Search

Your search keyword '"Brasil, Patrícia"' showing total 557 results
Start Over Author "Brasil, Patrícia"
557 results on '"Brasil, Patrícia"'

1. The Role of Children in Household Transmission of SARS-CoV-2 Across Four Waves of the Pandemic.

Author

Fuller, Trevon, Bastos, Leonardo, Carvalho, Marilia, Resende, Paola, Damasceno, Luana, Cruz, Oswaldo, Medeiros, Fernando, Calvet, Guilherme, Guaraldo, Lusiele, Nielsen-Saines, Karin, Whitworth, James, Smith, Christopher, Siqueira, Marilda, and Brasil, Patrícia

Subjects
COVID-19 vaccines, SARS-CoV-2 variants, extended family, inactivated vaccines, transmission, Adult, Female, Adolescent, Child, Humans, SARS-CoV-2, COVID-19, Prospective Studies, Pandemics, Family Characteristics
Abstract

BACKGROUND: It is important to understand the dynamics of SARS-CoV-2 transmission in close-contact settings such as households. We hypothesized that children would most often acquire SARS-CoV-2 from a symptomatic adult caregiver. METHODS: This prospective cohort study was conducted from April 2020 to July 2022 in a low-resource, urban settlement in Brazil. We recruited families who brought their children to a public clinic. We collected nasopharyngeal and oral swabs from household members and tracked symptoms and vaccination. RESULTS: In total, 1256 participants in 298 households were tested for SARS-CoV-2. A total of 4073 RT-PCR tests were run with 893 SARS-CoV-2 positive results (21.9%). SARS-CoV-2 cases were defined as isolated cases (N = 158) or well-defined transmission events (N = 175). The risk of household transmission was lower if the index case was a child (OR: 0.3 [95% CI: 0.16-0.55], P < .001) or was vaccinated (OR: 0.29 [95% CI: 0.1-0.85], P = .024), and higher if the index was symptomatic (OR: 2.53 [95% CI: 1.51-4.26], P < .001). The secondary attack rate for child index cases to child contacts was 0.29, whereas the secondary attack rate for adult index cases to child contacts was 0.47 (P = .08). CONCLUSIONS: In this community, children were significantly less infectious to their household contacts than adolescents or adults. Most children were infected by a symptomatic adult, usually their mother. There was a double benefit of vaccination as it protected the vaccine from severe illness and prevented onward transmission to household contacts. Our findings may also be valid for similar populations throughout Latin America.

Published
2023

2. Accuracy of saliva for SARS-CoV-2 detection in outpatients and their household contacts during the circulation of the Omicron variant of concern.

Author

Calvet, Guilherme, Ogrzewalska, Maria, Tassinari, Wagner, Guaraldo, Lusiele, Resende, Paola, Fuller, Trevon, Penetra, Stephanie, Borges, Michele, Pina-Costa, Anielle, Martins, Ezequias, Moraes, Isabella, Santos, Heloisa, Damasceno, Luana, Medeiros-Filho, Fernando, Espindola, Otavio, Mota, Fernando, Nacife, Valéria, Pauvolid-Corrêa, Alex, Whitworth, Jimmy, Smith, Chris, Siqueira, Marilda, and Brasil, Patrícia

Subjects
Nasopharynx, Saliva, Humans, Specimen Handling, Adolescent, Adult, Child, Outpatients, COVID-19, SARS-CoV-2, COVID-19 Testing, Accuracy, Omicron, Clinical Research, Lung, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Microbiology, Clinical Sciences, Medical Microbiology
Abstract

BackgroundWhile nasopharyngeal (NP) swabs are considered the gold standard for severe acute respiratory coronavirus 2 (SARS-CoV-2) real-time reverse transcriptase-polymerase chain reaction (RT-PCR) detection, several studies have shown that saliva is an alternative specimen for COVID-19 diagnosis and screening.MethodsTo analyze the utility of saliva for the diagnosis of COVID-19 during the circulation of the Omicron variant, participants were enrolled in an ongoing cohort designed to assess the natural history of SARS-CoV-2 infection in adults and children. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Cohen's kappa coefficient were calculated to assess diagnostic performance.ResultsOverall, 818 samples were collected from 365 outpatients from January 3 to February 2, 2022. The median age was 32.8 years (range: 3-94 years). RT-PCR for SARS-CoV-2 was confirmed in 97/121 symptomatic patients (80.2%) and 62/244 (25.4%) asymptomatic patients. Substantial agreement between saliva and combined nasopharyngeal/oropharyngeal samples was observed with a Cohen's kappa value of 0.74 [95% confidence interval (CI): 0.67-0.81]. Sensitivity was 77% (95% CI: 70.9-82.2), specificity 95% (95% CI: 91.9-97), PPV 89.8% (95% CI: 83.1-94.4), NPV 87.9% (95% CI: 83.6-91.5), and accuracy 88.5% (95% CI: 85.0-91.4). Sensitivity was higher among samples collected from symptomatic children aged three years and older and adolescents [84% (95% CI: 70.5-92)] with a Cohen's kappa value of 0.63 (95% CI: 0.35-0.91).ConclusionsSaliva is a reliable fluid for detecting SARS-CoV-2, especially in symptomatic children and adolescents during the circulation of the Omicron variant.

Published
2023

3. Severe maternal morbidity and mortality during the COVID-19 pandemic: a cohort study in Rio de Janeiro.

Author

Brendolin, Michelle, Fuller, Trevon, Wakimoto, Mayumi, Rangel, Larissa, Rodrigues, Gustavo Mourão, Rohloff, Roger D, Guaraldo, Lusiele, Nielsen-Saines, Karin, and Brasil, Patrícia

Subjects
Adverse outcomes, COVID-19, Immunization, Maternal mortality, Pregnant women, SARS-CoV-2, Infectious Diseases, Emerging Infectious Diseases, Vaccine Related, Lung, Prevention, Aetiology, 2.4 Surveillance and distribution, Reproductive health and childbirth, Infection, Good Health and Well Being
Abstract

ObjectivesTo identify factors associated with adverse maternal outcomes during the coronavirus disease 2019 (COVID-19) pandemic.MethodsThis was a single-centre prospective cohort study at a maternity department in a public general hospital in Rio de Janeiro. All pregnant women evaluated for emergency care, labour and delivery, respiratory symptoms, obstetric reasons or medical reasons between May 2020 and March 2022 at the study institution were invited to enrol in this study. The endpoint was maternal mortality or intensive care unit (ICU) admission.ResultsIn total, 1609 pregnant women were enrolled in this study. Of these, 25.5% (n=410) were infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) based on reverse transcription polymerase chain reaction or an antigen test. There were 21 deaths and 67 ICU admissions in 4% of the cohort. The incidence of severe maternal morbidity and mortality was higher during the Gamma wave than during the Delta wave (P=0.003). Vaccination conferred protection against the endpoint [relative risk (RR) 0.4, 95% confidence interval (CI) 0.1-0.9; P=0.0169]. Factors associated with severe morbidity and mortality included caesarean section (RR 3.7, 95% CI 1.7-7.9; P=0.0008), SARS-CoV-2 infection in the third trimester (RR 2.4, 95% CI 1.1-5.6; P=0.0006) and comorbidities (RR 3, 95% CI 1.8-5.2; P

Published
2023

4. Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.

Author

Espíndola, Otávio, Resende, Paola, Guaraldo, Lusiele, Calvet, Guilherme, Fuller, Trevon, Penetra, Stephanie, Santos, Heloisa, Pina-Costa, Anielle, da Silva, Michele, Moraes, Isabella, Medeiros, Fernando, Whitworth, Jimmy, Smith, Christopher, Nielsen-Saines, Karin, Siqueira, Marilda, and Brasil, Patrícia

Subjects
Female, Humans, Aged, COVID-19, SARS-CoV-2, Post-Acute COVID-19 Syndrome, Brazil, Chromosome Mapping
Abstract

BACKGROUND: There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023. OBJECTIVES: The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19. METHODS: We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing. FINDINGS: The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue. MAIN CONCLUSIONS: This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants.

Published
2023

5. Reduced ability to neutralize the Omicron variant among adults after infection and complete vaccination with BNT162b2, ChAdOx1, or CoronaVac and heterologous boosting

Author

Espíndola, Otávio Melo, Fuller, Trevon L, de Araújo, Mia Ferreira, Tort, Luis Fernando Lopez, Guaraldo, Lusiele, Calvet, Guilherme, Resende, Paola, Bonaldo, Myrna, Whitworth, Jimmy, Smith, Chris, Siqueira, Marilda, and Brasil, Patrícia

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Pneumonia, Biotechnology, Prevention, Emerging Infectious Diseases, Lung, Immunization, Infectious Diseases, Pneumonia & Influenza, Biodefense, Vaccine Related, 3.4 Vaccines, Prevention of disease and conditions, and promotion of well-being, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, Humans, COVID-19 Vaccines, BNT162 Vaccine, COVID-19, SARS-CoV-2, Vaccination, Antibodies, Neutralizing, Antibodies, Viral
Abstract

COVID-19 vaccines have dramatically reduced rates of severe infection requiring hospitalization. However, SARS-CoV-2 variants have reduced vaccine effectiveness at preventing any symptomatic infection. This real-world study analyzed binding and neutralizing antibodies generated after complete vaccination and boosting across three vaccine platforms. Binding antibodies decayed most slowly in people under 60 with hybrid immunity. Neutralizing antibodies against Omicron BA.1 were reduced compared to other variants. The anamnestic anti-spike IgG response to the first boost was more pronounced than after the second boost. Monitoring of the effects of SARS-CoV-2 mutations on disease severity and the effectiveness of therapeutics is warranted.

Published
2023

6. Cohort-profile: Household transmission of SARS-CoV-2 in a low-resource community in Rio de Janeiro, Brazil

Author

Brasil, Patrícia, Damasceno, Luana, Fuller, Trevon, Bastos, Leonardo S, Cruz, Oswaldo G, Medeiros, Fernando, Calvet, Guilherme Amaral, Resende, Paola, Whitworth, Jimmy, Smith, Chris, Siqueira, Marilda M, and Carvalho, Marilia

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Prevention, Clinical Research, Infectious Diseases, Emerging Infectious Diseases, Biodefense, Immunization, Vaccine Related, Biotechnology, Lung, Infection, Good Health and Well Being, Adult, Child, Humans, Female, Male, SARS-CoV-2, COVID-19, Prospective Studies, Pandemics, Brazil, Antibodies, Community child health, Epidemiology, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

PurposeTo better understand the household transmission of SARS-COV-2 in a low-resource community in Rio de Janeiro during the COVID-19 pandemic (2020-2022).ParticipantsThis is an open prospective cohort study of children ≤12 years old and their household contacts. During home visits over 24 months, we collected data on sociodemographic characteristics, behavioural data, clinical manifestations of SARS-CoV-2, vaccination status, SARS-CoV-2 (reverse transcription-polymerase chain reaction) RT-PCR and anti-S antibody tests. Among adults, the majority of participants were women (62%).Findings to dateWe enrolled 845 families from May 2020 to May 2022. The median number of residents per household was four. The median household density, defined as the number of persons per room, was 0.95. The risk of SARS-CoV-2 occurrence was higher in households with a high number of persons per room. Children were not the principal source of SARS-CoV-2 infections in their households during the first wave of the pandemic.Future plansFuture studies will investigate cellular and humoral immune responses to locally circulating SARS-CoV-2 variants, which is relevant for the design of vaccines, antivirals and monoclonal antibodies. We will also engage in outreach to encourage vaccination as a means of limiting the transmission of novel SARS-CoV-2 variants and other emerging pathogens.

Published
2022

8. Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study

Author

Calvet, Guilherme Amaral, Kara, Edna Oliveira, Bôtto-Menezes, Camila Helena Aguiar, da Costa Castilho, Marcia, de Oliveira Franca, Rafael Freitas, Habib, Ndema, Neto, Armando Menezes, Pereira, Gerson Fernando Mendes, Giozza, Silvana Pereira, Bermúdez, Ximena Pamela Díaz, Fernandes, Tatiana Jorge, Modjarrad, Kayvon, Brasil, Patrícia, Broutet, Nathalie Jeanne Nicole, and de Filippis, Ana Maria Bispo

Published
2023
Full Text
View/download PDF

9. A fatal respiratory complication of malaria caused by Plasmodium vivax

Author

López, Angie R., Martins, Ezequias B., de Pina-Costa, Anielle, Pacheco-Silva, Ana Beatriz, Ferreira, Marcel T., Mamani, Roxana F., Detepo, Paula J. T., Lupi, Otilia, Bressan, Clarisse S., Calvet, Guilherme A., Silva, Michele F. B., de Fátima Ferreira-da-Cruz, Maria, de Bruycker-Nogueira, Fernanda, Filippis, Ana Maria B., Daniel-Ribeiro, Cláudio Tadeu, Siqueira, André, and Brasil, Patrícia

Published
2023
Full Text
View/download PDF

11. SARS-CoV-2 intra-host diversity, antibody response, and disease severity after reinfection by the variant of concern Gamma in Brazil

Author

Naveca, Felipe Gomes, Nascimento, Valdinete Alves, Nascimento, Fernanda, Ogrzewalska, Maria, Pauvolid-Corrêa, Alex, Araújo, Mia Ferreira, Arantes, Ighor, Batista, Érika Rocha, Magalhães, Alessandro Álvares, Vinhal, Fernando, Mattos, Tirza Peixoto, Riediger, Irina, Debur, Maria do Carmo, Grinsztejn, Beatriz, Veloso, Valdiléa G., Brasil, Patrícia, Rodrigues, Rodrigo Ribeiro, Rovaris, Darcita Buerger, Fernandes, Sandra Bianchini, Fernandes, Cristiano, Santos, João Hugo Abdalla, Abdalla, Lígia Fernandes, Costa-Filho, Rubens, Silva, Marineide, Souza, Victor, Costa, Ágatha Araújo, Mejía, Matilde, Brandão, Maria Júlia, Gonçalves, Luciana Fé, Silva, George Allan, de Jesus, Michele Silva, Pessoa, Karina, Corado, André de Lima Guerra, Duarte, Debora Camila Gomes, Machado, Ana Beatriz, Zukeram, Ketiuce de Azevedo, Valente, Natalia, Lopes, Renata Serrano, Pereira, Elisa Cavalcante, Appolinario, Luciana Reis, Rocha, Alice Sampaio, Tort, Luis Fernando Lopez, Sekizuka, Tsuyoshi, Itokawa, Kentaro, Hashino, Masanori, Kuroda, Makoto, Dezordi, Filipe Zimmer, Wallau, Gabriel Luz, Delatorre, Edson, Gräf, Tiago, Siqueira, Marilda Mendonça, Bello, Gonzalo, and Resende, Paola Cristina

Published
2023
Full Text
View/download PDF

12. Out-of-Season Influenza during a COVID-19 Void in the State of Rio de Janeiro, Brazil: Temperature Matters

Author

Nott, Rohini, Fuller, Trevon L, Brasil, Patrícia, and Nielsen-Saines, Karin

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biodefense, Vaccine Related, Infectious Diseases, Immunization, Prevention, Emerging Infectious Diseases, Pneumonia & Influenza, Influenza, Infection, Good Health and Well Being, COVID-19 pandemic, Rio de Janeiro influenza epidemic, climate change, replicative advantage, out-of-season influenza, influenza epidemic, Clinical sciences, Immunology, Medical microbiology
Abstract

An out-of-season H3N2 type A influenza epidemic occurred in the State of Rio de Janeiro, Brazil during October-November 2021, in between the Delta and Omicron SARS-CoV-2 surges, which occurred in July-October 2021 and January-April 2022, respectively. We assessed the contribution of climate change and influenza immunization coverage in this unique, little publicized phenomenon. State weather patterns during the influenza epidemic were significantly different from the five preceding years, matching typical winter temperatures, associated with the out-of-season influenza. We also found a mismatch between influenza vaccine strains used in the winter of 2021 (trivalent vaccine with two type A strains (Victoria/2570/2019 H1N1, Hong Kong/2671/2019 H3N2) and one type B strain (Washington/02/2019, wild type) and the circulating influenza strain responsible for the epidemic (H3N2 Darwin type A influenza strain). In addition, in 2021, there was poor influenza vaccine coverage with only 56% of the population over 6 months old immunized. Amid the COVID-19 pandemic, we should be prepared for out-of-season outbreaks of other respiratory viruses in periods of COVID-19 remission, which underscore novel disease dynamics in the pandemic era. The availability of year-round influenza vaccines could help avoid unnecessary morbidity and mortality given that antibodies rapidly wane. Moreover, this would enable unimmunized individuals to have additional opportunities to vaccinate during out-of-season outbreaks.

Published
2022

13. Predictors of chronic joint pain after Chikungunya virus infection in the INOVACHIK prospective cohort study

Author

Martins, Ezequias B., Quintana, Marcel S.B., Silva, Michele F.B., de Bruycker-Nogueira, Fernanda, Moraes, Isabella C.V., Rodrigues, Cintia D.S., Santos, Carolina C., Sampaio, Simone A., Pina-Costa, Anielle, Fabri, Allison A., Guerra-Campos, Vinícius, Faria, Nieli R.C., Filippis, Ana Maria B., Brasil, Patrícia, and Calvet, Guilherme A.

Published
2023
Full Text
View/download PDF

15. Zika virus vertical transmission in children with confirmed antenatal exposure.

Author

Brasil, Patrícia, Vasconcelos, Zilton, Kerin, Tara, Gabaglia, Claudia Raja, Ribeiro, Ieda P, Bonaldo, Myrna C, Damasceno, Luana, Pone, Marcos V, Pone, Sheila, Zin, Andrea, Tsui, Irena, Adachi, Kristina, Pereira, Jose Paulo, Gaw, Stephanie L, Carvalho, Liege, Cunha, Denise C, Guida, Leticia, Rocha, Mirza, Cherry, James D, Wang, Lulan, Aliyari, Saba, Cheng, Genhong, Foo, Suan-Sin, Chen, Weiqiang, Jung, Jae, Brickley, Elizabeth, Moreira, Maria Elisabeth L, and Nielsen-Saines, Karin

Subjects
Humans, Communicable Diseases, Virus Diseases, Immunoglobulin M, Polymerase Chain Reaction, Pregnancy, Female, Zika Virus, Zika Virus Infection
Abstract

We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015-2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities.

Published
2020

16. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Author

Hasan, Zabir, Wanderley Lopes Gomes, Kilma, Soares Mesquita, Lyvia Patricia, Braga, Cynthia, Castanha, Priscila M.S., Cordeiro, Marli T., Damasceno, Luana, Chuop, Bophal, Ouk, Sonyrath, Sin, Reaksmey, Sun, Sopheary, Alvarez Vera, Mayling, Barahona, Guillermo, Cruz, Bladimir, Beck, Dorothea, Gaczkowski, Roger, Junghanss, Thomas, Morales, Ivonne, Wirths, Marius, Natkunam, Santha Kumari, Ho, Bee Kiau, AbuBakar, Sazaly, Abd-Jamil, Juraina, Syed Omar, Sharifah Faridah, Lizarazo, Erley F., Vincenti-González, María F., Tovar, Robert, Cao Thi, Tam, Dinh Thi Tri, Hong, Huynh Le Anh, Huy, Huynh Thi Le, Duyen, Lai Thi Cong, Thanh, Nguyen Thi Hong, Van, Nguyen Thi My, Linh, Tran Thi Nhu, Thuy, Truong Thi Thu, Thuy, Banh Thi, Nuoi, Huynh Lam Thuy, Trinh, Nguyen Thi Thu, Hiep, Tran Thi Kim, Van, Vo Thanh, Luan, Dang Thi, Bich, Dinh Thi Thu, Huong, Dinh Van, Huy, Nguyen Nguyen, Huyen, Vu Thi Thu, Huong, Rosenberger, Kerstin D, Phung Khanh, Lam, Tobian, Frank, Chanpheaktra, Ngoun, Kumar, Varun, Lum, Lucy Chai See, Sathar, Jameela, Pleités Sandoval, Ernesto, Marón, Gabriela M, Laksono, Ida Safitri, Mahendradhata, Yodi, Sarker, Malabika, Rahman, Ridwanur, Caprara, Andrea, Souza Benevides, Bruno, Marques, Ernesto T A, Magalhaes, Tereza, Brasil, Patrícia, Amaral Calvet, Guilherme, Tami, Adriana, Bethencourt, Sarah E, Dong Thi Hoai, Tam, Nguyen Tan Thanh, Kieu, Tran Van, Ngoc, Nguyen Tran, Nam, Do Chau, Viet, Yacoub, Sophie, Nguyen Van, Kinh, Guzmán, María G, Martinez, Pedro A, Nguyen Than Ha, Quyen, Simmons, Cameron P, Wills, Bridget A, Geskus, Ronald B, and Jaenisch, Thomas

Published
2023
Full Text
View/download PDF

17. Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children

Author

Nielsen-Saines, Karin, Brasil, Patrícia, Kerin, Tara, Vasconcelos, Zilton, Gabaglia, Claudia Raja, Damasceno, Luana, Pone, Marcos, Abreu de Carvalho, Liege M, Pone, Sheila M, Zin, Andrea A, Tsui, Irena, Salles, Tania Regina S, da Cunha, Denise Cotrim, Costa, Roozemerie Pereira, Malacarne, Jociele, Reis, Ana Beatriz, Hasue, Renata Hydee, Aizawa, Carolina YP, Genovesi, Fernanda F, Einspieler, Christa, Marschik, Peter B, Pereira, José Paulo, Gaw, Stephanie L, Adachi, Kristina, Cherry, James D, Xu, Zhiheng, Cheng, Genhong, and Moreira, Maria Elisabeth

Subjects
Paediatrics, Biomedical and Clinical Sciences, Intellectual and Developmental Disabilities (IDD), Brain Disorders, Clinical Research, Congenital Structural Anomalies, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Neurosciences, Mental Health, Pediatric Research Initiative, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Adult, Autism Spectrum Disorder, Child, Preschool, Female, Hearing, Humans, Infant, Infant, Newborn, Male, Microcephaly, Neurodevelopmental Disorders, Pregnancy, Pregnancy Complications, Infectious, Prospective Studies, Sensation Disorders, Vision, Ocular, Zika Virus Infection, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences
Abstract

We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015-2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = 137) and hearing assessments (n = 114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32 months of age. Among children assessed by Bayley-III, 12% scored below -2 s.d. (score

Published
2019

19. Myopericarditis associated with acute Zika virus infection: a case report

Author

Bôtto-Menezes, Camila Helena Aguiar, Safe, Izabella Picinin, da Cunha Ferreira, Ana Cláudia, do Nascimento Couceiro, Katia, Neto, Armando Menezes, Franca, Rafael Freitas Oliveira, Calvet, Guilherme Amaral, de Filippis, Ana Maria Bispo, Kara, Edna Oliveira, da Costa Castilho, Marcia, Bastos, Michele Souza, de Brito, Carlos Alexandre Antunes, Modjarrad, Kayvon, Broutet, Nathalie Jeanne Nicole, Brasil, Patrícia, Hajjar, Ludhmila Abrahão, and de Lacerda, Marcus Vinícius Guimarães

Published
2022
Full Text
View/download PDF

21. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2

Author

Foo, Suan-Sin, Cambou, Mary Catherine, Mok, Thalia, Fajardo, Viviana M., Jung, Kyle L., Fuller, Trevon, Chen, Weiqiang, Kerin, Tara, Mei, Jenny, Bhattacharya, Debika, Choi, Younho, Wu, Xin, Xia, Tian, Shin, Woo-Jin, Cranston, Jessica, Aldrovandi, Grace, Tobin, Nicole, Contreras, Deisy, Ibarrondo, Francisco J., Yang, Otto, Yang, Shangxin, Garner, Omai, Cortado, Ruth, Bryson, Yvonne, Janzen, Carla, Ghosh, Shubhamoy, Devaskar, Sherin, Asilnejad, Brenda, Moreira, Maria Elisabeth, Vasconcelos, Zilton, Soni, Priya R., Gibson, L. Caroline, Brasil, Patricia, Comhair, Suzy A.A., Arumugaswami, Vaithilingaraja, Erzurum, Serpil C., Rao, Rashmi, Jung, Jae U., and Nielsen-Saines, Karin

Published
2021
Full Text
View/download PDF

22. Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites?

Author

Abreu-Fernandes, Rebecca de, primary, Almeida-de-Oliveira, Natália Ketrin, additional, de Lavigne Mello, Aline Rosa, additional, Queiroz, Lucas Tavares de, additional, Barros, Jacqueline de Aguiar, additional, Baptista, Bárbara de Oliveira, additional, Oliveira-Ferreira, Joseli, additional, Souza, Rodrigo Medeiros de, additional, Pratt-Riccio, Lilian Rose, additional, Brasil, Patrícia, additional, Daniel-Ribeiro, Cláudio Tadeu, additional, and Ferreira-da-Cruz, Maria de Fátima, additional

Published
2024
Full Text
View/download PDF

23. A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014–2018)

Author

de Aguiar, Daniele Fernandes, de Barros, Eliana Nogueira C, Ribeiro, Guilherme Sousa, Brasil, Patricia, Mourao, Maria Paula Gomes, Luz, Kleber, Aoki, Francisco Hideo, Freitas, Andre Ricardo Ribas, Calvet, Guilherme Amaral, Oliveira, Eduardo, Branco, Bianca F, Abreu, Ariane, Cheuvart, Brigitte, Guignard, Adrienne, de Boer, Melanie, Duarte, Ana Claudia, Borges, Maria Beatriz, and de Noronha, Tatiana Guimarães

Published
2021
Full Text
View/download PDF

24. Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16.

Author

Fuller, Trevon L, Calvet, Guilherme, Genaro Estevam, Camila, Rafael Angelo, Jussara, Abiodun, Gbenga J, Halai, Umme-Aiman, De Santis, Bianca, Carvalho Sequeira, Patricia, Machado Araujo, Eliane, Alves Sampaio, Simone, Lima de Mendonça, Marco Cesar, Fabri, Allison, Ribeiro, Rita Maria, Harrigan, Ryan, Smith, Thomas B, Raja Gabaglia, Claudia, Brasil, Patrícia, Bispo de Filippis, Ana Maria, and Nielsen-Saines, Karin

Subjects
Animals, Humans, Dengue Virus, Chikungunya virus, Incidence, Risk Factors, Behavior, Climate, Rain, Disease Outbreaks, Pregnancy, Adult, Brazil, Female, Male, Young Adult, Chikungunya Fever, Zika Virus, Zika Virus Infection, Mosquito Vectors, General Science & Technology
Abstract

The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics. Further, we assessed the spatial pattern of arbovirus incidence at the municipal and neighborhood scales and the timing of epidemics and major rainfall events. Lab-confirmed cases included 1,717 infections with ZIKV (43.8%) and 2,170 with CHIKV (55.4%) and only 29 (

Published
2017

26. ALTERAÇÕES TRANSCRICIONAIS PRECOCEMENTE ENVOLVIDAS NA PROGRESSÃO DE PACIENTES PARA DOENÇA ARTICULAR CRÔNICA PÓS-CHIKUNGUNYA

Author

Ramundo, Mariana Severo, primary, da Fonseca, Guilherme Cordenonsi, additional, Gerber, Alexandra L., additional, Guimarães, Ana Paula, additional, Manuli, Erika Regina, additional, Côrtes, Marina Farrel, additional, Pereira, Geovana Maria, additional, Brustolini, Otavio, additional, Brasil, Patrícia, additional, Nakaya, Helder I., additional, Paranhos-Baccalà, Gláucia, additional, Vasconcelos, Ana Tereza R., additional, and Sabino, Ester Cerdeira, additional

Published
2023
Full Text
View/download PDF

27. Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

Author

de Pina-Costa, Anielle, Silvino, Ana Carolina Rios, dos Santos, Edwiges Motta, Pedro, Renata Saraiva, Moreira, José, Umana, Gabriela Liseth, da Silva, Ana Danielle Tavares, da Rosa Santos, Otília Helena Lupi, de Deus Henriques, Karina Medeiros, Daniel-Ribeiro, Cláudio Tadeu, Brasil, Patrícia, Sousa, Tais Nobrega, and Siqueira, André M.

Published
2021
Full Text
View/download PDF

28. The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching

Author

Mourier, Tobias, de Alvarenga, Denise Anete Madureira, Kaushik, Abhinav, de Pina-Costa, Anielle, Douvropoulou, Olga, Guan, Qingtian, Guzmán-Vega, Francisco J., Forrester, Sarah, de Abreu, Filipe Vieira Santos, Júnior, Cesare Bianco, de Souza Junior, Julio Cesar, Moreira, Silvia Bahadian, Hirano, Zelinda Maria Braga, Pissinatti, Alcides, Ferreira-da-Cruz, Maria de Fátima, de Oliveira, Ricardo Lourenço, Arold, Stefan T., Jeffares, Daniel C., Brasil, Patrícia, de Brito, Cristiana Ferreira Alves, Culleton, Richard, Daniel-Ribeiro, Cláudio Tadeu, and Pain, Arnab

Published
2021
Full Text
View/download PDF

29. Familiar barriers still unresolved—a perspective on the Zika virus outbreak research response

Author

Rosenberger, Kerstin D, Morales, Ivonne, Marques, Ernesto T A, Viana, Isabelle F T, Brasil, Patricia, Rabello, Renata, Avelino-Silva, Vivian I, Segurado, Aluisio, Alexander, Neal, Mayaud, Philippe, Netto, Eduardo Martins, Tami, Adriana, Bethencourt, Sarah, Consuelo Miranda, Maria, Lozano, Anyela, Soria, Carmen, Salgado Cisneros, Silvia Paula, Gotuzzo, Eduardo, Guzmán, María G, Rodriguez, Pedro A M, Lopez-Gatell, Hugo, Hegewisch-Taylor, Jennifer, Borja-Aburto, Victor Hugo, Gonzales Bonilla, Cesar, Hoen, Bruno, van Roode, Martine, Rockx, Barry, Koopmans, Marion, de Lamballerie, Xavier, and Jaenisch, Thomas

Published
2019
Full Text
View/download PDF

30. Visual function in infants with antenatal Zika virus exposure

Author

Zin, Andrea A., Tsui, Irena, Rossetto, Julia D., Gaw, Stephanie L., Neves, Luiza M., Zin, Olivia A., Haefeli, Lorena, Barros Silveira Filho, Joel Carlos, Adachi, Kristina, Vinicius da Silva Pone, Marcos, Pone, Sheila Moura, Molleri, Natalia, Pereira, Jose Paulo, Jr., Belfort, Rubens, Arumugaswami, Vaithilingaraja, Vasconcelos, Zilton, Brasil, Patricia, Nielsen-Saines, Karin, and Lopes Moreira, Maria Elisabeth

Published
2018
Full Text
View/download PDF

31. Malaria mitochondrial diagnosis: challenges and pitfalls

Author

Costa, Gabriel Luíz, primary, Alvarenga, Denise Anete Madureira de, additional, Assis, Gabriela Maíra Pereira de, additional, Aguiar, Anna Caroline Campos, additional, Louzada, Jaime, additional, Pereira, Dhélio Batista, additional, Pina-Costa, Anielle de, additional, Hirano, Zelinda Maria Braga, additional, Moreira, Sílvia Bahadian, additional, Pissinatti, Alcides, additional, Brasil, Patrícia, additional, Daniel-Ribeiro, Cláudio Tadeu, additional, Sousa, Taís Nóbrega de, additional, and Alves de Brito, Cristiana Ferreira, additional

Published
2023
Full Text
View/download PDF

33. Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation

Author

Brasil, Patrícia, Zalis, Mariano Gustavo, de Pina-Costa, Anielle, Siqueira, Andre Machado, Júnior, Cesare Bianco, Silva, Sidnei, Areas, André Luiz Lisboa, Pelajo-Machado, Marcelo, de Alvarenga, Denise Anete Madureira, da Silva Santelli, Ana Carolina Faria, Albuquerque, Hermano Gomes, Cravo, Pedro, Santos de Abreu, Filipe Vieira, Peterka, Cassio Leonel, Zanini, Graziela Maria, Suárez Mutis, Martha Cecilia, Pissinatti, Alcides, Lourenço-de-Oliveira, Ricardo, de Brito, Cristiana Ferreira Alves, de Fátima Ferreira-da-Cruz, Maria, Culleton, Richard, and Daniel-Ribeiro, Cláudio Tadeu

Published
2017
Full Text
View/download PDF

36. Plasmodium falciparum Chloroquine-pfcrt Resistant Haplotypes in Brazilian Endemic Areas Four Decades after CQ Withdrawn

Author

de Abreu-Fernandes, Rebecca, primary, Almeida-de-Oliveira, Natália Ketrin, additional, Gama, Bianca Ervatti, additional, Gomes, Larissa Rodrigues, additional, De Lavigne Mello, Aline Rosa, additional, Queiroz, Lucas Tavares de, additional, Barros, Jacqueline de Aguiar, additional, Alecrim, Maria das Graças Costa, additional, Medeiros de Souza, Rodrigo, additional, Pratt-Riccio, Lilian Rose, additional, Brasil, Patrícia, additional, Daniel-Ribeiro, Cláudio Tadeu, additional, and Ferreira-da-Cruz, Maria de Fátima, additional

Published
2023
Full Text
View/download PDF

39. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance

Author

Bressan, Clarisse da Silveira, primary, Teixeira, Maria de Lourdes Benamor, additional, Gouvêa, Maria Isabel Fragoso da Silveira, additional, de Pina-Costa, Anielle, additional, Santos, Heloísa Ferreira Pinto, additional, Calvet, Guilherme Amaral, additional, Lupi, Otilia, additional, Siqueira, Andre Machado, additional, Valls-de-Souza, Rogério, additional, Valim, Clarissa, additional, and Brasil, Patrícia, additional

Published
2023
Full Text
View/download PDF

44. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study

Author

Rosenberger, Kerstin D, primary, Phung Khanh, Lam, additional, Tobian, Frank, additional, Chanpheaktra, Ngoun, additional, Kumar, Varun, additional, Lum, Lucy Chai See, additional, Sathar, Jameela, additional, Pleités Sandoval, Ernesto, additional, Marón, Gabriela M, additional, Laksono, Ida Safitri, additional, Mahendradhata, Yodi, additional, Sarker, Malabika, additional, Rahman, Ridwanur, additional, Caprara, Andrea, additional, Souza Benevides, Bruno, additional, Marques, Ernesto T A, additional, Magalhaes, Tereza, additional, Brasil, Patrícia, additional, Amaral Calvet, Guilherme, additional, Tami, Adriana, additional, Bethencourt, Sarah E, additional, Dong Thi Hoai, Tam, additional, Nguyen Tan Thanh, Kieu, additional, Tran Van, Ngoc, additional, Nguyen Tran, Nam, additional, Do Chau, Viet, additional, Yacoub, Sophie, additional, Nguyen Van, Kinh, additional, Guzmán, María G, additional, Martinez, Pedro A, additional, Nguyen Than Ha, Quyen, additional, Simmons, Cameron P, additional, Wills, Bridget A, additional, Geskus, Ronald B, additional, Jaenisch, Thomas, additional, Hasan, Zabir, additional, Wanderley Lopes Gomes, Kilma, additional, Soares Mesquita, Lyvia Patricia, additional, Braga, Cynthia, additional, Castanha, Priscila M.S., additional, Cordeiro, Marli T., additional, Damasceno, Luana, additional, Chuop, Bophal, additional, Ouk, Sonyrath, additional, Sin, Reaksmey, additional, Sun, Sopheary, additional, Alvarez Vera, Mayling, additional, Barahona, Guillermo, additional, Cruz, Bladimir, additional, Beck, Dorothea, additional, Gaczkowski, Roger, additional, Junghanss, Thomas, additional, Morales, Ivonne, additional, Wirths, Marius, additional, Natkunam, Santha Kumari, additional, Ho, Bee Kiau, additional, AbuBakar, Sazaly, additional, Abd-Jamil, Juraina, additional, Syed Omar, Sharifah Faridah, additional, Lizarazo, Erley F., additional, Vincenti-González, María F., additional, Tovar, Robert, additional, Cao Thi, Tam, additional, Dinh Thi Tri, Hong, additional, Huynh Le Anh, Huy, additional, Huynh Thi Le, Duyen, additional, Lai Thi Cong, Thanh, additional, Nguyen Thi Hong, Van, additional, Nguyen Thi My, Linh, additional, Tran Thi Nhu, Thuy, additional, Truong Thi Thu, Thuy, additional, Banh Thi, Nuoi, additional, Huynh Lam Thuy, Trinh, additional, Nguyen Thi Thu, Hiep, additional, Tran Thi Kim, Van, additional, Vo Thanh, Luan, additional, Dang Thi, Bich, additional, Dinh Thi Thu, Huong, additional, Dinh Van, Huy, additional, Nguyen Nguyen, Huyen, additional, and Vu Thi Thu, Huong, additional

Published
2023
Full Text
View/download PDF

47. Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort

Author

Lázari, Carolina dos Santos, primary, Ramundo, Mariana Severo, additional, ten-Caten, Felipe, additional, Bressan, Clarisse S., additional, de Filippis, Ana Maria Bispo, additional, Manuli, Erika Regina, additional, de Moraes, Isabella, additional, Pereira, Geovana Maria, additional, Côrtes, Marina Farrel, additional, Candido, Darlan da Silva, additional, Gerber, Alexandra L., additional, Guimarães, Ana Paula, additional, Faria, Nuno Rodrigues, additional, Nakaya, Helder I., additional, Vasconcelos, Ana Tereza R., additional, Brasil, Patrícia, additional, Paranhos-Baccalà, Gláucia, additional, and Sabino, Ester Cerdeira, additional

Published
2023
Full Text
View/download PDF

48. Risk of adverse outcomes in offspring with RT-PCR confirmed prenatal Zika virus exposure: an individual participant data meta-analysis of 13 cohorts in the Zika Brazilian Cohorts Consortium

Author

Arraes de Alencar Ximenes, Ricardo, primary, de Barros Miranda-Filho, Demócrito, additional, Brickley, Elizabeth B., additional, Barreto de Araújo, Thalia Velho, additional, Montarroyos, Ulisses Ramos, additional, Abtibol-Bernardino, Marília Rosa, additional, Mussi-Pinhata, Marisa M., additional, Duarte, Geraldo, additional, Coutinho, Conrado Milani, additional, Biason de Moura Negrini, Silvia Fabiana, additional, Alecrim, Maria das Graças Costa, additional, Albuquerque de Almeida Peixoto, Lucíola de Fátima, additional, Lopes Moreira, Maria Elisabeth, additional, Zin, Andrea, additional, Pereira Júnior, José Paulo, additional, Nielsen-Saines, Karin, additional, Turchi Martelli, Celina Maria, additional, Rodrigues, Laura Cunha, additional, Vieira de Souza, Wayner, additional, Ventura, Liana O., additional, Silva de Oliveira, Consuelo, additional, de Matos, Haroldo, additional, Furtado Serra, Emilene Monteiro, additional, Souza Gomes, Luna Thais, additional, Nogueira, Maurício L., additional, Estofolete, Cassia, additional, Vaz-Oliani, Denise Cristina, additional, Passos, Saulo Duarte, additional, Moron, Antonio, additional, Duarte Rodrigues, Maria Manoela, additional, Pereira Sarmento, Stéphanno Gomes, additional, Turchi, Marília Dalva, additional, Pela Rosado, Luiza Emylce, additional, de Sene Amâncio Zara, Ana Laura, additional, Franco Gomes, Maria Bárbara, additional, Schuler-Faccini, Lavínia, additional, Herrero-Silva, Juliana, additional, Amorim, Melania M., additional, Melo, Adriana Oliveira, additional, Ledo Alves da Cunha, Antônio José, additional, Prata-Barbosa, Arnaldo, additional, Amim, Joffre, additional, Rezende-Filho, Jorge, additional, Calcagno, Juan Ignacio, additional, Júnior Alcântara, Luiz Carlos, additional, Lima de Almeida, Breno, additional, Hofer, Cristina Barroso, additional, Machado, Elizabeth S., additional, de Siqueira, Isadora Cristina, additional, Martinez-Espinosa, Flor Ernestina, additional, Brasil, Patrícia, additional, de Carvalho Leal, Mariana, additional, de Albuquerque, Maria de Fátima Pessoa Militão, additional, Malacarne, Jociele, additional, Damasceno, Luana, additional, de Filippis, Ana Maria Bispo, additional, Santos, Cleiton Silva, additional, Duarte, Alan Oliveira, additional, Vasconcelos, Pedro Fernando, additional, Machado, Mariana Borges, additional, Bertozzi, Ana paula Antunes Pascalicchio, additional, Gillo Fajardo, Thamirys Cosmo, additional, Tiraboschi Bárbaro, Adriana Aparecida, additional, Marçal Assef, Ligia Conceição, additional, Pimentel, Clarice, additional, Abreu, Thalita, additional, de Sales Tavares, Jousilene, additional, de Oliveira Melo, Fabiana, additional, de Toledo Lima, Talita, additional, Brasil, Maria das Graças Nunes, additional, Terças-Trettel, Cláudia Pereira, additional, de Araújo França, Giovanny Vinícius, additional, Aguiar Bôtto-Menezes, Camila Helena, additional, Benzecry, Silvana Gomes, additional, Robaina, Jaqueline Rodrigues, additional, and de Oliveira, Mariana Barros Genuíno, additional

Published
2023
Full Text
View/download PDF

49. Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report

Author

Espíndola, Otávio, primary, Resende, Paola C, additional, Guaraldo, Lusiele, additional, Calvet, Guilherme Amaral, additional, Fuller, Trevon L, additional, Penetra, Stephanie Lema Suarez, additional, Santos, Heloisa Ferreira Pinto, additional, Pina-Costa, Anielle, additional, da Silva, Michele Fernanda Borges, additional, Moraes, Isabella Campos Vargas, additional, Medeiros, Fernando, additional, Whitworth, Jimmy, additional, Smith, Christopher, additional, Nielsen-Saines, Karin, additional, Siqueira, Marilda M, additional, and Brasil, Patrícia, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results