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The article is devoted to physical views on embryo development as a combination of structurally stable dynamics and symmetry-breaking events in the general process of self-organization. The first corresponds to the deterministic aspect of embryo development. The second type of processes is associated with sudden increase of variability in the periods of symmetry-breaking, which manifests unstable dynamics. The biological basis under these considerations includes chemokinetics (a system of inductors, repressors, and interaction with their next surrounding) and morphomechanics (i.e. mechanotransduction, mechanosensing, and related feedback loops). Although the latter research area is evolving rapidly, up to this time the role of mechanical properties of embryonic tissues and mechano-dependent processes in them are integrated in the general picture of embryo development to a lesser extent than biochemical signaling. For this reason, the present article is mostly devoted to experimental data on morphomechanics in the process of embryo development, also including analysis of its limitations and possible contradictions. The general system of feedback-loops and system dynamics delineated in this review is in large part a repetition of the views of Lev Beloussov, who was one of the founders of the whole areas of morphomechanics and morphodynamics, and to whose memory this article is dedicated., (Copyright © 2018. Published by Elsevier B.V.)

Trajectories of individual cell movements and patterns of differentiation in the axial rudiments in suprablastoporal areas (SBA) in whole embryos of Xenopus laevis artificially stretched in the transverse direction up to 120–200% from the initial length at the early gastrula stage were mapped. We observed the impairment of anisotropic cell movements of longitudinal stretching and latero-medial convergence inherent for SBA. Axial rudiments occurred in all cases, but their location was completely impaired and dramatically different from the normal topology for moderate (120–140%) stretching. Stronger stretching caused a partial ordering of the whole axial complex and its reorientation toward stretching. We concluded that induction factors determine short-range order in their arrangement in SBA, whereas anisotropic cell movements in any direction are needed for long-range order. Moderate transverse stretching destroys normally oriented anisotropy, but it is not enough for establishment of the anisotropy oriented perpendicular to the normal. This explains the disorder at light stretching. The main conclusion of this study is that anisotropic tensions of embryonic tissues play role of long-range order parameters of cell differentiation.