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Abstract This study evaluates the impact of hydroclimate-driven periodic runoff on hydropower operations and production, with a focus on how the forecasted biennial periodicity of runoff time series could affect the efficiency of hydropower generation. Hydrologic stochastic processes are utilized to forecast long-term runoff, and seven hydroclimate scenarios are developed to be input into a production management model, allowing for an analysis of how periodic hydroclimate variations influence hydropower management and output. The results reveal that the biennial alternation between wet and dry years is a key factor affecting hydropower operations in the Dalälven River Basin. Notable differences between wet- and dry-year scenarios were observed in terms of power efficiency, production output, and forecasting accuracy. Operating hydropower systems based on dry-year runoff forecasts in wet years results in a 1.63% decrease in production efficiency and a reduction of 9,104 MWh in power generation. Conversely, applying wet-year forecasts in dry years slightly boosts production efficiency by 0.31% and increases power generation by 7,832 MWh. Scenarios that adhere to biennial periodicity offer the highest forecasting accuracy, particularly when applying dry-year forecasts in dry years in winter and spring, which produce the most precise predictions. In contrast, using dry-year forecasts in wet years results in the lowest forecasting accuracy.

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search for non-biological antivirals, special emphasis was placed on drug repurposing to accelerate the clinical implementation of effective drugs. The life cycle of the virus has been extensively investigated and many human targets have been identified, such as the molecular chaperone GRP78, representing a host auxiliary factor for SARS-CoV-2 entry. Here we report the inhibitor capacity of TL1228, a small molecule discovered through an in silico screening approach, which could interfere with the interaction of SARS-CoV-2 and its target cells, blocking the recognition of the GRP78 cellular receptor by the viral Spike protein. TL1228 showed in vitro the ability to reduce significantly both pseudoviral and authentic viral activity even through the reduction of GRP78/ACE2 transcript levels. Importantly, TL1228 acts in modulating expression levels of innate immunity and as inflammation markers.

Our multifaceted society calls for engineers that are not only experts in their domain, but possess the flexibility to understand adjacent disciplines. The inclusion of the performing arts in engineering curricula has shown potential for cultivating creativity and equipping STEM students with problem-solving abilities. However, the literature offers limited examples of such integration in engineering courses. We present a unique learning experience involving engineering students from the Royal Institute of Technology (KTH) and circus students from Bachelor's programme in Circus at Stockholm School of the Arts (SKH). Grounded in the concepts of "docendo discimus, presentational dimension" of circus and "reflective thinking," our study aimed to: (1) explore engineering students' acceptance of an unconventional collaboration with circus peers; and (2) assess the pedagogical value of this collaboration for the engineering students. We highlight challenges and potentialities of this collaboration, to inform educators interested in creative teaching approaches.

The increasing societal concern for consumer information privacy has led to the enforcement of privacy regulations worldwide. In an effort to adhere to privacy regulations such as the General Data Protection Regulation (GDPR), many companies’ privacy policies have become increasingly lengthy and complex. In this study, we adopted the computational design science paradigm to design a novel privacy policy evolution analytics framework to help identify how companies change and present their privacy policies based on privacy regulations. The framework includes a self-attentive annotation system (SAAS) that automatically annotates paragraph-length segments in privacy policies to help stakeholders identify data practices of interest for further investigation. We rigorously evaluated SAAS against state-of-the-art machine learning (ML) and deep learning (DL)-based methods on a well-established privacy policy dataset, OPP-115. SAAS outperformed conventional ML and DL models in terms of F1-score by statistically significant margins. We demonstrate the proposed framework’s practical utility with an in-depth case study of GDPR’s impact on Amazon’s privacy policies. The case study results indicate that Amazon’s post-GDPR privacy policy potentially violates a fundamental principle of GDPR by causing consumers to exert more effort to find information about first-party data collection. Given the increasing importance of consumer information privacy, the proposed framework has important implications for regulators and companies. We discuss several design principles followed by the SAAS that can help guide future design science-based e-commerce, health, and privacy research. [ABSTRACT FROM AUTHOR]

Developing and implementing climate adaptation measures in complex socio-ecological systems can lead to unintended consequences, especially when those systems are undergoing rapid hydro-climatic and socio-economic change. In these dynamic contexts, a systemic approach can make the difference between adaptive and maladaptive outcomes. This paper focuses on the use of climate services, often touted as no-regret solutions, and their potential to generate maladaptation. We explored the interactions between climate services and adaptation/maladaptation across five case studies affected by different types of natural hazards and characterized by a range of hydro-climatic and socio-economic conditions. Using system archetypes, we show how climate services can play a role in both producing and preventing maladaptation. The dynamics explored through system archetypes are: i) “fixes that fail”, where short-sighted solutions fail to address the root causes of a problem; ii) “band aid solutions”, where the benefits brought about in the short-term come at the expenses of delaying long-term adaptive actions; and iii) “success to the successful”, where some groups increasingly benefit from climate services at the expenses of other groups. We demonstrate how these dynamics constitute maladaptive processes, as well as identifying the tools and theories that can be used in this type of assessment. Finally, we provide a framework and recommendations to guide the ex-ante assessment of maladaptation risk when designing and implementing climate services.

Mild-to-moderate ulcerative colitis (UC) management is centred on 5-aminosalicylic acid (5-ASA) derivatives. Whether supplementing 5-ASA with nutraceuticals can provide real advantages in UC-relevant outcomes is unclear. This retrospective multicentre study compared clinical remission, response rates, and faecal calprotectin levels in a two-arm design, including patients treated with 5-ASA alone and those with additional H. erinaceus-based multi-compound supplementation. In the 5-ASA alone group, clinical response rates were 41% at three months (T1) and 60.2% at six months (T2), while corresponding clinical remission rates were 16.9% and 36.1%. In the nutraceutical supplementation group, clinical response rates were 49.6% (T1) and 70.4% (T2), with clinical remission rates of 30.4% (T1) and 50.9% (T2). No significant differences in clinical response rates between the groups at T1 (p = 0.231) and T2 (p = 0.143) emerged. Clinical remission rates differed significantly at both time points (p = 0.029 and p = 0.042, respectively). Faecal calprotectin levels decreased significantly in both groups during the retrospective follow-up (p < 0.05), and this was more pronounced in nutraceutical supplementation patients at both T1 (p = 0.005) and T2 (p = 0.01). No adverse events were reported. This multi-component nutraceutical supplementation offers real-world potential in controlling disease activity in patients with mild-to-moderate UC.

Background: Gastroesophageal reflux disease (GERD) is a challenging condition that involves different physicians, such as general practitioners (GPs), gastroenterologists, and ears, nose and throat (ENT) specialists. A common approach consists of proton-pump inhibitors (PPIs) administration. Adjunctive pharmacological treatment may have a role in the management of non-responders to PPIs. Objectives: We aimed to survey GPs and different medical specialists to investigate the medical approaches to patients reporting GERD symptoms. In addition, we examined the use of adjunctive pharmacological treatments in patients with GERD symptoms who do not respond to PPIs. Design: Retrospective observational study. Methods: A survey was conducted among a large sample of gastroenterologists, GPs, and ENT specialists. Symptoms were divided into typical and extraesophageal, and their severity and impact on quality of life were explored with the GERD Impact Scale and with Reflux Symptom Index (RSI). All therapies administered usually for GERD were investigated. Results: A total of 6211 patients were analyzed in this survey. Patients with typical symptoms were 53.5%, while those with extraesophageal symptoms were 46.5%. The latter were more frequently reported by ENT patients (53.6%, p

Mediterranean water-stressed areas face significant challenges from higher temperatures and increasingly severe droughts. We assess the effect of climate change on rainfed barley production in the aridity-prone province of Almería, Spain, using the FAO AquaCrop model. We focus on rainfed barley growth by the mid-century (2041–2070) and end-century (2071–2100) time periods, using three Shared Socio-economic Pathway (SSP)-based scenarios: SSP1-2.6, SSP2-4.5, and SSP5-8.5. Using the paired t-test, Spearman and Pearson correlation coefficient, Root Mean Squared Error, and relative Root Mean Squared Error, we verified AquaCrop’s ability to capture local multi-year trends (9 or more years) using standard barley crop parameters, without local recalibration. Starting with a reference Initial Soil Water Content (ISWC), different soil water contents within barley rooting depth were modelled to account for decreases in soil water availability. We then evaluated the efficiency of different climate adaptation strategies: irrigation, mulching, and changing sowing dates. We show average yield changes of +14% to −44.8% (mid-century) and +12% to −55.1% (end-century), with ISWC being the main factor determining yields. Irrigation increases yields by 21.1%, utilizing just 3% of Almería’s superficial water resources. Mulches improve irrigated yield performances by 6.9% while reducing irrigation needs by 40%. Changing sowing dates does not consistently improve yields. We demonstrate that regardless of the scenario used, climate adaptation of field barley production in Almería should prioritize limiting soil water loss by combining irrigation with mulching. This would enable farmers in Almería’s northern communities to maintain their livelihoods, reducing the province’s reliance on horticulture while continuing to contribute to food security goals.

This study compares physical and chemical parameters of water samples collected in a marginal lake (Castelo Bay) in the Paraguay River Basin in southern Pantanal during a significant natural phenomenon of hypoxia, locally called decoada, and shortly after it. Limnological parameters were analyzed from four sampling sites along the bay. Comparisons of the physical and chemical parameters between decoada and post-decoada periods were performed by Student’s t-test, principal component analysis and multivariate permutational analysis of variance (permanova). During the period of the decoada, there was a significant reduction in mean values of water transparency and concentrations of dissolved oxygen, sodium and nitrite compared to the post-decoada period. On the other hand, water temperature and conductivity, and concentrations of orthophosphate, total nitrogen and total iron have all had higher values during the decoada period. An effect of connectivity between lake and river was found to generate a gradient of water characteristics at Castelo Bay. The limnological characteristics that differed the most between decoada and post-decoada periods are those associated with the reduction of dissolved oxygen that could cause natural death of fish and the increase in nutrients during the decoada, yet they vary on temporal and spatial scales.

Hericium erinaceus, berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This ex vivo study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex® (H. erinaceus, berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-α were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex® (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-α tissue levels were evaluated at 120 minutes (T1) and 180 minutes (T2). Incubation with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-α expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex® (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase.

Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated in different cancer types, among which MM and thyroid carcinoma (THCA) are prominent. Drugs targeting mutant BRAF are effective, especially in MM patients, even though resistance rapidly develops. Previous data have linked NAMPT over-expression to the acquisition of BRAF resistance, paving the way for therapeutic strategies targeting the two pathways. Methods Exploiting the TCGA database and a collection of MM and THCA tissue microarrays we studied the association between BRAF mutations and NAMPT expression. BRAF wild-type (wt) cell lines were genetically engineered to over-express the BRAF V600E construct to demonstrate a direct relationship between over-activation of the BRAF pathway and NAMPT expression. Responses of different cell line models to NAMPT (i)nhibitors were studied using dose–response proliferation assays. Analysis of NAMPT copy number variation was performed in the TCGA dataset. Lastly, growth and colony forming assays were used to study the tumorigenic functions of NAMPT itself. Results The first finding of this work is that tumor samples carrying BRAF-mutations over-express NAMPT, as demonstrated by analyzing the TCGA dataset, and MM and THC tissue microarrays. Importantly, BRAF wt MM and THCA cell lines modified to over-express the BRAF V600E construct up-regulated NAMPT, confirming a transcriptional regulation of NAMPT following BRAF oncogenic signaling activation. Treatment of BRAF-mutated cell lines with two different NAMPTi was followed by significant reduction of tumor growth, indicating NAMPT addiction in these cells. Lastly, we found that several tumors over-expressing the enzyme, display NAMPT gene amplification. Over-expression of NAMPT in BRAF wt MM cell line and in fibroblasts resulted in increased growth capacity, arguing in favor of oncogenic properties of NAMPT. Conclusions Overall, the association between BRAF mutations and NAMPT expression identifies a subset of tumors more sensitive to NAMPT inhibition opening the way for novel combination therapies including NAMPTi with BRAFi/MEKi, to postpone and/or overcome drug resistance. Lastly, the over-expression of NAMPT in several tumors could be a key and broad event in tumorigenesis, substantiated by the finding of NAMPT gene amplification.

The currently available nebulization devices have a slow aerosol flow and produce vapor with large microdrops. Improved devices that achieve higher airflow and produce smaller microdrops are needed to improve the clinical care of patients. To address this critical need, we developed a novel system for the molecular vaporization of liquids. This device vaporizes an active pharmacological substance dissolved in water, alcohol, or a mixture of water and alcohol using two energy sources at the same time: high-frequency ultrasound and thermal induction. Application of energy to a solution contained in the device’s tank allows, within tens of seconds, for the vaporization of the solution itself, with the generation of a vapor consisting of microdrops of very small diameter (0.2–0.3 μm). In this article, we illustrate the technology used, the main verification tests performed, and the primary fields of application for this device. In particular, the advantages of both the aerosol delivery system and the administration system are highlighted.

Riverine flood risk studies often require the identification of areas prone to potential flooding. This modelling process can be based on either (hydrologically derived) flood hazard maps or (topography-based) hydrogeomorphic floodplain maps. In this paper, we derive and compare riverine flood exposure from three global products: a hydrogeomorphic floodplain map (GFPLAIN250m, hereinafter GFPLAIN) and two flood hazard maps (Flood Hazard Map of the World by the European Commission's Joint Research Centre, hereinafter JRC, and the flood hazard maps produced for the Global Assessment Report on Disaster Risk Reduction 2015, hereinafter GAR). We find an average spatial agreement between these maps of around 30 % at the river basin level on a global scale. This agreement is highly variable across model combinations and geographic conditions, influenced by climatic humidity, river volume, topography, and coastal proximity. Contrary to expectations, the agreement between the two flood hazard maps is lower compared to their agreement with the hydrogeomorphic floodplain map. We also map riverine flood exposure for 26 countries across the global south by intersecting these maps with three human population maps (Global Human Settlement population grid, hereinafter GHS; High Resolution Settlement Layer, hereinafter HRSL; and WorldPop). The findings of this study indicate that hydrogeomorphic floodplain maps can be a valuable way of producing high-resolution maps of flood-prone zones to support riverine flood risk studies, but caution should be taken in regions that are dry, steep, very flat, or near the coast.

Several materials and techniques have been described for the procedure of chest wall reconstruction: the choice of using a technique or a material over another relies mainly on the surgeon's experience as well as thoracic defect localization and dimension, local availability of materials, and costs. From a technical point of view, autologous and alloplastic reconstruction are available, and, in both cases, rigid and non-rigid prostheses are found. Each material has its peculiarities, with advantages and disadvantages; thus, it is mandatory to be confident when planning the intervention to foresee possible complications and minimize them. We have reviewed the literature on chest wall reconstruction in chest wall tumors (both malignant and non malignant) with non-rigid prosthetic materials, focusing on safety outcomes.

The effects of land use alteration, migration and urbanization are key aspects in flood management, as human activities can strongly influence the capacity of ecosystems to provide flood regulating ecosystem services and determine their demand.This study analyzes spatio–temporal dynamics of flood regulating ecosystem services to support watershed management planning. A methodology for mapping the supply and demand of flood regulation is proposed and applied to the Arno River basin, in central Italy. The spatial explicit analysis of flood regulating ecosystem services supply is carried out with SWAT - Soil and Water Assessment Tool, whose outputs are synthetized by two indicators to evaluate the retention capacity of each land use class originating from CORINE data sets. Quantification of demand for flood regulating ecosystem services is based on flood hazard classes derived from the existing local flood management plans (i.e., PAI-Piano per l’Assetto Idrogeologico and PGRA-Piano di Gestione del Rischio Alluvioni). Supply and demand data are then combined to obtain budget maps of flood regulating ecosystem services and their evolution, between 1990 and 2018. The results show how both demand and supply of ecosystem services have changed in the last decades, highlighting the main hotspots at the catchment and sub-catchment scales. With the increasing urbanization, the demand values have grown in the Arno floodplains, where residential, industrial and commercial zones are located. At the same time, land use changes have altered the water regulation supply, resulting in a generalized decrease of the basin capacity to provide flood regulation services. The maps and tables obtained show the fundamental role of forest and other vegetated areas whose protection is a priority to assure future flood regulation and associated co-benefits (e.g., regulation of air quality, reduction of erosion, improvement of water quality, wood fuel). The assessment of flood regulating here proposed is a powerful tool for decision makers to improve flood regulation and provides a sound base of knowledge to identify and locate flood prevention and mitigation measures.

The term NADome refers to the intricate network of intracellular and extracellular enzymes that regulate the synthesis or degradation of nicotinamide adenine dinucleotide (NAD) and to the receptors that engage it. Traditionally, NAD was linked to intracellular energy production through shuffling electrons between oxidized and reduced forms. However, recent data indicate that NAD, along with its biosynthetic and degrading enzymes, has a life outside of cells, possibly linked to immuno-modulating non-enzymatic activities. Extracellular NAD can engage puriginergic receptors triggering an inflammatory response, similar - to a certain extent – to what described for adenosine triphosphate (ATP). Likewise, NAD biosynthetic and degrading enzymes have been amply reported in the extracellular space, where they possess both enzymatic and non-enzymatic functions. Modulation of these enzymes has been described in several acute and chronic conditions, including obesity, cancer, inflammatory bowel diseases and sepsis. In this review, the role of the extracellular NADome will be discussed, focusing on its proposed role in immunomodulation, together with the different strategies for its targeting and their potential therapeutic impact.

Measuring electronic transport at the atomic scale requires atom precise contacts. Here, the authors demonstrate quasi-one-dimensional electronic transport along a single dimer row on a germanium surface using a two probe scanning tunneling microscopy protocol.

BackgroundMuscular fatigue and injury are frequently observed in critically ill COVID-19 patients. The aim of this study was to determine whether different muscle adipose tissue depots are associated with mortality and muscle damage in patients affected by COVID-19 admitted to the ICU.MethodsCT images were obtained in 153 ICU patients with COVID-19 (121 males and 32 females). Height, weight, body mass index (BMI), C-reactive protein, Creatine PhosphoKinase (CPK), muscle density, and intermuscular adipose tissue (IMAT) were measured.ResultsParticipants in the highest tertile of IMAT/muscle had the shorter 28-day survival from ICU admission as compared to subjects in the first tertile. Estimates derived from the Cox proportional hazard models, after adjustment for age, sex, and BMI, confirmed the results of the survival analysis (HR 3.94, 95% CI: 1.03–15.09). Participants in the lowest tertile of muscle density had the shorter survival at 28 days from ICU admission as compared to subjects in the highest tertile (HR 3.27, 95% CI: 1.18–4.61), but the relationship was no longer significant when age was included in the model. Subjects in the second muscle density tertile did not show an increased risk.Participants in the highest tertile of IMAT/muscle and those in the lowest tertile of muscle density showed both significantly higher CPK adjusted for weight values as evaluated during the first 8 days of hospitalization.ConclusionOur data seem to suggest that higher levels of IMAT/muscle and low muscle density are both associated with higher risk of ICU mortality and muscle injury as evaluated with CPK level.

Coronavirus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (named SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases is usually more susceptible to SARS-CoV-2 infection with an increased risk of severe complications and elevated case-fatality rate. Despite of several researches about COVID-19, cardiovascular implications related to this infection still remain largely unclear. The aim of this study is to evaluate the clinical characteristics of dead patients with COVID-19. We enrolled all patients with more than 50 years of age with laboratory confirmed COVID-19, admitted to infectious clinical diseases PO SS Annunziata of Chieti (Italy) from March 2020 to April 2020 who died during hospitalization. Demographics, underlying comorbidities, clinical symptoms and signs, laboratory results, computed tomography of the chest, treatment measures, and outcome data were collected. We enrolled eight patients, the age was 82 ± 9.7 years, four female and four male. All patients had comorbidity, such as hypertension (7 [87.5%]), diabetes (1 [12.5%]), and heart disease (6 [75%]). Common symptoms included fever [8 (100%)], dry cough (1[12.56%]), and dyspnea (3 [37.5%]). All patients [8 (100%)] showed local and/or bilateral patchy shadowing on chest computed tomography that is the typical radiological finding in COVID-19. Lymphopenia was observed in seven patients (87.5%). All patients showed elevated troponin and prolongation of the QTc interval ( p

Background/Objectives: A general lack of studies comparing the effect of both dynapenic abdominal obesity and sarcopenic obesity on worsening disability and hospitalization risk should be recognized. The aim of the current study was to evaluate, with a 5.5-year follow-up, the prognostic value of sarcopenic obesity and dynapenic abdominal obesity definitions on worsening disability and hospitalization risk in a sample of older adults.Subjects/Methods: In 177 women and 97 men aged 68–78 years, the following outcomes were evaluated at baseline: appendicular skeletal muscle mass (ASMM), percent fat mass (FM%), leg isometric strength, body mass index (BMI), lipid profile, vitamin D3, albumin, fibrinogen, glycemia, physical activity level, income, smoking status, and comorbidities. The rate of reported disabilities and hospitalization were also assessed at baseline, 1, 2, 3, and 5.5-years follow-up. The study population was classified into: (i) non-sarcopenic/obese (NS/O), sarcopenic/non-obese (S/NO), sarcopenic/obese (S/O), non-sarcopenic/non-obese (NS/NO, reference category) according to relative ASMM/FM% tertiles; (ii) non-dynapenic/abdominal obese (ND/AO), dynapenic/non-abdominal obese (D/NAO), dynapenic/abdominal obese (D/AO), non-dynapenic/non-abdominal obese (ND/NAO, reference category) according to muscle strength/waist circumference tertiles.Results: The prevalence of D/AO and S/O was 12.0 and 8.0%, respectively. Only 2 subjects were both D/NAO and S/O (0.8%). D/NAO subjects showed a worsening disability risk of 1.69 times (95% CI: 1.11–2.57), ND/AO subjects showed a 2-fold increased risk (95% CI: 1.34–2.98), while being D/AO more than trebled the risk, even after adjustment for confounding factors (HR: 3.39, 95%; CI: 1.91–6.02). By dividing the study population according to the relative ASMM/FM% tertiles, no groups showed an increased risk of worsening disability. The hospitalization risk, even after adjustment for potential confounders, was 1.84 (95% CI: 1.06–3.19) for D/AO. Dividing the study population according to the relative ASMM/FM% tertiles, no groups showed increased risk of hospitalization.Conclusions: Our results showed that dynapenic abdominal obesity and sarcopenic obesity seem to indicate two distinct phenotypes associated with different health risk profiles. The distribution of participants in waist circumference and muscle strength tertiles allowed for a more accurate risk stratification for worsening disability and hospitalization.

Socio-hydrology aims to understand the dynamics and co-evolution of coupled human–water systems, with research consisting of generic models as well as specific case studies. In this paper, we propose a concept to help bridge the gap between these two types of socio-hydrological studies: socio-hydrological spaces (SHSs). A socio-hydrological space is a geographical area in a landscape. Its particular combination of hydrological and social features gives rise to the emergence of distinct interactions and dynamics (patterns) between society and water. Socio-hydrological research on human–flood interactions has found two generic responses, fight or adapt. Distilling the patterns resulting from these responses in case studies provides a promising way to relate contextual specificities to the generic patterns described by conceptual models. Through the use of SHSs, different cases can be compared globally without aspiring to capturing them in a formal model. We illustrate the use of SHS for the Jamuna floodplain, Bangladesh. We use narratives and experiences of local experts and inhabitants to empirically describe and delimit SHS. We corroborated the resulting classification through the statistical analysis of primary data collected for the purpose (household surveys and focus group discussions) and secondary data (statistics, maps etc.). Our example of the use of SHSs shows that the concept draws attention to how historical patterns in the co-evolution of social behaviour, natural processes and technological interventions give rise to different landscapes, different styles of living and different ways of organising livelihoods. This provides a texture to the more generic patterns generated by socio-hydrological models, promising to make the resulting analysis more directly useful for decision makers. We propose that the usefulness of this concept in other floodplains, and for other socio-hydrological systems than floodplains, should be explored.

The aim of this research was to analyze the horizontal spatial heterogeneity of both water and superficial sediment quality among and within the reservoirs of the Cantareira System (CS), focusing on concentrations of N and P, attributed to the dumping of raw domestic sewage into water bodies, which is the main cause of water pollution in São Paulo State (Brazil). The CS is a multi-system complex composed of five interconnected reservoirs, with water transported by gravity through 48 km of tunnels and channels. From the last reservoir of the CS, with an output of 33 m3 s−1, the water is conducted to a water treatment plant, producing half of the water consumed by 19 million people inhabiting São Paulo city. The upstream reservoirs are more eutrophic than the downstream ones. Data also suggest that the low phytoplankton biomass (ranging from 0.9 to 14.4 μg dm−3) is regulated by the low nutrient availability, mainly of phosphorus (TP ranging from below the detection limit,

We reported a case of a young adult male aged 18 years admitted in our institution for syncope during a basketball match. No previous symptoms were reported. Electrocardiogram (ECG) showed T-wave inversion in the anterior leads and an incomplete right bundle branch block. Surprisingly, a complete echocardiographic evaluation demonstrated the presence of severe right ventricular enlargement with significant wall motion abnormalities, apical aneurysm and reduced systolic function. Cardiac Magnetic Resonance was pathognomonic for a fibro-fatty replacement of both ventricles. We decided for a subcutaneous defibrillator implantation and, after inducing a ventricular fibrillation to test the device status, epsilon wave appeared on the ECG. This clinical scenario depicted an advanced arrhythmogenic right ventricular cardiomyopathy at its first clinical manifestation.

In Bangladesh, socio-economic and hydrological processes are both extremely dynamic and inter-related. Human population patterns are often explained as a response, or adaptation strategy, to physical events, e.g. flooding, salt-water intrusion, and erosion. Meanwhile, these physical processes are exacerbated, or mitigated, by diverse human interventions, e.g. river diversion, levees and polders. In this context, this paper describes an attempt to explore the complex interplay between floods and societies in Bangladeshi floodplains. In particular, we performed a spatially-distributed analysis of the interactions between the dynamics of human settlements and flood inundation patterns. To this end, we used flooding simulation results from inundation modelling, LISFLOOD-FP, as well as global datasets of population distribution data, such as the Gridded Population of the World (20 years, from 1990 to 2010) and HYDE datasets (310 years, from 1700 to 2010). The outcomes of this work highlight the behaviour of Bangladeshi floodplains as complex human–water systems and indicate the need to go beyond the traditional narratives based on one-way cause–effects, e.g. climate change leading to migrations.

Este trabalho aborda a pressão antropogênica sobre corpos de água e de sua relação com os serviços ambientais associados a estes ambientes. Para tanto, toma como base a situação observada em um dos maiores remanescentes de floresta natural em área urbana do mundo, o Parque Estadual da Cantareira. Discute a relação entre a pressão antropogênica e a condição socioeconômica da população do entorno desta unidade de conservação de proteção integral ocupada por Mata Atlântica. Além disso, chama a atenção para o fato que a proteção da vegetação nem sempre resulta em proteção dos habitats aquáticos e da qualidade da água, o que interfere no uso de serviços ambientais legalmente permitidos.

Natural catastrophic events are one of most critical aspects for health and economy all around the world. However, the impact in a poor region can impact more dramatically than in others countries. Isla Hispaniola (Haiti and the Dominican Republic), one of the poorest regions of the planet, has repeatedly been hit by catastrophic natural disasters that caused incalculable human and economic losses. After the catastrophic flood event occurred in the basin of River Soliette on May 24th, 2004, the General Direction for Development and Cooperation of the Italian Department of Foreign Affairs funded an international cooperation initiative (ICI) coordinated by the University of Bologna, that involved Haitian and Dominican institutions.Main purpose of the ICI was hydrological and hydraulic analysis of the May 2004 flood event aimed at formulating a suitable and affordable flood risk mitigation plan, consisting of structural and non-structural measures. In this contest, a topographic survey was necessary to realize the hydrological model and to improve the knowledge in some areas candidates to be site for mitigation measures.To overcome the difficulties arising from the narrowness of funds, surveyors and limited time available for the survey, only GPS technique have been used, both for framing aspects (using PPP approach), and for geometrical survey of the river by means of river cross-sections and detailed surveys in two areas (RTK technique). This allowed us to reconstruct both the river geometry and the DTM’s of two expansion areas (useful for design hydraulic solutions for mitigate flood-hazard risk).

Os sedimentos têm grande importância na avaliação da contaminação e poluição dos ecossistemas aquáticos. Para avaliar a qualidade dos sedimen-tos da represa Guarapiranga aplicaram-se diferentes linhas de evidência: 1) Valores-Guia de Qualidade do Sedimento (VGQS) baseados na teoria do Equilíbrio e Partição; 2) VGQS empíricos (TEL-Threshold Effect Level; PEL-Probable Effect Level); 3) Valores de Referência Regionais (VRR) e 4) testes ecotoxicológicos (agudo/crônico) em água e sedimento. A relação ∑([MES]–[SVA])/fCOT (MES: metais extraídos simultaneamente; SVA: sulfetos volatilizáveis por acidificação; fCOT: fração carbono orgânico total) indicou toxicidade incerta nos pontos localizados à jusante na represa. Concentrações de SVA, matéria orgânica e frações silte/argila mostraram-se como potenciais fases complexadoras dos metais. Segundo VGQS empírico, a maioria dos pontos apresentou valor acima do intervalo com possíveis efeitos adversos à biota (PEL), em relação aos metais Cd, Cu, e Ni, e concentrações acima do VRR para Cd (9,7±7,2 mg/kg-1), Cu (1157,2±1125,6 mg/kg-1), Ni (38,3±28,4 mg/kg-1) e Zn (223,7±118,3 mg/kg-1). O reservatório foi dividido em dois compartimentos, que diferiram, de acordo com a PCA, quanto aos teores de Cd, Cu e profundidade, sendo que o compartimento com as maiores concentrações de metais englobou a captação de água para abastecimento público. Nos testes ecotoxicológicos, o sedimento apresentou maior potencial tóxico do que o observado em água, entretanto, esse maior potencial tóxico não pode ser atribuído apenas aos elevados teores de metais. Os resultados reforçam a necessidade do monitoramento da qualidade do sedimento e água, principalmente no que diz respeito à contaminação por Cu e Cd.

This paper offers a conceptual approach to explore the complex dynamics of floodplains as fully coupled human-water systems. A number of hydrologists have recently investigated the impact of human activities (such as flood control measures, land-use changes, and settlement patterns) on the frequency and severity of floods. Meanwhile, social scientists have shown how interactions between society and waters in deltas and floodplain areas, including the frequency and severity of floods, have an impact on the ways in which social relations unfold (in terms of governance processes, policies, and institutions) and societies are organised (spatially, politically, and socially). However, we argue that the interactions and associated feedback mechanisms between hydrological and social processes remain largely unexplored and poorly understood. Thus, there is a need to better understand how the institutions and governance processes interact with hydrological processes in deltas and floodplains to influence the frequency and severity of floods, while (in turn) hydrological processes co-constitute the social realm and make a difference for how social relations unfold to shape governance processes and institutions. Our research goal, therefore, is not in identifying one or the other side of the cycle (hydrological or social), but in explaining the relationship between them: how, when, where, and why they interact, and to what result for both social relations and hydrological processes? We argue that long time series of hydrological and social data, along with remote sensing data, can be used to observe floodplain dynamics from unconventional approaches, and understand the complex interactions between water and human systems taking place in floodplain areas, across scales and levels of human impacts, and within different hydro-climatic conditions, socio-cultural settings, and modes of governance.