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5. Plasmapherese und Immunadsorption

Author

Braun, Norbert, Risler, Teut, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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6. Storytelling & Conversation to Improve the Fun Factor in Software Applications

Author

Braun, Norbert, Karat, John, editor, Vanderdonckt, Jean, editor, Abowd, Gregory, editor, Calvary, Gaälle, editor, Carroll, John, editor, Cockton, Gilbert, editor, Czerwinski, Mary, editor, Feiner, Steve, editor, Furtado, Elizabeth, editor, Höök, Kristiana, editor, Jacob, Robert, editor, Jeffries, Robin, editor, Johnson, Peter, editor, Nakakoji, Kumiyo, editor, Palanque, Philippe, editor, Pastor, Oscar, editor, Paternò, Fabio, editor, Pribeanu, Costin, editor, Salzman, Marilyn, editor, Schmandt, Chris, editor, Stolze, Markus, editor, Szwillus, Gerd, editor, Tscheligi, Manfred, editor, van der Veer, Gerrit, editor, Zhai, Shumin, editor, Blythe, Mark A., editor, Overbeeke, Kees, editor, Monk, Andrew F., editor, and Wright, Peter C., editor

Published
2004
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7. A Graphical System for Interactive Rendering of Objects in an Augmented Reality Scenery

Author

Berner, Uwe, Braun, Norbert, Kolebinova, Sofia, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, and Rauterberg, Matthias, editor

Published
2004
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8. Evaluation of a Virtual Narrator’s Expressiveness in Terms of Suspense Signaling

Author

Braun, Norbert, Rieger, Thomas, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Göbel, Stefan, editor, Spierling, Ulrike, editor, Hoffmann, Anja, editor, Iurgel, Ido, editor, Schneider, Oliver, editor, Dechau, Johanna, editor, and Feix, Axel, editor

Published
2004
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9. Immunologisch bedingte Krankheiten

Author

Schröder, Johann O., Grimbacher, Bodo, Sticherling, Michael, Lorenz, Hanns-Martin, Moosig, Frank, Volc-Platzer, Beatrix, Hunzelmann, N., Gause, Angela, Ehlert, Andreas, Müller-Ladner, Ulf, Braun, Norbert, Risler, Teut, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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19. Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling

Author

Kishore, Bellamkonda K., Isaac, Jorge, Fausther, Michel, Tripp, Sheryl R., Shi, Huihui, Gill, Pritmohinder S., Braun, Norbert, Zimmermann, Herbert, Sevigny, Jean, and Robson, Simon C.

Subjects
Adenosine triphosphate -- Research, Hemodynamics -- Research, Nucleotides -- Research, Kidneys -- Research, Biological sciences
Abstract

The regulation of renal function by extracellular nucleotides encompasses alterations in glomerular hemodynamics, microvascular function, tubuloglomerular feedback, tubular transport, cell growth or apoptosis, and transport of water and solutes in the medullary collecting duct. Nearly all cells can release ATP or other nucleotides that are then rapidly hydrolyzed in the extracellular milieu. However, little information is available on the cellular expression of ectoenzymes that hydrolyze extracellular nucleotides within the kidney. Nucleoside triphosphate diphosphohydrolases (NTPDases) are plasma membrane-bound ectonucleotidases. NTPDase1 has identity with CD39, a B lymphocyte activation marker, and hydrolyzes extracellular ATP and ADP to AMP within the vasculature, whereas NTPDase2/CD39L(ike)1 preferentially converts ATP to ADP outside of blood vessels. Using immunohistochemical and in situ hybridization approaches, we localized the protein and mRNA of NTPDase1 and 2 in murine renal tissues. In the renal cortex, NTPDase1 is expressed by vascular smooth muscle cells and endothelium in interlobular arteries, afferent glomerular arterioles, and peritubular capillaries. In the inner medulla, NTPDase1 is expressed in ascending thin limbs of Henle's loop, ducts of Bellini, and in the pelvic wall. In contrast, NTPDase2 is expressed in Bowman's capsule, glomerular arterioles, adventitia of blood vessels, and pelvic wall. Thus the distribution patterns of NTPDases have parallels to the known distribution of P2 receptors within the kidney. NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney. ectonucleotidases; CD39; ATP; immunohistochemistry; in situ hybridization

Published
2005

24. New oxidative transformations of phenolic and indolic oxazolines: an avenue to useful azaspirocyclic building blocks

Author

Braun, Norbert A., Ousmer, Malika, Bray, Jonathan D., Bouchu, Denis, Peters, Karl, Peters, Eva-maria, and Ciufolini, Marco A.

Subjects
Natural products -- Research, Organic compounds -- Synthesis, Ring formation (Chemistry) -- Methods, Phenols -- Research, Biological sciences, Chemistry
Abstract

Research points out that the oxidative cyclization of phenolic omega-arylalkanoic carboxamides to spirolactams can be accomplished using iodobenzene diacetate via oxazoline intermediates. Results suggest that these transformations of the organic hypervalent iodine chemistry are useful in the syntheses of azaspirocyclic products.

Published
2000

40. Survival and functionality of xeno‐free human embryonic stem cell–derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits

Author

Ilmarinen, Tanja, primary, Thieltges, Fabian, additional, Hongisto, Heidi, additional, Juuti‐Uusitalo, Kati, additional, Koistinen, Arto, additional, Kaarniranta, Kai, additional, Brinken, Ralf, additional, Braun, Norbert, additional, Holz, Frank G., additional, Skottman, Heli, additional, and Stanzel, Boris V., additional

Published
2018
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45. UCP-3 Uncoupling Protein Confers Hypoxia Resistance to Renal Epithelial Cells and is Upregulated in Renal Cell Carcinoma

Author

Braun, Norbert and Huber, Stephan (Prof. Dr. rer. nat)

Subjects
UCP3, Uncoupling, Hypoxie , Nierentumor , Bestrahlung , Resistenz , Membranpotenzial
Abstract

Tumor cells can adapt to a hostile environment with reduced oxygen supply. The present study aimed to identify mechanisms that confer hypoxia resistance. Partially hypoxia/reoxygenation (H/R)-resistant proximal tubular (PT) cells were selected by exposing PT cultures to repetitive cycles of H/R. Thereafter, H/R-induced changes in mRNA and protein expression, inner mitochondrial membrane potential (Delta Psi m), formation of superoxide, and cell death were compared between H/R-adapted and control PT cultures. As a result, H/R-adapted PT cells exhibited lower H/R-induced hyperpolarization of Delta Psi m and produced less superoxide than the control cultures. As a consequence, H/R triggered Delta Psi m break-down and DNA degradation in a lower percentage of H/R-adapted than control PT cells. Moreover, H/R induced upregulation of mitochondrial uncoupling protein 3 (UCP-3) in H/R-adapted PT but not in control cultures. In addition, ionizing radiation killed a lower percentage of H/R-adapted compared to control cells suggestive of an H/R-radiation cross-resistance developed by the selection procedure. Knockdown of UCP-3 decreased H/R- and radioresistance of the H/R-adapted cells. Finally, UCP-3 protein abundance of PT-derived clear cell renal cell carcinoma and normal renal tissue was compared in human specimens indicating upregulation of UCP-3 during tumor development. Combined, our data suggest functional significance of UCP-3 for H/R resistance., Tumorzellen können sich an ein hypoxisches Milieu anpassen. Die vorliegende Studie untersucht Mechanismen, die zu einer Resistenz gegenüber Hypoxie beitragen können. Partiell gegenüber Hypoxie/Reoxigenierung (H/R) unempfindliche proximale Tubuluszellen (PT) wurden durch repetitive Zyklen von Hypoxie und Reoxigenierung aus ursprünglichen PT-Kulturen herausselektioniert. Im Anschluss erfolgte eine Untersuchung der H/R induzierten Veränderungen hinsichtlich der mRNA- und Proteinexpression, des mitochondrialen Membranpotentials, der Bildung freier O2-Radikale und des induzierten Zelltodes verglichen mit den unselektionierten Kontrollkulturen. H/R-angepasste Zellen zeigten eine geringere H/R bedingte Hyperpolarisierung des mitochondrialen Membranpotentials und eine geringere Bildung freier O2-Radikale. In der Folge verursachte H/R bei den angepassten Zellen in einem geringeren Prozentsatz einen Zusammenbruch des Membranpotentials und der DNA-Degradierung. Zudem wurde durch H/R in den selektionierten Zellen das Uncoupling Protein 3 (UCP-3) im Vergleich zu den Kontrollzellen stärker exprimiert. Des Weiteren hatte Bestrahlung in den selektionierten Zellen eine geringere Wirkung als in den Kontrollzellen, was auf eine Kreuzresistenz durch den Selektionierungsprozess hindeutet. Eine Herunterregulation der UCP-3 Expression führte zu einer Verringerung der Resistenz gegenüber H/R und Bestrahlung. Zuletzt erfolgte ein Vergleich der UCP-3 Expression in aus Tubuluszellen enstehenden klarzelligen Nierenzellkarzinomen und normalem Nierengewebe menschlichen Ursprungs. Zusammenfassend weisen die vorliegenden Daten auf die Bedeutung von UCP-3 für die H/R Resistenz hin.

Published
2017
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47. Verbesserung der Lebensdauer von medizinischen Modellen durch niederschwellig produzierte Instruktionsvideos

Author

Michel, Adrian, Woermann, Ulrich, Schnabel, Kai, Braun, Norbert, and Ferrieri, Giovanni

Subjects
ddc: 610, 610 Medicine & health, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Medizinische Simulatoren sind aus der ärztlichen Ausbildung nicht mehr wegzudenken und notwendiger Bestandteil zum Erwerb praktischer Fertigkeiten und konventionellem Unterricht in vielen Bereichen überlegen [ref:1]. Falsche praktische Handhabung der Simulatoren verringert[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA)

Published
2016

48. Let's go to Hollywood - Lehre zwischen Wissensvermittlung und Unterhaltung

Author

Braun, Norbert, Woermann, Ulrich, Michel, Adrian, Schnabel, Kai, Ferrieri, Giovanni, and Brem, Beate

Subjects
ddc: 610, 610 Medicine & health, 610 Medical sciences, Medicine
Abstract

Hintergrund: Aufmerksamkeit und Motivation sind wichtige Elemente des Lernens [ref:1]. Wie aber wird diese erreicht? Heranwachsende Studentengenerationen sind immer mehr durch die Präsenz neuer Medien geprägt. Ihre Aufmerksamkeit zu erlangen wird dadurch nicht leichter. Neue[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA)

Published
2016

49. UCP-3 uncoupling protein confers hypoxia resistance to renal epithelial cells and is upregulated in renal cell carcinoma

Author

Braun, Norbert, Klumpp, Dominik, Hennenlotter, Jörg, Bedke, Jens, Duranton, Christophe, Bleif, Martin, and Huber, Stephan M.

Subjects
Male, Epithelial Cells, Article, Cell Hypoxia, Ion Channels, Kidney Neoplasms, Up-Regulation, Mitochondrial Proteins, Oxygen, Oxidative Stress, Tumor Cells, Cultured, Humans, Uncoupling Protein 3, Female, Carcinoma, Renal Cell, Aged
Abstract

Tumor cells can adapt to a hostile environment with reduced oxygen supply. The present study aimed to identify mechanisms that confer hypoxia resistance. Partially hypoxia/reoxygenation (H/R)-resistant proximal tubular (PT) cells were selected by exposing PT cultures to repetitive cycles of H/R. Thereafter, H/R-induced changes in mRNA and protein expression, inner mitochondrial membrane potential (ΔΨ(m)), formation of superoxide, and cell death were compared between H/R-adapted and control PT cultures. As a result, H/R-adapted PT cells exhibited lower H/R-induced hyperpolarization of ΔΨ(m) and produced less superoxide than the control cultures. Consequently, H/R triggered ΔΨ(m) break-down and DNA degradation in a lower percentage of H/R-adapted than control PT cells. Moreover, H/R induced upregulation of mitochondrial uncoupling protein-3 (UCP-3) in H/R-adapted PT but not in control cultures. In addition, ionizing radiation killed a lower percentage of H/R-adapted as compared to control cells suggestive of an H/R-radiation cross-resistance developed by the selection procedure. Knockdown of UCP-3 decreased H/R- and radioresitance of the H/R-adapted cells. Finally, UCP-3 protein abundance of PT-derived clear cell renal cell carcinoma and normal renal tissue was compared in human specimens indicating upregulation of UCP-3 during tumor development. Combined, our data suggest functional significance of UCP-3 for H/R resistance.

Published
2015
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50. Survival and functionality of xeno‐free human embryonic stem cell–derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.

Author

Ilmarinen, Tanja, Thieltges, Fabian, Hongisto, Heidi, Juuti‐Uusitalo, Kati, Koistinen, Arto, Kaarniranta, Kai, Brinken, Ralf, Braun, Norbert, Holz, Frank G., Skottman, Heli, and Stanzel, Boris V.

Subjects
RHODOPSIN, EPITHELIAL cells, BIOLOGICAL pigments, RABBITS, MAJOR histocompatibility complex
Abstract

Purpose: To study immunogenic properties of human embryonic stem cell–derived retinal pigment epithelium (hESC‐RPE) and to evaluate subretinal xenotransplantation of hESC‐RPE on porous polyethylene terephthalate (PET) in rabbits. Methods: Human ESC‐RPE cells were characterized by morphology, transepithelial electrical resistance (TER), protein expression and photoreceptor outer segment phagocytosis in vitro. Expression of major histocompatibility complex (MHC) proteins was assessed in conventionally or xeno‐free produced hESC‐RPE ± interferon‐gamma (IFN‐γ) stimulation (n = 1). Xeno‐free hESC‐RPE on PET with TER < 200 Ω·cm2 > or PET alone were transplanted into 18 rabbits with short‐term triamcinolone ± extended tacrolimus immunosuppression. Rabbits were monitored by spectral domain optical coherence tomography. After 4 weeks, the eyes were processed for histology and transmission electron microscopy. Results: Upon in vitro IFN‐γ stimulation, xeno‐free hESC‐RPE expressed lower level of MHC‐II proteins compared to the conventional cells. Outer nuclear layer (ONL) atrophy was observed over the graft in most cases 4 weeks post‐transplantation. In 3/4 animals with high TER hESC‐RPE, but only in 1/3 animals with low TER hESC‐RPE, ONL atrophy was observed already within 1 week. Retinal cell infiltrations were more frequent in animals with high TER hESC‐RPE. However, the difference was not statistically significant. In three animals, preservation of ONL was observed. Weekly intravitreal tacrolimus did not affect ONL preservation. In all animals, hESC‐RPE cells survived for 4 weeks, but without tacrolimus, enlarged vacuoles accumulated in hESC‐RPE (n = 1). Conclusions: Xenografted xeno‐free hESC‐RPE monolayers can survive and retain some functionality for 4 weeks following short‐term immunosuppression. The preliminary findings of this study suggest that further investigations to improve transplantation success of hESC‐RPE xenografts in rabbits should be addressed especially toward the roles of hESC‐RPE maturation stage and extended intravitreal immunosuppression. [ABSTRACT FROM AUTHOR]

Published
2019
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