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1,030 results on '"Brandes, Ralf P"'

1. RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions

Author

Weiss, Lisa M., Warwick, Timothy, Zehr, Simonida, Günther, Stefan, Wolf, Sebastian, Schmachtel, Tessa, Izquierdo Ponce, Judit, Pálfi, Katalin, Teichmann, Tom, Schneider, Alicia, Stötzel, Julia, Knapp, Stefan, Weigert, Andreas, Savai, Rajkumar, Rieger, Michael A., Oellerich, Thomas, Wittig, Ilka, Oo, James A., Brandes, Ralf P., and Leisegang, Matthias S.

Published
2024
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2. Physioxia rewires mitochondrial complex composition to protect stem cell viability

Author

Raabe, Janice, Wittig, Ilka, Laurette, Patrick, Stathopoulou, Konstantina, Brand, Theresa, Schulze, Thomas, Klampe, Birgit, Orthey, Ellen, Cabrera-Orefice, Alfredo, Meisterknecht, Jana, Thiemann, Ellen, Laufer, Sandra D., Shibamiya, Aya, Reinsch, Marina, Fuchs, Sigrid, Kaiser, Jennifer, Yang, Jiaqi, Zehr, Simonida, Wrona, Kinga M., Lorenz, Kristina, Lukowski, Robert, Hansen, Arne, Gilsbach, Ralf, Brandes, Ralf P., Ulmer, Bärbel M., Eschenhagen, Thomas, and Cuello, Friederike

Published
2024
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5. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function

Author

Boos, Frederike, Oo, James A., Warwick, Timothy, Günther, Stefan, Izquierdo Ponce, Judit, Lopez, Melina, Rafii, Diba, Buchmann, Giulia, Pham, Minh Duc, Msheik, Zahraa S., Li, Tianfu, Seredinski, Sandra, Haydar, Shaza, Kashefiolasl, Sepide, Plate, Karl H., Behr, Rüdiger, Mietsch, Matthias, Krishnan, Jaya, Pullamsetti, Soni S., Bibli, Sofia-Iris, Hinkel, Rabea, Baker, Andrew H., Boon, Reinier A., Schulz, Marcel H., Wittig, Ilka, Miller, Jr., Francis J., Brandes, Ralf P., and Leisegang, Matthias S.

Published
2023
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7. Abstract 12226: Aging Impairs the Neuro-Vascular Interface in the Heart

Author

Wagner, Julian U, Tombor, Lukas, Malacarne, Pedro F, Manickam, Nivethitha, Abplanalp, Wesley T, John, David, Buchmann, Giulia Karolin K, Angendohr, Stephan, Amin, Ehsan, Scherschel, Katharina, Nikolaj, Klöcker, Kelm, Malte, Schüttler, Dominik, Clauss, Sebastian, Guenther, Stefan, Braun, Thomas, Boettger, Thomas, Baer, Christian, Pham, Minh-Duc, Krishnan, Jaya, Hille, Susanne S, Mueller, Oliver, Bozoglu, Tarik, Kupatt, Christian, Nardini, Eleonora, Osmanagic-Myers, Selma, Meyer, Christian, Zeiher, Andreas M, Brandes, Ralf P, Luxan, Guillermo, and Dimmeler, Stefanie

Published
2023
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9. HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Author

Leisegang, Matthias S., Bains, Jasleen Kaur, Seredinski, Sandra, Oo, James A., Krause, Nina M., Kuo, Chao-Chung, Günther, Stefan, Sentürk Cetin, Nevcin, Warwick, Timothy, Cao, Can, Boos, Frederike, Izquierdo Ponce, Judit, Haydar, Shaza, Bednarz, Rebecca, Valasarajan, Chanil, Fuhrmann, Dominik C., Preussner, Jens, Looso, Mario, Pullamsetti, Soni S., Schulz, Marcel H., Jonker, Hendrik R. A., Richter, Christian, Rezende, Flávia, Gilsbach, Ralf, Pflüger-Müller, Beatrice, Wittig, Ilka, Grummt, Ingrid, Ribarska, Teodora, Costa, Ivan G., Schwalbe, Harald, and Brandes, Ralf P.

Published
2022
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10. Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors

Author

Helfinger, Valeska, von Gall, Florian Freiherr, Henke, Nina, Kunze, Michael M., Schmid, Tobias, Rezende, Flavia, Heidler, Juliana, Wittig, Ilka, Radeke, Heinfried H., Marschall, Viola, Anderson, Karen, Shah, Ajay M., Fulda, Simone, Brüne, Bernhard, Brandes, Ralf P., and Schröder, Katrin

Published
2021

12. LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses.

Author

Lam, Frederike, Leisegang, Matthias S., and Brandes, Ralf P.

Subjects
TRANSCRIPTION factors, LINCRNA, VASCULAR endothelium, SHEARING force, GENETIC transcription regulation, PROTEIN stability
Abstract

The functional role of long noncoding RNAs in the endothelium is highly diverse. Among their many functions, regulation of transcription factor activity and abundance is one of the most relevant. This review summarizes the recent progress in the research on the lncRNA–transcription factor axes and their implications for the vascular endothelium under physiological and pathological conditions. The focus is on transcription factors critical for the endothelial response to external stressors, such as hypoxia, inflammation, and shear stress, and their lncRNA interactors. These regulatory interactions will be exemplified by a selected number of lncRNAs that have been identified in the endothelium under physiological and pathological conditions that are influencing the activity or protein stability of important transcription factors. Thus, lncRNAs can add a layer of cell type-specific function to transcription factors. Understanding the interaction of lncRNAs with transcription factors will contribute to elucidating cardiovascular disease pathologies and the development of novel therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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14. IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors

Author

Gupta, Sahil, Jain, Arpit, Syed, Shahzad Nawaz, Snodgrass, Ryan G, Pflüger-Müller, Beatrice, Leisegang, Matthias S, Weigert, Andreas, Brandes, Ralf P, Ebersberger, Ingo, Brüne, Bernhard, and Namgaladze, Dmitry

Subjects
Biomedical and Clinical Sciences, Immunology, Genetics, Breast Cancer, Cancer, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, primary human monocyte derived macrophages, interleukins, RNA sequencing, signal transducer and activator of transcription, basic leucine zipper ATF-like transcription factor, CRISPR interference, Oncology and Carcinogenesis, Oncology and carcinogenesis
Abstract

Macrophages in the tumor microenvironment respond to complex cytokine signals. How these responses shape the phenotype of tumor-associated macrophages (TAMs) is incompletely understood. Here we explored how cytokines of the tumor milieu, interleukin (IL)-6 and IL-4, interact to influence target gene expression in primary human monocyte-derived macrophages (hMDMs). We show that dual stimulation with IL-4 and IL-6 synergistically modified gene expression. Among the synergistically induced genes are several targets with known pro-tumorigenic properties, such as CC-chemokine ligand 18 (CCL18), transforming growth factor alpha (TGFA) or CD274 (programmed cell death 1 ligand 1 (PD-L1)). We found that transcription factors of the signal transducer and activator of transcription (STAT) family, STAT3 and STAT6 bind regulatory regions of synergistically induced genes in close vicinity. STAT3 and STAT6 co-binding further induces the basic leucine zipper ATF-like transcription factor (BATF), which participates in synergistic induction of target gene expression. Functional analyses revealed increased MCF-7 and MDA-MB 231 tumor cell motility in response to conditioned media from co-treated hMDMs compared to cells incubated with media from single cytokine-treated hMDMs. Flow cytometric analysis of T cell populations upon co-culture with hMDMs polarized by different cytokines indicated that dual stimulation promoted immunosuppressive properties of hMDMs in a PD-L1-dependent manner. Analysis of clinical data revealed increased expression of BATF together with TAM markers in tumor stroma of breast cancer patients as compared to normal breast tissue stroma. Collectively, our findings suggest that IL-4 and IL-6 cooperate to alter the human macrophage transcriptome, endowing hMDMs with pro-tumorigenic properties.

Published
2018

15. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Author

Hitzel, Juliane, Lee, Eunjee, Zhang, Yi, Bibli, Sofia Iris, Li, Xiaogang, Zukunft, Sven, Pflüger, Beatrice, Hu, Jiong, Schürmann, Christoph, Vasconez, Andrea Estefania, Oo, James A, Kratzer, Adelheid, Kumar, Sandeep, Rezende, Flávia, Josipovic, Ivana, Thomas, Dominique, Giral, Hector, Schreiber, Yannick, Geisslinger, Gerd, Fork, Christian, Yang, Xia, Sigala, Fragiska, Romanoski, Casey E, Kroll, Jens, Jo, Hanjoong, Landmesser, Ulf, Lusis, Aldons J, Namgaladze, Dmitry, Fleming, Ingrid, Leisegang, Matthias S, Zhu, Jun, and Brandes, Ralf P

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cardiovascular, Clinical Research, Aging, Heart Disease, Atherosclerosis, Genetics, Heart Disease - Coronary Heart Disease, 2.1 Biological and endogenous factors, Amino Acids, Aminohydrolases, Animals, Aorta, Bayes Theorem, Cardiovascular Diseases, Endothelial Cells, Gene Expression Regulation, Genetic Techniques, Glycine, Human Umbilical Vein Endothelial Cells, Humans, Methylenetetrahydrofolate Dehydrogenase (NADP), Multifunctional Enzymes, Multigene Family, Neovascularization, Pathologic, Nucleotides, Oxygen, Phospholipids, Probability, Purines, RNA, Small Interfering, Zebrafish
Abstract

Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene network regulating serine-glycine metabolism with the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) as a causal regulator using integrative network modeling and Bayesian network analysis in human aortic endothelial cells. The cluster is activated in human plaque material and by atherogenic lipoproteins isolated from plasma of patients with coronary artery disease (CAD). Single nucleotide polymorphisms (SNPs) within the MTHFD2-controlled cluster associate with CAD. The MTHFD2-controlled cluster redirects metabolism to glycine synthesis to replenish purine nucleotides. Since endothelial cells secrete purines in response to oxPAPC, the MTHFD2-controlled response maintains endothelial ATP. Accordingly, MTHFD2-dependent glycine synthesis is a prerequisite for angiogenesis. Thus, we propose that endothelial cells undergo MTHFD2-mediated reprogramming toward serine-glycine and mitochondrial one-carbon metabolism to compensate for the loss of ATP in response to oxPAPC during atherosclerosis.

Published
2018

16. The aging-induced long non-coding RNAMIRIALcontrols endothelial cell and mitochondrial function

Author

Kohnle, Caroline, primary, Koziarek, Susanne, additional, Warwick, Timothy, additional, Theodorou, Kosta, additional, Fischer, Ariane, additional, Juni, Rio Putra, additional, Muhly-Reinholz, Marion, additional, Busscher, Denise, additional, Lam, Frederike, additional, Vetter, Felix, additional, Wagner, Julian U. G., additional, Sommer, Janina, additional, Gimbel, Anna Theresa, additional, Stanicek, Laura, additional, Günther, Stefan, additional, Wittig, Ilka, additional, Maegdefessel, Lars, additional, Leisegang, Matthias S., additional, Brandes, Ralf P., additional, Dimmeler, Stefanie, additional, and Boon, Reinier A., additional

Published
2024
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18. NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4.

Author

Singh, Anand, Koduru, Bhargav, Carlisle, Cameron, Akhter, Hasina, Liu, Rui-Ming, Schroder, Katrin, Brandes, Ralf P, and Ojcius, David M

Subjects
Liver, Cell Line, Tumor, Hepatocytes, Animals, Mice, Inbred C57BL, Humans, Mice, Carcinoma, Hepatocellular, Liver Neoplasms, Reactive Oxygen Species, Lipopolysaccharides, Signal Transduction, Toll-Like Receptor 4, NADPH Oxidase 4, NADPH Oxidases, Carcinoma, Hepatocellular, Cell Line, Tumor, Inbred C57BL
Abstract

Chronic inflammation plays a key role in development of many liver diseases. Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysaccharide (LPS) initiates inflammation and promotes development of hepatocellular carcinoma and other liver diseases. NADPH oxidases contribute to LPS-induced reactive oxygen species (ROS) production and modulate TLR responses, but whether these enzymes function in TLR4 responses of hepatocytes is unknown. In the present work, we examined the role of NADPH oxidase 4 (Nox4) in LPS-induced TLR4 responses in human hepatoma cells and wildtype and Nox4-deficient mice. We found that LPS increased expression of Nox4, TNF-α, and proliferating cell nuclear antigen (PCNA). Nox4 silencing suppressed LPS-induced TNF-α and PCNA increases in human cells. The LPS-induced TNF-α increases were MyD88-dependent, and were attenuated in primary hepatocytes isolated from Nox4-deficient mice. We found that Nox4 mediated LPS-TLR4 signaling in hepatocytes via NF-ĸB and AP-1 pathways. Moreover, the effect of Nox4 depletion was time-dependent; following six weeks of repeated LPS stimulation in vivo, hepatic TNF-α and PCNA responses subsided in Nox4-deficient mice compared with wildtype mice. Therefore, our data suggest that Nox4 mediates LPS-TLR4 signaling in human hepatoma cells and murine hepatocytes and may contribute to the ability of LPS to stimulate liver pathology.

Published
2017

19. NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease

Author

Sasaki, Yu, Dehnad, Ali, Fish, Sarah, Sato, Ai, Jiang, Joy, Tian, Jijing, Schröder, Kathrin, Brandes, Ralf, and Török, Natalie J

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Alcoholism, Alcohol Use and Health, Digestive Diseases, Liver Disease, Chronic Liver Disease and Cirrhosis, Substance Misuse, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Acetaldehyde, Alcohol Drinking, Animals, Cell Nucleus, Cells, Cultured, Chemokine CCL2, ELAV-Like Protein 1, Hepatic Stellate Cells, Humans, Inflammation Mediators, Liver Diseases, Alcoholic, Mice, Inbred C57BL, Mice, Knockout, NADPH Oxidase 4, Protein Transport, RNA Stability, Receptors, CCR2
Abstract

Recruitment of inflammatory cells is a major feature of alcoholic liver injury however; the signals and cellular sources regulating this are not well defined. C-C chemokine receptor type 2 (CCR2) is expressed by active hepatic stellate cells (HSC) and is a key monocyte recruitment signal. Activated HSC are also important sources of hydrogen peroxide resulting from the activation of NADPH oxidase 4 (NOX4). As the role of this NOX in early alcoholic liver injury has not been addressed, we studied NOX4-mediated regulation of CCR2/CCL2 mRNA stability. NOX4 mRNA was significantly induced in patients with alcoholic liver injury, and was co-localized with αSMA-expressing activated HSC. We generated HSC-specific NOX4 KO mice and these were pair-fed on alcohol diet. Lipid peroxidation have not changed significantly however, the expression of CCR2, CCL2, Ly6C, TNFα, and IL-6 was significantly reduced in NOX4HSCKO compared to fl/fl mice. NOX4 promoter was induced in HSC by acetaldehyde treatment, and NOX4 has significantly increased mRNA half-life of CCR2 and CCL2 in conjunction with Ser221 phosphorylation and cytoplasmic shuttling of HuR. In conclusion, NOX4 is induced in early alcoholic liver injury and regulates CCR2/CCL2 mRNA stability thereby promoting recruitment of inflammatory cells and production of proinflammatory cytokines.

Published
2017

23. NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Author

Seimetz, Michael, Sommer, Natascha, Bednorz, Mariola, Pak, Oleg, Veith, Christine, Hadzic, Stefan, Gredic, Marija, Parajuli, Nirmal, Kojonazarov, Baktybek, Kraut, Simone, Wilhelm, Jochen, Knoepp, Fenja, Henneke, Ingrid, Pichl, Alexandra, Kanbagli, Zeki I., Scheibe, Susan, Fysikopoulos, Athanasios, Wu, Cheng-Yu, Klepetko, Walter, Jaksch, Peter, Eichstaedt, Christina, Grünig, Ekkehard, Hinderhofer, Katrin, Geiszt, Miklós, Müller, Niklas, Rezende, Flavia, Buchmann, Giulia, Wittig, Ilka, Hecker, Matthias, Hecker, Andreas, Padberg, Winfried, Dorfmüller, Peter, Gattenlöhner, Stefan, Vogelmeier, Claus F., Günther, Andreas, Karnati, Srikanth, Baumgart-Vogt, Eveline, Schermuly, Ralph T., Ghofrani, Hossein A., Seeger, Werner, Schröder, Katrin, Grimminger, Friedrich, Brandes, Ralf P., and Weissmann, Norbert

Published
2020
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29. Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory.

Author

Hernandez Torres, Luis Daniel, Rezende, Flavia, Peschke, Eva, Will, Olga, Hövener, Jan-Bernd, Spiecker, Frauke, Özorhan, Ümit, Lampe, Josephine, Stölting, Ines, Aherrahrou, Zouhair, Künne, Carsten, Kusche-Vihrog, Kristina, Matschl, Urte, Hille, Susanne, Brandes, Ralf P., Schwaninger, Markus, Müller, Oliver J., and Raasch, Walter

Subjects
MICROCIRCULATION disorders, CEREBRAL circulation, MAZE tests, BLOOD flow, CINGULATE cortex, WESTERN diet
Abstract

Introduction: The development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice. Methods: We induced atherosclerosis in male C57BL/6N mice by injecting AAV-PCSK9DY (2x1011 VG) and feeding them a cholesterol-rich Western diet. After 3 months, mice were examined for cognition using Barnes maze procedure and for cerebral blood flow. Cerebral vascular morphology was examined by immunehistology. Results: In AAV-PCSK9DY-treated mice, plaque burden, plasma cholesterol, and triglycerides are elevated. RNAseq analyses followed by KEGG annotation show increased expression of genes linked to inflammatory processes in the aortas of these mice. In AAV-PCSK9DY-treated mice learning was delayed and long-term memory impaired. Blood flow was reduced in the cingulate cortex (-17%), caudate putamen (-15%), and hippocampus (-10%). Immunohistological studies also show an increased incidence of string vessels and pericytes (CD31/Col IV staining) in the hippocampus accompanied by patchy blood-brain barrier leaks (IgG staining) and increased macrophage infiltrations (CD68 staining). Discussion: We conclude that the hyperlipidemic PCSK9DY mouse model can serve as an appropriate approach to induce microvascular dysfunction that leads to reduced blood flow in the hippocampus, which could explain the cognitive dysfunction in these mice. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence

Author

Hu, Jiong, primary, Leisegang, Matthias S., additional, Looso, Mario, additional, Drekolia, Maria-Kyriaki, additional, Wittig, Janina, additional, Mettner, Janina, additional, Karantanou, Christina, additional, Kyselova, Anastasia, additional, Dumbovic, Gabrjela, additional, Li, Xiaoming, additional, Li, Yuanyuan, additional, Guenther, Stefan, additional, John, David, additional, Siragusa, Mauro, additional, Zukunft, Sven, additional, Oo, James A., additional, Wittig, Ilka, additional, Hille, Susanne, additional, Weigert, Andreas, additional, Knapp, Stefan, additional, Brandes, Ralf P., additional, Müller, Oliver J., additional, Papapetropoulos, Andreas, additional, Sigala, Fragiska, additional, Dobreva, Gergana, additional, Kojonazarov, Baktybek, additional, Fleming, Ingrid, additional, and Bibli, Sofia-Iris, additional

Published
2023
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31. Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species

Author

Pak, Oleg, Sydykov, Akylbek, Kosanovic, Djuro, Schermuly, Ralph T., Dietrich, Alexander, Schröder, Katrin, Brandes, Ralf P., Gudermann, Thomas, Sommer, Natascha, Weissmann, Norbert, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, REZAEI, NIMA, Series editor, and Wang, Yong-Xiao, editor

Published
2017
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37. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Author

Trembinski, D. Julia, Bink, Diewertje I., Theodorou, Kosta, Sommer, Janina, Fischer, Ariane, van Bergen, Anke, Kuo, Chao-Chung, Costa, Ivan G., Schürmann, Christoph, Leisegang, Matthias S., Brandes, Ralf P., Alekseeva, Tijna, Brill, Boris, Wietelmann, Astrid, Johnson, Christopher N., Spring-Connell, Alexander, Kaulich, Manuel, Werfel, Stanislas, Engelhardt, Stefan, Hirt, Marc N., Yorgan, Kaja, Eschenhagen, Thomas, Kirchhof, Luisa, Hofmann, Patrick, Jaé, Nicolas, Wittig, Ilka, Hamdani, Nazha, Bischof, Corinne, Krishnan, Jaya, Houtkooper, Riekelt H., Dimmeler, Stefanie, and Boon, Reinier A.

Published
2020
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40. CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD

Author

Wu, Cheng-Yu, primary, Cilic, Anis, additional, Pak, Oleg, additional, Dartsch, Ruth Charlotte, additional, Wilhelm, Jochen, additional, Wujak, Magdalena, additional, Lo, Kevin, additional, Brosien, Monika, additional, Zhang, Ruoyu, additional, Alkoudmani, Ibrahim, additional, Witte, Biruta, additional, Pedersen, Frauke, additional, Watz, Henrik, additional, Voswinckel, Robert, additional, Günther, Andreas, additional, Ghofrani, Hossein A, additional, Brandes, Ralf P, additional, Schermuly, Ralph T, additional, Grimminger, Friedrich, additional, Seeger, Werner, additional, Sommer, Natascha, additional, Weissmann, Norbert, additional, and Hadzic, Stefan, additional

Published
2023
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41. Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species

Author

Vogel, Alexandra, primary, Ueberbach, Timo, additional, Wilken-Schmitz, Annett, additional, Hahnefeld, Lisa, additional, Franck, Luisa, additional, Weyer, Marc-Philipp, additional, Jungenitz, Tassilo, additional, Schmid, Tobias, additional, Buchmann, Giulia, additional, Freudenberg, Florian, additional, Brandes, Ralf P., additional, Gurke, Robert, additional, Schwarzacher, Stephan W., additional, Geisslinger, Gerd, additional, Mittmann, Thomas, additional, and Tegeder, Irmgard, additional

Published
2023
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42. Nicotine promotes e-cigarette vapour-induced lung inflammation and structural alterations

Author

Roxlau, Elsa T., primary, Pak, Oleg, additional, Hadzic, Stefan, additional, Garcia-Castro, Claudia F., additional, Gredic, Marija, additional, Wu, Cheng-Yu, additional, Schäffer, Julia, additional, Selvakumar, Balachandar, additional, Pichl, Alexandra, additional, Spiegelberg, David, additional, Deutscher, Janik, additional, Bednorz, Mariola, additional, Schäfer, Katharina, additional, Kraut, Simone, additional, Kosanovic, Djuro, additional, Zeidan, Esraa M, additional, Kojonazarov, Baktybek, additional, Herold, Susanne, additional, Strielkov, Ievgen, additional, Guenther, Andreas, additional, Wilhelm, Jochen, additional, Khalifa, Mohamed M. A., additional, Taye, Ashraf, additional, Brandes, Ralf P., additional, Hecker, Matthias, additional, Grimminger, Friedrich, additional, Ghofrani, Hossein A., additional, Schermuly, Ralph T., additional, Seeger, Werner, additional, Sommer, Natascha, additional, and Weissmann, Norbert, additional

Published
2023
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43. Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells

Author

Gimenez, Marcela, Veríssimo-Filho, Sidney, Wittig, Ilka, Schickling, Brandon M., Hahner, Fabian, Schürmann, Christoph, Netto, Luis E.S., Rosa, José César, Brandes, Ralf P., Sartoretto, Simone, De Lucca Camargo, Lívia, Abdulkader, Fernando, Miller, Francis J., Jr, and Lopes, Lucia Rossetti

Published
2019
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44. Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

Author

Bibli, Sofia-Iris, Hu, Jiong, Sigala, Fragiska, Wittig, Ilka, Heidler, Juliana, Zukunft, Sven, Tsilimigras, Diamantis I., Randriamboavonjy, Voahanginirina, Wittig, Janina, Kojonazarov, Baktybek, Schürmann, Christoph, Siragusa, Mauro, Siuda, Daniel, Luck, Bert, Abdel Malik, Randa, Filis, Konstantinos A., Zografos, George, Chen, Chen, Wang, Dao Wen, Pfeilschifter, Josef, Brandes, Ralf P., Szabo, Csaba, Papapetropoulos, Andreas, and Fleming, Ingrid

Published
2019
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45. Repetitive and compulsive behavior after Early-Life-Pain in mice

Author

Vogel, Alexandra, primary, Ueberbach, Timo, additional, Wilken-Schmitz, Annett, additional, Hahnefeld, Lisa, additional, Franck, Luisa, additional, Weyer, Marc-Philipp, additional, Jungenitz, Tassilo, additional, Schmid, Tobias, additional, Buchmann, Giulia, additional, Freudenberg, Florian, additional, Brandes, Ralf P., additional, Gurke, Robert, additional, Schwarzacher, Stephan W., additional, Geisslinger, Gerd, additional, Mittmann, Thomas, additional, and Tegeder, Irmgard, additional

Published
2023
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46. Acute injury to the mouse carotid artery provokes a distinct healing response

Author

Warwick, Timothy, primary, Buchmann, Giulia Karolin, additional, Pflüger-Müller, Beatrice, additional, Spaeth, Manuela, additional, Schürmann, Christoph, additional, Abplanalp, Wesley, additional, Tombor, Lukas, additional, John, David, additional, Weigert, Andreas, additional, Leo-Hansmann, Martin, additional, Dimmeler, Stefanie, additional, and Brandes, Ralf P., additional

Published
2023
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48. Endothelial deletion of the cytochrome P450 reductase leads to cardiac remodelling

Author

Lopez, Melina, primary, Malacarne, Pedro F., additional, Ramanujam, Deepak P., additional, Warwick, Timothy, additional, Müller, Niklas, additional, Hu, Jiong, additional, Dewenter, Matthias, additional, Weigert, Andreas, additional, Günther, Stefan, additional, Gilsbach, Ralf, additional, Engelhardt, Stefan, additional, Brandes, Ralf P., additional, and Rezende, Flávia, additional

Published
2022
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49. The lncRNA landscape of cardiac resident macrophages and identification ofSchlafenlncas a regulator of macrophage migratory function

Author

Dueck, Anne, primary, Althaus, Lara, additional, Heise, Kathrin, additional, Esfandyari, Dena, additional, Baygün, Seren, additional, Brandes, Ralf P., additional, Gagneur, Julien, additional, Jaé, Nicolas, additional, Knolle, Percy, additional, Leisegang, Matthias S., additional, Maegdefessel, Lars, additional, Meitinger, Thomas, additional, Petzold, Niklas, additional, Ramanujam, Deepak, additional, Sager, Hendrik, additional, Schulz, Christian, additional, Theodorakis, Evangelos, additional, Uzonyi, Anna, additional, Weinberger, Tobias, additional, Bader, Michael, additional, Schmidt-Supprian, Marc, additional, and Engelhardt, Stefan, additional

Published
2022
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50. Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Author

Seimetz, Michael, Sommer, Natascha, Bednorz, Mariola, Pak, Oleg, Veith, Christine, Hadzic, Stefan, Gredic, Marija, Parajuli, Nirmal, Kojonazarov, Baktybek, Kraut, Simone, Wilhelm, Jochen, Knoepp, Fenja, Henneke, Ingrid, Pichl, Alexandra, Kanbagli, Zeki I., Scheibe, Susan, Fysikopoulos, Athanasios, Wu, Cheng-Yu, Klepetko, Walter, Jaksch, Peter, Eichstaedt, Christina, Grünig, Ekkehard, Hinderhofer, Katrin, Geiszt, Miklós, Müller, Niklas, Rezende, Flavia, Buchmann, Giulia, Wittig, Ilka, Hecker, Matthias, Hecker, Andreas, Padberg, Winfried, Dorfmüller, Peter, Gattenlöhner, Stefan, Vogelmeier, Claus F., Günther, Andreas, Karnati, Srikanth, Baumgart-Vogt, Eveline, Schermuly, Ralph T., Ghofrani, Hossein A., Seeger, Werner, Schröder, Katrin, Grimminger, Friedrich, Brandes, Ralf P., and Weissmann, Norbert

Published
2020
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