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2. Heart rate variability and stroke or systemic embolism in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Bhend, Katalin, Blum, Steffen, Bonati, Leo H., Carmine, Désirée, Conen, David, Eken, Ceylan, Fischer, Urs, Girroy, Corinne, Hennings, Elisa, Krisai, Philipp, Kühne, Michael, Mäder, Nina, Meyer-Zürn, Christine, Meyre, Pascal B., Monsch, Andreas U., Mosher, Luke, Müller, Christian, Osswald, Stefan, Paladini, Rebecca E., Peter, Raffaele, Schweigler, Adrian, Sticherling, Christian, Szucs, Thomas, Völlmin, Gian, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Netzer, Seraina, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Zarrabi Saffari, Tu Hanh, Rodondi, Nicolas, Reichlin, Tobias, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Murugiah, Samira, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Friedli, Corinne, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Caputo, Maria Luce, Peronaci, Rebecca, Regoli, Francois, Ronchi, Martina, Conte, Giulio, Brenner, Roman, Altmann, David, Fink, Karin, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Bühler, Kathrin, Justi, Virgina, Kellner-Weldon, Frauke, Koch, Melanie, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Kobza, Richard, Rigamonti, Elia, Cereda, Carlo, Cianfoni, Alessandro, De Perna, Maria Luisa, Frangi-Kultalahti, Jane, Mayer Melchiorre, Patrizia Assunta, Pin, Anica, Terrot, Tatiana, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Porretta, Alessandra Pia, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Aebersold, Helena, Foster, Fabienne, Schwenkglenks, Matthias, Düring, Marco, Sinnecker, Tim, Altermatt, Anna, Amann, Michael, Huber, Petra, Hürbin, Manuel, Ruberte, Esther, Thöni, Alain, Würfel, Jens, Zuber, Vanessa, Coslovsky (Head), Michael, Neuschwander, Pia, Simon, Patrick, Wunderlin, Olivia, Schmid, Ramun, Baumann, Christian, Hämmerle, Peter, Schlageter, Vincent, Coslovsky, Michael, Coduri, Federica, Blum, Manuel R., Stauber, Annina, Beer, Jürg, and Zuern, Christine S.

Published
2024
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4. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Aeschbacher, Stefanie, Auberson, Chloé, Blum, Steffen, Bonati, Leo, Ceylan, Selinda, Conen, David, Doerpfeld, Simone, Eken, Ceylan, Girod, Marc, Hämmerle, Peter, Krisai, Philipp, Kühne, Michael, Meyer-Zürn, Christine, Meyre, Pascal, Monsch, Andreas U., Müller, Christian, Osswald, Stefan, Springer, Anne, Sticherling, Christian, Szucs, Thomas, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fischer, Urs, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Loewe, Axel, Moutzouri, Elisavet, Schneider, Claudio, Flückiger, Tanja, Groen, Cindy, Ehrsam, Lukas, Hellrigl, Sven, Nuoffer, Alexandra, Rakovic, Damiana, Schwab, Nathalie, Wenger, Rylana, Rodondi, Nicolas, Beynon, Christopher, Dillier, Roger, Deubelbeiss, Michèle, Eberli, Franz, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Roth, Jasmin, Schlomowitsch, Fiona, Schneider, Xiaoye, Studerus, Katrin, Tynan, Noreen, Weishaupt, Dominik, Müller, Andreas, Fontana, Simone, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Grau, Alexandra, Villinger, Jonas, Laube, Eva, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Montrasio, Giulia, Leuenberger, Stefanie, Rutz, Franziska, Beer, Jürg-Hans, Auricchio, Angelo, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Gemperle, Michaela, Ammann, Peter, Firmann, Mathieu, Foucras, Sandrine, Rime, Martine, Hayoz, Daniel, Berte, Benjamin, Justi, Virgina, Kellner-Weldon, Frauke, Mehmann, Brigitta, Meier, Sonja, Roth, Myriam, Ruckli-Kaeppeli, Andrea, Russi, Ian, Schmidt, Kai, Young, Mabelle, Zbinden, Melanie, Kobza, Richard, Frangi-Kultalahti, Jane, Pin, Anica, Vicari, Luisa, Moschovitis, Giorgio, Ehret, Georg, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Tavel, Philippe, Teres, Cheryl, Shah, Dipen, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Schläpfer, Jürg, Grêt, Andrea, Novak, Jan, Vitelli, Sandra, Stephan, Frank-Peter, Gallino, Augusto, Di Valentino, Marcello, Witassek, Fabienne, Schwenkglenks, Matthias, Würfel, Jens, Altermatt, Anna, Amann, Michael, Huber, Petra, Ruberte, Esther, Sinnecker, Tim, Zuber, Vanessa, Coslovsky, Michael, Benkert, Pascal, Dutilh, Gilles, Markovic, Milica, Simon, Patrick, Schmid, Ramun, Beer, Jürg H., Bonati, Leo H., Blum, Manuel R., Kastner, Peter, and Baguley, Fiona

Published
2021
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6. Impact of the 2022 pulmonary hypertension definition on haemodynamic classification and mortality in patients with aortic stenosis undergoing valve replacement.

Author

Maeder, Micha T, Weber, Lukas, Pohle, Susanne, Chronis, Joannis, Baty, Florent, Rigger, Johannes, Brutsche, Martin, Haager, Philipp, Rickli, Hans, and Brenner, Roman

Subjects
AORTIC stenosis, PULMONARY hypertension, HEART valve prosthesis implantation, AORTIC valve transplantation, HEMODYNAMICS, PULMONARY artery
Abstract

Aims With the 2022 pulmonary hypertension (PH) definition, the mean pulmonary artery pressure (mPAP) threshold for any PH was lowered from ≥25 to >20 mmHg, and the pulmonary vascular resistance (PVR) value to differentiate between isolated post-capillary PH (IpcPH) and combined pre- and post-capillary PH (CpcPH) was reduced from >3 Wood units (WU) to >2 WU. We assessed the impact of this change in the PH definition in aortic stenosis (AS) patients undergoing aortic valve replacement (AVR). Methods and results Severe AS patients (n = 503) undergoing pre-AVR cardiac heart catheterization were classified according to both the 2015 and 2022 definitions. The post-AVR mortality [median follow-up 1348 (interquartile range 948–1885) days] was assessed. According to the 2015 definition, 219 (44% of the entire population) patients had PH: 63 (29%) CpcPH, 125 (57%) IpcPH, and 31 (14%) pre-capillary PH. According to the 2022 definition, 321 (+47%) patients were diagnosed with PH, and 156 patients (31%) were re-classified: 26 patients from no PH to IpcPH, 38 from no PH to pre-capillary PH, 38 from no PH to unclassified PH, 4 from pre-capillary PH to unclassified PH, and 50 from IpcPH to CpcPH (CpcPH: +79%). With both definitions, only the CpcPH patients displayed increased mortality (hazard ratios ≈ 4). Among the PH-defining haemodynamic components, PVR was the strongest predictor of death. Conclusion In severe AS, the application of the 2022 PH definition results in a substantially higher number of patients with any PH as well as CpcPH. With either definition, CpcPH patients have a significantly increased post-AVR mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Berger, Sebastian, Bernasconi, Raffaele, Fröhlich, Lorin, Göldi, Tobias, Gugganig, Rebecca, Kofler, Thomas, Krisai, Philipp, Mongiat, Michel, Pudenz, Christiane, Repilado, Javier Ruperti, Schweizer, Aleksandra, Springer, Anne, Stempfel, Samuel, Szucs, Thomas, van der Stouwe, Jan, Voellmin, Gian, Zwimpfer, Leon, Aujesky, Drahomir, Fuhrer, Juerg, Roten, Laurent, Jung, Simon, Mattle, Heinrich, Adam, Luise, Aubert, Carole Elodie, Feller, Martin, Schneider, Claudio, Loewe, Axel, Flückiger, Tanja, Groen, Cindy, Schwab, Nathalie, Beynon, Christopher, Dillier, Roger, Eberli, Franz, Fontana, Simone, Franzini, Christine, Juchli, Isabel, Liedtke, Claudia, Nadler, Jacqueline, Obst, Thayze, Schneider, Xiaoye, Studerus, Katrin, Weishaupt, Dominik, Kuest, Silke, Scheuch, Karin, Hischier, Denise, Bonetti, Nicole, Bello, Corina, Isberg, Henriette, Grau, Alexandra, Villinger, Jonas, Papaux, Mary-Monica, Baumgartner, Philipp, Filipovic, Mark, Frick, Marcel, Anesini, Adriana, Camporini, Cristina, Conte, Giulio, Caputo, Maria Luce, Regoli, Francois, Moccetti, Tiziano, Brenner, Roman, Altmann, David, Forrer, Manuela, Gemperle, Michaela, Firmann, Mathieu, Foucras, Sandrine, Berte, Benjamin, Kaeppeli, Andrea, Mehmann, Brigitta, Pfeiffer, Markus, Russi, Ian, Schmidt, Kai, Weberndoerfer, Vanessa, Young, Mabelle, Zbinden, Melanie, Vicari, Luisa, Frangi, Jane, Terrot, Tatiana, Gallet, Hervé, Guillermet, Elise, Lazeyras, Francois, Lovblad, Karl-Olof, Perret, Patrick, Teres, Cheryl, Lauriers, Nathalie, Méan, Marie, Salzmann, Sandrine, Arenja, Nisha, Grêt, Andrea, Vitelli, Sandra, Gallino, Augusto, Schoenenberger-Berzins, Renate, Witassek, Fabienne, Radue, Ernst-Wilhelm, Benkert, Pascal, Fabbro, Thomas, Simon, Patrick, Schmid, Ramun, Conen, David, Rodondi, Nicolas, Müller, Andreas, Beer, Juerg H., Ammann, Peter, Moschovitis, Giorgio, Auricchio, Angelo, Hayoz, Daniel, Kobza, Richard, Shah, Dipen, Novak, Jan, Schläpfer, Jürg, Di Valentino, Marcello, Aeschbacher, Stefanie, Blum, Steffen, Meyre, Pascal, Sticherling, Christian, Bonati, Leo H., Ehret, Georg, Moutzouri, Elisavet, Fischer, Urs, Monsch, Andreas U., Stippich, Christoph, Wuerfel, Jens, Sinnecker, Tim, Coslovsky, Michael, Schwenkglenks, Matthias, Kühne, Michael, and Osswald, Stefan

Published
2019
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8. ECG left ventricular hypertrophy in aortic stenosis: Relationship with cardiac structure, invasive hemodynamics, and long‐term mortality.

Author

Sager, Patrizia, Rusch, Andreas, Weber, Lukas, Breuss, Alexander, Appert, Sharon, Brenner, Roman, Buser, Marc, Ammann, Peter, Rickli, Hans, and Maeder, Micha T.

Subjects
LEFT ventricular hypertrophy, AORTIC stenosis, AORTIC valve transplantation, HEMODYNAMICS, ELECTROCARDIOGRAPHY, VASCULAR resistance
Abstract

Background: In aortic stenosis (AS), left ventricular hypertrophy (LVH) is the response to pressure overload and represents the substrate for a maladaptive cascade, the so‐called AS‐related cardiac damage. We hypothesized that in AS patients electrocardiogram (ECG) LVH not only predicts echocardiography LVH but also other noninvasive and invasive markers of cardiac damage and prognosis after aortic valve replacement (AVR). Methods: In 279 patients with severe AS undergoing ECG, echocardiography, and cardiac catheterization before AVR, the Sokolow‐Lyon index, the Cornell product, the Romhilt‐Estes score, and the Peguero‐Lo Presti score were assessed. Results: The mean left ventricular mass index was 109 ± 34 g/m2, and 131 (47%) patients had echocardiography LVH. The areas under the receiver operator characteristics curve (AUC) for the Sokolow‐Lyon index, the Cornell product, the Romhilt‐Estes score, and the Peguero‐Lo Presti score for the prediction of echocardiography LVH were 0.59, 0.70, 0.63, and 0.65. The Peguero‐Lo Presti score had the numerically greatest AUC for the prediction of left ventricular end‐diastolic pressure >15 mmHg, mean pulmonary artery wedge pressure >15 mmHg, pulmonary vascular resistance >3 Wood units, mean right atrial pressure >14 mmHg, and stroke volume index <31 mL/m2. After a median follow‐up of 1365 (interquartile range: 931–1851) days after AVR only the Peguero‐Lo Presti score was significantly associated with all‐cause mortality [hazard ratio: 1.24 (95% confidence interval: 1.01–1.54); per 1 mV increase; p =.045]. Conclusions: Among severe AS patients, the Peguero‐Lo Presti score is associated with abnormalities in cardiac structure including LVH, invasive measures of cardiac damage, and long‐term mortality after AVR. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

Author

Mills, Charlotte E., Flury, Andreas, Marmet, Cynthia, Poquet, Laura, Rimoldi, Stefano F., Sartori, Claudio, Rexhaj, Emrush, Brenner, Roman, Allemann, Yves, Zimmermann, Diane, Gibson, Glenn R., Mottram, Don S., Oruna-Concha, Maria-Jose, Actis-Goretta, Lucas, and Spencer, Jeremy P.E.

Published
2017
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10. Follow-up of CRT-D patients downgraded to CRT-P at the time of generator exchange

Author

Frey, Simon Martin, Brenner, Roman, Theuns, Dominic A., Al-Shoaibi, Naeem, Crawley, Richard J., Ammann, Peter, Sticherling, Christian, Kühne, Michael, Osswald, Stefan, Schaer, Beat, Frey, Simon Martin, Brenner, Roman, Theuns, Dominic A., Al-Shoaibi, Naeem, Crawley, Richard J., Ammann, Peter, Sticherling, Christian, Kühne, Michael, Osswald, Stefan, and Schaer, Beat

Abstract

Background: Some patients with cardiac resynchronisation therapy (CRT) experience super-response (LVEF improvements to ≥50%). At generator exchange (GE), downgrading (DG) from CRT-defibrillator (CRT-D) to CRT-pacemaker (CRT-P) could be an option for these patients on primary prevention ICD indication and no required ICD therapies. Long-term data on arrhythmic events in super-responders is scarce. Methods: CRT-D patients with LVEF improvement to ≥50% at GE were identified in four large centres for retrospective analysis. Mortality, significant ventricular tachyarrhythmia and appropriate ICD-therapy were determined, and patient analysis was split into two groups (downgraded to CRT-P or not). Results: Sixty-six patients (53% male, 26% coronary artery disease) on primary prevention were followed for a median of 129 months [IQR: 101–155] after implantation. 27 (41%) patients were downgraded to CRT-P at GE after a median of 68 [IQR: 58–98] months (LVEF 54% ± 4%). The other 39 (59%) continued with CRT-D therapy (LVEF 52% ± 6%). No cardiac death or significant arrhythmia occurred in the CRT-P group (median follow-up (FU) 38 months [IQR: 29–53]). Three appropriate ICD-therapies occurred in the CRT-D group [median FU 70 months (IQR: 39–97)]. Annualized event-rates after DG/GE were 1.5%/year and 1.0%/year in the CRT-D group and the whole cohort, respectively. Conclusions: No significant tachyarrhythmia were detected in the patients downgraded to CRT-P during follow-up. However, three events were observed in the CRT-D group. Whilst downgrading CRT-D patients is an option, a small residual risk for arrhythmic events remains and decisions regarding downgrade should be made on a case-by-case basis.

Published
2023

15. Systemic blood pressure in severe aortic stenosis: Haemodynamic correlates and long‐term prognostic impact.

Author

Maeder, Micha T., Rickli, Hans, Weber, Lukas, Weilenmann, Daniel, Ammann, Peter, Joerg, Lucas, Haager, Philipp K., Rigger, Johannes, Chronis, Joannis, and Brenner, Roman

Subjects
AORTIC stenosis, BLOOD pressure, HEMODYNAMICS, AORTIC valve transplantation, AMBULATORY blood pressure monitoring, VASCULAR resistance, RETENTION of urine, CYSTOMETRY, TRANSPOSITION of great vessels
Abstract

Aims: Blood pressure (BP) targets in patients with aortic stenosis (AS) are controversial. This study sought to describe the haemodynamic profile and the clinical outcome of severe AS patients with low versus high central meaarterial pressure (MAP). Methods and results: Patients with severe AS (n = 477) underwent right and left heart catheterization prior to aortic valve replacement (AVR). The population was divided into MAP quartiles. The mean systolic BP, diastolic BP, and MAP in the entire population were 149 ± 25, 68 ± 11, and 98 ± 14 mmHg. Patients in the lowest MAP quartile had the lowest left ventricular ejection fraction (LVEF), systemic vascular resistance, and valvulo‐arterial impedance, whereas there were no significant differences in mean right atrial pressure, mean pulmonary artery wedge pressure, pulmonary vascular resistance, and stroke volume index across MAP quartiles. However, left ventricular stroke work index (LVSWI) was lowest in patients in the lowest and highest in those in the highest MAP quartile. After a median (interquartile range) post‐AVR follow‐up of 3.7 (2.6–5.2) years, mortality was highest in patients in the lowest MAP quartile [hazard ratio 3.08 (95% confidence interval 1.21–7.83); P = 0.02 for lowest versus highest quartile]. In the multivariate analysis, lower MAP [hazard ratio 0.78 (95% confidence interval 0.62–0.99) per 10 mmHg increase; P = 0.04], higher mean right atrial pressure and lower LVEF were independent predictors of death. Conclusions: In severe AS patients, lower MAP reflects lower systemic vascular resistance and valvulo‐arterial impedance, which may help to preserve stroke volume and filling pressures despite reduced left ventricular performance, and lower MAP is a predictor of higher long‐term post‐AVR mortality. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Insulin-like growth factor-binding protein 7 and risk of congestive heart failure hospitalization in patients with atrial fibrillation

Author

Blum, Steffen, primary, Aeschbacher, Stefanie, additional, Meyre, Pascal, additional, Kühne, Michael, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Bonati, Leo H., additional, Blum, Manuel R., additional, Kastner, Peter, additional, Baguley, Fiona, additional, Sticherling, Christian, additional, Osswald, Stefan, additional, Conen, David, additional, Auberson, Chloé, additional, Blum, Steffen, additional, Bonati, Leo, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Eken, Ceylan, additional, Girod, Marc, additional, Hämmerle, Peter, additional, Krisai, Philipp, additional, Meyer-Zürn, Christine, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Szucs, Thomas, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Loewe, Axel, additional, Moutzouri, Elisavet, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Müller, Andreas, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Beer, Jürg-Hans, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Hayoz, Daniel, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Kobza, Richard, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Vicari, Luisa, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Shah, Dipen, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Schläpfer, Jürg, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Stephan, Frank-Peter, additional, Gallino, Augusto, additional, Di Valentino, Marcello, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Würfel, Jens, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Sinnecker, Tim, additional, Zuber, Vanessa, additional, Coslovsky, Michael, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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23. Radio-frequency ablation as primary management of well-tolerated sustained monomorphic ventricular tachycardia in patients with structural heart disease and left ventricular ejection fraction over 30%

Author

Maury, Philippe, Baratto, Francesca, Zeppenfeld, Katja, Klein, George, Delacretaz, Etienne, Sacher, Frederic, Pruvot, Etienne, Brigadeau, Francois, Rollin, Anne, Andronache, Marius, Maccabelli, Giuseppe, Gawrysiak, Marcin, Brenner, Roman, Forclaz, Andrei, Schlaepfer, Jürg, Lacroix, Dominique, Duparc, Alexandre, Mondoly, Pierre, Bouisset, Frederic, Delay, Marc, Hocini, Meleze, Derval, Nicolas, Sadoul, Nicolas, Magnin-Poull, Isabelle, Klug, Didier, Haïssaguerre, Michel, Jaïs, Pierre, Della Bella, Paolo, and De Chillou, Christian

Published
2014
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25. Blood Pressure and Brain Lesions in Patients With Atrial Fibrillation

Author

Aeschbacher, Stefanie, primary, Blum, Steffen, additional, Meyre, Pascal B., additional, Coslovsky, Michael, additional, Vischer, Annina S., additional, Sinnecker, Tim, additional, Rodondi, Nicolas, additional, Beer, Jürg H., additional, Moschovitis, Giorgio, additional, Moutzouri, Elisavet, additional, Hunkeler, Christof, additional, Burkard, Thilo, additional, Eken, Ceylan, additional, Roten, Laurent, additional, Zuern, Christine S., additional, Sticherling, Christian, additional, Wuerfel, Jens, additional, Bonati, Leo H., additional, Conen, David, additional, Osswald, Stefan, additional, Kühne, Michael, additional, Auberson, Chloé, additional, Ceylan, Selinda, additional, Doerpfeld, Simone, additional, Girod, Marc, additional, Hennings, Elisa, additional, Krisai, Philipp, additional, Monsch, Andreas U., additional, Müller, Christian, additional, Springer, Anne, additional, Voellmin, Gian, additional, Aujesky, Drahomir, additional, Fischer, Urs, additional, Fuhrer, Juerg, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Elodie Aubert, Carole, additional, Feller, Martin, additional, Loewe, Axel, additional, Schneider, Claudio, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Ehrsam, Lukas, additional, Hellrigl, Sven, additional, Nuoffer, Alexandra, additional, Rakovic, Damiana, additional, Schwab, Nathalie, additional, Wenger, Rylana, additional, Müller, Andreas, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Deubelbeiss, Michèle, additional, Eberli, Franz, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Roth, Jasmin, additional, Schlomowitsch, Fiona, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Tynan, Noreen, additional, Weishaupt, Dominik, additional, Fontana, Simone, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Laube, Eva, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Montrasio, Giulia, additional, Leuenberger, Stefanie, additional, Rutz, Franziska, additional, Moccetti, Tiziano, additional, Auricchio, Angelo, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Luce Caputo, Maria, additional, Regoli, Francois, additional, Ammann, Peter, additional, Brenner, Roman, additional, Altmann, David, additional, Gemperle, Michaela, additional, Hayoz, Daniel, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Rime, Martine, additional, Kobza, Richard, additional, Berte, Benjamin, additional, Justi, Virgina, additional, Kellner-Weldon, Frauke, additional, Mehmann, Brigitta, additional, Meier, Sonja, additional, Roth, Myriam, additional, Ruckli-Kaeppeli, Andrea, additional, Russi, Ian, additional, Schmidt, Kai, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Frangi-Kultalahti, Jane, additional, Pin, Anica, additional, Shah, Dipen, additional, Ehret, Georg, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Tavel, Philippe, additional, Teres, Cheryl, additional, Schläpfer, Jürg, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Stephan, Frank-Peter, additional, Grêt, Andrea, additional, Novak, Jan, additional, Vitelli, Sandra, additional, Di Valentino, Marcello, additional, Gallino, Augusto, additional, Witassek, Fabienne, additional, Schwenkglenks, Matthias, additional, Altermatt, Anna, additional, Amann, Michael, additional, Huber, Petra, additional, Ruberte, Esther, additional, Zuber, Vanessa, additional, Benkert, Pascal, additional, Dutilh, Gilles, additional, Markovic, Milica, additional, Neuschwander, Pia, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2021
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26. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients

Author

Pelliccia, Francesco, Parodi, Guido, Greco, Cesare, Antoniucci, David, Brenner, Roman, Bossone, Eduardo, Cacciotti, Luca, Capucci, Alessandro, Citro, Rodolfo, Delmas, Clément, Guerra, Federico, Ionescu, Costin N., Lairez, Olivier, Larrauri-Reyes, Maiteder, Lee, Pil Hyung, Mansencal, Nicolas, Marazzi, Giuseppe, Mihos, Christos G., Morel, Olivier, Nef, Holger M., Nunez Gil, Ivan J., Passaseo, Ilaria, Pineda, Andres M., Rosano, Giuseppe, Santana, Orlando, Schneck, Franziska, Song, Bong Gun, Song, Jae-Kwan, Teh, Andrew W., Ungprasert, Patompong, Valbusa, Alberto, Wahl, Andreas, Yoshida, Tetsuro, Gaudio, Carlo, and Kaski, Juan Carlos

Published
2015
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27. Use of the wearable cardioverter-defibrillator - the Swiss experience

Author

Kovacs, Boldizsar, Reek, Sven, Sticherling, Christian, Schaer, Beat, Linka, André, Ammann, Peter, Brenner, Roman, Krasniqi, Nazmi, Müller, Andreas S, Dzemali, Omer, Kobza, Richard, Grebmer, Christian, Haegeli, Laurent, Berg, Jan, Mayer, Kurt, Schläpfer, Jürg, Domenichini, Giulia, Reichlin, Tobias, Roten, Laurent, Burri, Harran, Eriksson, Urs, Saguner, Ardan M, Steffel, Jan, Duru, Firat, Swiss Wcd Registry, Kovacs, Boldizsar, Reek, Sven, Sticherling, Christian, Schaer, Beat, Linka, André, Ammann, Peter, Brenner, Roman, Krasniqi, Nazmi, Müller, Andreas S, Dzemali, Omer, Kobza, Richard, Grebmer, Christian, Haegeli, Laurent, Berg, Jan, Mayer, Kurt, Schläpfer, Jürg, Domenichini, Giulia, Reichlin, Tobias, Roten, Laurent, Burri, Harran, Eriksson, Urs, Saguner, Ardan M, Steffel, Jan, Duru, Firat, and Swiss Wcd Registry

Abstract

INTRODUCTION Sudden cardiac death caused by malignant arrhythmia can be prevented by the use of defibrillators. Although the wearable cardioverter defibrillator (WCD) can prevent such an event, its role in clinical practice is ill defined. We investigated the use of the WCD in Switzerland with emphasis on prescription rate, therapy adherence and treatment rate. MATERIALS AND METHODS The Swiss WCD Registry is a retrospective observational registry including patients using a WCD. Patients were included from the first WCD use in Switzerland until February 2018. Baseline characteristics and data on WCD usage were examined for the total study population, and separately for each hospital. RESULTS From 1 December 2011 to 18 February 2018, a total of 456 patients (67.1% of all WCDs prescribed in Switzerland and 81.1% of all prescribed in the participating hospitals) were included in the registry. Up to 2017 there was a yearly increase in the number of prescribed WCDs to a maximum of 271 prescriptions per year. The mean age of patients was 57 years (± 14), 81 (17.8%) were female and mean left ventricular ejection fraction (EF) was 32% (± 13). The most common indications for WCD use were new-onset ischaemic cardiomyopathy (ICM) with EF ≤35% (206 patients, 45.2%), new-onset nonischaemic cardiomyopathy (NICM) with EF ≤35% (115 patients, 25.2%), unknown arrhythmic risk (83 patients, 18.2%), bridging to implantable cardioverter-defibrillator implantation or heart transplant (37 patients, 8.1%) and congenital/inherited heart disease (15 patients, 3.3%). Median wear duration was 58 days (interquartile range [IQR] 31–94) with a median average daily wear time of 22.6 hours (IQR 20–23.2). Seventeen appropriate therapies from the WCD were delivered in the whole population (treatment rate: 3.7%) to a total of 12 patients (2.6% of all patients). The most common underlying heart disease in patients with a treatment was ICM (13/17, 76.5%). There were no inap

Published
2020

32. The Medtronic Sprint

Author

Frey, Simon Martin, Sticherling, Christian, Altmann, David, Brenner, Roman, Kühne, Michael, Ammann, Peter, Coslovsky, Michael, Osswald, Stefan, and Schaer, Beat

Abstract

Due to high failure rates, Medtronic withdrew the Sprint Fidelis lead (SFL) from the market. Passive fixation lead models exhibited better survival than active models, but most studies have limited follow-up. Aim of this study was to give insights into passive lead survival with a follow-up of 10 years.; In two large Swiss centers, patients with passive SFLs were identified and data from routine implantable cardioverter defibrillator (ICD) follow-ups were collected. Patients were censored at time of death, last device interrogation (if lost to follow-up), time of lead revision (in non-SFL-related problems), or at database closure (31th December 2017). We defined lead failure as any of the following: lead fracture with inappropriate discharge; sudden increase in low-voltage impedance to >1500 or high-voltage impedance to >100 Ω; >300 nonphysiological short VV-intervals.; We identified 145 patients. Age at implant was 60 ± 12 years with a median follow-up of 10.2 (interquartile range [IQR]: 5.0-11.2) years. Thirty-five percent of patients died after 5.4 ± 2.7 years. A total of 19 leads (13%) failed after 6.7 ± 3.2 years (range: 1.2-12.0). Overt malfunction with shocks existed in four patients (3%). Cumulative lead survival was 93.1% at 6, 88.2% at 8, 83.8% at 10, and 77.6% at 11 years, respectively, with 35% of implanted leads under monitoring at 10 years. Lead survival fits best a Weibull distribution with accelerating failure rates (k = 1.95, 95% CI 1.32-2.87, P < 0.001).; During very long-term follow-up, failure rate of the passive SFL shows an increase resulting in an impaired lead survival of 84% at 10 years.

Published
2019

33. Haemodynamic mechanisms and long-term prognostic impact of pulmonary hypertension in patients with severe aortic stenosis undergoing valve replacement

Author

Weber, Lukas, Rickli, Hans, Haager, Philipp K, Joerg, Lucas, Weilenmann, Daniel, Brenner, Roman, Taramasso, Maurizio, Baier, Philipp, Maisano, Francesco, Maeder, Micha T, University of Zurich, and Maeder, Micha T

Subjects
capillary Pulmonary capacitance Pulmonary Hypertension Wedge pressure, 610 Medicine & health, capillary Pre, 2705 Cardiology and Cardiovascular Medicine, Aortic Stenosis Post, 10020 Clinic for Cardiac Surgery
Published
2018

36. Relationships of Overt and Silent Brain Lesions With Cognitive Function in Patients With Atrial Fibrillation

Author

Conen, David, primary, Rodondi, Nicolas, additional, Müller, Andreas, additional, Beer, Juerg H., additional, Ammann, Peter, additional, Moschovitis, Giorgio, additional, Auricchio, Angelo, additional, Hayoz, Daniel, additional, Kobza, Richard, additional, Shah, Dipen, additional, Novak, Jan, additional, Schläpfer, Jürg, additional, Di Valentino, Marcello, additional, Aeschbacher, Stefanie, additional, Blum, Steffen, additional, Meyre, Pascal, additional, Sticherling, Christian, additional, Bonati, Leo H., additional, Ehret, Georg, additional, Moutzouri, Elisavet, additional, Fischer, Urs, additional, Monsch, Andreas U., additional, Stippich, Christoph, additional, Wuerfel, Jens, additional, Sinnecker, Tim, additional, Coslovsky, Michael, additional, Schwenkglenks, Matthias, additional, Kühne, Michael, additional, Osswald, Stefan, additional, Berger, Sebastian, additional, Bernasconi, Raffaele, additional, Fröhlich, Lorin, additional, Göldi, Tobias, additional, Gugganig, Rebecca, additional, Kofler, Thomas, additional, Krisai, Philipp, additional, Mongiat, Michel, additional, Pudenz, Christiane, additional, Repilado, Javier Ruperti, additional, Schweizer, Aleksandra, additional, Springer, Anne, additional, Stempfel, Samuel, additional, Szucs, Thomas, additional, van der Stouwe, Jan, additional, Voellmin, Gian, additional, Zwimpfer, Leon, additional, Aujesky, Drahomir, additional, Fuhrer, Juerg, additional, Roten, Laurent, additional, Jung, Simon, additional, Mattle, Heinrich, additional, Adam, Luise, additional, Aubert, Carole Elodie, additional, Feller, Martin, additional, Schneider, Claudio, additional, Loewe, Axel, additional, Flückiger, Tanja, additional, Groen, Cindy, additional, Schwab, Nathalie, additional, Beynon, Christopher, additional, Dillier, Roger, additional, Eberli, Franz, additional, Fontana, Simone, additional, Franzini, Christine, additional, Juchli, Isabel, additional, Liedtke, Claudia, additional, Nadler, Jacqueline, additional, Obst, Thayze, additional, Schneider, Xiaoye, additional, Studerus, Katrin, additional, Weishaupt, Dominik, additional, Kuest, Silke, additional, Scheuch, Karin, additional, Hischier, Denise, additional, Bonetti, Nicole, additional, Bello, Corina, additional, Isberg, Henriette, additional, Grau, Alexandra, additional, Villinger, Jonas, additional, Papaux, Mary-Monica, additional, Baumgartner, Philipp, additional, Filipovic, Mark, additional, Frick, Marcel, additional, Anesini, Adriana, additional, Camporini, Cristina, additional, Conte, Giulio, additional, Caputo, Maria Luce, additional, Regoli, Francois, additional, Moccetti, Tiziano, additional, Brenner, Roman, additional, Altmann, David, additional, Forrer, Manuela, additional, Gemperle, Michaela, additional, Firmann, Mathieu, additional, Foucras, Sandrine, additional, Berte, Benjamin, additional, Kaeppeli, Andrea, additional, Mehmann, Brigitta, additional, Pfeiffer, Markus, additional, Russi, Ian, additional, Schmidt, Kai, additional, Weberndoerfer, Vanessa, additional, Young, Mabelle, additional, Zbinden, Melanie, additional, Vicari, Luisa, additional, Frangi, Jane, additional, Terrot, Tatiana, additional, Gallet, Hervé, additional, Guillermet, Elise, additional, Lazeyras, Francois, additional, Lovblad, Karl-Olof, additional, Perret, Patrick, additional, Teres, Cheryl, additional, Lauriers, Nathalie, additional, Méan, Marie, additional, Salzmann, Sandrine, additional, Arenja, Nisha, additional, Grêt, Andrea, additional, Vitelli, Sandra, additional, Gallino, Augusto, additional, Schoenenberger-Berzins, Renate, additional, Witassek, Fabienne, additional, Radue, Ernst-Wilhelm, additional, Benkert, Pascal, additional, Fabbro, Thomas, additional, Simon, Patrick, additional, and Schmid, Ramun, additional

Published
2019
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39. Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction

Author

Brenner, Roman, primary, Ammann, Peter, additional, Yoon, See-Il, additional, Christen, Stefan, additional, Hellermann, Jens, additional, Girod, Grégoire, additional, Knaus, Urs, additional, Duru, Firat, additional, Krasniqi, Nazmi, additional, Ramsay, David, additional, Sticherling, Christian, additional, Lippuner, Kurt, additional, and Kühne, Michael, additional

Published
2016
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40. Haemodynamic mechanisms and long-term prognostic impact of pulmonary hypertension in patients with severe aortic stenosis undergoing valve replacement.

Author

Weber, Lukas, Rickli, Hans, Haager, Philipp K., Joerg, Lucas, Weilenmann, Daniel, Brenner, Roman, Taramasso, Maurizio, Baier, Philipp, Maisano, Francesco, and Maeder, Micha T.

Subjects
VENTRICULAR ejection fraction, MITRAL valve insufficiency, PERCUTANEOUS balloon valvuloplasty, CARDIAC catheterization, AORTIC valve, PULMONARY hypertension, PULMONARY artery, AORTIC stenosis, PROSTHETIC heart valves, HEMODYNAMICS, LONGITUDINAL method, PROGNOSIS, TIME, DISEASE prevalence, RETROSPECTIVE studies, DISEASE complications
Abstract

Aims: We aimed to investigate the prevalence, detailed invasive haemodynamics, and prognostic impact of pulmonary hypertension (PH) in severe aortic stenosis (AS).Methods and Results: We studied 503 patients (mean age 74 ± 10 years) with severe AS (indexed aortic valve area 0.4 ± 0.1 cm2 /m2 , left ventricular ejection fraction 57 ± 12%) undergoing left and right heart catheterization prior to aortic valve replacement. Median follow-up was 3.7 (interquartile range 2.6-5.4) years. Baseline PH (mean pulmonary artery pressure ≥ 25 mmHg) was found in 239 (48%) patients: 31 patients had pre-capillary PH [mean pulmonary artery wedge pressure (mPAWP) ≤ 15 mmHg], 144 had isolated post-capillary PH [IpcPH; mPAWP > 15 mmHg, pulmonary vascular resistance (PVR) ≤ 3 Wood units (WU)], and 64 had combined pre- and post-capillary PH (CpcPH; mPAWP > 15 mmHg, PVR > 3 WU). Patients with CpcPH had higher mortality than those with IpcPH, pre-capillary PH, and without PH. In the multivariate analysis, CpcPH remained an independent predictor of death (hazard ratio 4.39, 95% confidence interval 2.40-8.03; P < 0.001). Patients with CpcPH had higher mPAWP (26 ± 7 vs. 22 ± 5 mmHg) and lower pulmonary arterial capacitance (1.5 ± 0.6 vs. 2.9 ± 1.2 mL/mmHg) than IpcPH patients but similar left ventricular end-diastolic pressure (LVEDP; 25 ± 7 vs. 25 ± 7 mmHg). A smaller LVEDP-mPAWP difference was related to larger left atrial size, atrial fibrillation, and more severe mitral regurgitation.Conclusions: In patients with severe AS, PH is common but underlying mechanisms differ. Patients with CpcPH have higher mPAWP, lower pulmonary arterial capacitance, and worse survival than all other groups. Left atrial dysfunction and mitral regurgitation seem to be drivers of high mPAWP in CpcPH. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Effect of patent foramen ovale closure on obstructive sleep apnea

Author

Ott, Sebastian, primary, Rimoldi, Stefano, additional, Rexhaj, Emrush, additional, Von Arx, Robert, additional, Di Marchi, Stefano, additional, Brenner, Roman, additional, Scherrer, Urs, additional, Meier, Bernhard, additional, Gugger, Matthias, additional, Allemann, Yves, additional, and Seiler, Christian, additional

Published
2015
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44. Effect of Patent Foramen Ovale Closure on Obstructive Sleep Apnea

Author

Rimoldi, Stefano F., primary, Ott, Sebastian R., additional, Rexhaj, Emrush, additional, von Arx, Robert, additional, de Marchi, Stefano F., additional, Brenner, Roman, additional, Scherrer, Urs, additional, Meier, Bernhard, additional, Gugger, Matthias, additional, Allemann, Yves, additional, and Seiler, Christian, additional

Published
2015
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45. Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction.

Author

Brenner, Roman, Ammann, Peter, See-Il Yoon, Christen, Stefan, Hellermann, Jens, Girod, Grégoire, Knaus, Urs, Duru, Firat, Krasniqi, Nazmi, Ramsay, David, Sticherling, Christian, Lippuner, Kurt, Kühne, Michael, and Yoon, See-Il

Abstract

Aims: Elderly patients with sinus node dysfunction (SND) are at increased risk of falls with possible injuries. However, the incidence of these adverse events and its reduction after permanent pacemaker (PPM) implantation are not known.Methods and Results: Eighty-seven patients (mean [SD] age 75.4 [8.3] years, 51% women) with SND and an indication for cardiac pacing were included and were examined by a standardized interview targeting fall history. The incidence and total number of falls, falls with injury, falls requiring treatment, and falls resulting in a fracture were assessed for the time period of 12 months before (retrospectively) and after PPM implantation (prospectively). Furthermore, symptoms such as syncope, dizziness, and dyspnea were evaluated before and after PPM implantation. The implantation of a PPM was associated with a reduced proportion of patients experiencing at least one fall by 71% (from 53 to 15%, P < 0.001) and a reduction of the absolute number of falls by 90% (from 127 to 13, P < 0.001) during the 12 months before vs. after PPM implant. Falls with injury (28 vs. 10%, P = 0.005), falls requiring medical attention (31 vs. 8%, P < 0.001), and falls leading to fracture (8 vs. 0%, P = 0.013) were similarly reduced. Notably, fewer patients had syncope (4 vs. 45%, P < 0.001) and dizziness after PPM implantation (12 vs. 45%, P < 0.001).Conclusion: Falls, fall-related injuries, and fall-related fractures are frequent in SND patients. Permanent pacemaker implantation is associated with a significantly reduced risk of these adverse events, although no causal relationship could be established due to the study design. [ABSTRACT FROM AUTHOR]

Published
2017
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50. RV Contractility and Exercise-Induced Pulmonary Hypertension in Chronic Mountain Sickness

Author

Pratali, Lorenza, primary, Allemann, Yves, additional, Rimoldi, Stefano F., additional, Faita, Francesco, additional, Hutter, Damian, additional, Rexhaj, Emrush, additional, Brenner, Roman, additional, Bailey, Damian M., additional, Sartori, Claudio, additional, Salmon, Carlos Salinas, additional, Villena, Mercedes, additional, Scherrer, Urs, additional, Picano, Eugenio, additional, and Sicari, Rosa, additional

Published
2013
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