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1. A multicomponent intervention program modifies the cluster of insulin biomarkers, body composition, physical fitness, and behaviors in adolescents with overweight and obesity: a network perspective

Author

Schneiders, Letícia Borba, Bandeira, Paulo Felipe Ribeiro, Gaya, Anelise Reis, Àlvarez, Cristian, Brazo-Sayavera, Javier, Cristi-Montero, Carlos, Borfe, Leticia, Fochessato, Camila Felin, Brand, Caroline, Corbellini, Valeriano Antonio, Renner, Jane Dagmar Pollo, and Reuter, Cézane Priscila

Published
2024
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12. CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

Author

Altvater, Bianca, Kailayangiri, Sareetha, Spurny, Christian, Flügge, Maike, Meltzer, Jutta, Greune, Lea, Urban, Katja, Schwöppe, Christian, Brand, Caroline, Schliemann, Christoph, Hintelmann, Heike, Harrach, Saliha, Hartmann, Wolfgang, Abken, Hinrich, Kuehle, Johannes, Schambach, Axel, Görlich, Dennis, Berdel, Wolfgang E., and Rossig, Claudia

Published
2023
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13. Targeted siRNA nanocarrier: a platform technology for cancer treatment

Author

Bäumer, Nicole, Tiemann, Jessica, Scheller, Annika, Meyer, Theresa, Wittmann, Lisa, Suburu, Matias Ezequiel Gutierrez, Greune, Lilo, Peipp, Matthias, Kellmann, Neele, Gumnior, Annika, Brand, Caroline, Hartmann, Wolfgang, Rossig, Claudia, Müller-Tidow, Carsten, Neri, Dario, Strassert, Cristian A, Rüter, Christian, Dersch, Petra, Lenz, Georg, Koeffler, H Phillip, Berdel, Wolfgang E, and Bäumer, Sebastian

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Medical Biotechnology, Oncology and Carcinogenesis, Rare Diseases, Lung Cancer, Genetics, Biotechnology, Lung, Nanotechnology, Cancer, Bioengineering, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Male, Oncogene Proteins, Fusion, Protamines, Proto-Oncogene Protein c-fli-1, RNA, Small Interfering, RNA-Binding Protein EWS, Technology, Xenograft Model Antitumor Assays, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

The small arginine-rich protein protamine condenses complete genomic DNA into the sperm head. Here, we applied its high RNA binding capacity for spontaneous electrostatic assembly of therapeutic nanoparticles decorated with tumour-cell-specific antibodies for efficiently targeting siRNA. Fluorescence microscopy and DLS measurements of these nanocarriers revealed the formation of a vesicular architecture that requires presence of antibody-protamine, defined excess of free SMCC-protamine, and anionic siRNA to form. Only these complex nanoparticles were efficient in the treatment of non-small-cell lung cancer (NSCLC) xenograft models, when the oncogene KRAS was targeted via EGFR-mediated delivery. To show general applicability, we used the modular platform for IGF1R-positive Ewing sarcomas. Anti-IGR1R-antibodies were integrated into an antibody-protamine nanoparticle with an siRNA specifically against the oncogenic translocation product EWS/FLI1. Using these nanoparticles, EWS/FLI1 knockdown blocked in vitro and in vivo growth of Ewing sarcoma cells. We conclude that these antibody-protamine-siRNA nanocarriers provide a novel platform technology to specifically target different cell types and yet undruggable targets in cancer therapy by RNAi.

Published
2022

15. The Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents: A modified Delphi consensus project with 169 experts from 50 countries and territories

Author

Oyeyemi, Adewale L., Marques, Adilson, Gribbon, Aidan, Gaya, Anelise Reis Reis, García-Hermoso, Antonio, Sääkslahti, Arja, Faigenbaum, Avery, Nakabazzi, Bernadette, Leskošek, Bojan, Popovic, Boris, O'Keeffe, Brendan, Timmons, Brian W., Mieziene, Brigita, Fraser, Brooklyn, Brand, Caroline, Anza-Ramirez, Cecilia, Alvarez-Bueno, Celia, Agostinis-Sobrinho, Cesar A., Hillman, Charles H., Niessner, Claudia, Drenowatz, Clemens, Magnussen, Costan G., Cadenas-Sanchez, Cristina, Berglind, Daniel, da Silva, Danilo Rodrigues Pereira, Colella, Dario, Lubans, David, Matelot, David, Tladi, Dawn M., Silva, Diego Augusto Santos, Moliner-Urdiales, Diego, Dumuid, Dot, Blain, Dylan, Ulloa, Edtna Jáuregui, Arunas, Emeljanovas, Pintos-Toledo, Enrique, Poon, Eric Tsz Chun, Lee, Eun-Young, Riso, Eva Maria, Mäestu, Evelin, Bardid, Farid, Cañete, Felicia, Rodríguez, Fernando Rodríguez, De Roia, Gabriela, Tabacchi, Garden, Stratton, Gareth, Sandercock, Gavin R., Georgiev, Georgi, Vicente-Rodríguez, Germán, Ferrari, Gerson, Rosa, Gil, Welk, Greg, Jurak, Gregor, Starc, Gregor, Labayen, Idoia, Cigarroa, Igor, Esteban-Cornejo, Irene, Emeterio, Iván Clavel San, Milanović, Ivana, Clarke, Janine, Dobosz, Janusz, Mäestu, Jarek, Brazo-Sayavera, Javier, Sacheck, Jennifer, Servais, Jennifer, Secchi, Jeremías David, Vanhelst, Jérémy, Ramírez, Jesús Viciana, Magalhães, João, Soto-Sánchez, Johana, Jaunig, Johannes, Reilly, John J., Smith, Jordan, Mota, Jorge, Castro-Piñero, Jose, López-Gil, José Francisco, Githang'a, Juliah Wambui, Mello, Júlio Brugnara, Janz, Kathleen, Weston, Kathryn L., Laurson, Kelly, Till, Kevin, Dlamini, Khanyile, Tambalis, Konstantinos D., Basterfield, Laura, Joensuu, Laura, Béghin, Laurent, Santos, Leandro dos, Mugisha, Lillian, Zou, Liye, Taylor, Juan Ricardo López Y, Štefan, Lovro, Léger, Luc, Wachira, Lucy-Joy, Sardinha, Luís B., Rubin, Lukas, Thuany, Mabliny, Cuenca-García, Magdalena, Paw, Mai Chin A, Sanchez-Lopez, Mairena, Pihu, Maret, Noriega, Maria Jose, Medrano-Echeverría, María, Beltran-Valls, Maria Reyes, Löf, Marie, Misigoj-Durakovic, Marjeta, Tremblay, Mark, Gerber, Markus, Sorić, Maroje, Giuriato, Matteo, Vandoni, Matteo, Lenoir, Matthieu, Santander, Mauro D., Peralta, Miguel, Huhtiniemi, Mikko, Said, Mohamed Ahmed, Kaj, Mónika, Burn, Naomi, Ridgers, Nicola D., Lovecchio, Nicola, Aguilar-Farias, Nicolas, Wedderkopp, Niels, Veiga, Oscar L., Saint-Maurice, Pedro, Katzmarzyk, Peter, Henriksson, Pontus, Colley, Rachel, Ocansey, Reginald T-A., Kliegl, Reinhold, Ramírez-Vélez, Robinson, Ssenyonga, Ronald, Naidoo, Rowena, Pate, Russell R., McGrath, Ryan, Kuu, Saima, Salaj, Sanja, Gontarev, Seryozha, Morrison, Shawnda A., Nqweniso, Siphesihle, Chen, Sitong, Kagunda, Stanley, Ware, Stephanie Prince, Wong, Stephen H., Popovic, Stevo R., Fairclough, Stuart J., Andrade, Susana, Kriemler, Susi, Csányi, Tamás, Manyanga, Taru, Mwase-Vuma, Tawonga W., Kidokoro, Tetsu, Gomes, Thayse Natacha, Gisladottir, Thordis, Takken, Tim, Jaakkola, Timo, Lakka, Timo, Olds, Timothy, Tammelin, Tuija, Granacher, Urs, Carson, Valerie, Martinez-Vizcaino, Vincent, Onywera, Vincent, Pellino, Vittoria Carnevale, Huang, Wendy Y., Yin, Xiaojian, Liu, Yang, Song, Yi, Sun, Yi, Liu, Yuan, Ortega, Francisco B., Zhang, Kai, Tremblay, Mark S., Tomkinson, Grant R., Ruiz, Jonatan R., Keller, Katja, Nyström, Christine Delisle, Pate, Russell, Kidokoro, Tetsuhiro, Poon, Eric, Wachira, Lucy-Joy M., Gomes, Thayse Natacha Q.F., Cristi-Montero, Carlos, Fraser, Brooklyn J., Onywera, Vincent O., Liang, Li-Lin, Prince, Stephanie A., Lubans, David R., and Lang, Justin J.

Published
2024
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16. The Longitudinal Association of Cardiorespiratory Fitness and Adiposity With Clustered Cardiometabolic Risk: A Mediation Analysis.

Author

Silveira, João Francisco de Castro, Brand, Caroline, Welser, Letícia, Gaya, Anelise Reis, Burns, Ryan Donald, Pfeiffer, Karin Allor, Lima, Rodrigo Antunes, Andersen, Lars Bo, Reuter, Cézane Priscila, and Pohl, Hildegard Hedwig

Subjects
BLOOD sugar analysis, CARDIOPULMONARY fitness, RISK assessment, SELF-evaluation, EFFECT sizes (Statistics), STATISTICAL correlation, HDL cholesterol, ADIPOSE tissues, BODY mass index, T-test (Statistics), RESEARCH funding, SCIENTIFIC observation, STATISTICAL sampling, RUNNING, QUESTIONNAIRES, CARDIOVASCULAR diseases risk factors, PATH analysis (Statistics), DESCRIPTIVE statistics, BRAZILIANS, LONGITUDINAL method, WALKING, RESEARCH, FIELD research, CHOLESTEROL, CHILDHOOD obesity, FACTOR analysis, EXERCISE tests, DATA analysis software, CONFIDENCE intervals, SYSTOLIC blood pressure, TRIGLYCERIDES, DISEASE complications, ADOLESCENCE, CHILDREN
Abstract

Purpose: Previous literature has demonstrated the mediating role of adiposity in the association between cardiorespiratory fitness (CRF) and cardiometabolic risk as well as the potential role of CRF in attenuating the adverse consequences associated with excess weight. This study aimed to evaluate the mediating role of CRF and adiposity in the possible association with cardiometabolic risk. Method: Observational 3-year longitudinal study that included 420 children and adolescents (10.50 [2.05] y of age at baseline; 56.2% girls). Body mass index (BMI) was calculated, and CRF was evaluated using field assessments. A clustered cardiometabolic risk score (cMetS) was calculated from glucose, systolic blood pressure, total cholesterol/high-density lipoprotein cholesterol ratio, and triglycerides z scores. Analyses evaluated the mediating role of BMI in the association between CRF and cMetS as well as whether CRF mediated the association between BMI and cMetS. Results: BMI at baseline was directly associated with the cMetS at follow-up (0.102; 95% confidence interval, 0.020 to 0.181), independently of CRF, whereas CRF was only indirectly associated with cMetS at follow-up through BMI (−0.036; 95% confidence interval, −0.070 to −0.009), meaning that the association between CRF and cMetS was explained via the mediation role of BMI. Conclusions: BMI presented direct association with cMetS, whereas CRF exhibited indirect association with cMetS mediated via BMI. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effects of resistance training interventions on physical literacy components in children and adolescents: A Systematic Review with Meta-Analysis

Author

Valle Muñoz, Víctor Manuel, primary, Araujo, Romina Saucedo, additional, Brand, Caroline, additional, Martins, Clarice, additional, Henrique, Rafael dos Santos, additional, Gaya, Anelise Reis, additional, López Gil, José Francisco, additional, Faigenbaum, Avery, additional, Barranco Ruiz, Yaira, additional, and Villa González, Emilio, additional

Published
2024
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26. Motivos para a participação nas aulas de educação física segundo adolescentes do ensino fundamental/Reasons for participation in physical education classes according to adolescents of the elementary school/Razones para participación en clases de educación física según adolescentes de la escuela primaria

Author

Lemes, Vanilson Batista, Silva, Naildo Santos, Gaya, Adroaldo Cezar Araujo, Dias, Arieli Fernandes, Brand, Caroline, da Silva, Juliana Oliveira, and Gaya, Anelise Reis

Published
2022
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31. Reliability, reproducibility, and feasibility of youth activity profile (YAP) questionnaire in Chilean children and adolescents.

Author

Brand, Caroline, Zurita-Corvalán, Natalia, Batista Lemes, Vanilson, Villa-González, Emilio, Aguilar-Farías, Nicolas, and Rodríguez-Rodríguez, Fernando

Subjects
*CROSS-sectional method, *SELF-evaluation, *RESEARCH funding, *CRONBACH'S alpha, *RESEARCH methodology evaluation, *SEDENTARY lifestyles, *QUESTIONNAIRES, *CHILEANS, *RESEARCH methodology, *STATISTICAL reliability, *PHYSICAL activity, *EVALUATION, *ADOLESCENCE, *CHILDREN, RESEARCH evaluation
Abstract

This study aimed to evaluate the reliability, reproducibility, and feasibility of the Youth Activity Profile Questionnaire (YAP-SL) in the Chilean version (YAP-C) in a sample of children and adolescents. This cross-sectional study included 160 youth, 59 children (5–11 years old), and 101 adolescents (12–17 years old) from the city of Viña del Mar (Chile). The YAP-SL is a 15-item self-report instrument which was administered twice at an interval of 7 days apart. This questionnaire was designed to capture physical activity (PA) and sedentary behaviour in youths in the last week, categorizing them into three domains: PA at school, PA out-of-school, and sedentary habits. Cronbach's α coefficients were calculated to evaluate the internal consistency (reliability), and the reproducibility was determined by test-retest and Kendall's tau b coefficients. Concerning the total YAP-C score, results indicated moderate-to-high reliability in the total sample (0.71), boys (0.76) and girls (0.66), as well as for children (0.73) and adolescents (0.70). The results also revealed variations in reliability and reproducibility across the three domains. In conclusion, the YAP-SL questionnaire presents moderate-to-high reliability in Chilean children and adolescents. However, the reliability and consistency of the YAP varied across the domains. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Evaluation of IMproving Palliative care Education and Training Using Simulation in Dementia (IMPETUS-D) a staff simulation training intervention to improve palliative care of people with advanced dementia living in nursing homes: a cluster randomised controlled trial

Author

Tropea, Joanne, Nestel, Debra, Johnson, Christina, Hayes, Barbara J., Hutchinson, Anastasia F., Brand, Caroline, Le, Brian H., Blackberry, Irene, Caplan, Gideon A., Bicknell, Ross, Hepworth, Graham, and Lim, Wen K.

Published
2022
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36. Theoretical Approaches for Effective Sustainable Urban Food Policymaking

Author

Debru, Julie, Brand, Caroline, Armendáriz, Vanessa, With contrib. by, Armenia, Stefano, With contrib. by, Atzori, Alberto Stanislao, With contrib. by, Cohen, Nevin, With contrib. by, James, Paul, With contrib. by, Aubry, Christine, Series Editor, Duchemin, Éric, Series Editor, Nasr, Joe, Series Editor, Brand, Caroline, editor, Bricas, Nicolas, editor, Conaré, Damien, editor, Daviron, Benoit, editor, Debru, Julie, editor, Michel, Laura, editor, and Soulard, Christophe-Toussaint, editor

Published
2019
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39. Promoting active behaviours in schoolchildren using the socio- ecological model in the physical education class: study protocol of ACTIBESE Project

Author

Rodríguez-Rodríguez, Fernando, primary, Cristi-Montero, Carlos, additional, Zurita-Corvalán, Natalia, additional, Brand, Caroline, additional, Mota, Jorge, additional, Chillón, Palma, additional, Gaya, Anelise Reis, additional, Brazo-Sayavera, Javier, additional, and Aguilar-Farias, Nicolás, additional

Published
2024
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45. Study protocol and rationale of “the UP project”: evaluating the effectiveness of active breaks on health indicators in desk-based workers

Author

Cristi-Montero, Carlos, primary, Martínez-Flores, Ricardo, additional, Espinoza-Puelles, Juan Pablo, additional, Favero-Ramirez, Laura, additional, Zurita-Corvalan, Natalia, additional, Cañete, Ignacio Castillo, additional, Leppe, Jaime, additional, Ferrari, Gerson, additional, Sadarangani, Kabir P., additional, Cancino-López, Jorge, additional, Hernandez-Jaña, Sam, additional, Farias, Tuillang Yuing, additional, Lemes, Vanilson Batista, additional, Rodríguez-Rodríguez, Fernando, additional, and Brand, Caroline, additional

Published
2024
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46. The Acute Effect of Two Physical Exercise Programs on Cognitive Performance in Schoolchildren

Author

Moraes, Marcos, primary, Brand, Caroline, additional, Silveira, João Francisco Castro, additional, Barbian, Cheila Daiana, additional, Sisnande, Fernando Zaluar, additional, Henriquez-Maquehue, Fernanda, additional, Milagres, Gabriele Zawacki, additional, Cristi-Montero, Carlos, additional, Corbellini, Valeriano Antonio, additional, and Campos, Deivis, additional

Published
2024
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48. Sleep duration and screen time in children and adolescents: Simultaneous moderation role in the relationship between waist circumference and cardiometabolic risk according to physical activity

Author

Sehn, Ana Paula, primary, Brand, Caroline, additional, Tornquist, Luciana, additional, Tornquist, Debora, additional, Silveira, João Francisco de Castro, additional, Gaya, Anelise Reis, additional, Cristi‐Montero, Carlos, additional, Burns, Ryan Donald, additional, Renner, Jane Dagmar Pollo, additional, and Reuter, Cézane Priscila, additional

Published
2024
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