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2. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

4. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

5. The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies

6. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

7. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

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