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3. AS PER PDF

Author

Schmitt, J., Haufe, E., Trautmann, F., Schulze, H.‐J., Elsner, P., Drexler, H., Bauer, A., Letzel, S., John, S.M., Fartasch, M., Brüning, T., Seidler, A., Dugas‐Breit, S., Gina, M., Weistenhöfer, W., Bachmann, K., Bruhn, I., Lang, B.M., Bonness, S., Allam, J.P., Grobe, W., Stange, T., Westerhausen, S., Knuschke, P., Wittlich, M., and Diepgen, T.L.

Published
2018
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4. Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population‐based case–control study FB‐181

Author

Schmitt, J., Haufe, E., Trautmann, F., Schulze, H.‐J., Elsner, P., Drexler, H., Bauer, A., Letzel, S., John, S.M., Fartasch, M., Brüning, T., Seidler, A., Dugas‐Breit, S., Gina, M., Weistenhöfer, W., Bachmann, K., Bruhn, I., Lang, B.M., Bonness, S., Allam, J.P., Grobe, W., Stange, T., Westerhausen, S., Knuschke, P., Wittlich, M., and Diepgen, T.L.

Published
2018
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15. Metalloenzymes

Author

Pollard, J. W., Danilkovitch-Miagkova, A., Minaguchi, T., Waite, K. A., Buys, T. P. H., Lam, W. L., Müller-Hermelink, H. K., Ott, G., Robb, V. A., Henske, E. P., Lynge, E., Boyd, N., Geisler, C., Seger, R., De Wolf-Peeters, C., Sagaert, X., Sheng, S., Ribatti, D., Verstovsek, S., Akin, C., Stack, M. S., Kitada, S., Gartenhaus, R., Moretti, F., Frühwald, Michael C., Mooi, W. J., Krausz, T., Kefford, R., Peikert, T., Specks, U., Tueting, T., Pföhler, C., Blask, D. E., Stevens, R. G., Nies, A. T., Gotoh, N., Tsuchida, N., Escriba, P., Singh, V., Hickey, M., Saunders, C., Xiao, G.-H., Testa, J. R., Furtwängler, R., Scholler, N., Carbone, M., Furge, K., Woude, G. F. V., Roland, W. C., Muschel, R., Hunter, K., Welch, D. R., Vaidya, K. S., Hurst, D. R., Silveira, A. C., Zang, X. A., Bari, R., Silveira, A., Szmulewitz, R., Taylor, J., Rinker-Schaffer, C., Shim, H., Plass, C., Lindsey, J. C., Clifford, S. C., Holdenrieder, S., Steinle, A., Salih, H., Brown, D. A., Breit, S. N., Bauskin, A. R., Mousses, S., Lung, M. L., Alix-Panabieres, C., Pantel, K., Djuzenova, C. S., Dalmay, T., Ahlquist, T., Lothe, R. A., Bhat, K., Setaluri, V., Rutka, J. T., Salhia, B., Cockell, K. A., Radich, J. P., Yamagishi, S.-I., Bignami, M., Verma, M., Kumar, D., Brenner, C., Zhang, Y.-W., Jamieson, D., Chi, Y.-H., Jeang, K.-T., Roninson, I., Dragani, T., Sobolev, A. S., Powers, M. V., Workmann, P., Evans, M. F., Cooper, K., Kausch, I., Doehn, C., Janz, S., Huang, C.-L., Toland, A. E., Osinaga, E., Kaye, F., Lemos, M. C., Thakker, R. V., Teh, B. T., Ponder, B. A. J., Mulligan, L. M., Gullo, C., Klein, G., Wu, X., Araten, D. J., Loeb, L. A., Cheadle, J. P., Lipsick, J., Albihn, A., Henriksson, M., Kremens, B., Germing, U., Zangemeister-Wittke, U., Simon, H.-U., Yu, Y. P., Luo, J., and Aman, P.

Published
2020

16. Metallothionein enzymes

Author

Pollard, J. W., Danilkovitch-Miagkova, A., Minaguchi, T., Waite, K. A., Buys, T. P. H., Lam, W. L., Müller-Hermelink, H. K., Ott, G., Robb, V. A., Henske, E. P., Lynge, E., Boyd, N., Geisler, C., Seger, R., De Wolf-Peeters, C., Sagaert, X., Sheng, S., Ribatti, D., Verstovsek, S., Akin, C., Stack, M. S., Kitada, S., Gartenhaus, R., Moretti, F., Frühwald, Michael C., Mooi, W. J., Krausz, T., Kefford, R., Peikert, T., Specks, U., Tueting, T., Pföhler, C., Blask, D. E., Stevens, R. G., Nies, A. T., Gotoh, N., Tsuchida, N., Escriba, P., Singh, V., Hickey, M., Saunders, C., Xiao, G.-H., Testa, J. R., Furtwängler, R., Scholler, N., Carbone, M., Furge, K., Woude, G. F. V., Roland, W. C., Muschel, R., Hunter, K., Welch, D. R., Vaidya, K. S., Hurst, D. R., Silveira, A. C., Zang, X. A., Bari, R., Silveira, A., Szmulewitz, R., Taylor, J., Rinker-Schaffer, C., Shim, H., Plass, C., Lindsey, J. C., Clifford, S. C., Holdenrieder, S., Steinle, A., Salih, H., Brown, D. A., Breit, S. N., Bauskin, A. R., Mousses, S., Lung, M. L., Alix-Panabieres, C., Pantel, K., Djuzenova, C. S., Dalmay, T., Ahlquist, T., Lothe, R. A., Bhat, K., Setaluri, V., Rutka, J. T., Salhia, B., Cockell, K. A., Radich, J. P., Yamagishi, S.-I., Bignami, M., Verma, M., Kumar, D., Brenner, C., Zhang, Y.-W., Jamieson, D., Chi, Y.-H., Jeang, K.-T., Roninson, I., Dragani, T., Sobolev, A. S., Powers, M. V., Workmann, P., Evans, M. F., Cooper, K., Kausch, I., Doehn, C., Janz, S., Huang, C.-L., Toland, A. E., Osinaga, E., Kaye, F., Lemos, M. C., Thakker, R. V., Teh, B. T., Ponder, B. A. J., Mulligan, L. M., Gullo, C., Klein, G., Wu, X., Araten, D. J., Loeb, L. A., Cheadle, J. P., Lipsick, J., Albihn, A., Henriksson, M., Kremens, B., Germing, U., Zangemeister-Wittke, U., Simon, H.-U., Yu, Y. P., Luo, J., and Aman, P.

Published
2020

17. Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study

Author

Bauer, A., Haufe, E., Heinrich, L., Seidler, A., Schulze, H. J., Elsner, P., Drexler, H., Letzel, S., John, S. M., Fartasch, M., Brüning, T., Dugas-Breit, S., Gina, M., Weistenhöfer, W., Bachmann, K., Bruhn, I., Lang, B. M., Brans, R., Allam, J. P., Grobe, W., Westerhausen, S., Knuschke, P., Wittlich, M., Diepgen, T. L., and Schmitt, J.

Subjects
ddc:610
Abstract

Background A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates. Objectives To evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure. Methods Six hundred forty-three participants suffering from incident basal cell carcinoma in commonly sun-exposed anatomic sites (capillitium, face, lip, neck, dorsum of the hands, forearms outside, décolleté) of a population-based, case-control, multicenter study performed from 2013 to 2015 in Germany were matched to controls without skin cancer. Multivariate logistic regression analysis was conducted stratified for histological subtype, phototype 1/2 and 3/4. Dose-response curves adjusted for age, age2, sex, phototype and non-occupational UV exposure were calculated. Results Participants with high versus no (OR 2.08; 95% CI 1.24–3.50; p = 0.006) or versus moderate (OR 2.05; 95% CI 1.15–3.65; p = 0.015) occupational UV exposure showed a more than two-fold significantly increased risk to develop BCC in commonly UV-exposed body sites. Multivariate regression analysis did not show an influence of phototype or histological subtype on risk estimates. The restriction of the analysis to BCC cases in commonly sun-exposed body sites did not influence the risk estimates. The occupational UV dosage leading to a 2-fold increased basal cell carcinoma risk was 6126 standard erythema doses. Conclusion The risk to develop basal cell carcinoma in highly occupationally UV-exposed skin was doubled consistently, independent of histological subtype, tumor localization and Fitzpatrick phototype.

Published
2020

36. Computing boundary forces due to unsteady, inviscid, incompressible flow

Author

Breit, S. R., Coney, W. C., and Webbs, J. R.

Subjects
Fluid dynamics -- Research, Vortex-motion -- Analysis, Aerospace and defense industries, Business
Abstract

Airfoil boundary forces caused by unsteady, incompressible, inviscid flow were studied using the simulation methods of artificial compressibility. Simulated convection of a compact vortex through a diverging/converging channel was generated through both the finite difference method (FDM) and discrete vortex method (DVM). The compact flows were then investigated by applying the different formulas for boundary forces. Results indicate that both DVM and FDM allow accurate solutions of the equations governing incompressible flow problems.

Published
1992

44. Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome

Author

Shnaper S., Desbaillets I., Brown D. A., Murat A., Migliavacca E., Schluep M., Ostermann S., Hamou M. F., Stupp R., Breit S. N., de Tribolet N., and Hegi M. E.

Abstract

For patients with brain tumors identification of diagnostic and prognostic markers in easy accessible biological material such as plasma or cerebrospinal fluid (CSF) would greatly facilitate patient management. MIC 1/GDF15 (growth differentiation factor 15) is a secreted protein of the TGF beta superfamily and emerged as a candidate marker exhibiting increasing mRNA expression during malignant progression of glioma. Determination of MIC 1/GDF15 protein levels by ELISA in the CSF of a cohort of 94 patients with intracranial tumors including gliomas meningioma and metastasis revealed significantly increased concentrations in glioblastoma patients (median 229 pg/ml) when compared with control cohort of patients treated for non neoplastic diseases (median below limit of detection of 156 pg/ml p < 0.0001 Mann Whitney test). However plasma MIC 1/GDF15 levels were not elevated in the matching plasma samples from these patients. Most interestingly patients with glioblastoma and increased CSF MIC 1/GDF15 had a shorter survival (p = 0.007 log rank test). In conclusion MIC 1/GDF15 protein measured in the CSF may have diagnostic and prognostic value in patients with intracranial tumors.

Published
2009
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47. Forschungsprojekt „Durch UVStrahlung induzierte bösartige Hauttumore“ – Berufliche und außerberufliche Exposition gegenüber UV-Strahlung und Hautkrebs

Author

Schmitt, J., primary, Haufe, E., additional, Trautmann, F., additional, Allam, J.P., additional, Bachmann, K., additional, Bauer, A., additional, Bieber, T., additional, Bonness, S., additional, Brans, R., additional, Brecht, B., additional, Brüning, T., additional, Bruhn, I., additional, Drexler, H., additional, Dugas-Breit, S., additional, Elsner, P., additional, Fartasch, M., additional, Gina, M., additional, Grabbe, S., additional, Grobe, W., additional, John, S.M., additional, Knuschke, P., additional, Küster, D., additional, Lang, B., additional, Letzel, S., additional, Ruppert, L., additional, Schulze, H.J., additional, Seidler, A., additional, Stange, T., additional, Stephan, V., additional, Thielitz, A., additional, Weistenhöfer, W., additional, Westerhausen, S., additional, Wittlich, M., additional, Zimmermann, E., additional, and Diepgen, T.L., additional

Published
2017
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50. The heart of psychotropic drug therapy

Author

Idle, Jeffrey R, Tie, H, Walker, B D, Valenzuela, S M, Breit, S N, and Campbell, T J

Subjects
Psychotropic drugs -- Adverse and side effects, Antidepressants, Tricyclic -- Physiological aspects
Published
2000

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