage en cascade de l’hypercholestérolémie familiale.

Published
2020

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