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Researchers from IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli in Brescia, Italy, conducted a study on the quality of life of women with diagnoses of both endometriosis and infertility after failed Assisted Reproductive Treatments (ART). The study included both quantitative and qualitative surveys, revealing that women who have experienced previous spontaneous miscarriages are at higher risk for low quality of life. The research highlighted the physical, relational, social, emotional-cognitive, and behavioral impact of these diseases on women, emphasizing the need for multi-level preventive or supportive programs for this population. [Extracted from the article]

Researchers at the University of Brescia conducted a study on the usefulness of last-generation insertable cardiac monitors (LG-ICM) in diagnosing unexplained syncope (US). The study found that LG-ICM had a diagnostic yield of 42%, detecting cardiac arrhythmias in 27% of patients and guiding the implantation of cardiac electronic devices in 15% of patients. Age and atrial arrhythmia history were identified as independent predictors of significant arrhythmias detected by LG-ICM. The research was published in the International Journal of Cardiology and has been peer-reviewed. [Extracted from the article]

A study conducted in Brescia, Italy, examined the long-term organ damage accrual and late mortality in patients with systemic sclerosis (SSc). The researchers used the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI) to measure organ damage accrual. They found that the SCTC-DI score progressively increased over a 10-year period, with 34% of patients showing moderate or severe damage. Factors associated with damage accrual and late mortality were identified, including the type of SSc and the presence of certain antibodies. The study concluded that higher SCTC-DI scores and annual rise were associated with late mortality in SSc patients. [Extracted from the article]

A recent study conducted by the University of Brescia in Italy examined the natural history of cerebral visual impairment (CVI) in children with cerebral palsy (CP). The researchers evaluated the visual function of 51 individuals with CP and CVI at three different time points. They found that while ophthalmological deficits remained stable over time, other visual signs and symptoms, such as fixation, smooth pursuit, and visual acuity, improved. The study highlights the "permanent" but "not unchanging" nature of CVI associated with CP during development. [Extracted from the article]

New research from Brescia, Italy explores the association between copper biomarkers and clinical classification in mental health disorders. The study compared copper biomarkers in 171 patients with psychiatric disorders and 61 healthy controls, finding that copper levels were higher in psychiatric individuals, particularly those with mood spectrum disorders. The analysis also revealed that women with mood spectrum disorders had increased copper levels compared to healthy women. The research suggests mild copper toxicity in women with mood spectrum disorders and highlights the potential for further investigation into the diagnostic accuracy of copper biomarkers in larger cohorts. [Extracted from the article]

Researchers at the Institute for Cancer Research and Treatment in Brescia, Italy, have conducted a study to investigate the cognitive and neuropsychological effects of a 5-week treatment using ozone therapy on cognitive frailty (CF). CF is a syndrome that is becoming a significant health problem as the global population ages. The study involved 75 older individuals who were randomly assigned to receive either the active treatment, oxygen, or a placebo for 5 weeks. The researchers aimed to assess the change in clinical scales and biomarker levels resulting from the treatment. The study's positive results could have important clinical implications. [Extracted from the article]

A report from Children's Hospital in Brescia, Italy discusses the use of ultrasound-guided implantation of central venous catheters in pediatric patients. The study found that after implementing structured training for this technique, the use of surgical venolysis, a more invasive method, was eliminated. The training also resulted in a decrease in procedure duration and improved safety. The researchers recommend standardized training for ultrasound-guided implantation in the future. [Extracted from the article]

A recent study conducted in Brescia, Italy, examined the impact of caregiver burden on the mental and physical health of patients undergoing coronary artery bypass graft (CABG) surgery. The study found that an increase in caregiver burden from pre- to two-months post-surgery was associated with higher levels of depressive and anxiety symptoms in patients, as well as reduced physical health-related quality of life. However, these effects were not observed at the one-year follow-up. The findings suggest the importance of providing psychological support interventions for caregivers to improve patients' short-term recovery outcomes. [Extracted from the article]

A recent study conducted in Brescia, Italy, explored the impact of maternal autoimmune rheumatic diseases on the outcomes of children. The research found that these conditions can hinder fetal development, leading to growth restriction, preterm birth, and low birth weight. Treatment with immunomodulatory drugs aims to minimize the risk of adverse pregnancy outcomes, but concerns have been raised about the potential effects on neonatal conditions and long-term outcomes. The study provides a comprehensive overview of the literature and guidance on discussing these topics with patients. [Extracted from the article]

A new report from the University of Brescia in Italy provides fresh data on paragangliomas, a type of cancer that frequently leads to skeletal complications. The study aimed to describe the frequency of adverse skeletal related events (SREs) in patients with bone-metastatic paragangliomas. The research found that SREs occurred in 31% of patients, with bone fractures, spinal cord compression, and hypercalcemia being the most common events. Factors associated with a reduced risk of SREs and improved survival included I-131-MIBG radionuclide therapy, absence of liver metastases, and treatment with bone resorption inhibitors. The study concluded that these therapies are associated with favorable outcomes. [Extracted from the article]

A recent study conducted by researchers at the University of Brescia in Italy explores the relationship between functional mitral regurgitation (MR) and heart failure with preserved ejection fraction (HFpEF). The study highlights the common pathophysiology of MR and HFpEF, focusing on the development of elevated left ventricle filling pressure, diastolic dysfunction, and atrial dilatation and impairment. The researchers aim to provide an overview of the association and interplay between functional MR and HFpEF, as well as potential targeted pharmacological treatments. This research has been peer-reviewed and published in the Journal of Cardiac Failure. [Extracted from the article]

A recent study compared the outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. The study found that RLS was associated with higher rates of textbook outcome in liver surgery (TOLS) and TOLS+ compared to LLS. RLS also had advantages such as less blood loss, fewer conversions, and shorter operative times. However, the differences between RLS and LLS did not reach statistical significance for minor resections in the posterosuperior segments and major resections. Overall, both RLS and LLS produced excellent outcomes. [Extracted from the article]

A study conducted by the Department of Surgery in Brescia, Italy, compared the benefits of laparoscopic liver surgery to open liver surgery for lesions in the anterolateral (AL) and posterosuperior (PS) segments. The study found that laparoscopic liver resections were more advantageous than open surgeries in terms of blood loss, transfusion rate, complications, and length of stay. However, laparoscopy was found to be more beneficial for AL resections compared to PS resections in terms of overall and severe complications and blood loss. The study concluded that laparoscopic surgery is more advantageous in the AL segments than in the PS segments. [Extracted from the article]

A recent study conducted in Brescia, Italy, examined the diagnostic role of internal mammary lymph node (IMLN) involvement in tuberculous pleurisy (TP). The study compared the prevalence and test performance of IMLN involvement in patients with TP, non-tuberculous pleurisy (NTIP), and controls without respiratory diseases. The results showed that the prevalence of IMLN involvement was significantly higher in TP patients compared to NTIP and control groups. The study concluded that evaluating IMLN involvement is important in assessing the pre-test probability of TP, especially in areas with limited diagnostic resources. [Extracted from the article]

A recent study conducted at the University of Brescia in Italy explored the use of tyrosine kinase inhibitors (TKIs) as a treatment option for elderly patients with chronic myeloid leukemia (CML). The study compared two different schedules of TKI therapy: a fixed schedule and a progressive intermittent schedule. The findings showed that both schedules were safe and feasible, with the progressive intermittent schedule associated with a higher incidence of molecular remission loss. Health-related quality of life improved during both schedules, and the progressive schedule was considered a valid tool for selecting patients eligible for TKI discontinuation. Overall, the study found that the quality of life generally improved during the de-escalation therapy in both arms of the study. [Extracted from the article]

A recent study conducted by the Department of Surgery in Brescia, Italy, examined the impact of neoadjuvant chemotherapy on the outcomes of minimally invasive liver resections for colorectal liver metastases. The study analyzed a database of 4,998 patients and found that neoadjuvant chemotherapy did not have a statistically significant effect on the short-term surgical outcomes of these procedures. The research suggests that neoadjuvant chemotherapy can be safely used in conjunction with minimally invasive liver resections for colorectal liver metastases. This study was funded by various organizations, including the US National Cancer Institute and the Intuitive Foundation. [Extracted from the article]

A recent study conducted by researchers from the University of Brescia in Italy explores the diagnosis, prevention, and treatment of critical illness weakness (CIW) and critical illness associated diaphragmatic weakness (CIDW). The study highlights the different risk factors and pathophysiological mechanisms associated with CIW and CIDW, as well as the impact on patient outcomes. The researchers emphasize the challenges in diagnosing these conditions and the need for improved monitoring techniques and therapeutic interventions. The study also discusses promising diagnostic techniques that could be implemented in clinical practice. [Extracted from the article]

A new report from the University of Brescia in Italy highlights the benefits of cognitive remediation for individuals with schizophrenia. The study found that cognitive remediation led to significant improvements in cognitive performance and real-world functioning for people with schizophrenia. These benefits were found to persist over time, suggesting that cognitive remediation should be more widely implemented in clinical and rehabilitation practice. The study also identified certain factors that were associated with better outcomes, such as longer treatment duration, techniques for transferring cognitive gains to the real world, and integration with psychiatric rehabilitation. [Extracted from the article]

A recent study conducted by researchers at ASST Spedali Civili in Brescia, Italy, has found that a pseudo-tunneling procedure can be used to insert peripherally inserted central catheters with ports (PICC-Ports) in patients with small veins at the middle third of the arm. The study involved 42 patients, and all procedures were successfully performed without any complications. The researchers concluded that pseudo-tunneling is a safe and effective technique for PICC-Ports insertion in patients with small veins. This research has been peer-reviewed and provides valuable insights for healthcare professionals working in the field of surgery. [Extracted from the article]

A recent report from the University of Brescia in Italy provides a critical review of evidence-based psychosocial interventions for schizophrenia. The study highlights the importance of these interventions in improving cognitive performance, social skills, and overall functioning for individuals with schizophrenia. The review identifies several interventions, such as cognitive remediation, metacognitive training, social skills training, and family interventions, as effective treatments for schizophrenia. The researchers suggest that future research should focus on developing new interventions, understanding implementation barriers, and exploring the potential of novel technologies in this field. [Extracted from the article]

A report from the University of Brescia in Italy discusses the potential of radiomics, a noninvasive method that uses medical imaging to extract quantitative data from tumors, in predicting patient responsiveness to laryngeal preservation strategies for laryngeal cancer. The report highlights the promising results of studies that have used radiomics to assess the tumor and predict response to induction chemotherapy and radiation therapy. However, the report also emphasizes the need for larger multicentric studies to validate the value of radiomics in this field. The research concludes that while there are some early promising studies, the lack of validation and larger studies limits the application of radiomics in clinical practice. [Extracted from the article]

A new report from the University of Brescia in Italy provides data on Early Onset Absence Epilepsy (EOAE) in children. The researchers conducted a retrospective study of 56 patients with absence epilepsy who had onset before the age of four. They found that patients with earlier onset had a worse outcome and lower drug sensitivity. The study suggests that this information could help predict cases where prolonged antiseizure therapy is necessary. [Extracted from the article]

A recent study conducted by researchers at Universita degli Studi di Brescia in Italy explored the association between metal exposure and olfactory function in children and adolescents. The study found that exposure to a mixture of 12 metals, including lead, cadmium, and arsenic, measured in indoor dust, was significantly associated with reduced olfactory function. The researchers suggest that preventing olfactory dysfunctions can improve quality of life and prevent neurodegenerative diseases. The identification of factors that can deteriorate olfactory functions can be helpful in preventing long-term health implications. [Extracted from the article]

A recent study conducted by the University of Brescia in Italy used machine learning techniques to identify predictors of suicide risk among college students. The study surveyed 3,102 students and found that 7% showed high potential suicide risk, while 3.8% had a history of suicide attempts. Psychological distress and the use of alcohol and substances were identified as prominent predictors of suicide risk. The researchers suggest that machine learning techniques could be used to develop more effective prevention programs tailored to the needs of different student risk profiles. [Extracted from the article]

A recent study conducted by researchers at the University of Brescia in Italy explores the impact of transcranial magnetic stimulation (TMS) on cortical excitability and plasticity across the lifespan. The study investigates the role of TMS in understanding normal development, healthy aging, neurodevelopmental disorders, and adult-onset neurodegenerative diseases. The researchers highlight the potential of TMS as a valuable tool for unraveling underlying mechanisms and informing therapeutic interventions. The study concludes that TMS studies have advanced our understanding of neuropsychiatric conditions and have the potential to inform the development of targeted diagnostic and therapeutic strategies. [Extracted from the article]

A report from the University of Brescia in Italy discusses research findings on drug research. The researchers highlight the need to assess evidence in favor of a practically relevant effect, rather than simply determining its presence or absence. They propose a method for modifying standard tests to deal with appropriate interval null hypotheses that contain all practically irrelevant effect sizes. The researchers apply their proposed methods to two case studies in clinical medicine, one involving systolic blood pressure in adults at risk for nutritional deficit and another involving the effects of remdesivir on COVID-19 patients. The research has been peer-reviewed and more information can be obtained from the University of Brescia. [Extracted from the article]

A recent report from the University of Brescia in Italy discusses new findings in the treatment of diabetes mellitus. The research highlights the limitations of solely focusing on improving glycemic control and emphasizes the importance of considering other mechanisms beyond hypoglycemic effects. The study points to the positive outcomes observed with GLP-1RAs and SGLT2i in cardiovascular trials, indicating a paradigm shift in diabetes treatment. While there is still much to learn, this research marks the beginning of a new era in diabetes management. [Extracted from the article]