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1. Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial.

Author

Oh, Justin, Skinner, Lawrie, Gutkin, Paulina, Jiang, Alice, Donaldson, Sarah, Loo, Billy, Wang, Yi, Ewongwo, Agnes, Bredfeldt, Jeremy, Breneman, John, Constine, Louis, Faught, Austin, Haas-Kogan, Daphne, Holmes, Jordan, Krasin, Matthew, Larkin, Charlene, Marcus, Karen, Maxim, Peter, McClelland, Shearwood, Murphy, Blair, Palmer, Joshua, Perkins, Stephanie, Shen, Colette, Terezakis, Stephanie, Bush, Karl, and Hiniker, Susan

Abstract

PURPOSE: The Audiovisual-Assisted Therapeutic Ambience in Radiotherapy (AVATAR) trial was a prospective multicenter study (NCT03991156) examining the combination of video immersion with radiation therapy and was successfully conducted through the collaboration of pediatric radiation oncology teams at 10 institutions independent of any pre-existing consortium. We sought to analyze and report the methodology of trial conception and development, process map, and cost. METHODS AND MATERIALS: The study enrolled patients aged 3 to 10 years preparing to undergo radiation therapy, integrated the combination of AVATAR-based video immersion with radiation therapy at each institution, and offered AVATAR use as an alternative to anesthesia, with rates of anesthesia use and outcomes of serial standardized anxiety and quality-of-life assessments assessed among the 81 children enrolled. A process map was created based on the trial timeline with the following components: study development time (time from conception of the trial to the accrual of the first patient, including design phase, agreement and approval phase, and site preparation phase), and accrual duration time (time from the first to last accrual). Costs and institutional success rates were calculated. RESULTS: Time from inception of study to last accrual was 3.6 years (1313 days). The study development time was 417 days (31.7%), and accrual duration time was 896 days (68.3%), with the final 50% of accrual occurring in

Published
2024

2. Feasibility of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) System for Anesthesia Avoidance in Pediatric Patients: A Multicenter Trial.

Author

Gutkin, Paulina M, Skinner, Lawrie, Jiang, Alice, Donaldson, Sarah S, Loo, Billy W, Oh, Justin, Wang, Yi Peng, von Eyben, Rie, Snyder, John, Bredfeldt, Jeremy S, Breneman, John C, Constine, Louis S, Faught, Austin M, Haas-Kogan, Daphne, Holmes, Jordan A, Krasin, Matthew, Larkin, Charlene, Marcus, Karen J, Maxim, Peter G, McClelland, Shearwood, Murphy, Blair, Palmer, Joshua D, Perkins, Stephanie M, Shen, Colette J, Terezakis, Stephanie, Bush, Karl, and Hiniker, Susan M

Subjects
Pediatric, Clinical Research, Clinical Trials and Supportive Activities, Management of diseases and conditions, 7.1 Individual care needs, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThe Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) system was the first published radiation therapy (RT)-compatible system to reduce the need for pediatric anesthesia through video-based distraction. We evaluated the feasibility of AVATAR implementation and effects on anesthesia use, quality of life, and anxiety in a multicenter pediatric trial.Methods and materialsPediatric patients 3 to 10 years of age preparing to undergo RT at 10 institutions were prospectively enrolled. Children able to undergo at least 1 fraction of RT using AVATAR without anesthesia were considered successful (S). Patients requiring anesthesia for their entire treatment course were nonsuccessful (NS). The PedsQL3.0 Cancer Module (PedsQL) survey assessed quality of life and was administered to the patient and guardian at RT simulation, midway through RT, and at final treatment. The modified Yale Preoperative Anxiety Scale (mYPAS) assessed anxiety and was performed at the same 3 time points. Success was evaluated using the χ2 test. PedsQL and mYPAS scores were assessed using mixed effects models with time points evaluated as fixed effects and a random intercept on the subject.ResultsEighty-one children were included; median age was 7 years. AVATAR was successful at all 10 institutions and with photon and proton RT. There were 63 (78%) S patients; anesthesia was avoided for a median of 20 fractions per patient. Success differed by age (P = .04) and private versus public insurance (P < .001). Both patient (P = .008) and parent (P = .006) PedsQL scores significantly improved over the course of RT for patients aged 5 to 7. Anxiety in the treatment room decreased for both S and NS patients over RT course (P < .001), by age (P < .001), and by S versus NS patients (P < .001).ConclusionsIn this 10-center prospective trial, anesthesia avoidance with AVATAR was 78% in children aged 3 to 10 years, higher than among age-matched historical controls (49%; P < .001). AVATAR implementation is feasible across multiple institutions and should be further studied and made available to patients who may benefit from video-based distraction.

Published
2023

4. Factors associated with radiation necrosis and intracranial control in patients treated with immune checkpoint inhibitors and stereotactic radiotherapy

Author

Hall, Jacob, Lui, Kevin, Tan, Xianming, Shumway, John, Collichio, Frances, Moschos, Stergios, Sengupta, Soma, Chaudhary, Rekha, Quinsey, Carolyn, Jaikumar, Sivakumar, Forbes, Jonathan, Andaluz, Norberto, Zuccarello, Mario, Struve, Timothy, Vatner, Ralph, Pater, Luke, Breneman, John, Weiner, Ashley, Wang, Kyle, and Shen, Colette

Published
2023
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5. A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

Author

DeWire, Mariko, Fuller, Christine, Hummel, Trent R., Chow, Lionel M. L., Salloum, Ralph, de Blank, Peter, Pater, Luke, Lawson, Sarah, Zhu, Xiaoting, Dexheimer, Phil, Carle, Adam C., Kumar, Shiva Senthil, Drissi, Rachid, Stevenson, Charles B., Lane, Adam, Breneman, John, Witte, David, Jones, Blaise V., Leach, James L., and Fouladi, Maryam

Published
2020
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6. Gliomas in Children

Author

Meier, Teresa, Freeman, Carolyn, Breneman, John, Lee, Nancy Y., Series Editor, Lu, Jiade J., Series Editor, Terezakis, Stephanie A., editor, and MacDonald, Shannon M., editor

Published
2019
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17. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study

Author

Daugherty, Emily C, primary, Mascia, Anthony, additional, Zhang, Yong, additional, Lee, Eunsin, additional, Xiao, Zhiyan, additional, Sertorio, Mathieu, additional, Woo, Jennifer, additional, McCann, Claire, additional, Russell, Kenneth, additional, Levine, Lisa, additional, Sharma, Ricky, additional, Khuntia, Deepak, additional, Bradley, Jeffrey, additional, Simone II, Charles B, additional, Perentesis, John, additional, and Breneman, John, additional

Published
2023
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18. Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases

Author

Mascia, Anthony E., primary, Daugherty, Emily C., additional, Zhang, Yongbin, additional, Lee, Eunsin, additional, Xiao, Zhiyan, additional, Sertorio, Mathieu, additional, Woo, Jennifer, additional, Backus, Lori R., additional, McDonald, Julie M., additional, McCann, Claire, additional, Russell, Kenneth, additional, Levine, Lisa, additional, Sharma, Ricky A., additional, Khuntia, Dee, additional, Bradley, Jeffrey D., additional, Simone, Charles B., additional, Perentesis, John P., additional, and Breneman, John C., additional

Published
2023
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20. 45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy: A report from the Soft Tissue Sarcoma Committee of the Childrenʼs Oncology Group

Author

Ermoian, Ralph P., Breneman, John, Walterhouse, David O., Chi, Yueh‐Yun, Meza, Jane, Anderson, James, Hawkins, Douglas S., Hayes‐Jordan, Andrea A., Parham, David M., Yock, Torunn I., Donaldson, Sarah S., and Wolden, Suzanne L.

Published
2017
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24. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study (Preprint)

Author

Daugherty, Emily C, primary, Mascia, Anthony E, additional, Zhang, Yongbin, additional, Lee, Eunsin, additional, Xiao, Zhiyan, additional, Sertorio, Mathieu, additional, Woo, Jennifer, additional, McCann, Claire, additional, Russell, Ken, additional, Levine, Lisa L, additional, Sharma, Ricky A, additional, Khuntia, Deepak, additional, Bradley, Jeffrey, additional, Simone 2nd, Charles B, additional, Perentesis, John P, additional, and Breneman, John C, additional

Published
2022
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25. EPCT-05. Phase Ib study of unesbulin (PTC596) in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): A report from the COllaborative Network for NEuro-Oncology Clinical Trials (CONNECT)

Author

Lazow, Margot A, primary, Baxter, Patricia, additional, Stanek, Joseph, additional, Lane, Adam, additional, Rodriguez, Diana P, additional, Kumar, Shiva Senthil, additional, Leach, James L, additional, Mikael, Leonie, additional, Fuller, Christine, additional, Boué, Daniel R, additional, Pierson, Christopher R, additional, Thomas, Diana, additional, Breneman, John, additional, Palmer, Joshua, additional, Li, Xiao-Nan, additional, Salloum, Ralph, additional, Ashley, David, additional, de Blank, Peter, additional, Hwang, Eugene, additional, Leary, Sarah E S, additional, Plant, Ashley, additional, Crabtree, Dorothy, additional, Wahba, Mona, additional, Weetall, Marla, additional, Baird, John, additional, Leonard, Jeffrey, additional, Stewart, Clinton F, additional, Mardis, Elaine, additional, Fouladi, Maryam, additional, and Drissi, Rachid, additional

Published
2022
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26. Contributors

Author

Abrams, Ross A., primary, Adelstein, David J., additional, Alektiar, Kaled M., additional, Alexander, Brian, additional, Alsner, Jan, additional, Altun, Ersan, additional, Anderson, Bethany, additional, Ang, K. Kian, additional, Arthur, Douglas W., additional, Ashman, Jonathan B., additional, Ballo, Matthew T., additional, Barker, Christopher Andrew, additional, Beadle, Beth M., additional, Bedard, Phillipe, additional, Beitler, Jonathan J., additional, Bishop, Michael W., additional, Blackstock, A. William, additional, Bogart, Jeffrey A., additional, Bonner, James A., additional, Bourland, J. Daniel, additional, Bovi, Joseph, additional, Breneman, John, additional, Brito, Juan P., additional, Brown, Paul D., additional, Brundage, Michael D., additional, Buchholz, Thomas A., additional, Burmeister, Bryan Henry, additional, Calderwood, Stuart K., additional, Callister, Matthew D., additional, Calvo, Felipe A., additional, Cannon, George M., additional, Chabner, Bruce A., additional, Chan, Michael D., additional, Chao, Sam T., additional, Charpentier, Anne-Marie, additional, Chung, Christine H., additional, Chung, Peter W.M., additional, Constine, Louis S., additional, Corn, Benjamin W., additional, Covens, Allan, additional, Craciunescu, Oana I., additional, Crane, Christopher H., additional, Creutzberg, Carien L., additional, Crook, Juanita M., additional, Curran, Walter J., additional, Czito, Brian G., additional, Dabaja, Bouthaina S., additional, Das, Shiva, additional, David, Marc, additional, Dawson, Laura A., additional, DeLaney, Thomas F., additional, Devlin, Phillip M., additional, Dewhirst, Mark, additional, Dizon, Don S., additional, Dome, Jeffrey S., additional, Donohue, John H., additional, Duprez, Thierry P., additional, Efstathiou, Jason A., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, Feng, Mary, additional, Fernandes, Rui P., additional, Fielding, Julia R., additional, Fleming, Gini F., additional, Foote, Robert L., additional, Fraass, Benedick A., additional, Freeman, Carolyn R., additional, Garden, Adam S., additional, Gentry, Lindell R., additional, Gien, Lilian T., additional, Gospodarowicz, Mary K., additional, Grau, Cai, additional, Grégoire, Vincent, additional, Greven, Craig M., additional, Greven, Kathryn McConnell, additional, Gunderson, Leonard L., additional, Haddock, Michael G., additional, Halyard, Michele, additional, Hamoir, Marc, additional, Hanna, Timothy Paul, additional, Harari, Paul M., additional, Hay, Ian D., additional, Herman, Joseph M., additional, Holloway, Caroline L., additional, Hong, Theodore Sunki, additional, Horowitz, Neil S., additional, Horseman, Michael R., additional, Howle, Julie, additional, Hrycushko, Brian A., additional, Hsu, David, additional, Hudgins, Patricia A., additional, Hutchinson, Ryan C., additional, Iacobuzio-Donahue, Christine, additional, Izar, Benjamin, additional, Jewells, Valerie L., additional, Jurcic, Joseph Gerard, additional, Kalapurakal, John A., additional, Kavanagh, Brian D., additional, Kelly, Kara M., additional, Khandani, Amir H., additional, Khuntia, Deepak, additional, Kiess, Ana Ponce, additional, Knox, Susan J., additional, Koh, Wui-Jin, additional, Krasin, Matthew J., additional, Kun, Larry E., additional, Laack, Nadia Issa, additional, LaCasce, Ann S., additional, Langer, Corey Jay, additional, Laramore, George E., additional, Lassman, Andrew B., additional, Lawton, Colleen A.F., additional, Lee, Nancy, additional, Lengelé, Benoît, additional, Levin, William P., additional, Lindegaard, Jacob C., additional, Lucas, John T., additional, MacDonald, Shannon M., additional, Mackillop, William J., additional, Mahindra, Anuj, additional, Mancuso, Anthony A., additional, Marcus, Karen Jean, additional, Marks, Lawrence B., additional, Matceyevsky, Diana, additional, Mazeron, Jean-Jacques, additional, McDonald, Mark W., additional, Medin, Paul M., additional, Mehta, Minesh P., additional, Mendenhall, William M., additional, Meredith, Ruby F., additional, Michalski, Jeff M., additional, Milano, Michael T., additional, Minsky, Bruce D., additional, Morrison, William H., additional, Murphy, Erin S., additional, Murthy, Rashmi K., additional, Ng, Andrea K., additional, Nordsmark, Marianne, additional, O'Farrell, Desmond A., additional, Okunieff, Paul, additional, Ove, Roger, additional, Overgaard, Jens, additional, Palta, Manisha, additional, Parker, Alexander S., additional, Pater, Luke E., additional, Peterson, Jennifer L., additional, Pisansky, Thomas M., additional, Potters, Louis, additional, Quon, Harry, additional, Raben, David, additional, Recht, Abram, additional, Rengan, Ramesh, additional, Reyngold, Marsha, Laufer, additional, Riaz, Nadeem, additional, Roberts, Stephen S., additional, Roberts, Kenneth B., additional, Rockhill, Jason K., additional, Rödel, Claus M., additional, Rodriguez-Galindo, Carlos, additional, Rogers, C. Leland, additional, Rosenblat, Todd L., additional, Rule, William G., additional, Russell, Anthony Henryk, additional, Russo, Suzanne, additional, Ryan, David P., additional, Sandlund, John Torsten, additional, Sandow, Pamela L., additional, Sargent, Daniel J., additional, Schild, Steven E., additional, Seegenschmiedt, Michael Heinrich, additional, Shah, Chirag, additional, Shaw, Edward G., additional, Sheehan, Jason P., additional, Sheikh, Arif, additional, Shi, Qian, additional, Siker, Malika L., additional, Small, William, additional, Smith, Benjamin D., additional, Smith, Grace L., additional, Solberg, Timothy D., additional, Stauffer, Paul R., additional, Stevenson, Mary Ann, additional, Stewart, Alexandra J., additional, Suh, John H., additional, Tan, Winston W., additional, Tepper, Joel E., additional, Thomas, Charles R., additional, Thomas, Gillian M., additional, Timmerman, Robert D., additional, Tsang, Richard W., additional, Usuki, Kenneth Y., additional, Valentini, Vincenzo, additional, Valero, Vicente, additional, van den Bent, Martin J., additional, Veness, Michael J., additional, Vicini, Frank A., additional, Vicus, Danielle, additional, Viswanathan, Akila N., additional, Vujaskovic, Zeljko, additional, Wadsworth, J. Trad, additional, Wagner, Henry, additional, Wahl, Daniel R., additional, Warde, Padraig R., additional, Waxweiler, Timothy V., additional, Wehle, Michael J., additional, Weil, Robert J., additional, Weiss, Lawrence M., additional, Werning, John W., additional, Willett, Christopher G., additional, Willey, Christopher Douglas, additional, Wilson, Lynn D., additional, Winkfield, Karen M., additional, Yon-Li, Jennifer, additional, Wolden, Suzanne L., additional, Wong, Terence Z., additional, Wong, Jeffrey Y.C., additional, Wong, William W., additional, Wu, Wenting, additional, Yahalom, Joachim, additional, Yang, Eddy Shih-Hsin, additional, You, Y. Nancy, additional, Zeman, Elaine M., additional, Zeng, Jing, additional, and Zietman, Anthony L., additional

Published
2016
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29. Practice Patterns of Pediatric Total Body Irradiation Techniques: A Children's Oncology Group Survey

Author

Rassiah, Prema, primary, Esiashvili, Natia, additional, Olch, Arthur J., additional, Hua, Chia-Ho, additional, Ulin, Ken, additional, Molineu, Andrea, additional, Marcus, Karen, additional, Gopalakrishnan, Mahesh, additional, Pillai, Susha, additional, Kovalchuk, Nataliya, additional, Liu, An, additional, Niyazov, Greg, additional, Peñagarícano, Jose, additional, Cheung, Fred, additional, Olson, Adam C., additional, Wu, Cheng-Chia, additional, Malhotra, Harish K., additional, MacEwan, Iain J., additional, Faught, Jacqueline, additional, Breneman, John C., additional, Followill, David S., additional, FitzGerald, Thomas J., additional, and Kalapurakal, John A., additional

Published
2021
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34. In Regard to Buchsbaum et al

Author

Breneman, John, primary, Perentesis, John P., additional, Bradley, Jeffrey, additional, Mascia, Anthony, additional, Abel, Eric, additional, Sharda, Agam, additional, Khuntia, Deepak, additional, Sharma, Ricky A., additional, and Simone, Charles B., additional

Published
2021
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36. Environmental monitoring for biological threat agents using the autonomous pathogen detection system with multiplexed polymerase chain reaction

Author

Regan, John F., Makarewicz, Anthony J., Hindson, Benjamin J., Metz, Thomas R., Gutierrez, Dora M., Corzett, Todd H., Hadley, Dean R., Mahnke, Ryan C., Henderer, Bruce D., Breneman, John W., IV, Weisgraber, Todd H., and Dzenitis, John M.

Subjects
Polymerase chain reaction -- Methods, Environmental monitoring -- Methods, Environmental monitoring -- Equipment and supplies, Biological weapons -- Control, Pathology -- Research, Chemistry
Abstract

We have developed and field-tested a now operational civilian biodefense capability that continuously monitors the air in high-risk locations for biological threat agents. This stand-alone instrument, called the Autonomous Pathogen Detection System (APDS), collects and selectively concentrates particles from the air into liquid samples and analyzes the samples using multiplexed PCR amplification coupled with microsphere array detection. During laboratory testing, we evaluated the APDS instrument's response to Bacillus anthracis and Yersinia pestis by spiking the liquid sample stream with viable spores and cells, bead-beaten lysates, and purified DNA extracts. APDS results were also compared to a manual real-time PCR method. Field data acquired during 74 days of continuous operation at a mass-transit subway station are presented to demonstrate the specificity and reliability of the APDS. The U.S. Department of Homeland Security recently selected the APDS reported herein as the first autonomous detector component of their BioWatch antiterrorism program. This sophisticated field-deployed surveillance capability now generates actionable data in one-tenth the time of manual filter collection and analysis.

Published
2008

37. Rhabdomyosarcoma

Author

MS Radiotherapie, Cancer, Yechieli, Raphael L., Mandeville, Henry C., Hiniker, Susan M., Bernier-Chastagner, Valerie, McGovern, Susan, Scarzello, Giovanni, Wolden, Suzanne, Cameron, Alison, Breneman, John, Fajardo, Raquel Davila, Donaldson, Sarah S., MS Radiotherapie, Cancer, Yechieli, Raphael L., Mandeville, Henry C., Hiniker, Susan M., Bernier-Chastagner, Valerie, McGovern, Susan, Scarzello, Giovanni, Wolden, Suzanne, Cameron, Alison, Breneman, John, Fajardo, Raquel Davila, and Donaldson, Sarah S.

Published
2021

42. Rhabdomyosarcoma

Author

Yechieli, Raphael L., primary, Mandeville, Henry C., additional, Hiniker, Susan M., additional, Bernier‐Chastagner, Valerie, additional, McGovern, Susan, additional, Scarzello, Giovanni, additional, Wolden, Suzanne, additional, Cameron, Alison, additional, Breneman, John, additional, Fajardo, Raquel Davila, additional, and Donaldson, Sarah S., additional

Published
2021
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44. Contributors

Author

Abrams, Ross A., primary, Alonso-Basanta, Michelle, additional, Anderson, Bethany M., additional, Anderson, Kenneth C., additional, Ang, K. Kian, additional, Arthur, Douglas W., additional, Avey, Gregory D., additional, Ballo, Matthew T., additional, Barker, Christopher A., additional, Baszkowsky, Lawrence S., additional, Beitler, Jonathan J., additional, Blackstock, A. William, additional, Bogart, Jeffrey A., additional, Bonner, James A., additional, Bourland, J. Daniel, additional, Breneman, John, additional, Brown, Paul D., additional, Buchholz, Thomas A., additional, Buchsbaum, Jeffrey C., additional, Burke, Michael, additional, Buskirk, Steven J., additional, Calderwood, Stuart K., additional, Callister, Matthew D., additional, Calvo, Felipe A., additional, Cannon, George M., additional, Catton, Charles, additional, Chabner, Bruce A., additional, Chan, Michael D., additional, Chao, Sam T., additional, Chung, Peter, additional, Coen, John J., additional, Constine, Louis S., additional, Corn, Benjamin W., additional, Covens, Allan, additional, Craciunescu, Oana, additional, Creutzberg, Carien L., additional, Crook, Juanita, additional, Curran, Walter J., additional, Czito, Brian G., additional, Das, Shiva, additional, David, Marc, additional, DeLaney, Thomas F., additional, Dewhirst, Mark, additional, Dickie, Colleen, additional, Dome, Jeffrey S., additional, Donohue, John H., additional, Duprez, Thierry, additional, Dutta, Pinaki, additional, Efstathiou, Jason A., additional, Eisbruch, Avraham, additional, Feng, Mary, additional, Fernandes, Rui P., additional, Fielding, Julia R., additional, Fleming, Gini F., additional, Foote, Robert L., additional, Fraass, Benedick A., additional, Garden, Adam S., additional, Gentry, Lindell R., additional, Ghilezan, Michel, additional, Gospodarowicz, Mary K., additional, Grau, Cai, additional, Grégoire, Vincent, additional, Greven, Craig M., additional, Greven, Kathryn McConnell, additional, Gunderson, Leonard L., additional, Haddock, Michael G., additional, Hamoir, Marc, additional, Harari, Paul M., additional, Hay, Ian D., additional, Hertzfeld, Kara, additional, Hogg, David, additional, Horsman, Michael R., additional, Hudgins, Patricia A., additional, Hudson, Melissa M., additional, Jewells, Valerie S., additional, Jolly, Shruti, additional, Jones, Glenn, additional, Kalapurakal, John A., additional, Khandani, Amir H., additional, Khuntia, Deepak, additional, Knox, Susan J., additional, Koh, Wui-Jin, additional, Krasin, Matthew J., additional, Kuban, Deborah A., additional, Kun, Larry E., additional, LaCasce, Ann S., additional, Laramore, George E., additional, Lassman, Andrew B., additional, Laufer, Marsha, additional, Lavigne, Ruth, additional, Lawrence, Theodore S., additional, Lawton, Colleen A., additional, Lee, Nancy, additional, Lengelé, Benoît, additional, Levin, William P., additional, Lin, Alexander, additional, Lindegaard, Jacob C., additional, Mackillop, William J., additional, Mahindra, Anuj, additional, Mancuso, Anthony A., additional, Marcus, Karen J., additional, Marks, Lawrence B., additional, Martenson, James A., additional, Martinez, Alvaro A., additional, Mauch, Peter, additional, Mazeron, Jean-Jacques, additional, McHaffie, Derek R., additional, Mehta, Minesh P., additional, Mendenhall, William M., additional, Merchant, Thomas E., additional, Meredith, Ruby F., additional, Michalski, Jeff, additional, Milano, Michael T., additional, Bonner Millar, Lara P., additional, Minsky, Bruce D., additional, Moore, David H., additional, Morrison, William H., additional, Newman, Jason G., additional, Ng, Andrea K., additional, Nordsmark, Marianne, additional, Offerman, Shannon, additional, Okunieff, Paul, additional, O’Neil, Bert, additional, O'Sullivan, Brian, additional, Ove, Roger, additional, Overgaard, Jens, additional, Parker, Alexander S., additional, Paulussen, Michael, additional, Petersen, Ivy A., additional, Peterson, Jennifer L., additional, Pisansky, Thomas M., additional, Porter, Arthur T., additional, Potters, Louis, additional, Pugh, Thomas J., additional, Quon, Harry, additional, Raben, David, additional, Recht, Abram, additional, Rengan, Ramesh, additional, Roberts, Kenneth B., additional, Rockhill, Jason K., additional, Rödel, Claus, additional, Rodriguez-Galindo, Carlos, additional, Rogers, C. Leland, additional, Russell, Anthony H., additional, Russo, Suzanne, additional, Sandlund, John T., additional, Sandow, Pamela R., additional, Sargent, Daniel J., additional, Sartor, Carolyn I., additional, Schifter, Dan, additional, Schild, Steven E., additional, Schuck, Andreas, additional, Seegenschmiedt, Michael Heinrich, additional, Shah, Anand P., additional, Shaw, Edward G., additional, Sheikh, Arif, additional, Shipley, William U., additional, Siker, Malika L., additional, Siu, Lillian L., additional, Small, William, additional, Smith, Benjamin D., additional, Stauffer, Paul, additional, Stevenson, Mary Ann, additional, Stieber, Volker W., additional, Suh, John H., additional, Supko, Jeffrey G., additional, Tan, Winston W., additional, Tepper, Joel E., additional, Thomas, Charles R., additional, Thomas, Gillian M., additional, Thrall, Donald, additional, Tomé, Wolfgang, additional, Tsang, Richard W., additional, Valentini, Vincenzo, additional, van den Bendt, Martin J., additional, Van der Zee, Ate G.J., additional, Veness, Michael J., additional, Vicini, Frank A., additional, Vicus, Danielle, additional, Vujaskovic, Zeljko, additional, Wadsworth, J. Trad, additional, Wagner, Henry, additional, Warde, Padraig R., additional, Wehle, Michael J., additional, Weil, Robert J., additional, Weiss, Jared, additional, Weiss, Lawrence, additional, Werning, John W., additional, Willett, Christopher G., additional, Willey, Christopher D., additional, Wilson, Lynn D., additional, Wolden, Suzanne, additional, Wong, Jeffrey Y.C., additional, Wong, William W., additional, Wu, Wenting, additional, Yahalom, Joachim, additional, You, Y. Nancy, additional, Zeman, Elaine M., additional, and Zietman, Anthony L., additional

Published
2012
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45. Rare Pediatric Tumors

Author

Lavigne, Ruth, primary, Hertzfeld, Kara, additional, Offerman, Shannon, additional, and Breneman, John, additional

Published
2012
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47. Long-term effects of total skin electron beam therapy for mycosis fungoides on hair and nail loss and regrowth.

Author

Breneman, Debra L., Breneman, Alyssa, Ballman, Elaine, and Breneman, John C.

Subjects
MYCOSIS fungoides, ELECTRON beams, BALDNESS
Abstract

To better document the risk of permanent hair and nail loss after total skin electron beam therapy (TSEBT) for mycosis fungoides (MF). Interviews and evaluations were conducted in 13 patients with MF treated with TSEBT alone and two patients treated with concomitant TSEBT and chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Evaluated parameters included time to hair and nail loss and regrowth, the density of hair regrowth, and quality of hair and nail regrowth. Most patients had complete loss of scalp hair during treatment, and new growth appeared about 2 months following treatment completion. After 18 months, most patients felt their hair had regrown to about 70% of baseline thickness without cosmetically obvious alopecia. The patients treated with TSEBT and concomitant chemotherapy had substantially less scalp hair regrowth with persistent cosmetically obvious alopecia. Some lost eyebrows and eyelashes, but complete or near-complete regrowth generally occurred. Most patients lost their nails following TSEBT, with complete regrowth noted by most patients 5 months after treatment. New nails were most often normal, but a few patients developed post-therapy nail dystrophies. This data can be used to better inform patients of likely long-term changes of hair and nails following TSEBT. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Improving the Pediatric Patient Experience During Radiation Therapy-A Children’s Oncology Group Study

Author

Holt, Douglas E., primary, Hiniker, Susan M., additional, Kalapurakal, John A., additional, Breneman, John C., additional, Shiao, Jay C., additional, Boik, Nicole, additional, Cooper, Benjamin T., additional, Dorn, Paige L., additional, Hall, Matthew D., additional, Logie, Natalie, additional, Lucas, John T., additional, MacEwan, Iain J., additional, Olson, Adam C., additional, Palmer, Joshua D., additional, Patel, Samir, additional, Pater, Luke E., additional, Surgener, Stephanie, additional, Tsang, Derek S., additional, Vogel, Jennifer H., additional, Wojcik, Alyssa, additional, Wu, Cheng-Chia, additional, and Milgrom, Sarah A., additional

Published
2021
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