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11 results on '"Brelsford, Jill"'

2. Correction: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Author

Diemert, David J., primary, Freire, Janaína, additional, Valente, Vanderson, additional, Fraga, Carlo Geraldo, additional, Talles, Frederico, additional, Grahek, Shannon, additional, Campbell, Doreen, additional, Jariwala, Amar, additional, Periago, Maria Victoria, additional, Enk, Martin, additional, Gazzinelli, Maria Flávia, additional, Bottazzi, Maria Elena, additional, Hamilton, Robert, additional, Brelsford, Jill, additional, Yakovleva, Anna, additional, Li, Guangzhao, additional, Peng, Jin, additional, Correa-Oliveira, Rodrigo, additional, Hotez, Peter, additional, and Bethony, Jeffrey, additional

Published
2020
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3. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development

Author

Diemert, David, primary, Campbell, Doreen, additional, Brelsford, Jill, additional, Leasure, Caitlyn, additional, Li, Guangzhao, additional, Peng, Jin, additional, Zumer, Maria, additional, Younes, Naji, additional, Bottazzi, Maria Elena, additional, Mejia, Rojelio, additional, Pritchard, David I, additional, Hawdon, John M, additional, and Bethony, Jeffrey M, additional

Published
2018
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4. Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

Author

Diemert, David J., primary, Freire, Janaína, additional, Valente, Vanderson, additional, Fraga, Carlos Geraldo, additional, Talles, Frederico, additional, Grahek, Shannon, additional, Campbell, Doreen, additional, Jariwala, Amar, additional, Periago, Maria Victoria, additional, Enk, Martin, additional, Gazzinelli, Maria Flávia, additional, Bottazzi, Maria Elena, additional, Hamilton, Robert, additional, Brelsford, Jill, additional, Yakovleva, Anna, additional, Li, Guangzhao, additional, Peng, Jin, additional, Correa-Oliveira, Rodrigo, additional, Hotez, Peter, additional, and Bethony, Jeffrey, additional

Published
2017
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5. Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine

Author

Brelsford, Jill B., primary, Plieskatt, Jordan L., additional, Yakovleva, Anna, additional, Jariwala, Amar, additional, Keegan, Brian P., additional, Peng, Jin, additional, Xia, Pengjun, additional, Li, Guangzhao, additional, Campbell, Doreen, additional, Periago, Maria Victoria, additional, Correa-Oliveira, Rodrigo, additional, Bottazzi, Maria Elena, additional, Hotez, Peter J., additional, Diemert, David, additional, and Bethony, Jeffrey M., additional

Published
2017
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7. Expression at a 20L scale and purification of the extracellular domain of theSchistosoma mansoniTSP-2 recombinant protein

Author

Curti, Elena, primary, Kwityn, Clifford, additional, Zhan, Bin, additional, Gillespie, Portia, additional, Brelsford, Jill, additional, Deumic, Vehid, additional, Plieskatt, Jordan, additional, Rezende, Wanderson C, additional, Tsao, Eric, additional, Kalampanayil, Bose, additional, Hotez, Peter J, additional, and Bottazzi, Maria Elena, additional

Published
2013
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8. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): A production process developed for a lead candidate recombinant hookworm vaccine antigen

Author

Goud, Gaddam Narsa, primary, Deumic, Vehid, additional, Gupta, Richi, additional, Brelsford, Jill, additional, Zhan, Bin, additional, Gillespie, Portia, additional, Plieskatt, Jordan L., additional, Tsao, Eric I., additional, Hotez, Peter J., additional, and Bottazzi, Maria Elena, additional

Published
2012
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9. Crystallization and preliminary X-ray analysis of Na-SAA-2 from the human hookworm parasiteNecator americanus

Author

Asojo, Oluwatoyin A., primary, Goud, Gaddam N., additional, Zhan, Bin, additional, Ordonez, Katherine, additional, Sedlacek, Meghan, additional, Homma, Kohei, additional, Deumic, Vehid, additional, Gupta, Richi, additional, Brelsford, Jill, additional, Price, Merelyn K., additional, Ngamelue, Michelle N., additional, and Hotez, Peter J., additional

Published
2010
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10. Crystallization and preliminary X-ray analysis of Na-SAA-2 from the human hookworm parasite Necator americanus.

Author

Asojo, Oluwatoyin A., Goud, Gaddam N., Zhan, Bin, Ordonez, Katherine, Sedlacek, Meghan, Homma, Kohei, Deumic, Vehid, Gupta, Richi, Brelsford, Jill, Price, Merelyn K., Ngamelue, Michelle N., and Hotez, Peter J.

Subjects
HOOKWORMS, HELMINTHS, NEMATODES, NECATOR americanus, SPACE groups
Abstract

Human hookworms are among the most pathogenic soil-transmitted helminths. These parasitic nematodes have co-evolved with the host and are able to maintain a high worm burden for decades without killing the human host. However, it is possible to develop vaccines against laboratory-challenge hookworm infections using either irradiated third-state infective larvae (L3) or enzymes from the adult parasites. In an effort to control hookworm infection globally, the Human Hookworm Vaccine Initiative, a product-development partnership with the Sabin Vaccine Institute to develop new control tools including vaccines, has identified a battery of protein antigens, including surface-associated antigens (SAAs) from L3. SAA proteins are characterized by a 13 kDa conserved domain of unknown function. SAA proteins are found on the surface of infective L3 stages (and some adult stages) of different nematode parasites, suggesting that they may play important roles in these organisms. The atomic structures and function of SAA proteins remain undetermined and in an effort to remedy this situation recombinant Na-SAA-2 from the most prevalent human hookworm parasite Necator americanus has been expressed, purified and crystallized. Useful X-ray data have been collected to 2.3 Å resolution from a crystal that belonged to the monoclinic space group C2 with unit-cell parameters a = 73.88, b = 35.58, c = 42.75 Å, β = 116.1°. [ABSTRACT FROM AUTHOR]

Published
2010
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11. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoniTSP-2 recombinant protein

Author

Curti, Elena, Kwityn, Clifford, Zhan, Bin, Gillespie, Portia, Brelsford, Jill, Deumic, Vehid, Plieskatt, Jordan, Rezende, Wanderson C, Tsao, Eric, Kalampanayil, Bose, Hotez, Peter J, and Bottazzi, Maria Elena

Abstract

A novel recombinant protein vaccine for human schistosomiasis caused by Schistosoma mansoniis under development. The Sm-TSP-2 schistosomiasis vaccine is comprised of a 9 kDa recombinant protein corresponding to the extracellular domain of a unique S. mansonitetraspanin. Here, we describe the cloning and the expression of the external loop of Sm-TSP-2 recombinant protein secreted by Pichia Pink™the process development at 20L scale fermentation, and the two-steps purification, which resulted in a protein recovery yield of 31% and a protein purity of 97%. The developed processes are suitable for the production of purified protein for subsequent formulation and Phase 1 clinical studies.

Published
2013
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