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4. A Novel Validation Framework to Assess Segmentation Accuracy of Inertial Sensor Data for Rehabilitation Exercises

Author

Brennan, Louise, Bevilacqua, Antonio, Kechadi, Tahar, Caulfield, Brian, Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Jarm, Tomaz, editor, Cvetkoska, Aleksandra, editor, Mahnič-Kalamiza, Samo, editor, and Miklavcic, Damijan, editor

Published
2021
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7. Physical Therapists in Oncology Settings: Experiences in Delivering Cancer Rehabilitation Services, Barriers to Care, and Service Development Needs

Author

Brennan, Louise, Sheill, Grainne, O'Neill, Linda, O'Connor, Louise, Smyth, Emily, and Guinan, Emer

Subjects
Cancer -- Care and treatment, Physical therapists -- Services, Health
Abstract

Objective. Physical therapist-delivered rehabilitation aims to manage the side effects of cancer and its treatments. Although access to cancer rehabilitation is not yet a standard of care in many countries, physical therapists practice in many types of cancer services with different cancer populations. The purpose of this study was to explore the experiences of physical therapists in cancer care practice with regard to their role, the factors influencing service delivery and development, and physical therapists' professional development needs. Methods. In this qualitative study with semistructured interviews, physical therapists in cancer care settings in the Republic of Ireland were interviewed via telephone. Participants (n = 17) represented a variety of clinical settings and roles. Two researchers performed thematic analysis of transcriptions using a semantic, inductive approach. Key themes and codes were identified and illustrative quotes were selected. Results. Six main themes were found: the need for more services, barriers to service development and delivery, a lack of awareness of the role of physical therapy, facilitators to service development, goals for the future of oncology physical therapy, and training needs of staff. Conclusions. Physical therapists provide valuable interventions across the spectrum of cancer care but experience barriers to the delivery and development of services. Investment in oncology physical therapy and developing international standards of care will allow physical therapists to meet the rehabilitation needs of survivors of cancer. Impact. As international guidelines increasingly recommend development of cancer rehabilitation programs, it is important to understand physical therapists' experiences of working in cancer care to assist in the development of effective oncology physical therapy services. This study demonstrates that physical therapist-led cancer rehabilitation services need investment and public promotion to enable the provision of optimal services to all patients with cancer and to meet standards of care. Keywords: Cancer Rehabilitation, Oncology, Physical Therapy, Qualitative, Introduction Advances in cancer diagnosis and treatment, along with growing and aging populations, have resulted in an increased number of cancer survivors worldwide. (1,2) This pattern means that more people [...]

Published
2022
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17. Recycling plastics from waste computer equipment

Author

Brennan, Louise B.

Subjects
668.9
Abstract

In light of recent European legislation, an increase in recycling and recovery activities is required in the electrical and electronic sector in order to meet stipulated targets. For waste plastics this also includes the separation of plastics containing brominated flame retardants from those that do not. Studies into the FTIR (Fourier transform infrared) spectra of a collection of plastics from waste housings for computer equipment and comparisons with spectra from a selection of flame retardants, as well as testing different plastics identification systems have concluded that infrared spectroscopy cannot be used to detect flame retardants in plastics in the current state of technology. However flame retardants may be detected by using a combination of identification techniques such as IR (infrared) for plastic identification and pyrolytic spectroscopy for additive detection. The effects of recycling and blending on a commercial scale have been assessed on mechanical properties of the four most used plastics in computer equipment housings. Recycled ABS (acrylonitrile-butadiene-styrene), HIPS (high impact polystyrene), modified PPO (polyphenylene oxide) and PC (polycarbonate) /ABS alloy were tested in the pure form and as various blends of ABS and HIPS, HIPS and modified PPO (mPPO), ABS with PC/ABS and a blend of all four plastics. Properties tested were tensile and impact properties, DMT A (dynamic mechanical thermal analysis), viscosity, molecular weight and surface and bulk microscopy. Generally changes to mechanical properties following recycling of pure ABS, HIPS, PPO and PC/ABS are quite small, although there are slight reductions in ductility for HIPS and mPPO. All plastics used in this study appear unaffected by the presence of a small proportion of another plastic, although at higher blend proportions impact strengths of ABS/PC/ABS deteriorate, properties of ABS/HIPS blends remain unaffected and larger proportions of HIPS/PPO are beneficial to all properties. These results indicate that a plastics identification system probably does not need to be exactly 100% accurate.

Published
2004

21. Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2‐ mediated recombination in the melanocyte lineage

Author

Wilkinson, Emma L., primary, Brennan, Louise C., additional, Harrison, Olivia J., additional, Crane‐Smith, Zoe, additional, Gautier, Philippe, additional, Keighren, Margaret A., additional, Budd, Peter, additional, Swaminathan, Karthic, additional, Machesky, Laura M., additional, Allinson, Sarah L., additional, Jackson, Ian J., additional, and Mort, Richard L., additional

Published
2022
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23. A genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2 mediated recombination in the melanocyte lineage:A targeted Pmel allele driving CreERT2 expression in melanocytes

Author

Wilkinson, Emma L, Brennan, Louise C, Harrison, Olivia J, Crane-Smith, Zoe, Gautier, Philippe, Keighren, Margaret A, Budd, Peter, Swaminathan, Karthic, Machesky, Laura M, Allinson, Sarah L, Jackson, Ian J, and Mort, Richard L

Subjects
keratinocytes, melanocytes, melanoma, melanoblasts
Abstract

Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of the Tyrosinase and Dopachrome tautomerase genes, knock-in to the Dopachrome tautomerase locus or knock-in to the Mlana locus in a bacterial artificial chromosome. These strategies result in expression in other tissues such as telencephalon and other cell types such as nerves. Here we used homologous recombination in mouse embryonic stem cells to generate a targeted multicistronic allele of the Pmel locus that drives melanocyte-specific expression of CreERT2, nuclear localised H2B-Cerulean and membrane localised marcks-mKate2 allowing live imaging of melanocytes and activation of other conditional alleles. We combined this allele with R26R-EYFP mice allowing induction of EYFP expression on administration of tamoxifen or its metabolite 4-OHT. The fluorescent proteins H2B-Cerulean and marcks-mKate2 label the cell nucleus and plasma membrane respectively allowing live imaging and FACS isolation of melanoblasts and melanocytes as well as serving to provide an internal control allowing estimation of recombination efficiency after administration of tamoxifen. We demonstrate the utility of the transgene in embryonic and adult tissues.

Published
2022

25. Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study

Author

Brennan, Louise, primary, Sadeghi, Fatemeh, additional, O’Neill, Linda, additional, Guinan, Emer, additional, Smyth, Laura, additional, Sheill, Grainne, additional, Smyth, Emily, additional, Doyle, Suzanne L., additional, Timon, Claire M., additional, Connolly, Deirdre, additional, O’Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2022
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26. Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2‐mediated recombination in the melanocyte lineage.

Author

Wilkinson, Emma L., Brennan, Louise C., Harrison, Olivia J., Crane‐Smith, Zoe, Gautier, Philippe, Keighren, Margaret A., Budd, Peter, Swaminathan, Karthic, Machesky, Laura M., Allinson, Sarah L., Jackson, Ian J., and Mort, Richard L.

Subjects
*BACTERIAL artificial chromosomes, *ALLELES, *BACTERIAL loci, *EMBRYONIC stem cells, *CELL nuclei
Abstract

Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of the Tyrosinase and Dopachrome tautomerase genes, knock‐in to the Dopachrome tautomerase locus or knock‐in to the Mlana locus in a bacterial artificial chromosome. These strategies result in expression in other tissues such as telencephalon and other cell types such as nerves. Here we used homologous recombination in mouse embryonic stem cells to generate a targeted multicistronic allele of the Pmel locus that drives melanocyte‐specific expression of CreERT2, nuclear localised H2B‐Cerulean and membrane localised marcks‐mKate2 allowing live imaging of melanocytes and activation of other conditional alleles. We combined this allele with R26R‐EYFP mice allowing induction of EYFP expression on administration of tamoxifen or its metabolite 4‐OHT. The fluorescent proteins H2B‐Cerulean and marcks‐mKate2 label the cell nucleus and plasma membrane respectively allowing live imaging and FACS isolation of melanoblasts and melanocytes as well as serving to provide an internal control allowing estimation of recombination efficiency after administration of tamoxifen. We demonstrate the utility of the transgene in embryonic and adult tissues. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Cystatin M/E variant causes autosomal dominant keratosis follicularis spinulosa decalvans by dysregulating cathepsins L and V

Author

Eckl, Katja M., Gruber, Robert, Brennan, Louise, Marriott, Andrew, Plank, Roswitha, Moosbrugger-Martinz, Verena, Blunder, Stefan, Schossig, Anna, Altmüller, Janine, Thiele, Holger, Nürnberg, Peter, Zschocke, Johannes, Hennies, Hans Christian, and Schmuth, Matthias

Subjects
transglutaminase, congenital disorder of cornification, cicatricial alopecia, Genetics, keratosis follicularis spinulosa decalvans, cathepsin, Technology Platforms, cystatin, epidermal differentiation, Original Research
Abstract

Keratosis follicularis spinulosa decalvans (KFSD) is a rare cornification disorder with an X-linked recessive inheritance in most cases. Pathogenic variants causing X-linked KFSD have been described in MBTPS2, the gene for a membrane-bound zinc metalloprotease that is involved in the cleavage of sterol regulatory element binding proteins important for the control of transcription. Few families have been identified with an autosomal dominant inheritance of KFSD. We present two members of an Austrian family with a phenotype of KFSD, a mother and her son. The disease was not observed in her parents, pointing to a dominant inheritance with a de novo mutation in the index patient. Using whole-exome sequencing, we identified a heterozygous missense variant in CST6 in DNA samples from the index patient and her affected son. In line with family history, the variant was not present in samples from her parents. CST6 codes for cystatin M/E, a cysteine protease inhibitor. Patient keratinocytes showed increased expression of cathepsin genes CTSL and CTSV and reduced expression of transglutaminase genes TGM1 and TGM3. A relative gain of active, cleaved transglutaminases was found in patient keratinocytes compared to control cells. The variant found in CST6 is expected to affect protein targeting and results in marked disruption of the balance between cystatin M/E activity and its target proteases and eventually transglutaminases 1 and 3. This disturbance leads to an impairment of terminal epidermal differentiation and proper hair shaft formation seen in KFSD.

Published
2021

31. Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V

Author

Eckl, Katja M., primary, Gruber, Robert, additional, Brennan, Louise, additional, Marriott, Andrew, additional, Plank, Roswitha, additional, Moosbrugger-Martinz, Verena, additional, Blunder, Stefan, additional, Schossig, Anna, additional, Altmüller, Janine, additional, Thiele, Holger, additional, Nürnberg, Peter, additional, Zschocke, Johannes, additional, Hennies, Hans Christian, additional, and Schmuth, Matthias, additional

Published
2021
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32. ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol

Author

O'Neill, Linda, primary, Guinan, Emer, additional, Brennan, Louise, additional, Doyle, Suzanne L., additional, O'Connor, Louise, additional, Sheill, Grainne, additional, Smyth, Emily, additional, Fairman, Ciaran M., additional, Segurado, Ricardo, additional, Connolly, Deirdre, additional, O'Sullivan, Jacintha, additional, Reynolds, John V., additional, and Hussey, Juliette, additional

Published
2021
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40. A Research Roadmap: Connected Health as an Enabler of Cancer Patient Support

Author

Signorelli, Gabriel Ruiz, primary, Lehocki, Fedor, additional, Mora Fernández, Matilde, additional, O'Neill, Gillian, additional, O'Connor, Dominic, additional, Brennan, Louise, additional, Monteiro-Guerra, Francisco, additional, Rivero-Rodriguez, Alejandro, additional, Hors-Fraile, Santiago, additional, Munoz-Penas, Juan, additional, Bonjorn Dalmau, Mercè, additional, Mota, Jorge, additional, Oliveira, Ricardo B, additional, Mrinakova, Bela, additional, Putekova, Silvia, additional, Muro, Naiara, additional, Zambrana, Francisco, additional, and Garcia-Gomez, Juan M, additional

Published
2019
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45. A Research Roadmap: Connected Health as an Enabler of Cancer Patient Support (Preprint)

Author

Signorelli, Gabriel Ruiz, primary, Lehocki, Fedor, additional, Mora Fernández, Matilde, additional, O'Neill, Gillian, additional, O'Connor, Dominic, additional, Brennan, Louise, additional, Monteiro-Guerra, Francisco, additional, Rivero-Rodriguez, Alejandro, additional, Hors-Fraile, Santiago, additional, Munoz-Penas, Juan, additional, Bonjorn Dalmau, Mercè, additional, Mota, Jorge, additional, Oliveira, Ricardo B, additional, Mrinakova, Bela, additional, Putekova, Silvia, additional, Muro, Naiara, additional, Zambrana, Francisco, additional, and Garcia-Gomez, Juan M, additional

Published
2019
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49. Short term effects of castration on steroid metabolism

Author

Brennan Louise

Subjects
Anyagcsere, Metabolism, Dog, Ivari működés, Steroids, Sex, Castration, Ivartalanítás, Szteroidok, Kutya, Szülészeti-tanszék
Abstract

The purpose of this study was to measure the short term effects of castration on steroid metabolism in male shelter dogs. Blood samples were obtained from 20 male dogs that were part of an on-going neutering program run at Szent Istvan Univeristy, Faculty of Veterinary Science, Budapest, Hungary. Two blood samples were obtained from the individual dogs prior to and post castration. Serum concentrations were determined in both samples for progesterone, pregnenolone, 17α-hydroxyprogesterone, di-hydrotestosterone (DHT), testosterone, oestrogen, cortisol and corticosterone. Prior to the surgery the intact male dogs had greater concentrations of DHT, testosterone, progesterone, pregnenolone and oestrogen. Blood steroid concentrations measured after the surgery demonstrated a significant increase in cortisol, corticosterone and 17α-hydroxyprogesterone levels, where P

Published
2016

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