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576 results on '"Brendel, K."'

1. An analysis of the fluctuations of the geomagnetic dipole

Author

Brendel, K., Kuipers, J., Barkema, G. T., and Hoyng, P.

Subjects
Physics - Geophysics
Abstract

The time evolution of the strength of the Earth's virtual axial dipole moment (VADM) is analyzed by relating it to the Fokker-Planck equation, which describes a random walk with VADM-dependent drift and diffusion coefficients. We demonstrate first that our method is able to retrieve the correct shape of the drift and diffusion coefficients from a time series generated by a test model. Analysis of the Sint-2000 data shows that the geomagnetic dipole mode has a linear growth time of 13 to 33 kyr, and that the nonlinear quenching of the growth rate follows a quadratic function of the type [1-(x/x0)^2]. On theoretical grounds, the diffusive motion of the VADM is expected to be driven by multiplicative noise, and the corresponding diffusion coefficient to scale quadratically with dipole strength. However, analysis of the Sint-2000 VADM data reveals a diffusion which depends only very weakly on the dipole strength. This may indicate that the magnetic field quenches the amplitude of the turbulent velocity in the Earth's outer core., Comment: 11 pages, 6 figures

Published
2007
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2. Nucleation times in the 2D Ising model

Author

Brendel, K., Barkema, G. T., and van Beijeren, H.

Subjects
Condensed Matter - Statistical Mechanics
Abstract

A theoretical framework is presented for the estimation of nucleation times in systems with Brownian type dynamics. This framework is applied to a prototype system: the two-dimensional Ising model with spin-flip dynamics in an external magnetic field. Direct simulation results for the nucleation times, spanning more than four orders of magnitude, are compared with theoretical predictions. There are no free parameters; all system properties required by the theory are determined by simulations in equilibrium systems. Theoretical and simulation values are found to agree in most cases within 20%., Comment: 8 pages, 6 figures

Published
2003

3. Akustik

Author

Martin, R., Dämmig, P., Brinkmann, K., Brendel, K., Kohlrausch, F., Kose, Volkmar, editor, Wagner, Siegfried, editor, Bortfeldt, J., editor, Dietze, G., editor, Dorenwendt, K., editor, German, S., editor, Hemminger, W., editor, Martin, R., editor, Melchert, F., editor, Scharmann, A., editor, Schuster, H.-J., editor, Seyfried, P., editor, Sievert, J. D., editor, Aschenbrenner, A., editor, Bachmair, H., editor, Beyer, W., editor, Biermann, M., editor, Blanke, W., editor, de Boer, H., editor, Braun, A., editor, Brendel, K., editor, Brinkmann, K., editor, Cammenga, H., editor, Dämmig, P., editor, Gläser, M., editor, Gorski, W., editor, Hammerschmidt, U., editor, Hanke, R., editor, Hinken, J., editor, Jacob, A., editor, Jäger, J., editor, Janik, D., editor, Jescheck, M., editor, Jung, H.-J., editor, Kessel, W., editor, Kind, D., editor, Klingenberg, G., editor, Kremer, F., editor, Lange, G., editor, Lohrengel, J., editor, Maas, H., editor, Mann, R., editor, Meerlender, G., editor, Messer, G., editor, Müller, K., editor, Münter, K., editor, Narjes, L., editor, Polzin, T., editor, Quaß, M., editor, Ramm, G., editor, Sarge, S. M., editor, Sawla, A., editor, Scholz, G., editor, Seemann, F. W., editor, Sommer, K.-D., editor, Spieweck, F., editor, Stumper, U., editor, Vollmer, E., editor, Wagenbreth, H., editor, and Zander, M., editor

Published
1996
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12. Excimer laser crystallization of amorphous silicon on molybdenum coated glass substrates

Author

Brendel, K., Fuhs, W., Lengsfeld, P., Nerding M., Sieber, I., Strunk, H.P., Schopke, A., and Nickel, N.H.

Subjects
Molybdenum -- Optical properties, Silicon -- Optical properties, Metallic glasses -- Research, Excimer lasers -- Usage, Physics
Abstract

Excimer laser was used to crystallize (a -Si:H) film on molybdenum (Mo) coated glass substrate. This does not result in intermixing of Mo and Si.

Published
2002

13. 1793P RESILIENT part 1: Pharmacokinetics of second-line (2L) liposomal irinotecan in patients with small cell lung cancer (SCLC)

Author

Ponce, S., primary, Brendel, K., additional, Spigel, D.R., additional, Chen, Y., additional, Jove Casulleras, M., additional, Juan-Vidal, O., additional, Rich, P., additional, Hayes, T., additional, Gutiérrez Calderón, V., additional, Bernabe Caro, R., additional, Navarro, A., additional, Dowlati, A., additional, Zhang, B., additional, Moore, Y., additional, Kokhreidze, J., additional, Pedret-Dunn, A., additional, Paz-Ares, L., additional, and Bunn, P.A., additional

Published
2020
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16. Efficiency of EPI cluster sampling for assessing diarrhoea and dysentery prevalence

Author

Yoon, S.S., Katz, J., Brendel, K., and West, K.P., Jr.

Subjects
Diarrhea -- Demographic aspects, Dysentery -- Demographic aspects, Prevalence studies (Epidemiology) -- Analysis
Abstract

This study examines the efficiency of EPI cluster sampling in assessing the prevalence of diarrhoea and dysentery. A computer was used to simulate fieldwork carried out by a survey taker. The bias and variance of prevalence estimates obtained using EPI cluster sampling were compared with those obtained using simple random sampling and cluster (stratified random) sampling. Efficiency ratios, calculated as the mean square error divided by total distance travelled, were used to compare EPI cluster sampling to simple random sampling and standard cluster sampling. EPI cluster sampling may be an appropriate low-cost tool for monitoring trends in the prevalence of diarrhoea and dysentery over time. However, it should be used with caution when estimating the prevalence of diarrhoea at a single point in time because of the bias associated with this cluster sampling method., Introduction Diarrhoea is one of the major causes of morbidity and mortality among children in developing countries. It has been estimated that over 12000 persons die each day from diarrhoeal [...]

Published
1997

29. Exogenous Lipocalin 2 Ameliorates Acute Rejection in a Mouse Model of Renal Transplantation

Author

Ashraf, M. I., Schwelberger, H. G., Brendel, K. A., Feurle, J., Andrassy, J., Kotsch, K., Regele, H., Pratschke, J., Maier, H. T., and Aigner, F.

Subjects
Graft Rejection, Male, Mice, Knockout, animal models: murine, rejection: acute, Mice, Inbred BALB C, Graft Survival, nephrology, basic (laboratory) research, kidney transplantation, Delayed Graft Function, Original Articles, Recombinant Proteins, Mice, Inbred C57BL, Mice, Basic Science, Lipocalin-2, Acute Disease, Models, Animal, Animals, Transplantation, Homologous, Original Article, Female, science, Immunosuppressive Agents
Abstract

Lipocalin 2 (Lcn2) is rapidly produced by damaged nephron epithelia and is one of the most promising new markers of renal injury, delayed graft function and acute allograft rejection (AR); however, the functional importance of Lcn2 in renal transplantation is largely unknown. To understand the role of Lcn2 in renal AR, kidneys from Balb/c mice were transplanted into C57Bl/6 mice and vice versa and analyzed for morphological and physiological outcomes of AR at posttransplantation days 3, 5, and 7. The allografts showed a steady increase in intensity of interstitial infiltration, tubulitis and periarterial aggregation of lymphocytes associated with a substantial elevation in serum levels of creatinine, urea and Lcn2. Perioperative administration of recombinant Lcn2:siderophore:Fe complex (rLcn2) to recipients resulted in functional and morphological amelioration of the allograft at day 7 almost as efficiently as daily immunosuppression with cyclosporine A (CsA). No significant differences were observed in various donor–recipient combinations (C57Bl/6 wild‐type and Lcn2−/−, Balb/c donors and recipients). Histochemical analyses of the allografts showed reduced cell death in recipients treated with rLcn2 or CsA. These results demonstrate that Lcn2 plays an important role in reducing the extent of kidney AR and indicate the therapeutic potential of Lcn2 in transplantation., The authors demonstrate the function of lipocalin 2 as an upregulated marker during acute rejection and as a therapeutic agent to reduce acute rejection in a murine kidney transplantation model, supporting a possible future application of lipocalin 2 as an early biomarker as well as an immunosuppressive agent in kidney transplantation.

Published
2015

43. 125O First-in-human study of oral S 49076, a MET/AXL/FGFR inhibitor, in advanced solid tumors

Author

Postel-Vinay, S., primary, Hollebecque, A., additional, Soria, J.-C., additional, Balandraud, S., additional, Brendel, K., additional, Cattan, V., additional, Jacquet-Bescond, A., additional, Lopez Busto, N., additional, Malasse, S., additional, Marfai, L., additional, Pauly, J., additional, Prudkin, L., additional, Azaro, A., additional, and Rodon, J., additional

Published
2015
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48. Nucleation times in the 2D Ising model

Author

Brendel, K., Barkema, G.T., van Beijeren, H., Condensed Matter Theory, Statistical and Computational Physics, Universiteit Utrecht, and Dep Natuurkunde

Published
2005

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