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Although breast tissue is in both sexes, it is more active and functional in women than in men. Breast tissue, which includes morphological and functional changes, including pre-puberty, reproductive and later periods, can be exposed to various diseases directly or indirectly related to all these changes. The human breast, especially in women, hosts a wide array of health conditions that range from simple to diagnose and treat, to diseases with high morbidity and mortality. Therefore, it also concerns multidisciplinary approaches that include different medical departments, not a single medical department. Considering all this, an updated approach to breast diseases will always be necessary. Within the scope of this book, an up to-date work will be created by treating breast tissue as anatomical, physiological and clinical by experts in the field.

Multidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. In a practical, easy-to-use format ideal for today's busy practitioners, this truly comprehensive resource is ideal for surgical oncologists, breast surgeons, general surgeons, medical oncologists, and others who need to stay informed of the latest innovations in this complex and fast-moving area. - Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, treatment for benign and malignant diseases of the breast. - Updates include an extensively updated oncoplastic section and extended medical and radiation oncology sections. - Delivers step-by-step clinical guidance highlighted by hundreds of superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. - Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, breast and plastic surgeons, radiation and medical oncologists, geneticists and other health care professionals who contribute to the management of patients with breast disease. - Includes access to procedural videos that provide expert visual guidance on how to execute key steps and techniques. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Written for all members of the multidisciplinary breast cancer care team, and for everyone who wishes to know about breast cancer, this concise resource will aid understanding of the risk of developing breast cancer, the essentials of diagnosis and preoperative assessment, and the current approach to treatment and follow-up, with a focus on how each mode of treatment can be optimized to match the individual patient's needs based on high-quality evidence. Table of Contents: • Etiopathophysiology and risk • Diagnosis • Staging and clinical status • Locoregional treatment • Adjuvant therapy • Survivorship

Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students.11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles.The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.

100 Questions & Answers About Metastatic Breast Cancer offers essential and practical guidance. This unique book provides both doctor and patient perspectives and offers answers to the most asked questions by patients and their loved ones. What is metastatic breast cancer? How will my oncologist decide how to treat my metastatic breast cancer? How is radiation used for treatment or control of metastatic breast cancer? Along with the answers to these and other questions, this book provides information on diagnosis, treatment, living with metastatic breast cancer, alternative medicine, targeted therapy, coping strategies, and more. Authored by Lillie Shockney, the foremost trusted expert on the topic, 100 Questions & Answers About Metastatic Breast Cancer is an invaluable resource for anyone coping with the physical and emotional uncertainty of this disease.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires. Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centersin India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy.Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.

'This honest and beautiful book is a story of resilience and doing life your way'Fearne Cotton'Kris's story should make you feel grateful for every second you're alive. It's a testament to her positivity, empathy, bravery and her unfailing sense of humour'Dermot O'Leary'A manifesto for how to be alive. It will leave you calm, hopeful and unafraid'Dawn O'Porter Kris was living a totally normal life as a twenty-three-year-old: travelling the world, falling in love, making plans. However, when she found a lump in her boob and was told that it was not only cancer, but also incurable, life took on a completely new meaning. She was diagnosed at an age when life wasn't something to be grateful for, but a goddamn right.Little did Kris know it was cancer that would lead her to a life she had never considered: a happy one. From founding a charity to visiting Downing Street, campaigning at festivals to appearing on TV, and being present at the birth of her nephew; in the face of all the possible prognoses, Kris thrived.Glittering a Turd is more than just another cancer memoir; it's a handbook for living life to the fullest, shining a new perspective on survival and learning to glitter your own turd, whatever it might be. Kris survived the unsurvivable for fifteen years. This is her story.

Das Mammakarzinom (Brustkrebs) ist ein bösartiger Tumor der Brustdrüse. Mit über 70.000 Diagnosen im Jahr ist das Mammakarzinom die häufigste Krebserkrankung der Frau. Allerdings können auch Männer an Brustkrebs erkranken, aus hundert Fällen ist im Durchschnitt ein Mann betroffen. Durch das hohe Aufkommen des Mammakarzinoms begegnet diese Erkrankung den Ärzten sehr häufig im Klinik- und Praxisalltag, weshalb die Entwicklung neuer, verbesserter Therapien für die Versorgung der Patienten überaus wichtig ist. Die Erkrankung ist durch ihre Vielseitigkeit eine große Herausforderung für die behandelnden Ärzte und fordert ein umfassendes Wissen über ihre Symptomatik, Diagnostik und Therapie. Das Manual bietet in seiner 18. Auflage einen Überblick über die aktuelle Behandlung der Mammakarzinome und führt neben den empfohlenen Standardtherapien auch die aktuellen klinischen Studienkonzepte auf. Gerade auf dem Gebiet der Mammakarzinome ist der Fortschritt bei Diagnostik und Therapie enorm. Grund hierfür sind unter anderem zahlreiche Studien, die national sowie auch international durchgeführt werden, um Brustkrebs erfolgreich zu bekämpfen. Die blauen Manuale, einschließlich das der Mammakarzinome, werden interdisziplinär erarbeitet und richten sich sowohl an den Allgemeinarzt als auch an die Ärzte der entsprechenden Fachrichtungen, im Rahmen dieses Manuals also überwiegend an Gynäkologen.

«Ambitious in its forms and disciplinary insights, this is health humanities writing of real value. An accessible, rich and real range of stories tells us what it is like to experience breast cancer. This book is for patients, clinicians and people who live close to this condition – and that really means all of us.» (Professor Jane Macnaughton, Institute for Medical Humanities, Durham University) «This is a wonderful collection of essays describing every aspect of breast cancer care, written by patients and the people who treat them. It is full of warmth, empathy and honesty, and will gently guide anyone through a diagnosis ofbreast cancer.» (Dr. Liz O'Riordan, author of The Complete Guide to Breast Cancer) This book offers a 360° look at breast cancer from individuals who have intimate understanding of and experience with it: patients who have lived or are living with the disease; healthcare providers whose perspectives patients and families rarely get to know; and researchers and scholars who examine breast cancer through various scientific and cultural lenses. Here you will meet 33 individuals from the UK and US who provide both factual information and personal insights in different forms: historical overview, personal essay, interview, play script, poem, interpersonal vignette, practical guidelines, comic, mixed-media photography exhibit and scholarly analysis. Breast cancer changes lives. This book is meant to be a single go-to source for people who want to understand more fully and clearly the lived experience of breast cancer – what those who know it best think and do and feel.

Prominent specialists champion the view that contemporary management of breast, or any, cancer requires the partnership of physicians, nurses, social workers, and all others whose special training and talents should be integrated for treating the whole patient. Here is the book that sets forth the rationale for this nationwide emerging concept and the means for accomplishing it.Dealing with total care of the whole patient, this new classic text is written by and for surgeons, radiation oncologists, medical oncologist, pathologists, radiologists, nurses, social workers, and others involved with the care and management of the patient with breast cancer.

For the past decade or so, research regarding women's health has become a major source of concern among health professionals. Due to the vast amounts of research, it has been difficult to amass a comprehensive source describing the challenges of physicians in this area of medical treatment and care. The Handbook of Research on Oncological and Endoscopical Dilemmas in Modern Gynecological Clinical Practice is a pivotal reference source that provides vital research on the application of clinical practices in regards to the health of women and prevention of severe, life-threatening diseases. While highlighting topics such as mental health, women's health, and preventative care, this publication provides an insight into critical dilemmas and issues in modern gynecologic oncology and endoscopy as well as the methods of daily clinical practice. This book is ideally designed for obstetricians, gynecologists, specialized physicians, medical professionals, academicians, researchers, and medical students.

This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.

Viele Werbeaktionen der „Mammografie-Screening-Industrie“ erwecken bei Frauen den Eindruck, dass Brustkrebs durch das Mammografie-Screening früher erkannt wird und dass dadurch die Lebensqualität verbessert und die Brustkrebs-Sterblichkeit verringert werden könne. Für diese Behauptung gibt es keine belastbaren Daten. Fakt ist: Im Screening werden vor allem die eher harmlosen Karzinome gefunden. Das Ergebnis: Frauen werden unnötig operiert, bestrahlt und chemotherapiert, obwohl sie in ihrem Leben niemals an Brustkrebs erkranken oder gar daran sterben würden. Fakt ist auch, dass bei einem Screening jeder dritte Brustkrebs nicht gefunden wird. Mit einem zusätzlichen Brust-Ultraschall würden viele dieser falsch-negativen Befunde entdeckt. Obwohl vom Gesetzgeber gefordert, werden Frauen vor dem Screening darüber nicht mündlich aufgeklärt. Etablierte Screening-Programme berücksichtigen nicht den Zuwachs des sich ständig weiterentwickelten Wissens. Ein zeitgemäßes und risikoadaptiertes Früherkennungs- und Vorsorgeprogramm braucht neue Strukturen. Die Früherkennung von Brustkrebs wird zukünftig nur noch Teil eines auf individuelle Risikoprofile abgestimmten integrativen Programms sein. Der Fokus wird auf Risiko-Management liegen.

Triple-negative breast cancer (TNBC) represents a challenge clinically due to the lack of actionable targets coupled with an aggressive disease course and a worse prognosis compared to other breast cancer subtypes. This book covers aspects of TNBC ranging from epidemiology, biology, molecular classification, to currently available and potentially new therapeutic options for TNBC. This book contains a range of recommended resources, including recent reviews, schematic illustrations, and information for patients with TNBC. Individuals including researchers and educators, practitioners, pharmaceutical professionals, patients as well as their family members will find this book useful.

This book is a practical guide to the management of patients with breast malignancies. It serves as a quick reference book that gives the most up-to-date routine practical management strategies of breast cancer. Written and edited by leading experts, this handbook focuses on the application of conventional and novel treatment strategies to the care of patients with malignant breast disease and all stages of breast cancer. The chapters provide evidence-based treatment strategies for all patient subsets. Surgical, radiation, and medical treatment options are all discussed for each stage of breast cancer. It also includes the definitions of statistical terminologies and their usage in clinical practice and research. This is a comprehensive yet concise resource for residents, fellows, and early-career practitioners.

Dear Reader, When I got my breast cancer diagnosis, I was immediately inundated with books on Cancer. They terrified me. So, this book…is Not Your Usual Boob. A little informative, a little sarcastic, a little funny—I hope—and a lot real. This is the book I wish I could have read in my time of need. A little bit of what you can expect during your journey, and how to prepare yourself with a healthy mindset and coping skills before they're needed. The #NoFilter is exactly that...no filter on the front cover—me and all my wonkiness with no photoshop—and it's what you'll find inside these pages—including an F-bomb or five. Because more important than shielding myself is being real with you. You may laugh, you may cry, you may want to punch me in the face...but in the end, remember this. If you ever meet me, I'm hugging you. Because that's me. And more than anything, that is the big reason behind this book. I am still ME. And YOU are still YOU. XO ~ MK Meredith

Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Expertsalso discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Christian theology at its core is a story about someone being in trouble. In response to this trouble, the triune God intervenes. God identifies with those in trouble, walking with them through the experience. Yet, the God of Christian theology goes a step further. God prevails over trouble. God is an overcomer. Black women with breast cancer identify with this God. They also see themselves in this theological narrative. They see themselves in the midst of troubles, troubles like racism, poverty and environmental exposures that create the disease affecting their bodies. They see the troubles of breast cancer, their biological disposition towards more aggressive cancers, later stage diagnoses, poorer prognoses, diminished quality of care and worse outcomes. Black women also palpably feel the troubles breast cancer brings like fear, physical disfigurement, social isolation, being stereotyped for treatment decisions, abandonment and even death. Black women feel the myriad troubles breast cancer brings. But, Black women also know God in their troubles. They know an active God who identifies with and prioritizes their needs. They know this God, through scripture and experience, as God who puts them front and center. And because they know God as an overcomer and creative force, they know themselves as overcomers. For with God, their troubles do not last always.Black women with breast cancer construct a cultural theology of breast cancer out of knowing God. Borne out of experiences of the Black Church, womanist theology and their intersectional identities of race, class and gender, this theological investigation, informed by anthropology, examines how Black women construct an ontology of who God is and how God operates and gain a God consciousness that shapes their response to the disease. Using pain, faith and testimony as tools to struggle against breast cancer Black survivors'theology transforms them from victims of breast cancer to change agents. Out of their lives as survivors comes a theology of complex hope- one cognizant of Black women's breast cancer disparities, yet oriented towards Black women's achievement of health in the present and the future– a sufficient hope to sustain Black women through it all.

« La Danse-Énergie-Thérapie » (DET), est une proposition thérapeutique de médiation artistique qui permet de lutter contre l'anxiété et les risques de dépression du fait qu'elle éveille en chaque être le désir de s'exprimer, de créer et de communiquer. Elle favorise la confiance en soi. Elle s'adresse ici spécifiquement aux femmes atteintes d'un cancer du sein, aux personnes en situation de handicap et aux enfants malades. Les personnes concernées par le soin (thérapeutes, aides-soignants, accompagnants) trouveront des outils artistiques thérapeutiques pour développer une bonne approche relationnelle avec des personnes en souffrance.

Das vorliegende Buch der Reihe WissenKompakt Medizin richtet sich an alle Patientinnen und deren Familien, die mit der Diagnose „Brustkrebs“ konfrontiert werden. Vom Umgang mit dem ersten Schock der Diagnose über operative, konservative und ergänzende Behandlungsmethoden klären Experten der Universitätsfrauenklinik Heidelberg auf. Ebenso sind medizinische Grundlagen und sozialrechtliche Aspekte verständlich und nachvollziehbar erläutert.Das Wissen um die Erkrankung ist der wichtigste Schritt in der Behandlung dieser! Betroffenen Frauen und ihren Familien soll dieses Buch Mut machen, mit der Erkrankung umzugehen und sie als Ratgeber im Alltag begleiten.

Although mammography is the primary method used for breast cancer screening, screening mammography is limited especially in women with dense breasts, which includes nearly 50% of all women in the United States. Despite improvements such as digital mammography, computed aided detection, and digital breast tomosynthesis, breast cancer continues to be a leading cause of cancer-related death in women. The recent proliferation of screening breast ultrasound has led to increased health care costs and false positives, with only a slight improvement in breast cancer detection. It is time for a better test.This is the first textbook dedicated to the subject of abbreviated breast MRI (AB-MR). The editors are principal investigators in the first multicenter trial evaluating AB-MR. Each chapter is authored by a leading expert in the field of breast MRI.AB-MR only takes 10 minutes or less to perform, has a comparable cost to screening breast ultrasound, and detects twice as many cancers compared to combined screening with mammography and ultrasound. The improved performance of AB-MR is irrespective of breast density, family history, overall breast cancer risk, and cancer characteristics (e.g. type, staging, invasive or intraductal, primary or recurrent). As such, it will likely become a routine screening tool in women with dense breasts.Key FeaturesA background on breast MR imaging including a review of current research dataFundamental guidelines for implementing, performing, and interpreting AB-MRTechnical approaches with proven efficacy, including biopsy methodsAccurate interpretation presented in an easy-to-read flow chart formatMore than 250 high quality color illustrationsAB-MR has the potential to help radiologists overcome breast cancer screening limitations and change current standards of practice. This book provides radiologists with the necessary tools to quickly incorporate AB-MR into clinical practice, with an ultimate goal of improved breast cancer detection rates and patient outcomes.

This book focuses on precursor lesions, borderline lesions, and early carcinomas of female-specific organs from the standpoint of pathology. In 2012, WHO Classification of Tumours of the Breast was revised and subsequently, in 2014, the WHO Classification of Tumours of Female Reproductive Organs was revised. In these latest versions, several new concepts are addressed that were not described in the previous editions, and many of them are related to the awareness of the specific pathogenesis of tumors in female patients. Although some of these issues are still controversial, several paradigm shifts should be understood by medical scientists. Thus researchers, diagnostic pathologists, and clinicians must share current information about what is taking place in the field and what the next issue to resolve is. This volume greatly broadens the reader's understanding of the new concepts and paradigm shifts, as it includes information on how to diagnose and makedifferential diagnoses on a practical basis and also provides a thorough explanation of the molecular–clinicopathologic basis of the new concepts. The book thus benefits gynecologists, breast surgeons, gynecologic–medical oncologists, and cytotechnologists.

Cancer is a frightening word, but within the last decade, more research has led to better detection and treatment of breast cancer. Since both men and women are at risk for developing breast cancer, it is important for all young adults to learn about practices such as self-exams that may lead to early detection. This information is presented along with full-color photographs and informative charts to help readers better understand this disease that affects so many people.

This book provides up-to-date information on all aspects of ductal carcinoma in situ of the breast, including epidemiology, imaging, pathologic and biologic features, interventional diagnostics, nonpalpable lesion localization, and treatment. Surgical procedures are described in detail, covering breast conservation techniques, conservative mastectomies, breast reconstruction options, and axillary surgery. Guidance is provided on how to ensure adequacy of surgical excision and avoid local recurrence when performing breast conservation surgery and how to minimize morbidity from axillary surgery. The role and techniques of partial and whole breast irradiation are described, and the use of adjuvant systemic therapy options, including endocrine therapy and chemotherapy, is explained. A concluding chapter addresses the issue of recurrence and its current management. This book, designed for ease of consultation, will be of value for all involved in the multidisciplinary care of patients withductal carcinoma in situ of the breast, including surgeons, medical oncologists, pathologists, radiologists, and radiotherapists.