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1. Asbestos exposure and asbestosis mortality in Italian cement‐asbestos cohorts: Dose‐response relationship and the role of competing death causes.

Author

Girardi, Paolo, Rigoni, Sara, Ferrante, Daniela, Silvestri, Stefano, Angelini, Alessia, Cuccaro, Francesco, Oddone, Enrico, Vicentini, Massimo, Barone‐Adesi, Francesco, Tunesi, Sara, Migliore, Enrica, Roncaglia, Francesca, Sala, Orietta, Pirastu, Roberta, Chellini, Elisabetta, Miligi, Lucia, Perticaroli, Patrizia, Bressan, Vittoria, Merler, Enzo, and Azzolina, Danila

Subjects
HEALTH risk assessment, PERITONEAL cancer, CARDIOVASCULAR system, ASBESTOS, CAUSES of death
Abstract

Objectives: In Italy, asbestos was used intensively until its ban in 1992, which was extended for asbestos cement factories until 1994. The aim of this study was to evaluate the dose–response between asbestos exposure and asbestosis mortality across a pool of Italian occupational cohorts, taking into account the presence of competing risks. Methods: Cohorts were followed for vital status and the cause of death was ascertained by a linkage with mortality registers. Cause‐specific (CS) Cox‐regression models were used to evaluate the dose‐exposure relationship between asbestosis mortality and the time‐dependent cumulative exposure index (CEI) to asbestos. Fine and Gray regression models were computed to assess the effect of competing risks of death. Results: The cohort included 12,963 asbestos cement workers. During the follow‐up period (1960−2012), of a total of 6961 deaths, we observed 416 deaths attributed to asbestosis, 879 to lung cancer, 400 to primary pleural cancer, 135 to peritoneal cancer, and 1825 to diseases of the circulatory system. The CS model showed a strong association between CEI and asbestosis mortality. Dose–response models estimated an increasing trend in mortality even below a CEI of 25 ff/mL‐years. Lung cancer and circulatory diseases were the main competing causes of death. Conclusions: Asbestos exposure among Italian asbestos‐cement workers has led to a very high number of deaths from asbestosis and asbestos‐related diseases. The increasing risk trend associated with excess deaths, even at low exposure levels, suggests that the proposed limit values would not have been adequate to prevent disability and mortality from asbestosis. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer : a pooled analysis of cohort studies

Author

Working Group, Barone-Adesi, Francesco, Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Curti, Stefania, Baldassarre, Antonio, Cena, Tiziana, Angelini, Alessia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, and Magnani, Corrado

Published
2019

4. Italian pool of asbestos workers cohorts : mortality trends of asbestos-related neoplasms after long time since first exposure

Author

Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Mattioli, Stefano, Baldassarre, Antonio, Barone-Adesi, Francesco, Cena, Tiziana, Legittimo, Patrizia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, and Magnani, Corrado

Published
2017

5. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

Author

Luberto, Ferdinando, Ferrante, Daniela, Silvestri, Stefano, Angelini, Alessia, Cuccaro, Francesco, Nannavecchia, Anna Maria, Oddone, Enrico, Vicentini, Massimo, Barone-Adesi, Francesco, Cena, Tiziana, Mirabelli, Dario, Mangone, Lucia, Roncaglia, Francesca, Sala, Orietta, Menegozzo, Simona, Pirastu, Roberta, Azzolina, Danila, Tunesi, Sara, Chellini, Elisabetta, Miligi, Lucia, Perticaroli, Patrizia, Pettinari, Aldo, Bressan, Vittoria, Merler, Enzo, Girardi, Paolo, Bisceglia, Lucia, Marinaccio, Alessandro, Massari, Stefania, Magnani, Corrado, and the working group

Published
2019
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6. Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

Author

Azzolina, Danila, primary, Consonni, Dario, additional, Ferrante, Daniela, additional, Mirabelli, Dario, additional, Silvestri, Stefano, additional, Luberto, Ferdinando, additional, Angelini, Alessia, additional, Cuccaro, Francesco, additional, Nannavecchia, Anna Maria, additional, Oddone, Enrico, additional, Vicentini, Massimo, additional, Barone-Adesi, Francesco, additional, Cena, Tiziana, additional, Mangone, Lucia, additional, Roncaglia, Francesca, additional, Sala, Orietta, additional, Menegozzo, Simona, additional, Pirastu, Roberta, additional, Tunesi, Sara, additional, Chellini, Elisabetta, additional, Miligi, Lucia, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Bressan, Vittoria, additional, Merler, Enzo, additional, Girardi, Paolo, additional, Bisceglia, Lucia, additional, Marinaccio, Alessandro, additional, Massari, Stefania, additional, and Magnani, Corrado, additional

Published
2022
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8. A Retrospective Cohort Study of Young Women Spontaneously Choosing to Be Vaccinated against HPV: Outcomes from Their First Cervical Cancer Screening Test

Author

Mistro, Annarosa Del, Battagello, Jessica, Weis, Luca, Bressan, Vittoria, Selle, Vittorio, Ramigni, Mauro, Zotto, Alessandra Dal, Maggiolo, Antonio, Gori, Silvia, Frayle, Helena, Zappa, Marco, Zorzi, Manuel, and Group, the Consensus Study Veneto Working

Subjects
HPV, CIN2, prevention, prophylactic vaccination, CIN3, parasitic diseases, cervical cancer screening, lcsh:QR1-502, age at vaccination, cancer, lcsh:Microbiology
Abstract

Background: Efficacy for cervical cancer prevention of opportunistic HPV vaccination in post-pubertal girls is lower than in 11-year-olds. Methods: Women born between 1986 and 1992 vaccinated at 15–25 years of age (at least one dose of 4-valent HPV vaccine) and screened at 24–27 years of age were included. Frequency of opportunistic vaccination, overall and by birth cohort, was calculated, screening outcomes were compared between vaccinated and unvaccinated women. Results: Overall, 4718 (4.9%) HPV-vaccinated, and 91,512 unvaccinated, women were studied. The frequency of vaccination increased by birth cohort, ranging between 1.8% and 9.8%, age at vaccination decreased progressively by birth cohort (p &lt, 0.0001). Participation in screening was 60.8% among vaccinated, and 56.6% among unvaccinated, women (p &lt, 0.0001). Detection rates (DR) for high-grade lesions were lower in vaccinated women (2.11‰ vs. 3.85‰ in unvaccinated, for CIN3+, p = 0.24, 0.0‰ vs. 0.22‰ for cancer). The DR of CIN3+ increased with age at vaccination, scoring respectively 0.0‰, 0.83‰, and 4.68‰ for women vaccinated when they were 15–16, 17–20, and 21–25 years old (p = 0.17). Conclusions: In comparison to unvaccinated women, higher compliance with cervical cancer screening invitation and lower CIN3+ DR among vaccinated women was observed. Age at vaccination was inversely correlated to vaccination efficacy.

Published
2021

9. A retrospective cohort study of young women spontaneously choosing to be vaccinated against hpv: Outcomes from their first cervical cancer screening test

Author

Del Mistro, Annarosa, Battagello, Jessica, Weis, Luca, Bressan, Vittoria, Selle, Vittorio, Ramigni, Mauro, Dal Zotto, Alessandra, Maggiolo, Antonio, Gori, Silvia, Frayle, Helena, Zappa, Marco, and Zorzi, Manuel

Subjects
Adult, HPV, CIN2, Adolescent, CIN3, Prevention, Papillomavirus Infections, Uterine Cervical Neoplasms, Age at vaccination, Cancer, Cervical cancer screening, Prophylactic vaccination, Early Detection of Cancer, Female, Humans, Italy, Mass Screening, Papillomavirus Vaccines, Retrospective Studies, Young Adult, Article
Abstract

Background: Efficacy for cervical cancer prevention of opportunistic HPV vaccination in post-pubertal girls is lower than in 11-year-olds. Methods: Women born between 1986 and 1992 vaccinated at 15–25 years of age (at least one dose of 4-valent HPV vaccine) and screened at 24–27 years of age were included. Frequency of opportunistic vaccination, overall and by birth cohort, was calculated; screening outcomes were compared between vaccinated and unvaccinated women. Results: Overall, 4718 (4.9%) HPV-vaccinated, and 91,512 unvaccinated, women were studied. The frequency of vaccination increased by birth cohort, ranging between 1.8% and 9.8%; age at vaccination decreased progressively by birth cohort (p < 0.0001). Participation in screening was 60.8% among vaccinated, and 56.6% among unvaccinated, women (p < 0.0001). Detection rates (DR) for high-grade lesions were lower in vaccinated women (2.11‰ vs. 3.85‰ in unvaccinated, for CIN3+, p = 0.24; 0.0‰ vs. 0.22‰ for cancer). The DR of CIN3+ increased with age at vaccination, scoring respectively 0.0‰, 0.83‰, and 4.68‰ for women vaccinated when they were 15–16, 17–20, and 21–25 years old (p = 0.17). Conclusions: In comparison to unvaccinated women, higher compliance with cervical cancer screening invitation and lower CIN3+ DR among vaccinated women was observed. Age at vaccination was inversely correlated to vaccination efficacy.

Published
2021

10. Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers

Author

Azzolina, Danila, Consonni, Dario, Ferrante, Daniela, Mirabelli, Dario, Silvestri, Stefano, Luberto, Ferdinando, Angelini, Alessia, Cuccaro, Francesco, Nannavecchia, Anna Maria, Oddone, Enrico, Vicentini, Massimo, Barone-Adesi, Francesco, Cena, Tiziana, Mangone, Lucia, Roncaglia, Francesca, Sala, Orietta, Menegozzo, Simona, Pirastu, Roberta, Tunesi, Sara, Chellini, Elisabetta, Miligi, Lucia, Perticaroli, Patrizia, Pettinari, Aldo, Bressan, Vittoria, Merler, Enzo, Girardi, Paolo, Bisceglia, Lucia, Marinaccio, Alessandro, Massari, Stefania, and Magnani, Corrado

Abstract

IntroductionExposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy.MethodThe cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE).ResultAcceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE.ConclusionThe current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality.

Published
2023
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11. Additional file 1: of Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy

Author

Luberto, Ferdinando, Ferrante, Daniela, Silvestri, Stefano, Angelini, Alessia, Cuccaro, Francesco, Nannavecchia, Anna, Oddone, Enrico, Vicentini, Massimo, Barone-Adesi, Francesco, Cena, Tiziana, Mirabelli, Dario, Mangone, Lucia, Roncaglia, Francesca, Sala, Orietta, Menegozzo, Simona, Pirastu, Roberta, Azzolina, Danila, Tunesi, Sara, Chellini, Elisabetta, Miligi, Lucia, Perticaroli, Patrizia, Pettinari, Aldo, Bressan, Vittoria, Merler, Enzo, Girardi, Paolo, Bisceglia, Lucia, Marinaccio, Alessandro, Massari, Stefania, and Magnani, Corrado

Abstract

Table S1. Asbestos cement pooled Italian study. Summary of cohort data, including all subjects, including those with follow-up terminated before 1970. Table S2. Asbestos cement pooled Italian study. Cause of death codes according to ICD in use at the date of death. Table S3. Asbestos cement pooled Italian study. Average asbestos exposure index, crude and adjusted for carcinogenic potency of asbestos types used, by cohort. Table S4. Asbestos cement pooled Italian study. Person-years at risk by gender and age class. Table S5. Asbestos cement pooled Italian study. Mortality by gender and duration of employment for selected causes of death. Table S6. Asbestos cement pooled Italian study. Mortality by gender and period of first exposure for selected causes of death. (PDF 646 kb)

Published
2019
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12. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies

Author

Barone-Adesi, Francesco, primary, Ferrante, Daniela, additional, Chellini, Elisabetta, additional, Merler, Enzo, additional, Pavone, Venere, additional, Silvestri, Stefano, additional, Miligi, Lucia, additional, Gorini, Giuseppe, additional, Bressan, Vittoria, additional, Girardi, Paolo, additional, Ancona, Laura, additional, Romeo, Elisa, additional, Luberto, Ferdinando, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Menegozzo, Simona, additional, Oddone, Enrico, additional, Tunesi, Sara, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Cuccaro, Francesco, additional, Curti, Stefania, additional, Baldassarre, Antonio, additional, Cena, Tiziana, additional, Angelini, Alessia, additional, Marinaccio, Alessandro, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, and Magnani, Corrado, additional

Published
2019
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13. Valutazione della variazione temporale del rischio di mesotelioma e di tumore del polmone nelle coorti di esposti ad amianto per lavoro in Italia

Author

Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Luberto, Ferdinando, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, Silvestri, Stefano, Curti, Stefania, Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Luberto, Ferdinando, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, Silvestri, Stefano, [.., Curti, Stefania, and ]

Subjects
Male, Mesothelioma, Lung Neoplasms, Epidemiology, Environmental and Occupational Health, Asbestosi, Public Health, Environmental and Occupational Health, Socio-culturale, Ambientale, Asbesto, Asbestos, Occupational Disease, Lung Neoplasm, Occupational Diseases, Economica, Italy, Occupational Exposure, Asbestosis, Humans, Female, Public Health, Human
Abstract

This study aims at investigating, in asbestos exposed workers, the time trend of their risk of mesothelioma and of other neoplasm after very long latency and after the cessation of asbestos exposure. We pooled a large number of Italian cohorts of asbestos workers and updated mortality follow-up. The pool of data for statistical analyses includes 51,988 workers, of which 6,058 women: 54.2% was alive at follow-up, 42.6% was dead, and 2.8%was lost. Cause of death is known for 94.3%: 2,548 deaths from lung cancer, 748 frompleural cancer, 173 fromperitoneal cancer, and 434 from asbestosis. An exposure index is being developed to compare the different cohorts. Data analysis is in progress. This study will have the size for analysing not only time trends in mesothelioma, but also the occurrence of rarer diseases and cancer specific mortality in women.

Published
2016

14. Migration and work in postwar Australia: mortality profile comparisons between Australian and Italian workers exposed to blue asbestos at Wittenoom

Author

One Health Chemisch, Reid, Alison, Merler, Enzo, Peters, Susan, Jayasinghe, Nimashi, Bressan, Vittoria, Franklin, Peter, Brims, Fraser, de Klerk, Nicholas H, Musk, Arthur W, One Health Chemisch, Reid, Alison, Merler, Enzo, Peters, Susan, Jayasinghe, Nimashi, Bressan, Vittoria, Franklin, Peter, Brims, Fraser, de Klerk, Nicholas H, and Musk, Arthur W

Published
2018

15. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure.

Author

Magnani, Corrado, Silvestri, Stefano, Angelini, Alessia, Ranucci, Alessandra, Azzolina, Danila, Cena, Tiziana, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Bauleo, Lisa, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, and Oddone, Enrico

Published
2020
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16. [Increased risk of mesothelioma and lung cancer among workers exposed to asbestos who could require an anticipated retirement]

Author

Merler, Enzo, Girardi, Paolo, Panato, Chiara, and Bressan, Vittoria

Subjects
asbestos, occupational exposure, mesothelioma, lung cancer, cohort study, Mesothelioma, lung cancer, Retirement, Lung Neoplasms, Italy, Occupational Exposure, Pleural Neoplasms, cohort study, Humans, Asbestos, Settore MED/01 - Statistica Medica
Abstract

to assess the association among malignant pleural mesothelioma (MPM) and lung cancer (LC) among workers who have been exposed to asbestos and have or not have required an anticipated leave from work, a possibility offered by the 1992 law banning asbestos in Italy, in the framework of the health surveillance programmes on going in the Veneto Region (Northern Italy).a cohort of asbestos workers derived from the rosters of selected factories and alive in 1992, followed from 1992 to 2012.MPM cases have been identified through the Regional Mesothelioma Registry, while LC cases through a link with the Regional Cancer Registry, hospital discharges, and death certificates. Risks related to asbestos exposure were calculated by mixed effects Poisson regression model.the risk of MPM and LC increases at any additional duration of work, up to very high values for long term durations of work for MPM, and up to a three fold increase for LC. Early retirements have been requested by a fraction only in the position of submitting it.subjects who have been exposed to asbestos should be the target of a post-occupational surveillance, and further work is suggested to identify subjects at high risk of LC because of smoking habits and more heavy exposure to asbestos, in order to develop programmes for primary and secondary cancer prevention.

Published
2016

18. O32-3 A pooled cohort study on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer

Author

Magnani, Corrado, primary, Barone-Adesi, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tizian, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and W, G, additional

Published
2016
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19. A pooled cohort analysis on cancer risk among former asbestos-exposed workers: role of asbestos clearance in explaining long-term mortality trend for pleural cancer.

Author

Magnani, Corrado, primary, Barone-Adesi*, Francesco, additional, Ferrante, Daniela, additional, Ancona, Laura, additional, Baldassarre, Antonio, additional, Bressan, Vittoria, additional, Cena, Tiziana, additional, Chellini, Elisabetta, additional, Cuccaro, Francesco, additional, Legittimo, Patrizia, additional, Luberto, Ferdinando, additional, Marinaccio, Alessandro, additional, Mattioli, Stefano, additional, Menegozzo, Simona, additional, Merler, Enzo, additional, Miligi, Lucia, additional, Mirabelli, Dario, additional, Musti, Marina, additional, Oddone, Enrico, additional, Pavone, Venere, additional, Perticaroli, Patrizia, additional, Pettinari, Aldo, additional, Pirastu, Roberta, additional, Ranucci, Alessandra, additional, Romeo, Elisa, additional, Sala, Orietta, additional, Scarnato, Corrado, additional, Silvestri, Stefano, additional, and Group, Working, additional

Published
2016
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21. Time trend in mesothelioma and lung cancer risk in asbestos workers in Italy

Author

Magnani, Corrado, Ancona, Laura, Baldassarre, Antonio, Bressan, Vittoria, Cena, Tiziana, Chellini, Elisabetta, Cuccaro, Francesco, Ferrante, Daniela, Legittimo, Patrizia, Ferdinando Luberto, Marinaccio, Alessandro, Mattioli, Stefano, Menegozzo, Simona, Merler, Enzo, Miligi, Lucia, Mirabelli, Dario, Musti, Marina, Oddone, Enrico, Pavone, Venere, Perticaroli, Patrizia, Pettinari, Aldo, Pirastu, Roberta, Ranucci, Alessandra, Romeo, Elisa, Sala, Orietta, Scarnato, Corrado, and Silvestri, Stefano

22. Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

Author

Nijbroek, Sunny G, Hol, Liselotte, Swart, Pien, Hemmes, Sabrine N T, Serpa Neto, Ary, Binnekade, Jan M, Hedenstierna, Goran, Jaber, Samir, Hiesmayr, Michael, Hollmann, Markus W, Mills, Gary H, Vidal Melo, Marcos F, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Wrigge, Hermann, Gama de Abreu, Marcelo, Pelosi, Paolo, Schultz, Marcus J, Wolfgang Kroell, Helfried Metzler, Gerd Struber, Thomas Wegscheider, Hans Gombotz, Michael Hiesmayr, Werner Schmid, Bernhard Urbanek, David Kahn, Mona Momeni, Audrey Pospiech, Fernande Lois, Patrice Forget, Irina Grosu, Jan Poelaert, Veerle van Mossevelde, Marie-Claire van Malderen, Dimitri Dylst, Jeroen van Melkebeek, Maud Beran, Stefan de Hert, Luc De Baerdemaeker, Bjorn Heyse, Jurgen Van Limmen, Piet Wyffels, Tom Jacobs, Nathalie Roels, Ann De Bruyne, Stijn van de Velde, Brigitte Leva, Sandrine Damster, Benoit Plichon, Marina Juros-Zovko, Dejana Djonoviċ- Omanoviċ, Selma Pernar, Josip Zunic, Petar Miskovic, Antonio Zilic, Slavica Kvolik, Dubravka Ivic, Darija Azenic-Venzera, Sonja Skiljic, Hrvoje Vinkovic, Ivana Oputric, Kazimir Juricic, Vedran Frkovic, Jasminka Kopic, Ivan Mirkovic, Nenad Karanovic, Mladen Carev, Natasa Dropulic, Jadranka Pavicic Saric, Gorjana Erceg, Matea Bogdanovic Dvorscak, Branka Mazul-Sunko, Anna Marija Pavicic, Tanja Goranovic, Branka Maldini, Tomislav Radocaj, Zeljka Gavranovic, Inga Mladic-Batinica, Mirna Sehovic, Petr Stourac, Hana Harazim, Olga Smekalova, Martina Kosinova, Tomas Kolacek, Kamil Hudacek, Michal Drab, Jan Brujevic, Katerina Vitkova, Katerina Jirmanova, Ivana Volfova, Paula Dzurnakova, Katarina Liskova, Radovan Dudas, Radek Filipsky, Samir el Kafraw, Hisham Hosny Abdelwahab, Tarek Metwally, Ahmed Abdel-Razek, Ahmed Mostafa El-Shaarawy, Hany Yassin, Mohamed Magdy, Mahdy Abdelhady, Mohamed Mahran, Eiko Herodes, Peeter Kivik, Juri Oganjan, Annika Aun, Alar Sormus, Kaili Sarapuu, Merilin Mall, Juri Karjagin, Emmanuel Futier, Antoine Petit, Adeline Gerard, Emmanuel Marret, Marc Solier, Samir Jaber, Albert Prades, Jens Krassler, Simone Merzky, Marcel Gama de Abreu, Christopher Uhlig, Thomas Kiss, Anette Bundy, Thomas Bluth, Andreas Gueldner, Peter Spieth, Martin Scharffenberg, Denny Tran Thiem, Thea Koch, Tanja Treschan, Maximilian Schaefer, Bea Bastin, Johann Geib, Martin Weiss, Peter Kienbaum, Benedikt Pannen, Andre Gottschalk, Mirja Konrad, Diana Westerheide, Ben Schwerdtfeger, Hermann Wrigge, Philipp Simon, Andreas Reske, Christian Nestler, Dimitrios Valsamidis, Konstantinos Stroumpoulis, Georgios Antholopoulos, Antonis Andreou, Dimitris Karapanos, Kassiani Theodoraki, Georgios Gkiokas, Marios-Konstantinos Tasoulis, Tatiana Sidiropoulou, Foteini Zafeiropoulou, Panagiota Florou, Aggeliki Pandazi, Georgia Tsaousi, Christos Nouris, Chryssa Pourzitaki, Dmitri Bystritski, Reuven Pizov, Arieh Eden, Caterina Valeria Pesce, Annamaria Campanile, Antonella Marrella, Salvatore Grasso, Michele De Michele, Francesco Bona, Gianmarco Giacoletto, Elena Sardo, Luigi Giancarlo, Vicari Sottosanti, Maurizio Solca, Carlo Alberto Volta, Savino Spadaro, Marco Verri, Riccardo Ragazzi, Roberto Zoppellari, Gilda Cinnella, Pasquale Raimondo, Daniela La Bella, Lucia Mirabella, Davide D'antini, Paolo Pelosi, Alexandre Molin, Iole Brunetti, Angelo Gratarola, Giulia Pellerano, Rosanna Sileo, Stefano Pezzatto, Luca Montagnani, Laura Pasin, Giovanni Landoni, Alberto Zangrillo, Luigi Beretta, Ambra Licia Di Parma, Valentina Tarzia, Roberto Dossi, Marta Eugenia Sassone, Daniele Sances, Stefano Tredici, Gianluca Spano, Gianluca Castellani, Luigi Delunas, Sopio Peradze, Marco Venturino, Ines Arpino, Sara Sher, Concezione Tommasino, Francesca Rapido, Paola Morelli, Maria Vargas, Giuseppe Servillo, Andrea Cortegiani, Santi Maurizio Raineri, Francesca Montalto, Vincenzo Russotto, Antonino Giarratano, Marco Baciarello, Michela Generali, Giorgia Cerati, Yigal Leykin, Filippo Bressan, Vittoria Bartolini, Lucia Zamidei, Luca Brazzi, Corrado Liperi, Gabriele Sales, Laura Pistidda, Paolo Severgnini, Elisa Brugnoni, Giuseppe Musella, Alessandro Bacuzzi, Dalip Muhardri, Gecaj-Gashi Agreta, Fatos Sada, Adem Bytyqi, Aurika Karbonskiene, Ruta Aukstakalniene, Zivile Teberaite, Erika Salciute, Renatas Tikuisis, Povilas Miliauskas, Sipylaite Jurate, Egle Kontrimaviciute, Gabija Tomkute, John Xuereb, Maureen Bezzina, Francis Joseph Borg, Sabrine Hemmes, Marcus Schultz, Markus Hollmann, Irene Wiersma, Christa Boer, Anne Duvekot, Bas in ‘t Veld, Alice Werger, Paul Dennesen, Charlotte Severijns, Jasper De Jong, Jens Hering, Rienk van Beek, Stefan Ivars, Ib Jammer, Alena Breidablik, Katharina Skirstad Hodt, Frode Fjellanger, Manuel Vico Avalos, Jannicke Mellin-Olsen, Elisabeth Andersson, Amir Shafi-Kabir, Ruby Molina, Stanley Wutai, Erick Morais, Glória Tareco, Daniel Ferreira, Joana Amaral, Maria de Lurdes, Goncalves Castro, Susana Cadilha, Sofia Appleton, Suzana Parente, Mariana Correia, Diogo Martins, Angela Monteirosa, Ana Ricardo, Sara Rodrigues, Lucian Horhota, Ioana Marina Grintescu, Liliana Mirea, Ioana Cristina Grintescu, Dan Corneci, Silvius Negoita, Madalina Dutu, Ioana Popescu Garotescu, Daniela Filipescu, Alexandru Bogdan Prodan, Gabriela Droc, Ruxandra Fota, Mihai Popescu, Dana Tomescu, Ana Maria Petcu, Marian Irinel Tudoroiu, Alida Moise, Catalin-Traian Guran, Iorel Gherghina, Dan Costea, Iulia Cindea, Sanda-Maria Copotoiu, Ruxandra Copotoiu, Victoria Barsan, Zsolt Tolcser, Magda Riciu, Septimiu Gheorghe Moldovan, Mihaly Veres, Alexey Gritsan, Tatyana Kapkan, Galina Gritsan, Oleg Korolkov, Alexander Kulikov, Andrey Lubnin, Alexey Ovezov, Pavel Prokoshev, Alexander Lugovoy, Natalia Anipchenko, Andrey Babayants, Irina Komissarova, Karginova Zalina, Valery Likhvantsev, Sergei Fedorov, Aleksandra Lazukic, Jasmina Pejakovic, Dunja Mihajlovic, Zuzana Kusnierikova, Maria Zelinkova, Katarina Bruncakova, Lenka Polakovicova, Villiam Sobona, Barbka Novak-Supe, Ana Pekle-Golez, Miroljub Jovanov, Branka Strazisar, Jasmina Markovic-Bozi, Vesna Novak-Jankovic, Minca Voje, Andriy Grynyuk, Ivan Kostadinov, Alenka Spindler-Vesel, Victoria Moral, Mari Carmen Unzueta, Carlos Puigbo, Josep Fava, Jaume Canet, Enrique Moret, Mónica Rodriguez Nunez, Mar Sendra, Andrea Brunelli, Frederic Rodenas, Pablo Monedero, Francisco Hidalgo Martinez, Maria Jose Yepes Temino, Antonio Martínez Simon, Ana de Abajo Larriba, Alberto Lisi, Gisela Perez, Raquel Martinez, Manuel Granell, Jose Tatay Vivo, Cristina Saiz Ruiz, Jose Antonio de Andrés Ibañez, Ernesto Pastor, Marina Soro, Carlos Ferrando, Mario Defez, Cesar Aldecoa Alvares-Santullano, Rocio Perez, Jesus Rico, Monir Jawad, Yousif Saeed, Lars Gillberg, Zuleyha Kazak Bengisun, Baturay Kansu Kazbek, Nesil Coskunfirat, Neval Boztug, Suat Sanli, Murat Yilmaz, Necmiye Hadimioglu, Nuzhet Mert Senturk, Emre Camci, Semra Kucukgoncu, Zerrin Sungur, Nukhet Sivrikoz, Serpil Ustalar Ozgen, Fevzi Toraman, Onur Selvi, Ozgur Senturk, Mine Yildiz, Bahar Kuvaki, Ferim Gunenc, Semih Kucukguclu, Şule Ozbilgin, Jale Maral, Seyda Canli, Oguzhan Arun, Ali Saltali, Eyup Aydogan, Fatma Nur Akgun, Ceren Sanlikarip, Fatma Mine Karaman, Andriy Mazur, Sergiy Vorotyntsev, Guy Rousseau, Colin Barrett, Lucia Stancombe, Ben Shelley, Helen Scholes, James Limb, Amir Rafi, Lisa Wayman, Jill Deane, David Rogerson, John Williams, Susan Yates, Elaine Rogers, Mark Pulletz, Sarah Moreton, Stephanie Jones, Suresh Venkatesh, Maudrian Burton, Lucy Brown, Cait Goodall, Matthew Rucklidge, Debbie Fuller, Maria Nadolski, Sandeep Kusre, Michael Lundberg, Lynn Everett, Maka Zuleika, Peter Carvalho, Deborah Clements, Ben Creagh-Brown, Philip Watt, Parizade Raymode, Rupert Pearse, Otto Mohr, Ashok Raj, Thais Creary, Ahmed Chishti, Andrea Bell, Charley Higham, Alistair Cain, Sarah Gibb, Stephen Mowat, Danielle Franklin, Claire West, Gary Minto, Nicholas Boyd, Gary Mills, Emily Calton, Rachel Walker, Felicity Mackenzie, Branwen Ellison, Helen Roberts, Moses Chikungwa, Clare Jackson, Andrew Donovan, Jayne Foot, Elizabeth Homan, Jane Montgomery, David Portch, Pauline Mercer, Janet Palmer, Jonathan Paddle, Anna Fouracres, Amanda Datson, Alyson Andrew, Leanne Welch, Alastair Rose, Sandeep Varma, Karen Simeson, Mrutyunjaya Rambhatla, Jaysimha Susarla, Sudhakar Marri, Krishnan Kodaganallur, Ashok Das, Shivarajan Algarsamy, Julie Colley, Simon Davies, Margaret Szewczyk, Thomas Smith, Ana Fernandez- Bustamante, Elizabeth Luzier, Angela Almagro, Marcos Vidal Melo, Luiz Fernando, Demet Sulemanji, Juraj Sprung, Toby Weingarten, Daryl Kor, Federica Scavonetto, Yeo Tze, Nijbroek, Sunny G, Hol, Liselotte, Swart, Pien, Hemmes, Sabrine N T, Serpa Neto, Ary, Binnekade, Jan M, Hedenstierna, Goran, Jaber, Samir, Hiesmayr, Michael, Hollmann, Markus W, Mills, Gary H, Vidal Melo, Marcos F, Putensen, Christian, Schmid, Werner, Severgnini, Paolo, Wrigge, Hermann, Gama de Abreu, Marcelo, Pelosi, Paolo, Schultz, Marcus J,Wolfgang Kroell, Helfried Metzler, Gerd Struber, Thomas Wegscheider, Hans Gombotz, Michael Hiesmayr, Werner Schmid, Bernhard Urbanek, David Kahn, Mona Momeni, Audrey Pospiech, Fernande Lois, Patrice Forget, Irina Grosu, Jan Poelaert, Veerle van Mossevelde, Marie-Claire van Malderen, Dimitri Dylst, Jeroen van Melkebeek, Maud Beran, Stefan de Hert, Luc De Baerdemaeker, Bjorn Heyse, Jurgen Van Limmen, Piet Wyffels, Tom Jacobs, Nathalie Roels, Ann De Bruyne, Stijn van de Velde, Brigitte Leva, Sandrine Damster, Benoit Plichon, Marina Juros-Zovko, Dejana Djonoviċ- Omanoviċ, Selma Pernar, Josip Zunic, Petar Miskovic, Antonio Zilic, Slavica Kvolik, Dubravka Ivic, Darija Azenic-Venzera, Sonja Skiljic, Hrvoje Vinkovic, Ivana Oputric, Kazimir Juricic, Vedran Frkovic, Jasminka Kopic, Ivan Mirkovic, Nenad Karanovic, Mladen Carev, Natasa Dropulic, Jadranka Pavicic Saric, Gorjana Erceg, Matea Bogdanovic Dvorscak, Branka Mazul-Sunko, Anna Marija Pavicic, Tanja Goranovic, Branka Maldini, Tomislav Radocaj, Zeljka Gavranovic, Inga Mladic-Batinica, Mirna Sehovic, Petr Stourac, Hana Harazim, Olga Smekalova, Martina Kosinova, Tomas Kolacek, Kamil Hudacek, Michal Drab, Jan Brujevic, Katerina Vitkova, Katerina Jirmanova, Ivana Volfova, Paula Dzurnakova, Katarina Liskova, Radovan Dudas, Radek Filipsky, Samir el Kafraw, Hisham Hosny Abdelwahab, Tarek Metwally, Ahmed Abdel-Razek, Ahmed Mostafa El-Shaarawy, Hany Yassin, Mohamed Magdy, Mahdy Abdelhady, Mohamed Mahran, Eiko Herodes, Peeter Kivik, Juri Oganjan, Annika Aun, Alar Sormus, Kaili Sarapuu, Merilin Mall, Juri Karjagin, Emmanuel Futier, Antoine Petit, Adeline Gerard, Emmanuel Marret, Marc Solier, Samir Jaber, Albert Prades, Jens Krassler, Simone Merzky, Marcel Gama de Abreu, Christopher Uhlig, Thomas Kiss, Anette Bundy, Thomas Bluth, Andreas Gueldner, Peter Spieth, Martin Scharffenberg, Denny Tran Thiem, Thea Koch, Tanja Treschan, Maximilian Schaefer, Bea Bastin, Johann Geib, Martin Weiss, Peter Kienbaum, Benedikt Pannen, Andre Gottschalk, Mirja Konrad, Diana Westerheide, Ben Schwerdtfeger, Hermann Wrigge, Philipp Simon, Andreas Reske, Christian Nestler, Dimitrios Valsamidis, Konstantinos Stroumpoulis, Georgios Antholopoulos, Antonis Andreou, Dimitris Karapanos, Kassiani Theodoraki, Georgios Gkiokas, Marios-Konstantinos Tasoulis, Tatiana Sidiropoulou, Foteini Zafeiropoulou, Panagiota Florou, Aggeliki Pandazi, Georgia Tsaousi, Christos Nouris, Chryssa Pourzitaki, Dmitri Bystritski, Reuven Pizov, Arieh Eden, Caterina Valeria Pesce, Annamaria Campanile, Antonella Marrella, Salvatore Grasso, Michele De Michele, Francesco Bona, Gianmarco Giacoletto, Elena Sardo, Luigi Giancarlo, Vicari Sottosanti, Maurizio Solca, Carlo Alberto Volta, Savino Spadaro, Marco Verri, Riccardo Ragazzi, Roberto Zoppellari, Gilda Cinnella, Pasquale Raimondo, Daniela La Bella, Lucia Mirabella, Davide D'antini, Paolo Pelosi, Alexandre Molin, Iole Brunetti, Angelo Gratarola, Giulia Pellerano, Rosanna Sileo, Stefano Pezzatto, Luca Montagnani, Laura Pasin, Giovanni Landoni, Alberto Zangrillo, Luigi Beretta, Ambra Licia Di Parma, Valentina Tarzia, Roberto Dossi, Marta Eugenia Sassone, Daniele Sances, Stefano Tredici, Gianluca Spano, Gianluca Castellani, Luigi Delunas, Sopio Peradze, Marco Venturino, Ines Arpino, Sara Sher, Concezione Tommasino, Francesca Rapido, Paola Morelli, Maria Vargas, Giuseppe Servillo, Andrea Cortegiani, Santi Maurizio Raineri, Francesca Montalto, Vincenzo Russotto, Antonino Giarratano, Marco Baciarello, Michela Generali, Giorgia Cerati, Yigal Leykin, Filippo Bressan, Vittoria Bartolini, Lucia Zamidei, Luca Brazzi, Corrado Liperi, Gabriele Sales, Laura Pistidda, Paolo Severgnini, Elisa Brugnoni, Giuseppe Musella, Alessandro Bacuzzi, Dalip Muhardri, Gecaj-Gashi Agreta, Fatos Sada, Adem Bytyqi, Aurika Karbonskiene, Ruta Aukstakalniene, Zivile Teberaite, Erika Salciute, Renatas Tikuisis, Povilas Miliauskas, Sipylaite Jurate, Egle Kontrimaviciute, Gabija Tomkute, John Xuereb, Maureen Bezzina, Francis Joseph Borg, Sabrine Hemmes, Marcus Schultz, Markus Hollmann, Irene Wiersma, Christa Boer, Anne Duvekot, Bas in ‘t Veld, Alice Werger, Paul Dennesen, Charlotte Severijns, Jasper De Jong, Jens Hering, Rienk van Beek, Stefan Ivars, Ib Jammer, Alena Breidablik, Katharina Skirstad Hodt, Frode Fjellanger, Manuel Vico Avalos, Jannicke Mellin-Olsen, Elisabeth Andersson, Amir Shafi-Kabir, Ruby Molina, Stanley Wutai, Erick Morais, Glória Tareco, Daniel Ferreira, Joana Amaral, Maria de Lurdes, Goncalves Castro, Susana Cadilha, Sofia Appleton, Suzana Parente, Mariana Correia, Diogo Martins, Angela Monteirosa, Ana Ricardo, Sara Rodrigues, Lucian Horhota, Ioana Marina Grintescu, Liliana Mirea, Ioana Cristina Grintescu, Dan Corneci, Silvius Negoita, Madalina Dutu, Ioana Popescu Garotescu, Daniela Filipescu, Alexandru Bogdan Prodan, Gabriela Droc, Ruxandra Fota, Mihai Popescu, Dana Tomescu, Ana Maria Petcu, Marian Irinel Tudoroiu, Alida Moise, Catalin-Traian Guran, Iorel Gherghina, Dan Costea, Iulia Cindea, Sanda-Maria Copotoiu, Ruxandra Copotoiu, Victoria Barsan, Zsolt Tolcser, Magda Riciu, Septimiu Gheorghe Moldovan, Mihaly Veres, Alexey Gritsan, Tatyana Kapkan, Galina Gritsan, Oleg Korolkov, Alexander Kulikov, Andrey Lubnin, Alexey Ovezov, Pavel Prokoshev, Alexander Lugovoy, Natalia Anipchenko, Andrey Babayants, Irina Komissarova, Karginova Zalina, Valery Likhvantsev, Sergei Fedorov, Aleksandra Lazukic, Jasmina Pejakovic, Dunja Mihajlovic, Zuzana Kusnierikova, Maria Zelinkova, Katarina Bruncakova, Lenka Polakovicova, Villiam Sobona, Barbka Novak-Supe, Ana Pekle-Golez, Miroljub Jovanov, Branka Strazisar, Jasmina Markovic-Bozi, Vesna Novak-Jankovic, Minca Voje, Andriy Grynyuk, Ivan Kostadinov, Alenka Spindler-Vesel, Victoria Moral, Mari Carmen Unzueta, Carlos Puigbo, Josep Fava, Jaume Canet, Enrique Moret, Mónica Rodriguez Nunez, Mar Sendra, Andrea Brunelli, Frederic Rodenas, Pablo Monedero, Francisco Hidalgo Martinez, Maria Jose Yepes Temino, Antonio Martínez Simon, Ana de Abajo Larriba, Alberto Lisi, Gisela Perez, Raquel Martinez, Manuel Granell, Jose Tatay Vivo, Cristina Saiz Ruiz, Jose Antonio de Andrés Ibañez, Ernesto Pastor, Marina Soro, Carlos Ferrando, Mario Defez, Cesar Aldecoa Alvares-Santullano, Rocio Perez, Jesus Rico, Monir Jawad, Yousif Saeed, Lars Gillberg, Zuleyha Kazak Bengisun, Baturay Kansu Kazbek, Nesil Coskunfirat, Neval Boztug, Suat Sanli, Murat Yilmaz, Necmiye Hadimioglu, Nuzhet Mert Senturk, Emre Camci, Semra Kucukgoncu, Zerrin Sungur, Nukhet Sivrikoz, Serpil Ustalar Ozgen, Fevzi Toraman, Onur Selvi, Ozgur Senturk, Mine Yildiz, Bahar Kuvaki, Ferim Gunenc, Semih Kucukguclu, Şule Ozbilgin, Jale Maral, Seyda Canli, Oguzhan Arun, Ali Saltali, Eyup Aydogan, Fatma Nur Akgun, Ceren Sanlikarip, Fatma Mine Karaman, Andriy Mazur, Sergiy Vorotyntsev, Guy Rousseau, Colin Barrett, Lucia Stancombe, Ben Shelley, Helen Scholes, James Limb, Amir Rafi, Lisa Wayman, Jill Deane, David Rogerson, John Williams, Susan Yates, Elaine Rogers, Mark Pulletz, Sarah Moreton, Stephanie Jones, Suresh Venkatesh, Maudrian Burton, Lucy Brown, Cait Goodall, Matthew Rucklidge, Debbie Fuller, Maria Nadolski, Sandeep Kusre, Michael Lundberg, Lynn Everett, Maka Zuleika, Peter Carvalho, Deborah Clements, Ben Creagh-Brown, Philip Watt, Parizade Raymode, Rupert Pearse, Otto Mohr, Ashok Raj, Thais Creary, Ahmed Chishti, Andrea Bell, Charley Higham, Alistair Cain, Sarah Gibb, Stephen Mowat, Danielle Franklin, Claire West, Gary Minto, Nicholas Boyd, Gary Mills, Emily Calton, Rachel Walker, Felicity Mackenzie, Branwen Ellison, Helen Roberts, Moses Chikungwa, Clare Jackson, Andrew Donovan, Jayne Foot, Elizabeth Homan, Jane Montgomery, David Portch, Pauline Mercer, Janet Palmer, Jonathan Paddle, Anna Fouracres, Amanda Datson, Alyson Andrew, Leanne Welch, Alastair Rose, Sandeep Varma, Karen Simeson, Mrutyunjaya Rambhatla, Jaysimha Susarla, Sudhakar Marri, Krishnan Kodaganallur, Ashok Das, Shivarajan Algarsamy, Julie Colley, Simon Davies, Margaret Szewczyk, Thomas Smith, Ana Fernandez- Bustamante, Elizabeth Luzier, Angela Almagro, Marcos Vidal Melo, Luiz Fernando, Demet Sulemanji, Juraj Sprung, Toby Weingarten, Daryl Kor, Federica Scavonetto, Yeo Tze, Schultz, Marcus, J, Servillo, G, Vargas, M, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Anesthesiology research group, Supporting clinical sciences, Anesthesiology, Graduate School, AII - Amsterdam institute for Infection and Immunity, Intensive Care Medicine, AII - Inflammatory diseases, ACS - Heart failure & arrhythmias, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, APH - Global Health, ACS - Diabetes & metabolism, ACS - Microcirculation, Marcus, J (LAS VEGAS study investigator, the PROVE Network and the Clinical Trial Network of the European Society of, Anaesthesiology), Zangrillo, A, Beretta, L, and Landoni, G

Subjects
Adult, Male, medicine.medical_specialty, Intra operative, health care facilities, manpower, and services, [SDV]Life Sciences [q-bio], Critical Illness, Las Vegas Study, Article, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Internal medicine, Tidal Volume, medicine, Humans, General anaesthesia, Lung, Tidal volume, Female, Respiration, Artificial, Sex Characteristics, Las vegas, business.industry, Respiration, respiratory failure, sex, respiratory system, Sex difference, respiratory tract diseases, Anesthesiology and Pain Medicine, 030228 respiratory system, Relative risk, Artificial, Cohort, Breathing, Observational study, business, intra-operative tidal volume, circulatory and respiratory physiology
Abstract

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (V(T)). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients. OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference. DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries. MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as V(T) of 8 ml kg(−1) or less predicted bodyweight (PBW). A V(T) was deemed ‘default’ if the set V(T) was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation. RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default V(T) was often set, both in women and men; mode V(T) was 500 ml. Median [IQR] V(T) was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg(−1) PBW, P*** < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P*** < 0.001]. In the mediation analysis, patients’ height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default V(T). CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher V(T) than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV. TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223

Published
2021

23. Italian pool of asbestos workers cohorts: Mortality trends of asbestos-related neoplasms after long time since first exposure

Author

Simona Menegozzo, Dario Mirabelli, Francesco Cuccaro, Orietta Sala, Francesco Barone-Adesi, Daniela Ferrante, Vittoria Bressan, Lucia Miligi, Alessandro Marinaccio, Aldo Pettinari, Corrado Magnani, Paolo Girardi, Enzo Merler, Elisabetta Chellini, Venere Pavone, Alessandra Ranucci, Enrico Oddone, Patrizia Legittimo, Stefano Mattioli, Corrado Scarnato, Stefano Silvestri, Sara Tunesi, Laura Ancona, Patrizia Perticaroli, Roberta Pirastu, Marina Musti, Antonio Baldassarre, Tiziana Cena, Giuseppe Gorini, Elisa Romeo, Ferdinando Luberto, Ferrante, Daniela, Chellini, Elisabetta, Merler, Enzo, Pavone, Venere, Silvestri, Stefano, Miligi, Lucia, Gorini, Giuseppe, Bressan, Vittoria, Girardi, Paolo, Ancona, Laura, Romeo, Elisa, Luberto, Ferdinando, Sala, Orietta, Scarnato, Corrado, Menegozzo, Simona, Oddone, Enrico, Tunesi, Sara, Perticaroli, Patrizia, Pettinari, Aldo, Cuccaro, Francesco, Mattioli, Stefano, Baldassarre, Antonio, Barone-Adesi, Francesco, Cena, Tiziana, Legittimo, Patrizia, Marinaccio, Alessandro, Mirabelli, Dario, Musti, Marina, Pirastu, Roberta, Ranucci, Alessandra, Magnani, Corrado, [.., Curti, Stefania, and ]

Subjects
Male, Mesothelioma, Occupational cancer, Lung Neoplasms, Asbestosis, medicine.disease_cause, Cohort Studies, Economica, 0302 clinical medicine, Cause of Death, PLEURAL MESOTHELIOMA, TEXTILE WORKERS, Pleural Neoplasm, Lung, Peritoneal Neoplasms, Cause of death, LARYNGEAL-CANCER-MORTALITY, RISK, Ovarian Neoplasms, Asbestosi, Middle Aged, peritoneum, 030210 environmental & occupational health, Asbestos cement, Occupational Diseases, pleura, Italy, 030220 oncology & carcinogenesis, malignant mesothelioma, Female, Public Health, Peritoneal Neoplasm, FIBERS, Carcinogen, Cohort study, Human, Adult, medicine.medical_specialty, Pleural Neoplasms, MODELS, Socio-culturale, Asbesto, Asbestos, Settore MED/01 - Statistica Medica, CEMENT WORKERS, 03 medical and health sciences, LUNG-CANCER, asbestos, occupational cancer, ovary, Internal medicine, Occupational Exposure, medicine, Humans, METAANALYSIS, Aged, LARYNGEAL-CANCER-MORTALITY, PLEURAL MESOTHELIOMA, TEXTILE WORKERS, LUNG-CANCER, FOLLOW-UP, CEMENT WORKERS,MODELS, RISK, METAANALYSIS, FIBERS, business.industry, Construction Materials, Ovarian Neoplasm, Environmental and Occupational Health, Mesothelioma, Malignant, Ovary, Public Health, Environmental and Occupational Health, Ambientale, medicine.disease, Surgery, Construction Material, Lung Neoplasm, Occupational Disease, Carcinogens, Cohort Studie, FOLLOW-UP, Ovarian cancer, business
Abstract

Objective Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. Methods Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010. SMRs were computed for the 1970–2010 period, for the major causes, with consideration of duration and TSFE, using reference rates by age, sex, region and calendar period. Results The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Mortality was significantly increased for all deaths (SMR: men: 1.05, 95% CI 1.03 to 1.06; women: 1.17, 95% CI to 1.12 to 1.22), all malignancies combined (SMR: men: 1.17, 95% CI to 1.14 to 1.20; women: 1.33, 95% CI 1.24 to 1.43), pleural and peritoneal malignancies (SMR: men: 13.28 and 4.77, 95% CI 12.24 to 14.37 and 4.00 to 5.64; women: 28.44 and 6.75, 95% CI 23.83 to 33.69 and 4.70 to 9.39), lung (SMR: men: 1.26, 95% CI 1.21 to 1.31; women: 1.43, 95% CI 1.13 to 1.78) and ovarian cancer (SMR=1.38, 95% CI 1.00 to 1.87) and asbestosis (SMR: men: 300.7, 95% CI 270.7 to 333.2; women: 389.6, 95% CI 290.1 to 512.3). Pleural cancer rate increased during the first 40 years of TSFE and reached a plateau after. Discussion The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. Pleural cancer mortality reached a plateau at long TSFE, coherently with recent reports.

Published
2017

24. A Retrospective Cohort Study of Young Women Spontaneously Choosing to Be Vaccinated against HPV: Outcomes from Their First Cervical Cancer Screening Test.

Author

Del Mistro A, Battagello J, Weis L, Bressan V, Selle V, Ramigni M, Dal Zotto A, Maggiolo A, Gori S, Frayle H, Zappa M, Zorzi M, and The Consensus Study Veneto Working Group

Subjects
Adolescent, Adult, Early Detection of Cancer, Female, Humans, Italy epidemiology, Mass Screening, Retrospective Studies, Young Adult, Papillomavirus Infections prevention & control, Papillomavirus Vaccines administration & dosage, Uterine Cervical Neoplasms prevention & control
Abstract

Background: Efficacy for cervical cancer prevention of opportunistic HPV vaccination in post-pubertal girls is lower than in 11-year-olds., Methods: Women born between 1986 and 1992 vaccinated at 15-25 years of age (at least one dose of 4-valent HPV vaccine) and screened at 24-27 years of age were included. Frequency of opportunistic vaccination, overall and by birth cohort, was calculated; screening outcomes were compared between vaccinated and unvaccinated women., Results: Overall, 4718 (4.9%) HPV-vaccinated, and 91,512 unvaccinated, women were studied. The frequency of vaccination increased by birth cohort, ranging between 1.8% and 9.8%; age at vaccination decreased progressively by birth cohort ( p < 0.0001). Participation in screening was 60.8% among vaccinated, and 56.6% among unvaccinated, women ( p < 0.0001). Detection rates (DR) for high-grade lesions were lower in vaccinated women (2.11‰ vs. 3.85‰ in unvaccinated, for CIN3+, p = 0.24; 0.0‰ vs. 0.22‰ for cancer). The DR of CIN3+ increased with age at vaccination, scoring respectively 0.0‰, 0.83‰, and 4.68‰ for women vaccinated when they were 15-16, 17-20, and 21-25 years old ( p = 0.17)., Conclusions: In comparison to unvaccinated women, higher compliance with cervical cancer screening invitation and lower CIN3+ DR among vaccinated women was observed. Age at vaccination was inversely correlated to vaccination efficacy.

Published
2021
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25. [Time trend in mesothelioma and lung cancer risk in asbestos workers in Italy].

Author

Magnani C, Ancona L, Baldassarre A, Bressan V, Cena T, Chellini E, Cuccaro F, Ferrante D, Legittimo P, Luberto F, Marinaccio A, Mattioli S, Menegozzo S, Merler E, Miligi L, Mirabelli D, Musti M, Oddone E, Pavone V, Perticaroli P, Pettinari A, Pirastu R, Ranucci A, Romeo E, Sala O, Scarnato C, and Silvestri S

Subjects
Asbestos, Asbestosis, Female, Humans, Italy epidemiology, Male, Occupational Diseases, Lung Neoplasms epidemiology, Mesothelioma epidemiology, Occupational Exposure
Abstract

This study aims at investigating, in asbestos exposed workers, the time trend of their risk of mesothelioma and of other neoplasm after very long latency and after the cessation of asbestos exposure. We pooled a large number of Italian cohorts of asbestos workers and updated mortality follow-up. The pool of data for statistical analyses includes 51,988 workers, of which 6,058 women: 54.2% was alive at follow-up, 42.6% was dead, and 2.8%was lost. Cause of death is known for 94.3%: 2,548 deaths from lung cancer, 748 frompleural cancer, 173 fromperitoneal cancer, and 434 from asbestosis. An exposure index is being developed to compare the different cohorts. Data analysis is in progress. This study will have the size for analysing not only time trends in mesothelioma, but also the occurrence of rarer diseases and cancer specific mortality in women.

Published
2016
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26. [Confirmation of an excess of cancer mortality in a cohort of workers of a chromium thin-layer plating].

Author

Girardi P, Bressan V, Mabilia T, and Merler E

Subjects
Cohort Studies, Follow-Up Studies, Humans, Italy epidemiology, Lung Neoplasms chemically induced, Metallurgy, Nose Neoplasms chemically induced, Occupational Diseases chemically induced, Pancreatic Neoplasms chemically induced, Pancreatic Neoplasms mortality, Retrospective Studies, Risk Factors, Time Factors, Carcinogens, Chromium adverse effects, Electroplating, Lung Neoplasms mortality, Nose Neoplasms mortality, Occupational Diseases mortality, Occupational Exposure adverse effects, Tin adverse effects
Abstract

Objectives: to extend up to year 2013 the follow-up for mortality of a cohort of workers in a chromium and nickel plating plant, where an excess of lung cancers was already identified., Design: 10 years after the first study about cancer mortality in a cohort of workers involved in the chromium thin-layer plating, published in 2006, we updated the evaluation of themortality of a cohort ofworkers employed in the same chromiumthin-layer plating factory with at least 6 months of work between 1968 and 1994.The mortality rates are compared with those of the Italian and Veneto Region (Northern Italy) populations.The dose-response relationship between work duration and lung cancer is assessed by adjusted Poisson regression., Setting and Participants: 127 unskilled or skilled workers involved in the production process., Results: in the updated follow-up, 35 deaths occurred among the subjects under study: 19 for cancer (of which 11 for lung cancer and 3 for pancreatic cancer). A marked excess ofmortality due to lung cancer is observed. In addition, the newfollowup shows a significant excess of pancreatic cancer mortality. Lung cancer mortality is positively associated with work duration and the risk increases by 13%(95%CI 1-26) for each additional year of work., Conclusions: the extension of followup confirms that this cohort expresses an increased mortality from cancer deaths, due to a marked excess of lung and pancreatic cancers. The effect of smoking has only a secondary effect in the cancer onset expressed by this cohort. The risk of lung cancer increased with work duration and thus with occupational exposure to chromium and nickel.

Published
2015

27. [The effectiveness of compensation system for mesotheliomas due to occupational exposure to asbestos and determinants for requests and awards: an evaluation based on record-linkage between the Veneto Mesothelioma Register and the claims and compensations recorded by the National Insurance Institute (INAIL)].

Author

Merler E, Bressan V, Bilato AM, and Marinaccio A

Subjects
Academies and Institutes statistics & numerical data, Aged, Female, Humans, Insurance Claim Reporting statistics & numerical data, Italy epidemiology, Male, Mesothelioma epidemiology, Mesothelioma etiology, Middle Aged, Occupations, Pleural Neoplasms epidemiology, Pleural Neoplasms etiology, Prejudice, Program Evaluation, Registries statistics & numerical data, Socioeconomic Factors, Workers' Compensation economics, Workers' Compensation standards, Asbestos adverse effects, Insurance Benefits statistics & numerical data, Insurance Claim Review, Medical Record Linkage, Mesothelioma economics, Occupational Exposure, Pleural Neoplasms economics, Workers' Compensation statistics & numerical data
Abstract

Aim: To determine the rate of requests for compensation and of compensations awarded for mesothelioma cases due to occupational exposure to asbestos; to identify factors that may influence the outcome; to provide an appreciation of the amount of compensation., Design and Main Outcome Measures: Record-linkage study at individual level between the new cases of mesothelioma occurred among the residents of the Veneto Region (Northern Italy) between 1999- 2007 and the file of the Insurance Institute, with individual data on all claims and compensations. Adjusted logistic regression models were used to estimated the association between submitting claims and obtaining an award and socio-demographic and other characteristics., Results: 349 on 499 mesotheliomas considered to be due to occupational exposure to asbestos submitted a claim (70% of those of occupational origin) and 72%of claims were accepted. The welfare system covers only 35%of mesothelioma occurred. The probability of submitting and obtaining a claim was associated with gender, cancer site, age at diagnosis, vital status, and residence or local office in charge of the evaluation. A strong discrimination against women is observed. If exposure to asbestos at work was due to a direct manipulation of asbestos, claims were more easily accepted.As a consequence,mesothelioma occurred among construction workers, the occupational activity at the origin of the largest number of occurring mesotheliomas, are more frequently rejected.When submitted by a relative, the lag between a request for compensation and the decision is on average of about two years., Conclusion: This is the first study in Italy using a record-linkage method and was made possible thanks to a population based mesothelioma Register and the availability of memorized information of the Insurance Institute.The welfare system shown clear limitations and there is the need for more appropriate strategies.

Published
2011

28. [Mesothelioma in construction workers: risk estimate, lung content of asbestos fibres, claims for compensation for occupational disease in the Veneto Region mesothelioma register].

Author

Merler E, Bressan V, and Somigliana A

Subjects
Aged, Female, Humans, Italy, Male, Risk Assessment, Asbestos analysis, Lung chemistry, Mesothelioma epidemiology, Mineral Fibers analysis, Occupational Diseases epidemiology, Registries, Workers' Compensation statistics & numerical data
Abstract

Background: Work in the construction industry is causing the highest number of mesotheliomas among the residents of the Veneto Region (north-east Italy, 4,5 million inhabitants)., Objectives: To sum up the results on occurrence, asbestos exposure, lung fibre content analyses, and compensation for occupational disease., Methods: Case identification and asbestos exposure classification: active search of mesotheliomas that were diagnosed via histological or cytological examinations occurring between 1987 and 2006; a probability of asbestos exposure was attributed to each case, following interviews with the subjects or their relatives and collection of data on the jobs held over their lifetime. Risk estimate among construction workers: the ratio between cases and person-years, the latter derived from the number of construction workers reported by censuses. Lung content of asbestos fibres: examination of lung specimens by Scanning Electron Microscope to determine number and type of fibres. Claims for compensation and compensation awarded: data obtained from the National Institute for Insurance against Occupational Diseases available for the period 1999-2006., Results: of 952 mesothelioma cases classified as due to asbestos exposure, 251 were assigned to work in the construction industry (21 of which due to domestic of environmental exposures), which gives a rate of 4.1 (95% CI 3.6-4.8) x 10(5) x year among construction workers. The asbestos fibre content detected in the lungs of 11 construction workers showed a mean of 1.7 x 10(6) fibres/g dry tissue (range 350,000-3 million) for fibres > 1 micro, almost exclusively due to amphibole fibres. 62% of the claims for compensation were granted but the percentage fell to less than 40% when claims were submitted by a relative, after the death of the subject., Conclusion: The prevalence of mesothelioma occurring among construction workers is high and is associated with asbestos exposure; the risk is underestimated by the subjects and their relatives. All mesotheliomas occurring among construction workers should be granted compensation for occupational disease.

Published
2009

29. [Malignant mesothelioma in the Veneto Region (north-east of Italy), 1988-2002: incidence, geographical analysis, trends and comparison with mortality].

Author

Roberti S, Merler E, Bressan V, and Fiore AR

Subjects
Cluster Analysis, Confidence Intervals, Female, Humans, Incidence, Italy epidemiology, Male, Mesothelioma etiology, Mesothelioma mortality, Pleural Neoplasms etiology, Pleural Neoplasms mortality, Risk Factors, Sex Factors, Asbestos adverse effects, Mesothelioma epidemiology, Pleural Neoplasms epidemiology
Abstract

Objective: The study assesses incidence and trend of malignant mesothelioma (MM), and mortality from primary pleural tumour (PPT) among residents of the Veneto region (North-east of Italy 4,450,000 inhabitants at the last census). The study also aims at identifying areas at high risk, by applying geographical analysis techniques., Method: The results have been obtained through the activity ofa Mesothelioma Registry, established in 2001, thus collecting largely retrospective data. Incidence and trends are estimated on MM diagnosed between 1988 and 2002 by means of histological or cytological techniques. Deaths from PPT are derived through the availability of mortality records for the period 1988-1999 (latest year available). Direct age-standardization was applied to provincial rates (7 provinces), whereas standardized mortality and incidence ratios according to Kernel estimates and spatial scan statistics have been used to identify clusters at the municipality level (581 municipalities)., Results and Conclusions: the incidence of MM in the Veneto region appears similar to that of other northern Italian regions (904 new MM cases from 1988 to 2002, 650 among males, 819 pleural; age-standardized annual incidence rates x 100,000 in the period 1988-1999): 1.75 (IC 95% 1.59-1.91) among males, based on 460 cases, and 0.67 (IC 95% 0.57-0.77) among females, based on 196 cases, and displays an increasing trend among both genders. Among males incidence doubles during the study period. High risks are detected among males in a cluster formed by the city of Venice and surrounding municipalities (Standardized Incidence Ratio, SIR, for pleural mesothelioma, 1988-1999, 2.94 (p = 0.001) for the cluster based on 110 observed cases), and, in addition to Venice, in the province of Padua among females (SIR from pleural mesothelioma, 1988-1999, 1.98 (p = 0.001) for the cluster based on 95 observed cases). Mortality from TPP turns out to be higher than incidence and tends to approach incidence in more recent years; this may be explained by the increasing application of diagnostic procedures, inclusive of histopathological tests, among old patients.

Published
2007

30. [Systematic research and etiological diagnosis of lung tumors].

Author

Merler E, Roberti S, and Bressan V

Subjects
Italy, Lung Neoplasms etiology, Mesothelioma etiology, Occupations, Asbestos adverse effects, Lung Neoplasms diagnosis, Mesothelioma diagnosis, Occupational Exposure adverse effects
Published
2006

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