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2. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Steinmetz, J, Seeher, K, Schiess, N, Nichols, E, Cao, B, Servili, C, Cavallera, V, Cousin, E, Hagins, H, Moberg, M, Mehlman, M, Abate, Y, Abbas, J, Abbasi, M, Abbasian, M, Abbastabar, H, Abdelmasseh, M, Abdollahi, M, Abdollahifar, M, Abd-Rabu, R, Abdulah, D, Abdullahi, A, Abedi, A, Abedi, V, Abeldano Zuniga, R, Abidi, H, Abiodun, O, Aboagye, R, Abolhassani, H, Aboyans, V, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Aburuz, S, Adamu, L, Addo, I, Adebayo, O, Adekanmbi, V, Adekiya, T, Adikusuma, W, Adnani, Q, Adra, S, Afework, T, Afolabi, A, Afraz, A, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, S, Ahmadzade, A, Ahmed, A, Ahmed, H, Ahmed, J, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akade, S, Akbari, M, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemi, R, Akonde, M, Al Hasan, S, Alahdab, F, Al-Ahdal, T, Al-Amer, R, Albashtawy, M, Albataineh, M, Aldawsari, K, Alemi, H, Alemi, S, Algammal, A, Al-Gheethi, A, Alhalaiqa, F, Alhassan, R, Ali, A, Ali, E, Ali, L, Ali, M, Ali, R, Ali, S, Shujait Ali, S, Ali, Z, Alif, S, Alimohamadi, Y, Aliyi, A, Aljofan, M, Aljunid, S, Alladi, S, Almazan, J, Almustanyir, S, Al-Omari, B, Alqahtani, J, Alqasmi, I, Alqutaibi, A, Al-Shahi Salman, R, Altaany, Z, Al-Tawfiq, J, Altirkawi, K, Alvis-Guzman, N, Al-Worafi, Y, Aly, H, Aly, S, Alzoubi, K, Amani, R, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Amusa, G, Amzat, J, Ancuceanu, R, Anderlini, D, Anderson, D, Andrei, C, Androudi, S, Angappan, D, Angesom, T, Anil, A, Ansari-Moghaddam, A, Anwer, R, Arafat, M, Aravkin, A, Areda, D, Ariffin, H, Arifin, H, Arkew, M, Arnlov, J, Arooj, M, Artamonov, A, Artanti, K, Aruleba, R, Asadi-Pooya, A, Asena, T, Asghari-Jafarabadi, M, Ashraf, M, Ashraf, T, Atalell, K, Athari, S, Atinafu, B, Atorkey, P, Atout, M, Atreya, A, Aujayeb, A, Avan, A, Ayala Quintanilla, B, Ayatollahi, H, Ayinde, O, Mohammad Ayyoubzadeh, S, Azadnajafabad, S, Azizi, Z, Azizian, K, Azzam, A, Babaei, M, Badar, M, Badiye, A, Baghdadi, S, Bagherieh, S, Bai, R, Baig, A, Balakrishnan, S, Balalla, S, Baltatu, O, Banach, M, Bandyopadhyay, S, Banerjee, I, Baran, M, Barboza, M, Barchitta, M, Bardhan, M, Barker-Collo, S, Barnighausen, T, Barrow, A, Bashash, D, Bashiri, H, Bashiru, H, Basiru, A, Basso, J, Basu, S, Batiha, A, Batra, K, Baune, B, Bedi, N, Begde, A, Begum, T, Behnam, B, Behnoush, A, Beiranvand, M, Bejot, Y, Bekele, A, Belete, M, Belgaumi, U, Bemanalizadeh, M, Bender, R, Benfor, B, Bennett, D, Bensenor, I, Berice, B, Bettencourt, P, Beyene, K, Bhadra, A, Bhagat, D, Bhangdia, K, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, A, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, R, Bijani, A, Bikbov, B, Bilalaga, M, Biswas, A, Bitaraf, S, Bitra, V, Bjorge, T, Bodolica, V, Bodunrin, A, Boloor, A, Braithwaite, D, Brayne, C, Brenner, H, Briko, A, Bringas Vega, M, Brown, J, Budke, C, Buonsenso, D, Burkart, K, Burns, R, Bustanji, Y, Butt, M, Butt, N, Butt, Z, Cabral, L, dos Santos, F, Calina, D, Campos-Nonato, I, Cao, C, Carabin, H, Cardenas, R, Carreras, G, Carvalho, A, Castaneda-Orjuela, C, Casulli, A, Catala-Lopez, F, Catapano, A, Caye, A, Cegolon, L, Cenderadewi, M, Cerin, E, Chacon-Uscamaita, P, Chan, J, Chanie, G, Charan, J, Chattu, V, Chekol Abebe, E, Chen, H, Chen, J, Chi, G, Chichagi, F, Chidambaram, S, Chimoriya, R, Ching, P, Chitheer, A, Chong, Y, Chopra, H, Choudhari, S, Chowdhury, E, Chowdhury, R, Christensen, H, Chu, D, Chukwu, I, Chung, E, Coberly, K, Columbus, A, Comachio, J, Conde, J, Cortesi, P, Costa, V, Couto, R, Criqui, M, Cruz-Martins, N, Dabbagh Ohadi, M, Dadana, S, Dadras, O, Dai, X, Dai, Z, D'Amico, E, Danawi, H, Dandona, L, Dandona, R, Darwish, A, Das, S, Dascalu, A, Dash, N, Dashti, M, De la Hoz, F, de la Torre-Luque, A, De Leo, D, Dean, F, Dehghan, A, Dejene, H, Demant, D, Demetriades, A, Demissie, S, Deng, X, Desai, H, Devanbu, V, Dhama, K, Dharmaratne, S, Dhimal, M, Dias da Silva, D, Diaz, D, Dibas, M, Ding, D, Dinu, M, Dirac, M, Diress, M, Do, T, Doan, K, Dodangeh, M, Doheim, M, Dokova, K, Dongarwar, D, Dsouza, H, Dube, J, Duraisamy, S, Durojaiye, O, Dutta, S, Dziedzic, A, Edinur, H, Eissazade, N, Ekholuenetale, M, Ekundayo, T, El Nahas, N, El Sayed, I, Elahi Najafi, M, Elbarazi, I, Elemam, N, Elgar, F, Elgendy, I, Elhabashy, H, Elhadi, M, Elilo, L, Ellenbogen, R, Elmeligy, O, Elmonem, M, Elshaer, M, Elsohaby, I, Emamverdi, M, Emeto, T, Endres, M, Esezobor, C, Eskandarieh, S, Fadaei, A, Fagbamigbe, A, Fahim, A, Faramarzi, A, Fares, J, Farjoud Kouhanjani, M, Faro, A, Farzadfar, F, Fatehizadeh, A, Fathi, M, Fathi, S, Fatima, S, Feizkhah, A, Fereshtehnejad, S, Ferrari, A, Ferreira, N, Fetensa, G, Firouraghi, N, Fischer, F, Fonseca, A, Force, L, Fornari, A, Foroutan, B, Fukumoto, T, Gadanya, M, Gaidhane, A, Galali, Y, Galehdar, N, Gan, Q, Gandhi, A, Ganesan, B, Gardner, W, Garg, N, Gau, S, Gautam, R, Gebre, T, Gebrehiwot, M, Gebremeskel, G, Gebreslassie, H, Getacher, L, Ghaderi Yazdi, B, Ghadirian, F, Ghaffarpasand, F, Ghanbari, R, Ghasemi, M, Ghazy, R, Ghimire, S, Gholami, A, Gholamrezanezhad, A, Ghotbi, E, Ghozy, S, Gialluisi, A, Gill, P, Glasstetter, L, Gnedovskaya, E, Golchin, A, Golechha, M, Goleij, P, Golinelli, D, Gomes-Neto, M, Goulart, A, Goyal, A, Gray, R, Grivna, M, Guadie, H, Guan, B, Guarducci, G, Guicciardi, S, Gunawardane, D, Guo, H, Gupta, B, Gupta, R, Gupta, S, Gupta, V, Gutierrez, R, Habibzadeh, F, Hachinski, V, Haddadi, R, Hadei, M, Hadi, N, Haep, N, Haile, T, Haj-Mirzaian, A, Hall, B, Halwani, R, Hameed, S, Hamiduzzaman, M, Hammoud, A, Han, H, Hanifi, N, Hankey, G, Hannan, M, Hao, J, Harapan, H, Hareru, H, Hargono, A, Harlianto, N, Haro, J, Hartman, N, Hasaballah, A, Hasan, F, Hasani, H, Hasanian, M, Hassan, A, Hassan, S, Hassanipour, S, Hassankhani, H, Hassen, M, Haubold, J, Hay, S, Hayat, K, Hegazy, M, Heidari, G, Heidari, M, Heidari-Soureshjani, R, Hesami, H, Hezam, K, Hiraike, Y, Hoffman, H, Holla, R, Hopf, K, Horita, N, Hossain, M, Hossain, S, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, S, Hu, C, Huang, J, Huda, M, Hussain, J, Hussein, N, Huynh, H, Hwang, B, Ibitoye, S, Ilaghi, M, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Iravanpour, F, Islam, S, Ismail, F, Iso, H, Isola, G, Iwagami, M, Iwu, C, Iyer, M, Jaan, A, Jacob, L, Jadidi-Niaragh, F, Jafari, M, Jafarinia, M, Jafarzadeh, A, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jaiswal, A, Jakovljevic, M, Jamora, R, Jana, S, Javadi, N, Javed, S, Javeed, S, Jayapal, S, Jayaram, S, Jiang, H, Johnson, C, Johnson, W, Jokar, M, Jonas, J, Joseph, A, Joseph, N, Joshua, C, Jurisson, M, Kabir, A, Kabir, Z, Kabito, G, Kadashetti, V, Kafi, F, Kalani, R, Kalantar, F, Kaliyadan, F, Kamath, A, Kamath, S, Kanchan, T, Kandel, A, Kandel, H, Kanmodi, K, Karajizadeh, M, Karami, J, Karanth, S, Karaye, I, Karch, A, Karimi, A, Karimi, H, Karimi Behnagh, A, Kasraei, H, Kassebaum, N, Kauppila, J, Kaur, H, Kaur, N, Kayode, G, Kazemi, F, Keikavoosi-Arani, L, Keller, C, Keykhaei, M, Khadembashiri, M, Khader, Y, Khafaie, M, Khajuria, H, Khalaji, A, Khamesipour, F, Khammarnia, M, Khan, M, Khan, Y, Suheb, M, Khanmohammadi, S, Khanna, T, Khatab, K, Khatatbeh, H, Khatatbeh, M, Khateri, S, Khatib, M, Khayat Kashani, H, Khonji, M, Khorashadizadeh, F, Khormali, M, Khubchandani, J, Kian, S, Kim, G, Kim, J, Kim, M, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kivimaki, M, Kochhar, S, Kolahi, A, Koly, K, Kompani, F, Koroshetz, W, Kosen, S, Kourosh Arami, M, Koyanagi, A, Kravchenko, M, Krishan, K, Krishnamoorthy, V, Defo, B, Kuddus, M, Kumar, A, Kumar, G, Kumar, M, Kumar, N, Kumsa, N, Kundu, S, Kurniasari, M, Kusuma, D, Kuttikkattu, A, Kyu, H, La Vecchia, C, Ladan, M, Lahariya, C, Laksono, T, Lal, D, Lallukka, T, Lam, J, Lami, F, Landires, I, Langguth, B, Lasrado, S, Latief, K, Latifinaibin, K, Lau, K, Laurens, M, Lawal, B, Le, L, Le, T, Ledda, C, Lee, M, Lee, S, Lee, W, Lee, Y, Leonardi, M, Lerango, T, Li, M, Li, W, Ligade, V, Lim, S, Linehan, C, Liu, C, Liu, J, Liu, W, Lo, C, Lo, W, Lobo, S, Logroscino, G, Lopes, G, Lopukhov, P, Lorenzovici, L, Lorkowski, S, Loureiro, J, Lubinda, J, Lucchetti, G, Saute, R, Ma, Z, Mabrok, M, Machoy, M, Madadizadeh, F, El Razek, M, Maghazachi, A, Maghbouli, N, Mahjoub, S, Mahmoudi, M, Majeed, A, Malagon-Rojas, J, Malakan Rad, E, Malhotra, K, Malik, A, Malik, I, Mallhi, T, Malta, D, Manilal, A, Mansouri, V, Mansournia, M, Marasini, B, Marateb, H, Maroufi, S, Martinez-Raga, J, Martini, S, Martins-Melo, F, Martorell, M, Marz, W, Marzo, R, Massano, J, Mathangasinghe, Y, Mathews, E, Maude, R, Maugeri, A, Maulik, P, Mayeli, M, Mazaheri, M, Mcalinden, C, Mcgrath, J, Meena, J, Mehndiratta, M, Mendez-Lopez, M, Mendoza, W, Mendoza-Cano, O, Menezes, R, Merati, M, Meretoja, A, Merkin, A, Mersha, A, Mestrovic, T, Mi, T, Miazgowski, T, Michalek, I, Mihretie, E, Minh, L, Mirfakhraie, R, Mirica, A, Mirrakhimov, E, Mirzaei, M, Misganaw, A, Misra, S, Mithra, P, Mizana, B, Mohamadkhani, A, Mohamed, N, Mohammadi, E, Mohammadi, H, Mohammadi, S, Mohammadshahi, M, Mohammed, M, Mohammed, S, Mohan, S, Mojiri-Forushani, H, Moka, N, Mokdad, A, Molinaro, S, Moller, H, Monasta, L, Moniruzzaman, M, Montazeri, F, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moraga, P, Morovatdar, N, Morrison, S, Mosapour, A, Mosser, J, Mossialos, E, Motaghinejad, M, Mousavi, P, Ehsan Mousavi, S, Mubarik, S, Muccioli, L, Mughal, F, Mukoro, G, Mulita, A, Mulita, F, Musaigwa, F, Mustafa, A, Mustafa, G, Muthu, S, Nagarajan, A, Naghavi, P, Naik, G, Nainu, F, Nair, T, Najmuldeen, H, Nakhostin Ansari, N, Nambi, G, Namdar Areshtanab, H, Nargus, S, Nascimento, B, Naser, A, Nashwan, A, Nasoori, H, Nasreldein, A, Natto, Z, Nauman, J, Nayak, B, Nazri-Panjaki, A, Negaresh, M, Negash, H, Negoi, I, Negoi, R, Negru, S, Nejadghaderi, S, Nematollahi, M, Nesbit, O, Newton, C, Nguyen, D, Nguyen, H, Nguyen, N, Nguyen, P, Nguyen, V, Niazi, R, Nikolouzakis, T, Niranjan, V, Nnyanzi, L, Noman, E, Noroozi, N, Norrving, B, Noubiap, J, Nri-Ezedi, C, Ntaios, G, Nunez-Samudio, V, Nurrika, D, Oancea, B, Odetokun, I, O'Donnell, M, Ogunsakin, R, Oguta, J, Oh, I, Okati-Aliabad, H, Okeke, S, Okekunle, A, Okonji, O, Okwute, P, Olagunju, A, Olaiya, M, Olana, M, Olatubi, M, Oliveira, G, Olufadewa, I, Olusanya, B, Bali, A, Ong, S, Onwujekwe, O, Ordak, M, Orji, A, Ortega-Altamirano, D, Osuagwu, U, Otstavnov, N, Otstavnov, S, Ouyahia, A, Owolabi, M, Mahesh Padukudru, P, Pacheco-Barrios, K, Padubidri, J, Pal, P, Palange, P, Palladino, C, Palladino, R, Palma-Alvarez, R, Pan, F, Panagiotakos, D, Panda-Jonas, S, Pandey, A, Pandian, J, Pangaribuan, H, Pantazopoulos, I, Pardhan, S, Parija, P, Parikh, R, Park, S, Parthasarathi, A, Pashaei, A, Patel, J, Patil, S, Patoulias, D, Pawar, S, Pedersini, P, Pensato, U, Pereira, D, Pereira, J, Pereira, M, Peres, M, Perico, N, Perna, S, Petcu, I, Petermann-Rocha, F, Pham, H, Phillips, M, Pinilla-Monsalve, G, Piradov, M, Plotnikov, E, Poddighe, D, Polat, B, Poluru, R, Pond, C, Poudel, G, Pouramini, A, Pourbagher-Shahri, A, Pourfridoni, M, Pourtaheri, N, Prakash, P, Prakash, S, Prakash, V, Prates, E, Pritchett, N, Purnobasuki, H, Qasim, N, Qattea, I, Qian, G, Radhakrishnan, V, Raee, P, Shahraki, H, Rafique, I, Raggi, A, Raghav, P, Rahati, M, Rahim, F, Rahimi, Z, Rahimifard, M, Rahman, M, Rahmani, A, Rahmani, S, Youshanlouei, H, Rahmati, M, Raj Moolambally, S, Rajabpour-Sanati, A, Ramadan, H, Ramasamy, S, Ramasubramani, P, Ramazanu, S, Rancic, N, Rao, I, Rao, S, Rapaka, D, Rashedi, V, Rashid, A, Rashidi, M, Rashidi Alavijeh, M, Rasouli-Saravani, A, Rawaf, S, Razo, C, Redwan, E, Bana, A, Remuzzi, G, Rezaei, N, Rezaeian, M, Rhee, T, Riad, A, Robinson, S, Rodrigues, M, Rodriguez, J, Roever, L, Rogowski, E, Romoli, M, Ronfani, L, Roy, P, Pramanik, K, Rubagotti, E, Ruiz, M, Russ, T, Sunnerhagen, K, Saad, A, Saadatian, Z, Saber, K, Saberikamarposhti, M, Sacco, S, Saddik, B, Sadeghi, E, Sadeghian, S, Saeed, U, Safdarian, M, Safi, S, Sagar, R, Sagoe, D, Saheb Sharif-Askari, F, Saheb Sharif-Askari, N, Sahebkar, A, Sahoo, S, Sahraian, M, Sajedi, S, Sakshaug, J, Saleh, M, Salehi Omran, H, Salem, M, Salimi, S, Samadi Kafil, H, Samadzadeh, S, Samargandy, S, Samodra, Y, Samuel, V, Samy, A, Sanadgol, N, Sanjeev, R, Sanmarchi, F, Santomauro, D, Santri, I, Santric-Milicevic, M, Saravanan, A, Sarveazad, A, Satpathy, M, Saylan, M, Sayyah, M, Scarmeas, N, Schlaich, M, Schuermans, A, Schwarzinger, M, Schwebel, D, Selvaraj, S, Sendekie, A, Sengupta, P, Senthilkumaran, S, Serban, D, Sergindo, M, Sethi, Y, Seyedalinaghi, S, Seylani, A, Shabani, M, Shabany, M, Shafie, M, Shahabi, S, Shahbandi, A, Shahid, S, Shahraki-Sanavi, F, Shahsavari, H, Shahwan, M, Shaikh, M, Shaji, K, Sham, S, Shama, A, Shamim, M, Shams-Beyranvand, M, Shamsi, M, Shanawaz, M, Sharath, M, Sharfaei, S, Sharifan, A, Sharma, M, Sharma, R, Shashamo, B, Shayan, M, Sheikhi, R, Shekhar, S, Shen, J, Shenoy, S, Shetty, P, Shiferaw, D, Shigematsu, M, Shiri, R, Shittu, A, Shivakumar, K, Shokri, F, Shool, S, Shorofi, S, Shrestha, S, Siankam Tankwanchi, A, Siddig, E, Sigfusdottir, I, Silva, J, Silva, L, Sinaei, E, Singh, B, Singh, G, Singh, P, Singh, S, Sirota, S, Sivakumar, S, Sohag, A, Solanki, R, Soleimani, H, Solikhah, S, Solomon, Y, Song, S, Song, Y, Sotoudeh, H, Spartalis, M, Stark, B, Starnes, J, Starodubova, A, Stein, D, Steiner, T, Stovner, L, Suleman, M, Abdulkader, R, Sultana, A, Sun, J, Sunkersing, D, Sunny, A, Susianti, H, Swain, C, Szeto, M, Tabares-Seisdedos, R, Tabatabaei, S, Tabatabai, S, Tabish, M, Taheri, M, Tahvildari, A, Tajbakhsh, A, Tampa, M, Lukenze Tamuzi, J, Tan, K, Tang, H, Tareke, M, Tarigan, I, Tat, N, Tat, V, Tavakoli Oliaee, R, Tavangar, S, Tavasol, A, Tefera, Y, Tehrani-Banihashemi, A, Temesgen, W, Temsah, M, Teramoto, M, Tesfaye, A, Tesfaye, E, Tesler, R, Thakali, O, Thangaraju, P, Thapa, R, Thapar, R, Thomas, N, Thrift, A, Ticoalu, J, Tillawi, T, Toghroli, R, Tonelli, M, Tovani-Palone, M, Traini, E, Tran, N, Van Tran, P, Tromans, S, Truelsen, T, Truyen, T, Tsatsakis, A, Tsegay, G, Tsermpini, E, Tualeka, A, Tufa, D, Ubah, C, Udoakang, A, Ulhaq, I, Umair, M, Umakanthan, S, Umapathi, K, Unim, B, Unnikrishnan, B, Vaithinathan, A, Vakilian, A, Tahbaz, S, Valizadeh, R, Van den Eynde, J, Vart, P, Varthya, S, Vasankari, T, Vaziri, S, Vellingiri, B, Venketasubramanian, N, Verras, G, Vervoort, D, Villafane, J, Villani, L, Veloz, A, Viskadourou, M, Vladimirov, S, Vlassov, V, Volovat, S, Vu, L, Vujcic, I, Wagaye, B, Waheed, Y, Wahood, W, Walde, M, Wang, F, Wang, S, Wang, Y, Waqas, M, Waris, A, Weerakoon, K, Weintraub, R, Weldemariam, A, Westerman, R, Whisnant, J, Wickramasinghe, D, Wickramasinghe, N, Willekens, B, Wilner, L, Winkler, A, Wolfe, C, Wu, A, Wulf Hanson, S, Xu, S, Xu, X, Yadollahpour, A, Yaghoubi, S, Yahya, G, Yamagishi, K, Yang, L, Yano, Y, Yao, Y, Yehualashet, S, Yeshaneh, A, Yesiltepe, M, Yi, S, Yigit, A, Yigit, V, Yon, D, Yonemoto, N, You, Y, Younis, M, Yu, C, Yusuf, H, Zadey, S, Zahedi, M, Zakham, F, Zaki, N, Zali, A, Zamagni, G, Zand, R, Zandieh, G, Zangiabadian, M, Zarghami, A, Zastrozhin, M, Zeariya, M, Zegeye, Z, Zeukeng, F, 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D., Seeher K. M., Schiess N., Nichols E., Cao B., Servili C., Cavallera V., Cousin E., Hagins H., Moberg M. E., Mehlman M. L., Abate Y. H., Abbas J., Abbasi M. A., Abbasian M., Abbastabar H., Abdelmasseh M., Abdollahi M., Abdollahifar M. -A., Abd-Rabu R., Abdulah D. M., Abdullahi A., Abedi A., Abedi V., Abeldano Zuniga R. A., Abidi H., Abiodun O., Aboagye R. G., Abolhassani H., Aboyans V., Abrha W. A., Abualhasan A., Abu-Gharbieh E., Aburuz S., Adamu L. H., Addo I. Y., Adebayo O. M., Adekanmbi V., Adekiya T. A., Adikusuma W., Adnani Q. E. S., Adra S., Afework T., Afolabi A. A., Afraz A., Afzal S., Aghamiri S., Agodi A., Agyemang-Duah W., Ahinkorah B. O., Ahmad A., Ahmad D., Ahmad S., Ahmadzade A. M., Ahmed A., Ahmed H., Ahmed J. Q., Ahmed L. A., Ahmed M. B., Ahmed S. A., Ajami M., Aji B., Ajumobi O., Akade S., Akbari M., Akbarialiabad H., Akhlaghi S., Akinosoglou K., Akinyemi R. O., Akonde M., Al Hasan S. M., Alahdab F., Al-Ahdal T. M. A., Al-Amer R. M., Albashtawy M., AlBataineh M. 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N., Mirfakhraie R., Mirica A., Mirrakhimov E. M., Mirzaei M., Misganaw A., Misra S., Mithra P., Mizana B. A., Mohamadkhani A., Mohamed N. S., Mohammadi E., Mohammadi H., Mohammadi S., Mohammadshahi M., Mohammed M., Mohammed S., Mohan S., Mojiri-Forushani H., Moka N., Mokdad A. H., Molinaro S., Moller H., Monasta L., Moniruzzaman M., Montazeri F., Moradi M., Moradi Y., Moradi-Lakeh M., Moraga P., Morovatdar N., Morrison S. D., Mosapour A., Mosser J. F., Mossialos E., Motaghinejad M., Mousavi P., Ehsan Mousavi S., Mubarik S., Muccioli L., Mughal F., Mukoro G. D., Mulita A., Mulita F., Musaigwa F., Mustafa A., Mustafa G., Muthu S., Nagarajan A. J., Naghavi P., Naik G. R., Nainu F., Nair T. S., Najmuldeen H. H. R., Nakhostin Ansari N., Nambi G., Namdar Areshtanab H., Nargus S., Nascimento B. R., Naser A. Y., Nashwan A. J. J., Nasoori H., Nasreldein A., Natto Z. S., Nauman J., Nayak B. P., Nazri-Panjaki A., Negaresh M., Negash H., Negoi I., Negoi R. I., Negru S. M., Nejadghaderi S. A., Nematollahi M. H., Nesbit O. D., Newton C. R. J., Nguyen D. H., Nguyen H. T. H., Nguyen H. Q., Nguyen N. -T. T., Nguyen P. T., Nguyen V. T., Niazi R. K., Nikolouzakis T. K., Niranjan V., Nnyanzi L. A., Noman E. A., Noroozi N., Norrving B., Noubiap J. J., Nri-Ezedi C. A., Ntaios G., Nunez-Samudio V., Nurrika D., Oancea B., Odetokun I. A., O'Donnell M. J., Ogunsakin R. E., Oguta J. O., Oh I. -H., Okati-Aliabad H., Okeke S. R., Okekunle A. P., Okonji O. C., Okwute P. G., Olagunju A. T., Olaiya M. T., Olana M. D., Olatubi M. I., Oliveira G. M. M., Olufadewa I. I., Olusanya B. O., Bali A. O., Ong S., Onwujekwe O. E., Ordak M., Orji A. U., Ortega-Altamirano D. V., Osuagwu U. L., Otstavnov N., Otstavnov S. S., Ouyahia A., Owolabi M. O., Mahesh Padukudru P. A., Pacheco-Barrios K., Padubidri J. R., Pal P. K., Palange P. N., Palladino C., Palladino R., Palma-Alvarez R. F., Pan F., Panagiotakos D., Panda-Jonas S., Pandey A., Pandian J. D., Pangaribuan H. 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- Abstract
Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021. Methods: We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous s
- Published
- 2024
3. Erratum.
- Author
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Nelson, PT, Dickson, DW, Trojanowski, JQ, Jack, CR, Boyle, PA, Arfanakis, K, Rademakers, R, Alafuzoff, I, Attems, J, Brayne, C, Coyle-Gilchrist, ITS, Chui, HC, Fardo, DW, Flanagan, ME, Halliday, G, Hokkanen, SRK, Hunter, S, Jicha, GA, Katsumata, Y, Kawas, CH, Keene, CD, Kovacs, GG, Kukull, WA, Levey, AI, Makkinejad, N, Montine, TJ, Murayama, S, Murray, ME, Nag, S, Rissman, RA, Seeley, WW, Sperling, RA, White, CL, Yu, L, and Schneider, JA
- Subjects
Neurology & Neurosurgery ,Medical and Health Sciences ,Psychology and Cognitive Sciences - Abstract
The publisher apologizes for erroneously omitting part of the footnote for Table 2. This has now been corrected both online and in print.
- Published
- 2019
4. The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy — A Pooled Analysis of Two Randomized Controlled Trials
- Author
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den Brok, Melina G. H. E., Hoevenaar-Blom, M. P., Coley, N., Andrieu, S., van Dalen, J., Meiller, Y., Guillemont, J., Brayne, C., van Gool, W. A., Moll van Charante, E. P., and Richard, E.
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- 2022
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5. Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort
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Mistry, H, primary, Richardson, CD, additional, Higginbottom, A, additional, Ashford, Bridget, additional, Ahamed, Saif U, additional, Moore, Zoe, additional, Matthews, FE, additional, Brayne, C, additional, Simpson, JE, additional, and Wharton, SB, additional
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- 2024
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6. A novel Alzheimer disease locus located near the gene encoding tau protein.
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Jun, G, Ibrahim-Verbaas, CA, Vronskaya, M, Lambert, J-C, Chung, J, Naj, AC, Kunkle, BW, Wang, L-S, Bis, JC, Bellenguez, C, Harold, D, Lunetta, KL, Destefano, AL, Grenier-Boley, B, Sims, R, Beecham, GW, Smith, AV, Chouraki, V, Hamilton-Nelson, KL, Ikram, MA, Fievet, N, Denning, N, Martin, ER, Schmidt, H, Kamatani, Y, Dunstan, ML, Valladares, O, Laza, AR, Zelenika, D, Ramirez, A, Foroud, TM, Choi, S-H, Boland, A, Becker, T, Kukull, WA, van der Lee, SJ, Pasquier, F, Cruchaga, C, Beekly, D, Fitzpatrick, AL, Hanon, O, Gill, M, Barber, R, Gudnason, V, Campion, D, Love, S, Bennett, DA, Amin, N, Berr, C, Tsolaki, Magda, Buxbaum, JD, Lopez, OL, Deramecourt, V, Fox, NC, Cantwell, LB, Tárraga, L, Dufouil, C, Hardy, J, Crane, PK, Eiriksdottir, G, Hannequin, D, Clarke, R, Evans, D, Mosley, TH, Letenneur, L, Brayne, C, Maier, W, De Jager, P, Emilsson, V, Dartigues, J-F, Hampel, H, Kamboh, MI, de Bruijn, RFAG, Tzourio, C, Pastor, P, Larson, EB, Rotter, JI, O'Donovan, MC, Montine, TJ, Nalls, MA, Mead, S, Reiman, EM, Jonsson, PV, Holmes, C, St George-Hyslop, PH, Boada, M, Passmore, P, Wendland, JR, Schmidt, R, Morgan, K, Winslow, AR, Powell, JF, Carasquillo, M, Younkin, SG, Jakobsdóttir, J, Kauwe, JSK, Wilhelmsen, KC, Rujescu, D, Nöthen, MM, and Hofman, A
- Subjects
IGAP Consortium ,Chromosomes ,Human ,Pair 17 ,Humans ,Alzheimer Disease ,tau Proteins ,Polymorphism ,Single Nucleotide ,Apolipoprotein E4 ,Genome-Wide Association Study ,Alzheimer's Disease ,Prevention ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Human Genome ,Neurodegenerative ,Neurosciences ,Acquired Cognitive Impairment ,Genetics ,Brain Disorders ,Aging ,2.1 Biological and endogenous factors ,Neurological ,Psychiatry ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences - Abstract
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer's Project (IGAP) Consortium in APOE ɛ4+ (10 352 cases and 9207 controls) and APOE ɛ4- (7184 cases and 26 968 controls) subgroups as well as in the total sample testing for interaction between a single-nucleotide polymorphism (SNP) and APOE ɛ4 status. Suggestive associations (P
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- 2016
7. Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (Nature Communications, (2021), 12, 1, (3417), 10.1038/s41467-021-22491-8)
- Author
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de Rojas I., de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, I, Pedersen, N, Stringa, N, Zettergren, A, Hernandez, I, Montrreal, L, Antunez, C, Antonell, A, Tankard, R, Bis, J, Sims, R, Bellenguez, C, Quintela, I, Gonzalez-Perez, A, Calero, M, Franco-Macias, E, Macias, J, Blesa, R, Cervera-Carles, L, Menendez-Gonzalez, M, Frank-Garcia, A, Royo, J, Moreno, F, Huerto Vilas, R, Baquero, M, Diez-Fairen, M, Lage, C, Garcia-Madrona, S, Garcia-Gonzalez, P, Alarcon-Martin, E, Valero, S, Sotolongo-Grau, O, Ullgren, A, Naj, A, Lemstra, A, Benaque, A, Perez-Cordon, A, Benussi, A, Rabano, A, Padovani, A, Squassina, A, de Mendonca, A, Arias Pastor, A, Kok, A, Meggy, A, Pastor, A, Espinosa, A, Corma-Gomez, A, Martin Montes, A, Sanabria, A, Destefano, A, Schneider, A, Haapasalo, A, Kinhult Stahlbom, A, Tybjaerg-Hansen, A, Hartmann, A, Spottke, A, Corbaton-Anchuelo, A, Rongve, A, Borroni, B, Arosio, B, Nacmias, B, Nordestgaard, B, Kunkle, B, Charbonnier, C, Abdelnour, C, Masullo, C, Martinez Rodriguez, C, Munoz-Fernandez, C, Dufouil, C, Graff, C, Ferreira, C, Chillotti, C, Reynolds, C, Fenoglio, C, Van Broeckhoven, C, Clark, C, Pisanu, C, Satizabal, C, Holmes, C, Buiza-Rueda, D, Aarsland, D, Rujescu, D, Alcolea, D, Galimberti, D, Wallon, D, Seripa, D, Grunblatt, E, Dardiotis, E, Duzel, E, Scarpini, E, Conti, E, Rubino, E, Gelpi, E, Rodriguez-Rodriguez, E, Duron, E, Boerwinkle, E, Ferri, E, Tagliavini, F, Kucukali, F, Pasquier, F, Sanchez-Garcia, F, Mangialasche, F, Jessen, F, Nicolas, G, Selbaek, G, Ortega, G, Chene, G, Hadjigeorgiou, G, Rossi, G, Spalletta, G, Giaccone, G, Grande, G, Binetti, G, Papenberg, G, Hampel, H, Bailly, H, Zetterberg, H, Soininen, H, Karlsson, I, Alvarez, I, Appollonio, I, Giegling, I, Skoog, I, Saltvedt, I, Rainero, I, Rosas Allende, I, Hort, J, Diehl-Schmid, J, Van Dongen, J, Vidal, J, Lehtisalo, J, Wiltfang, J, Thomassen, J, Kornhuber, J, Haines, J, Vogelgsang, J, Pineda, J, Fortea, J, Popp, J, Deckert, J, Buerger, K, Morgan, K, Fliessbach, K, Sleegers, K, Molina-Porcel, L, Kilander, L, Weinhold, L, Farrer, L, Wang, L, Kleineidam, L, Farotti, L, Parnetti, L, Tremolizzo, L, Hausner, L, Benussi, L, Froelich, L, Ikram, M, Deniz-Naranjo, M, Tsolaki, M, Rosende-Roca, M, Lowenmark, M, Hulsman, M, Spallazzi, M, Pericak-Vance, M, Esiri, M, Bernal Sanchez-Arjona, M, Dalmasso, M, Martinez-Larrad, M, Arcaro, M, Nothen, M, Fernandez-Fuertes, M, Dichgans, M, Ingelsson, M, Herrmann, M, Scherer, M, Vyhnalek, M, Kosmidis, M, Yannakoulia, M, Schmid, M, Ewers, M, Heneka, M, Wagner, M, Scamosci, M, Kivipelto, M, Hiltunen, M, Zulaica, M, Alegret, M, Fornage, M, Roberto, N, van Schoor, N, Seidu, N, Banaj, N, Armstrong, N, Scarmeas, N, Scherbaum, N, Goldhardt, O, Hanon, O, Peters, O, Skrobot, O, Quenez, O, Lerch, O, Bossu, P, Caffarra, P, Dionigi Rossi, P, Sakka, P, Mecocci, P, Hoffmann, P, Holmans, P, Fischer, P, Riederer, P, Yang, Q, Marshall, R, Kalaria, R, Mayeux, R, Vandenberghe, R, Cecchetti, R, Ghidoni, R, Frikke-Schmidt, R, Sorbi, S, Hagg, S, Engelborghs, S, Helisalmi, S, Botne Sando, S, Kern, S, Archetti, S, Boschi, S, Fostinelli, S, Gil, S, Mendoza, S, Mead, S, Ciccone, S, Djurovic, S, Heilmann-Heimbach, S, Riedel-Heller, S, Kuulasmaa, T, del Ser, T, Lebouvier, T, Polak, T, Ngandu, T, Grimmer, T, Bessi, V, Escott-Price, V, Giedraitis, V, Deramecourt, V, Maier, W, Jian, X, Pijnenburg, Y, Smith, A, Saenz, A, Bizzarro, A, Lauria, A, Vacca, A, Solomon, A, Anastasiou, A, Richardson, A, Boland, A, Koivisto, A, Daniele, A, Greco, A, Marianthi, A, Mcguinness, B, Fin, B, Ferrari, C, Custodero, C, Ferrarese, C, Ingino, C, Mangone, C, Reyes Toso, C, Martinez, C, Cuesta, C, Muchnik, C, Joachim, C, Ortiz, C, Besse, C, Johansson, C, Zoia, C, Laske, C, Anastasiou, C, Palacio, D, Politis, D, Janowitz, D, Craig, D, Mann, D, Neary, D, Jurgen, D, Daian, D, Belezhanska, D, Kohler, E, Castano, E, Koutsouraki, E, Chipi, E, De Roeck, E, Costantini, E, Vardy, E, Piras, F, Roveta, F, Prestia, F, Assogna, F, Salani, F, Sala, G, Lacidogna, G, Novack, G, Wilcock, G, Thonberg, H, Kolsch, H, Weber, H, Boecker, H, Etchepareborda, I, Piaceri, I, Tuomilehto, J, Lindstrom, J, Laczo, J, Johnston, J, Deleuze, J, Harris, J, Schott, J, Priller, J, Bacha, J, Snowden, J, Lisso, J, Mihova, K, Traykov, L, Morelli, L, Brusco, L, Rainer, M, Takalo, M, Bjerke, M, Del Zompo, M, Serpente, M, Sanchez Abalos, M, Rios, M, Peltonen, M, Herrman, M, Kohler, M, Rojo, M, Jones, M, Orsini, M, Medel, N, Olivar, N, Fox, N, Salvadori, N, Hooper, N, Galeano, P, Solis, P, Bastiani, P, Passmore, P, Heun, R, Antikainen, R, Olaso, R, Perneczky, R, Germani, S, Lopez-Garcia, S, Love, S, Mehrabian, S, Bagnoli, S, Kochen, S, Andreoni, S, Teipel, S, Todd, S, Pickering-Brown, S, Natunen, T, Tegos, T, Laatikainen, T, Strandberg, T, Polvikoski, T, Matoska, V, Ciullo, V, Cores, V, Solfrizzi, V, Lisetti, V, Sevillano, Z, Aguilera, N, Alarcon, E, Boada, M, Buendia, M, Canabate, P, Carracedo, A, Diego, S, Gailhajenet, A, Guitart, M, Ibarria, M, Lafuente, A, Maronas, O, Martin, E, Martinez, M, Marquie, M, Mauleon, A, Moreno, M, Orellana, A, Pancho, A, Peleja, E, Preckler, S, Real, L, Ruiz, A, Saez, M, Serrano-Rios, M, Tarraga, L, Vargas, L, Adarmes-Gomez, A, Alonso, M, Alvarez, V, Amer-Ferrer, G, Antequera, M, Bernal, M, Bullido, M, Burguera, J, Carrillo, F, Carrion-Claro, M, Casajeros, M, Clarimon, J, Cruz-Gamero, J, de Pancorbo, M, Escuela, R, Garrote-Espina, L, Garcia-Alberca, J, Garcia Madrona, S, Garcia-Ribas, G, Gomez-Garre, P, Hevilla, S, Jesus, S, Labrador Espinosa, M, Legaz, A, Lleo, A, Lopez de Munain, A, Macias-Garcia, D, Manzanares, S, Marin, M, Marin-Munoz, J, Marin, T, Martinez, B, Martinez, V, Martinez-Lage Alvarez, P, Medina, M, Mendioroz Iriarte, M, Mir, P, Molinuevo, J, Pastor, P, Perez Tur, J, Perinan-Tocino, T, Pineda-Sanchez, R, Pinol-Ripoll, G, Real de Asua, D, Rodrigo, S, Sanchez del Valle Diaz, R, Sanchez-Juan, P, Sastre, I, Vicente, M, Vigo-Ortega, R, Vivancos, L, Macleod, C, Mccracken, C, Brayne, C, Bresner, C, Grozeva, D, Bellou, E, Sommerville, E, Matthews, F, Leonenko, G, Menzies, G, Windle, G, Harwood, J, Phillips, J, Bennett, K, Luckuck, L, Clare, L, Woods, R, Saad, S, Burholt, V, Kehoe, P, Scheltens, P, Holstege, H, Amouyel, P, Schellenberg, G, Williams, J, Seshadri, S, van Duijn, C, Mather, K, Sanchez-Valle, R, Blennow, K, Huisman, M, Andreassen, O, Posthuma, D, van der Flier, W, Ramirez, A, Lambert, J, van der Lee, S, de Rojas I., Moreno-Grau S., Tesi N., Grenier-Boley B., Andrade V., Jansen I. E., Pedersen N. L., Stringa N., Zettergren A., Hernandez I., Montrreal L., Antunez C., Antonell A., Tankard R. M., Bis J. C., Sims R., Bellenguez C., Quintela I., Gonzalez-Perez A., Calero M., Franco-Macias E., Macias J., Blesa R., Cervera-Carles L., Menendez-Gonzalez M., Frank-Garcia A., Royo J. L., Moreno F., Huerto Vilas R., Baquero M., Diez-Fairen M., Lage C., Garcia-Madrona S., Garcia-Gonzalez P., Alarcon-Martin E., Valero S., Sotolongo-Grau O., Ullgren A., Naj A. C., Lemstra A. W., Benaque A., Perez-Cordon A., Benussi A., Rabano A., Padovani A., Squassina A., de Mendonca A., Arias Pastor A., Kok A. A. L., Meggy A., Pastor A. B., Espinosa A., Corma-Gomez A., Martin Montes A., Sanabria A., DeStefano A. L., Schneider A., Haapasalo A., Kinhult Stahlbom A., Tybjaerg-Hansen A., Hartmann A. M., Spottke A., Corbaton-Anchuelo A., Rongve A., Borroni B., Arosio B., Nacmias B., Nordestgaard B. G., Kunkle B. W., Charbonnier C., Abdelnour C., Masullo C., Martinez Rodriguez C., Munoz-Fernandez C., Dufouil C., Graff C., Ferreira C. B., Chillotti C., Reynolds C. A., Fenoglio C., Van Broeckhoven C., Clark C., Pisanu C., Satizabal C. L., Holmes C., Buiza-Rueda D., Aarsland D., Rujescu D., Alcolea D., Galimberti D., Wallon D., Seripa D., Grunblatt E., Dardiotis E., Duzel E., Scarpini E., Conti E., Rubino E., Gelpi E., Rodriguez-Rodriguez E., Duron E., Boerwinkle E., Ferri E., Tagliavini F., Kucukali F., Pasquier F., Sanchez-Garcia F., Mangialasche F., Jessen F., Nicolas G., Selbaek G., Ortega G., Chene G., Hadjigeorgiou G., Rossi G., Spalletta G., Giaccone G., Grande G., Binetti G., Papenberg G., Hampel H., Bailly H., Zetterberg H., Soininen H., Karlsson I. K., Alvarez I., Appollonio I., Giegling I., Skoog I., Saltvedt I., Rainero I., Rosas Allende I., Hort J., Diehl-Schmid J., Van Dongen J., Vidal J. -S., Lehtisalo J., Wiltfang J., Thomassen J. Q., Kornhuber J., Haines J. L., Vogelgsang J., Pineda J. A., Fortea J., Popp J., Deckert J., Buerger K., Morgan K., Fliessbach K., Sleegers K., Molina-Porcel L., Kilander L., Weinhold L., Farrer L. A., Wang L. -S., Kleineidam L., Farotti L., Parnetti L., Tremolizzo L., Hausner L., Benussi L., Froelich L., Ikram M. A., Deniz-Naranjo M. C., Tsolaki M., Rosende-Roca M., Lowenmark M., Hulsman M., Spallazzi M., Pericak-Vance M. A., Esiri M., Bernal Sanchez-Arjona M., Dalmasso M. C., Martinez-Larrad M. T., Arcaro M., Nothen M. M., Fernandez-Fuertes M., Dichgans M., Ingelsson M., Herrmann M. J., Scherer M., Vyhnalek M., Kosmidis M. H., Yannakoulia M., Schmid M., Ewers M., Heneka M. T., Wagner M., Scamosci M., Kivipelto M., Hiltunen M., Zulaica M., Alegret M., Fornage M., Roberto N., van Schoor N. M., Seidu N. M., Banaj N., Armstrong N. J., Scarmeas N., Scherbaum N., Goldhardt O., Hanon O., Peters O., Skrobot O. A., Quenez O., Lerch O., Bossu P., Caffarra P., Dionigi Rossi P., Sakka P., Mecocci P., Hoffmann P., Holmans P. A., Fischer P., Riederer P., Yang Q., Marshall R., Kalaria R. N., Mayeux R., Vandenberghe R., Cecchetti R., Ghidoni R., Frikke-Schmidt R., Sorbi S., Hagg S., Engelborghs S., Helisalmi S., Botne Sando S., Kern S., Archetti S., Boschi S., Fostinelli S., Gil S., Mendoza S., Mead S., Ciccone S., Djurovic S., Heilmann-Heimbach S., Riedel-Heller S., Kuulasmaa T., del Ser T., Lebouvier T., Polak T., Ngandu T., Grimmer T., Bessi V., Escott-Price V., Giedraitis V., Deramecourt V., Maier W., Jian X., Pijnenburg Y. A. L., Smith A. D., Saenz A., Bizzarro A., Lauria A., Vacca A., Solomon A., Anastasiou A., Richardson A., Boland A., Koivisto A., Daniele A., Greco A., Marianthi A., McGuinness B., Fin B., Ferrari C., Custodero C., Ferrarese C., Ingino C., Mangone C., Reyes Toso C., Martinez C., Cuesta C., Muchnik C., Joachim C., Ortiz C., Besse C., Johansson C., Zoia C. P., Laske C., Anastasiou C., Palacio D. L., Politis D. G., Janowitz D., Craig D., Mann D. M., Neary D., Jurgen D., Daian D., Belezhanska D., Kohler E., Castano E. M., Koutsouraki E., Chipi E., De Roeck E., Costantini E., Vardy E. R. L. C., Piras F., Roveta F., Prestia F. A., Assogna F., Salani F., Sala G., Lacidogna G., Novack G., Wilcock G., Thonberg H., Kolsch H., Weber H., Boecker H., Etchepareborda I., Piaceri I., Tuomilehto J., Lindstrom J., Laczo J., Johnston J., Deleuze J. -F., Harris J., Schott J. M., Priller J., Bacha J. I., Snowden J., Lisso J., Mihova K. Y., Traykov L., Morelli L., Brusco L. I., Rainer M., Takalo M., Bjerke M., Del Zompo M., Serpente M., Sanchez Abalos M., Rios M., Peltonen M., Herrman M. J., Kohler M., Rojo M., Jones M., Orsini M., Medel N., Olivar N., Fox N. C., Salvadori N., Hooper N. M., Galeano P., Solis P., Bastiani P., Passmore P., Heun R., Antikainen R., Olaso R., Perneczky R., Germani S., Lopez-Garcia S., Love S., Mehrabian S., Bagnoli S., Kochen S., Andreoni S., Teipel S., Todd S., Pickering-Brown S., Natunen T., Tegos T., Laatikainen T., Strandberg T., Polvikoski T. M., Matoska V., Ciullo V., Cores V., Solfrizzi V., Lisetti V., Sevillano Z., Aguilera N., Alarcon E., Boada M., Buendia M., Canabate P., Carracedo A., Diego S., Gailhajenet A., Guitart M., Ibarria M., Lafuente A., Maronas O., Martin E., Martinez M. T., Marquie M., Mauleon A., Moreno M., Orellana A., Pancho A., Peleja E., Preckler S., Real L. M., Ruiz A., Saez M. E., Serrano-Rios M., Tarraga L., Vargas L., Adarmes-Gomez A. D., Alonso M. D., Alvarez V., Amer-Ferrer G., Antequera M., Bernal M., Bullido M. J., Burguera J. A., Carrillo F., Carrion-Claro M., Casajeros M. J., Clarimon J., Cruz-Gamero J. M., de Pancorbo M. M., Escuela R., Garrote-Espina L., Garcia-Alberca J. M., Garcia Madrona S., Garcia-Ribas G., Gomez-Garre P., Hevilla S., Jesus S., Labrador Espinosa M. A., Legaz A., Lleo A., Lopez de Munain A., Macias-Garcia D., Manzanares S., Marin M., Marin-Munoz J., Marin T., Martinez B., Martinez V., Martinez-Lage Alvarez P., Medina M., Mendioroz Iriarte M., Mir P., Molinuevo J. L., Pastor P., Perez Tur J., Perinan-Tocino T., Pineda-Sanchez R., Pinol-Ripoll G., Real de Asua D., Rodrigo S., Sanchez del Valle Diaz R., Sanchez-Juan P., Sastre I., Vicente M. P., Vigo-Ortega R., Vivancos L., Macleod C., McCracken C., Brayne C., Bresner C., Grozeva D., Bellou E., Sommerville E. W., Matthews F., Leonenko G., Menzies G., Windle G., Harwood J., Phillips J., Bennett K., Luckuck L., Clare L., Woods R., Saad S., Burholt V., Kehoe P. G., Scheltens P., Holstege H., Amouyel P., Schellenberg G. D., Williams J., Seshadri S., van Duijn C. M., Mather K. A., Sanchez-Valle R., Blennow K., Huisman M., Andreassen O. A., Posthuma D., van der Flier W. M., Ramirez A., Lambert J. -C., van der Lee S. J., de Rojas I., de Rojas, I, Moreno-Grau, S, Tesi, N, Grenier-Boley, B, Andrade, V, Jansen, I, Pedersen, N, Stringa, N, Zettergren, A, Hernandez, I, Montrreal, L, Antunez, C, Antonell, A, Tankard, R, Bis, J, Sims, R, Bellenguez, C, Quintela, I, Gonzalez-Perez, A, Calero, M, Franco-Macias, E, Macias, J, Blesa, R, Cervera-Carles, L, Menendez-Gonzalez, M, Frank-Garcia, A, Royo, J, Moreno, F, Huerto Vilas, R, Baquero, M, Diez-Fairen, M, Lage, C, Garcia-Madrona, S, Garcia-Gonzalez, P, Alarcon-Martin, E, Valero, S, Sotolongo-Grau, O, Ullgren, A, Naj, A, Lemstra, A, Benaque, A, Perez-Cordon, A, Benussi, A, Rabano, A, Padovani, A, Squassina, A, de Mendonca, A, Arias Pastor, A, Kok, A, Meggy, A, Pastor, A, Espinosa, A, Corma-Gomez, A, Martin Montes, A, Sanabria, A, Destefano, A, Schneider, A, Haapasalo, A, Kinhult Stahlbom, A, Tybjaerg-Hansen, A, Hartmann, A, Spottke, A, Corbaton-Anchuelo, A, Rongve, A, Borroni, B, Arosio, B, Nacmias, B, Nordestgaard, B, Kunkle, B, Charbonnier, C, Abdelnour, C, Masullo, C, Martinez Rodriguez, C, Munoz-Fernandez, C, Dufouil, C, Graff, C, Ferreira, C, Chillotti, C, Reynolds, C, Fenoglio, C, Van Broeckhoven, C, Clark, C, Pisanu, C, Satizabal, C, Holmes, C, Buiza-Rueda, D, Aarsland, D, Rujescu, D, Alcolea, D, Galimberti, D, Wallon, D, Seripa, D, Grunblatt, E, Dardiotis, E, Duzel, E, Scarpini, E, Conti, E, Rubino, E, Gelpi, E, Rodriguez-Rodriguez, E, Duron, E, Boerwinkle, E, Ferri, E, Tagliavini, F, Kucukali, F, Pasquier, F, Sanchez-Garcia, F, Mangialasche, F, Jessen, F, Nicolas, G, Selbaek, G, Ortega, G, Chene, G, Hadjigeorgiou, G, Rossi, G, Spalletta, G, Giaccone, G, Grande, G, Binetti, G, Papenberg, G, Hampel, H, Bailly, H, Zetterberg, H, Soininen, H, Karlsson, I, Alvarez, I, Appollonio, I, Giegling, I, Skoog, I, Saltvedt, I, Rainero, I, Rosas Allende, I, Hort, J, Diehl-Schmid, J, Van Dongen, J, Vidal, J, Lehtisalo, J, Wiltfang, J, Thomassen, J, Kornhuber, J, Haines, J, Vogelgsang, J, Pineda, J, Fortea, J, Popp, J, Deckert, J, Buerger, K, Morgan, K, Fliessbach, K, Sleegers, K, Molina-Porcel, L, Kilander, L, Weinhold, L, Farrer, L, Wang, L, Kleineidam, L, Farotti, L, Parnetti, L, Tremolizzo, L, Hausner, L, Benussi, L, Froelich, L, Ikram, M, Deniz-Naranjo, M, Tsolaki, M, Rosende-Roca, M, Lowenmark, M, Hulsman, M, Spallazzi, M, Pericak-Vance, M, Esiri, M, Bernal Sanchez-Arjona, M, Dalmasso, M, Martinez-Larrad, M, Arcaro, M, Nothen, M, Fernandez-Fuertes, M, Dichgans, M, Ingelsson, M, Herrmann, M, Scherer, M, Vyhnalek, M, Kosmidis, M, Yannakoulia, M, Schmid, M, Ewers, M, Heneka, M, Wagner, M, Scamosci, M, Kivipelto, M, Hiltunen, M, Zulaica, M, Alegret, M, Fornage, M, Roberto, N, van Schoor, N, Seidu, N, Banaj, N, Armstrong, N, Scarmeas, N, Scherbaum, N, Goldhardt, O, Hanon, O, Peters, O, Skrobot, O, Quenez, O, Lerch, O, Bossu, P, Caffarra, P, Dionigi Rossi, P, Sakka, P, Mecocci, P, Hoffmann, P, Holmans, P, Fischer, P, Riederer, P, Yang, Q, Marshall, R, Kalaria, R, Mayeux, R, Vandenberghe, R, Cecchetti, R, Ghidoni, R, Frikke-Schmidt, R, Sorbi, S, Hagg, S, Engelborghs, S, Helisalmi, S, Botne Sando, S, Kern, S, Archetti, S, Boschi, S, Fostinelli, S, Gil, S, Mendoza, S, Mead, S, Ciccone, S, Djurovic, S, Heilmann-Heimbach, S, Riedel-Heller, S, Kuulasmaa, T, del Ser, T, Lebouvier, T, Polak, T, Ngandu, T, Grimmer, T, Bessi, V, Escott-Price, V, Giedraitis, V, Deramecourt, V, Maier, W, Jian, X, Pijnenburg, Y, Smith, A, Saenz, A, Bizzarro, A, Lauria, A, Vacca, A, Solomon, A, Anastasiou, A, Richardson, A, Boland, A, Koivisto, A, Daniele, A, Greco, A, Marianthi, A, Mcguinness, B, Fin, B, Ferrari, C, Custodero, C, Ferrarese, C, Ingino, C, Mangone, C, Reyes Toso, C, Martinez, C, Cuesta, C, Muchnik, C, Joachim, C, Ortiz, C, Besse, C, Johansson, C, Zoia, C, Laske, C, Anastasiou, C, Palacio, D, Politis, D, Janowitz, D, Craig, D, Mann, D, Neary, D, Jurgen, D, Daian, D, Belezhanska, D, Kohler, E, Castano, E, Koutsouraki, E, Chipi, E, De Roeck, E, Costantini, E, Vardy, E, Piras, F, Roveta, F, Prestia, F, Assogna, F, Salani, F, Sala, G, Lacidogna, G, Novack, G, Wilcock, G, Thonberg, H, Kolsch, H, Weber, H, Boecker, H, Etchepareborda, I, Piaceri, I, Tuomilehto, J, Lindstrom, J, Laczo, J, Johnston, J, Deleuze, J, Harris, J, Schott, J, Priller, J, Bacha, J, Snowden, J, Lisso, J, Mihova, K, Traykov, L, Morelli, L, Brusco, L, Rainer, M, Takalo, M, Bjerke, M, Del Zompo, M, Serpente, M, Sanchez Abalos, M, Rios, M, Peltonen, M, Herrman, M, Kohler, M, Rojo, M, Jones, M, Orsini, M, Medel, N, Olivar, N, Fox, N, Salvadori, N, Hooper, N, Galeano, P, Solis, P, Bastiani, P, Passmore, P, Heun, R, Antikainen, R, Olaso, R, Perneczky, R, Germani, S, Lopez-Garcia, S, Love, S, Mehrabian, S, Bagnoli, S, Kochen, S, Andreoni, S, Teipel, S, Todd, S, Pickering-Brown, S, Natunen, T, Tegos, T, Laatikainen, T, Strandberg, T, Polvikoski, T, Matoska, V, Ciullo, V, Cores, V, Solfrizzi, V, Lisetti, V, Sevillano, Z, Aguilera, N, Alarcon, E, Boada, M, Buendia, M, Canabate, P, Carracedo, A, Diego, S, Gailhajenet, A, Guitart, M, Ibarria, M, Lafuente, A, Maronas, O, Martin, E, Martinez, M, Marquie, M, Mauleon, A, Moreno, M, Orellana, A, Pancho, A, Peleja, E, Preckler, S, Real, L, Ruiz, A, Saez, M, Serrano-Rios, M, Tarraga, L, Vargas, L, Adarmes-Gomez, A, Alonso, M, Alvarez, V, Amer-Ferrer, G, Antequera, M, Bernal, M, Bullido, M, Burguera, J, Carrillo, F, Carrion-Claro, M, Casajeros, M, Clarimon, J, Cruz-Gamero, J, de Pancorbo, M, Escuela, R, Garrote-Espina, L, Garcia-Alberca, J, Garcia Madrona, S, Garcia-Ribas, G, Gomez-Garre, P, Hevilla, S, Jesus, S, Labrador Espinosa, M, Legaz, A, Lleo, A, Lopez de Munain, A, Macias-Garcia, D, Manzanares, S, Marin, M, Marin-Munoz, J, Marin, T, Martinez, B, Martinez, V, Martinez-Lage Alvarez, P, Medina, M, Mendioroz Iriarte, M, Mir, P, Molinuevo, J, Pastor, P, Perez Tur, J, Perinan-Tocino, T, Pineda-Sanchez, R, Pinol-Ripoll, G, Real de Asua, D, Rodrigo, S, Sanchez del Valle Diaz, R, Sanchez-Juan, P, Sastre, I, Vicente, M, Vigo-Ortega, R, Vivancos, L, Macleod, C, Mccracken, C, Brayne, C, Bresner, C, Grozeva, D, Bellou, E, Sommerville, E, Matthews, F, Leonenko, G, Menzies, G, Windle, G, Harwood, J, Phillips, J, Bennett, K, Luckuck, L, Clare, L, Woods, R, Saad, S, Burholt, V, Kehoe, P, Scheltens, P, Holstege, H, Amouyel, P, Schellenberg, G, Williams, J, Seshadri, S, van Duijn, C, Mather, K, Sanchez-Valle, R, Blennow, K, Huisman, M, Andreassen, O, Posthuma, D, van der Flier, W, Ramirez, A, Lambert, J, van der Lee, S, de Rojas I., Moreno-Grau S., Tesi N., Grenier-Boley B., Andrade V., Jansen I. E., Pedersen N. L., Stringa N., Zettergren A., Hernandez I., Montrreal L., Antunez C., Antonell A., Tankard R. M., Bis J. C., Sims R., Bellenguez C., Quintela I., Gonzalez-Perez A., Calero M., Franco-Macias E., Macias J., Blesa R., Cervera-Carles L., Menendez-Gonzalez M., Frank-Garcia A., Royo J. L., Moreno F., Huerto Vilas R., Baquero M., Diez-Fairen M., Lage C., Garcia-Madrona S., Garcia-Gonzalez P., Alarcon-Martin E., Valero S., Sotolongo-Grau O., Ullgren A., Naj A. C., Lemstra A. W., Benaque A., Perez-Cordon A., Benussi A., Rabano A., Padovani A., Squassina A., de Mendonca A., Arias Pastor A., Kok A. A. L., Meggy A., Pastor A. B., Espinosa A., Corma-Gomez A., Martin Montes A., Sanabria A., DeStefano A. L., Schneider A., Haapasalo A., Kinhult Stahlbom A., Tybjaerg-Hansen A., Hartmann A. M., Spottke A., Corbaton-Anchuelo A., Rongve A., Borroni B., Arosio B., Nacmias B., Nordestgaard B. G., Kunkle B. W., Charbonnier C., Abdelnour C., Masullo C., Martinez Rodriguez C., Munoz-Fernandez C., Dufouil C., Graff C., Ferreira C. B., Chillotti C., Reynolds C. A., Fenoglio C., Van Broeckhoven C., Clark C., Pisanu C., Satizabal C. L., Holmes C., Buiza-Rueda D., Aarsland D., Rujescu D., Alcolea D., Galimberti D., Wallon D., Seripa D., Grunblatt E., Dardiotis E., Duzel E., Scarpini E., Conti E., Rubino E., Gelpi E., Rodriguez-Rodriguez E., Duron E., Boerwinkle E., Ferri E., Tagliavini F., Kucukali F., Pasquier F., Sanchez-Garcia F., Mangialasche F., Jessen F., Nicolas G., Selbaek G., Ortega G., Chene G., Hadjigeorgiou G., Rossi G., Spalletta G., Giaccone G., Grande G., Binetti G., Papenberg G., Hampel H., Bailly H., Zetterberg H., Soininen H., Karlsson I. K., Alvarez I., Appollonio I., Giegling I., Skoog I., Saltvedt I., Rainero I., Rosas Allende I., Hort J., Diehl-Schmid J., Van Dongen J., Vidal J. -S., Lehtisalo J., Wiltfang J., Thomassen J. Q., Kornhuber J., Haines J. L., Vogelgsang J., Pineda J. A., Fortea J., Popp J., Deckert J., Buerger K., Morgan K., Fliessbach K., Sleegers K., Molina-Porcel L., Kilander L., Weinhold L., Farrer L. A., Wang L. -S., Kleineidam L., Farotti L., Parnetti L., Tremolizzo L., Hausner L., Benussi L., Froelich L., Ikram M. A., Deniz-Naranjo M. C., Tsolaki M., Rosende-Roca M., Lowenmark M., Hulsman M., Spallazzi M., Pericak-Vance M. A., Esiri M., Bernal Sanchez-Arjona M., Dalmasso M. C., Martinez-Larrad M. T., Arcaro M., Nothen M. M., Fernandez-Fuertes M., Dichgans M., Ingelsson M., Herrmann M. J., Scherer M., Vyhnalek M., Kosmidis M. H., Yannakoulia M., Schmid M., Ewers M., Heneka M. T., Wagner M., Scamosci M., Kivipelto M., Hiltunen M., Zulaica M., Alegret M., Fornage M., Roberto N., van Schoor N. M., Seidu N. M., Banaj N., Armstrong N. J., Scarmeas N., Scherbaum N., Goldhardt O., Hanon O., Peters O., Skrobot O. A., Quenez O., Lerch O., Bossu P., Caffarra P., Dionigi Rossi P., Sakka P., Mecocci P., Hoffmann P., Holmans P. A., Fischer P., Riederer P., Yang Q., Marshall R., Kalaria R. N., Mayeux R., Vandenberghe R., Cecchetti R., Ghidoni R., Frikke-Schmidt R., Sorbi S., Hagg S., Engelborghs S., Helisalmi S., Botne Sando S., Kern S., Archetti S., Boschi S., Fostinelli S., Gil S., Mendoza S., Mead S., Ciccone S., Djurovic S., Heilmann-Heimbach S., Riedel-Heller S., Kuulasmaa T., del Ser T., Lebouvier T., Polak T., Ngandu T., Grimmer T., Bessi V., Escott-Price V., Giedraitis V., Deramecourt V., Maier W., Jian X., Pijnenburg Y. A. L., Smith A. D., Saenz A., Bizzarro A., Lauria A., Vacca A., Solomon A., Anastasiou A., Richardson A., Boland A., Koivisto A., Daniele A., Greco A., Marianthi A., McGuinness B., Fin B., Ferrari C., Custodero C., Ferrarese C., Ingino C., Mangone C., Reyes Toso C., Martinez C., Cuesta C., Muchnik C., Joachim C., Ortiz C., Besse C., Johansson C., Zoia C. P., Laske C., Anastasiou C., Palacio D. L., Politis D. G., Janowitz D., Craig D., Mann D. M., Neary D., Jurgen D., Daian D., Belezhanska D., Kohler E., Castano E. M., Koutsouraki E., Chipi E., De Roeck E., Costantini E., Vardy E. R. L. C., Piras F., Roveta F., Prestia F. A., Assogna F., Salani F., Sala G., Lacidogna G., Novack G., Wilcock G., Thonberg H., Kolsch H., Weber H., Boecker H., Etchepareborda I., Piaceri I., Tuomilehto J., Lindstrom J., Laczo J., Johnston J., Deleuze J. -F., Harris J., Schott J. M., Priller J., Bacha J. I., Snowden J., Lisso J., Mihova K. Y., Traykov L., Morelli L., Brusco L. I., Rainer M., Takalo M., Bjerke M., Del Zompo M., Serpente M., Sanchez Abalos M., Rios M., Peltonen M., Herrman M. J., Kohler M., Rojo M., Jones M., Orsini M., Medel N., Olivar N., Fox N. C., Salvadori N., Hooper N. M., Galeano P., Solis P., Bastiani P., Passmore P., Heun R., Antikainen R., Olaso R., Perneczky R., Germani S., Lopez-Garcia S., Love S., Mehrabian S., Bagnoli S., Kochen S., Andreoni S., Teipel S., Todd S., Pickering-Brown S., Natunen T., Tegos T., Laatikainen T., Strandberg T., Polvikoski T. M., Matoska V., Ciullo V., Cores V., Solfrizzi V., Lisetti V., Sevillano Z., Aguilera N., Alarcon E., Boada M., Buendia M., Canabate P., Carracedo A., Diego S., Gailhajenet A., Guitart M., Ibarria M., Lafuente A., Maronas O., Martin E., Martinez M. T., Marquie M., Mauleon A., Moreno M., Orellana A., Pancho A., Peleja E., Preckler S., Real L. M., Ruiz A., Saez M. E., Serrano-Rios M., Tarraga L., Vargas L., Adarmes-Gomez A. D., Alonso M. D., Alvarez V., Amer-Ferrer G., Antequera M., Bernal M., Bullido M. J., Burguera J. A., Carrillo F., Carrion-Claro M., Casajeros M. J., Clarimon J., Cruz-Gamero J. M., de Pancorbo M. M., Escuela R., Garrote-Espina L., Garcia-Alberca J. M., Garcia Madrona S., Garcia-Ribas G., Gomez-Garre P., Hevilla S., Jesus S., Labrador Espinosa M. A., Legaz A., Lleo A., Lopez de Munain A., Macias-Garcia D., Manzanares S., Marin M., Marin-Munoz J., Marin T., Martinez B., Martinez V., Martinez-Lage Alvarez P., Medina M., Mendioroz Iriarte M., Mir P., Molinuevo J. L., Pastor P., Perez Tur J., Perinan-Tocino T., Pineda-Sanchez R., Pinol-Ripoll G., Real de Asua D., Rodrigo S., Sanchez del Valle Diaz R., Sanchez-Juan P., Sastre I., Vicente M. P., Vigo-Ortega R., Vivancos L., Macleod C., McCracken C., Brayne C., Bresner C., Grozeva D., Bellou E., Sommerville E. W., Matthews F., Leonenko G., Menzies G., Windle G., Harwood J., Phillips J., Bennett K., Luckuck L., Clare L., Woods R., Saad S., Burholt V., Kehoe P. G., Scheltens P., Holstege H., Amouyel P., Schellenberg G. D., Williams J., Seshadri S., van Duijn C. M., Mather K. A., Sanchez-Valle R., Blennow K., Huisman M., Andreassen O. A., Posthuma D., van der Flier W. M., Ramirez A., Lambert J. -C., and van der Lee S. J.
- Abstract
The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was updated to add “P.M” between “P.D.” and “R.C.”. Additionally, the original version of this Article contained the incorrect affiliation for author Patrick Gavin Kehoe, which incorrectly read “German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany”. The correct version replaces this affiliation with “Bristol Medical School (THS), University of Bristol, Southmead Hospital, Bristol, UK”. This has been corrected in both the PDF and HTML versions of the Article.
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- 2023
8. Statin use and high-dose statin use after ischemic stroke in the UK: a retrospective cohort study
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Yang Z, Edwards D, Massou E, Saunders CL, Brayne C, and Mant J
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cerebral ischemia ,lipid-lowering ,trend ,factors ,Infectious and parasitic diseases ,RC109-216 - Abstract
Zhirong Yang,1 Duncan Edwards,1 Efthalia Massou,1 Catherine L Saunders,1 Carol Brayne,2 Jonathan Mant11Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK; 2Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UKBackground: Trial evidence supports statin use after ischemic stroke and recent American, European and British guidelines recommend high-intensity statins for this indication. Limited data are available describing current statin use among these patients in unselected settings. We conducted a cohort study to examine secular trends and factors associated with statin use and dose following ischemic stroke.Methods: A retrospective cohort study of patients with first ischemic stroke between 2000 and 2014 was conducted using the Clinical Practice Research Datalink (CPRD). Proportions of statin users and high-intensity statin users within 2 years after stroke were estimated for each calendar year. We used Cox regression models to explore potential factors associated with statin use and Poisson regression models to calculate risk ratios for the use of a high-intensity statin.Results: A total of 80,442 patients with first stroke were analyzed. The proportion using statins within 2 years after stroke increased from 25% in 2000 to 70% in 2006 and remained at about 75% through 2014. Among post-stroke statin users, high-intensity use accounted for approximately 15% between 2004 and 2011 and then increased to almost 35% in 2014. Older patients (aged ≥75 years), younger patients (
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- 2019
9. Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study
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Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., Di Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., Black, Sandra E., Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., O'Brien, John, Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.
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- 2018
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10. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS)
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Green, E, Gao, L, Barnes, R, Arthur, A, Baldwin, C, Barnes, L E, Brayne, C, Comas-Herrera, A, Dening, T, Forster, G, Harrison, S, Ince, P G, Jagger, C, Matthews, F E, McKeith, I G, Parry, B, Pickett, J, Robinson, L, Stephan, B C M, Wharton, S, Wittenberg, R, Woods, B, Weller, R, Kingston, Andrew, Wohland, Pia, Wittenberg, Raphael, Robinson, Louise, Brayne, Carol, Matthews, Fiona E, and Jagger, Carol
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- 2017
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11. The Vascular Impairment of Cognition Classification Consensus Study
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Taragano, F.E., Kril, J., Cavalieri, M., Jellinger, K.A., Kovacs, G.G., Engelborghs, S., Lafosse, C., Bertolucci, P.H., Brucki, S., Caramelli, P., de Toledo Ferraz Alves, T.C., Bocti, C., Fulop, T., Hogan, D.B., Hsiung, G.R., Kirk, A., Leach, L., Robillard, A., Sahlas, D.J., Guo, Q., Tian, J., Hokkanen, L., Jokinen, H., Benisty, S., Deramecourt, V., Hauw, J., Lenoir, H., Tsatali, M., Tsolaki, M., Sundar, U., Coen, R.F., Korczyn, A.D., Altieri, M., Baldereschi, M., Caltagirone, C., Caravaglios, G., Di Carlo, A., DI Piero, V., Gainotti, G., Galluzzi, S., Logroscino, G., Mecocci, P., Moretti, D.V., Padovani, A., Fukui, T., Ihara, M., Mizuno, T., Kim, S.Y., Akinyemi, R., Baiyewu, O., Ogunniyi, A., Szczudlik, A., Bastos-Leite, A.J., Firmino, H., Massano, J., Verdelho, A., Kruglov, L.S., Ikram, M.K., Kandiah, N., Arana, E., Barroso-Ribal, J., Calatayud, T., Cruz-Jentoft, A.J., López-Pousa, S., Martinez-Lage, P., Mataro, M., Börjesson-Hanson, A., Englund, E., Laukka, E.J., Qiu, C., Viitanen, M., Biessels, G.J., de Leeuw, F.-E., den Heijer, T., Exalto, L.G., Kappelle, L.J., Prins, N.D., Richard, E., Schmand, B., van den Berg, E., van der Flier, W.M., Bilgic, B., Allan, L.M., Archer, J., Attems, J., Bayer, A., Blackburn, D., Brayne, C., Bullock, R., Connelly, P.J., Farrant, A., Fish, M., Harkness, K., Ince, P.G., Langhorne, P., Mann, J., Matthews, F.E., Mayer, P., Pendlebury, S.T., Perneczky, R., Peters, R., Smithard, D., Stephan, B.C., Swartz, J.E., Todd, S., Werring, D.J., Wijayasiri, S.N., Wilcock, G., Zamboni, G., Au, R., Borson, S., Bozoki, A., Browndyke, J.N., Corrada, M.M., Crane, P.K., Diniz, B.S., Etcher, L., Fillit, H., Greenberg, S.M., Grinberg, L.T., Hurt, S.W., Lamar, M., Mielke, M., Ott, B.R., Perry, G., Powers, W.J., Ramos-Estebanez, C., Reed, B., Roberts, R.O., Romero, J.R., Saykin, A.J., Seshadri, S., Silbert, L., Stern, Y., Zarow, C., Skrobot, Olivia A., O'Brien, John, Black, Sandra, Chen, Christopher, DeCarli, Charles, Erkinjuntti, Timo, Ford, Gary A., Kalaria, Rajesh N., Pantoni, Leonardo, Pasquier, Florence, Roman, Gustavo C., Wallin, Anders, Sachdev, Perminder, Skoog, Ingmar, Ben-Shlomo, Yoav, Passmore, Anthony P., Love, Seth, and Kehoe, Patrick G.
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- 2017
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12. Using the GHQ-12 to screen for mental health problems among primary care patients: psychometrics and practical considerations
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Anjara, S. G., Bonetto, C., Van Bortel, T., and Brayne, C.
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- 2020
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13. What is a population-level approach to prevention, and how could we apply it to dementia risk reduction?
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Walsh, S., Wallace, L., Mukadam, N., Mytton, O., Lafortune, L., Wills, W., and Brayne, C.
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- 2023
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14. Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities
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King, D.L.O., Henson, R.N.A., Kievit, R.A., Wolpe, N., Brayne, C., Tyler, L.K., Geerligs, L., Villis, L., Tsvetanov, K.A., King, D.L.O., Henson, R.N.A., Kievit, R.A., Wolpe, N., Brayne, C., Tyler, L.K., Geerligs, L., Villis, L., and Tsvetanov, K.A.
- Abstract
Item does not contain fulltext, Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18–88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy in fluid relative to crystallized intelligence, indicative of cognitive decline, was associated with a latent vascular factor predominantly expressing pulse pressure. This suggests that higher pulse pressure is associated with cognitive decline from expected performance. The effect was stronger in older adults. Controlling pulse pressure may help to preserve cognition, particularly in older adults. Our findings highlight the need to better understand the multifactorial nature of vascular aging.
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- 2023
15. What would a population-level approach to dementia risk reduction look like, and how would it work?
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Walsh, S., Govia, I., Peters, Ruth, Richard, E., Stephan, B.C.M., Wilson, N.A., Wallace, L., Anstey, K.J., Brayne, C., Walsh, S., Govia, I., Peters, Ruth, Richard, E., Stephan, B.C.M., Wilson, N.A., Wallace, L., Anstey, K.J., and Brayne, C.
- Abstract
01 juli 2023, Contains fulltext : 296081.pdf (Publisher’s version ) (Open Access), Dementia is a leading global public health challenge. Prevention approaches have traditionally focused on individual-level strategies. However, such approaches have limited potential, particularly for resource-constrained populations in which exposure to risk factors is greatest, and exposure to protective factors is lowest. A population-level approach to dementia risk reduction is therefore essential to meet the scale of the challenge and to tackle global inequalities in risk and incidence of disease. Such approaches can be highly cost effective. In this viewpoint article, we describe what such an approach should look like, barriers and facilitators to success, and how we should go about achieving it. We include 10 strategic goals to achieve population-level dementia risk reduction and protection enhancement, targeted at researchers, professionals, funders, science communicators, governments, businesses, and policy makers. If we are to significantly reduce the prevalence of dementia there must be increased emphasis on population-level approaches. HIGHLIGHTS: Dementia risk reduction is a global public health priority Population-level approaches change societal conditions to make them less conducive to dementia's modifiable risk factors, and increase exposure to protective factors. Urgent development of population-level approaches is required to reduce the prevalence of, and inequalities in, dementia Action is required from researchers, governments and business, funders, public health professionals, and science communicators.
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- 2023
16. Authors' response to: A new dementia prevention approach requires new language.
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Walsh, S., Govia, I., Peters, Ruth, Richard, E., Stephan, B.C., Wilson, N.A., Wallace, L., Anstey, K.J., Brayne, C., Walsh, S., Govia, I., Peters, Ruth, Richard, E., Stephan, B.C., Wilson, N.A., Wallace, L., Anstey, K.J., and Brayne, C.
- Abstract
01 augustus 2023, Item does not contain fulltext
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- 2023
17. Evaluation of clinical benefits of treatments for Alzheimer's disease.
- Author
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Liu, K.Y., Walsh, S., Brayne, C., Merrick, R., Richard, E., Howard, R., Liu, K.Y., Walsh, S., Brayne, C., Merrick, R., Richard, E., and Howard, R.
- Abstract
Contains fulltext : 299991.pdf (Publisher’s version ) (Open Access), The need for regulatory approval of new therapies for the treatment of Alzheimer's disease-a progressive neurodegenerative condition-has made the assessment of treatment efficacy an urgent priority for discussion and investigation in the field. In the first part of this Personal View, we summarise current views on what constitutes a clinically meaningful benefit from treatment for Alzheimer's disease, including the concept of a minimum treatment effect against which to compare trial outcomes and its limitations. Considering existing and divergent definitions of clinically meaningful change, we define this concept in the second part of the Personal View by proposing a new approach that consecutively considers whether a treatment benefit for Alzheimer's disease is noticeable, valuable, and worthwhile in the context of costs and risks. This approach could be a useful foundation from which the field can move forwards on this issue and address existing gaps in understanding., 01 november 2023
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- 2023
18. Bayesian Analysis of Realistically Complex Models
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Best, N. G., Spiegelhalter, D. J., Thomas, A., and Brayne, C. E. G.
- Published
- 1996
- Full Text
- View/download PDF
19. LONG-LIVED PARENTS AND CARDIOVASCULAR OUTCOMES : 8 YEAR FOLLOW-UP IN 189,000 UK BIOBANK PARTICIPANTS
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Atkins, JL, Pilling, LC, Ble, A, Dutta, A, Harries, LW, Murray, A, Brayne, C, Robine, 6JM, Kuchel, GA, Ferrucci, L, and Melzer, D
- Published
- 2016
20. New insights into the genetic etiology of Alzheimer's disease and related dementias
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Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. 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D., Guitart, M., Moreno, M., Ibarria, M., Periñán, M., Aguilera, N., Gómez-Garre, P., Cañabate, P., Escuela, R., Pineda-Sánchez, R., Vigo-Ortega, R., Jesús, S., Preckler, S., Rodrigo-Herrero, S., Diego, S., Vacca, A., Roveta, F., Salvadori, N., Chipi, E., Boecker, H., Laske, C., Perneczky, R., Anastasiou, C., Janowitz, D., Malik, R., Anastasiou, A., Parveen, K., López-García, S., Antonell, A., Mihova, K. Y., Belezhanska, D., Weber, H., Kochen, S., Solis, P., Medel, N., Lisso, J., Sevillano, Z., Politis, D. G., Cores, V., Cuesta, C., Ortiz, C., Bacha, J. I., Rios, M., Saenz, A., Abalos, M. S., Kohler, E., Palacio, D. L., Etchepareborda, I., Kohler, M., Novack, G., Prestia, F. A., Galeano, P., Castaño, E. M., Germani, S., Toso, C. R., Rojo, M., Ingino, C., Mangone, C., Rubinsztein, D. C., Teipel, S., Fievet, N., Deramerourt, V., Forsell, C., Thonberg, H., Bjerke, M., Roeck, E. D., Martínez-Larrad, M. 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M, Rossi, P, Djurovic, S, Duron, E, Düzel, E, Dufouil, C, Eiriksdottir, G, Engelborghs, S, Escott-Price, V, Espinosa, A, Ewers, M, Faber, K, Fabrizio, T, Nielsen, S, Fardo, D, Farotti, L, Fenoglio, C, Fernández-Fuertes, M, Ferrari, R, Ferreira, C, Ferri, E, Fin, B, Fischer, P, Fladby, T, Fließbach, K, Fongang, B, Fornage, M, Fortea, J, Foroud, T, Fostinelli, S, Fox, N, Franco-Macías, E, Bullido, M, Frank-García, A, Froelich, L, Fulton-Howard, B, Galimberti, D, García-Alberca, J, García-González, P, Garcia-Madrona, S, Garcia-Ribas, G, Ghidoni, R, Giegling, I, Giorgio, G, Goate, A, Goldhardt, O, Gomez-Fonseca, D, González-Pérez, A, Graff, C, Grande, G, Green, E, Grimmer, T, Grünblatt, E, Grunin, M, Gudnason, V, Guetta-Baranes, T, Haapasalo, A, Hadjigeorgiou, G, Haines, J, Hamilton-Nelson, K, Hampel, H, Hanon, O, Hardy, J, Hartmann, A, Hausner, L, Harwood, J, Heilmann-Heimbach, S, Helisalmi, S, Heneka, M, Hernández, I, Herrmann, M, Hoffmann, P, Holmes, C, Holstege, H, Vilas, R, Hulsman, M, Humphrey, J, Biessels, G, Jian, X, Johansson, C, Jun, G, Kastumata, Y, Kauwe, J, Kehoe, P, Kilander, L, Ståhlbom, A, Kivipelto, M, Koivisto, A, Kornhuber, J, Kosmidis, M, Kukull, W, Kuksa, P, Kunkle, B, Kuzma, A, Lage, C, Laukka, E, Launer, L, Lauria, A, Lee, C, Lehtisalo, J, Lerch, O, Lleó, A, Longstreth, W, Lopez, O, de Munain, A, Love, S, Löwemark, M, Luckcuck, L, Lunetta, K, Ma, Y, Macías, J, Macleod, C, Maier, W, Mangialasche, F, Spallazzi, M, Marquié, M, Marshall, R, Martin, E, Montes, A, Rodríguez, C, Masullo, C, Mayeux, R, Mead, S, Mecocci, P, Medina, M, Meggy, A, Mehrabian, S, Mendoza, S, Menéndez-González, M, Mir, P, Moebus, S, Mol, M, Molina-Porcel, L, Montrreal, L, Morelli, L, Moreno, F, Morgan, K, Mosley, T, Nöthen, M, Muchnik, C, Mukherjee, S, Nacmias, B, Ngandu, T, Nicolas, G, Nordestgaard, B, Olaso, R, Orellana, A, Orsini, M, Ortega, G, Padovani, A, Paolo, C, Papenberg, G, Parnetti, L, Pasquier, F, Pastor, P, Peloso, G, Pérez-Cordón, A, Pérez-Tur, J, Pericard, P, Peters, O, Pijnenburg, Y, Pineda, J, Piñol-Ripoll, G, Pisanu, C, Polak, T, Popp, J, Posthuma, D, Priller, J, Puerta, R, Quenez, O, Quintela, I, Thomassen, J, Rábano, A, Rainero, I, Rajabli, F, Ramakers, I, Real, L, Reinders, M, Reitz, C, Reyes-Dumeyer, D, Ridge, P, Riedel-Heller, S, Riederer, P, Roberto, N, Rodriguez-Rodriguez, E, Rongve, A, Allende, I, Rosende-Roca, M, Royo, J, Rubino, E, Rujescu, D, Sáez, M, Sakka, P, Saltvedt, I, Sanabria, Á, Sánchez-Arjona, M, Sanchez-Garcia, F, Juan, P, Sánchez-Valle, R, Sando, S, Sarnowski, C, Satizabal, C, Scamosci, M, Scarmeas, N, Scarpini, E, Scheltens, P, Scherbaum, N, Scherer, M, Schmid, M, Schneider, A, Schott, J, Selbæk, G, Seripa, D, Serrano, M, Sha, J, Shadrin, A, Skrobot, O, Slifer, S, Snijders, G, Soininen, H, Solfrizzi, V, Solomon, A, Song, Y, Sorbi, S, Sotolongo-Grau, O, Spalletta, G, Spottke, A, Squassina, A, Stordal, E, Tartan, J, Tárraga, L, Tesí, N, Thalamuthu, A, Thomas, T, Tosto, G, Traykov, L, Tremolizzo, L, Tybjærg-Hansen, A, Uitterlinden, A, Ullgren, A, Ulstein, I, Valero, S, Valladares, O, Broeckhoven, C, Vance, J, Vardarajan, B, van der Lugt, A, Dongen, J, van Rooij, J, van Swieten, J, Vandenberghe, R, Verhey, F, Vidal, J, Vogelgsang, J, Vyhnalek, M, Wagner, M, Wallon, D, Wang, L, Wang, R, Weinhold, L, Wiltfang, J, Windle, G, Woods, B, Yannakoulia, M, Zare, H, Zhao, Y, Zhang, X, Zhu, C, Zulaica, M, Andreoni, S, Ferrarese, C, Sala, G, Zoia, C, Farrer, L, Psaty, B, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, M, de Mendonça, A, Hort, J, Tsolaki, M, Pericak-Vance, M, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimon, J, Deleuze, J, Rossi, G, Seshadri, S, Andreassen, O, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, G, van Duijn, C, Sims, R, van der Flier, W, Ruiz, A, Ramirez, A, Lambert, J, VU University medical center, Amsterdam Neuroscience - Neurodegeneration, Neurology, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, 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Sachdev, Perminder [0000-0002-9595-3220], Mather, Karen [0000-0003-4143-8941], Ikram, M Arfan [0000-0003-0372-8585], Tsolaki, Magda [0000-0002-2072-8010], Pericak-Vance, Margaret A [0000-0001-7283-8804], Amouyel, Philippe [0000-0001-9088-234X], Williams, Julie [0000-0002-4069-0259], Frikke-Schmidt, Ruth [0000-0003-4084-5027], Seshadri, Sudha [0000-0001-6135-2622], Andreassen, Ole A [0000-0002-4461-3568], Sleegers, Kristel [0000-0002-0283-2332], van Duijn, Cornelia M [0000-0002-2374-9204], Sims, Rebecca [0000-0002-3885-1199], van der Flier, Wiesje M [0000-0001-8766-6224], Ramirez, Alfredo [0000-0003-4991-763X], Lambert, Jean-Charles [0000-0003-0829-7817], Apollo - University of Cambridge Repository, Complex Trait Genetics, Clinical sciences, Neuroprotection & Neuromodulation, Pathologic Biochemistry and Physiology, Clinical Biology, Epidemiology, Internal Medicine, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. [0000-0002-6660-657X], Bullido, María J. [0000-0002-6477-1117], Goate, Alison M. [0000-0002-0576-2472], Herrmann, Martin J. [0000-0001-9970-2122], Jun, Gyungah R. [0000-0002-3230-8697], Kehoe, Patrick G. [0000-0002-7542-1139], Kosmidis, Mary H. [0000-0001-8790-1220], Lunetta, Kathryn L. [0000-0002-9268-810X], MacLeod, Catherine A. [0000-0002-9314-7380], Nöthen, Markus M. [0000-0002-8770-2464], Nordestgaard, Børge G. [0000-0002-1954-7220], Pineda, Juan A. [0000-0002-3751-0296], Real, Luis M. [0000-0003-4932-7429], Reinders, Marcel J. T. [0000-0002-1148-1562], Satizabal, Claudia L. [0000-0002-1115-4430], Schott, Jonathan M. [0000-0003-2059-024X], Shadrin, Alexey A. [0000-0002-7467-250X], Farrer, Lindsay A. [0000-0001-5533-4225], Psaty, Bruce M. [0000-0002-7278-2190], Ikram, M. Arfan [0000-0003-0372-8585], Pericak-Vance, Margaret A. [0000-0001-7283-8804], Andreassen, Ole A. [0000-0002-4461-3568], van Duijn, Cornelia M. [0000-0002-2374-9204], van der Flier, Wiesje M. [0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)
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tau Proteins/genetics ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Neurologi ,MED/03 - GENETICA MEDICA ,45/43 ,Medizin ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,genetics [Alzheimer Disease] ,Genome-Wide Association Study ,Humans ,tau Proteins ,Alzheimer Disease ,Cognitive Dysfunction ,VARIANTS ,pathology [Alzheimer Disease] ,Tau Proteins ,Settore BIO/13 - Biologia Applicata ,Cognitive Dysfunction/psychology ,692/699/375/365/1283 ,IMPUTATION ,article ,1184 Genetics, developmental biology, physiology ,Biología y Biomedicina / Biología ,AMYLOID-BETA ,Settore MED/26 - NEUROLOGIA ,Neurology ,psychology [Cognitive Dysfunction] ,Medical Genetics ,Human ,Neuroscience(all) ,631/208/205/2138 ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,ddc:570 ,Genetics ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,Medicinsk genetik ,MED/26 - NEUROLOGIA ,Alzheimer Disease/genetics ,neurology ,tau Protein ,NECROSIS-FACTOR-ALPHA ,RISK LOCI ,genetics [tau Proteins] ,PREDICTION MODELS ,Human medicine ,GENERATION ,RESPONSES - Abstract
25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not
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- 2022
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21. Are Population-Level Approaches to Dementia Risk Reduction Under-Researched? A Rapid Review of the Dementia Prevention Literature
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Walsh, S., primary, Wallace, L., additional, Kuhn, I., additional, Mytton, O., additional, Lafortune, L., additional, Wills, W., additional, Mukadam, N., additional, and Brayne, C., additional
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- 2023
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22. Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
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Dorsey, ER, Elbaz, A, Nichols, E, Abd-Allah, F, Abdelalim, A, Adsuar, JC, Ansha, MG, Brayne, C, Choi, J-YJ, Collado-Mateo, D, Dahodwala, N, Huyen, PD, Edessa, D, Endres, M, Fereshtehnejad, S-M, Foreman, KJ, Gbetoho Gankpe, F, Gupta, R, Hankey, GJ, Hay, SI, Hegazy, MI, Hibstu, DT, Kasaeian, A, Khader, Y, Khalil, I, Khang, Y-H, Kim, YJ, Kokubo, Y, Logroscino, G, Massano, J, Ibrahim, NM, Mohammed, AM, Mohammadi, A, Moradi-Lakeh, M, Naghavi, M, Binh, TN, Nirayo, YL, Ogbo, FA, Owolabi, MO, Pereira, DM, Postma, MJ, Qorbani, M, Rahman, MA, Roba, KT, Safari, H, Safiri, S, Satpathy, M, Sawhney, M, Shafieesabet, A, Shiferaw, MS, Smith, M, Szoeke, CEI, Tabares-Seisdedos, R, Nu, TT, Ukwaja, KN, Venketasubramanian, N, Villafaina, S, Weldegwergs, KG, Westerman, R, Wijeratne, T, Winkler, AS, Bach, TX, Yonemoto, N, Feigin, VL, Vos, T, and Murray, CJL
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Uncategorized - Abstract
[Background] Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. [Methods] Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. [Findings] In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. [Interpretation] Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. [Finding] Bill & Melinda Gates Foundation.
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- 2023
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23. Policies out of sync – are healthy ageing agendas fit for the future?
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Mavrodaris, A, primary, Lafortune, L, additional, and Brayne, C, additional
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- 2022
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24. Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019
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Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, A, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Akinyemi, R, Alahdab, F, Alanezi, F, Alipour, V, Ansari, I, Arabloo, J, Ashraf-Ganjouei, A, Avan, A, Ayano, G, Babar, Z, Baig, A, Banach, M, Barboza, M, Barker-Collo, S, Baune, B, Srikanth Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biondi, A, Birhan, T, Biswas, A, Bolla, S, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, R, Nagaraja, S, Carvalho, F, Castro-De-araujo, L, Catala-Lopez, F, Cerin, E, Cernigliaro, A, Cherbuin, N, Jasmine Choi, J, Chu, D, Dagnew, B, Dai, X, Dandona, L, Dandona, R, Diaz, D, Dibaji Forooshani, Z, Douiri, A, Duncan, B, Edvardsson, D, El-Jaafary, S, Eskandari, K, Eskandarieh, S, Feigin, V, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Gebregzabiher, K, Ghashghaee, A, Gholamian, A, Gnedovskaya, E, Golechha, M, Gupta, R, Hachinski, V, Hamidi, S, Hankey, G, Haro, J, Hassan, A, Hay, S, Heidari, G, Heidari-Soureshjani, R, Househ, M, Hussain, R, Hwang, B, Ilic, I, Ilic, M, Naghibi Irvani, S, Iso, H, Iwagami, M, Jha, R, Kalani, R, Kandel, H, Karch, A, Kasa, A, Kengne, A, Kim, Y, Kisa, S, Kisa, A, Kivimaki, M, Komaki, H, Aikoyanagi, Kukull, W, Kumar, G, Kumar, M, Landires, I, Leonardi, M, Lim, S, Liu, X, Logroscino, G, Lopez, A, Lorkowski, S, Loy, C, Amin, H, Manafi, N, Manjunatha, N, Mehndiratta, M, Menezes, R, Meretoja, A, Merkin, A, Metekiya, W, Misganaw, A, Mohajer, B, Ibrahim, N, Mohammad, Y, Mohapatra, A, Mohebi, F, Mokdad, A, Mondello, S, Mossie, T, Mulugeta, A, Nagel, G, Naveed, M, Nayak, V, Kandel, S, Nguyen, S, Nguyen, H, Nunez-Samudio, V, Ogbo, F, Olagunju, A, Orru, H, Ostojic, S, Ostroff, S, Otstavnov, N, Otstavnov, S, Owolabi, M, Pathak, M, Toroudi, H, Peterson, C, Pham, H, Phillips, M, Piradov, M, Pottoo, F, Prada, S, Angga Pribadi, D, Radfar, A, Raggi, A, Rahim, F, Ram, P, Rana, J, Rashedi, V, Rawaf, S, Rawaf, D, Reinig, N, Rezaei, N, Robinson, S, Romoli, M, Sachdev, P, Sahathevan, R, Sahebkar, A, Sahraian, M, Sattin, D, Saylan, M, Sayyah, M, Schiavolin, S, Schmidt, M, Shahid, I, Shaikh, M, Shigematsu, M, Shin, J, Shiri, R, Siddiqi, T, Silva, J, Singh, J, Soheili, A, Spurlock, E, Szoeke, C, Tabares-Seisdedos, R, Taddele, B, Thakur, B, Thekke Purakkal, A, Tovani-Palone, M, Tran, B, Travillian, R, Tripathi, M, Tsegaye, G, Usman, M, Vacante, M, Velazquez, D, Venketasubramanian, N, Vidale, S, Vlassov, V, Wang, Y, Wei, J, Weiss, J, Weldemariam, A, Wimo, A, Wu, C, Yadollahpour, A, Yamagishi, K, Yeshitila, Y, Yonemoto, N, Zadey, S, Zhang, Z, Murray, C, Vos, T, Nichols E., Abd-Allah F., Abdoli A., Abosetugn A. E., Abrha W. A., Abualhasan A., Abu-Gharbieh E., Akinyemi R. O., Alahdab F., Alanezi F. M., Alipour V., Ansari I., Arabloo J., Ashraf-Ganjouei A., Avan A., Ayano G., Babar Z. -U. -D., Baig A. A., Banach M., Barboza M. A., Barker-Collo S. L., Baune B. T., Srikanth Bhagavathula A., Bhattacharyya K., Bijani A., Biondi A., Birhan T. A., Biswas A., Bolla S. R., Boloor A., Brayne C., Brenner H., Burkart K., Burns R. A., Nagaraja S. B., Carvalho F., Castro-De-araujo L. F. S., Catala-Lopez F., Cerin E., Cernigliaro A., Cherbuin N., Jasmine Choi J. -Y., Chu D. -T., Dagnew B., Dai X., Dandona L., Dandona R., Diaz D., Dibaji Forooshani Z. S., Douiri A., Duncan B. B., Edvardsson D., El-Jaafary S. I., Eskandari K., Eskandarieh S., Feigin V. L., Fereshtehnejad S. -M., Fernandes E., Ferrara P., Filip I., Fischer F., Gaidhane S., Gebregzabiher K. Z., Ghashghaee A., Gholamian A., Gnedovskaya E. V., Golechha M., Gupta R., Hachinski V., Hamidi S., Hankey G. J., Haro J. M., Hassan A., Hay S. I., Heidari G., Heidari-Soureshjani R., Househ M., Hussain R., Hwang B. -F., Ilic I. M., Ilic M. D., Naghibi Irvani S. S., Iso H., Iwagami M., Jha R. P., Kalani R., Kandel H., Karch A., Kasa A. S., Kengne A. P., Kim Y. -E., Kim Y. J., Kisa S., Kisa A., Kivimaki M., Komaki H., Kukull W. A., Kumar G. A., Kumar M., Landires I., Leonardi M., Lim S. S., Liu X., Logroscino G., Lopez A. D., Lorkowski S., Loy C. T., Amin H. I. M., Manafi N., Manjunatha N., Mehndiratta M. M., Menezes R. G., Meretoja A., Merkin A., Metekiya W. M., Misganaw A. T., Mohajer B., Ibrahim N. M., Mohammad Y., Mohapatra A., Mohebi F., Mokdad A. H., Mondello S., Mossie T. B., Mulugeta A., Nagel G., Naveed M., Nayak V. C., Kandel S. N., Nguyen S. H., Nguyen H. L. T., Nunez-Samudio V., Ogbo F. A., Olagunju A. T., Orru H., Ostojic S. M., Ostroff S. M., Otstavnov N., Otstavnov S. S., Owolabi M. O., Pathak M., Toroudi H. P., Peterson C. B., Pham H. Q., Phillips M. R., Piradov M. A., Pottoo F. H., Prada S. I., Angga Pribadi D. R., Radfar A., Raggi A., Rahim F., Ram P., Rana J., Rashedi V., Rawaf S., Rawaf D. L., Reinig N., Rezaei N., Robinson S. R., Romoli M., Sachdev P. S., Sahathevan R., Sahebkar A., Sahraian M. A., Sattin D., Saylan M., Sayyah M., Schiavolin S., Schmidt M. I., Shahid I., Shaikh M. A., Shigematsu M., Shin J. I., Shiri R., Siddiqi T. J., Silva J. P., Singh J. A., Soheili A., Spurlock E. E., Szoeke C. E. I., Tabares-Seisdedos R., Taddele B. W., Thakur B., Thekke Purakkal A. S., Tovani-Palone M. R., Tran B. X., Travillian R. S., Tripathi M., Tsegaye G. W., Usman M. S., Vacante M., Velazquez D. Z., Venketasubramanian N., Vidale S., Vlassov V., Wang Y. -P., Wei J., Weiss J., Weldemariam A. H., Wimo A., Wu C., Yadollahpour A., Yamagishi K., Yeshitila Y. G., Yonemoto N., Zadey S., Zhang Z. -J., Murray C. J. L., Vos T., Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, A, Abrha, W, Abualhasan, A, Abu-Gharbieh, E, Akinyemi, R, Alahdab, F, Alanezi, F, Alipour, V, Ansari, I, Arabloo, J, Ashraf-Ganjouei, A, Avan, A, Ayano, G, Babar, Z, Baig, A, Banach, M, Barboza, M, Barker-Collo, S, Baune, B, Srikanth Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biondi, A, Birhan, T, Biswas, A, Bolla, S, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, R, Nagaraja, S, Carvalho, F, Castro-De-araujo, L, Catala-Lopez, F, Cerin, E, Cernigliaro, A, Cherbuin, N, Jasmine Choi, J, Chu, D, Dagnew, B, Dai, X, Dandona, L, Dandona, R, Diaz, D, Dibaji Forooshani, Z, Douiri, A, Duncan, B, Edvardsson, D, El-Jaafary, S, Eskandari, K, Eskandarieh, S, Feigin, V, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Gebregzabiher, K, Ghashghaee, A, Gholamian, A, Gnedovskaya, E, Golechha, M, Gupta, R, Hachinski, V, Hamidi, S, Hankey, G, Haro, J, Hassan, A, Hay, S, Heidari, G, Heidari-Soureshjani, R, Househ, M, Hussain, R, Hwang, B, Ilic, I, Ilic, M, Naghibi Irvani, S, Iso, H, Iwagami, M, Jha, R, Kalani, R, Kandel, H, Karch, A, Kasa, A, Kengne, A, Kim, Y, Kisa, S, Kisa, A, Kivimaki, M, Komaki, H, Aikoyanagi, Kukull, W, Kumar, G, Kumar, M, Landires, I, Leonardi, M, Lim, S, Liu, X, Logroscino, G, Lopez, A, Lorkowski, S, Loy, C, Amin, H, Manafi, N, Manjunatha, N, Mehndiratta, M, Menezes, R, Meretoja, A, Merkin, A, Metekiya, W, Misganaw, A, Mohajer, B, Ibrahim, N, Mohammad, Y, Mohapatra, A, Mohebi, F, Mokdad, A, Mondello, S, Mossie, T, Mulugeta, A, Nagel, G, Naveed, M, Nayak, V, Kandel, S, Nguyen, S, Nguyen, H, Nunez-Samudio, V, Ogbo, F, Olagunju, A, Orru, H, Ostojic, S, Ostroff, S, Otstavnov, N, Otstavnov, S, Owolabi, M, Pathak, M, Toroudi, H, Peterson, C, Pham, H, Phillips, M, Piradov, M, Pottoo, F, Prada, S, Angga Pribadi, D, Radfar, A, Raggi, A, Rahim, F, Ram, P, Rana, J, Rashedi, V, Rawaf, S, Rawaf, D, Reinig, N, Rezaei, N, Robinson, S, Romoli, M, Sachdev, P, Sahathevan, R, Sahebkar, A, Sahraian, M, Sattin, D, Saylan, M, Sayyah, M, Schiavolin, S, Schmidt, M, Shahid, I, Shaikh, M, Shigematsu, M, Shin, J, Shiri, R, Siddiqi, T, Silva, J, Singh, J, Soheili, A, Spurlock, E, Szoeke, C, Tabares-Seisdedos, R, Taddele, B, Thakur, B, Thekke Purakkal, A, Tovani-Palone, M, Tran, B, Travillian, R, Tripathi, M, Tsegaye, G, Usman, M, Vacante, M, Velazquez, D, Venketasubramanian, N, Vidale, S, Vlassov, V, Wang, Y, Wei, J, Weiss, J, Weldemariam, A, Wimo, A, Wu, C, Yadollahpour, A, Yamagishi, K, Yeshitila, Y, Yonemoto, N, Zadey, S, Zhang, Z, Murray, C, Vos, T, Nichols E., Abd-Allah F., Abdoli A., Abosetugn A. E., Abrha W. A., Abualhasan A., Abu-Gharbieh E., Akinyemi R. O., Alahdab F., Alanezi F. M., Alipour V., Ansari I., Arabloo J., Ashraf-Ganjouei A., Avan A., Ayano G., Babar Z. -U. -D., Baig A. A., Banach M., Barboza M. A., Barker-Collo S. L., Baune B. T., Srikanth Bhagavathula A., Bhattacharyya K., Bijani A., Biondi A., Birhan T. A., Biswas A., Bolla S. R., Boloor A., Brayne C., Brenner H., Burkart K., Burns R. A., Nagaraja S. B., Carvalho F., Castro-De-araujo L. F. S., Catala-Lopez F., Cerin E., Cernigliaro A., Cherbuin N., Jasmine Choi J. -Y., Chu D. -T., Dagnew B., Dai X., Dandona L., Dandona R., Diaz D., Dibaji Forooshani Z. S., Douiri A., Duncan B. B., Edvardsson D., El-Jaafary S. I., Eskandari K., Eskandarieh S., Feigin V. L., Fereshtehnejad S. -M., Fernandes E., Ferrara P., Filip I., Fischer F., Gaidhane S., Gebregzabiher K. Z., Ghashghaee A., Gholamian A., Gnedovskaya E. V., Golechha M., Gupta R., Hachinski V., Hamidi S., Hankey G. J., Haro J. M., Hassan A., Hay S. I., Heidari G., Heidari-Soureshjani R., Househ M., Hussain R., Hwang B. -F., Ilic I. M., Ilic M. D., Naghibi Irvani S. S., Iso H., Iwagami M., Jha R. P., Kalani R., Kandel H., Karch A., Kasa A. S., Kengne A. P., Kim Y. -E., Kim Y. J., Kisa S., Kisa A., Kivimaki M., Komaki H., Kukull W. A., Kumar G. A., Kumar M., Landires I., Leonardi M., Lim S. S., Liu X., Logroscino G., Lopez A. D., Lorkowski S., Loy C. T., Amin H. I. M., Manafi N., Manjunatha N., Mehndiratta M. M., Menezes R. G., Meretoja A., Merkin A., Metekiya W. M., Misganaw A. T., Mohajer B., Ibrahim N. M., Mohammad Y., Mohapatra A., Mohebi F., Mokdad A. H., Mondello S., Mossie T. B., Mulugeta A., Nagel G., Naveed M., Nayak V. C., Kandel S. N., Nguyen S. H., Nguyen H. L. T., Nunez-Samudio V., Ogbo F. A., Olagunju A. T., Orru H., Ostojic S. M., Ostroff S. M., Otstavnov N., Otstavnov S. S., Owolabi M. O., Pathak M., Toroudi H. P., Peterson C. B., Pham H. Q., Phillips M. R., Piradov M. A., Pottoo F. H., Prada S. I., Angga Pribadi D. R., Radfar A., Raggi A., Rahim F., Ram P., Rana J., Rashedi V., Rawaf S., Rawaf D. L., Reinig N., Rezaei N., Robinson S. R., Romoli M., Sachdev P. S., Sahathevan R., Sahebkar A., Sahraian M. A., Sattin D., Saylan M., Sayyah M., Schiavolin S., Schmidt M. I., Shahid I., Shaikh M. A., Shigematsu M., Shin J. I., Shiri R., Siddiqi T. J., Silva J. P., Singh J. A., Soheili A., Spurlock E. E., Szoeke C. E. I., Tabares-Seisdedos R., Taddele B. W., Thakur B., Thekke Purakkal A. S., Tovani-Palone M. R., Tran B. X., Travillian R. S., Tripathi M., Tsegaye G. W., Usman M. S., Vacante M., Velazquez D. Z., Venketasubramanian N., Vidale S., Vlassov V., Wang Y. -P., Wei J., Weiss J., Weldemariam A. H., Wimo A., Wu C., Yadollahpour A., Yamagishi K., Yeshitila Y. G., Yonemoto N., Zadey S., Zhang Z. -J., Murray C. J. L., and Vos T.
- Abstract
Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally.
- Published
- 2021
25. Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study
- Author
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Nichols, E, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Afshin, A, Akinyemi, R, Alanezi, F, Alipour, V, Almasi-Hashiani, A, Arabloo, J, Ashraf-Ganjouei, A, Ayano, G, Ayuso-Mateos, J, Baig, A, Banach, M, Barboza, M, Barker-Collo, S, Baune, B, Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biswas, A, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burugina Nagaraja, S, Carvalho, F, Castro-de-Araujo, L, Catala-Lopez, F, Cerin, E, Cherbuin, N, Chu, D, Dai, X, de Sa-Junior, A, Djalalinia, S, Douiri, A, Edvardsson, D, El-Jaafary, S, Eskandarieh, S, Faro, A, Farzadfar, F, Feigin, V, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Galluzzo, L, Gebremeskel, G, Ghashghaee, A, Gialluisi, A, Gnedovskaya, E, Golechha, M, Gupta, R, Hachinski, V, Haider, M, Haile, T, Hamiduzzaman, M, Hankey, G, Hay, S, Heidari, G, Heidari-Soureshjani, R, Ho, H, Househ, M, Hwang, B, Iacoviello, L, Ilesanmi, O, Ilic, I, Ilic, M, Irvani, S, Iwagami, M, Iyamu, I, Jha, R, Kalani, R, Karch, A, Kasa, A, Khader, Y, Khan, E, Khatib, M, Kim, Y, Kisa, S, Kisa, A, Kivimaki, M, Koyanagi, A, Kumar, M, Landires, I, Lasrado, S, Li, B, Lim, S, Liu, X, Madhava Kunjathur, S, Majeed, A, Malik, P, Mehndiratta, M, Menezes, R, Mohammad, Y, Mohammed, S, Mokdad, A, Moni, M, Nagel, G, Naveed, M, Nayak, V, Nguyen, C, Nguyen, H, Nunez-Samudio, V, Olagunju, A, Ostroff, S, Otstavnov, N, Owolabi, M, Pashazadeh Kan, F, Patel, U, Phillips, M, Piradov, M, Pond, C, Pottoo, F, Prada, S, Radfar, A, Rahim, F, Rana, J, Rashedi, V, Rawaf, S, Rawaf, D, Reinig, N, Renzaho, A, Rezaei, N, Rezapour, A, Romoli, M, Roshandel, G, Sachdev, P, Sahebkar, A, Sahraian, M, Samaei, M, Saylan, M, Sha, F, Shaikh, M, Shibuya, K, Shigematsu, M, Shin, J, Shiri, R, Silva, D, Singh, J, Singhal, D, Skryabin, V, Skryabina, A, Soheili, A, Sotoudeh, H, Spurlock, E, Szoeke, C, Tabares-Seisdedos, R, Taddele, B, Tovani-Palone, M, Tsegaye, G, Vacante, M, Venketasubramanian, N, Vidale, S, Vlassov, V, Vu, G, Wang, Y, Weiss, J, Weldemariam, A, Westerman, R, Wimo, A, Winkler, A, Wu, C, Yadollahpour, A, Yesiltepe, M, Yonemoto, N, Yu, C, Zastrozhin, M, Zastrozhina, A, Zhang, Z, Murray, C, Vos, T, Nichols E., Abd-Allah F., Abdoli A., Abualhasan A., Abu-Gharbieh E., Afshin A., Akinyemi R. O., Alanezi F. M., Alipour V., Almasi-Hashiani A., Arabloo J., Ashraf-Ganjouei A., Ayano G., Ayuso-Mateos J. L., Baig A. A., Banach M., Barboza M. A., Barker-Collo S. L., Baune B. T., Bhagavathula A. S., Bhattacharyya K., Bijani A., Biswas A., Boloor A., Brayne C., Brenner H., Burkart K., Burugina Nagaraja S., Carvalho F., Castro-de-Araujo L. F. S., Catala-Lopez F., Cerin E., Cherbuin N., Chu D. -T., Dai X., de Sa-Junior A. R., Djalalinia S., Douiri A., Edvardsson D., El-Jaafary S. I., Eskandarieh S., Faro A., Farzadfar F., Feigin V. L., Fereshtehnejad S. -M., Fernandes E., Ferrara P., Filip I., Fischer F., Gaidhane S., Galluzzo L., Gebremeskel G. G., Ghashghaee A., Gialluisi A., Gnedovskaya E. V., Golechha M., Gupta R., Hachinski V., Haider M. R., Haile T. G., Hamiduzzaman M., Hankey G. J., Hay S. I., Heidari G., Heidari-Soureshjani R., Ho H. C., Househ M., Hwang B. -F., Iacoviello L., Ilesanmi O. S., Ilic I. M., Ilic M. D., Irvani S. S. N., Iwagami M., Iyamu I. O., Jha R. P., Kalani R., Karch A., Kasa A. S., Khader Y. S., Khan E. A., Khatib M. N., Kim Y. J., Kisa S., Kisa A., Kivimaki M., Koyanagi A., Kumar M., Landires I., Lasrado S., Li B., Lim S. S., Liu X., Madhava Kunjathur S., Majeed A., Malik P., Mehndiratta M. M., Menezes R. G., Mohammad Y., Mohammed S., Mokdad A. H., Moni M. A., Nagel G., Naveed M., Nayak V. C., Nguyen C. T., Nguyen H. L. T., Nunez-Samudio V., Olagunju A. T., Ostroff S. M., Otstavnov N., Owolabi M. O., Pashazadeh Kan F., Patel U. K., Phillips M. R., Piradov M. A., Pond C. D., Pottoo F. H., Prada S. I., Radfar A., Rahim F., Rana J., Rashedi V., Rawaf S., Rawaf D. L., Reinig N., Renzaho A. M. N., Rezaei N., Rezapour A., Romoli M., Roshandel G., Sachdev P. S., Sahebkar A., Sahraian M. A., Samaei M., Saylan M., Sha F., Shaikh M. A., Shibuya K., Shigematsu M., Shin J. I., Shiri R., Silva D. A. S., Singh J. A., Singhal D., Skryabin V. Y., Skryabina A. A., Soheili A., Sotoudeh H., Spurlock E. E., Szoeke C. E. I., Tabares-Seisdedos R., Taddele B. W., Tovani-Palone M. R., Tsegaye G. W., Vacante M., Venketasubramanian N., Vidale S., Vlassov V., Vu G. T., Wang Y. -P., Weiss J., Weldemariam A. H., Westerman R., Wimo A., Winkler A. S., Wu C., Yadollahpour A., Yesiltepe M., Yonemoto N., Yu C., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Murray C. J. 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P., Kalani R., Karch A., Kasa A. S., Khader Y. S., Khan E. A., Khatib M. N., Kim Y. J., Kisa S., Kisa A., Kivimaki M., Koyanagi A., Kumar M., Landires I., Lasrado S., Li B., Lim S. S., Liu X., Madhava Kunjathur S., Majeed A., Malik P., Mehndiratta M. M., Menezes R. G., Mohammad Y., Mohammed S., Mokdad A. H., Moni M. A., Nagel G., Naveed M., Nayak V. C., Nguyen C. T., Nguyen H. L. T., Nunez-Samudio V., Olagunju A. T., Ostroff S. M., Otstavnov N., Owolabi M. O., Pashazadeh Kan F., Patel U. K., Phillips M. R., Piradov M. A., Pond C. D., Pottoo F. H., Prada S. I., Radfar A., Rahim F., Rana J., Rashedi V., Rawaf S., Rawaf D. L., Reinig N., Renzaho A. M. N., Rezaei N., Rezapour A., Romoli M., Roshandel G., Sachdev P. S., Sahebkar A., Sahraian M. A., Samaei M., Saylan M., Sha F., Shaikh M. A., Shibuya K., Shigematsu M., Shin J. I., Shiri R., Silva D. A. S., Singh J. A., Singhal D., Skryabin V. Y., Skryabina A. A., Soheili A., Sotoudeh H., Spurlock E. E., Szoeke C. E. I., Tabares-Seisdedos R., Taddele B. W., Tovani-Palone M. R., Tsegaye G. W., Vacante M., Venketasubramanian N., Vidale S., Vlassov V., Vu G. T., Wang Y. -P., Weiss J., Weldemariam A. H., Westerman R., Wimo A., Winkler A. S., Wu C., Yadollahpour A., Yesiltepe M., Yonemoto N., Yu C., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Murray C. J. L., and Vos T.
- Abstract
Background: Data sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings. However, validation samples from nationally representative surveys allow for the development of algorithms for the prediction of dementia prevalence nationally. Methods: Using cognitive testing data and data on functional limitations from Wave A (2001–2003) of the ADAMS study (n = 744) and the 2000 wave of the HRS study (n = 6358) we estimated a two-dimensional item response theory model to calculate cognition and function scores for all individuals over 70. Based on diagnostic information from the formal clinical adjudication in ADAMS, we fit a logistic regression model for the classification of dementia status using cognition and function scores and applied this algorithm to the full HRS sample to calculate dementia prevalence by age and sex. Results: Our algorithm had a cross-validated predictive accuracy of 88% (86–90), and an area under the curve of 0.97 (0.97–0.98) in ADAMS. Prevalence was higher in females than males and increased over age, with a prevalence of 4% (3–4) in individuals 70–79, 11% (9–12) in individuals 80–89 years old, and 28% (22–35) in those 90 and older. Conclusions: Our model had similar or better accuracy as compared to previously reviewed algorithms for the prediction of dementia prevalence in HRS, while utilizing more flexible methods. These methods could be more easily generalized and utilized to estimate dementia prevalence in other national surveys.
- Published
- 2021
26. Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort
- Author
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Opdebeeck, C., Matthews, F. E., Wu, Y-T., Woods, R. T., Brayne, C., and Clare, L.
- Published
- 2018
- Full Text
- View/download PDF
27. Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease
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Hunter, S and Brayne, C
- Published
- 2018
- Full Text
- View/download PDF
28. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
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S., Abbafati C., Abbas K. M., Abbasi M., Abbasifard M., Abbasi-Kangevari M., Abbastabar H., Abd-Allah F., Abdelalim A., Abdollahi M., Abdollahpour I., Abolhassani H., Aboyans V., Abrams E. M., Abreu L. G., Abrigo M. R. M., Abu-Raddad L. J., Abushouk A. I., Acebedo A., Ackerman I. N., Adabi M., Adamu A. A., Adebayo O. M., Adekanmbi V., Adelson J. D., Adetokunboh O. O., Adham D., Afshari M., Afshin A., Agardh E. E., Agarwal G., Agesa K. M., Aghaali M., Aghamir S. M. K., Agrawal A., Ahmad T., Ahmadi A., Ahmadi M., Ahmadieh H., Ahmadpour E., Akalu T. Y., Akinyemi R. O., Akinyemiju T., Akombi B., Al-Aly Z., Alam K., Alam N., Alam S., Alam T., Alanzi T. M., Albertson S. B., Alcalde-Rabanal J. E., Alema N. M., Ali M., Ali S., Alicandro G., Alijanzadeh M., Alinia C., Alipour V., Aljunid S. M., Alla F., Allebeck P., Almasi-Hashiani A., Alonso J., Al-Raddadi R. M., Altirkawi K. A., Alvis-Guzman N., Alvis-Zakzuk N. J., Amini S., Amini-Rarani M., Aminorroaya A., Amiri F., Amit A. M. L., Amugsi D. A., Amul G. G. H., Anderlini D., Andrei C. L., Andrei T., Anjomshoa M., Ansari F., Ansari I., Ansari-Moghaddam A., Antonio C. A. T., Antony C. M., Antriyandarti E., Anvari D., Anwer R., Arabloo J., Arab-Zozani M., Aravkin A. Y., Ariani F., Arnlov J., Aryal K. K., Arzani A., Asadi-Aliabadi M., Asadi-Pooya A. A., Asghari B., Ashbaugh C., Atnafu D. D., Atre S. R., Ausloos F., Ausloos M., Ayala Quintanilla B. P., Ayano G., Ayanore M. A., Aynalem Y. A., Azari S., Azarian G., Azene Z. N., Babaee E., Badawi A., Bagherzadeh M., Bakhshaei M. H., Bakhtiari A., Balakrishnan S., Balalla S., Balassyano S., Banach M., Banik P. C., Bannick M. S., Bante A. B., Baraki A. G., Barboza M. A., Barker-Collo S. L., Barthelemy C. M., Barua L., Barzegar A., Basu S., Baune B. T., Bayati M., Bazmandegan G., Bedi N., Beghi E., Bejot Y., Bello A. K., Bender R. G., Bennett D. A., Bennitt F. B., Bensenor I. M., Benziger C. P., Berhe K., Bernabe E., Bertolacci G. J., Bhageerathy R., Bhala N., Bhandari D., Bhardwaj P., Bhattacharyya K., Bhutta Z. A., Bibi S., Biehl M. H., Bikbov B., Bin Sayeed M. S., Biondi A., Birihane B. M., Bisanzio D., Bisignano C., Biswas R. K., Bohlouli S., Bohluli M., Bolla S. R. R., Boloor A., Boon-Dooley A. S., Borges G., Borzi A. M., Bourne R., Brady O. J., Brauer M., Brayne C., Breitborde N. J. K., Brenner H., Briant P. S., Briggs A. M., Briko N. I., Britton G. B., Bryazka D., Buchbinder R., Bumgarner B. R., Busse R., Butt Z. A., Caetano dos Santos F. L., Camera L. L. A., Campos-Nonato I. R., Car J., Cardenas R., Carreras G., Carrero J. J., Carvalho F., Castaldelli-Maia J. M., Castaneda-Orjuela C. A., Castelpietra G., Castle C. D., Castro F., Catala-Lopez F., Causey K., Cederroth C. R., Cercy K. M., Cerin E., Chandan J. S., Chang A. R., Charlson F. J., Chattu V. K., Chaturvedi S., Chimed-Ochir O., Chin K. L., Cho D. Y., Christensen H., Chu D. -T., Chung M. T., Cicuttini F. M., Ciobanu L. G., Cirillo M., Collins E. L., Compton K., Conti S., Cortesi P. A., Costa V. M., Cousin E., Cowden R. G., Cowie B. C., Cromwell E. A., Cross D. H., Crowe C. S., Cruz J. A., Cunningham M., Dahlawi S. M. A., Damiani G., Dandona L., Dandona R., Darwesh A. M., Daryani A., Das J. K., Das Gupta R., das Neves J., Davila-Cervantes C. A., Davletov K., De Leo D., Dean F. E., DeCleene N. K., Deen A., Degenhardt L., Dellavalle R. P., Demeke F. M., Demsie D. G., Denova-Gutierrez E., Dereje N. D., Dervenis N., Desai R., Desalew A., Dessie G. A., Dharmaratne S. D., Dhungana G. P., Dianatinasab M., Diaz D., Dibaji Forooshani Z. S., Dingels Z. V., Dirac M. A., Djalalinia S., Do H. T., Dokova K., Dorostkar F., Doshi C. P., Doshmangir L., Douiri A., Doxey M. C., Driscoll T. R., Dunachie S. J., Duncan B. B., Duraes A. R., Eagan A. W., Ebrahimi Kalan M., Edvardsson D., Ehrlich J. R., El Nahas N., El Sayed I., El Tantawi M., Elbarazi I., Elgendy I. Y., Elhabashy H. R., El-Jaafary S. I., Elyazar I. R., Emamian M. H., Emmons-Bell S., Erskine H. E., Eshrati B., Eskandarieh S., Esmaeilnejad S., Esmaeilzadeh F., Esteghamati A., Estep K., Etemadi A., Etisso A. E., Farahmand M., Faraj A., Fareed M., Faridnia R., Farinha C. S. E. S., Farioli A., Faro A., Faruque M., Farzadfar F., Fattahi N., Fazlzadeh M., Feigin V. L., Feldman R., Fereshtehnejad S. -M., Fernandes E., Ferrari A. J., Ferreira M. L., Filip I., Fischer F., Fisher J. L., Fitzgerald R., Flohr C., Flor L. S., Foigt N. A., Folayan M. O., Force L. M., Fornari C., Foroutan M., Fox J. T., Freitas M., Fu W., Fukumoto T., Furtado J. M., Gad M. M., Gakidou E., Galles N. C., Gallus S., Gamkrelidze A., Garcia-Basteiro A. L., Gardner W. M., Geberemariyam B. S., Gebrehiwot A. M., Gebremedhin K. B., Gebreslassie A. A. A. A., Gershberg Hayoon A., Gething P. W., Ghadimi M., Ghadiri K., Ghafourifard M., Ghajar A., Ghamari F., Ghashghaee A., Ghiasvand H., Ghith N., Gholamian A., Gilani S. A., Gill P. S., Gitimoghaddam M., Giussani G., Goli S., Gomez R. 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M., Ilic M. D., Inbaraj L. R., Ippolito H., Irvani S. S. N., Islam M. M., Islam M., Islam S. M. S., Islami F., Iso H., Ivers R. Q., Iwu C. C. D., Iyamu I. O., Jaafari J., Jacobsen K. H., Jadidi-Niaragh F., Jafari H., Jafarinia M., Jahagirdar D., Jahani M. A., Jahanmehr N., Jakovljevic M., Jalali A., Jalilian F., James S. L., Janjani H., Janodia M. D., Jayatilleke A. U., Jeemon P., Jenabi E., Jha R. P., Jha V., Ji J. S., Jia P., John O., John-Akinola Y. O., Johnson C. O., Johnson S. C., Jonas J. B., Joo T., Joshi A., Jozwiak J. J., Jurisson M., Kabir A., Kabir Z., Kalani H., Kalani R., Kalankesh L. R., Kalhor R., Kamiab Z., Kanchan T., Karami Matin B., Karch A., Karim M. A., Karimi S. E., Kassa G. M., Kassebaum N. J., Katikireddi S. V., Kawakami N., Kayode G. A., Keddie S. H., Keller C., Kereselidze M., Khafaie M. A., Khalid N., Khan M., Khatab K., Khater M. M., Khatib M. N., Khayamzadeh M., Khodayari M. T., Khundkar R., Kianipour N., Kieling C., Kim D., Kim Y. -E., Kim Y. J., Kimokoti R. W., Kisa A., Kisa S., Kissimova-Skarbek K., Kivimaki M., Kneib C. J., Knudsen A. K. S., Kocarnik J. M., Kolola T., Kopec J. A., Kosen S., Koul P. A., Koyanagi A., Kravchenko M. A., Krishan K., Krohn K. J., Kuate Defo B., Kucuk Bicer B., Kumar G. A., Kumar M., Kumar P., Kumar V., Kumaresh G., Kurmi O. P., Kusuma D., Kyu H. H., La Vecchia C., Lacey B., Lal D. K., Lalloo R., Lam J. O., Lami F. H., Landires I., Lang J. J., Lansingh V. C., Larson S. L., Larsson A. O., Lasrado S., Lassi Z. S., Lau K. M. -M., Lavados P. M., Lazarus J. V., Ledesma J. R., Lee P. H., Lee S. W. H., LeGrand K. E., Leigh J., Leonardi M., Lescinsky H., Leung J., Levi M., Lewington S., Li S., Lim L. -L., Lin C., Lin R. -T., Linehan C., Linn S., Liu H. -C., Liu S., Liu Z., Looker K. J., Lopez A. D., Lopukhov P. D., Lorkowski S., Lotufo P. A., Lucas T. C. D., Lugo A., Lunevicius R., Lyons R. A., Ma J., MacLachlan J. H., Maddison E. R., Maddison R., Madotto F., Mahasha P. W., Mai H. T., Majeed A., Maled V., Maleki S., Malekzadeh R., Malta D. C., Mamun A. A., Manafi A., Manafi N., Manguerra H., Mansouri B., Mansournia M. A., Mantilla Herrera A. M., Maravilla J. C., Marks A., Martins-Melo F. R., Martopullo I., Masoumi S. Z., Massano J., Massenburg B. B., Mathur M. R., Maulik P. K., McAlinden C., McGrath J. J., McKee M., Mehndiratta M. M., Mehri F., Mehta K. M., Meitei W. B., Memiah P. T. N., Mendoza W., Menezes R. G., Mengesha E. W., Mengesha M. B., Mereke A., Meretoja A., Meretoja T. J., Mestrovic T., Miazgowski B., Miazgowski T., Michalek I. M., Mihretie K. M., Miller T. R., Mills E. J., Mirica A., Mirrakhimov E. M., Mirzaei H., Mirzaei M., Mirzaei-Alavijeh M., Misganaw A. T., Mithra P., Moazen B., Moghadaszadeh M., Mohamadi E., Mohammad D. K., Mohammad Y., Mohammad Gholi Mezerji N., Mohammadian-Hafshejani A., Mohammadifard N., Mohammadpourhodki R., Mohammed S., Mokdad A. H., Molokhia M., Momen N. C., Monasta L., Mondello S., Mooney M. D., Moosazadeh M., Moradi G., Moradi M., Moradi-Lakeh M., Moradzadeh R., Moraga P., Morales L., Morawska L., Moreno Velasquez I., Morgado-da-Costa J., Morrison S. D., Mosser J. F., Mouodi S., Mousavi S. M., Mousavi Khaneghah A., Mueller U. O., Munro S. B., Muriithi M. K., Musa K. I., Muthupandian S., Naderi M., Nagarajan A. J., Nagel G., Naghshtabrizi B., Nair S., Nandi A. K., Nangia V., Nansseu J. R., Nayak V. C., Nazari J., Negoi I., Negoi R. I., Netsere H. B. N., Ngunjiri J. W., Nguyen C. T., Nguyen J., Nguyen M., Nichols E., Nigatu D., Nigatu Y. T., Nikbakhsh R., Nixon M. R., Nnaji C. A., Nomura S., Norrving B., Noubiap J. J., Nowak C., Nunez-Samudio V., Otoiu A., Oancea B., Odell C. M., Ogbo F. A., Oh I. -H., Okunga E. W., Oladnabi M., Olagunju A. T., Olusanya B. O., Olusanya J. O., Oluwasanu M. M., Omar Bali A., Omer M. O., Ong K. L., Onwujekwe O. E., Orji A. U., Orpana H. M., Ortiz A., Ostroff S. M., Otstavnov N., Otstavnov S. S., Overland S., Owolabi M. O., P A M., Padubidri J. R., Pakhare A. P., Palladino R., Pana A., Panda-Jonas S., Pandey A., Park E. -K., Parmar P. G. K., Pasupula D. K., Patel S. K., Paternina-Caicedo A. J., Pathak A., Pathak M., Patten S. B., Patton G. C., Paudel D., Pazoki Toroudi H., Peden A. E., Pennini A., Pepito V. C. F., Peprah E. K., Pereira A., Pereira D. M., Perico N., Pham H. Q., Phillips M. R., Pigott D. M., Pilgrim T., Pilz T. M., Pirsaheb M., Plana-Ripoll O., Plass D., Pokhrel K. N., Polibin R. V., Polinder S., Polkinghorne K. R., Postma M. J., Pourjafar H., Pourmalek F., Pourmirza Kalhori R., Pourshams A., Poznanska A., Prada S. I., Prakash V., Pribadi D. R. A., Pupillo E., Quazi Syed Z., Rabiee M., Rabiee N., Radfar A., Rafiee A., Rafiei A., Raggi A., Rahimi-Movaghar A., Rahman M. A., Rajabpour-Sanati A., Rajati F., Ramezanzadeh K., Ranabhat C. L., Rao P. C., Rao S. J., Rasella D., Rastogi P., Rathi P., Rawaf D. L., Rawaf S., Rawal L., Razo C., Redford S. B., Reiner R. C., Reinig N., Reitsma M. B., Remuzzi G., Renjith V., Renzaho A. M. N., Resnikoff S., Rezaei N., Rezai M. S., Rezapour A., Rhinehart P. -A., Riahi S. M., Ribeiro A. L. P., Ribeiro D. C., Ribeiro D., Rickard J., Roberts N. L. S., Roberts S., Robinson S. R., Roever L., Rolfe S., Ronfani L., Roshandel G., Roth G. A., Rubagotti E., Rumisha S. F., Sabour S., Sachdev P. S., Saddik B., Sadeghi E., Sadeghi M., Saeidi S., Safi S., Safiri S., Sagar R., Sahebkar A., Sahraian M. A., Sajadi S. M., Salahshoor M. R., Salamati P., Salehi Zahabi S., Salem H., Salem M. R. R., Salimzadeh H., Salomon J. A., Salz I., Samad Z., Samy A. M., Sanabria J., Santomauro D. F., Santos I. S., Santos J. V., Santric-Milicevic M. M., Saraswathy S. Y. I., Sarmiento-Suarez R., Sarrafzadegan N., Sartorius B., Sarveazad A., Sathian B., Sathish T., Sattin D., Sbarra A. N., Schaeffer L. E., Schiavolin S., Schmidt M. I., Schutte A. E., Schwebel D. C., Schwendicke F., Senbeta A. M., Senthilkumaran S., Sepanlou S. G., Shackelford K. 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G., Yip P., Yonemoto N., Yoon S. -J., Yoosefi Lebni J., Younis M. Z., Younker T. P., Yousefi Z., Yousefifard M., Yousefinezhadi T., Yousuf A. Y., Yu C., Yusefzadeh H., Zahirian Moghadam T., Zaki L., Zaman S. B., Zamani M., Zamanian M., Zandian H., Zangeneh A., Zastrozhin M. S., Zewdie K. A., Zhang Y., Zhang Z. -J., Zhao J. T., Zhao Y., Zheng P., Zhou M., Ziapour A., Zimsen S. R. M., Naghavi M., and Murray C. J. L.
- Abstract
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value
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- 2020
29. Association of Systolic Blood Pressure With Dementia Risk and the Role of Age, U-Shaped Associations, and Mortality
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Dalen, J. van, Brayne, C., Crane, P.K., Fratiglioni, L., Larson, E.B., Lobo, A., Lobo, E., Marcum, Zachary A., Charante, E.P.M. van, Qiu, C., Riedel-Heller, S.G., Röhr, S., Rydén, L., Skoog, I., Gool, W.A. van, Richard, E., Dalen, J. van, Brayne, C., Crane, P.K., Fratiglioni, L., Larson, E.B., Lobo, A., Lobo, E., Marcum, Zachary A., Charante, E.P.M. van, Qiu, C., Riedel-Heller, S.G., Röhr, S., Rydén, L., Skoog, I., Gool, W.A. van, and Richard, E.
- Abstract
Item does not contain fulltext, IMPORTANCE: The optimal systolic blood pressure (SBP) to minimize the risk of dementia in older age is unknown. OBJECTIVE: To investigate whether the association between SBP and dementia risk is U-shaped and whether age and comorbidity play a role in this association. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used an individual participant data approach to analyze 7 prospective, observational, population-based cohort studies that were designed to evaluate incident dementia in older adults. These studies started between 1987 and 2006 in Europe and the US. Participants had no dementia diagnosis and had SBP and/or diastolic blood pressure (BP) data at baseline and incident dementia status during follow-up. Data analysis was conducted from November 7, 2019, to October 3, 2021. EXPOSURES: Baseline systolic BP. MAIN OUTCOMES AND MEASURES: All-cause dementia (defined using Diagnostic and Statistical Manual of Mental Disorders [Third Edition Revised] or Diagnostic and Statistical Manual of Mental Disorders [Fourth Edition] and established at follow-up measurements or in clinical practice), mortality, and combined dementia and mortality were the outcomes. Covariates included baseline antihypertensive medication use, sex, educational level, body mass index, smoking status, diabetes, stroke history, myocardial infarction history, and polypharmacy. Cox proportional hazards regression models were used, and nonlinear associations were explored using natural splines. RESULTS: The study analyzed 7 cohort studies with a total of 17 286 participants, among whom 10 393 were women (60.1%) and the mean (SD) baseline age was 74.5 (7.3) years. Overall, dementia risk was lower for individuals with higher SBP, with the lowest risk associated with an SBP of approximately 185 mm Hg (95% CI, 161-230 mm Hg; P = .001). Stratified by overlapping 10-year baseline age groups, the lowest dementia risk was observed at somewhat lower systolic BP levels in those older than 75 years (158 [95%
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- 2022
30. The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy - A Pooled Analysis of Two Randomized Controlled Trials
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Brok, M.G.H.E. den, Hoevenaar-Blom, M.P., Coley, N., Andrieu, S., Dalen, J. van, Meiller, Y., Guillemont, J., Brayne, C., Gool, W.A. van, Moll van Charante, E.P., Richard, E., Brok, M.G.H.E. den, Hoevenaar-Blom, M.P., Coley, N., Andrieu, S., Dalen, J. van, Meiller, Y., Guillemont, J., Brayne, C., Gool, W.A. van, Moll van Charante, E.P., and Richard, E.
- Abstract
Item does not contain fulltext, BACKGROUND: Cardiovascular risk factors and lifestyle factors are associated with an increased risk of cognitive decline and dementia in observational studies, and have been targeted by multidomain interventions. OBJECTIVES: We pooled individual participant data from two multi-domain intervention trials on cognitive function and symptoms of depression to increase power and facilitate subgroup analyses. DESIGN: Pooled analysis of individual participant data. SETTING: Prevention of Dementia by Intensive Vascular Care trial (preDIVA) and Multidomain Alzheimer Preventive Trial (MAPT). PARTICIPANTS: Community-dwelling individuals, free from dementia at baseline. INTERVENTION: Multidomain interventions focused on cardiovascular and lifestyle related risk factors. MEASUREMENTS: Data on cognitive functioning, depressive symptoms and apathy were collected at baseline, 2 years and 3-4 years of follow-up as available per study. We analyzed crude scores with linear mixed models for overall cognitive function (Mini Mental State Examination [MMSE]), and symptoms of depression and apathy (15-item Geriatric Depression Scale). Prespecified subgroup analyses were performed for sex, educational level, baseline MMSE <26, history of hypertension, and history of stroke, myocardial infarction and/or diabetes mellitus. RESULTS: We included 4162 individuals (median age 74 years, IQR 72, 76) with a median follow-up duration of 3.7 years (IQR 3.0 to 4.1 years). No differences between intervention and control groups were observed on change in cognitive functioning scores and symptoms of depression and apathy scores in the pooled study population. The MMSE declined less in the intervention groups in those with MMSE <26 at baseline (N=250; MD: 0.84; 95%CI: 0.15 to 1.54; p<0.001). CONCLUSIONS: We found no conclusive evidence that multidomain interventions reduce the risk of global cognitive decline, symptoms of depression or apathy in a mixed older population. Our results suggest that these inter
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- 2022
31. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
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Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Béjot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Cámera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catalá-López, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, DT, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, SI, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, SM, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, IR, Gnedovskaya, EV, Golechha, M, Gupta, R, Gupta, Veer, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, AI, Hasan, MT, Hassan, A, Nichols, E, Steinmetz, JD, Vollset, SE, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Akram, TT, Al Hamad, H, Alahdab, F, Alanezi, FM, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, Baig, AA, Barnett, A, Barrow, A, Baune, BT, Béjot, Y, Bezabhe, WMM, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Bolla, SR, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burns, RA, Cámera, LA, Cao, C, Carvalho, F, Castro-de-Araujo, LFS, Catalá-López, F, Cerin, E, Chavan, PP, Cherbuin, N, Chu, DT, Costa, VM, Couto, RAS, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, El-Jaafary, SI, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, Feigin, VL, Feng, X, Fereshtehnejad, SM, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Gilani, SA, Glavan, IR, Gnedovskaya, EV, Golechha, M, Gupta, R, Gupta, Veer, Gupta, VK, Haider, MR, Hall, BJ, Hamidi, S, Hanif, A, Hankey, GJ, Haque, S, Hartono, RK, Hasaballah, AI, Hasan, MT, and Hassan, A
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- 2022
32. Lecanemab for Alzheimer's disease
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Walsh, S., Merrick, R., Richard, E., Nurock, S., Brayne, C., Walsh, S., Merrick, R., Richard, E., Nurock, S., and Brayne, C.
- Abstract
Item does not contain fulltext
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- 2022
33. Chronic neuropsychiatric sequelae of SARS‐CoV‐2: Protocol and methods from the Alzheimer's Association Global Consortium
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de Erausquin, G.A., Snyder, H., Brugha, T.S., Seshadri, S., Carrillo, M., Sagar, R., Huang, Y., Newton, C., Tartaglia, C., Teunissen, C., Håkanson, K., Akinyemi, R., Prasad, K., D'Avossa, G., Gonzalez‐Aleman, G., Hosseini, A., Vavougios, G.D., Sachdev, P., Bankart, J., Mors, N.P.O., Lipton, R., Katz, M., Fox, P.T., Katshu, M.Z., Iyengar, M.S., Weinstein, G., Sohrabi, H.R., Jenkins, R., Stein, D.J., Hugon, J., Mavreas, V., Blangero, J., Cruchaga, C., Krishna, M., Wadoo, O., Becerra, R., Zwir, I., Longstreth, W.T., Kroenenberg, G., Edison, P., Mukaetova‐Ladinska, E., Staufenberg, E., Figueredo‐Aguiar, M., Yécora, A., Vaca, F., Zamponi, H.P., Re, V.L., Majid, A., Sundarakumar, J., Gonzalez, H.M., Geerlings, M.I., Skoog, I., Salmoiraghi, A., Boneschi, F.M., Patel, V.N., Santos, J.M., Arroyo, G.R., Moreno, A.C., Felix, P., Gallo, C., Arai, H., Yamada, M., Iwatsubo, T., Sharma, M., Chakraborty, N., Ferreccio, C., Akena, D., Brayne, C., Maestre, G., Blangero, S.W., Brusco, L.I., Siddarth, P., Hughes, T.M., Zuñiga, A.R., Kambeitz, J., Laza, A.R., Allen, N., Panos, S., Merrill, D., Ibáñez, A., Tsuang, D., Valishvili, N., Shrestha, S., Wang, S., Padma, V., Anstey, K.J., Ravindrdanath, V., Blennow, K., Mullins, P., Łojek, E., Pria, A., Mosley, T.H., Gowland, P., Girard, T.D., Bowtell, R., Vahidy, F.S., de Erausquin, G.A., Snyder, H., Brugha, T.S., Seshadri, S., Carrillo, M., Sagar, R., Huang, Y., Newton, C., Tartaglia, C., Teunissen, C., Håkanson, K., Akinyemi, R., Prasad, K., D'Avossa, G., Gonzalez‐Aleman, G., Hosseini, A., Vavougios, G.D., Sachdev, P., Bankart, J., Mors, N.P.O., Lipton, R., Katz, M., Fox, P.T., Katshu, M.Z., Iyengar, M.S., Weinstein, G., Sohrabi, H.R., Jenkins, R., Stein, D.J., Hugon, J., Mavreas, V., Blangero, J., Cruchaga, C., Krishna, M., Wadoo, O., Becerra, R., Zwir, I., Longstreth, W.T., Kroenenberg, G., Edison, P., Mukaetova‐Ladinska, E., Staufenberg, E., Figueredo‐Aguiar, M., Yécora, A., Vaca, F., Zamponi, H.P., Re, V.L., Majid, A., Sundarakumar, J., Gonzalez, H.M., Geerlings, M.I., Skoog, I., Salmoiraghi, A., Boneschi, F.M., Patel, V.N., Santos, J.M., Arroyo, G.R., Moreno, A.C., Felix, P., Gallo, C., Arai, H., Yamada, M., Iwatsubo, T., Sharma, M., Chakraborty, N., Ferreccio, C., Akena, D., Brayne, C., Maestre, G., Blangero, S.W., Brusco, L.I., Siddarth, P., Hughes, T.M., Zuñiga, A.R., Kambeitz, J., Laza, A.R., Allen, N., Panos, S., Merrill, D., Ibáñez, A., Tsuang, D., Valishvili, N., Shrestha, S., Wang, S., Padma, V., Anstey, K.J., Ravindrdanath, V., Blennow, K., Mullins, P., Łojek, E., Pria, A., Mosley, T.H., Gowland, P., Girard, T.D., Bowtell, R., and Vahidy, F.S.
- Abstract
Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmoni
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34. The Implications of Epidemiological Findings for the Prevention of Alzheimer’s Disease
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Brayne, C., Dufouil, C., McGee, M. A., Christen, Yves, editor, Mayeux, Richard, editor, and Christen, Y., editor
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- 1999
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35. Operational definition of Active and Healthy Ageing (AHA): A conceptual framework
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Bousquet, Jean, Kuh, D., Bewick, M., Standberg, T., Farrell, J., Pengelly, R., Joel, M. E., Rodriguez Mañas, L., Mercier, J., Bringer, J., Camuzat, T., Bourret, R., Bedbrook, A., Kowalski, M. L., Samolinski, B., Bonini, S., Brayne, C., Michel, J. P., Venne, J., Viriot-Durandal, P., Alonso, J., Avignon, A., Ben-Shlomo, Y., Bousquet, P. J., Combe, B., Cooper, R., Hardy, R., Iaccarino, G., Keil, T., Kesse-Guyot, E., Momas, I., Ritchie, K., Robine, J. M., Thijs, C., Tischer, C., Vellas, B., Zaidi, A., Alonso, F., Andersen Ranberg, K., Andreeva, V., Ankri, J., Arnavielhe, S., Arshad, H., Augé, P., Berr, C., Bertone, P., Blain, H., Blasimme, A., Buijs, G. J., Caimmi, D., Carriazo, A., Cesario, A., Coletta, J., Cosco, T., Criton, M., Cuisinier, F., Demoly, P., Fernandez-Nocelo, S., Fougère, B., Garcia-Aymerich, J., Goldberg, M., Guldemond, N., Gutter, Z., Harman, D., Hendry, A., Heve, D., Illario, M., Jeande, C., Krauss-Etschmann, S., Krys, O., Kula, D., Laune, D., Lehmann, S., Maier, D., Malva, J., Matignon, P., Melen, E., Mercier, G., Moda, G., Nizinkska, A., Nogues, M., O’Neill, M., Pelissier, J. Y., Poethig, D., Porta, D., Postma, D., Puisieux, F., Richards, M., Robalo-Cordeiro, C., Romano, V., Roubille, F., Schulz, H., Scott, A., Senesse, P., Slagter, S., Smit, H. A., Somekh, D., Stafford, M., Suanzes, J., Todo-Bom, A., Touchon, J., Traver-Salcedo, V., Van Beurden, M., Varraso, R., Vergara, I., Villalba-Mora, E., Wilson, N., Wouters, E., and Zins, M.
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- 2015
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36. Risk Prediction Models : A Framework for Assessment
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Dent, T.H.S., Wright, C.F., Stephan, B.C.M., Brayne, C., and Janssens, A.C.J.W.
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- 2012
37. Towards a Contemporary Design Framework for Systems-of-Systems Resilience
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Dreesbeimdiek, K. M., primary, von Behr, C.-M., additional, Brayne, C., additional, and Clarkson, P. J., additional
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- 2022
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38. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
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Abbafati, C., Machado, D.B., Cislaghi, B., Salman, O.M., Karanikolos, M., McKee, M., Abbas, K.M., Brady, O.J., Larson, H.J., Trias-Llimós, S., Cummins, S., Langan, S.M., Sartorius, B., Hafiz, A., Jenabi, E., Mohammad Gholi Mezerji, N., Borzouei, S., Azarian, G., Khazaei, S., Abbasi, M., Asghari, B., Masoumi, S., Komaki, H., Taherkhani, A., Adabi, M., Abbasifard, M., Bazmandegan, G., Kamiab, Z., Vakilian, A., Anjomshoa, M., Mokari, A., Sabour, S., Shahbaz, M., Saeedi, R., Ahmadieh, H., Yousefinezhadi, T., Haj-Mirzaian, A., Nikbakhsh, R., Safi, S., Asgari, S., Irvani, S.N., Jahanmehr, N., Ramezanzadeh, K., Abbasi-Kangevari, M., Khayamzadeh, M., Abbastabar, H., Shirkoohi, R., Fazlzadeh, M., Janjani, H., Hosseini, M., Mansournia, M., Tohidinik, H., Bakhtiari, A., Fazaeli, A., Mousavi, S., Hasanzadeh, A., Nabavizadeh, B., Malekzadeh, R., Hashemian, M., Pourshams, A., Salimzadeh, H., Sepanlou, S.G., Afarideh, M., Esteghamati, A., Esteghamati, S., Ghajar, A., Heidari, B., Rezaei, N., Mohamadi, E., Rahimi-Movaghar, A., Rahim, F., Eskandarieh, S., Sahraian, M., Mohebi, F., Aminorroaya, A., Ebrahimi, H., Farzadfar, F., Mohajer, B., Pishgar, F., Saeedi Moghaddam, S., Shabani, M., Zarafshan, H., Abolhassani, H., Hafezi-Nejad, N., Heidari-Soureshjani, R., Abdollahi, M., Farahmand, M., Salamati, P., Mehrabi Nasab, E., Tajdini, M., Aghamir, S., Mirzaei, R., Dibaji Forooshani, Z., Khater, M.M., Abd-Allah, F., Abdelalim, A., Abualhasan, A., El-Jaafary, S.I., Hassan, A., Elsharkawy, A., Khater, A.M., Elhabashy, H.R., Salem, M.R.R., Salem, H., Sadeghi, M., Jafarinia, M., Amini-Rarani, M., Mohammadifard, N., Sarrafzadegan, N., Abdollahpour, I., Sarveazad, A., Tehrani-Banihashemi, A., Yoosefi Lebni, J., Manafi, N., Pazoki Toroudi, H., Dorostkar, F., Alipour, V., Sheikhtaheri, A., Arabloo, J., Azari, S., Ghashghaee, A., Rezapour, A., Naserbakht, M., Kabir, A., Mehri, F., Yousefifard, M., Asadi-Aliabadi, M., Babaee, E., Eshrati, B., Goharinezhad, S., Moradi-Lakeh, M., Abedi, P., Rashedi, V., Kumar, V., Elgendy, I.Y., Basu, S., Park, J., Pereira, A., Norheim, O.F., Eagan, A.W., Cahill, L.E., Sheikh, A., Abushouk, A.I., Kraemer, M.U.G., Thakur, B., Bärnighausen, T.W., Shrime, M.G., Abedi, A., Doshi, C.P., Abegaz, K.H., Geberemariyam, B.S., Aynalem, Y.A., Shiferaw, W.S., Abosetugn, A.E., Aboyans, V., Abrams, E.M., Gitimoghaddam, M., Kissoon, N., Stubbs, J.L., Brauer, M., Iyamu, I.O., Kopec, J.A., Pourmalek, F., Ribeiro, A.P., Malta, D.C., Gomez, R.S., Abreu, L.G., Abrigo, M.R.M., Almulhim, A.M., Dahlawi, S.M.A., Pottoo, F.H., Menezes, R.G., Alanzi, T.M., Alumran, A.K., Abu Haimed, A.K., Madadin, M., Alanezi, F.M., Abu-Gharbieh, E., Saddik, B., Abu-Raddad, L.J., Samy, A.M., El Nahas, N., Shalash, A.S., Nabhan, A.F., Kamath, A.M., Kassebaum, N.J., Aravkin, A.Y., Kochhar, S., Sorensen, R.J.D., Afshin, A., Burkart, K., Cromwell, E.A., Dandona, L., Dharmaratne, S.D., Gakidou, E., Hay, S.I., Kyu, H.H., Lopez, A.D., Lozano, R., Misganaw, A.T., Mokdad, A.H., Naghavi, M., Pigott, D.M., Reiner Jr, R.C., Roth, G.A., Stanaway, J.D., Vollset, S., Vos, T., Wang, H., Lim, S.S., Murray, C.J.L., Kalani, R., Ikuta, K.S., Cho, D.Y., Kneib, C.J., Crowe, C.S., Massenburg, B.B., Morrison, S.D., Acebedo, A., Adelson, J.D., Agesa, K.M., Alam, T., Albertson, S.B., Anderson, J.A., Antony, C.M., Ashbaugh, C., Assmus, M., Azhar, G., Balassyano, S., Bannick, M.S., Barthelemy, C.M., Bender, R.G., Bennitt, F.B., Bertolacci, G.J., Biehl, M.H., Bisignano, C., Boon-Dooley, A.S., Briant, P.S., Bryazka, D., Bumgarner, B.R., Callender, C.S., Cao, J., Castle, C.D., Castro, E., Causey, K., Cercy, K.M., Chalek, J., Charlson, F.J., Cohen, A.J., Comfort, H., Compton, K., Croneberger, A.J., Cruz, J.A., Cunningham, M., Dandona, R., Dangel, W.J., Dean, F.E., DeCleene, N.K., Deen, A., Degenhardt, L., Dingels, Z.V., Dippenaar, I.N., Dirac, M.A., Dolgert, A.J., Emmons-Bell, S., Estep, K., Farag, T., Feigin, V.L., Feldman, R., Ferrara, G., Ferrari, A.J., Fitzgerald, R., Force, L.M., Fox, J.T., Frank, T.D., Fu, W., Fukutaki, K., Fuller, J.E., Fullman, N., Galles, N.C., Gardner, W.M., Gershberg Hayoon, A., Goren, E., Gorman, T.M., Gottlich, H.C., Guo, G., Haddock, B., Hagins, H., Haile, L.M., Hamilton, E.B., Han, C., Han, H., Harvey, J.D., Henny, K., Henrikson, H.J., Henry, N.J., Herbert, M.E., Hsiao, T., Huynh, C.K., Iannucci, V.C., Ippolito, H., Irvine, C.M.S., Jafari, H., Jahagirdar, D., James, S.L., Johnson, C.O., Johnson, S.C., Keller, C., Kemmer, L., Kendrick, P.J., Knight, M., Kocarnik, J.M., Krohn, K.J., Larson, S.L., Lau, K.M., Ledesma, J.R., Leever, A.T., LeGrand, K.E., Lescinsky, H., Lin, C., Liu, H., Liu, Z., Lo, J., Lu, A., Ma, J., Maddison, E.R., Manguerra, H., Marks, A., Martopullo, I., Mastrogiacomo, C.I., May, E.A., Mooney, M.D., Mosser, J.F., Mullany, E.C., Mumford, J., Munro, S.B., Nandakumar, V., Nguyen, J., Nguyen, M., Nichols, E., Nixon, M.R., Odell, C.M., Ong, K.L., Orji, A.U., Ostroff, S.M., Pasovic, M., Paulson, K.R., Pease, S.A., Pennini, A., Pierce, M., Pilz, T.M., Pletcher, M., Rao, P.C., Razo, C., Redford, S.B., Reinig, N., Reitsma, M.B., Rhinehart, P., Robalik, T., Roberts, S., Roberts, N.L.S., Rolfe, S., Sbarra, A.N., Schaeffer, L.E., Shackelford, K.A., Shadid, J., Sharara, F., Shaw, D.H., Sheena, B.S., Simpson, K.E., Smith, A., Spencer, C.N., Spurlock, E.E., Stark, B.A., Steiner, C., Steuben, K.M., Sylte, D.O., Tang, M., Taylor, H.J., Terrason, S., Thomson, A.M., Torre, A.E., Travillian, R., Troeger, C.E., Vongpradith, A., Walters, M.K., Wang, J., Watson, A., Watson, S., Whisnant, J.L., Whiteford, H.A., Wiens, K.E., Wilner, L.B., Wilson, S., Wool, E.E., Wozniak, S.S., Wu, J., Wulf Hanson, S., Wunrow, H., Xu, R., Yadgir, S., Yearwood, J.A., York, H.W., Yuan, C., Zhao, J.T., Zheng, P., Zimsen, S.R.M., Zlavog, B.S., Chang, A.Y., Oren, E., Buchbinder, R., Chin, K.L., Guo, Y., Polkinghorne, K.R., Thrift, A.G., Lee, S.W.H., Ackerman, I.N., Cicuttini, F.M., Li, S., Zaman, S., Suleria, H., Zhang, J., Cowie, B.C., Wijeratne, 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Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Komaki, Hamidreza, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krohn, Kris J, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lami, Faris Hasan, Lansky, Sonia, Larson, Samantha Leigh, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lazarus, Jeffrey V, Lee, Paul H, Lee, Shaun Wen Huey, Leever, Andrew T, Legrand, Kate E, Leonardi, Matilde, Li, Shanshan, Lim, Lee-Ling, Lim, Stephen S, Linn, Shai, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lopukhov, Platon D, Lotufo, Paulo A, Lozano, Rafael, Lu, Alton, Lunevicius, Raimunda, Madadin, Mohammed, Maddison, Emilie R, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Malekzadeh, Reza, Mamun, Abdullah A, Manafi, Navid, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Mastrogiacomo, Claudia I, Mathur, Manu Raj, May, Erin A, Mcalinden, Colm, Mcgrath, John J, Mckee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Meitei, Wahengbam Bigyananda, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R, Mills, Edward J, Milne, George J, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Dara K, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Hussen, Mohammed, Shafiu, Mohebi, Farnam, Mohseni Bandpei, Mohammad A, Mokari, Amin, Mokdad, Ali H, Momen, Natalie C, Monasta, Lorenzo, Mooney, Meghan D, Moradi, Ghobad, Moradi, Masoud, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Moreno Velásquez, Ilai, Morgado-da-Costa, Joana, Morrison, Shane Dougla, Mosser, Jonathan F, Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Musa, Kamarul Imran, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Nigatu, Yeshambel T, Nikbakhsh, Rajan, Nikpoor, Amin Reza, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Noubiap, Jean Jacque, Nouraei Motlagh, Soraya, Nowak, Christoph, Oţoiu, Adrian, Odell, Christopher M, Oh, In-Hwan, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar Bali, Ahmed, Ong, Kanyin L, Onwujekwe, Obinna E, Ortiz, Alberto, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Park, Jame, Pasupula, Deepak Kumar, Patel, Jenil R, Patel, Sangram Kishor, Patton, George C, Paulson, Katherine R, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, Alexandre, Pereira, David M, Perico, Norberto, Pigott, David M, Pilgrim, Thoma, Pilz, Tessa M, Piradov, Michael A, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Poznańska, Anna, Prada, Sergio I, Prakash, Sanjay, Preotescu, Liliana, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Ram, Pradhum, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawal, Lal, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Nima, Rezai, Mohammad sadegh, Rezapour, Aziz, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostamian, Morteza, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salahshoor, Mohammad Reza, Salama, Joseph S, Salamati, Payman, Salem, Marwa R Rashad, Salimi, Yahya, Salomon, Joshua A, Salz, Inbal, Samad, Zainab, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saylan, Mete, Schaeffer, Lauren E, Schiavolin, Silvia, Schwebel, David C, Schwendicke, Falk, Sekerija, Mario, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Shabani, Mahsima, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharafi, Zeinab, Sharara, Fablina, Sharma, Rajesh, Shaw, David H, Sheikh, Aziz, Shin, Jae Il, Shiri, Rahman, Shrime, Mark G, Shuval, Kerem, Siabani, Soraya, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santo, Simonetti, Biagio, Simpson, Kyle E, Singh, Jasvinder A, Skiadaresi, Eirini, Skryabin, Valentin Yurievich, Soheili, Amin, Sokhan, Anton, Sorensen, Reed J D, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stockfelt, Leo, Stokes, Mark A, Stubbs, Jacob L, Sudaryanto, Agu, Sufiyan, Mu'awiyyah Babale, Suliankatchi Abdulkader, Rizwan, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tadakamadla, Santosh Kumar, Taherkhani, Amir, Tang, Muming, Taveira, Nuno, Taylor, Heather Jean, Teagle, Whitney L, Tehrani-Banihashemi, Arash, Teklehaimanot, Berhane Fseha, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thomas, Nihal, Thrift, Amanda G, Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tovani-Palone, Marcos Roberto Roberto, Traini, Eugenio, Tran, Bach Xuan, Travillian, Ravensara, Trias-Llimós, Sergi, Truelsen, Thomas Clement, Tudor Car, Lorainne, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vakilian, Alireza, Valdez, Pascual R, Valli, Alessandro, Vardavas, Constantine, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogale, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Vidale, Simone, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vujcic, Isidora S, Vukovic, Ana, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Walters, Magdalene K, Wang, Hongbo, Wang, Yuan-Pang, Watson, Stefanie, Wei, Jingkai, Weiss, Jordan, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wiangkham, Taweewat, Wiens, Kirsten E, Wijeratne, Tissa, Wiysonge, Charles Shey, Wojtyniak, Bogdan, Wolfe, Charles D A, Wondmieneh, Adam Belay, Wool, Eve E, Wu, Ai-Min, Wu, Junjie, Xu, Gelin, Yamada, Tomohide, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yearwood, Jamal A, Yeheyis, Tomas Y, Yilgwan, Christopher Sabo, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yoosefi Lebni, Javad, York, Hunter W, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zakzuk, Josefina, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zhang, Zhi-Jiang, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, Murray, Christopher J L, Collaborators, GBD 2019 Demographics, GBD 2019 Demographics Collaborator, Violante FS, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Department of Earth Systems Analysis, Biomechanical Engineering, TechMed Centre, Biomolecular Nanotechnology, Research Methodology, Measurement and Data Analysis, Materials Science and Technology of Polymers, Inorganic Materials Science, MESA+ Institute, Biomedical and Environmental Sensorsystems, Mesoscale Chemical Systems, Faculty of Engineering Technology, Nonlinear Solid Mechanics, Digital Society Institute, Pervasive Systems, Nanobiophysics, Faculty of Geo-Information Science and Earth Observation, Multi Scale Mechanics, Engineering Fluid Dynamics, Physics of Complex Fluids, Developmental BioEngineering, Physics of Fluids, Elastomer Technology and Engineering, Medical Cell Biophysics, European Membrane Institute, Department of Earth Observation Science, Biomaterials Science and Technology, Sustainable Process Technology, Department of Urban and Regional Planning and Geo-Information Management, Department of Natural Resources, XUV Optics, Databases (Former), Department of Water Resources, Psychology, Health & Technology, Membrane Science & Technology, Department of Public Health, Clinicum, HUS Neurocenter, HUS Comprehensive Cancer Center, and Environmental Sciences
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Male ,very elderly ,Demographic transition ,HALE ,030204 cardiovascular system & hematology ,preschool child ,Global Burden of Disease ,Carga Global de Enfermedades ,0302 clinical medicine ,newborn ,Risk Factors ,Surveys and Questionnaires ,and Risk Factors Study ,80 and over ,030212 general & internal medicine ,Birth Rate ,Child ,Migration ,11 Medical and Health Sciences ,Aged, 80 and over ,education.field_of_study ,Injuries ,Geography ,Mortality rate ,1. No poverty ,DEATH ,Censuses ,General Medicine ,SDG 10 - Reduced Inequalities ,Middle Aged ,Demographic analysis ,3142 Public health care science, environmental and occupational health ,3. Good health ,demographic analysis ,Estilo de Vida Saludable ,risk factor ,Child, Preschool ,Demography/statistics & numerical data ,Global Burden of Diseases, Injuries, Risk Factors, Fertility, Mortality, Migration, Population ,epidemiology ,Female ,A990 Medicine and Dentistry not elsewhere classified ,CHILD-MORTALITY ,Live Birth ,Global Health Metrics ,TRANSITION ,demographics ,GBD ,fertility ,mortality ,hale ,Adult ,Adolescent ,Total fertility rate ,Population ,Global Burden of Diseases, Injuries, and Risk Factors Study ,Birth rate ,03 medical and health sciences ,Young Adult ,Life Expectancy ,SDG 3 - Good Health and Well-being ,General & Internal Medicine ,SYSTEMATIC ANALYSIS ,Demografía ,Humans ,Global Burden of Disease Study ,human ,Mortality ,education ,Preschool ,Aged ,Demography ,Spatial Analysis ,questionnaire ,Infant, Newborn ,Klinisk medicin ,HIV ,Infant ,Global Burden of Diseases ,sex-specific fertility ,Live Birth/epidemiology ,purl.org/pe-repo/ocde/ford#3.02.00 [https] ,MODEL ,Fertilidad ,Fertility ,Demographic change ,Life expectancy ,NA ,global disease burden ,Clinical Medicine ,population research - Abstract
Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.
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- 2020
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39. Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
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Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J, Dickson DW, Dugger BN, Ervin JF, Fleming J, Graff-Radford J, Grinberg LT, Hokkanen SRK, Hunter S, Kapasi A, Kawas CH, Keage HAD, Keene CD, Kero M, Knopman DS, Kouri N, Kovacs GG, Labuzan SA, Larson EB, Latimer CS, Leite REP, Matchett BJ, Matthews FE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Nelson RS, Neltner JH, Nguyen AT, Petersen RC, Polvikoski T, Reichard RR, Rodriguez RD, Suemoto CK, Wang SJ, Wharton SB, White L, Schneider JA
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- 2022
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40. Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study
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Nichols E, Abd-Allah F, Abdoli A, Abualhasan A, Abu-Gharbieh E, Afshin A, Akinyemi R, Alanezi F, Alipour V, Almasi-Hashiani A, Arabloo J, Ashraf-Ganjouei A, Ayano G, Ayuso-Mateos J, Baig A, Banach M, Barboza M, Barker-Collo S, Baune B, Bhagavathula A, Bhattacharyya K, Bijani A, Biswas A, Boloor A, Brayne C, Brenner H, Burkart K, Nagaraja S, Carvalho F, Castro-de-Araujo L, Catala-Lopez F, Cerin E, Cherbuin N, Chu D, Dai X, De Sa A, Djalalinia S, Douiri A, Edvardsson D, El-Jaafary S, Eskandarieh S, Faro A, Farzadfar F, Feigin V, Fereshtehnejad S, Fernandes E, Ferrara P, Filip I, Fischer F, Gaidhane S, Galluzzo L, Gebremeskel G, Ghashghaee A, Gialluisi A, Gnedovskaya E, Golechha M, Gupta R, Hachinski V, Haider M, Haile T, Hamiduzzaman M, Hankey G, Hay S, Heidari G, Heidari-Soureshjani R, Ho H, Househ M, Hwang B, Iacoviello L, Ilesanmi O, Ilic I, Ilic M, Irvani S, Iwagami M, Iyamu I, Jha R, Kalani R, Karch A, Kasa A, Khader Y, Khan E, Khatib M, Kim Y, Kisa S, Kisa A, Kivimaki M, Koyanagi A, Kumar M, Landires I, Lasrado S, Li B, Lim S, Liu X, Kunjathur S, Majeed A, Malik P, Mehndiratta M, Menezes R, Mohammad Y, Mohammed S, Mokdad A, Moni M, Nagel G, Naveed M, Nayak V, Nguyen C, Nguyen H, Nunez-Samudio V, Olagunju A, Ostroff S, Otstavnov N, Owolabi M, Kan F, Patel U, Phillips M, Piradov M, Pond C, Pottoo F, Prada S, Radfar A, Rahim F, Rana J, Rashedi V, Rawaf S, Rawaf D, Reinig N, Renzaho A, Rezaei N, Rezapour A, Romoli M, Roshandel G, Sachdev P, Sahebkar A, Sahraian M, Samaei M, Saylan M, Sha F, Shaikh M, Shibuya K, Shigematsu M, Shin J, Shiri R, Silva D, Singh J, Singhal D, Skryabin V, Skryabina A, Soheili A, Sotoudeh H, Spurlock E, Szoeke C, Tabares-Seisdedos R, Taddele B, Tovani-Palone M, Tsegaye G, Vacante M, Venketasubramanian N, Vidale S, Vlassov V, Vu G, Wang Y, Weiss J, Weldemariam A, Westerman R, Wimo A, Winkler A, Wu C, Yadollahpour A, Yesiltepe M, Yonemoto N, Yu C, Zastrozhin M, Zastrozhina A, Zhang Z, Murray C, Vos T, Apollo - University of Cambridge Repository, Nichols, E, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Afshin, A, Akinyemi, R, Alanezi, F, Alipour, V, Almasi-Hashiani, A, Arabloo, J, Ashraf-Ganjouei, A, Ayano, G, Ayuso-Mateos, J, Baig, A, Banach, M, Barboza, M, Barker-Collo, S, Baune, B, Bhagavathula, A, Bhattacharyya, K, Bijani, A, Biswas, A, Boloor, A, Brayne, C, Brenner, H, Burkart, K, Burugina Nagaraja, S, Carvalho, F, Castro-de-Araujo, L, Catala-Lopez, F, Cerin, E, Cherbuin, N, Chu, D, Dai, X, de Sa-Junior, A, Djalalinia, S, Douiri, A, Edvardsson, D, El-Jaafary, S, Eskandarieh, S, Faro, A, Farzadfar, F, Feigin, V, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fischer, F, Gaidhane, S, Galluzzo, L, Gebremeskel, G, Ghashghaee, A, Gialluisi, A, Gnedovskaya, E, Golechha, M, Gupta, R, Hachinski, V, Haider, M, Haile, T, Hamiduzzaman, M, Hankey, G, Hay, S, Heidari, G, Heidari-Soureshjani, R, Ho, H, Househ, M, Hwang, B, Iacoviello, L, Ilesanmi, O, Ilic, I, Ilic, M, Irvani, S, Iwagami, M, Iyamu, I, Jha, R, Kalani, R, Karch, A, Kasa, A, Khader, Y, Khan, E, Khatib, M, Kim, Y, Kisa, S, Kisa, A, Kivimaki, M, Koyanagi, A, Kumar, M, Landires, I, Lasrado, S, Li, B, Lim, S, Liu, X, Madhava Kunjathur, S, Majeed, A, Malik, P, Mehndiratta, M, Menezes, R, Mohammad, Y, Mohammed, S, Mokdad, A, Moni, M, Nagel, G, Naveed, M, Nayak, V, Nguyen, C, Nguyen, H, Nunez-Samudio, V, Olagunju, A, Ostroff, S, Otstavnov, N, Owolabi, M, Pashazadeh Kan, F, Patel, U, Phillips, M, Piradov, M, Pond, C, Pottoo, F, Prada, S, Radfar, A, Rahim, F, Rana, J, Rashedi, V, Rawaf, S, Rawaf, D, Reinig, N, Renzaho, A, Rezaei, N, Rezapour, A, Romoli, M, Roshandel, G, Sachdev, P, Sahebkar, A, Sahraian, M, Samaei, M, Saylan, M, Sha, F, Shaikh, M, Shibuya, K, Shigematsu, M, Shin, J, Shiri, R, Silva, D, Singh, J, Singhal, D, Skryabin, V, Skryabina, A, Soheili, A, Sotoudeh, H, Spurlock, E, Szoeke, C, Tabares-Seisdedos, R, Taddele, B, Tovani-Palone, M, Tsegaye, G, Vacante, M, Venketasubramanian, N, Vidale, S, Vlassov, V, Vu, G, Wang, Y, Weiss, J, Weldemariam, A, Westerman, R, Wimo, A, Winkler, A, Wu, C, Yadollahpour, A, Yesiltepe, M, Yonemoto, N, Yu, C, Zastrozhin, M, Zastrozhina, A, Zhang, Z, Murray, C, and Vos, T
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Gerontology ,Male ,Computer applications to medicine. Medical informatics ,Population Dynamics ,R858-859.7 ,Global health ,Health Informatics ,Sample (statistics) ,MINI-MENTAL-STATE ,Logistic regression ,DISEASE ,Validity ,Item response theory ,GBD 2019 Dementia Collaborators ,medicine ,Prevalence ,Dementia ,Humans ,Neuropsychological assessment ,Longitudinal Studies ,Aged, 80 and over ,Retirement ,Science & Technology ,medicine.diagnostic_test ,Health Policy ,1103 Clinical Sciences ,Cognition ,NEUROPSYCHOLOGICAL ASSESSMENT ,medicine.disease ,Computer Science Applications ,Cognitive test ,Algorithm ,0806 Information Systems ,Female ,Psychology ,Life Sciences & Biomedicine ,Medical Informatics ,Algorithms ,Research Article - Abstract
BackgroundData sparsity is a major limitation to estimating national and global dementia burden. Surveys with full diagnostic evaluations of dementia prevalence are prohibitively resource-intensive in many settings. However, validation samples from nationally representative surveys allow for the development of algorithms for the prediction of dementia prevalence nationally.MethodsUsing cognitive testing data and data on functional limitations from Wave A (2001–2003) of the ADAMS study (n = 744) and the 2000 wave of the HRS study (n = 6358) we estimated a two-dimensional item response theory model to calculate cognition and function scores for all individuals over 70. Based on diagnostic information from the formal clinical adjudication in ADAMS, we fit a logistic regression model for the classification of dementia status using cognition and function scores and applied this algorithm to the full HRS sample to calculate dementia prevalence by age and sex.ResultsOur algorithm had a cross-validated predictive accuracy of 88% (86–90), and an area under the curve of 0.97 (0.97–0.98) in ADAMS. Prevalence was higher in females than males and increased over age, with a prevalence of 4% (3–4) in individuals 70–79, 11% (9–12) in individuals 80–89 years old, and 28% (22–35) in those 90 and older.ConclusionsOur model had similar or better accuracy as compared to previously reviewed algorithms for the prediction of dementia prevalence in HRS, while utilizing more flexible methods. These methods could be more easily generalized and utilized to estimate dementia prevalence in other national surveys.
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- 2021
41. A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD)
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Proitsi, P., Hamilton, G., Tsolaki, M., Lupton, M., Daniilidou, M., Hollingworth, P., Archer, N., Foy, C., Stylios, F., McGuinness, B., Todd, S., Lawlor, B., Gill, M., Brayne, C., Rubinsztein, D.C., Owen, M., Williams, J., Craig, D., Passmore, P., Lovestone, S., and Powell, J.F.
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- 2011
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42. Visual impairment and risk of dementia in two population-based prospective cohorts: UK Biobank and EPIC-Norfolk
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Littlejohns, T, Hayat, S, Luben, R, Brayne, C, Conroy, M, Foster, PJ, Khawaja, AP, and Kuźma, E
- Abstract
Visual impairment has emerged as a potential modifiable risk factor for dementia. However, there are a lack of large studies with objective measures of vison and with more than ten years of follow-up. We investigated whether visual impairment is associated with an increased risk of incident dementia in UK Biobank and EPIC-Norfolk. In both cohorts, visual acuity was measured using a “logarithm of the minimum angle of resolution” (LogMAR) chart and categorised as no (≤0.30 LogMAR), mild (>0.3 - ≤0.50 LogMAR), and moderate to severe (>0.50 LogMAR) impairment. Dementia was ascertained through linkage to electronic medical records. After restricting to those aged ≥60 years, without prevalent dementia and with eye measures available, the analytic samples consisted of 62,206 UK Biobank and 7,337 EPIC-Norfolk participants, respectively. In UK Biobank and EPIC-Norfolk. respectively, 1,113 and 517 participants developed dementia over 11 and 15 years of follow-up. Using multivariable cox proportional-hazards models, the hazard ratios for mild and moderate to severe visual impairment were 1.26 (95% Confidence Interval [CI] 0.92-1.72) and 2.16 (95% CI 1.37-3.40), in UK Biobank, and 1.05 (95% CI 0.72-1.53) and 1.93 (95% CI 1.05-3.56) in EPIC-Norfolk, compared to no visual impairment. When excluding participants censored within 5 years of follow-up or with prevalent poor or fair self-reported health, the direction of the associations remained similar for moderate impairment but were not statistically significant. Our findings suggest visual impairment might be a promising target for dementia prevention, however the possibility of reverse causation cannot be excluded.
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- 2021
43. Dementia in the older population is associated with neocortex content of serum amyloid P component
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Ellmerich, S., Taylor, G.W., Richardson, C.D., Minett, T., Schmidt, A.F., Brayne, C., Matthews, F.E., Ince, P.G., Wharton, S.B., and Pepys, M.B.
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mental disorders - Abstract
Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer’s disease and some other common dementias is not known. The normal human plasma protein, serum amyloid P component, a constituent of all human fibrillar amyloid deposits and present on most neurofibrillary tangles, is cytotoxic for cerebral neurones in vitro and in experimental animals in vivo. The neocortical content of serum amyloid P component was immunoassayed in 157 subjects aged 65 or more with known dementia status at death, in the large scale, population-representative, brain donor cohort of the Cognitive Function and Ageing Study, which avoids the biases inherent in studies of predefined clinico-pathological groups. The serum amyloid P component values were significantly higher in individuals with dementia, independent of serum albumin content measured as a control for plasma in the cortex samples. The odds ratio for dementia at death in the high serum amyloid P component tertile was 5.24 (95% confidence interval 1.79–15.29) and was independent of Braak tangle stages and Thal amyloid-β phases of neuropathological severity. The strong and specific association of higher brain content of serum amyloid P component with dementia, independent of neuropathology, is consistent with a pathogenetic role in dementia.
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- 2021
44. Conversion to dementia in mild cognitive impairment diagnosed with DSM-5 criteria and with Petersenʼs criteria
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Marcos, G., Santabárbara, J., Lopez-Anton, R., De-la-Cámara, C., Gracia-García, P., Lobo, E., Pírez, G., Menchón, J. M., Palomo, T., Stephan, B. C. M., Brayne, C., and Lobo, A.
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- 2016
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45. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
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Simpson, J.E., Ince, P.G., Lace, G., Forster, G., Shaw, P.J., Matthews, F., Savva, G., Brayne, C., and Wharton, S.B.
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- 2010
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46. Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 2016
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Feigin V, Nichols E, Alam T, Bannick M, Beghi E, Blake N, Culpepper W, Dorsey E, Elbaz A, Ellenbogen R, Fisher J, Fitzmaurice C, Giussani G, Glennie L, James S, Johnson C, Kassebaum N, Logroscino G, Marin B, Mountjoy-Venning W, Nguyen M, Ofori-Asenso R, Patel A, Piccininni M, Roth G, Steiner T, Stovner L, Szoeke C, Theadom A, Vollset S, Wallin M, Wright C, Zunt J, Abbasi N, Abd-Allah F, Abdelalim A, Abdollahpour I, Aboyans V, Abraha H, Acharya D, Adamu A, Adebayo O, Adeoye A, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Al-Eyadhy A, Salman R, Alahdab F, Alene K, Aljunid S, Altirkawi K, Alvis-Guzman N, Anber N, Antonio C, Arabloo J, Aremu O, Arnlov J, Asayesh H, Asghar R, Atalay H, Awasthi A, Quintanilla B, Ayuk T, Badawi A, Banach M, Banoub J, Barboza M, Barker-Collo S, Barnighausen T, Baune B, Bedi N, Behzadifar M, Bejot Y, Bekele B, Belachew A, Bennett D, Bensenor I, Berhane A, Beuran M, Bhattacharyya K, Bhutta Z, Biadgo B, Bijani A, Bililign N, Bin Sayeed M, Blazes C, Brayne C, Butt Z, Campos-Nonato I, Cantu-Brito C, Car M, Cardenas R, Carrero J, Carvalho F, Castaneda-Orjuela C, Castro F, Catala-Lopez F, Cerin E, Chaiah Y, Chang J, Chatziralli I, Chiang P, Christensen H, Christopher D, Cooper C, Cortesi P, Costa V, Criqui M, Crowe C, Damasceno A, Daryani A, De la Cruz-Gongora V, De la Hoz F, De Leo D, Degefa M, Demoz G, Deribe K, Dharmaratne S, Diaz D, Dinberu M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edvardsson D, El-Khatib Z, Endres M, Endries A, Eskandarieh S, Esteghamati A, Esteghamati S, Farhadi F, Faro A, Farzadfar F, Farzaei M, Fatima B, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Garcia-Gordillo M, Gebre A, Gebremichael T, Gelaw B, Geleijnse J, Geremew D, Gezae K, Ghasemi-Kasman M, Gidey M, Gill P, Gill T, Gnedovskaya E, Goulart A, Grada A, Grosso G, Guo Y, Gupta R, Haagsma J, Hagos T, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Hao Y, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hay S, Hegazy M, Heidari B, Henok A, Heydarpour F, Hoang C, Hole M, Rad E, Hosseini S, Hu G, Igumbor E, Ilesanmi O, Irvani S, Islam S, Jakovljevic M, Javanbakht M, Jha R, Jobanputra Y, Jonas J, Jozwiak J, Jurisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karami M, Karch A, Karimi N, Kasaeian A, Kassa T, Kassa Z, Kaul A, Kefale A, Keiyoro P, Khader Y, Khafaie M, Khalil I, Khan E, Khang Y, Khazaie H, Kiadaliri A, Kiirithio D, Kim A, Kim D, Kim Y, Kisa A, Kokubo Y, Koyanagi A, Krishnamurthi R, Defo B, Bicer B, Kumar M, Lacey B, Lafranconi A, Lansingh V, Latifi A, Leshargie C, Li S, Liao Y, Linn S, Lo W, Lopez J, Lorkowski S, Lotufo P, Lucas R, Lunevicius R, Mackay M, Mahotra N, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malta D, Manafi N, Mansournia M, Mantovani L, Marz W, Mashamba-Thompson T, Massenburg B, Mate K, McAlinden C, McGrath J, Mehta V, Meier T, Meles H, Melese A, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirrakhimov E, Moazen B, Mohajer B, Mezerji N, Mohammadi M, Mohammadi-Khanaposhtani M, Mohammadibakhsh R, Mohammadnia-Afrouzi M, Mohammed S, Mohebi F, Mokdad A, Monasta L, Mondello S, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Moradinazar M, Moraga P, Velasquez I, Morrison S, Mousavi S, Muhammed O, Muruet W, Musa K, Mustafa G, Naderi M, Nagel G, Naheed A, Naik G, Najafi F, Nangia V, Negoi I, Negoi R, Newton C, Ngunjiri J, Nguyen C, Nguyen L, Ningrum D, Nirayo Y, Nixon M, Norrving B, Noubiap J, Shiadeh M, Nyasulu P, Ogbo F, Oh I, Olagunju A, Olagunju T, Olivares P, Onwujekwe O, Oren E, Owolabi M, Mahesh P, Pakpour A, Pan W, Panda-Jonas S, Pandian J, Patel S, Pereira D, Petzold M, Pillay J, Piradov M, Polanczyk G, Polinder S, Postma M, Poulton R, Poustchi H, Prakash S, Prakash V, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rajati F, Ram U, Ranta A, Rawaf D, Rawaf S, Reinig N, Reis C, Renzaho A, Resnikoff S, Rezaeian S, Rezai M, Gonzalez C, Roberts N, Roever L, Ronfani L, Roro E, Roshandel G, Rostami A, Sabbagh P, Sacco R, Sachdev P, Saddik B, Safari H, Safari-Faramani R, Safi S, Safiri S, Sagar R, Sahathevan R, Sahebkar A, Sahraian M, Salamati P, Zahabi S, Salimi Y, Samy A, Sanabria J, Santos I, Milicevic M, Sarrafzadegan N, Sartorius B, Sarvi S, Sathian B, Satpathy M, Sawant A, Sawhney M, Schneider I, Schottker B, Schwebel D, Seedat S, Sepanlou S, Shabaninejad H, Shafieesabet A, Shaikh M, Shakir R, Shams-Beyranvand M, Shamsizadeh M, Sharif M, Sharif-Alhoseini M, She J, Sheikh A, Sheth K, Shigematsu M, Shiri R, Shirkoohi R, Shiue I, Siabani S, Siddiqi T, Sigfusdottir I, Sigurvinsdottir R, Silberberg D, Silva J, Silveira D, Singh J, Sinha D, Skiadaresi E, Smith M, Sobaih B, Sobhani S, Soofi M, Soyiri I, Sposato L, Stein D, Stein M, Stokes M, Sufiyan M, Sykes B, Sylaja P, Tabares-Seisdedos R, Ao B, Tehrani-Banihashemi A, Temsah M, Temsah O, Thakur J, Thrift A, Topor-Madry R, Tortajada-Girbes M, Tovani-Palone M, Tran B, Tran K, Truelsen T, Tsadik A, Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Vasanthan R, Veisani Y, Venketasubramanian N, Violante F, Vlassov V, Vosoughi K, Vu G, Vujcic I, Wagnew F, Waheed Y, Wang Y, Weiderpass E, Weiss J, Whiteford H, Wijeratne T, Winkler A, Wiysonge C, Wolfe C, Xu G, Yadollahpour A, Yamada T, Yano Y, Yaseri M, Yatsuya H, Yimer E, Yip P, Yisma E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Bin Zaman S, Zamani M, Zandian H, Zare Z, Zhang Y, Zodpey S, Naghavi M, Murray C, Vos T, GBD 2016 Neurology Collaborators, Bill & Melinda Gates Foundation, VU University medical center, Feigin V.L., Nichols E., Alam T., Bannick M.S., Beghi E., Blake N., Culpepper W.J., Dorsey E.R., Elbaz A., Ellenbogen R.G., Fisher J.L., Fitzmaurice C., Giussani G., Glennie L., James S.L., Johnson C.O., Kassebaum N.J., Logroscino G., Marin B., Mountjoy-Venning W.C., Nguyen M., Ofori-Asenso R., Patel A.P., Piccininni M., Roth G.A., Steiner T.J., Stovner L.J., Szoeke C.E.I., Theadom A., Vollset S.E., Wallin M.T., Wright C., Zunt J.R., Abbasi N., Abd-Allah F., Abdelalim A., Abdollahpour I., Aboyans V., Abraha H.N., Acharya D., Adamu A.A., Adebayo O.M., Adeoye A.M., Adsuar J.C., Afarideh M., Agrawal S., Ahmadi A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Akinyemi R.O., Akseer N., Al-Eyadhy A., Al-Shahi Salman R., Alahdab F., Alene K.A., Aljunid S.M., Altirkawi K., Alvis-Guzman N., Anber N.H., Antonio C.A.T., Arabloo J., Aremu O., Arnlov J., Asayesh H., Asghar R.J., Atalay H.T., Awasthi A., Ayala Quintanilla B.P., Ayuk T.B., Badawi A., Banach M., Banoub J.A.M., Barboza M.A., Barker-Collo S.L., Barnighausen T.W., Baune B.T., Bedi N., Behzadifar M., Bejot Y., Bekele B.B., Belachew A.B., Bennett D.A., Bensenor I.M., Berhane A., Beuran M., Bhattacharyya K., Bhutta Z.A., Biadgo B., Bijani A., Bililign N., Bin Sayeed M.S., Blazes C.K., Brayne C., Butt Z.A., 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Guo Y., Gupta R., Haagsma J.A., Hagos T.B., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Hankey G.J., Hao Y., Haro J.M., Hassankhani H., Hassen H.Y., Havmoeller R., Hay S.I., Hegazy M.I., Heidari B., Henok A., Heydarpour F., Hoang C.L., Hole M.K., Homaie Rad E., Hosseini S.M., Hu G., Igumbor E.U., Ilesanmi O.S., Irvani S.S.N., Islam S.M.S., Jakovljevic M., Javanbakht M., Jha R.P., Jobanputra Y.B., Jonas J.B., Jozwiak J.J., Jurisson M., Kahsay A., Kalani R., Kalkonde Y., Kamil T.A., Kanchan T., Karami M., Karch A., Karimi N., Kasaeian A., Kassa T.D., Kassa Z.Y., Kaul A., Kefale A.T., Keiyoro P.N., Khader Y.S., Khafaie M.A., Khalil I.A., Khan E.A., Khang Y.-H., Khazaie H., Kiadaliri A.A., Kiirithio D.N., Kim A.S., Kim D., Kim Y.-E., Kim Y.J., Kisa A., Kokubo Y., Koyanagi A., Krishnamurthi R.V., Kuate Defo B., Kucuk Bicer B., Kumar M., Lacey B., Lafranconi A., Lansingh V.C., Latifi A., Leshargie C.T., Li S., Liao Y., Linn S., Lo W.D., Lopez J.C.F., Lorkowski S., Lotufo P.A., Lucas R.M., Lunevicius R., Mackay M.T., Mahotra N.B., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malta D.C., Manafi N., Mansournia M.A., Mantovani L.G., Marz W., Mashamba-Thompson T.P., Massenburg B.B., Mate K.K.V., McAlinden C., McGrath J.J., Mehta V., Meier T., Meles H.G., Melese A., Memiah P.T.N., Memish Z.A., Mendoza W., Mengistu D.T., Mengistu G., Meretoja A., Meretoja T.J., Mestrovic T., Miazgowski B., Miazgowski T., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohajer B., Mohammad Gholi Mezerji N., Mohammadi M., Mohammadi-Khanaposhtani M., Mohammadibakhsh R., Mohammadnia-Afrouzi M., Mohammed S., Mohebi F., Mokdad A.H., Monasta L., Mondello S., Moodley Y., Moosazadeh M., Moradi G., Moradi-Lakeh M., Moradinazar M., Moraga P., Moreno Velasquez I., Morrison S.D., Mousavi S.M., Muhammed O.S., Muruet W., Musa K.I., Mustafa G., Naderi M., Nagel G., Naheed A., Naik G., Najafi F., Nangia V., Negoi I., Negoi R.I., Newton C.R.J., Ngunjiri J.W., Nguyen C.T., Nguyen L.H., Ningrum D.N.A., Nirayo Y.L., Nixon M.R., Norrving B., Noubiap J.J., Nourollahpour Shiadeh M., Nyasulu P.S., Ogbo F.A., Oh I.-H., Olagunju A.T., Olagunju T.O., Olivares P.R., Onwujekwe O.E., Oren E., Owolabi M.O., A M.P., Pakpour A.H., Pan W.-H., Panda-Jonas S., Pandian J.D., Patel S.K., Pereira D.M., Petzold M., Pillay J.D., Piradov M.A., Polanczyk G.V., Polinder S., Postma M.J., Poulton R., Poustchi H., Prakash S., Prakash V., Qorbani M., Radfar A., Rafay A., Rafiei A., Rahim F., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rahman M.A., Rajati F., Ram U., Ranta A., Rawaf D.L., Rawaf S., Reinig N., Reis C., Renzaho A.M.N., Resnikoff S., Rezaeian S., Rezai M.S., Rios Gonzalez C.M., Roberts N.L.S., Roever L., Ronfani L., Roro E.M., Roshandel G., Rostami A., Sabbagh P., Sacco R.L., Sachdev P.S., Saddik B., Safari H., Safari-Faramani R., Safi S., Safiri S., Sagar R., Sahathevan R., Sahebkar A., Sahraian M.A., Salamati P., Salehi Zahabi S., Salimi Y., Samy A.M., Sanabria J., Santos I.S., Santric Milicevic M.M., Sarrafzadegan N., Sartorius B., Sarvi S., Sathian B., Satpathy M., Sawant A.R., Sawhney M., Schneider I.J.C., Schottker B., Schwebel D.C., Seedat S., Sepanlou S.G., Shabaninejad H., Shafieesabet A., Shaikh M.A., Shakir R.A., Shams-Beyranvand M., Shamsizadeh M., Sharif M., Sharif-Alhoseini M., She J., Sheikh A., Sheth K.N., Shigematsu M., Shiri R., Shirkoohi R., Shiue I., Siabani S., Siddiqi T.J., Sigfusdottir I.D., Sigurvinsdottir R., Silberberg D.H., Silva J.P., Silveira D.G.A., Singh J.A., Sinha D.N., Skiadaresi E., Smith M., Sobaih B.H., Sobhani S., Soofi M., Soyiri I.N., Sposato L.A., Stein D.J., Stein M.B., Stokes M.A., Sufiyan M.B., Sykes B.L., Sylaja P., Tabares-Seisdedos R., Te Ao B.J., Tehrani-Banihashemi A., Temsah M.-H., Temsah O., Thakur J.S., Thrift A.G., Topor-Madry R., Tortajada-Girbes M., Tovani-Palone M.R., Tran B.X., Tran K.B., Truelsen T.C., Tsadik A.G., Tudor Car L., Ukwaja K.N., Ullah I., Usman M.S., Uthman O.A., Valdez P.R., Vasankari T.J., Vasanthan R., Veisani Y., Venketasubramanian N., Violante F.S., Vlassov V., Vosoughi K., Vu G.T., Vujcic I.S., Wagnew F.S., Waheed Y., Wang Y.-P., Weiderpass E., Weiss J., Whiteford H.A., Wijeratne T., Winkler A.S., Wiysonge C.S., Wolfe C.D.A., Xu G., Yadollahpour A., Yamada T., Yano Y., Yaseri M., Yatsuya H., Yimer E.M., Yip P., Yisma E., Yonemoto N., Yousefifard M., Yu C., Zaidi Z., Zaman S.B., Zamani M., Zandian H., Zare Z., Zhang Y., Zodpey S., Naghavi M., Murray C.J.L., Vos T., Public Health, Feigin, Valery L, Nichols, Emma, Alam, Tahiya, Bannick, Marlena S, Ahmed, Muktar Beshir, Yisma, Engida, Vos, Theo, GBD 2016 Neurology Collaborators, Viðskiptadeild (HR), School of Business (RU), Háskólinn í Reykjavík, Reykjavik University, Feigin, V, Nichols, E, Alam, T, Bannick, M, Beghi, E, Blake, N, Culpepper, W, Dorsey, E, Elbaz, A, Ellenbogen, R, Fisher, J, Fitzmaurice, C, Giussani, G, Glennie, L, James, S, Johnson, C, Kassebaum, N, Logroscino, G, Marin, B, Mountjoy-Venning, W, Nguyen, M, Ofori-Asenso, R, Patel, A, Piccininni, M, Roth, G, Steiner, T, Stovner, L, Szoeke, C, Theadom, A, Vollset, S, Wallin, M, Wright, C, Zunt, J, Abbasi, N, Abd-Allah, F, Abdelalim, A, Abdollahpour, I, Aboyans, V, Abraha, H, Acharya, D, Adamu, A, Adebayo, O, Adeoye, A, Adsuar, J, Afarideh, M, Agrawal, S, Ahmadi, A, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Akseer, N, Al-Eyadhy, A, Al-Shahi Salman, R, Alahdab, F, Alene, K, Aljunid, S, Altirkawi, K, Alvis-Guzman, N, Anber, N, Antonio, C, Arabloo, J, Aremu, O, Ärnlöv, J, Asayesh, H, Asghar, R, Atalay, H, Awasthi, A, Ayala Quintanilla, B, Ayuk, T, Badawi, A, Banach, M, Banoub, J, Barboza, M, Barker-Collo, S, Bärnighausen, T, Baune, B, Bedi, N, Behzadifar, M, Béjot, Y, Bekele, B, Belachew, A, Bennett, D, Bensenor, I, Berhane, A, Beuran, M, Bhattacharyya, K, Bhutta, Z, Biadgo, B, Bijani, A, Bililign, N, Bin Sayeed, M, Blazes, C, Brayne, C, Butt, Z, Campos-Nonato, I, Cantu-Brito, C, Car, M, Cárdenas, R, Carrero, J, Carvalho, F, Castañeda-Orjuela, C, Castro, F, Catalá-López, F, Cerin, E, Chaiah, Y, Chang, J, Chatziralli, I, Chiang, P, Christensen, H, Christopher, D, Cooper, C, Cortesi, P, Costa, V, Criqui, M, Crowe, C, Damasceno, A, Daryani, A, De la Cruz-Góngora, V, De la Hoz, F, De Leo, D, Demoz, G, Deribe, K, Dharmaratne, S, Diaz, D, Dinberu, M, Djalalinia, S, Doku, D, Dubey, M, Dubljanin, E, Duken, E, Edvardsson, D, El-Khatib, Z, Endres, M, Endries, A, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Farhadi, F, Faro, A, Farzadfar, F, Farzaei, M, Fatima, B, Fereshtehnejad, S, Fernandes, E, Feyissa, G, Filip, I, Fischer, F, Fukumoto, T, Ganji, M, Gankpe, F, Garcia-Gordillo, M, Gebre, A, Gebremichael, T, Gelaw, B, Geleijnse, J, Geremew, D, Gezae, K, Ghasemi-Kasman, M, Gidey, M, Gill, P, Gill, T, Girma, E, Gnedovskaya, E, Goulart, A, Grada, A, Grosso, G, Guo, Y, Gupta, R, Haagsma, J, Hagos, T, Haj-Mirzaian, A, Hamadeh, R, Hamidi, S, Hankey, G, Hao, Y, Haro, J, Hassankhani, H, Hassen, H, Havmoeller, R, Hay, S, Hegazy, M, Heidari, B, Henok, A, Heydarpour, F, Hoang, C, Hole, M, Homaie Rad, E, Hosseini, S, Hu, G, Igumbor, E, Ilesanmi, O, Irvani, S, Islam, S, Jakovljevic, M, Javanbakht, M, Jha, R, Jobanputra, Y, Jonas, J, Jozwiak, J, Jürisson, M, Kahsay, A, Kalani, R, Kalkonde, Y, Kamil, T, Kanchan, T, Karami, M, Karch, A, Karimi, N, Kasaeian, A, Kassa, T, Kassa, Z, Kaul, A, Kefale, A, Keiyoro, P, Khader, Y, Khafaie, M, Khalil, I, Khan, E, Khang, Y, Khazaie, H, Kiadaliri, A, Kiirithio, D, Kim, A, Kim, D, Kim, Y, Kisa, A, Kokubo, Y, Koyanagi, A, Krishnamurthi, R, Kuate Defo, B, Kucuk Bicer, B, Kumar, M, Lacey, B, Lafranconi, A, Lansingh, V, Latifi, A, Leshargie, C, Li, S, Liao, Y, Linn, S, Lo, W, Lopez, J, Lorkowski, S, Lotufo, P, Lucas, R, Lunevicius, R, Mackay, M, Mahotra, N, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malta, D, Manafi, N, Mansournia, M, Mantovani, L, März, W, Mashamba-Thompson, T, Massenburg, B, Mate, K, Mcalinden, C, Mcgrath, J, Mehta, V, Meier, T, Meles, H, Melese, A, Memiah, P, Memish, Z, Mendoza, W, Mengistu, D, Mengistu, G, Meretoja, A, Meretoja, T, Mestrovic, T, Miazgowski, B, Miazgowski, T, Miller, T, Mini, G, Mirrakhimov, E, Moazen, B, Mohajer, B, Mohammad Gholi Mezerji, N, Mohammadi, M, Mohammadi-Khanaposhtani, M, Mohammadibakhsh, R, Mohammadnia-Afrouzi, M, Mohammed, S, Mohebi, F, Mokdad, A, Monasta, L, Mondello, S, Moodley, Y, Moosazadeh, M, Moradi, G, Moradi-Lakeh, M, Moradinazar, M, Moraga, P, Moreno Velásquez, I, Morrison, S, Mousavi, S, Muhammed, O, Muruet, W, Musa, K, Mustafa, G, Naderi, M, Nagel, G, Naheed, A, Naik, G, Najafi, F, Nangia, V, Negoi, I, Negoi, R, Newton, C, Ngunjiri, J, Nguyen, C, Nguyen, L, Ningrum, D, Nirayo, Y, Nixon, M, Norrving, B, Noubiap, J, Nourollahpour Shiadeh, M, Nyasulu, P, Ogah, O, Oh, I, Olagunju, A, Olagunju, T, Olivares, P, Onwujekwe, O, Oren, E, Owolabi, M, Pa, M, Pakpour, A, Pan, W, Panda-Jonas, S, Pandian, J, Patel, S, Pereira, D, Petzold, M, Pillay, J, Piradov, M, Polanczyk, G, Polinder, S, Postma, M, Poulton, R, Poustchi, H, Prakash, S, Prakash, V, Qorbani, M, Radfar, A, Rafay, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rajati, F, Ram, U, Ranta, A, Rawaf, D, Rawaf, S, Reinig, N, Reis, C, Renzaho, A, Resnikoff, S, Rezaeian, S, Rezai, M, Rios González, C, Roberts, N, Roever, L, Ronfani, L, Roro, E, Roshandel, G, Rostami, A, Sabbagh, P, Sacco, R, Sachdev, P, Saddik, B, Safari, H, Safari-Faramani, R, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salamati, P, Salehi Zahabi, S, Salimi, Y, Samy, A, Sanabria, J, Santos, I, Santric Milicevic, M, Sarrafzadegan, N, Sartorius, B, Sarvi, S, Sathian, B, Satpathy, M, Sawant, A, Sawhney, M, Schneider, I, Schöttker, B, Schwebel, D, Seedat, S, Sepanlou, S, Shabaninejad, H, Shafieesabet, A, Shaikh, M, Shakir, R, Shams-Beyranvand, M, Shamsizadeh, M, Sharif, M, Sharif-Alhoseini, M, She, J, Sheikh, A, Sheth, K, Shigematsu, M, Shiri, R, Shirkoohi, R, Shiue, I, Siabani, S, Siddiqi, T, Sigfusdottir, I, Sigurvinsdottir, R, Silberberg, D, Silva, J, Silveira, D, Singh, J, Sinha, D, Skiadaresi, E, Smith, M, Sobaih, B, Sobhani, S, Soofi, M, Soyiri, I, Sposato, L, Stein, D, Stein, M, Stokes, M, Sufiyan, M, Sykes, B, Sylaja, P, Tabarés-Seisdedos, R, Te Ao, B, Tehrani-Banihashemi, A, Temsah, M, Temsah, O, Thakur, J, Thrift, A, Topor-Madry, R, Tortajada-Girbés, M, Tovani-Palone, M, Tran, B, Tran, K, Truelsen, T, Tsadik, A, Tudor Car, L, Ukwaja, K, Ullah, I, Usman, M, Uthman, O, Valdez, P, Vasankari, T, Vasanthan, R, Veisani, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Vosoughi, K, Vu, G, Vujcic, I, Wagnew, F, Waheed, Y, Wang, Y, Weiderpass, E, Weiss, J, Whiteford, H, Wijeratne, T, Winkler, A, Wiysonge, C, Wolfe, C, Xu, G, Yadollahpour, A, Yamada, T, Yano, Y, Yaseri, M, Yatsuya, H, Yimer, E, Yip, P, Yisma, E, Yonemoto, N, Yousefifard, M, Yu, C, Zaidi, Z, Zaman, S, Zamani, M, Zandian, H, Zare, Z, Zhang, Y, Zodpey, S, Naghavi, M, Murray, C, Vos, T, PharmacoTherapy, -Epidemiology and -Economics, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Lee Kong Chian School of Medicine (LKCMedicine), Clinicum, Department of Neurosciences, Neurologian yksikkö, Department of Surgery, University of Helsinki, II kirurgian klinikka, and HUS Comprehensive Cancer Center
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Dánarmein ,Male ,Epidemiology ,Diseases ,Malalties cerebrals ,Global Burden of Disease ,Disability Evaluation ,0302 clinical medicine ,Case fatality rate ,Psychology ,Konur ,Cause of death ,Aged, 80 and over ,education.field_of_study ,Incidence ,Men ,Taugavísindi ,ddc ,3. Good health ,Sálfræði ,World health ,Muerte ,Neurology ,GBD 2016 Neurology Collaborators ,Brain diseases ,Quality-Adjusted Life Years ,Alzheimer disease ,Carga global de enfermedades ,Nervous system ,medicine.medical_specialty ,Global burden of diseases ,Lífsgæði ,Article ,03 medical and health sciences ,Health Sciences ,Humans ,Women ,education ,Trastornos neurológicos ,VLAG ,Aged ,Science & Technology ,3112 Neurosciences ,Global Burden of Diseases ,030104 developmental biology ,Years of potential life lost ,Επιστήμες Υγείας ,Dementia ,Human medicine ,Neurosciences & Neurology ,Neurology (clinical) ,Clinical Medicine ,1109 Neurosciences ,Neurological disorders ,030217 neurology & neurosurgery ,dementia ,RC ,0301 basic medicine ,Pediatrics ,Dánartíðni ,Nutrition and Disease ,3124 Neurology and psychiatry ,Disease Study ,Taugasjúkdómar ,Risk Factors ,Voeding en Ziekte ,Cause of Death ,Global health ,Prevalence ,Causes of death ,Public health ,Mortality rate ,Mental Disorders ,Age Factors ,Public Health, Global Health, Social Medicine and Epidemiology ,Middle Aged ,neurologic disease ,Death ,Lýðheilsa ,Female ,Life Sciences & Biomedicine ,Quality of life ,Adult ,Population ,Clinical Neurology ,Sex Factors ,medicine ,Life Science ,Disability-adjusted life year ,Medicine [Science] ,Mortality ,Psychiatry ,Disease burden ,Neurology & Neurosurgery ,burden of neurological disorders ,Faraldsfræði ,business.industry ,Klinisk medicin ,Causes de la mort ,1103 Clinical Sciences ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Socioeconomic Factors ,Karlar ,global disease burden ,Nervous System Diseases ,Cause of death/trends ,business - Abstract
Publisher´s version (útgefin grein)., Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer’s and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer’s disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies., ROA is funded by the National Institutes of Health (U01HG010273). SMA acknowledges the International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia and Department of Health Policy and Management, Faculty of Public Health, Kuwait University for the approval and support to participate in this research project. AAw acknowledges funding support from Department of Science and Technology, Government of India, New Delhi, through INSPIRE Faculty scheme. TBA acknowledges partial funding from the Institute of Medical Research and Medicinal Plant Studies. ABa is supported by the Public Health Agency of Canada. TWB was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor Award, funded by the Federal Ministry of Education and Research. MSBS acknowledges support from the Australian Government Research and Training Program scholarship for a PhD degree at the Australian National University, Australia. JJC is supported by the Swedish Heart and Lung Foundation. FCar is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. EC is supported by an Australian Research Council Future Fellowship (FT3 140100085). KD is supported by a Wellcome Trust [Grant Number 201900] as part of his International Intermediate Fellowship. EF is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. SMSI is funded by the Institute for Physical Activity and Nutrition (IPAN), Deakin University and received funding from High Blood Pressure Research Council of Australia. YKa is a DBT/Wellcome Trust India Alliance Fellow in Public Health. YJK is supported by the Office of Research and Innovation at Xiamen University Malaysia. BL acknowledges funding from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. WDL is supported in part by U10NS086484 NINDS. SLo is funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1411A). RML is supported by a National Health and Medical Research Council (NHMRC) of Australia Senior Research Fellowship. AMa and the Imperial College London are grateful for support from the NW London NIHR Collaboration for Leadership in Applied Health Research and Care. JJM is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the John Cade Fellowship (APP1056929) from NHMRC. TMei acknowledges additional institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Jena-Halle-Leipzig. IMV is supported by the Sistema Nacional de Investigacion (Panama). MOO is supported by SIREN U54 U54HG007479 and SIBS Genomics R01NS107900 grants. AMS was supported by a fellowship from the Egyptian Fulbright Mission Program. MMSM acknowledges the support from the Ministry of Education, Science and Technological Development, Republic of Serbia (contract no 175087). AShe is supported by Health Data Research UK. MBS' work on traumatic brain injury is supported by grants NIH U01 NS086090 (PI G Manley) from the National Institutes of Health (NIH) and DoD W81XWH-14-2-0176 (PI G Manley) from the United States Department of Defense. RTS is supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI17/00719 from ISCIIIFEDER. AGT was supported by a Fellowship from the NHMRC (Australia; 1042600. KBT acknowledges funding supports from the Maurice Wilkins Centre for Biodiscovery, Cancer Society of New Zealand, Health Research Council, Gut Cancer Foundation, and the University of Auckland. CY acknowledges support from the National Natural Science Foundation of China (grant number 81773552) and the Chinese NSFC International Cooperation and Exchange Program (grant number 71661167007)., "Peer Reviewed"
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47. The legacy of the 2013 G8 Dementia Summit: successes, challenges, and potential ways forward-Unsolicited comment
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Brayne, C, Wallace, L, Walsh, S, Brayne, Carol [0000-0001-5307-663X], Walsh, Seb [0000-0001-8894-5006], and Apollo - University of Cambridge Repository
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mental disorders - Abstract
Dementia is a public health and socioeconomic concern that is widely predicted to worsen as the proportion of older adults making up our global population increases.1 By 2050, 152 million people worldwide are expected to experience dementia, along with its associated impact. In an ambitious act to galvanise a global response, the 2013 G8 Dementia Summit was convened with a primary aim to identify a cure or disease-modifying therapy for dementia by 2025.2 New evidence has since deepened our understanding of the potential for disease-modifying therapies, making this target even more unrealistic. In parallel, rapidly accumulating evidence has emphasised the importance of broader societal policies for dementia prevention across the lifecourse.3 Here, we review the goals, progress, and challenges of the Summit activities, and propose potential ways forward to align policy with the public health evidence for dementia prevention.
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48. Psychosocial Aetiology of Chronic Disease: A Pragmatic Approach to the Assessment of Lifetime Affective Morbidity in an EPIC Component Study
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Surtees, P. G., Wainwright, N. W. J., and Brayne, C.
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49. The relationship between back pain and mortality in older adults varies with disability and gender: Results from the Cambridge City over-75s Cohort (CC75C) study
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Docking, R. E., Fleming, J., Brayne, C., Zhao, J., Macfarlane, G. J., and Jones, G. T.
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- 2015
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50. A role for microglia in ageing and dementia: O27
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Boche, D., Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A.R., and CFAS, MRC
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- 2015
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