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32 results on '"Brankley, Shannon"'

1. An Optimized Set of Fluorescence In Situ Hybridization Probes for Detection of Pancreatobiliary Tract Cancer in Cytology Brush Samples

Author

Barr Fritcher, Emily G., Voss, Jesse S., Brankley, Shannon M., Campion, Michael B., Jenkins, Sarah M., Keeney, Matthew E., Henry, Michael R., Kerr, Sarah M., Chaiteerakij, Roongruedee, Pestova, Ekaterina V., Clayton, Amy C., Zhang, Jun, Roberts, Lewis R., Gores, Gregory J., Halling, Kevin C., and Kipp, Benjamin R.

Published
2015
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9. Mo1368 A Targeted Multicolor FISH Probe Set Increases the Diagnostic Sensitivity for Detecting Malignancy in Pancreatobiliary Brushings

Author

Barr Fritcher, Emily G., primary, Voss, Jesse S., additional, Brankley, Shannon, additional, Campion, Michael B., additional, Jenkins, Sarah M., additional, Smith, Carin Y., additional, Kerr, Sarah E., additional, Pestova, Ekaterina V., additional, Sokolova, Irina A., additional, Song, Minghao, additional, Chaiteerakij, Roongruedee, additional, Roberts, Lewis R., additional, Gores, Gregory J., additional, Halling, Kevin C., additional, and Kipp, Benjamin R., additional

Published
2015
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11. Fluorescence In-situ Hybridization (FISH) for Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements on Previously Stained Routine Cytology Specimens

Author

Brankley, Shannon, primary, Henry, Michael, additional, Halling, Kevin, additional, Yi, Eunhee, additional, Minot, Douglas, additional, Voss, Jesse, additional, Pestova, Ekaterina, additional, Song, Minghao, additional, Kerr, Sarah, additional, Fritcher, Emily Barr, additional, and Kipp, Benjamin, additional

Published
2014
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14. 1001 Clonal Diversity of Barrett's Esophagus With High Grade Dysplasia Decreases After Endoscopic Mucosal Resection

Author

Westra, Wytske, primary, de Wit, Gerard M., additional, Iyer, Prasad G., additional, Brankley, Shannon, additional, Halling, Kevin C., additional, Buttar, Navtej, additional, Wong Kee Song, Louis M., additional, Lutzke, Lori S., additional, Dunagan, Kelly T., additional, Goddard, Teresa, additional, Wang, Kenneth K., additional, and Krishnadath, Kausilia K., additional

Published
2013
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16. Mo1923 Non-Dysplastic Barrett's Esophagus Is Not Created the Same: Genetic Abnormalities in Non-Dysplastic Barrett's Esophagus Are Dependent on Clinical Context

Author

Timmer, Margriet R., primary, Brankley, Shannon, additional, Gorospe, Emmanuel C., additional, Iyer, Prasad G., additional, Lutzke, Lori S., additional, Anderson, Marlys, additional, Krishnadath, Kausilia K., additional, Halling, Kevin C., additional, and Wang, Kenneth K., additional

Published
2013
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20. S1629 Low and High-Level Chromosomal Gains of 8q24 (c-MYC), 17q12 (HER2), and 20q13 Detected by Fluorescence in Situ Hybridization (FISH) in Cytologic Brushing Specimens From Patients With Barrett's Esophagus

Author

Brankley, Shannon M., primary, Fritcher, Emily Barr, additional, Campion, Michael B., additional, Lutzke, Lori S., additional, Oberg, Trynda N., additional, Voss, Jesse S., additional, Wang, Kenneth K., additional, Westra, Wytske, additional, Tomizawa, Yutaka, additional, and Halling, Kevin C., additional

Published
2010
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21. M1511: Advanced Imaging of Cellular Architectural and Molecular Alterations in Barrett's Esophagus

Author

Tomizawa, Yutaka, primary, Brankley, Shannon M., additional, Fritcher, Emily Barr, additional, Campion, Michael B., additional, Prasad, Ganapathy A., additional, Song, Louis-Michel Wong Kee, additional, Buttar, Navtej, additional, Anderson, Marlys, additional, Dunagan, Kelly T., additional, Borkenhagen, Lynn S., additional, Lutzke, Lori S., additional, Halling, Kevin C., additional, and Wang, Kenneth K., additional

Published
2010
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22. W1901 Biomarker Status At Initial Fluorescence in Situ Hybridization (FISH) On Brush Cytology Specimens Can Predict Long-Term Outcome in Barrett's Esophagus Patients with High-Grade Dysplasia

Author

Westra, Wytske, primary, Prasad, Ganapathy A., additional, Halling, Kevin C., additional, Brankley, Shannon M., additional, Fritcher, Emily Barr, additional, Oberg, Trynda N., additional, Voss, Jesse S., additional, Campion, Michael B., additional, Buttar, Navtej, additional, Song, Louis-Michel Wong Kee, additional, Lutzke, Lori S., additional, Dunagan, Kelly T., additional, Borkenhagen, Lynn S., additional, Rygiel, Agnieszka M., additional, Krishnadath, Kausilia K., additional, and Wang, Kenneth K., additional

Published
2009
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23. 1036 Prospective Randomized Controlled Trial of Biomarkers to Predict Response to Ablation Therapy in Barrett's Esophagus (BE) with High Grade Dysplasia (HGD)

Author

Wang, Kenneth K., primary, Brankley, Shannon M., additional, Prasad, Ganapathy A., additional, Song, Louis-Michel Wong Kee, additional, Buttar, Navtej, additional, Fritcher, Emily Barr, additional, Lutzke, Lori S., additional, Borkenhagen, Lynn S., additional, Halling, Kevin C., additional, and Anderson, Marlys, additional

Published
2009
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24. W1896 Prospective Randomized Multicenter Study of FISH in Patients with Barrett's Esophagus (BE)

Author

Wang, Kenneth K., primary, Buttar, Navtej, additional, Prasad, Ganapathy A., additional, Song, Louis-Michel Wong Kee, additional, Halling, Kevin C., additional, Brankley, Shannon M., additional, Fritcher, Emily Barr, additional, Falk, Gary W., additional, Tomizawa, Yutaka, additional, Vargo, John J., additional, Borkenhagen, Lynn S., additional, and Lutzke, Lori S., additional

Published
2009
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25. T1883 Detection of High-Grade Dysplasia and Esophageal Adenocarcinoma Using Endoscopic Mucosal Resection in Combination with Fluorescence in Situ Hybridization

Author

Westra, Wytske, primary, Prasad, Ganapathy A., additional, Halling, Kevin C., additional, Brankley, Shannon M., additional, Fritcher, Emily Barr, additional, Oberg, Trynda N., additional, Voss, Jesse S., additional, Campion, Michael B., additional, Buttar, Navtej, additional, Kee Song, Louis-Michel Wong, additional, Lutzke, Lori S., additional, Dunagan, Kelly T., additional, Borkenhagen, Lynn S., additional, Rygiel, Agnieszka M., additional, Krishnadath, Kausilia K., additional, and Wang, Kenneth K., additional

Published
2009
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30. Correlation of histology with biomarker status after photodynamic therapy in Barrett esophagus.

Author

Ganapathy A. Prasad, Wang, Kenneth K., Halling, Kevin C., Buttar, Navtej S., Wongkeesong, Louis-Michel, Zinsmeister, Alan R., Brankley, Shannon M., Westra, Wytske M., Lutzke, Lori S., Borkenhagen, Lynn S., Dunagan, Kelly, and Prasad, Ganapathy A

Subjects
ESOPHAGEAL cancer, BARRETT'S esophagus, BIOMARKERS, PHOTOCHEMOTHERAPY, CANCER treatment, CANCER chemotherapy, PORPHYRINS, ALGORITHMS, CANCER, COMPARATIVE studies, ESOPHAGEAL tumors, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, RESEARCH, RESEARCH funding, FLUORESCENCE in situ hybridization, DISEASE relapse, EVALUATION research, THERAPEUTICS
Abstract

Background: Currently, histology is used as the endpoint to define success with photodynamic therapy (PDT) in patients with high-grade dysplasia (HGD). Recurrences despite 'successful' ablation are common. The role of biomarkers in assessing response to PDT remains undefined. The objectives of the current study were 1) to assess biomarkers in a prospective cohort of patients with HGD/mucosal cancer before and after PDT and 2) to correlate biomarker status after PDT with histology.Methods: Patients who underwent PDT for HGD/mucosal cancer were studied prospectively. All patients underwent esophagogastroduodenoscopy, 4-quadrant biopsies every centimeter, endoscopic mucosal resection of visible nodules, and endoscopic ultrasound. Cytology samples were obtained by using standard cytology brushes. Biomarkers were assessed by using fluorescence in situ hybridization (FISH). The biomarkers that were assessed included loss of 9p21 (site of the p16 gene) and 17p13.1 (site of the p53 gene) loci; gains of the 8q24(c-myc), 17q (HER2-neu), and 20q13 loci; and multiple gains. Patients received PDT 48 hours after the administration of sodium porfimer. Demographic and clinical variables were collected prospectively. Patients were followed with endoscopy and repeat cytology for biomarkers. The McNemar test was used to compare biomarker proportions before and after PDT.Results: Thirty-one patients were studied. The median patient age was 66 years (interquartile range [IQR], 56-73 years), and 28 patients (88%) were men. The mean Barrett segment length was 5 cm (standard error of the mean, 0.5 cm). Post-PDT biomarkers were obtained after a median duration of 9 months (IQR, 3-12 months). There was a statistically significant decrease in the proportion of several biomarkers assessed after PDT. Six patients without HGD after PDT still had positive FISH results for 1 or more biomarkers: of these, 2 patients (33%) developed recurrent HGD.Conclusions: In this initial study, histologic downgrading of dysplasia after PDT was associated with the loss of biomarkers that have been associated with progression of neoplasia in Barrett esophagus. Patients with persistently positive biomarkers appeared to be at a higher risk of recurrent HGD. These findings should be confirmed in a larger study. [ABSTRACT FROM AUTHOR]

Published
2008
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31. The Development of a Fluorescence in SituHybridization Assay for the Detection of Dysplasia and Adenocarcinoma in Barrett's Esophagus

Author

Brankley, Shannon M., Wang, Kenneth K., Harwood, Aaron R., Miller, Dylan V., Legator, Mona S., Lutzke, Lori S., Kipp, Benjamin R., Morrison, Larry E., and Halling, Kevin C.

Abstract

The goal of this study was to identify a set of fluorescence in situhybridization probes for the detection of dysplasia and adenocarcinoma in patients with Barrett's esophagus. We examined 170 brushing specimens from 138 patients with Barrett's esophagus or a history of Barrett's esophagus using fluorescence in situ hybridization with probes to 5p15, 5q21-22, centromere 7, 7p12, 8q24.12-13, centromere 9, 9p21, centromere 17, 17p13.1, 17q11.2-12, 20q13.2, and centromere Y. Receiver-operator curves were used to determine the sensitivity and specificity of various four-probe combinations for detecting low-grade dysplasia, high-grade dysplasia, and esophageal adenocarcinoma. Endoscopic biopsy results were used as the gold standard. Numerous four-probe combinations provided a similarly high sensitivity and specificity. Of these, a set consisting of probes to 8q24, 9p21, 17q11.2, and 20q13.2 was found to have a sensitivity and specificity, respectively, of 70% and 89% for low-grade dysplasia, 84% and 93% for high-grade dysplasia, and 94% and 93% for esophageal adeno-carcinoma. This probe set was chosen for future prospective clinical evaluations based on its high sensitivity and specificity, its ability to distinguish adenocarcinoma and high-grade or low-grade dysplasia from lesser diagnostic categories, and the favorable signal quality for each of the probes.

Published
2006
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32. A study of the reproducibility of a fluorescence in situ hybridization bladder cancer detection assay.

Author

Brankley SM, Adams EJ, Christensen MR, Everts CR, Lund JD, Oberg TN, Plagge AM, Zieman AH, Kipp BR, and Halling KC

Subjects
Carcinoma, Transitional Cell genetics, Carcinoma, Transitional Cell urine, Chromosome Aberrations, DNA, Neoplasm analysis, Humans, Observer Variation, Reproducibility of Results, Urinary Bladder Neoplasms genetics, Urinary Bladder Neoplasms urine, Urothelium pathology, Carcinoma, Transitional Cell diagnosis, In Situ Hybridization, Fluorescence, Urinary Bladder Neoplasms diagnosis
Abstract

Objective: To assess the reproducibility of the UroVysion fluorescence in situ hybridization (FISH) bladder cancer detection assay., Study Design: Thirteen specimens (2 negative, 3 low-level positive [1-10% abnormal cells], 5 mid-level positive [11-75%], and 3 high-level positive [>75%]) were analyzed by 7 cytotechnologists. Each cytotechnologist rendered an overall diagnosis of positive or negative and determined the percentage of abnormal urothelial cells for all positive specimens., Results: The interobserver reproducibility of the assay was 100% for mid-level and high-level positive specimens, 93% for negative specimens, and 78% for low-level positive specimens. The range of percent abnormal determinations was highest for mid-level positive specimens, with mean SDs of 1.8%, 16.4% and 10.1% for the low-, mid-, and high-level positives, respectively., Conclusion: There was a high level of reproducibility among the mid- and high-level positive specimens. The reproducibility for low-level positive specimens was lowest, suggesting that such specimens should be reviewed by a second technologist to ensure an accurate diagnosis. The findings of this study are important for further elucidating the clinical value of quantitative FISH analysis in the management of patients undergoing FISH testing for bladder cancer.

Published
2008

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