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9. A genome-wide scan reveals candidate susceptibility loci for pig hernias in an intercross between White Duroc and Erhualian

Author

Ding, N.S., Mao, H.R., Guo, Y.M., Ren, J., Xiao, S.J., Wu, G.Z., Shem, H.Q., Wu, L.H., Ruam, G.F., Brenig, B., and Huang, L.S.

Subjects
Hernia -- Genetic aspects, Swine -- Genetic aspects, Zoology and wildlife conservation
Abstract

Pig scrotal/inguinal and umbilical hernias are the most prevalent congenital disorders in pigs and often cause animal welfare problems and economic loss. To identify susceptibility loci for these traits, a genome-wide scan with 194 microsatellite markers covering the pig genome was performed in a White Duroc x Erhualian resource population with 23 scrotal/ inguinal [F.sub.2] animals, 50 umbilical [F.sub.2] animals, and their unaffected siblings. A sex-average linkage map with a total length of 2,350.3 cM and an average marker interval of 12.84 cM was constructed. Both nonparametrie genome-wide linkage (NPL) analysis and transmission disequilibrium test (TDT) were implemented to detect closely linked markers. The NPL analysis revealed 11 chromosomal regions on SSC1, 2, 3, 6, 7, 8, 10, and 11 for umbilical hernia and 5 regions on SSC2, 4, 8, 13, and 16 for scrotal/inguinal hernia, whereas the TDT test identified susceptibility loci for umbilical hernia on SSC1, 2, 4, 7, 10, 13, 14, and 15 and for scrotal/inguinal hernias on SSC2, 8, 10, and 18. The most promising loci were SWR1928 on SSC7 and SW830 on SSC10 for umbilical hernia, and SW933 on SSC8 for scrotal hernia, which were consistently detected by both NPL and TDT. Several previously reported chromosomal regions for scrotal/inguinal hernia were confirmed, and new evidence for linkage with this pig defect was found. Moreover, susceptibility loci for pig umbilical hernia were detected for the first time. Key words: hernia, pig, susceptibility loci

Published
2009

10. A whole genome scan for quantitative trait loci for leg weakness and its related traits in a large [F.sub.2] intercross population between White Duroc and Erhualian

Author

Guo, Y.M., Ai, H.S., Ren, J., Wang, G.J., Wen, Y., Mao, H.R., Lan, L.T., Ma, J.W., Brenig, B., Rothschild, M.F., Haley, C.S., and Huang, L.S.

Subjects
Animal development -- Genetic aspects, Swine -- Genetic aspects, Quantitative trait loci -- Research, Zoology and wildlife conservation
Abstract

To detect QTL for leg weakness and its related traits in pigs, a total of 1,484 [F.sub.2] pigs were recorded for leg (at 76 and 213 d) and gait scores (at 153 and 223 d) in a White Duroc x Erhualian intercross. The length and weight of the biceps brachii muscle were measured after slaughter at 240 d. A genome scan was performed with 183 microsatellite markers in the population. A total of 42 QTL were detected, including 16 at the 1% genome-wide significant level and 6 at the 5% genome-wide significant level. Thirty-eight of the 42 QTL showed significant additive effects, and 14 had significant dominance effects. At least 2 QTL were detected for each trait except for leg score at 76 d, for which no QTL was identified. Some of the QTL for leg and gait scores confirmed previous findings. Eighteen QTL were detected for weight and length of the biceps brachii nmscle. To our knowledge, this was the first report about QTL for weight and length of the biceps brachii muscle in pigs. Two chromosome regions each on SSC4 and SSC7 showed significant and multiple associations with both leg weakness and growth of the biceps brachii muscle, which are worthwhile for further investigation. Key words: biceps brachii muscle, gait score, leg score, pig, quantitative trait loci

Published
2009

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