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2. Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets

Author

Bouska, Alyssa, Bi, Chengfeng, Lone, Waseem, Zhang, Weiwei, Kedwaii, Ambreen, Heavican, Tayla, Lachel, Cynthia M., Yu, Jiayu, Ferro, Roberto, Eldorghamy, Nanees, Greiner, Timothy C., Vose, Julie, Weisenburger, Dennis D., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Jaffe, Elaine S., Braziel, Rita M., Siebert, Reiner, Miles, Rodney R., Dave, Sandeep, Reddy, Anupama, Delabie, Jan, Staudt, Louis M., Song, Joo Y., McKeithan, Timothy W., Fu, Kai, Green, Michael, Chan, Wing C., and Iqbal, Javeed

Published
2017
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3. Supplementary Fig. 3 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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4. Supplementary Fig. 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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5. Supplementary Table 2 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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6. Supplementary Fig. 5 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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7. Supplementary Fig. 4 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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8. Supplementary Table 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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9. Data from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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10. Supplementary Fig. 1 from Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

Author

Yang, Yibin, primary, Schmitz, Roland, primary, Mitala, Joseph, primary, Whiting, Amanda, primary, Xiao, Wenming, primary, Ceribelli, Michele, primary, Wright, George W., primary, Zhao, Hong, primary, Yang, Yandan, primary, Xu, Weihong, primary, Rosenwald, Andreas, primary, Ott, German, primary, Gascoyne, Randy D., primary, Connors, Joseph M., primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Delabie, Jan, primary, Smeland, Erlend B., primary, Braziel, Rita M., primary, Tubbs, Raymond R., primary, Cook, James R., primary, Weisenburger, Dennis D., primary, Chan, Wing C., primary, Wiestner, Adrian, primary, Kruhlak, Michael J., primary, Iwai, Kazuhiro, primary, Bernal, Federico, primary, and Staudt, Louis M., primary

Published
2023
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12. Data from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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13. CCR Translation for the Article from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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14. Supplementary Figure 1 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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15. CCR Translation for This Article from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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16. Supplementary Table 1 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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17. Supplementary Table 2 from A Comparative Analysis of Prognostic Factor Models for Follicular Lymphoma Based on a Phase III Trial of CHOP–Rituximab versus CHOP + 131Iodine—Tositumomab

Author

Press, Oliver W., primary, Unger, Joseph M., primary, Rimsza, Lisa M., primary, Friedberg, Jonathan W., primary, LeBlanc, Michael, primary, Czuczman, Myron S., primary, Kaminski, Mark, primary, Braziel, Rita M., primary, Spier, Catherine, primary, Gopal, Ajay K., primary, Maloney, David G., primary, Cheson, Bruce D., primary, Dakhil, Shaker R., primary, Miller, Thomas P., primary, and Fisher, Richard I., primary

Published
2023
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18. Supplementary Figure Legends 1-3, Tables 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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19. Supplementary Figures 1-3 from BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

Author

Iqbal, Javeed, primary, Meyer, Paul N., primary, Smith, Lynette M., primary, Johnson, Nathalie A., primary, Vose, Julie M., primary, Greiner, Timothy C., primary, Connors, Joseph M., primary, Staudt, Louis M., primary, Rimsza, Lisa, primary, Jaffe, Elaine, primary, Rosenwald, Andreas, primary, Ott, German, primary, Delabie, Jan, primary, Campo, Elias, primary, Braziel, Rita M., primary, Cook, James R., primary, Tubbs, Raymond R., primary, Gascoyne, Randy D., primary, Armitage, James O., primary, Weisenburger, Dennis D., primary, and Chan, Wing C., primary

Published
2023
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20. Supplementary Data from A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy

Author

Choi, William W.L., primary, Weisenburger, Dennis D., primary, Greiner, Timothy C., primary, Piris, Miguel A., primary, Banham, Alison H., primary, Delabie, Jan, primary, Braziel, Rita M., primary, Geng, Huimin, primary, Iqbal, Javeed, primary, Lenz, Georg, primary, Vose, Julie M., primary, Hans, Christine P., primary, Fu, Kai, primary, Smith, Lynette M., primary, Li, Min, primary, Liu, Zhongfeng, primary, Gascoyne, Randy D., primary, Rosenwald, Andreas, primary, Ott, German, primary, Rimsza, Lisa M., primary, Campo, Elias, primary, Jaffe, Elaine S., primary, Jaye, David L., primary, Staudt, Louis M., primary, and Chan, Wing C., primary

Published
2023
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21. Global microRNA expression profiling uncovers molecular markers for classification and prognosis in aggressive B-cell lymphoma

Author

Iqbal, Javeed, Shen, Yulei, Huang, Xin, Liu, Yanyan, Wake, Laura, Liu, Cuiling, Deffenbacher, Karen, Lachel, Cynthia M., Wang, Chao, Rohr, Joseph, Guo, Shuangping, Smith, Lynette M., Wright, George, Bhagavathi, Sharathkumar, Dybkaer, Karen, Fu, Kai, Greiner, Timothy C., Vose, Julie M., Jaffe, Elaine, Rimsza, Lisa, Rosenwald, Andreas, Ott, German, Delabie, Jan, Campo, Elias, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Armitage, James O., Weisenburger, Dennis D., Staudt, Louis M., Gascoyne, Randy D., McKeithan, Timothy W., and Chan, Wing C.

Published
2015
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22. BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma

Author

Kendrick, Samantha L., Redd, Lucas, Muranyi, Andrea, Henricksen, Leigh A., Stanislaw, Stacey, Smith, Lynette M., Perry, Anamarija M., Fu, Kai, Weisenburger, Dennis D., Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Jaffe, Elaine S., Campo, Elías, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Staudt, Louis M., Chan, Wing Chung, Steidl, Christian, Grogan, Thomas M., and Rimsza, Lisa M.

Published
2014
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23. Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Author

Iqbal, Javeed, Wright, George, Wang, Chao, Rosenwald, Andreas, Gascoyne, Randy D., Weisenburger, Dennis D., Greiner, Timothy C., Smith, Lynette, Guo, Shuangping, Wilcox, Ryan A., Teh, Bin Tean, Lim, Soon Thye, Tan, Soon Yong, Rimsza, Lisa M., Jaffe, Elaine S., Campo, Elias, Martinez, Antonio, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Ott, German, Geissinger, Eva, Gaulard, Philippe, Piccaluga, Pier Paolo, Pileri, Stefano A., Au, Wing Y., Nakamura, Shigeo, Seto, Masao, Berger, Francoise, de Leval, Laurence, Connors, Joseph M., Armitage, James, Vose, Julie, Chan, Wing C., and Staudt, Louis M.

Published
2014
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24. Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma

Author

Bouska, Alyssa, McKeithan, Timothy W., Deffenbacher, Karen E., Lachel, Cynthia, Wright, George W., Iqbal, Javeed, Smith, Lynette M., Zhang, Weiwei, Kucuk, Can, Rinaldi, Andrea, Bertoni, Francesco, Fitzgibbon, Jude, Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Dave, Bhavana J., Gascoyne, Randy D., Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Delabie, Jan, Jaffe, Elaine S., Braziel, Rita M., Connors, Joseph M., Staudt, Louis M., and Chan, Wing-Chung

Published
2014
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25. B-Cell Lymphomas

Author

Braziel, Rita M., Fan, Guang, Leonard, Debra G. B., editor, Bagg, Adam, editor, Caliendo, Angela M., editor, Kaul, Karen L., editor, and Van Deerlin, Vivianna M., editor

Published
2007
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27. A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma

Author

Perry, Anamarija M., Cardesa-Salzmann, Teresa M., Meyer, Paul N., Colomo, Luis, Smith, Lynette M., Fu, Kai, Greiner, Timothy C., Delabie, Jan, Gascoyne, Randy D., Rimsza, Lisa, Jaffe, Elaine S., Ott, German, Rosenwald, Andreas, Braziel, Rita M., Tubbs, Raymond, Cook, James R., Staudt, Louis M., Connors, Joseph M., Sehn, Laurie H., Vose, Julie M., López-Guillermo, Armando, Campo, Elias, Chan, Wing C., and Weisenburger, Dennis D.

Published
2012
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28. Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis

Author

Iqbal, Javeed, Shen, Yulei, Liu, Yanyan, Fu, Kai, Jaffe, Elaine S., Liu, Cuiling, Liu, Zhongfeng, Lachel, Cynthia M., Deffenbacher, Karen, Greiner, Timothy C., Vose, Julie M., Bhagavathi, Sharathkumar, Staudt, Louis M., Rimsza, Lisa, Rosenwald, Andreas, Ott, German, Delabie, Jan, Campo, Elias, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Gascoyne, Randy D., Armitage, James O., Weisenburger, Dennis D., McKeithan, Timothy W., and Chan, Wing C.

Published
2012
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29. Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Author

Muppidi, Jagan R., Schmitz, Roland, Green, Jesse A., Xiao, Wenming, Larsen, Adrien B., Braun, Sterling E., An, Jinping, Xu, Ying, Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Dennis D., Chan, Wing C., Vaidehi, Nagarajan, Staudt, Louis M., and Cyster, Jason G.

Subjects
Genetic research, Lymphomas -- Genetic aspects, B cells -- Physiological aspects, Cancer -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined (1,2). Work in mice showed that sphingosine-l-phosphate receptor-2 (S1PR2), a Gα12 and Gα13 coupled receptor, promotes growth regulation and local confinement of germinal centre B cells (3,4). Recent deep sequencing studies of GCB-DLBCL have revealed mutations in many genes in this cancer, including in GNA13 (encoding Gα13) and S1PR2 (refs 5-7). Here we show, using in vitro and in vivo assays, that GCBDLBCL-associated mutations occurring in S1PR2 frequently disrupt the receptor's Akt and migration inhibitory functions. Gα13-deficient mouse germinal centre B cells and human GCB-DLBCL cells were unable to suppress pAkt and migration in response to S1P, and Gα13-deficient mice developed germinal centre B-cell-derived lymphoma. Germinal centre B cells, unlike most lymphocytes, are tightly confined in lymphoid organs and do not recirculate. Remarkably, deficiency in Gα13, but not S1PR2, led to germinal centre B-cell dissemination into lymph and blood. GCB-DLBCL cell lines frequently carried mutations in the Gα13 effector ARHGEF1, and Arhgef1 deficiency also led to germinal centre B-cell dissemination. The incomplete phenocopy of Gα13- and S1PR2 deficiency led us to discover that P2RY8, an orphan receptor that is mutated in GCB-DLBCL and another germinal centre B-cell-derived malignancy, Burkitt's lymphoma, also represses germinal centre B-cell growth and promotes confinement via Gα13. These findings identify a Gα13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma., We sequenced the S1PR2 coding region in 117 GCB-DLBCL, 31 Burkitt's lymphoma and 68 activated B-cell-like (ABC)-DLBCL samples. Twelve S1PR2 coding mutations were identified in the GCB-DLBCL samples versus one [...]

Published
2014

30. Mutation and Genomic Deletion Status of ataxia telangiectasia mutated (ATM) and p53 Confer Specific Gene Expression Profiles in Mantle Cell Lymphoma

Author

Greiner, Timothy C., Dasgupta, Chiranjib, Ho, Vincent V., Weisenburger, Dennis D., Smith, Lynette M., Lynch, James C., Vose, Julie M., Fu, Kai, Armitage, James O., Braziel, Rita M., Campo, Elias, Delabie, Jan, Gascoyne, Randy D., Jaffe, Elaine S., Muller-Hermelink, Hans K., Ott, German, Rosenwald, Andreas, Staudt, Louis M., Im, Michael Y., Karaman, Mazen W., Pike, Brian L., Chan, Wing C., and Hacia, Joseph G.

Published
2006
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32. Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling

Author

Hartmann, Elena M., Campo, Elias, Wright, George, Lenz, Georg, Salaverria, Itziar, Jares, Pedro, Xiao, Wenming, Braziel, Rita M., Rimsza, Lisa M., Chan, Wing-Chung, Weisenburger, Dennis D., Delabie, Jan, Jaffe, Elaine S., Gascoyne, Randy D., Dave, Sandeep S., Mueller-Hermelink, Hans-Konrad, Staudt, Louis M., Ott, German, Beà, Sílvia, and Rosenwald, Andreas

Published
2010
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33. Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations

Author

Leich, Ellen, Salaverria, Itziar, Bea, Silvia, Zettl, Andreas, Wright, George, Moreno, Victor, Gascoyne, Randy D., Chan, Wing-Chung, Braziel, Rita M., Rimsza, Lisa M., Weisenburger, Dennis D., Delabie, Jan, Jaffe, Elaine S., Lister, Andrew, Fitzgibbon, Jude, Staudt, Louis M., Hartmann, Elena M., Mueller-Hermelink, Hans-Konrad, Campo, Elias, Ott, German, and Rosenwald, Andreas

Published
2009
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35. MAPK and JAK-STAT pathways dysregulation in plasmablastic lymphoma

Author

Ramis-Zaldivar, Joan Enric, primary, Gonzalez-Farre, Blanca, additional, Nicolae, Alina, additional, Pack, Svetlana, additional, Clot, Guillem, additional, Nadeu, Ferran, additional, Mottok, Anja, additional, Horn, Heike, additional, Song, Joo Y, additional, Fu, Kai, additional, Wright, George, additional, Gascoyne, Randy D., additional, Chan, Wing C., additional, Scott, David W., additional, Feldman, Andrew L., additional, Valera, Alexandra, additional, Enjuanes, Anna, additional, Braziel, Rita M., additional, Smeland, Erlend B., additional, Staudt, Louis M., additional, Rosenwald, Andreas, additional, Rimsza, Lisa M., additional, Ott, German, additional, Jaffe, Elaine S, additional, Salaverria, Itziar, additional, and Campo, Elias, additional

Published
2021
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37. Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study

Author

Young, Ken H., Leroy, Karen, Møller, Michael B., Colleoni, Gisele W.B., Sánchez-Beato, Margarita, Kerbauy, Fábio R., Haioun, Corinne, Eickhoff, Jens C., Young, Allen H., Gaulard, Philippe, Piris, Miguel A., Oberley, Terry D., Rehrauer, William M., Kahl, Brad S., Malter, James S., Campo, Elias, Delabie, Jan, Gascoyne, Randy D., Rosenwald, Andreas, Rimsza, Lisa, Huang, James, Braziel, Rita M., Jaffe, Elaine S., Wilson, Wyndham H., Staudt, Louis M., Vose, Julie M., Chan, Wing C., Weisenburger, Dennis D., and Greiner, Timothy C.

Published
2008
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38. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma

Author

Steidl, Christian, Tang Lee, Shah, Sohrab P., Farinha, Pedro, Guangming Han, Nayar, Tarun, Jones, Steven J., Iqbal, Javed, Weisenburger, Dennis D., Delaney, Allen, Bast, Martin A., Muller-Hermelink, Hans-Konrad, Rimsza, Lisa M., Campo, Elias, Rosenwald, Andreas, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Ray R., Jaffe, Elaine S., Lenz, Georg, Staudt, Louis M., Wing C. Chan, Gascoyre, Randy D., and Connors, Joseph M.

Subjects
Hodgkin's disease -- Care and treatment, Hodgkin's disease -- Patient outcomes, Hodgkin's disease -- Prognosis
Abstract

A study was conducted to evaluate the efficacy of correlating cellular signatures with treatment outcome in the cases of patients with classic Hodgkin's lymphoma. Results indicated that an increased number of tumor-associated macrophages were related to a shortened survival rate in the case of such patients, thereby showing a new biomarker.

Published
2010

39. Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features

Author

Enjuanes, Anna, Albero, Robert, Clot, Guillem, Navarro, Alba, Beà, Sílvia, Pinyol, Magda, Martín-Subero, José I., Klapper, Wolfram, Staudt, Louis M., Jaffe, Elaine S., Rimsza, Lisa, Braziel, Rita M., Delabie, Jan, Cook, James R., Tubbs, Raymond R., Gascoyne, Randy, Connors, Joseph M., Weisenburger, Dennis D., Greiner, Timothy C., Chan, Wing-Chung, López-Guillermo, Armando, Rosenwald, Andreas, Ott, German, Campo, Elías, and Jares, Pedro

Published
2013
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40. Expression of vascular endothelial growth factor and its receptors in rosacea

Author

Smith, Justine R., Lanier, Virginia B., Braziel, Rita M., Falkenhagen, Katherine M., White, Clifton, and Rosenbaum, James T.

Subjects
Vascular endothelial growth factor -- Analysis, Acne rosacea -- Development and progression, Acne rosacea -- Genetic aspects, Acne rosacea -- Research, Health
Published
2007

41. Molecular diagnosis of Burkitt's lymphoma

Author

Dave, Sandeep; Kai Fu, Wright, George W., Kluin, Philip, Lam, Lloyd T., Boerma, Evert-Jan, Greiner, Timothy C.; Weisenburger, Dennis D.; Rosenwald, Andreas; Ott, German, Rimsza, Lisa M.; Braziel, Rita M., Delabie, Jan, Muller-Hermelink, Hans-Konrad, Gascoyne, Randy D., Grogan, Thomas M., Campo, Elias; Jaffe, Elaine S.; Dave, Bhavana J.; Sanger, Warren; Bast, Martin; Vose, Julie M., Armitage, James O.; Connors, Joseph M.; Smeland, Erlend B.; Kvaloy, Stein; Holte, Harald; Fisher, Richard I., and Miller, Thomas P.; Montserrat, Emilio; Wyndham, Wilson H.; Bahl, Manisha; Hong Zhao; Liming Yang; Powell, John; Simon, Richard; Wing C. Chan; Staudt, Louis M.

Subjects
Burkitt's lymphoma -- Genetic aspects, Burkitt's lymphoma -- Diagnosis, Gene expression -- Research
Abstract

A study examines whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma. Results reveal that the molecular classifier of Burkitt's lymphoma based on gene-expression profiling provides a quantitative and reproducible diagnosis that is superior to other diagnostic methods.

Published
2006

42. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells

Author

Dave, Sandeep S., Chan, Wing C., Miller, Thomas P., Vose, Julie, Delabie, Jan, Davies, Andrew J., Montserrat, Emilio, Powell, John, Wright, George, Fisher, Richard I., LeBlanc, Michael, Armitage, James O., Connors, Joseph M., Norton, Andrew J., Wilson, Wyndham H., Hong Zhao, Tan, Bruce., Braziel, Rita M., Greiner, Timothy C., Smeland, Erlend B., Lansdorp, Peter M., Muller-Hermelink, H. Konrad, Jaffe, Elaine S., Goldschmidt, Neta, Rosenwald, Andreas, Rimsza, Lisa M., Weisenburger, Dennis D., Kvaloy, Stein, Qin Ouyang, Ott, German, Simon, Richard, French biblical critic, Chiorazzi, Michael, Gascoyne, Randy D., Grogan, Thomas M., Lynch, James C., Holte, Harald, Lister, T. Andrew, Campo, Elias, Liming Yang, and Staudt, Louis M.

Subjects
Patients -- Research, Lymphomas -- Diagnosis, Lymphomas -- Patient outcomes
Abstract

The patients with follicular lymphoma survival are determined to be for periods less than 1 year to more than 20 years after diagnosis. The gene-expression profiles of tumor-biopsy specimens obtained at diagnosis are used to develop a molecular predictor of the length of survival. It is found that the length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis.

Published
2004

43. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

Author

Schmitz, Roland, Young, Ryan M., Ceribelli, Michele, Jhavar, Sameer, Xiao, Wenming, Zhang, Meili, Wright, George, Shaffer, Arthur L., Hodson, Daniel J., Buras, Eric, Liu, Xuelu, Powell, John, Yang, Yandan, Xu, Weihong, Zhao, Hong, Kohlhammer, Holger, Rosenwald, Andreas, Kluin, Philip, Müller-Hermelink, Hans Konrad, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Ogwang, Martin D., Reynolds, Steven J., Fisher, Richard I., Braziel, Rita M., Tubbs, Raymond R., Cook, James R., Weisenburger, Dennis D., Chan, Wing C., Pittaluga, Stefania, Wilson, Wyndham, Waldmann, Thomas A., Rowe, Martin, Mbulaiteye, Sam M., Rickinson, Alan B., and Staudt, Louis M.

Published
2012
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44. Loss of major histocompatibility class II expression in non-immune-privileged site diffuse large B-cell lymphoma is highly coordinated and not due to chromosomal deletions

Author

Rimsza, Lisa M., Roberts, Robin A., Campo, Elias, Grogan, Thomas M., Bea, Silvia, Salaverria, Itziar, Zettl, Andreas, Rosenwald, Andreas, Ott, German, Muller-Hermelink, H. Konrad, Delabie, Jan, Fisher, Richard I., Unger, Joseph M., LeBlanc, Michael, Staudt, Louis M., Jaffe, Elaine S., Gascoyne, Randy D., Chan, Wing C., Weisenburger, Dennis D., Greiner, Timothy, Braziel, Rita M., and Miller, Thomas P.

Published
2006
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47. Oncogenically active MYD88 mutations in human lymphoma

Author

Ngo, Vu N., Young, Ryan M., Schmitz, Roland, Jhavar, Sameer, Xiao, Wenming, Lim, Kian-Huat, Kohlhammer, Holger, Xu, Weihong, Yang, Yandan, Zhao, Hong, Shaffer, Arthur L., Romesser, Paul, Wright, George, Powell, John, Rosenwald, Andreas, Muller-Hermelink, Hans Konrad, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Fisher, Richard I., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Denny D., Chan, Wing C., and Staudt, Louis M.

Published
2011
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49. Intraclonal Heterogeneity Caused By Activation-Induced Cytidine Deaminase Is Not a Prognostic Biomarker in Untreated Advanced Stage Follicular Lymphoma: An Analysis of SWOG S0016

Author

Burack, Richard, primary, Li, Hongli, additional, Adlowitz, Diana G, additional, Spence, Janice M, additional, Leblanc, Michael L., additional, Rimsza, Lisa M., additional, Braziel, Rita M., additional, Spier, Catherine M., additional, Kaminski, Mark S, additional, Leonard, John P., additional, Fisher, Richard I., additional, Smith, Sonali M., additional, and Friedberg, Jonathan W., additional

Published
2019
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50. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Author

Davis, Eric R., Ngo, Vu N., Lenz, Georg, Tolar, Pavel, Young, Ryan M., Romesser, Paul B., Kohlhammer, Holger, Lamy, Laurence, Zhao, Hong, Yang, Yandan, Xu, Weihong, Shaffer, Arthur L., Wright, George, Xiao, Wenming, Powell, John, Jiang, Jian-kang, Thomas, Craig J., Rosenwald, Andreas, Ott, German, Muller-Hermelink, Hans Konrad, Gascoyne, Randy D., Connors, Joseph M., Johnson, Nathalie A., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Wilson, Wyndham H., Delabie, Jan, Smeland, Erlend B., Fisher, Richard I., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Dennis D., Chan, Wing C., Pierce, Susan K., and Staudt, Louis M.

Published
2010
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