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697 results on '"Braunstein, Glenn D."'

1. Myxedema Coma

Author

Donangelo, Ines, Braunstein, Glenn D., Poretsky, Leonid, Series Editor, Loriaux, Lynn, editor, and Vanek, Chaim, editor

Published
2021
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6. Germline PRKACA amplification causes variable phenotypes that may depend on the extent of the genomic defect: molecular mechanisms and clinical presentations

Author

Lodish, Maya B, Yuan, Bo, Levy, Isaac, Braunstein, Glenn D, Lyssikatos, Charalampos, Salpea, Paraskevi, Szarek, Eva, Karageorgiadis, Alexander S, Belyavskaya, Elena, Raygada, Margarita, Faucz, Fabio Rueda, Izzat, Louise, Brain, Caroline, Gardner, James, Quezado, Martha, Carney, J Aidan, Lupski, James R, and Stratakis, Constantine A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric, Human Genome, Clinical Research, Biotechnology, Genetics, 2.1 Biological and endogenous factors, Aetiology, Adrenal Glands, Adrenalectomy, Adult, Child, Child, Preschool, Cushing Syndrome, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, DNA Copy Number Variations, Female, Gene Amplification, Humans, Hyperplasia, Male, Phenotype, Young Adult, Clinical Sciences, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Reproductive medicine
Abstract

ObjectiveWe have recently reported five patients with bilateral adrenocortical hyperplasia (BAH) and Cushing's syndrome (CS) caused by constitutive activation of the catalytic subunit of protein kinase A (PRKACA). By doing new in-depth analysis of their cytogenetic abnormality, we attempted a better genotype-phenotype correlation of their PRKACA amplification.DesignThis study is a case series.MethodsMolecular cytogenetic, genomic, clinical, and histopathological analyses were performed in five patients with CS.ResultsReinvestigation of the defects of previously described patients by state-of-the-art molecular cytogenetics showed complex genomic rearrangements in the chromosome 19p13.2p13.12 locus, resulting in copy number gains encompassing the entire PRKACA gene; three patients (one sporadic case and two related cases) were observed with gains consistent with duplications, while two sporadic patients were observed with gains consistent with triplications. Although all five patients presented with ACTH-independent CS, the three sporadic patients had micronodular BAH and underwent bilateral adrenalectomy in early childhood, whereas the two related patients, a mother and a son, presented with macronodular BAH as adults. In at least one patient, PRKACA triplication was associated with a more severe phenotype.ConclusionsConstitutional chromosomal PRKACA gene amplification is a recently identified genetic defect associated with CS, a trait that may be inherited in an autosomal dominant manner or occur de novo. Genomic rearrangements can be complex and can result in different copy number states of dosage-sensitive genes, e.g., duplication and triplication. PRKACA amplification can lead to variable phenotypes clinically and pathologically, both micro- and macro-nodular BAH, the latter of which we speculate may depend on the extent of amplification.

Published
2015

7. Off-Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

Author

Zhou, Yan, Zhao, Conghui, Gery, Sigal, Braunstein, Glenn D, Okamoto, Ryoko, Alvarez, Rocio, Miles, Steven A, Doan, Ngan B, Said, Jonathan W, Gu, Jiang, and Koeffler, H Phillip

Subjects
Cancer, Aetiology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Animals, Apoptosis, Cell Cycle Checkpoints, Cell Line, Tumor, Cell Proliferation, Crizotinib, Humans, Mice, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-met, Pyrazoles, Pyridines, Pyrrolidinones, Quinolines, Signal Transduction, Thyroid Neoplasms, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis
Abstract

Aberrantly activated c-MET signaling occurs in several cancers, promoting the development of c-MET inhibitors. In this study, we found that eight of eight thyroid cancer cell lines (including six anaplastic thyroid cell lines) have prominent expression of c-MET protein. Fifty percent of the thyroid cancer cell lines (four of eight) were growth inhibited by two small molecule c-MET inhibitors (tivantinib and crizotinib) associated with apoptosis and G(2)-M cell-cycle arrest. However, crizotinib did not inhibit 50% proliferation of thyroid cancer cells (SW1736 and TL3) at a concentration at which the drug completely inhibited ligand-stimulated c-MET phosphorylation. However, tivantinib was less potent than crizotinib at inhibiting c-MET phosphorylation, but was more potent than crizotinib at decreasing cell growth. Suppressing c-MET protein expression and phosphorylation using siRNA targeting c-MET did not induce cell-cycle arrest and apoptosis. Taken together, tivantinib and crizotinib have off-target(s) activity, contributing to their antitumor activity. In vivo study showed that crizotinib markedly inhibited the growth of thyroid cancer cells (SW1736) in immunodeficient mice. In summary, c-MET inhibitors (tivantinib and crizotinib) suppress the growth of aggressive thyroid cancer cells, and this potential therapeutic benefit results from their non-MET-targeting effects.

Published
2014

10. Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer.

Author

Chan, Daniel, Zheng, Yun, Tyner, Jeffrey W, Chng, Wee Joo, Chien, Wen Wen, Gery, Sigal, Leong, Geraldine, Braunstein, Glenn D, and Koeffler, H Phillip

Subjects
Cell Line, Tumor, Animals, Humans, Mice, Mice, Nude, Thyroid Neoplasms, Sulfonamides, Hydroxamic Acids, Indoles, Blotting, Western, Drug Therapy, Combination, Xenograft Model Antitumor Assays, Cell Cycle, Apoptosis, Cell Proliferation, Acetylation, Drug Synergism, Female, Histone Deacetylase Inhibitors, In Vitro Techniques, Panobinostat, Histone deacetylases, Tyrosine kinase inhibitors, Thyroid cancer, Novel therapeutic approach, Cell Line, Tumor, Nude, Blotting, Western, Drug Therapy, Combination, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

PurposeAdvanced thyroid cancer responds poorly to most therapies. New therapies and combinations are needed. The aim of this study was to examine both in vitro and in vivo activity of two relatively new histone deacetylase inhibitors (HDACIs), belinostat and panobinostat, and a variety of tyrosine kinase inhibitors (TKIs) against a panel of nine human thyroid cancer cell lines.MethodsThe anti-proliferative activity and the effects of HDACIs, TKIs and their combinations on thyroid cancer cells were determined by cytotoxicity assays, microarray and immunoblot analyses. Synergism between HDACIs and TKIs was assessed by the median effects model of Chou-Talalay (Calcusyn(®)).ResultsBelinostat and panobinostat were active against the thyroid cancer cell lines irrespective of their mutational composition, and belinostat was effective in preventing growth of human thyroid cancer xenografts in immunodeficient mice. Further studies showed that both HDACIs induced apoptosis. HDACI also elevated acetylated histone 3, p21(Waf), and PARP, and decreased levels of phosphorylated ERK and AKT (Ser473). RNA assay analysis suggested both HDACIs modulated genes associated with the cell cycle, DNA damage and apoptosis. Most of the TKI (pazopanib, motesanib, sorafenib and dasatinib) were either inactive in vitro or were active only at high doses. However, the novel combinations of either pazopanib or dasatinib TKIs with either belinostat or panobinostat synergistically inhibited cell growth of thyroid cancer cells in vitro.ConclusionsIn summary, these HDACIs either alone or combined with selected TKIs may have a role in treatment of aggressive thyroid cancer.

Published
2013

18. Thyroid Nodules

Author

Braunstein, Glenn D., Sacks, Wendy, Melmed, Shlomo, editor, and Braunstein, Glenn D., editor

Published
2012
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19. Fifteen-Year History of Virilization in a 17th-Century Woman.

Author

BRAUNSTEIN, GLENN D.

Subjects
*OVARIAN tumors, *PORTRAIT painting, *ADENOMA
Abstract

The Spanish artist, Jusepe de Ribera, painted a portrait of a virilized woman in 1631. He provided a brief clinical history on stone tablets, which indicates that the woman most likely harbored a benign, androgen-secreting ovarian tumor for 15 years. [ABSTRACT FROM AUTHOR]

Published
2024

20. Myxedema Coma

Author

Donangelo, Ines, Braunstein, Glenn D., Conn, P. Michael, Series editor, and Loriaux, Lynn, editor

Published
2014
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22. Expanded Parameters in Active Surveillance for Low-risk Papillary Thyroid Carcinoma

Author

Ho, Allen S., primary, Kim, Sungjin, additional, Zalt, Cynthia, additional, Melany, Michelle L., additional, Chen, Irene E., additional, Vasquez, Joan, additional, Mallen-St. Clair, Jon, additional, Chen, Michelle M., additional, Vasquez, Missael, additional, Fan, Xuemo, additional, van Deen, Welmoed K., additional, Haile, Robert W., additional, Daskivich, Timothy J., additional, Zumsteg, Zachary S., additional, Braunstein, Glenn D., additional, and Sacks, Wendy L., additional

Published
2022
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31. Contributors

Author

Achermann, John C., primary, Aiello, Lloyd P., additional, Alexander, Erik K., additional, Allen, Rebecca H., additional, Altshuler, David, additional, Anderson, Mark S., additional, Atkinson, Mark A., additional, Bahn, Rebecca S., additional, Barker, Jennifer M., additional, Basson, Rosemary, additional, Berga, Sarah L., additional, Bhasin, Shalender, additional, Birnbaum, Morris J., additional, Black, Dennis M., additional, Bose, Anirban, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bremner, William J., additional, Brent, Gregory A., additional, Bringhurst, F. Richard, additional, Brownlee, Michael, additional, Bulun, Serdar E., additional, Burant, Charles F., additional, Bushinsky, David A., additional, Cone, Roger D., additional, Cooke, David W., additional, Cooper, Mark E., additional, Cryer, Philip E., additional, Dattani, Mehul T., additional, Davies, Terry F., additional, de Paula, Francisco J.A., additional, Demay, Marie B., additional, DiVall, Sara A., additional, Elmquist, Joel K., additional, Filetti, Sebastiano, additional, Gevers, Evelien F., additional, Ghigo, Ezio, additional, Goldberg, Anne C., additional, Goldberg, Ira J., additional, Gottlieb, Peter A., additional, Grinspoon, Steven K., additional, Grumbach, Melvin M., additional, Hay, Ian D., additional, Hayes, Frances J., additional, Hickey, Martha, additional, Hirschhorn, Joel N., additional, Ho, Ken K.Y., additional, Hughes, Ieuan A., additional, Kaiser, Ursula, additional, Kaunitz, Andrew M., additional, Klein, Samuel, additional, Kleinberg, David, additional, Kronenberg, Henry M., additional, Lamberts, Steven W.J., additional, Lanfranco, Fabio, additional, Larsen, P. Reed, additional, Laurberg, Peter, additional, Lazar, Mitchell A., additional, Loriaux, Lynn, additional, Low, Malcolm J., additional, Majithia, Amit R., additional, Marx, Stephen J., additional, Matsumoto, Alvin M., additional, Melmed, Shlomo, additional, Monk, Rebeca D., additional, Murray, Robert D., additional, Newell-Price, John D.C., additional, Nitsche, Joshua F., additional, Öberg, Kjell, additional, Plutzky, Jorge, additional, Polonsky, Kenneth S., additional, Radovick, Sally, additional, Robinson, Alan G., additional, Romijn, Johannes A., additional, Rosen, Clifford J., additional, Salvatore, Domenico, additional, Schlumberger, Martin-Jean, additional, Semenkovich, Clay F., additional, Sluss, Patrick M., additional, Stewart, Paul M., additional, Strasburger, Christian J., additional, Styne, Dennis M., additional, van den Beld, Annewieke W., additional, Vella, Adrian, additional, Verbalis, Joseph G., additional, Vinik, Aaron I., additional, Weetman, Anthony P., additional, Wells, Samuel A., additional, and Young, William F., additional

Published
2016
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32. Contributors

Author

Aiello, Lloyd Paul, primary, Alatzoglou, Kyriaki S., additional, Alexander, Erik K., additional, Allan, Carolyn A., additional, Allolio, Bruno, additional, Amino, Nobuyuki, additional, Anawalt, Bradley D., additional, Angelos, Peter, additional, Arboleda, Valerie A., additional, Auchus, Richard J., additional, Axelrod, Lloyd, additional, Bahn, Rebecca S., additional, Baker, MD, PhD, FRACP, H.W. Gordon, additional, Barak, Shlomi, additional, Barnes, Randall B., additional, Barthel, Andreas, additional, Bastepe, Murat, additional, Beardsley, Emma K., additional, Beck-Peccoz, Paolo, additional, Bell, Graeme I., additional, Bi, Wenya Linda, additional, Bilezikian, John P., additional, Blum, Manfred, additional, Bonnema, Steen J., additional, Bornstein, Stefan R., additional, Bouillon, Roger, additional, Boulton, Andrew J.M., additional, Braunstein, Glenn D., additional, Bringhurst, F. Richard, additional, Broekmans, Frank J., additional, Bronstein, Marcello D., additional, Brown, Edward M., additional, Brown, Wendy A., additional, Bulun, Serdar E., additional, Burch, Henry B., additional, Burger, Henry G., additional, Burney, Richard O., additional, Burt, Morton G., additional, Cagliero, Enrico, additional, Callender, Glenda G., additional, Avancini Caramori, Maria Luiza, additional, Carey, Robert M., additional, Carling, Tobias, additional, Cavagnini, Francesco, additional, Cavallerano, Jerry D., additional, Challet, Etienne, additional, Chan, Shu Jin, additional, Chang, R. Jeffrey, additional, Chapurlat, Roland D., additional, Chatterjee, V. Krishna, additional, Chiofalo, Francesco, additional, Chiovato, Luca, additional, Cho, Kyung J., additional, Christison-Lagay, Emily, additional, Christophe, Daniel, additional, Chrousos, George P., additional, Cidlowski, John A., additional, Clemmons, David R., additional, Considine, Robert V., additional, Conti, Marco, additional, Copinschi, Georges, additional, Copps, Kyle D., additional, Cowley, Michael A., additional, Cuttler, Leona, additional, Dattani, Mehul T., additional, Davis, Stephen N., additional, De Felice, Mario, additional, De Groot, Leslie J., additional, de Kretser, David M., additional, DeFronzo, Ralph A., additional, Delli, Ahmed J., additional, Demay, Marie B., additional, Dennedy, Michael C., additional, Di Lauro, Roberto, additional, Dineen, Rosemary, additional, Ding, Su Ann, additional, Dinneen, Sean F., additional, Drucker, Daniel J., additional, Dumont, Jacques E., additional, Dungan, Kathleen M., additional, Dunn, Ian F., additional, Econs, Michael J., additional, Ehrmann, David A., additional, Eisenhofer, Graeme, additional, Ergun-Longmire, Berrin, additional, Eugster, Erica A., additional, Farooqi, Sadaf I., additional, Fassnacht, Martin, additional, Fauser, Bart C.J.M., additional, Fenzi, Gianfranco, additional, Ferrannini, Ele, additional, Findlay, David M., additional, Finlayson, Courtney Anne, additional, Fisher, Delbert A., additional, Francis, Isaac R., additional, Freeman, Mason W., additional, Frohman, Lawrence A., additional, Frydenberg, Mark, additional, Fuller, Peter J., additional, Gaglia, Jason L., additional, Galizia, Gianluigi, additional, Gardella, Thomas J., additional, Garvey, Katharine C., additional, Genant, Harry K., additional, German, Michael S., additional, Gevers, Evelien F., additional, Giraldi, Francesca Pecori, additional, Giudice, Linda C., additional, Giustina, Andrea, additional, Glasier, Anna, additional, Glorieux, Francis H., additional, Goldfine, Allison B., additional, Gooren, Louis J., additional, Gordon, David F., additional, Gregerson, Karen A., additional, Grogan, Raymon H., additional, Gross, Milton D., additional, Grossman, Ashley B., additional, Gruber, Matthias, additional, Guimarães, Valeria C., additional, Gurnell, Mark, additional, Haddad, Nadine G., additional, Haisenleder, Daniel J., additional, Handelsman, David J., additional, Hanks, John B., additional, Hannon, Mark J., additional, Harno, Erika, additional, Hebrok, Matthias, additional, Hedger, Mark P., additional, Hegedüs, Laszlo, additional, Heindel, Jerrold J., additional, Hernandez, Arturo, additional, Herndon, Maria K., additional, Ho, Ken K.Y., additional, Horseman, Nelson D., additional, Hughes, Ieuan A., additional, Hupfeld, Christopher J., additional, Hussain, Hero K., additional, Iodice, Valeria, additional, James, Benjamin C., additional, Jameson, J. Larry, additional, Jones, Glenville, additional, Josso, Nathalie, additional, Jüppner, Harald, additional, Juszczak, Agata, additional, Kalish, Jeffrey, additional, Kaplan, Edwin L., additional, Karavitaki, Niki, additional, Karczewska-Kupczewska, Monika, additional, Khattab, Ahmed, additional, Klein, David C., additional, Klein, Ronald, additional, Kleinau, Gunnar, additional, Koontz, Michaela, additional, Kopchick, John J., additional, Kopp, Peter, additional, Kowalska, Irina, additional, Krane, Stephen M., additional, Krohn, Knut, additional, Kronenberg, Henry M., additional, Lamos, Elizabeth M., additional, Lania, Andrea, additional, Lau, Sue Lynn, additional, Laws, Edward R., additional, Lazarus, John H., additional, Learoyd, Diana L., additional, Lebovitz, Harold E., additional, Lenmark, Åke, additional, List, Edward O., additional, Loveland, Kate, additional, Low, David A., additional, Macchia, Paolo E., additional, Maclaren, Noel K., additional, Madeiros-Neto, Geraldo, additional, Maenhaut, Carine, additional, Maes, Christa, additional, Main, Katharina M., additional, Malchoff, Carl D., additional, Malchoff, Diana M., additional, Malik, Rayaz A., additional, Mandel, Susan J., additional, Mantzoros, Christos S., additional, Maratos-Flier, Eleftheria, additional, Marino, Michele, additional, Marshall, John C., additional, Martin, T. John, additional, Martin, Thomas F.J., additional, Mathias, Christopher J., additional, McGee, Elizabeth A., additional, McKenzie, Travis, additional, McLachlan, Robert I., additional, Meier, Juris J., additional, Melmed, Shlomo, additional, Metzger, Boyd E., additional, Meyer-Bahlburg, Heino F.L., additional, Millar, Robert P., additional, Miller, Walter L., additional, Misra, Madhusmita, additional, Molitch, Mark E., additional, Moravek, Molly B., additional, Morris, Damian G., additional, Nagar, Sapna, additional, Nakamoto, Jon, additional, New, Maria I., additional, Nieman, Lynnette K., additional, Nilson, John H., additional, Ntali, Georgia, additional, O’Bryan, Moira, additional, O’Rahilly, Stephen, additional, Öberg, Kjell, additional, Olefsky, Jerrold M., additional, Olson, Matthew T., additional, Pacak, Karel, additional, Pacini, Furio, additional, Padia, Shetal H., additional, Paschke, Ralf, additional, Pasquel, Francisco J., additional, Perry, Katherine Wesseling, additional, Persani, Luca, additional, Philipson, Louis H., additional, Pina, Christian, additional, Pomposelli, Frank B., additional, Potts, John T., additional, Quigley, Charmian A., additional, Quinkler, Marcus O., additional, Quirk, Christine Campion, additional, Rajpert-De Meyts, Ewa, additional, Ravussin, Eric, additional, Ray, David W., additional, Refetoff, Samuel, additional, Retnakaran, Ravi, additional, Rey, Rodolfo A., additional, Rhodes, Christopher J., additional, Ridgway, E. Chester, additional, Risbridger, Gail P., additional, Rizza, Robert A., additional, Robinson, Bruce G., additional, Roger, Pierre P., additional, Rosenfeld, Michael G., additional, Rosenfield, Robert L., additional, Rossing, Peter, additional, Rubin, Robert T., additional, Rubio, Ileana G.S., additional, Ruderman, Neil B., additional, Russo, Jose, additional, Russo, Irma H., additional, Salusky, Isidro B., additional, Santoro, Nanette, additional, Scully, Kathleen M., additional, Sexton, Patrick M., additional, Shulman, Gerald I., additional, Silva, Paolo S., additional, Silverberg, Shonni J., additional, Singer, Frederick R., additional, Skakkebaek, Niels E., additional, Skaznik-Wikiel, Malgorzata E., additional, Skowronska-Krawczyk, Dorota, additional, Smith, Carolyn L., additional, Smith, Philip W., additional, Smith, Roger, additional, Smith, Steven R., additional, Snyder, Peter J., additional, St. Germain, Donald L., additional, St-Arnaud, René, additional, Steiner, Donald F., additional, Stewart, Paul M., additional, Strączkowski, Marek, additional, Strauss, Jerome F., additional, Styne, Dennis M., additional, Swan, Karena L., additional, Swerdloff, Ronald S., additional, Tacon, Lyndal J., additional, Tello, Javier A., additional, Thakker, Rajesh V., additional, Thompson, Christopher J., additional, Timmers, Henri J.L.M., additional, Toppari, Jorma, additional, Traub, Michael L., additional, Tsoukas, Michael A., additional, Udelsman, Robert, additional, Umpierrez, Guillermo E., additional, Van den Berghe, Greet, additional, Vassart, Gilbert, additional, Vernon, Ashley H., additional, Vilain, Eric, additional, Visser, Theo J., additional, Vitti, Paolo, additional, Walford, Geoffrey A., additional, Wang, Christina, additional, Weetman, Anthony P., additional, Weigel, Nancy L., additional, Weir, Gordon C., additional, Weiss, Roy E., additional, White, Anne, additional, White, Kenneth E., additional, White, Morris F., additional, Whyte, Michael P., additional, Wiersinga, Wilmar M., additional, Willenberg, Holger S., additional, Wolfsdorf, Joseph I., additional, Wondisford, Fredric E., additional, Wong, Ka Kit, additional, Wysolmerski, John J., additional, Yau, Mabel, additional, Young, Morag J., additional, Younk, Lisa M., additional, Yu, Run, additional, Yuen, Tony, additional, Zeiger, Martha A., additional, Zinman, Bernard, additional, and Zoeller, R. Thomas, additional

Published
2016
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49. Testosterone for low libido in postmenopausal women not taking estrogen

Author

Davis, Susan R., Moreau, Michele, Kroll, Robin, Bouchard, Celine, Panay, Nick, Gass, Margery, Braunstein, Glenn D., Hirschberg, Angelica Linden, Rodenberg, Cynthia, Pack, Simon, Moufarege, Alain, and Studd, John

Subjects
Testosterone -- Usage, Testosterone -- Health aspects, Blood diseases -- Care and treatment, Hormone therapy -- Usage, Hormone therapy -- Health aspects
Abstract

A study was conducted to determine the efficacy and safety of testosterone as a form of treatment for low libido in postmenopausal women not taking estrogen. Results indicated that testosterone treatment was effective in a modest and meaningful improvement in sexual function among postmenopausal women not taking estrogen.

Published
2008

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