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892 results on '"Brenner, Sydney"'

2. Author Correction: Elephant shark genome provides unique insights into gnathostome evolution.

Author

Venkatesh, Byrappa, Lee, Alison, Ravi, Vydianathan, Maurya, Ashish, Lian, Michelle, Swann, Jeremy, Ohta, Yuko, Flajnik, Martin, Sutoh, Yoichi, Kasahara, Masanori, Hoon, Shawn, Gangu, Vamshidhar, Roy, Scott, Irimia, Manuel, Korzh, Vladimir, Kondrychyn, Igor, Lim, Zhi, Tay, Boon-Hui, Tohari, Sumanty, Kong, Kiat, Ho, Shufen, Lorente-Galdos, Belen, Quilez, Javier, Marques-Bonet, Tomas, Raney, Brian, Ingham, Philip, Tay, Alice, Hillier, LaDeana, Minx, Patrick, Boehm, Thomas, Wilson, Richard, Brenner, Sydney, and Warren, Wesley

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

3. Levering Up to Do Good: Direct Long–Short Investing and Charitable Giving.

Author

Krasner, Stanley, Liberman, Joseph, Sosner, Nathan, and Brenner, Sydney

Subjects
STOCKS (Finance), COST, TAXATION
Abstract

The authors use historical strategy simulations to evaluate the advantages of donating appreciated stock in the context of tax-aware long–short factor strategies. Their main findings are as follows. First, long–short strategies have a higher donation capacity than long–only investments, and their donation capacity increases with leverage. Second, long–short strategies have a higher donation efficiency than long–only investments. Similar to donation capacity, donation efficiency increases with leverage. Third, long–short strategies receive a larger loss-realization boost from the donation of appreciated stocks than long–only investments, which also increases with leverage. Fourth, by removing appreciated positions from the strategy portfolio, higher donation targets reduce the tax costs of modifying the long–short strategy—for example, transitioning it to a long–only portfolio. Finally, when stock donations are done without replenishment, long–short portfolios offer pretax and after-tax performance that is far superior to that of long–only investment. Here, too, pretax and after-tax values achieved with long–short investments increase with leverage. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

Author

Aparicio, Samuel, Chapman, Jarrod, Stupka, Elia, Putnam, Nik, Chia, Jer-ming, Dehal, Paramvir, Christoffels, Alan, Rash, Sam, Hoon, Shawn, Smit, Arian, Roach, Jared, Oh, Tania, Ho, Isaac Y., Wong, Marie, Detter, Chris, Verhoef, Frans, Predki, Paul, Tay, Alice, Lucas, Susan, Richardson, Paul, Smith, Sarah F., Clark, Melody S., Doggett, Norman, Zharkikh, Andrey, Tavtigian, Sean V., Pruss, Dmitry, Barnstead, Mary, Evans, Cheryl, Baden, Holly, Powell, Justin, Glusman, Gustavo, Rowen, Lee, Hood, Leroy, Tan, Y. H., Elgar, Greg, Hawkins, Trevor, Venkatesh, Byrappa, Rokhsar, Daniel, and Brenner, Sydney

Published
2002

19. The hagfish genome and the evolution of vertebrates

Author

Marletaz, Ferdinand, primary, Timoshevskaya, Nataliya, additional, Timoshevskiy, Vladimir, additional, Simakov, Oleg, additional, Parey, Elise, additional, Gavriouchkina, Daria, additional, Suzuki, Masakazu, additional, Kubokawa, Kaoru, additional, Brenner, Sydney, additional, Smith, Jeramiah, additional, and Rokhsar, Daniel S., additional

Published
2023
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20. Supplementary Literature from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

Author

Ruhe, Jens E., primary, Streit, Sylvia, primary, Hart, Stefan, primary, Wong, Chee-Hong, primary, Specht, Katja, primary, Knyazev, Pjotr, primary, Knyazeva, Tatjana, primary, Tay, Liang Seah, primary, Loo, Hooi Linn, primary, Foo, Priscilla, primary, Wong, Winnie, primary, Pok, Sharon, primary, Lim, Shu Jing, primary, Ong, Huimin, primary, Luo, Ming, primary, Ho, Han Kiat, primary, Peng, Kaitian, primary, Lee, Tze Chuen, primary, Bezler, Martin, primary, Mann, Christian, primary, Gaertner, Silvia, primary, Hoefler, Heinz, primary, Iacobelli, Stefano, primary, Peter, Stephan, primary, Tay, Alice, primary, Brenner, Sydney, primary, Venkatesh, Byrappa, primary, and Ullrich, Axel, primary

Published
2023
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21. Supplementary Text from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

Author

Ruhe, Jens E., primary, Streit, Sylvia, primary, Hart, Stefan, primary, Wong, Chee-Hong, primary, Specht, Katja, primary, Knyazev, Pjotr, primary, Knyazeva, Tatjana, primary, Tay, Liang Seah, primary, Loo, Hooi Linn, primary, Foo, Priscilla, primary, Wong, Winnie, primary, Pok, Sharon, primary, Lim, Shu Jing, primary, Ong, Huimin, primary, Luo, Ming, primary, Ho, Han Kiat, primary, Peng, Kaitian, primary, Lee, Tze Chuen, primary, Bezler, Martin, primary, Mann, Christian, primary, Gaertner, Silvia, primary, Hoefler, Heinz, primary, Iacobelli, Stefano, primary, Peter, Stephan, primary, Tay, Alice, primary, Brenner, Sydney, primary, Venkatesh, Byrappa, primary, and Ullrich, Axel, primary

Published
2023
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22. Supplementary Tables 1-14 from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

Author

Ruhe, Jens E., primary, Streit, Sylvia, primary, Hart, Stefan, primary, Wong, Chee-Hong, primary, Specht, Katja, primary, Knyazev, Pjotr, primary, Knyazeva, Tatjana, primary, Tay, Liang Seah, primary, Loo, Hooi Linn, primary, Foo, Priscilla, primary, Wong, Winnie, primary, Pok, Sharon, primary, Lim, Shu Jing, primary, Ong, Huimin, primary, Luo, Ming, primary, Ho, Han Kiat, primary, Peng, Kaitian, primary, Lee, Tze Chuen, primary, Bezler, Martin, primary, Mann, Christian, primary, Gaertner, Silvia, primary, Hoefler, Heinz, primary, Iacobelli, Stefano, primary, Peter, Stephan, primary, Tay, Alice, primary, Brenner, Sydney, primary, Venkatesh, Byrappa, primary, and Ullrich, Axel, primary

Published
2023
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23. Data from Genetic Alterations in the Tyrosine Kinase Transcriptome of Human Cancer Cell Lines

Author

Ruhe, Jens E., primary, Streit, Sylvia, primary, Hart, Stefan, primary, Wong, Chee-Hong, primary, Specht, Katja, primary, Knyazev, Pjotr, primary, Knyazeva, Tatjana, primary, Tay, Liang Seah, primary, Loo, Hooi Linn, primary, Foo, Priscilla, primary, Wong, Winnie, primary, Pok, Sharon, primary, Lim, Shu Jing, primary, Ong, Huimin, primary, Luo, Ming, primary, Ho, Han Kiat, primary, Peng, Kaitian, primary, Lee, Tze Chuen, primary, Bezler, Martin, primary, Mann, Christian, primary, Gaertner, Silvia, primary, Hoefler, Heinz, primary, Iacobelli, Stefano, primary, Peter, Stephan, primary, Tay, Alice, primary, Brenner, Sydney, primary, Venkatesh, Byrappa, primary, and Ullrich, Axel, primary

Published
2023
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35. The octopus genome and the evolution of cephalopod neural and morphological novelties

Author

Albertin, Caroline B., Simakov, Oleg, Mitros, Therese, Wang, Z. Yan, Pungor, Judit R., Edsinger-Gonzales, Eric, Brenner, Sydney, Ragsdale, Clifton W., and Rokhsar, Daniel S.

Subjects
Octopus -- Genetic aspects -- Physiological aspects, Transcription factors, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Coleoid cephalopods (octopus, squid and cuttlefish) are active, resourceful predators with a rich behavioural repertoire (1). They have the largest nervous systems among the invertebrates (2) and present other striking morphological innovations including camera-like eyes, prehensile arms, a highly derived early embryogenesis and a remarkably sophisticated adaptive colouration system (1,3). To investigate the molecular bases of cephalopod brain and body innovations, we sequenced the genome and multiple transcriptomes of the California two-spot octopus, Octopus bimaculoides. We found no evidence for hypothesized whole-genome duplications in the octopus lineage (4-6). The core developmental and neuronal gene repertoire of the octopus is broadly similar to that found across invertebrate bilaterians, except for massive expansions in two gene families previously thought to be uniquely enlarged in vertebrates: the protocadherins, which regulate neuronal development, and the C2H2 superfamily of zinc-finger transcription factors. Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described (7), as well as in genes participating in a broad range of other cellular functions. We identified hundreds of cephalopod-specific genes, many of which showed elevated expression levels in such specialized structures as the skin, the suckers and the nervous system. Finally, we found evidence for large-scale genomic rearrangements that are closely associated with transposable element expansions. Our analysis suggests that substantial expansion of a handful of gene families, along with extensive remodelling of genome linkage and repetitive content, played a critical role in the evolution of cephalopod morphological innovations, including their large and complex nervous systems., Soft-bodied cephalopods such as the octopus (Fig. 1a) show remarkable morphological departures from the basic molluscan body plan, including dexterous arms lined with hundreds of suckers that function as specialized [...]

Published
2015

46. Elephant shark genome provides unique insights into gnathostome evolution

Author

Venkatesh, Byrappa, Lee, Alison P., Ravi, Vydianathan, Maurya, Ashish K., Lian, Michelle M., Swann, Jeremy B., Ohta, Yuko, Flajnik, Martin F., Sutoh, Yoichi, Kasahara, Masanori, Hoon, Shawn, Gangu, Vamshidhar, Roy, Scott W., Irimia, Manuel, Korzh, Vladimir, Kondrychyn, Igor, Lim, Zhi Wei, Tay, Boon-Hui, Tohari, Sumanty, Kong, Kiat Whye, Ho, Shufen, Lorente-Galdos, Belen, Quilez, Javier, Marques-Bonet, Tomas, Raney, Brian J., Ingham, Philip W., Tay, Alice, Hillier, LaDeana W., Minx, Patrick, Boehm, Thomas, Wilson, Richard K., Brenner, Sydney, and Warren, Wesley C.

Subjects
Nucleotide sequencing -- Methods, Immune system -- Genetic aspects, DNA sequencing -- Methods, Genomes -- Identification and classification, Sharks -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and immunoglobulin-based adaptive immunity. Gnathostomes subsequently diverged [...]

Published
2014
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