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Alfredomaria Lurati,1 Antonella Laria,1 Arianna Gatti,2 Bruno Brando,2 Magda Scarpellini1 1Rheumatology Unit, Fornaroli Hospital, Magenta, Italy; 2Transfusional Centre, Legnano Hospital, Legnano, Italy Objective: To determine distribution of T cells and activation degree of Th CD4+ cells in peripheral blood of patients with osteoarthritis (OA), rheumatoid arthritis (RA), and healthy donors. Methods: Patients with established diagnosis of RA according to American College of Rheumatology/European League Against Rheumatism 2010 criteria, knee or hip OA according to American College of Rheumatology criteria, and healthy blood donor volunteers were eligible. Multi-channel flow cytometry and monoclonal antibodies against CD3, CD4, CD8, CCR6, CD38, CXCR3, and HLA DR were used to distinguish and evaluate T cells' subpopulation. Results: We analyzed blood samples of 15 patients with well-defined RA, 56 with hip or knee OA, and 20 healthy age matched controls. Blood samples from RA patients showed significantly higher counts of CD4+ CD38+ DR+ (activated CD4 T cells) and Th17 (CCR6+ CXCR3-) cells as compared to OA patients and control group (P0.1). Conclusion: According to the latest view of OA disease pathogenesis, our preliminary results support the hypothesis that OA may also be a disease with an immunological/inflammatory involvement like RA. It seems that there is a quantitative but non-qualitative difference in Th17 cells' profile, including the expression of activation markers, between RA and OA. Keywords: Th17, flow cytometry, osteoarthritis

Abstract We study the eikonal scattering of two gravitationally interacting bodies, in the regime of large angular momentum and large center of mass energy. We show that eikonal exponentiation of the scattering phase matrix is a direct consequence of the group contraction SU(2) → ISO(2), from rotations to the isometries of the plane, in the large angular momentum limit. We extend it to all orders in the scattering angle, and for all masses and spins. The emergence of the classical limit is understood in terms of the continuous-spin representations admitted by ISO(2). We further investigate the competing classical vs quantum corrections to the leading classical eikonal scattering, and find several interesting examples where quantum corrections are more important than Post-Minkowskian’s. As a case of study, we analyse the scattering of a photon off a massless neutral scalar field, up to next-to-leading order in the Newton constant, and to leading order in the fine structure constant. We investigate the causal structure of the eikonal regime and establish an infinite set of non-linear positivity bounds, of which positivity of time delay is the simplest.

Abstract We study causality in gravitational systems beyond the classical limit. Using on-shell methods, we consider the 1-loop corrections from charged particles to the photon energy-momentum tensor — the self-stress — that controls the quantum interaction between two on-shell photons and one off-shell graviton. The self-stress determines in turn the phase shift and time delay in the scattering of photons against a spectator particle of any spin in the eikonal regime. We show that the sign of the β-function associated to the running gauge coupling is related to the sign of time delay at small impact parameter. Our results show that, at first post-Minkowskian order, asymptotic causality, where the time delay experienced by any particle must be positive, is respected quantum mechanically. Contrasted with asymptotic causality, we explore a local notion of causality, where the time delay is longer than the one of gravitons, which is seemingly violated by quantum effects.

The primary objective of this study was to analyze the psychometric properties of the Inventory for the Identification and Analysis of Psychosocial Risk Factors (IIA-PRF) of Reference Guide III proposed in NOM-035-STPS-2018. A total of 2,149 workers in Baja California, Mexico’s industrial and education-government sectors, were administered an online inventory version. Preliminary analyses were performed, as well as a Confirmatory Factor Analysis (CFA) based on two models proposed by the standard itself: an eight-factor model (8-FM) and a four-factor model (4-FM). Likewise, based on the results and with the recommendations of the specialists, a threefactor model (3-FM) was proposed. In addition, nested model sequencing methods were subsequently applied to validate the invariance between the origin of the activity. The dimensionality of 3-FM was found to have adequate fit values according to a-priori established criteria. It is concluded that the IIAPRF does not have the reliability and validity parameters necessary to support interpretations, uses and consequences based on the theoretical structure established by NOM-035-STPS-2018 and that, although the 3-FM presents better reliability and validity indices, it is not invariant in terms of the origin of the activity. Finally, we discuss the implications and recommend reviewing and adjusting the design of the IIAPRF items to extend the measurement of invariance to other groups of relevance for decision making in the improvement of the work environment.

El propósito del presente estudio es medir la actitud hacia la cooperación tecno-científica entre Instituciones de Educación Superior y Empresas del Sector Productivo de profesores-investigadores, así como analizar las diferencias por sexo, edad, y nivel en el Sistema Nacional de Investigadores. Se utilizó una muestra no aleatoria por conveniencia de 182 p-i (50 mujeres y 132 hombres) quienes contestaron el Cuestionario para medir la percepción de la cooperación tecno-científica entre las Instituciones de Educación Superior y el Sector Productivo. Entre los hallazgos, se destacan valores de diferencia no significativa (p > .05), y tamaño de efecto chico (η2 = .01) entre los grupos.

The use of scales to assess the performance of professors from the students' standpoint is a generalized practice in higher education systems worldwide. The purpose of this study is to analyze the factorial structure and measure the invariance of the Scale of Teaching Performance of the Psychology Professor (EDDPsic) among groups according to gender, age, and academic stage. The sample of participants was composed of 316 Psychology students from the fourth and sixth semesters (basic cycles), and from the eighth and tenth semesters (disciplinary-professional cycles) of two renowned public universities in Lima, Peru. Two hundred and thirty-one participants were women (73%), and the mean age of students was 21.5 years old (SD = 2.37). The measurement invariance of the scale in the three study variables was underpinned by a multigroup confirmatory factor analysis (MGCFA) conducted using a five-factor model that showed the best fitness indices. It is concluded that significant differences in measuring teaching performance areas of the professor depend on the students' age difference and on their academic stage (to attend the disciplinary-professional cycles).

Abstract We construct the effective field theory for a single massive higher-spin particle in flat spacetime. Positivity bounds of the S-matrix force the cutoff of the theory to be well below the naive strong-coupling scale, forbid any potential and make therefore higher- derivative operators important even at low energy. As interesting application, we discuss in detail the massive spin-3 theory and show that an extended Galileon-like symmetry of the longitudinal modes, even with spin, emerges at high energy.