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2. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update.

Author

Klompas, Michael, Branson, Richard, Cawcutt, Kelly, Crist, Matthew, Eichenwald, Eric, Greene, Linda, Lee, Grace, Maragakis, Lisa, Powell, Krista, Priebe, Gregory, Speck, Kathleen, Berenholtz, Sean, and Yokoe, Deborah

Subjects
Adult, Child, Cross Infection, Healthcare-Associated Pneumonia, Hospitals, Humans, Infant, Newborn, Infection Control, Pneumonia, Pneumonia, Ventilator-Associated, Ventilators, Mechanical
Abstract

The purpose of this document is to highlight practical recommendations to assist acute care hospitals to prioritize and implement strategies to prevent ventilator-associated pneumonia (VAP), ventilator-associated events (VAE), and non-ventilator hospital-acquired pneumonia (NV-HAP) in adults, children, and neonates. This document updates the Strategies to Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals published in 2014. This expert guidance document is sponsored by the Society for Healthcare Epidemiology (SHEA), and is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America, the American Hospital Association, the Association for Professionals in Infection Control and Epidemiology, and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise.

Published
2022

4. Optimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Mokhlesi, Babak, Won, Christine H, Make, Barry J, Selim, Bernardo J, Sunwoo, Bernie Y, Panel, ONMAP Technical Expert, Gay, Peter C, Owens, Robert L, Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi S, Coleman, John M, Hess, Dean R, Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc I, Collop, Nancy A, Patil, Susheel P, Chediak, Alejandro D, Olson, Eric J, and Vohra, Kunwar Praveen

Subjects
Sleep Research, Clinical Research, Clinical Trials and Supportive Activities, Aging, Lung, Good Health and Well Being, Continuous Positive Airway Pressure, Health Services Accessibility, Home Care Services, Humans, Hypoventilation, Medicare, Noninvasive Ventilation, Oxygen, Patient Discharge, Polysomnography, Pulmonary Medicine, Respiration Disorders, Spirometry, United States, Bilevel PAP, CPAP, home mechanical ventilator, noninvasive ventilation, obesity hypoventilation, volume assured pressure support, ONMAP Technical Expert Panel, Clinical Sciences, Respiratory System
Abstract

The existing coverage criteria for home noninvasive ventilation (NIV) do not recognize the diversity of hypoventilation syndromes and advances in technologies. This document summarizes the work of the hypoventilation syndromes Technical Expert Panel working group. The most pressing current coverage barriers identified were: (1) overreliance on arterial blood gases (particularly during sleep); (2) need to perform testing on prescribed oxygen; (3) requiring a sleep study to rule out OSA as the cause of sustained hypoxemia; (4) need for spirometry; (5) need to show bilevel positive airway pressure (BPAP) without a backup rate failure to qualify for BPAP spontaneous/timed; and (6) qualifying hospitalized patients for home NIV therapy at the time of discharge. Critical evidence support for changes to current policies includes randomized controlled trial evidence and clinical practice guidelines. To decrease morbidity and mortality by achieving timely access to NIV for patients with hypoventilation, particularly those with obesity hypoventilation syndrome, we make the following key suggestions: (1) given the significant technological advances, we advise acceptance of surrogate noninvasive end-tidal and transcutaneous Pco2 and venous blood gases in lieu of arterial blood gases; (2) not requiring Pco2 measures while on prescribed oxygen; (3) not requiring a sleep study to avoid delays in care in patients being discharged from the hospital; (4) remove spirometry as a requirement; and (5) not requiring BPAP without a backup rate failure to approve BPAP spontaneous/timed. The overarching goal of the Technical Expert Panel is to establish pathways that improve clinicians' management capability to provide Medicare beneficiaries access to appropriate home NIV therapy. Adoption of these proposed suggestions would result in the right device, for the right type of patient with hypoventilation syndromes, at the right time.

Published
2021

5. Optimal NIV Medicare Access Promotion: Patients With Central Sleep Apnea A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc, Panel, ONMAP Technical Expert, Gay, Peter C, Owens, Robert L, Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi S, Coleman, John M, Hess, Dean R, Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Raphaelson, Marc I, Mokhlesi, Babak, Won, Christine H, Selim, Bernardo J, Make, Barry J, Sunwoo, Bernie Y, Collop, Nancy A, Patil, Susheel P, Chediak, Alejandro D, Olson, Eric J, and Vohra, Kunwar Praveen

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Bioengineering, Sleep Research, Continuous Positive Airway Pressure, Humans, Hypoxia, Medicare, Noninvasive Ventilation, Oxygen Inhalation Therapy, Patient Selection, Sleep Apnea, Central, Time-to-Treatment, United States, central sleep apnea, CPAP, noninvasive ventilation, oxygen, ONMAP Technical Expert Panel, Clinical Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

This document summarizes suggestions of the central sleep apnea (CSA) Technical Expert Panel working group. This paper shares our vision for bringing the right device to the right patient at the right time. For patients with CSA, current coverage criteria do not align with guideline treatment recommendations. For example, CPAP and oxygen therapy are recommended but not covered for CSA. On the other hand, bilevel positive airway pressure (BPAP) without a backup rate may be a covered therapy for OSA, but it may worsen CSA. Narrow coverage criteria that require near elimination of obstructive breathing events on CPAP or BPAP in the spontaneous mode, even if at poorly tolerated pressure levels, may preclude therapy with BPAP with backup rate or adaptive servoventilation, even when those devices provide demonstrably better therapy. CSA is a dynamic disorder that may require different treatments over time, sometimes switching from one device to another; an example is switching from BPAP with backup rate to an adaptive servoventilation with automatic end-expiratory pressure adjustments, which may not be covered. To address these challenges, we suggest several changes to the coverage determinations, including: (1) a single simplified initial and continuing coverage definition of CSA that aligns with OSA; (2) removal of hypoventilation terminology from coverage criteria for CSA; (3) all effective therapies for CSA should be covered, including oxygen and all PAP devices with or without backup rates or servo-mechanisms; and (4) patients shown to have a suboptimal response to one PAP device should be allowed to add oxygen or change to another PAP device with different capabilities if shown to be effective with testing.

Published
2021

6. Executive Summary Optimal NIV Medicare Access Promotion: A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Gay, Peter C, Owens, Robert L, Panel, ONMAP Technical Expert, Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi S, Coleman, John M, Hess, Dean R, Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc I, Mokhlesi, Babak, Won, Christine H, Selim, Bernardo J, Make, Barry J, Sunwoo, Bernie Y, Collop, Nancy A, Patil, Susheel P, Chediak, Alejandro D, Olson, Eric J, and Vohra, Kunwar Praveen

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Sleep Research, Respiratory, Benchmarking, Consensus, Humans, Medicare, Noninvasive Ventilation, Patient Selection, Respiration Disorders, United States, access, noninvasive, optimal, ventilation, ONMAP Technical Expert Panel, Clinical Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

The current national coverage determinations (NCDs) for noninvasive ventilation for patients with thoracic restrictive disorders, COPD, and hypoventilation syndromes were formulated in 1998. New original research, updated formal practice guidelines, and current consensus expert opinion have accrued that are in conflict with the existing NCDs. Some inconsistencies in the NCDs have been noted, and the diagnostic and therapeutic technology has also advanced in the last quarter century. Thus, these and related NCDs relevant to bilevel positive airway pressure for the treatment of OSA and central sleep apnea need to be updated to ensure the optimal health of patients with these disorders. To that end, the American College of Chest Physicians organized a multisociety (American Thoracic Society, American Academy of Sleep Medicine, and American Association for Respiratory Care) effort to engage experts in the field to: (1) identify current barriers to optimal care; (2) highlight compelling scientific evidence that would justify changes from current policies incorporating best evidence and practice; and (3) propose suggestions that would form the basis for a revised NCD in each of these 5 areas (thoracic restrictive disorders, COPD, hypoventilation syndromes, OSA, and central sleep apnea). The expert panel met during a 2-day virtual summit in October 2020 and subsequently crafted written documents designed to achieve provision of "the right device to the right patient at the right time." These documents have been endorsed by the participating societies following peer review and publication in CHEST and will be used to inform efforts to revise the current NCDs.

Published
2021

7. Optimal NIV Medicare Access Promotion: Patients With OSA A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Patil, Susheel P, Collop, Nancy A, Chediak, Alejandro D, Olson, Eric J, Vohra, Kunwar Praveen, Panel, ONMAP Technical Expert, Gay, Peter C, Owens, Robert L, Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi S, Coleman, John M, Hess, Dean R, Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc I, Mokhlesi, Babak, Won, Christine H, Selim, Bernardo J, Make, Barry J, and Sunwoo, Bernie Y

Subjects
Health Services, Lung, Clinical Research, Networking and Information Technology R&D (NITRD), Sleep Research, Humans, Hypoxia, Medicare, Patient Compliance, Patient Selection, Positive-Pressure Respiration, Quality of Life, Severity of Illness Index, Sleep Apnea, Obstructive, Symptom Assessment, Telemedicine, United States, ONMAP Technical Expert Panel, NIV, OSA, access, noninvasive ventilation, optimal, positive airway pressure, sleep apnea, Clinical Sciences, Respiratory System
Abstract

This document summarizes the work of the CPAP and bilevel PAP therapy for OSA Technical Expert Panel working group. For positive airway pressure (PAP) therapy, the most pressing current coverage barriers identified were: an insufficient symptom list describing all potential symptoms in patients with mild OSA; the 4 h per night of PAP usage requirement to keep the device; the additional sleep studies requirement to re-qualify for PAP or supplemental oxygen; and the inability to use telehealth visits for follow-up visits. Critical evidence supports changes to current policies and includes: symptom list inadequate to cover all scenarios based on updated clinical practice guidelines; published evidence that 2 h per night of PAP use can result in benefit to quality of life and other metrics; the costs of another sleep study not justified for all nonadherent patients or for supplemental oxygen due to other types of assessment currently available; and the remarkable success and acceptance of telehealth visits. To achieve optimal access for patients on PAP therapy, we make the following key suggestions: removing symptom criteria for mild OSA; reduce continued coverage criteria to > 2 h per night; eliminate the need for a sleep study to re-qualify if nonadherent or for new Centers for Medicare & Medicaid Services beneficiaries already on and adherent to PAP therapy; allow telehealth visits for documenting benefit and adherence; and allow PAP reports and domiciliary oximetry to qualify for supplemental oxygen with PAP if needed. This paper shares our best vision for bringing the right device to the right patient at the right time.

Published
2021

8. Optimal NIV Medicare Access Promotion: Patients With COPD A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Panel, ONMAP Technical Expert, Gay, Peter C, Owens, Robert L, Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi S, Coleman, John M, Hess, Dean R, Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc I, Mokhlesi, Babak, Won, Christine H, Selim, Bernardo J, Make, Barry J, Sunwoo, Bernie Y, Collop, Nancy A, Patil, Susheel P, Chediak, Alejandro D, Olson, Eric J, and Vohra, Kunwar Praveen

Subjects
Bioengineering, Clinical Research, Chronic Obstructive Pulmonary Disease, Assistive Technology, Clinical Trials and Supportive Activities, Lung, Respiratory, Good Health and Well Being, Airway Management, Continuous Positive Airway Pressure, Home Care Services, Humans, Medicare, Noninvasive Ventilation, Patient Participation, Patient Selection, Practice Guidelines as Topic, Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, United States, ONMAP Technical Expert Panel, COPD, hypercapnic respiratory failure, mechanical ventilation, noninvasive ventilation, Clinical Sciences, Respiratory System
Abstract

This document summarizes the work of the COPD Technical Expert Panel working group. For patients with COPD, the most pressing current coverage barriers identified were onerous diagnostic requirements focused on oxygenation (rather than ventilation) and difficulty obtaining bilevel devices with backup rate capabilities. Because of these difficulties, many patients with COPD were instead sometimes prescribed home mechanical ventilators. Critical evidence supports changes to current policies, including randomized controlled trial evidence suggesting a mortality benefit from bilevel positive airway pressure with backup rate and updated clinical practice guidelines from the American Thoracic Society as well as the European Respiratory Society. To achieve optimal access to noninvasive ventilation for patients with COPD, we make the following key recommendations: (1) removal of the need for overnight oximetry testing; (2) the ability to initiate therapy using bilevel devices with backup rate capability; and (3) increased duration of time to meet adherence criteria (ie, a second 90-day trial period) in those patients actively engaged in their care. Clear guidelines based on medical necessity are also included for patients who require initiation of or switch to a home mechanical ventilator. Adoption of these proposed recommendations would result in the right device, for the right type of patient with COPD, at the right time. Finally, we emphasize the need for adequate clinical support during initiation and maintenance of home noninvasive ventilation in such patients.

Published
2021

9. Optimal NIV Medicare Access Promotion: Patients With Thoracic Restrictive Disorders A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society

Author

Wolfe, Lisa F, Benditt, Joshua O, Aboussouan, Loutfi, Hess, Dean R, Coleman, John M, Panel, ONMAP Technical Expert, Gay, Peter C, Owens, Robert L, Aboussouan, Loutfi S, Hill, Nicholas S, Criner, Gerard J, Branson, Richard D, Celli, Bartolome R, MacIntyre, Neil R, Sergew, Amen, Morgenthaler, Timothy I, Malhotra, Atul, Berry, Richard B, Johnson, Karin G, Raphaelson, Marc I, Mokhlesi, Babak, Won, Christine H, Selim, Bernardo J, Make, Barry J, Sunwoo, Bernie Y, Collop, Nancy A, Patil, Susheel P, Chediak, Alejandro D, Olson, Eric J, and Vohra, Kunwar Praveen

Subjects
Assistive Technology, Patient Safety, Bioengineering, Lung, Respiratory, Blood Gas Analysis, Continuous Positive Airway Pressure, Home Care Services, Humans, Medicare, Neuromuscular Diseases, Noninvasive Ventilation, Patient Selection, Respiratory Insufficiency, Thoracic Diseases, United States, ONMAP Technical Expert Panel, neuromuscular, noninvasive, ventilations, Clinical Sciences, Respiratory System
Abstract

The existing coverage criteria for noninvasive ventilation (NIV) do not recognize the benefits of early initiation of NIV for those with thoracic restrictive disorders and do not address the unique needs for daytime support as the patients progress to ventilator dependence. This document summarizes the work of the thoracic restrictive disorder Technical Expert Panel working group. The most pressing current coverage barriers identified were: (1) delays in implementing NIV treatment; (2) lack of coverage for many nonprogressive neuromuscular diseases; and (3) lack of clear policy indications for home mechanical ventilation (HMV) support in thoracic restrictive disorders. To best address these issues, we make the following key recommendations: (1) given the need to encourage early initiation of NIV with bilevel positive airway pressure devices, we recommend that symptoms be considered as a reason to initiate therapy even at mildly reduced FVCs; (2) broaden CO2 measurements to include surrogates such as transcutaneous, end-tidal, or venous blood gas; (3) expand the diagnostic category to include phrenic nerve injuries and disorders of central drive; (4) allow a bilevel positive airway pressure device to be advanced to an HMV when the vital capacity is < 30% or to address severe daytime respiratory symptoms; and (5) provide additional HMV when the patient is ventilator dependent with use > 18 h per day. Adoption of these proposed recommendations would result in the right device, at the right time, for the right type of patients with thoracic restrictive disorders.

Published
2021

10. Acute respiratory distress syndrome, acute kidney injury, and mortality after trauma are associated with increased circulation of syndecan-1, soluble thrombomodulin, and receptor for advanced glycation end products

Author

Dixon, Alexandra, Kenny, James E., Buzzard, Lydia, Holcomb, John, Bulger, Eileen, Wade, Charles, Fabian, Timothy, Schreiber, Martin, Holcomb, John B., Wade, Charles E., del Junco, Deborah J., Fox, Erin E., Matijevic, Nena, Podbielski, Jeanette M., Beeler, Angela M., Tilley, Barbara C., Baraniuk, Sarah, DeSantis, Stacia M., Zhu, Hongjian, Nixon, Joshua, Seay, Roann, Appana, Savitri N., Yang, Hui, Gonzalez, Michael O., Baer, Lisa, Wang, Yao-Wei Willa, Hula, Brittany S., Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D., Sharma, Rishika, Cardenas, Jessica C., Rahbar, Elaheh, Burnett, Tyrone, Jr, Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P., Hess, John R., Callum, Jeannie L., Pittet, Jean-Francois, Miller, Christopher N., Cotton, Bryan A., Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G., Gumbert, Sam D., Bai, Yu, McCarthy, James J., Noland, Amy, Hobbs, Rhonda, Bulger, Eileen M., Klotz, Patricia, Cattin, Lindsay, Warner, Keir J., Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A., Cohen, Mitchell Jay, Callcut, Rachael A., Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P., Maxim, Preston C., Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A., Robinson, Bryce R. H., Branson, Richard D., Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M., Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G., Wong, Monica D., Menchine, Michael, Katzberg, Kelly, Henderson, Sean O., McKeever, Rodney, Shulman, Ira A., Nelson, Janice M., Tuma, Christopher W., Matsushita, Cheryl Y., Scalea, Thomas M., Stein, Deborah M., Shaffer, Cynthia K., Wade, Christine, Herrera, Anthony V., Kallam, Seeta, Wade, Sarah E., Galvagno, Samuel M., Jr, Fontaine, Magali J., Hunt, Janice M., Cooke, Rhonda K., Fabian, Timothy C., Weinberg, Jordan A., Croce, Martin A., Wilson, Suzanne, Panzer-Baggett, Stephanie, Waddle-Smith, Lynda, Flax, Sherri, Brasel, Karen J., Walsh, Pamela, Milia, David, Nelson, Allia, Kaslow, Olga, Aufderheide, Tom P., Gottschall, Jerome L., Carpenter, Erica, OʼKeeffe, Terence, Rokowski, Laurel L., Denninghoff, Kurt R., Redford, Daniel T., Novak, Deborah J., Knoll, Susan, Kerby, Jeffrey D., Bosarge, Patrick L., Pierce, Albert T., Williams, Carolyn R., Stephens, Shannon W., Wang, Henry E., Marques, Marisa B., Schreiber, Martin A., Watters, Jennifer M., Underwood, Samantha J., Groat, Tahnee, Newgard, Craig, Merkel, Matthias, Scanlan, Richard M., Miller, Beth, Rizoli, Sandro, Tien, Homer, Nascimento, Barto, Trpcic, Sandy, Sobrian-Couroux, Skeeta, Reis, Marciano, Pérez, Adic, Belo, Susan E., Merkley, Lisa, and Colavecchia, Connie

Published
2024
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11. Detecting Drift in Healthcare AI Models Based on Data Availability

Author

Rotalinti, Ylenia, Tucker, Allan, Lonergan, Michael, Myles, Puja, Branson, Richard, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Koprinska, Irena, editor, Mignone, Paolo, editor, Guidotti, Riccardo, editor, Jaroszewicz, Szymon, editor, Fröning, Holger, editor, Gullo, Francesco, editor, Ferreira, Pedro M., editor, Roqueiro, Damian, editor, Ceddia, Gaia, editor, Nowaczyk, Slawomir, editor, Gama, João, editor, Ribeiro, Rita, editor, Gavaldà, Ricard, editor, Masciari, Elio, editor, Ras, Zbigniew, editor, Ritacco, Ettore, editor, Naretto, Francesca, editor, Theissler, Andreas, editor, Biecek, Przemyslaw, editor, Verbeke, Wouter, editor, Schiele, Gregor, editor, Pernkopf, Franz, editor, Blott, Michaela, editor, Bordino, Ilaria, editor, Danesi, Ivan Luciano, editor, Ponti, Giovanni, editor, Severini, Lorenzo, editor, Appice, Annalisa, editor, Andresini, Giuseppina, editor, Medeiros, Ibéria, editor, Graça, Guilherme, editor, Cooper, Lee, editor, Ghazaleh, Naghmeh, editor, Richiardi, Jonas, editor, Saldana, Diego, editor, Sechidis, Konstantinos, editor, Canakoglu, Arif, editor, Pido, Sara, editor, Pinoli, Pietro, editor, Bifet, Albert, editor, and Pashami, Sepideh, editor

Published
2023
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12. Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline

Author

Macrea, Madalina, Oczkowski, Simon, Rochwerg, Bram, Branson, Richard D, Celli, Bartolome, Coleman, John M, Hess, Dean R, Knight, Shandra Lee, Ohar, Jill A, Orr, Jeremy E, Piper, Amanda J, Punjabi, Naresh M, Rahangdale, Shilpa, Wijkstra, Peter J, Yim-Yeh, Susie, Drummond, M Bradley, and Owens, Robert L

Subjects
Chronic Obstructive Pulmonary Disease, Prevention, Lung, Respiratory, Chronic Disease, Humans, Hypercapnia, Noninvasive Ventilation, Pulmonary Disease, Chronic Obstructive, Time Factors, chronic obstructive pulmonary disease, hypercapnic respiratory failure, noninvasive ventilation, Medical and Health Sciences, Respiratory System
Abstract

Background: Noninvasive ventilation (NIV) is used for patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. However, evidence for clinical efficacy and optimal management of therapy is limited.Target Audience: Patients with COPD, clinicians who care for them, and policy makers.Methods: We summarized evidence addressing five PICO (patients, intervention, comparator, and outcome) questions. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach was used to evaluate the certainty in evidence and generate actionable recommendations. Recommendations were formulated by a panel of pulmonary and sleep physicians, respiratory therapists, and methodologists using the Evidence-to-Decision framework.Recommendations: 1) We suggest the use of nocturnal NIV in addition to usual care for patients with chronic stable hypercapnic COPD (conditional recommendation, moderate certainty); 2) we suggest that patients with chronic stable hypercapnic COPD undergo screening for obstructive sleep apnea before initiation of long-term NIV (conditional recommendation, very low certainty); 3) we suggest not initiating long-term NIV during an admission for acute-on-chronic hypercapnic respiratory failure, favoring instead reassessment for NIV at 2-4 weeks after resolution (conditional recommendation, low certainty); 4) we suggest not using an in-laboratory overnight polysomnogram to titrate NIV in patients with chronic stable hypercapnic COPD who are initiating NIV (conditional recommendation, very low certainty); and 5) we suggest NIV with targeted normalization of PaCO2 in patients with hypercapnic COPD on long-term NIV (conditional recommendation, low certainty).Conclusions: This expert panel provides evidence-based recommendations addressing the use of NIV in patients with COPD and chronic stable hypercapnic respiratory failure.

Published
2020

13. Machine learning and AI research for Patient Benefit: 20 Critical Questions on Transparency, Replicability, Ethics and Effectiveness

Author

Vollmer, Sebastian, Mateen, Bilal A., Bohner, Gergo, Király, Franz J, Ghani, Rayid, Jonsson, Pall, Cumbers, Sarah, Jonas, Adrian, McAllister, Katherine S. L., Myles, Puja, Granger, David, Birse, Mark, Branson, Richard, Moons, Karel GM, Collins, Gary S, Ioannidis, John P. A., Holmes, Chris, and Hemingway, Harry

Subjects
Computer Science - Computers and Society, Computer Science - Machine Learning, Statistics - Applications, Statistics - Machine Learning, 68T01
Abstract

Machine learning (ML), artificial intelligence (AI) and other modern statistical methods are providing new opportunities to operationalize previously untapped and rapidly growing sources of data for patient benefit. Whilst there is a lot of promising research currently being undertaken, the literature as a whole lacks: transparency; clear reporting to facilitate replicability; exploration for potential ethical concerns; and, clear demonstrations of effectiveness. There are many reasons for why these issues exist, but one of the most important that we provide a preliminary solution for here is the current lack of ML/AI- specific best practice guidance. Although there is no consensus on what best practice looks in this field, we believe that interdisciplinary groups pursuing research and impact projects in the ML/AI for health domain would benefit from answering a series of questions based on the important issues that exist when undertaking work of this nature. Here we present 20 questions that span the entire project life cycle, from inception, data analysis, and model evaluation, to implementation, as a means to facilitate project planning and post-hoc (structured) independent evaluation. By beginning to answer these questions in different settings, we can start to understand what constitutes a good answer, and we expect that the resulting discussion will be central to developing an international consensus framework for transparent, replicable, ethical and effective research in artificial intelligence (AI-TREE) for health., Comment: 25 pages, 2 boxes, 1 figure

Published
2018

14. The Reviewer Academy of the Society of Critical Care Medicine: Key Principles and Strategic Plan

Author

Alexander, Peta M.A., Aslakson, Rebecca A., Barreto, Erin F., Lee, Jan Hau, Meissen, Heather, Morrow, Brenda M., Nazer, Lama, Branson, Richard D., Mayer, Kirby P., Napolitano, Natalie, Lane-Fall, Meghan B., Sikora, Andrea, John, Preeti R., Dellinger, R. Phillip, Parker, Margaret, Argent, Andrew, Boateng, Adjoa, Green, Thomas P., Kudchadkar, Sapna R., Maslove, David M., Rech, Megan A., Sorce, Lauren R., Tasker, Robert C., Buchman, Timothy G., and Checchia, Paul A.

Published
2023
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15. Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial

Author

Jones, Allison R, Patel, Rakesh P, Marques, Marisa B, Donnelly, John P, Griffin, Russell L, Pittet, Jean-Francois, Kerby, Jeffrey D, Stephens, Shannon W, DeSantis, Stacia M, Hess, John R, Wang, Henry E, Group, PROPPR Study, Holcomb, John B, Wade, Charles E, del Junco, Deborah J, Fox, Erin E, Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M, Tilley, Barbara C, Baraniuk, Sarah, Zhu, Hongjian, Nixon, Joshua, Seay, Roann, Appana, Savitri N, Yang, Hui, Gonzalez, Michael O, Baer, Lisa, Wang, Yao-Wei W, Hula, Brittany S, Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D, Sharma, Rishika, Cardenas, Jessica C, Rahbar, Elaheh, Burnett, Tyrone, Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P, Callum, Jeanne, Cotton, Bryan A, Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G, Gumbert, Sam D, Bai, Yu, McCarthy, James J, Noland, Amy, Hobbs, Rhonda, Bulger, Eileen M, Klotz, Patricia, Cattin, Lindsay, Warner, Keir J, Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A, Cohen, Mitchell J, Callcut, Rachael A, Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P, Maxim, Preston C, Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A, Robinson, Bryce RH, Branson, Richard D, Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M, Miller, Christopher N, Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G, Wong, Monica D, Menchine, Michael, Katzberg, Kelly, Henderson, Sean O, McKeever, Rodney, Shulman, Ira A, Nelson, Janice M, Tuma, Christopher W, and Matsushita, Cheryl Y

Subjects
Clinical Research, Clinical Trials and Supportive Activities, Hematology, Physical Injury - Accidents and Adverse Effects, Good Health and Well Being, Adult, Blood Preservation, Blood Transfusion, Critical Illness, Female, Hospital Mortality, Humans, Male, Middle Aged, Odds Ratio, Trauma Centers, PROPPR Study Group, Clinical Sciences, Emergency & Critical Care Medicine
Abstract

Study objectiveThe transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion.MethodsWe analyzed data from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial. Subjects in the parent trial included critically injured adult patients admitted to 1 of 12 North American Level I trauma centers who received at least 1 unit of packed RBCs and were predicted to require massive blood transfusion. The primary exposure was volume of packed RBC units transfused during the first 24 hours of hospitalization, stratified by packed RBC age category: 0 to 7 days, 8 to 14 days, 15 to 21 days, and greater than or equal to 22 days. The primary outcome was 24-hour mortality. We evaluated the association between transfused volume of each packed RBC age category and 24-hour survival, using random-effects logistic regression, adjusting for total packed RBC volume, patient age, sex, race, mechanism of injury, Injury Severity Score, Revised Trauma Score, clinical site, and trial treatment group.ResultsThe 678 patients included in the analysis received a total of 8,830 packed RBC units. One hundred patients (14.8%) died within the first 24 hours. On multivariable analysis, the number of packed RBCs greater than or equal to 22 days old was independently associated with increased 24-hour mortality (adjusted odds ratio [OR] 1.05 per packed RBC unit; 95% confidence interval [CI] 1.01 to 1.08): OR 0.97 for 0 to 7 days old (95% CI 0.88 to 1.08), OR 1.04 for 8 to 14 days old (95% CI 0.99 to 1.09), and OR 1.02 for 15 to 21 days old (95% CI 0.98 to 1.06). Results of sensitivity analyses were similar only among patients who received greater than or equal to 10 packed RBC units.ConclusionIncreasing quantities of older packed RBCs are associated with increased likelihood of 24-hour mortality in trauma patients receiving massive packed RBC transfusion (≥10 units), but not in those who receive fewer than 10 units.

Published
2019

16. Reporting Standards for Diagnostic Testing: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Author

Ost, David E., Feller-Kopman, David J., Gonzalez, Anne V., Grosu, Horiana B., Herth, Felix, Mazzone, Peter, Park, John E.S., Porcel, José M., Shojaee, Samira, Tsiligianni, Ioana, Vachani, Anil, Bernstein, Jonathan, Branson, Richard, Flume, Patrick A., Akdis, Cezmi A., Kolb, Martin, Portela, Esther Barreiro, and Smyth, Alan

Published
2023
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17. Mass Critical Care Surge Response During COVID-19: Implementation of Contingency Strategies – A Preliminary Report of Findings From the Task Force for Mass Critical Care

Author

Al-Awadhi, Anwar, Alptunaer, Timur, Baldisseri, Marie, Barfield, Wanda, Baum, Karyn D., Benditt, Joshua, Bowden, Kasey, Branson, Richard, Burry, Lisa D., Christian, Michael, Devereaux, Asha V., Dichter, Jeffrey R., Dominguez-Cherit, Guillermo, Downar, James, Dries, David, Einav, Sharon, Etienne, Mill, Evans, Laura, Feldman, Henry J., Geiling, James, Ghazipura, Marya, Gist, Ramon, Griffin, Kelly, Halpern, Neil, Hamele, Mitchell T., Henry, Kiersten, Hertelendy, Attila, Hick, John, Huffines, Meredith, Hupert, Nathaniel, Hossain, Tanzib, Ingbar, David, Kadri, Sameer S., Kesler, Sarah, King, Mary A., Kissoon, Niranjan, Koenig, Kristi, Lamana, Joseph, Leif, Lindsay, Levy, Deborah, Livinsky, Alicia, Martin, Christie, Martland, Anne Marie, Maves, Ryan C., Mitchell, Steven, Mukherjee, Vikramjit, Narasimhan, Mangala, Niven, Alexander, Ochoa, Juan, Ornoff, Doug, Parrish, J. Scott, Persoff, Jason, Powell, Tia, Reed, M.J., Rodriguez, Dario, Seda, Gilbert, Singh, Jaspal, Solar, Julie, Sprung, Charles L., Toner, Eric, Tosh, Pritish K., Uppal, Amit, Von-Maszewski, Marian, Ornoff, Douglas, Henry, Kiersten N., Bowden, Kasey R., Martland, Anne Marie O., Hick, John L., and Christian, Michael D.

Published
2022
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18. Risk Factors for the Development of Acute Respiratory Distress Syndrome Following Hemorrhage

Author

Robinson, Bryce RH, Cohen, Mitchell J, Holcomb, John B, Pritts, Timothy A, Gomaa, Dina, Fox, Erin E, Branson, Richard D, Callcut, Rachael A, Cotton, Bryan A, Schreiber, Martin A, Brasel, Karen J, Pittet, Jean-Francois, Inaba, Kenji, Kerby, Jeffery D, Scalea, Thomas M, Wade, Charlie E, and Bulger, Eileen M

Subjects
Rare Diseases, Prevention, Clinical Research, Patient Safety, Acute Respiratory Distress Syndrome, Hematology, Physical Injury - Accidents and Adverse Effects, Clinical Trials and Supportive Activities, Lung, Respiratory, Good Health and Well Being, Adult, Blood Component Transfusion, Crystalloid Solutions, Disease-Free Survival, Female, Hemorrhage, Humans, Length of Stay, Male, Middle Aged, Respiratory Distress Syndrome, Survival Rate, Damage control resuscitation, lung injury, massive hemorrhage, resuscitation, trauma, PROPPR Study Group, Clinical Sciences, Emergency & Critical Care Medicine
Abstract

BackgroundThe Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) study evaluated the effects of plasma and platelets on hemostasis and mortality after hemorrhage. The pulmonary consequences of resuscitation strategies that mimic whole blood, remain unknown.MethodsA secondary analysis of the PROPPR study was performed. Injured patients predicted to receive a massive transfusion were randomized to 1:1:1 versus 1:1:2 plasma-platelet-red blood cell ratios at 12 Level I North American trauma centers. Patients with survival >24 h, an intensive care unit (ICU) stay, and a recorded PaO2/FiO2 (P/F) ratio were included. Acute respiratory distress syndrome (ARDS) was defined as a P/F ratio

Published
2018

20. Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism

Author

McCully, Belinda H, Connelly, Christopher R, Fair, Kelly A, Holcomb, John B, Fox, Erin E, Wade, Charles E, Bulger, Eileen M, Schreiber, Martin A, Group, PROPPR Study, del Junco, Deborah J, Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M, Tilley, Barbara C, Baraniuk, Sarah, Nixon, Joshua, Seay, Roann, Appana, Savitri N, Yang, Hui, Gonzalez, Michael O, Baer, Lisa, Wang, Yao-Wei Willa, Hula, Brittany S, Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D, Sharma, Rishika, Cardenas, Jessica C, Rahbar, Elaheh, Burnett, Tyrone, Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P, Hess, John R, Callum, Jeanne, Cotton, Bryan A, Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G, Gumbert, Sam D, Bai, Yu, McCarthy, James J, Noland, Amy, Hobbs, Rhonda, Klotz, Patricia, Cattin, Lindsay, Warner, Keir J, Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A, Cohen, Mitchell Jay, Callcut, Rachael A, Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P, Maxim, Preston C, Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A, Robinson, Bryce RH, Branson, Richard D, Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M, Miller, Christopher N, Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G, Wong, Monica D, Menchine, Michael, Katzberg, Kelly, Henderson, Sean O, McKeever, Rodney, Shulman, Ira A, Nelson, Janice M, Tuma, Christopher W, Matsushita, Cheryl Y, Scalea, Thomas M, Stein, Deborah M, Shaffer, Cynthia K, and Wade, Christine

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Physical Injury - Accidents and Adverse Effects, Hematology, Clinical Research, Cardiovascular, Adult, Anticoagulants, Blood Coagulation Disorders, Blood Coagulation Tests, Female, Humans, Injury Severity Score, Male, Middle Aged, Recovery of Function, Thrombelastography, Trauma Centers, Venous Thromboembolism, Wounds and Injuries, PROPPR Study Group, Surgery, Clinical sciences
Abstract

BackgroundAltered coagulation function after trauma can contribute to development of venous thromboembolism (VTE). Severe trauma impairs coagulation function, but the trajectory for recovery is not known. We hypothesized that enhanced, early recovery of coagulation function increases VTE risk in severely injured trauma patients.Study designSecondary analysis was performed on data from the Pragmatic Randomized Optimal Platelet and Plasma Ratio (PROPPR) trial, excluding patients who died within 24 hours or were on pre-injury anticoagulants. Patient characteristics, adverse outcomes, and parameters of platelet function and coagulation (thromboelastography) were compared from admission to 72 hours between VTE (n = 83) and non-VTE (n = 475) patients. A p value < 0.05 indicates significance.ResultsDespite similar patient demographics, VTE patients exhibited hypercoagulable thromboelastography parameters and enhanced platelet function at admission (p < 0.05). Both groups exhibited hypocoagulable thromboelastography parameters, platelet dysfunction, and suppressed clot lysis (low clot lysis at 30 minutes) 2 hours after admission (p < 0.05). The VTE patients exhibited delayed coagulation recovery (a significant change compared with 2 hours) of K-value (48 vs 24 hours), α-angle (no recovery), maximum amplitude (24 vs 12 hours), and clot lysis at 30 minutes (48 vs 12 hours). Platelet function recovery mediated by arachidonic acid (72 vs 4 hours), ADP (72 vs 12 hours), and collagen (48 vs 12 hours) was delayed in VTE patients. The VTE patients had lower mortality (4% vs 13%; p < 0.05), but fewer hospital-free days (0 days [interquartile range 0 to 8 days] vs 10 days [interquartile range 0 to 20 days]; p < 0.05) and higher complication rates (p < 0.05).ConclusionsRecovery from platelet dysfunction and coagulopathy after severe trauma were delayed in VTE patients. Suppressed clot lysis and compensatory mechanisms associated with altered coagulation that can potentiate VTE formation require additional investigation.

Published
2017

26. Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial

Author

Holcomb, John B., Wade, Charles E, del Junco, Deborah J., Fox, Erin E., Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M., Tilley, Barbara C., Baraniuk, Sarah, Zhu, Hongjian, Nixon, Joshua, Seay, Roann, Appana, Savitri N., Yang, Hui, Gonzalez, Michael O., Baer, Lisa, Willa Wang, Yao-Wei, Hula, Brittany S., Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D., Sharma, Rishika, Cardenas, Jessica C., Rahbar, Elaheh, Burnett, Tyrone, Jr., Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P., Hess, John R., Callum, Jeanne, Cotton, Bryan A., Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G., Gumbert, Sam D., Bai, Yu, McCarthy, James J., Noland, Amy, Hobbs, Rhonda, Bulger, Eileen M., Klotz, Patricia, Cattin, Lindsay, Warner, Keir J., Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A., Cohen, Mitchell Jay, Callcut, Rachael A., Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P., Maxim, Preston C, Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A., Robinson, Bryce RH., Branson, Richard D., Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M., Miller, Christopher N., Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G., Wong, Monica D., Menchine, Michael, Katzberg, Kelly, Henderson, Sean O., McKeever, Rodney, Shulman, Ira A., Nelson, Janice M., Tuma, Christopher W., Matsushita, Cheryl Y, Scalea, Thomas M., Stein, Deborah M., Shaffer, Cynthia K., Wade, Christine, Herrera, Anthony V., Kallam, Seeta, Wade, Sarah E., Galvagno, Samuel M., Jr., Fontaine, Magali J., Hunt, Janice M., Cooke, Rhonda K., Fabian, Timothy C., Weinberg, Jordan A., Croce, Martin A., Wilson, Suzanne, Panzer-Baggett, Stephanie, Waddle-Smith, Lynda, Flax, Sherri, Brasel, Karen J., Walsh, Pamela, Milia, David, Nelson, Allia, Kaslow, Olga, Aufderheide, Tom P., Gottschall, Jerome L., Carpenter, Erica, O'Keeffe, Terence, Rokowski, Laurel L., Denninghoff, Kurt R., Redford, Daniel T., Novak, Deborah J., Knoll, Susan, Kerby, Jeffrey D., Pittet, Jean-Francois, Bosarge, Patrick L., Pierce, Albert T., Williams, Carolyn R., Stephens, Shannon W., Wang, Henry E., Marques, Marisa B., Schreiber, Martin A., Watters, Jennifer M., Underwood, Samantha J., Groat, Tahnee, Newgard, Craig, Merkel, Matthias, Scanlan, Richard M., Miller, Beth, Rizoli, Sandro, Tien, Homer, Nascimento, Barto, Trpcic, Sandy, Sobrian-Couroux, Skeeta, Reis, Marciano, Pérez, Adic, Belo, Susan E., Merkley, Lisa, Colavecchia, Connie, Wei, Shuyan, Gonzalez Rodriguez, Erika, Chang, Ronald, Kao, Lillian S., and Wade, Charles E.

Published
2018
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27. Sustainability in Respiratory Therapy: Revisiting Reusables.

Author

Branson, Richard D. and Ring, Brian J.

Subjects
ARTIFICIAL respiration equipment, ENDOTRACHEAL suctioning, INTENSIVE care units, SUSTAINABILITY, WASTE recycling, OPERATIVE surgery, MECHANICAL ventilators, COST control, CRITICAL care medicine, CATHETERS, MEDICAL equipment reuse, CLIMATE change
Abstract

The authors comment on a study published within the issue which is a life-cycle analysis (LCA) of closed versus open suction systems and the environmental footprint of each. Cited are the how the comparison of sustainability makes the study unique, the significance of prioritizing circular economy, based on reuse materials in the prevention of illnesses, and the strengths and limitations of the study.

Published
2024
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32. Abnormalities of laboratory coagulation tests versus clinically evident coagulopathic bleeding: results from the prehospital resuscitation on helicopters study (PROHS)

Author

Holcomb, John B., Wade, Charles E., Fox, Erin E., Chang, Ronald, Podbielski, Jeanette M., Tomasek, Jeffrey S., del Junco, Deborah J., Swartz, Michael D., DeSantis, Stacia M., Appana, Savitri N., Greene, Thomas J., Yi, Misung, Gonzalez, Michael O., Baraniuk, Sarah, van Belle, Gerald, Leroux, Brian G., Howard, Carrie L., Haymaker, Amanda, Stein, Deborah M., Scalea, Thomas M., Ayd, Benjamin, Das, Pratik, Herrera, Anthony V., Bulger, Eileen M., Robinson, Bryce R.H., Klotz, Patricia, Minhas, Aniqa, Kerby, Jeffrey D., Melton, Sherry M., Williams, Carolyn R., Stephens, Shannon W., Goodman, Michael, Johannigman, Jay A., McMullan, Jason, Branson, Richard D., Gomaa, Dina, Barczak, Christopher, Schreiber, Martin A., Underwood, Samantha J., Watson, Cheri, Zielinski, Martin D., Stubbs, James R., Headlee, Amy, O'Keeffe, Terence, Rhee, Peter, Rokowski, Laurel L., Santoro, John, Jr, Seach, Andrea, Bradford, David, Fealk, Michelle, Latifi, Fortesa, Inaba, Kenji, Kim, Henry, Chudnofsky, Carl, Wong, Monica D., Goodman, Michael D., Appana, Savitri, Johansson, Pär I., Henriksen, Hanne H., Stensballe, Jakob, and Steinmetz, Jacob

Published
2018
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34. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Author

Leisman, Daniel E., Harhay, Michael O., Lederer, David J., Abramson, Michael, Adjei, Alex A., Bakker, Jan, Ballas, Zuhair K., Barreiro, Esther, Bell, Scott C., Bellomo, Rinaldo, Bernstein, Jonathan A., Branson, Richard D., Brusasco, Vito, Chalmers, James D., Chokroverty, Sudhansu, Citerio, Giuseppe, Collop, Nancy A., Cooke, Colin R., Crapo, James D., Donaldson, Gavin, Fitzgerald, Dominic A., Grainger, Emma, Hale, Lauren, Herth, Felix J., Kochanek, Patrick M., Marks, Guy, Moorman, J. Randall, Ost, David E., Schatz, Michael, Sheikh, Aziz, Smyth, Alan R., Stewart, Iain, Stewart, Paul W., Swenson, Erik R., Szymusiak, Ronald, Teboul, Jean-Louis, Vincent, Jean-Louis, Wedzicha, Jadwiga A., and Maslove, David M.

Published
2020
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35. U.S. Food and Drug Administration Strategy to Evaluate Pulse Oximeters: The Same Cause Will Produce the Same Effects.

Author

Lellouche, François and Branson, Richard

Subjects
PULSE oximeters, CRITICALLY ill
Abstract

The article presents the discussion on limitations of the current protocol recommended by the U.S. Food and Drug Administration. Topics include evaluating pulse oximeters, emphasizing the need to address the impact of skin pigmentation and bias in hospitalized patients; and studies conducted among healthy subjects and those among patients, urging for a reevaluation of evaluation strategies to ensure accuracy, especially for individuals with darker skin tones.

Published
2024
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37. Onset of Coagulation Function Recovery Is Delayed in Severely Injured Trauma Patients with Venous Thromboembolism

Author

Holcomb, John B., Wade, Charles E., del Junco, Deborah J., Fox, Erin E., Matijevic, Nena, Podbielski, Jeanette, Beeler, Angela M., Tilley, Barbara C., Baraniuk, Sarah, Nixon, Joshua, Seay, Roann, Appana, Savitri N., Yang, Hui, Gonzalez, Michael O., Baer, Lisa, Willa Wang, Yao-Wei, Hula, Brittany S., Espino, Elena, Nguyen, An, Pawelczyk, Nicholas, Arora-Nutall, Kisha D., Sharma, Rishika, Cardenas, Jessica C., Rahbar, Elaheh, Burnett, Tyrone, Jr., Clark, David, van Belle, Gerald, May, Susanne, Leroux, Brian, Hoyt, David, Powell, Judy, Sheehan, Kellie, Hubbard, Alan, Arkin, Adam P., Hess, John R., Callum, Jeanne, Cotton, Bryan A., Vincent, Laura, Welch, Timothy, Poole, Tiffany, Pivalizza, Evan G., Gumbert, Sam D., Bai, Yu, McCarthy, James J., Noland, Amy, Hobbs, Rhonda, Bulger, Eileen M., Klotz, Patricia, Cattin, Lindsay, Warner, Keir J., Wilson, Angela, Boman, David, White, Nathan, Grabinsky, Andreas, Daniel-Johnson, Jennifer A., Cohen, Mitchell Jay, Callcut, Rachael A., Nelson, Mary, Redick, Brittney, Conroy, Amanda, Steurer, Marc P., Maxim, Preston C., Fiebig, Eberhard, Moore, Joanne, Mallari, Eireen, Muskat, Peter, Johannigman, Jay A., Robinson, Bryce RH., Branson, Richard D., Gomaa, Dina, Barczak, Christopher, Bennett, Suzanne, Carey, Patricia M., Miller, Christopher N., Hancock, Helen, Rodriguez, Carolina, Inaba, Kenji, Zhu, Jay G., Wong, Monica D., Menchine, Michael, Katzberg, Kelly, Henderson, Sean O., McKeever, Rodney, Shulman, Ira A., Nelson, Janice M., Tuma, Christopher W., Matsushita, Cheryl Y., Scalea, Thomas M., Stein, Deborah M., Shaffer, Cynthia K., Wade, Christine, Herrera, Anthony V., Kallam, Seeta, Wade, Sarah E., Galvagno, Samuel M., Jr., Fontaine, Magali J., Hunt, Janice M., Cooke, Rhonda K., Fabian, Timothy C., Weinberg, Jordan A., Croce, Martin A., Wilson, Suzanne, Panzer-Baggett, Stephanie, Waddle-Smith, Lynda, Flax, Sherri, Brasel, Karen J., Walsh, Pamela, Milia, David, Nelson, Allia, Kaslow, Olga, Aufderheide, Tom P., Gottschall, Jerome L., Carpenter, Erica, O'Keeffe, Terence, Rokowski, Laurel L., Denninghoff, Kurt R., Redford, Daniel T., Novak, Deborah J., Knoll, Susan, Kerby, Jeffrey D., Pittet, Jean-Francois, Bosarge, Patrick L., Pierce, Albert T., Williams, Carolyn R., Stephens, Shannon W., Wang, Henry E., Marques, Marisa B., Schreiber, Martin A., Watters, Jennifer M., Underwood, Samantha J., Groat, Tahnee, Newgard, Craig, Merkel, Matthias, Scanlan, Richard M., Miller, Beth, Rizoli, Sandro, Tien, Homer, Nascimento, Barto, Trpcic, Sandy, Sobrian-Couroux, Skeeta, Reis, Marciano, Pérez, Adic, Belo, Susan E., Merkley, Lisa, Colavecchia, Connie, McCully, Belinda H., Connelly, Christopher R., and Fair, Kelly A.

Published
2017
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38. Impact of ... Targets and Pulse Oximeter Brand on Oxygen Flow Requirements and Oxygenation.

Author

Lellouche, François, Bouchard, Pierre-Alexandre, and Branson, Richard D.

Subjects
OXYGEN consumption, OXYGEN saturation, RANDOMIZED controlled trials, DESCRIPTIVE statistics, PULSE oximeters, REACTIVE oxygen species, STATISTICAL sampling, OXYGEN in the body
Abstract

The article presents the results of a prospective randomized crossover study on the effects of SpO2 targets and pulse oximeter brand on oxygen flow requirements and oxygenation to avoid hypoxemia and hyperoxemia. Other topics include the impact of skin pigmentation on oximeter accuracy and how said targets and brand affect the decision to escalate or de-escalate respiratory support.

Published
2024
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40. Beware the siren's song of novel endotracheal tube designs

Author

Klompas, Michael, Berra, Lorenzo, and Branson, Richard

Subjects
Bacterial pneumonia, Medical colleges, Pneumonia, Health care industry
Abstract

Author(s): Michael Klompas [sup.1] [sup.2], Lorenzo Berra [sup.3], Richard Branson [sup.4] Author Affiliations: (1) 000000041936754X, grid.38142.3c, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, , [...]

Published
2017
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42. Meeting the challenge of COPD care delivery in the USA: a multiprovider perspective

Author

Han, MeiLan K, Martinez, Carlos H, Au, David H, Bourbeau, Jean, Boyd, Cynthia M, Branson, Richard, Criner, Gerard J, Kalhan, Ravi, Kallstrom, Thomas J, King, Angela, Krishnan, Jerry A, Lareau, Suzanne C, Lee, Todd A, Lindell, Kathleen, Mannino, David M, Martinez, Fernando J, Meldrum, Catherine, Press, Valerie G, Thomashow, Byron, Tycon, Laura, Sullivan, Jamie Lamson, Walsh, John, Wilson, Kevin C, Wright, Jean, Yawn, Barbara, Zueger, Patrick M, Bhatt, Surya P, and Dransfield, Mark T

Published
2016
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