1,860 results on '"Branco, M."'
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2. Comparing fingers and gestures for bci control using an optimized classical machine learning decoder
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Keller, D., Vansteensel, M. J., Mehrkanoon, S., and Branco, M. P.
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Quantitative Biology - Neurons and Cognition - Abstract
Severe impairment of the central motor network can result in loss of motor function, clinically recognized as Locked-in Syndrome. Advances in Brain-Computer Interfaces offer a promising avenue for partially restoring compromised communicative abilities by decoding different types of hand movements from the sensorimotor cortex. In this study, we collected ECoG recordings from 8 epilepsy patients and compared the decodability of individual finger flexion and hand gestures with the resting state, as a proxy for a one-dimensional brain-click. The results show that all individual finger flexion and hand gestures are equally decodable across multiple models and subjects (>98.0\%). In particular, hand movements, involving index finger flexion, emerged as promising candidates for brain-clicks. When decoding among multiple hand movements, finger flexion appears to outperform hand gestures (96.2\% and 92.5\% respectively) and exhibit greater robustness against misclassification errors when all hand movements are included. These findings highlight that optimized classical machine learning models with feature engineering are viable decoder designs for communication-assistive systems., Comment: 6 pages, 4 figures
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- 2024
3. HMX3 is a critical vulnerability in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia: ACUTE MYELOID LEUKEMIA
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Arza-Apalategi, Saioa, Heuts, Branco M. H., Bergevoet, Saskia M., Meering, Roos, Gilissen, Daan, Jansen, Pascal W. T. C., Krippner-Heidenreich, Anja, Valk, Peter J. M., Vermeulen, Michiel, Heidenreich, Olaf, Haferlach, Torsten, Jansen, Joop H., Martens, Joost H. A., and van der Reijden, Bert A.
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- 2024
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4. Impact of the COVID-19 pandemic on antidepressant consumption in the Central region of Portugal: interrupted time series
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Negrão, Luciana G., Coelho, Catarina, Castel-Branco , M. Margarida, Figueiredo, Isabel V., and Fernandez-Llimos, Fernando
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- 2024
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5. Discrepancies among equations to estimate the glomerular filtration rate for drug dosing decision making in aged patients: a cross sectional study
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Castel-Branco, M. Margarida, Lavrador, Marta, Cabral, Ana C., Pinheiro, Adriana, Fernandes, Joana, Figueiredo, Isabel Vitória, and Fernandez-Llimos, Fernando
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- 2024
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6. Multidimensional Evaluation of Production Systems Design Based on Design-for-eXcellence Methodologies
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Branco, M. I., Almeida, A. H., Soares, A. L., Baptista, A. J., Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Wang, Yi-Chi, editor, Chan, Siu Hang, editor, and Wang, Zih-Huei, editor
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- 2024
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7. ESTUDO (AUTO)BIOGRÁFICO SARTRIANO: MÉTODO SOCIOLÓGICO COMPREENSIVO DE PERSPECTIVA SÓCIO-HISTÓRICA E DIALÉTICA
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BRANCO, M. R. D., primary
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- 2024
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8. INTERCULTURALIDADE, JUSTIÇA E IGUALDADE NAS RELAÇÕES EDUCACIONAIS, SOCIAIS E ÉTNICO-RACIAIS
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BRANCO, M. R. D., primary
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- 2024
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9. Numerical semigroups with concentration two
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Rosales, José C., Branco, M. B., and Traesel, Márcio A.
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Mathematics - Commutative Algebra ,20M14 (Primary) 11D07 - Abstract
We define the concentration of a numerical semigroup $S$ as $\mathsf{C}(S)=\max \left\{\text{next}_S(s)-s ~|~ s\in S \backslash \{0\}\right\}$ wherein $\text{next}_S(s)=\min\left\{x \in S ~|~ s
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- 2021
10. High expression of an intragenic long noncoding RNA misinterpreted as high FTO oncogene expression in NPM1 mutant acute myeloid leukemia
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Arza-Apalategi, Saioa, Heuts, Branco M. H., Dooijes, Meike T. M., Gilissen, Daan, van der Heijden, Adrian J. P., Jansen, Joop H., Martens, Joost H. A., and van der Reijden, Bert A.
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- 2023
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11. Understanding blood development and leukemia using sequencing-based technologies and human cell systems
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Branco M. H. Heuts and Joost H. A. Martens
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transcription factors ,eRNA ,gene regulatory networks ,single-cell sequencing ,iPSC ,functional genomics ,Biology (General) ,QH301-705.5 - Abstract
Our current understanding of human hematopoiesis has undergone significant transformation throughout the years, challenging conventional views. The evolution of high-throughput technologies has enabled the accumulation of diverse data types, offering new avenues for investigating key regulatory processes in blood cell production and disease. In this review, we will explore the opportunities presented by these advancements for unraveling the molecular mechanisms underlying normal and abnormal hematopoiesis. Specifically, we will focus on the importance of enhancer-associated regulatory networks and highlight the crucial role of enhancer-derived transcription regulation. Additionally, we will discuss the unprecedented power of single-cell methods and the progression in using in vitro human blood differentiation system, in particular induced pluripotent stem cell models, in dissecting hematopoietic processes. Furthermore, we will explore the potential of ever more nuanced patient profiling to allow precision medicine approaches. Ultimately, we advocate for a multiparameter, regulatory network-based approach for providing a more holistic understanding of normal hematopoiesis and blood disorders.
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- 2023
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12. The set of numerical semigroups of a given multiplicity and Frobenius number
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Branco, M. B., Ojeda, I., and Rosales, J. C.
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Mathematics - Group Theory ,20M14, 11D07 - Abstract
We study the structure of the family of numerical semigroups with fixed multiplicity and Frobenius number. We give an algorithmic method to compute all the semigroups in this family. As an application we compute the set of all numerical semigroups with given multiplicity and genus.
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- 2019
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13. Effectiveness of Intra-Arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma: Relevance of a Multidisciplinary Setting
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Castela G, Providência J, Monteiro M, Oliveiros B, Silva S, Brito M, Machado E, Neto Murta J, Castelo-Branco M, and Correa Z
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retinoblastoma ,intra-arterial chemotherapy ,ocular oncology ,pediatric oncology ,Ophthalmology ,RE1-994 - Abstract
Guilherme Castela,1– 3 Joana Providência,1,2 Madalena Monteiro,1 Bárbara Oliveiros,2 Sónia Silva,4 Manuel Brito,4 Egídio Machado,5 Joaquim Neto Murta,1,2 Miguel Castelo-Branco,2,3,* Zélia Correa6,* 1Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 2Faculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal; 3Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Coimbra, Portugal; 4Department of Pediatric Oncology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 5Department of Medical Imaging, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 6University of Miami, Bascom Palmer Eye Institute, Miami, FL, USA*These authors contributed equally to this workCorrespondence: Guilherme Castela, Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Praceta Prof Mota Pinto, Coimbra, 3004-561, Portugal, Tel +351919702206, Email gcastela@hotmail.comPurpose: We aim to report about effectiveness and safety in the context of our centers’ setting in the management of retinoblastoma with intra-arterial chemotherapy (IAC) in a 5-year retrospective analysis of the Portuguese population.Patients and Methods: Retrospective analysis of consecutive cases of retinoblastoma selected to initiate IAC between 2015 and 2020, at the Portuguese National Reference Center. All included patients underwent complete ophthalmological evaluation under anesthesia with fundus photography. Diagnosis and classification of retinoblastoma was made according to the International Classification of Intraocular Retinoblastoma (ICRB). The patients were further divided into two groups: Group I for primary IAC and Group II for secondary IAC. Tumor recurrence or relapses, systemic metastasis and deaths were documented. Main efficacy outcome included ocular salvage and recurrence-free survival rates estimated using the Kaplan–Meier method.Results: Twenty-eight eyes (19 eyes included in Group I and 9 eyes included in Group II) were eligible and a total of 130 IAC procedures were performed, with a median number of sessions of 4 (range 1– 8) for each treated eye, during a median follow-up of 21 months (range 4– 64). Of the included eyes, 22 (78.6%) were preserved. An overall survival of 100% was achieved. Considering the preserved eyes, the overall median decimal visual acuity achieved at the last visit was 0.15 (range 0.02– 0.8). Three patients had permanent adverse events related to IAC (cataract, vitreous hemorrhage and choroidal ischemia). Considering the survival analysis of recurrence, the mean survival without recurrence was 84.2% for Group I and 66.7% for Group II, and the mean survival without enucleation was 78.6% (no events in Group II).Conclusion: IAC has been shown to be an effective and safe treatment for children with intraocular retinoblastoma. This study demonstrates that IAC is effective even in moderate sample sizes, when a multidisciplinary approach is available.Keywords: retinoblastoma, intra-arterial chemotherapy, ocular oncology, pediatric oncology
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- 2023
14. Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+ CD1c+ CD5− CD163+ conventional type 2 dendritic cells
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Harry Dolstra, Gosse J Adema, Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Joost H A Martens, and Willemijn Hobo
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Adjuvants are key for effective vaccination against cancer and chronic infectious diseases. Saponin-based adjuvants (SBAs) are unique among adjuvants in their ability to induce robust cell-mediated immune responses in addition to antibody responses. Recent preclinical studies revealed that SBAs induced cross-presentation and lipid bodies in otherwise poorly cross-presenting CD11b+ murine dendritic cells (DCs).Method Here, we investigated the response of human DC subsets to SBAs with RNA sequencing and pathway analyses, lipid body induction visualized by laser scanning microscopy, antigen translocation to the cytosol, and antigen cross-presentation to CD8+ T cells.Results RNA sequencing of SBA-treated conventional type 1 DC (cDC1) and type 2 DC (cDC2) subsets uncovered that SBAs upregulated lipid-related pathways in CD11c+ CD1c+ cDC2s, especially in the CD5− CD163+ CD14+ cDC2 subset. Moreover, SBAs induced lipid bodies and enhanced endosomal antigen translocation into the cytosol in this particular cDC2 subset. Finally, SBAs enhanced cross-presentation only in cDC2s, which requires the CD163+ CD14+ cDC2 subset.Conclusions These data thus identify the CD163+ CD14+ cDC2 subset as the main SBA-responsive DC subset in humans and imply new strategies to optimize the application of saponin-based adjuvants in a potent cancer vaccine.
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- 2023
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15. Almost symmetric numerical semigroups with given Frobenius number and type
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Branco, M. B., Ojeda, I., and Rosales, J. C.
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Mathematics - Commutative Algebra ,20M14, 11D07 - Abstract
We give two algorithmic procedures to compute the whole set of almost symmetric numerical semigroups with fixed Frobenius number and type, and the whole set of almost symmetric numerical semigroups with fixed Frobenius number. Our algorithms allow to compute the whole set of almost symmetric numerical semigroups with fixed Frobenius number with similar or even higher efficiency that the known ones. They have been implemented in the GAP (http://www.gap-system.org) package NumericalSgps (http://www.gap-system.org/Packages/numericalsgps.html)., Comment: 12 pages, 1 figure. References updated. A conjecture added (Remark 20). Accepted for publication in Journal of Algebra and its Applications
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- 2018
16. Treatment of Advanced Retinoblastoma in Children Evacuated from Low-Income Countries: Experience from a National Referral Center in Portugal
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Castela G, Providência J, Monteiro M, Silva S, Brito M, Murta JN, Correa Z, and Castelo Branco M
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retinoblastoma ,low income countries ,treatment of advanced disease. ,Ophthalmology ,RE1-994 - Abstract
Guilherme Castela,1,2 Joana Providência,1,2 Madalena Monteiro,1 Sónia Silva,3 Manuel Brito,3 Joaquim Neto Murta,1,2 Zélia Correa,4 Miguel Castelo Branco2 1Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 2Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 3Department of Pediatric Oncology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 4Bascon Palmer Eye Institute, Miami, FL, USACorrespondence: Guilherme CastelaDepartment of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Avenida Dias da Silva 164, Coimbra, 3000, PortugalEmail gcastela@hotmail.comObjective: The aim of our study was to characterize the evacuated African patients diagnosed with retinoblastoma and referred to the Portuguese national referral center (Centro Hospital e Universitário de Coimbra, University of Coimbra), identifying inequalities in the stage of diagnosis and prognostic results.Design: Retrospective observational study of evacuated African patients diagnosed with retinoblastoma and referred to the Portuguese National Referral Center (Centro Hospital e Universitário de Coimbra, University of Coimbra).Results: The study included 15 patients between October 2015 and October 2020 from Angola, Cape Verde, Guinea-Bissau and São Tomé and Príncipe. Seven (46.7%) children presented bilateral retinoblastoma. The median age at the time of diagnosis was 20.9 (interquartile range, 16– 41) months. The presenting symptoms were leukocoria (86.7%), strabism (53.3%) and buphthalmus (40%). In terms of tumor staging, five (33.3%) children presented with extraocular retinoblastoma and 10 (66.7%) children presented with intraocular retinoblastoma. At presentation, no pineal involvement was diagnosed but two (13.3%) children presented with central nervous system involvement at the time of the first observation. Children were treated with enucleation, exenteration, systemic chemotherapy, intra-arterial chemotherapy and/or supportive palliative care. During the follow-up period (mean 27.2 ± 18.2 months), the overall survival was 73.3%.Conclusion: A small proportion of African children are being referred to our center, when considering the expected incidence of retinoblastoma in these countries, and referred children arrive at advanced stages of the disease, compromising treatment outcomes. Considering retinoblastoma is now a curable disease, national and international interventions are required to attempt a better management of children born in low-income countries.Keywords: retinoblastoma, low income countries, treatment of advanced disease
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- 2021
17. Numerical semigroups closed under addition of their divisors
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Rosales, J. C. and Branco, M. B.
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- 2021
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18. ENSINO REMOTO E INCLUSÃO DE ALUNOS SURDOS NA EDUCAÇÃO SUPERIOR
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SILVA, N. O., primary, BRANCO, M. A. C., additional, and CHAHINI, Thelma Helena Costa, additional
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- 2022
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19. Dense numerical semigroups
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Rosales, J. C., Branco, M. B., and Faria, M. C.
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- 2021
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20. Association between anticholinergic burden and anticholinergic adverse outcomes in the elderly: Pharmacological basis of their predictive value for adverse outcomes
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Lavrador, Marta, Castel-Branco, M. Margarida, Cabral, Ana C., Veríssimo, Manuel T., Figueiredo, Isabel V., and Fernandez-Llimos, Fernando
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- 2021
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21. Interpretation of the acceleration obtained by an Inertial Measurement Unit (IMU) in countermovement jump, in Athletics' elite athletes
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Miranda-Oliveira, P., primary, Serra, P., additional, Branco, M., additional, and Fernandes, O., additional
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- 2021
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22. Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation
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Branco M. H. Heuts, Saioa Arza-Apalategi, Sinne G. Alkema, Esther Tijchon, Laura Jussen, Saskia M. Bergevoet, Bert A. van der Reijden, and Joost H. A. Martens
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MLL-AF9 ,induced pluripotent stem cells (iPSCs) ,hematopoiesis ,myeloid ,differentiation ,bioinformatics ,Cytology ,QH573-671 - Abstract
A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we generated a human inducible pluripotent stem cell (hiPSC) model with a doxycycline dose-dependent MLL-AF9 expression. We exploited MLL-AF9 expression as an oncogenic hit to uncover epigenetic and transcriptomic effects on iPSC-derived hematopoietic development and the transformation into (pre-)leukemic states. In doing so, we observed a disruption in early myelomonocytic development. Accordingly, we identified gene profiles that were consistent with primary MLL-AF9 AML and uncovered high-confidence MLL-AF9-associated core genes that are faithfully represented in primary MLL-AF9 AML, including known and presently unknown factors. Using single-cell RNA-sequencing, we identified an increase of CD34 expressing early hematopoietic progenitor-like cell states as well as granulocyte-monocyte progenitor-like cells upon MLL-AF9 activation. Our system allows for careful chemically controlled and stepwise in vitro hiPSC-derived differentiation under serum-free and feeder-free conditions. For a disease that currently lacks effective precision medicine, our system provides a novel entry-point into exploring potential novel targets for personalized therapeutic strategies.
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- 2023
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23. Frobenius R-Variety of the Numerical Semigroups Contained in a Given One
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Rosales, J. C., Branco, M. B., and Traesel, M. A.
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- 2022
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24. Size of the associations between anticholinergic burden tool scores and adverse outcomes in older patients
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Lavrador, Marta, Cabral, Ana C., Figueiredo, Isabel V., Veríssimo, Manuel T., Castel-Branco, M. Margarida, and Fernandez-Llimos, Fernando
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- 2021
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25. Brain and behaviour phenotyping of a mouse model of neurofibromatosis type‐1: an MRI/DTI study on social cognition
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Petrella, LI, Cai, Y, Sereno, JV, Gonçalves, SI, Silva, AJ, and Castelo‐Branco, M
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Biological Sciences ,Biomedical and Clinical Sciences ,Neurosciences ,Genetics ,Neurofibromatosis ,Behavioral and Social Science ,Rare Diseases ,Biomedical Imaging ,Basic Behavioral and Social Science ,Brain Disorders ,Neurological ,Mental health ,Animals ,Behavior ,Animal ,Brain ,Cognition ,Cognition Disorders ,Diffusion Tensor Imaging ,Disease Models ,Animal ,Female ,Magnetic Resonance Imaging ,Male ,Mice ,Mice ,Inbred C57BL ,Neurofibromatosis 1 ,Phenotype ,Prefrontal Cortex ,Social Behavior ,Social Behavior Disorders ,Structure-Activity Relationship ,magnetic resonance imaging ,mice ,neurofibromatosis type-1 ,social cognition ,spatial learning ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Neurofibromatosis type-1 (NF1) is a common neurogenetic disorder and an important cause of intellectual disability. Brain-behaviour associations can be examined in vivo using morphometric magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) to study brain structure. Here, we studied structural and behavioural phenotypes in heterozygous Nf1 mice (Nf1(+/-) ) using T2-weighted imaging MRI and DTI, with a focus on social recognition deficits. We found that Nf1(+/-) mice have larger volumes than wild-type (WT) mice in regions of interest involved in social cognition, the prefrontal cortex (PFC) and the caudate-putamen (CPu). Higher diffusivity was found across a distributed network of cortical and subcortical brain regions, within and beyond these regions. Significant differences were observed for the social recognition test. Most importantly, significant structure-function correlations were identified concerning social recognition performance and PFC volumes in Nf1(+/-) mice. Analyses of spatial learning corroborated the previously known deficits in the mutant mice, as corroborated by platform crossings, training quadrant time and average proximity measures. Moreover, linear discriminant analysis of spatial performance identified 2 separate sub-groups in Nf1(+/-) mice. A significant correlation between quadrant time and CPu volumes was found specifically for the sub-group of Nf1(+/-) mice with lower spatial learning performance, suggesting additional evidence for reorganization of this region. We found strong evidence that social and spatial cognition deficits can be associated with PFC/CPu structural changes and reorganization in NF1.
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- 2016
26. Phenotypic antimicrobial susceptibility of environmental bacteria from mastitic milk of pastured dairy cows of S. Miguel (Azores)
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Simões, João, Branco, M., Andrade, J., and Müller, A.
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- 2020
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27. The Hot and Energetic Universe: The X-ray Integral Field Unit (X-IFU) for Athena+
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Barret, D., Herder, J. W. den, Piro, L., Ravera, L., Hartog, R. Den, Macculi, C., Barcons, X., Page, M., Paltani, S., Rauw, G., Wilms, J., Ceballos, M., Duband, L., Gottardi, L., Lotti, S., de Plaa, J., Pointecouteau, E., Schmid, C., Akamatsu, H., Bagliani, D., Bandler, S., Barbera, M., Bastia, P., Biasotti, M., Branco, M., Camon, A., Cara, C., Cobo, B., Colasanti, L., Costa-Kramer, J. L., Corcione, L., Doriese, W., Duval, J. M., Fabrega, L., Gatti, F., de Gerone, M., Guttridge, P., Kelley, R., Kilbourne, C., van der Kuur, J., Mineo, T., Mitsuda, K., Natalucci, L., Ohashi, T., Peille, P., Perinati, E., Pigot, C., Pizzigoni, G., Pobes, C., Porter, F., Renotte, E., Sauvageot, J. L., Sciortino, S., Torrioli, G., Valenziano, L., Willingale, D., de Vries, C., and van Weers, H.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Athena+ mission concept is designed to implement the Hot and Energetic Universe science theme submitted to the European Space Agency in response to the call for White Papers for the definition of the L2 and L3 missions of its science program. The Athena+ science payload consists of a large aperture high angular resolution X-ray optics and twelve meters away, two interchangeable focal plane instruments: the X-ray Integral Field Unit (X-IFU) and the Wide Field Imager (WFI). The X-IFU is a cryogenic X-ray spectrometer, based on a large array of Transition Edge Sensors (TES), offering 2.5 eV spectral resolution, with ~5" pixels, over a field of view of 5 arc minutes in diameter. In this paper, we briefly describe the Athena+ mission concept and the X-IFU performance requirements. We then present the X-IFU detector and readout electronics principles, the current design of the focal plane assembly, the cooling chain and review the global architecture design. Finally, we describe the current performance estimates, in terms of effective area, particle background rejection, count rate capability and velocity measurements. Finally, we emphasize on the latest technology developments concerning TES array fabrication, spectral resolution and readout performance achieved to show that significant progresses are being accomplished towards the demanding X-IFU requirements., Comment: Supporting paper for the science theme "The Hot and Energetic Universe" to be implemented by the Athena+ X-ray observatory (http://www.the-athena-x-ray-observatory.eu). 17 pages, 19 figures
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- 2013
28. Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)
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Chincarini, A., Peira, E., Morbelli, S., Pardini, M., Bauckneht, M., Arbizu, J., Castelo-Branco, M., Büsing, K.A., de Mendonça, A., Didic, M., Dottorini, M., Engelborghs, S., Ferrarese, C., Frisoni, G.B., Garibotto, V., Guedj, E., Hausner, L., Hugon, J., Verhaeghe, J., Mecocci, P., Musarra, M., Queneau, M., Riverol, M., Santana, I., Guerra, U.P., and Nobili, F.
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- 2019
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29. Qualification and test of space compatible superconducting current leads (REBCO) designed for adiabatic demagnetization refrigerators.
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Duval, J M, Prouvé, T, Collier-Wright, M, Drechsler, A, Hindley, D, La Rosa Betancourt, M, Kroll, R, Branco, M, Orgaz Diaz, D, and Schlachter, S I
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- 2024
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30. Discrepancies among equations to estimate the glomerular filtration rate for drug dosing decision making in aged patients: a cross sectional study
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Castel-Branco, M. Margarida, primary, Lavrador, Marta, additional, Cabral, Ana C., additional, Pinheiro, Adriana, additional, Fernandes, Joana, additional, Figueiredo, Isabel Vitória, additional, and Fernandez-Llimos, Fernando, additional
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- 2023
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31. The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia
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Arza-Apalategi, Saioa, primary, Heuts, Branco M. H., additional, Bergevoet, Saskia M., additional, Meering, Roos, additional, Gilissen, Daan, additional, Jansen, Pascal W. T. C., additional, Krippner-Heidenreich, Anja, additional, Valk, Peter J. M., additional, Vermeulen, Michiel, additional, Heidenreich, Olaf, additional, Haferlach, Torsten, additional, Jansen, Joop H., additional, Martens, Joost H. A., additional, and van der Reijden, Bert A., additional
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- 2023
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32. Global molecular calcium score: is there a link between sodium fluoride uptake and cardiovascular risk burden?
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Borges-Rosa, J, primary, Oliveira-Santos, M, additional, Silva, R, additional, Gomes, A, additional, Campos, G O, additional, Gomes, A R, additional, Abrunhosa, A, additional, Castelo-Branco, M, additional, Goncalves, L, additional, and Ferreira, M J, additional
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- 2023
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33. Increased aortic valve uptake of sodium fluoride is associated with higher cardiovascular risk: assessing pathophysiology with PET/CT
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Borges-Rosa, J, primary, Oliveira-Santos, M, additional, Silva, R, additional, Gomes, A, additional, Campos, G O, additional, Gomes, A R, additional, Abrunhosa, A, additional, Castelo-Branco, M, additional, Goncalves, L, additional, and Ferreira, M J, additional
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- 2023
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34. Understanding blood development and leukemia using sequencing-based technologies and human cell systems
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Heuts, Branco M. H., primary and Martens, Joost H. A., additional
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- 2023
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35. Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics
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The ATLAS Collaboration, Aad, G., Abat, E., Abbott, B., Abdallah, J., Abdelalim, A. A., Abdesselam, A., Abdinov, O., Abi, B., Abolins, M., Abramowicz, H., Acharya, B. S., Adams, D. L., Addy, T. N., Adorisio, C., Adragna, P., Adye, T., Aguilar-Saavedra, J. A., Aharrouche, M., Ahlen, S. P., Ahles, F., Ahmad, A., Ahmed, H., Aielli, G., Akdogan, T., Akesson, T. P. A., Akimoto, G., Alam, M. S., Alam, M. A., Albert, J., Albrand, S., Aleksa, M., Aleksandrov, I. N., Alessandria, F., Alexa, C., Alexander, G., Alexandre, G., Alexopoulos, T., Alhroob, M., Alimonti, G., Alison, J., Aliyev, M., Allport, P. P., Allwood-Spiers, S. E., Aloisio, A., Alon, R., Alonso, A., Alonso, J., Alviggi, M. G., Amako, K., Amaral, P., Amelung, C., Ammosov, V. V., Amorim, A., Amoros, G., Amram, N., Anastopoulos, C., Anders, C. F., Anderson, K. J., Andreazza, A., Andrei, V., Andrieux, M-L., Anduaga, X. S., Anghinolfi, F., Antonaki, A., Antonelli, M., Antonelli, S., Antunovic, B., Anulli, F. A., Arabidze, G., Aracena, I., Arai, Y., Arce, A. T. H., Archambault, J. P., Arfaoui, S., Arguin, J-F., Argyropoulos, T., Arik, E., Arik, M., Armbruster, A. J., Arnaez, O., Arnault, C., Artamonov, A., Arutinov, D., Asai, M., Asai, S., Ask, S., Asman, B., Asner, D., Asquith, L., Assamagan, K., Astbury, A., Astvatsatourov, A., Atkinson, T., Atoian, G., Auerbach, B., Auge, E., Augsten, K., Aurousseau, M. A., Austin, N., Avolio, G., Avramidou, R., Axen, A., Ay, C., Azuelos, G., Azuma, Y., Baak, M. A., Baccaglioni, G., Bacci, C., Bachacou, H., Bachas, K., Backes, M., Badescu, E., Bagnaia, P., Bai, Y., Bailey, D. C., Baines, J. T., Baker, O. K., Pedrosa, F. Baltasar Dos Santos, Banas, E., Banerjee, S., Banfi, D., Bangert, A., Bansal, V., Baranov, S. P., Baranov, S., Barashkou, A., Barber, T. B., Barberio, E. L., Barberis, D., Barbero, M. B., Bardin, D. Y., Barillari, T., Barisonzi, M., Barklow, T., Barlow, N. B., Barnett, B. M., Barnett, R. M., Baron, S., Baroncelli, A., Barr, A. J., Barreiro, F., da Costa, J. Barreiro Guimaraes, Barrillon, P., Bartoldus, R., Bartsch, D., Bastos, J., Bates, R. L., Batley, J. R., Battaglia, A., Battistin, M., Bauer, F., Bazalova, M., Beare, B., Beauchemin, P. H., Beccherle, R. B., Becerici, N., Bechtle, P., Beck, G. A., Beck, H. P., Beckingham, M., Becks, K. H., Bedajanek, I., Beddall, A. J., Beddall, A., Bednar, P., Bednyakov, V. A., Bee, C., Harpaz, S. Behar, Behera, P. K., Beimforde, M., Belanger-Champagne, C., Bell, P. J., Bell, W. H., Bella, G., Bellagamba, L., Bellina, F., Bellomo, M., Belloni, A., Belotskiy, K., Beltramello, O., Ami, S. Ben, Benary, O., Benchekroun, D., Bendel, M., Benedict, B. H., Benekos, N., Benhammou, Y., Benincasa, G. P., Benjamin, D. P., Benoit, M., Bensinger, J. R., Benslama, K., Bentvelsen, S., Beretta, M., Berge, D., Kuutmann, E. Bergeaas, Berger, N., Berghaus, F., Berglund, E., Beringer, J., Bernardet, K., Bernat, P., Bernhard, R., Bernius, C., Berry, T., Bertin, A., Besson, N., Bethke, S., Bianchi, R. M., Bianco, M., Biebel, O., Biesiada, J., Biglietti, M., Bilokon, H., Binet, S., Bingul, A., Bini, C., Biscarat, C., Bischofberger, M., Bitenc, U., Black, K. M., Blair, R. E., Blanchot, G., Blocker, C., Blocki, J., Blondel, A., Blum, W., Blumenschein, U., Boaretto, C., Bobbink, G. J., Bocci, A., Bodine, B., Boek, J., Boelaert, N., Boeser, S., Bogaerts, J. A., Bogouch, A., Bohm, C., Bohm, J., Boisvert, V., Bold, T., Boldea, V., Bondarenko, V. G., Bondioli, M., Boonekamp, M., Booth, C. N., Booth, P. S. L., Booth, J. R. A., Borisov, A., Borissov, G., Borjanovic, I., Borroni, S., Bos, K., Boscherini, D., Bosman, M., Bosteels, M., Boterenbrood, H., Bouchami, J., Boudreau, J., Bouhova-Thacker, E. V., Boulahouache, C., Bourdarios, C., Boyd, J., Boyko, I. R., Braem, A., Branchini, P., Brandenburg, G. W., Brandt, A., Brandt, O., Bratzler, U., Brau, J. E., Braun, H. M., Brelier, B., Bremer, J., Brenner, R., Bressler, S., Breton, D., Brett, N. D., Britton, D., Brochu, F. M., Brock, I., Brock, R., Brodet, E., Broggi, F., Brooijmans, G., Brooks, W. K., Brubaker, E., de Renstrom, P. A. Bruckman, Bruncko, D., Bruneliere, R., Brunet, S., Bruni, A., Bruni, G., Bruschi, M., Buanes, T., Bucci, F. B., Buchholz, P., Buckley, A. G., Budagov, I. A., Buescher, V., Bugge, L., Bujor, F., Bulekov, O., Bunse, M., Buran, T., Burckhart, H., Burdin, S., Burke, S., Busato, E., Buszello, C. P., Butin, F., Butler, B., Butler, J. M., Buttar, C. M., Butterworth, J. M., Byatt, T., Urban, S. Cabrera, Caforio, D., Cakir, O., Calafiura, P., Calderini, G., Calkins, R., Caloba, L. P., Caloi, R., Calvet, D., Camarri, P., Cambiaghi, M., Cameron, D., Segura, F. Campabadal, Campana, S., Campanelli, M., Canale, V., Cantero, J., Garrido, M. D. M. Capeans, Caprini, I., Caprini, M., Capua, M., Caputo, R., Caramarcu, C., Cardarelli, R., Carli, T., Carlino, G., Carminati, L., Caron, B., Caron, S., Montero, S. Carron, Carter, A. A., Carter, J. R., Carvalho, J., Casadei, D., Casado, M. P., Cascella, M., Caso, C., Hernadez, A. M. Castaneda, Miranda, E. Castaneda, Gimenez, V. Castillo, Castro, N. F., Cataldi, G., Catinaccio, A., Catmore, J. R., Cattai, A., Cattani, G., Caughron, S., Cauz, D., Cavalleri, P., Cavalli, D., Cavalli-Sforza, M., Cavasinni, V., Cazzato, A., Ceradini, F., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cetin, S. A., Cevenini, F., Chafaq, A. C., Chakraborty, D., Chapman, J. D., Chapman, J. W., Chareyre, E. C., Charlton, D. G., Chatterjii, S. C., Cheatham, S., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, H., Chen, T., Chen, X., Cheng, S., Cheng, T. L., Cheplakov, A., Chepurnov, V. F., Moursli, R. Cherkaoui El, Tcherniatine, V., Chesneanu, D., Cheu, E., Cheung, S. L., Chevalier, L., Chevallier, F., Chiarella, V., Chiefari, G., Chikovani, L., Childers, J. T., Chilingarov, A., Chiodini, G., Chouridou, S., Chren, D., Christidi, I. A., Christov, A., Chromek-Burckhart, D., Chu, M. L., Chudoba, J., Ciapetti, G., Ciftci, A. K., Ciftci, R., Cindro, V., Ciobotaru, M. D., Ciocca, C., Ciocio, A., Cirilli, M., Citterio, M., Clark, A., Cleland, W., Clemens, J. C., Clement, B., Clement, C., Clements, D., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coelli, S., Coggeshall, J., Cogneras, E., Cojocaru, C. D., Colas, J., Cole, B., Colijn, A. P., Collard, C., Collins, N. J., Collins-Tooth, C., Collot, J., Colon, G., Coluccia, R., Muino, P. Conde, Coniavitis, E., Consonni, M., Constantinescu, S., Conta, C., Conventi, F., Cook, J., Cooke, M., Cooper, B. D., Cooper-Smith, N. J., Copic, K., Cornelissen, T., Corradi, M., Corriveau, F. C., Corso-Radu, A., Cortes-Gonzalez, A., Costa, G., Costa, M. J., Costanzo, D., Costin, T., Cote, D., Torres, R. Coura, Courneyea, L., Cowan, G., Cowden, C. C., Cox, B. E., Cranmer, K., Cranshaw, J., Cristinziani, M., Crosetti, G., Crupi, R. C., Crepe-Renaudin, S., Cuciuc, C. -M., Almenar, C. Cuenca, Curatolo, M., Curtis, C. J., Cwetanski, P., Czyczula, Z., D'Auria, S., D'Onofrio, M., D'Orazio, A., Mello, A. Da Rocha Gesualdi, Da Silva, P. V. M., Da Via, C. V., Dabrowski, W., Dai, T., Dallapiccola, C., Dallison, S. J., Daly, C. H., Dam, M., Danielsson, H. O., Dannheim, D., Dao, V., Darbo, G., Davey, W. D., Davidek, T., Davidson, N., Davidson, R., Davison, A. R., Dawson, I., Dawson, J. W., Daya, R. K., De, K., de Asmundis, R., De Castro, S., Salgado, P. E. De Castro Faria, De Cecco, S., De Groot, N., de Jong, P., De La Cruz-Burelo, E., De La Taille, C., De Mora, L., Branco, M. De Oliveira, De Pedis, D., De Salvo, A., De Sanctis, U., De Santo, A., De Regie, J. B. De Vivie, De Zorzi, G., Dean, S., Dedes, G., Dedovich, D. V., Defay, P. O., Degenhardt, J., Dehchar, M., Del Papa, C., Del Peso, J., Del Prete, T., Dell'Acqua, A., Dell'Asta, L., Della Pietra, M., della Volpe, D., Delmastro, M., Delruelle, N., Delsart, P. A., Demers, S., Demichev, M., Demirkoz, B., Deng, W., Denisov, S. P., Dennis, C., Derue, F., Dervan, P., Desch, K. K., Deviveiros, P. O., Dewhurst, A., Dhullipudi, R., Di Ciaccio, A., Di Ciaccio, L., Di Domenico, A., Di Girolamo, A., Di Girolamo, B., Di Luise, S., Di Mattia, A., Di Nardo, R., Di Simone, A., Di Sipio, R., Diaz, M. A., Diehl, E. B., Dietrich, J., Diglio, S., Yagci, K. Dindar, Dingfelder, D. J., Dionisi, C., Dita, P., Dita, S., Dittus, F., Djama, F., Djilkibaev, R., Djobava, T., Vale, M. A. B. do, Dobbs, M., Dobinson, R., Dobos, D., Dobson, E., Dobson, M., Dogan, O. B., Doherty, T., Doi, Y., Dolejsi, J., Dolenc, I., Dolezal, Z., Dolgoshein, B. A., Donega, M., Donini, J., Donszelmann, T., Dopke, J., Dorfan, D. E., Doria, A., Anjos, A. Dos, Dosil, M., Dotti, A., Dova, M. T., Doxiadis, A., Doyle, A. T., Dragic, J. D., Drasal, Z., Dressnandt, N., Driouichi, C., Dris, M., Dubbert, J., Duchovni, E., Duckeck, G., Dudarev, A., Duehrssen, M., Duerdoth, I. P., Duflot, L., Dufour, M-A., Dunford, M., Duperrin, A., Yildiz, H. Duran, Dushkin, A., Duxfield, R., Dwuznik, M., Dueren, M., Ebenstein, W. L., Eckert, S., Eckweiler, S., Edmonds, K., Eerola, P., Egorov, K., Ehrenfeld, W., Ehrich, T., Eifert, T., Eigen, G., Einsweiler, K., Eisenhandler, E., Ekelof, T., Kacimi, M. El, Ellert, M., Elles, S., Ellis, K., Ellis, N., Elmsheuser, J., Elsing, M., Ely, R., Emeliyanov, D., Engelmann, R., Engl, A., Epp, B., Eppig, A., Epshteyn, V. S., Erdmann, J., Ereditato, A., Eriksson, D., Ermoline, I., Ernst, J., Ernst, E., Ernwein, J., Errede, D., Errede, S., Escalier, M., Escobar, C., Curull, X. Espinal, Esposito, B., Etienne, F., Etienvre, A. I., Etzion, E., Evans, H., Fabbri, L., Fabre, C., Faccioli, P., Facius, K., Fakhrutdinov, R. M., Falciano, S., Falou, A. C., Fang, Y., Fanti, M., Farbin, A., Farilla, A., Farley, J., Farooque, T., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Fatholahzadeh, B., Fayard, L., Fayette, F., Febbraro, R., Federic, P., Fedin, O. L., Fedorko, I., Feligioni, L., Feng, C., Feng, E. J., Fenyuk, A. B., Ferencei, J., Ferland, J., Fernando, W., Ferrag, S., Ferrari, A., Ferrari, P., Ferrari, R., Ferrer, A., Ferrer, M. L., Ferrere, D., Ferretti, C., Fiascaris, M., Fiedler, F., Filipcic, A., Filippas, A., Filthaut, F., Fincke-Keeler, M., Fiorini, L., Firan, A., Fischer, G., Fisher, M. J., Flacher, H. F., Flechl, M., Fleck, I., Fleckner, J., Fleischmann, P., Fleischmann, S., Corral, C. M. Fleta, Flick, T., Castillo, L. R. Flores, Flowerdew, M. J., Foehlisch, F., Fokitis, M., Martin, T. Fonseca, Forbush, D. A., Formica, A., Forti, A., Foster, J. M., Fournier, D., Foussat, A., Fowler, A. J., Fowler, K. F., Fox, H., Francavilla, P., Franchino, S., Francis, D., Franz, S., Fraternali, M., Fratina, S., Freestone, J., Froeschl, R., Froidevaux, D., Frost, J. A., Fukunaga, C., Torregrosa, E. Fullana, Fuster, J., Gabaldon, C., Gabizon, O. G., Gadfort, T., Gadomski, S., Gagliardi, G., Gagnon, P., Gallas, E. J., Gallas, M. V., Gallop, B. J., Galyaev, E., Gan, K. K., Gao, Y. S., Gaponenko, A., Garcia-Sciveres, M., Garcia, C., Navarro, J. E. Garcia, Gardner, R. W., Garelli, N., Garitaonandia, H., Garonne, V. G., Gatti, C., Gaudio, G., Gaumer, O., Gauzzi, P., Gavrilenko, I. L., Gay, C., Gaycken, G. G., Gayde, J-C., Gazis, E. N., Gee, C. N. P., Geich-Gimbel, Ch., Gellerstedt, K., Gemme, C., Genest, M. H., Gentile, S., Georgatos, F., George, S., Gerlach, P., Geweniger, C., Ghazlane, H., Ghez, P., Ghodbane, N., Giacobbe, B., Giagu, S., Giangiobbe, V., Gianotti, F., Gibbard, B., Gibson, A., Gibson, S. M., Gilbert, L. M., Gilchriese, M., Gilewsky, V., Gillman, A. R., Gingrich, D. M., Ginzburg, J., Giokaris, N., Giordani, M. P., Giovannini, P., Giraud, P. F., Girtler, P., Giugni, D., Giusti, P., Gjelsten, B. K., Gladilin, L. K., Glasman, C., Glazov, A., Glitza, K. W., Glonti, G. L., Gnanvo, K. G., Godfrey, J. G., Godlewski, J., Goepfert, T., Goessling, C., Goettfert, T., Goggi, V. G., Goldfarb, S., Goldin, D., Golling, T., Gollub, N. P., Gomes, A., Goncalo, R., Gong, C., de la Hoz, S. Gonzalez, Silva, M. L. Gonzalez, Gonzalez-Sevilla, S., Goodson, J. J., Goossens, L., Gorbounov, P. A., Gordon, H., Gorelov, I., Gorfine, G., Gorini, B., Gorini, E., Gorisek, A., Gornicki, E., Gorokhov, S. A., Goryachev, S. V., Goryachev, V. N., Gosdzik, B., Gosselink, M., Gostkin, M. I., Eschrich, I. Gough, Gouighri, M., Goujdami, D., Goulette, M., Goussiou, A. G., Gowdy, S., Goy, C., Grabowska-Bold, I., Grafstroem, P., Grahn, K-J., Cardoso, L. Granado, Grancagnolo, F., Grancagnolo, S., Gratchev, V., Gray, H. M., Gray, J. A., Graziani, E., Green, B., Greenwood, Z. D., Gregor, I. M., Griesmayer, E., Grigalashvili, N., Grillo, A. A., Grimm, K., Grishkevich, Y. V., Groer, L. S., Grognuz, J., Groh, M., Groll, M., Gross, E., Grosse-Knetter, J., Groth-Jensen, J., Gruse, C., Grybel, K., Guarino, V. J., Guicheney, C., Guida, A. G., Guillemin, T., Gunther, J., Guo, B., Gupta, A., Gusakov, Y., Gutierrez, P., Guttman, N. G., Gutzwiller, O., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haas, A., Haas, S., Haber, C., Hackenburg, R., Hadavand, H. K., Hadley, D. R., Haertel, R., Hajduk, Z., Hakobyan, H., Hakobyan, R. H., Haller, J., Hamacher, K., Hamilton, A., Han, H., Han, L., Hanagaki, K., Hance, M., Handel, C., Hanke, P., Hansen, J. R., Hansen, J. B., Hansen, J. D., Hansen, P. H., Hansl-Kozanecka, T., Hansson, P., Hara, K., Hare, G. A., Harenberg, T., Harrington, R. D., Harris, O. B., Harris, O. M., Hart, J. C., Hartert, J., Hartjes, F., Haruyama, T., Harvey, A., Hasegawa, S., Hasegawa, Y., Hashemi, K., Hassani, S., Hatch, M., Haug, F., Haug, S., Hauschild, M., Hauser, R., Havranek, M., Hawkings, R. J., Hawkins, D., Hayakawa, T., Hayward, H. S., Haywood, S. J., He, M., Head, S. J., Hedberg, V., Heelan, L., Heinemann, B., Heinemann, F. E. W., Heldmann, M., Hellman, S., Helsens, C., Henderson, R. C. W., Henke, M., Correia, A. M. Henriques, Henrot-Versille, S., Henss, T., Hershenhorn, A. D., Herten, G., Hertenberger, R., Hervas, L., Hessey, N. P., Hidvegi, A., Higon-Rodriguez, E., Hill, D., Hill, J. C., Hiller, K. H., Hillier, S. J., Hinchliffe, I., Hinkelbein, C., Hirsch, F., Hobbs, J., Hod, N. H., Hodgkinson, M. C., Hodgson, P., Hoecker, A., Hoeferkamp, M. R., Hoffman, J., Hoffmann, D., Hohlfeld, M. H., Holmgren, S. O., Holy, T., Homma, Y., Homola, P., Horazdovsky, T., Hori, T., Horn, C., Horner, S., Horvat, S., Hostachy, J-Y., Hou, S., Houlden, M. A., Hoummada, A., Hrivnac, J., Hruska, I., Hryn'ova, T., Hsu, P. J., Huang, G. S., Huang, J., Hubacek, Z., Hubaut, F., Huegging, F., Hughes, E. W., Hughes, G., Hughes-Jones, R. E., Hurst, P., Hurwitz, M., Huse, T., Huseynov, N., Huston, J., Huth, J., Iacobucci, G., Ibbotson, M., Ibragimov, I., Ichimiya, R., Iconomidou-Fayard, L., Idarraga, J., Iengo, P., Igonkina, O., Ikegami, Y., Ikeno, M., Ilchenko, Y., Iliadis, D. I., Ilyushenka, Y., Imori, M., Ince, T., Ioannou, P., Iodice, M., Ishikawa, A., Ishino, M., Ishizawa, Y., Ishmukhametov, R., Isobe, T., Issakov, V., Issever, C., Istin, S., Ivashin, A. V., Iwanski, W., Iwasaki, H., Izen, J. M., Izzo, V., Jackson, J. N., Jaekel, M., Jahoda, M., Jain, V., Jakobs, K., Jakubek, J., Jana, D., Jansen, E., Jantsch, A., Jared, R. C., Jarlskog, G., Jarron, P., Jelen, K., Plante, I. Jen-La, Jenni, P., Jez, P., Jezequel, S., Ji, W., Jia, J., Jiang, Y., Jin, G., Jin, S., Jinnouchi, O., Joffe, D., Johansen, L. G., Johansen, M., Johansson, K. E., Johansson, P., Johns, K. A., Jon-And, K., Jones, A., Jones, G., Jones, R. W. L., Jones, T. W., Jones, T. J., Jonsson, O., Joos, D., Joram, C., Jorge, P. M., Jorgensen, S., Jovanovic, P., Juranek, V., Jussel, P., Kabachenko, V. V., Kabana, S., Kaci, M., Kaczmarska, A., Kado, M., Kagan, H., Kagan, M., Kaiser, S., Kajomovitz, E., Kalinovskaya, L. V., Kalinowski, A., Kama, S., Kanaya, N., Kaneda, M., Kantserov, V. A., Kanzaki, J., Kaplan, B., Kapliy, A., Kaplon, J., Karagounis, M., Unel, M. Karagoz, Karr, K., Kartvelishvili, V., Karyukhin, A. N., Kashif, L., Kasmi, A., Kass, R. D., Kataoka, M., Kataoka, Y., Katsoufis, E., Katzy, J., Kawagoe, K., Kawamoto, T., Kayl, M. S., Kayumov, F., Kazanin, V. A., Kazarinov, M. Y., Kazi, S. I., Keates, J. R., Keeler, R., Keener, P. T., Kehoe, R., Keil, M., Kekelidze, G. D., Kelly, M., Kennedy, J., Kenyon, M., Kepka, O., Kerschen, N., Kersevan, B. P., Kersten, S., Khakzad, M., Khalilzade, F., Khandanyan, H., Khanov, A., Kharchenko, D., Khodinov, A., Kholodenko, A. G., Khomich, A., Khoriauli, G., Khovanskiy, N., Khovanskiy, V., Khramov, E., Khubua, J., Kilvington, G., Kim, H., Kim, M. S., Kim, S. H., Kind, O., Kind, P., King, B. T., Kirk, J., Kirsch, G. P., Kirsch, L. E., Kiryunin, A. E., Kisielewska, D., Kittelmann, T., Kiyamura, H., Kladiva, E., Klaiber-Lodewigs, J., Klein, M., Klein, U., Kleinknecht, K., Klier, A., Klimentov, A., Klingenberg, R., Klinkby, E. B., Klioutchnikova, T., Klok, P. F., Klous, S., Kluge, E. -E., Kluge, T., Kluit, P., Klute, M., Kluth, S., Knecht, N. S., Kneringer, E., Ko, B. R., Kobayashi, T., Kobel, M., Koblitz, B., Kocnar, A., Kodys, P., Koeneke, K., Koenig, A. C., Koenig, S., Koepke, L., Koetsveld, F., Koevesarki, P., Koffas, T., Koffeman, E., Kohout, Z., Kohriki, T., Kokott, T., Kolanoski, H., Kolesnikov, V., Koletsou, I., Kollefrath, M., Kolos, S., Kolya, S. D., Komar, A. A., Komaragiri, J. R., Kondo, T., Kono, T., Kononov, A. I., Konoplich, R., Konovalov, S. P., Konstantinidis, N., Kootz, A., Koperny, S., Korcyl, K., Kordas, K., Koreshev, V., Korn, A., Korolkov, I., Korotkov, V. A., Kortner, O., Kostyukhin, V. V., Kotamaki, M. J., Kotov, S., Kotov, V. M., Kotov, K. Y., Koupilova, Z., Kourkoumelis, C., Koutsman, A., Kovar, S., Kowalewski, R., Kowalski, H., Kowalski, T. Z., Kozanecki, W., Kozhin, A. S., Kral, V., Kramarenko, V. A., Kramberger, G., Krasny, M. W., Krasznahorkay, A., Kreisel, A. K., Krejci, F., Krepouri, A., Krieger, P., Krobath, G., Kroeninger, K., Kroha, H., Kroll, J., Krstic, J., Kruchonak, U., Krueger, H., Krumshteyn, Z. V., Kubota, T., Kuehn, S. K., Kugel, A., Kuhl, T., Kuhn, D., Kukhtin, V., Kulchitsky, Y., Kuleshov, S., Kummer, C. K., Kuna, M., Kupco, A., Kurashige, H., Kurata, M. K., Kurchaninov, L. L., Kurochkin, Y. A., Kus, V., Kuykendall, W., Kuznetsova, E. K., Kvasnicka, O., Kwee, R., La Rosa, M., La Rotonda, L., Labarga, L., Labbe, J. 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T., Todorova-Nova, S., Tojo, J., Tokar, S., Tokushuku, K., Tomasek, L., Tomasek, M., Tomasz, F., Tomoto, M., Tompkins, D., Tompkins, L., Toms, K., Tonazzo, A., Tong, G., Tonoyan, A., Topfel, C., Topilin, N. D., Torrence, E., Pastor, E. Torro, Toth, J., Touchard, F., Tovey, D. R., Tovey, S. N., Trefzger, T., Tremblet, L., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Tripiana, M. F., Triplett, N., Trischuk, W., Trivedi, A., Trocme, B., Troncon, C., Tsarouchas, C., Tseng, J. C-L., Tsiafis, I., Tsiakiris, M., Tsiareshka, P. V., Tsipolitis, G., Tskhadadze, E. G., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Turala, M., Turecek, D., Cakir, I. Turk, Turlay, E., Tuts, P. M., Twomey, M. S., Tyndel, M., Typaldos, D., Tzanakos, G., Ueda, I., Uhrmacher, M., Ukegawa, F., Unal, G., Underwood, D. G., Undrus, A., Unel, G., Unno, Y., Urkovsky, E., Urquijo, P., Urrejola, P., Usai, G., Vacavant, L., Vacek, V., Vachon, B., Vahsen, S., Valderanis, C., Valenta, J., Valente, P., Valkar, S., Ferrer, J. A. Valls, Van der Bij, H., van der Graaf, H., van der Kraaij, E., van der Poel, E., van Eldik, N., van Gemmeren, P., van Kesteren, Z., van Vulpen, I., VanBerg, R., Vandelli, W., Vandoni, G., Vaniachine, A., Vankov, P., Vannucci, F., Rodriguez, F. Varela, Vari, R., Varnes, E. W., Varouchas, D., Vartapetian, A., Varvell, K. E., Vassilakopoulos, V. I., Vassilieva, L., Vataga, E., Vazeille, F., Vegni, G., Veillet, J. J., Vellidis, C., Veloso, F., Veness, R., Veneziano, S., Ventura, A., Ventura, D., Ventura, S., Venturi, N., Vercesi, V., Verducci, M., Verkerke, W., Vermeulen, J. C., Vetterli, M. C., Vichou, I., Vickey, T., Viehhauser, G. H. A., Villa, M., Villani, E. G., Perez, M. Villaplana, Vilucchi, E., Vincter, M. G., Vinogradov, V. B., Virchaux, M., Viret, S., Virzi, J., Vitale, A., Vitells, O. V., Vivarelli, I., Vives, R., Vaques, F. Vives, Vlachos, S., Vlasak, M., Vlasov, N., Vogt, H., Vokac, P., Volpi, M., Volpini, G., von der Schmitt, H., von Loeben, J., von Toerne, E., Vorobel, V., Vorobiev, A. P., Vorwerk, V., Vos, M., Voss, R., Voss, T. T., Vossebeld, J. H., Vranjes, N., Vrba, V., Vreeswijk, M., Anh, T. Vu, Vudragovic, M., Vuillermet, R., Vukotic, I., Wagner, P., Wahlen, H., Walbersloh, J., Walder, J., Walker, R., Walkowiak, W., Wall, R., Wang, C., Wang, J., Wang, J. C., Wang, S. M. W., Ward, C. P., Warsinsky, M., Watkins, P. M., Watson, A. T., Watts, G., Watts, S. W., Waugh, A. T., Waugh, B. M., Webel, M., Weber, J., Weber, M., Weber, M. S., Weber, P., Weidberg, A. R., Weingarten, J., Weiser, C., Wellenstein, H., Wells, P. S., Wen, M., Wenaus, T., Wendler, S., Wengler, T., Wenig, S., Wermes, N., Werner, M., Werner, P., Werthenbach, U., Wessels, M., Wheeler-Ellis, S. J., Whitaker, S. P., White, A., White, M. J., White, S., Whiteson, D., Whittington, D., Wicek, F., Wicke, D., Wickens, F. J., Wiedenmann, W., Wielers, M., Wienemann, P., Wiglesworth, C., Wildauer, A., Wildt, M. A., Wilhelm, I., Wilkens, H. G., Williams, H. H., Willis, W., Willocq, S., Wilson, J. A., Wilson, M. G., Wilson, A., Wingerter-Seez, I., Winklmeier, F. W., Winton, L., Wittgen, M., Wolter, M. W., Wolters, H., Wosiek, B., Wotschack, J., Woudstra, M. J., Wraight, K., Wright, C., Wrona, B., Wu, S. L., Wu, X., Xella, S., Xie, S., Xie, Y., Xu, G., Xu, N., Yamamoto, A., Yamamoto, S., Yamamura, T., Yamanaka, K., Yamazaki, T., Yamazaki, Y., Yan, Z., Yang, H., Yang, U. K., Yang, Y., Yang, Z., Yao, W-M., Yao, Y., Yasu, Y., Ye, J., Ye, S., Yilmaz, M., Yoosoofmiya, R., Yorita, K., Yoshida, R., Young, C., Youssef, S. P., Yu, D., Yu, J., Yu, M., Yu, X., Yuan, J., Yuan, L., Yurkewicz, A., Zaidan, R., Zaitsev, A. M., Zajacova, Z., Zanello, L., Zarzhitsky, P., Zaytsev, A., Zdrazil, M., Zeitnitz, C., Zeller, M., Zema, P. F., Zendler, C., Zenin, A. V., Zenis, T., Zenonos, Z., Zenz, S., Zerwas, D., Zhan, Z., Zhang, H., Zhang, J., Zhang, Q., Zheng, W., Zhang, X., Zhao, L., Zhao, T., Zhao, Z., Zhelezko, A., Zhemchugov, A., Zheng, S., Zhong, J., Zhou, B., Zhou, N., Zhou, S., Zhou, Y., Zhu, C. G., Zhu, H., Zhu, Y., Zhuang, X. A., Zhuravlov, V., Zilka, B., Zimmermann, R., Zimmermann, S., Zinna, M., Ziolkowski, M., Zitoun, R., Zivkovic, L., Zmouchko, V. V., Zobernig, G., Zoccoli, A., Nedden, M. zur, and Zychacek, V.
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High Energy Physics - Experiment - Abstract
A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN.
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- 2008
36. Almost-Positioned Numerical Semigroups
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Branco, M. B., Faria, M. C., and Rosales, J. C.
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- 2021
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37. Patients’ clinical information requirements to apply the STOPP/START criteria
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Carvalho, Rosário, Lavrador, Marta, Cabral, Ana C., Veríssimo, Manuel T., Figueiredo, Isabel V., Fernandez-Llimos, Fernando, and Castel-Branco, M. Margarida
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- 2019
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38. Consequences of ignoring patient diagnoses when using the 2015 Updated Beers Criteria
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Lavrador, Marta, Silva, Alice A., Cabral, Ana C., Caramona, M. Margarida, Fernandez-Llimos, Fernando, Figueiredo, Isabel V., and Castel-Branco, M. Margarida
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- 2019
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39. Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
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Bussy, A., Levy, J., Best, T., Patel, R., Cupo, L., Van Langenhove, T., Nielsen, J., Pijnenburg, Y., Waldö, M., Remes, A., Schroeter, M., Santana, I., Pasquier, F., Otto, M., Danek, A., Levin, J., Le Ber, I., Vandenberghe, R., Synofzik, M., Moreno, F., de Mendonça, A., Sanchez‐Valle, R., Laforce, R., Langheinrich, T., Gerhard, A., Graff, C., Butler, C., Sorbi, S., Jiskoot, L., Seelaar, H., van Swieten, J., Finger, E., Tartaglia, M., Masellis, M., Tiraboschi, P., Galimberti, D., Borroni, B., Rowe, J., Bocchetta, M., Rohrer, J., Devenyi, G., Chakravarty, M., Ducharme, S., Esteve, A., Nelson, A., Bouzigues, A., Heller, C., Greaves, C., Cash, D., Thomas, D., Todd, E., Benotmane, H., Zetterberg, H., Swift, I., Nicholas, J., Samra, K., Russell, L., Shafei, R., Convery, R., Timberlake, C., Cope, T., Rittman, T., Benussi, A., Premi, E., Gasparotti, R., Archetti, S., Gazzina, S., Cantoni, V., Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Borracci, V., Rossi, G., Giaccone, G., Di Fede, G., Caroppo, P., Prioni, S., Redaelli, V., Tang‐Wai, D., Rogaeva, E., Castelo‐Branco, M., Freedman, M., Keren, R., Black, S., Mitchell, S., Shoesmith, C., Bartha, R., Rademakers, R., Poos, J., Papma, J., Giannini, L., van Minkelen, R., Nacmias, B., Ferrari, C., Polito, C., Lombardi, G., Bessi, V., Veldsman, M., Andersson, C., Thonberg, H., Öijerstedt, L., Jelic, V., Thompson, P., Lladó, A., Antonell, A., Olives, J., Balasa, M., Bargalló, N., Borrego‐Ecija, S., Verdelho, A., Maruta, C., Ferreira, C., Miltenberger, G., do Couto, F., Gabilondo, A., Gorostidi, A., Villanua, J., Cañada, M., Tainta, M., Zulaica, M., Barandiaran, M., Alves, P., Bender, B., Wilke, C., Graf, L., Vogels, A., Vandenbulcke, M., Van Damme, P., Bruffaerts, R., Poesen, K., Rosa‐Neto, P., Gauthier, S., Camuzat, A., Brice, A., Bertrand, A., Funkiewiez, A., Rinaldi, D., Saracino, D., Colliot, O., Sayah, S., Prix, C., Wlasich, E., Wagemann, O., Loosli, S., Schönecker, S., Hoegen, T., Lombardi, J., Anderl‐Straub, S., Rollin, A., Kuchcinski, G., Bertoux, M., Lebouvier, T., Deramecourt, V., Santiago, B., Duro, D., Leitão, M., Almeida, M., Tábuas‐Pereira, M., Afonso, S., Engel, A., Polyakova, M., Erasmus MC other, Neurology, Radiology & Nuclear Medicine, Clinical Genetics, GENetic Frontotemporal dementia Initiative (GENFI), Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Engel, Annerose, Polyakova, Maryna, Esteve, Aitana Sogorb, Nelson, Annabel, Bouzigues, Arabella, Heller, Carolin, Greaves, Caroline V, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Zetterberg, Henrik, Swift, Imogen J, Nicholas, Jennifer, Samra, Kiran, Russell, Lucy L, Bocchetta, Martina, Shafei, Rachelle, Convery, Rhian S, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Bussy, Aurélie [0000-0001-6695-9941], Nielsen, Jørgen E [0000-0003-0453-5582], Borroni, Barbara [0000-0001-9340-9814], Bocchetta, Martina [0000-0003-1814-5024], Devenyi, Gabriel A [0000-0002-7766-1187], Apollo - University of Cambridge Repository, and Amsterdam Neuroscience - Neurodegeneration
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C9orf72 Protein ,Radiological and Ultrasound Technology ,Medizin ,frontotemporal dementia ,Neurology ,Frontotemporal Dementia ,Cerebellum ,Humans ,magnetic resonance imaging ,genetics ,neuropsychiatry ,Radiology, Nuclear Medicine and imaging ,Human medicine ,ddc:610 ,Neurology (clinical) ,Atrophy ,Anatomy ,genetics [Frontotemporal Dementia] ,genetics [C9orf72 Protein] - Abstract
Funder: Alzheimer Society of Canada; Id: http://dx.doi.org/10.13039/501100000143, Funder: Weston Brain Institute; Id: http://dx.doi.org/10.13039/100012479, Funder: Fonds de Recherche du Québec ‐ Santé, Funder: Canadian Institutes of Health Research; Id: http://dx.doi.org/10.13039/501100000024, Funder: NIHR Rare Diseases Translational Research Collaboration, Funder: Deutsche Forschungsgemeinschaft; Id: http://dx.doi.org/10.13039/501100001659, Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.
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- 2023
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40. Effect of 6-month community-based exercise interventions on gait and functional fitness of an older population: a quasi-experimental study
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Ramalho F, Santos-Rocha R, Branco M, Moniz-Pereira V, André HI, Veloso AP, and Carnide F
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Geriatrics ,RC952-954.6 - Abstract
Fátima Ramalho,1,2 Rita Santos-Rocha,1,2 Marco Branco,1,2 Vera Moniz-Pereira,2 Helô-Isa André,2 António P Veloso,2 Filomena Carnide2 1Sport Sciences School of Rio Maior (ESDRM), Polytechnic Institute of Santarém, Rio Maior, Portugal; 2Laboratory of Biomechanics and Functional Morphology, Interdisciplinary Centre for the Study of Human Performance (CIPER), Faculty of Human Kinetics (FMH), University of Lisbon, Cruz Quebrada, Portugal Background: Gait ability in older adults has been associated with independent living, increased survival rates, fall prevention, and quality of life. There are inconsistent findings regarding the effects of exercise interventions in the maintenance of gait parameters.Objectives: The aim of the study was to analyze the effects of a community-based periodized exercise intervention on the improvement of gait parameters and functional fitness in an older adult group compared with a non-periodized program.Methods: A quasi-experimental study with follow-up was performed in a periodized exercise group (N=15) and in a non-periodized exercise group (N=13). The primary outcomes were plantar pressure gait parameters, and the secondary outcomes were physical activity, aerobic endurance, lower limb strength, agility, and balance. These variables were recorded at baseline and after 6 months of intervention.Results: Both programs were tailored to older adults’ functional fitness level and proved to be effective in reducing the age-related decline regarding functional fitness and gait parameters. Gait parameters were sensitive to both the exercise interventions. Conclusion: These exercise protocols can be used by exercise professionals in prescribing community exercise programs, as well as by health professionals in promoting active aging. Keywords: mobility, community exercise programs, active aging, plantar pressure analysis, ground reaction forces, gait properties
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- 2018
41. Development and Test of High-Temperature Superconductor Harness for Cryogenic Instruments on Satellites
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Schlachter, S. I., primary, Bagrets, N., additional, Branco, M. B. C., additional, Collier-Wright, M., additional, Dherbecourt, D., additional, Drechsler, A., additional, Duval, J.-M., additional, Erbe, M., additional, Fink, S., additional, Genswein, K., additional, Hindley, D., additional, Holzapfel, B., additional, Jung, A., additional, Kroll, R., additional, Betancourt, M. La Rosa, additional, Nast, R., additional, Diaz, D. Orgaz, additional, Prouve, T., additional, and Ringsdorf, B., additional
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- 2023
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42. Saponin-based adjuvants enhance antigen cross-presentation in human CD11c+CD1c+CD5−CD163+conventional type 2 dendritic cells
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Ho, Nataschja I, primary, Huis in 't Veld, Lisa G M, additional, van Eck van der Sluijs, Jesper, additional, Heuts, Branco M H, additional, Looman, Maaike W G, additional, Kers-Rebel, Esther D, additional, van den Dries, Koen, additional, Dolstra, Harry, additional, Martens, Joost H A, additional, Hobo, Willemijn, additional, and Adema, Gosse J, additional
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- 2023
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43. Cortical control of vertical and horizontal saccades in progressive supranuclear palsy: An exploratory fMRI study
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Lemos, J, Pereira, D, Almendra, L, Rebelo, D, Patrício, M, Castelhano, J, Cunha, G, Januário, C, Cunha, L, Freire, A, and Castelo-Branco, M
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- 2017
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44. Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia
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Pinto, A.M., Geenen, R., Wager, T.D., Lumley, M.A., Häuser, W., Kosek, E., Ablin, J.N., Amris, K., Branco, J., Buskila, D., Castelhano, J., Castelo-Branco, M., Crofford, L.J., Fitzcharles, M-A., López-Solà, M., Luís, M., Marques, T.R., Mease, P.J., Palavra, F., Rhudy, J.L., Uddin, L.Q., Castilho, P., Jacobs, J.W.G., da Silva, J.A.P., Trauma and Grief, Leerstoel Boelen, Clinical Psychology (onderzoeksprogramma), Trauma and Grief, Leerstoel Boelen, and Clinical Psychology (onderzoeksprogramma)
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Rheumatology - Abstract
Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances and other symptoms, and has a substantial socioeconomic impact. Current biomedical and psychosocial treatments are unsatisfactory for many patients, and treatment progress has been hindered by the lack of a clear understanding of the pathogenesis of fibromyalgia. We present here a model of fibromyalgia that integrates current psychosocial and neurophysiological observations. We propose that an imbalance in emotion regulation, reflected by an overactive 'threat' system and underactive 'soothing' system, might keep the 'salience network' (also known as the midcingulo-insular network) in continuous alert mode, and this hyperactivation, in conjunction with other mechanisms, contributes to fibromyalgia. This proposed integrative model, which we term the Fibromyalgia: Imbalance of Threat and Soothing Systems (FITSS) model, should be viewed as a working hypothesis with limited supporting evidence available. We hope, however, that this model will shed new light on existing psychosocial and biological observations, and inspire future research to address the many gaps in our knowledge about fibromyalgia, ultimately stimulating the development of novel therapeutic interventions.
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- 2022
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45. Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales
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Samra, K, MacDougall, AM, Peakman, G, Bouzigues, A, Bocchetta, M, Cash, DM, Greaves, CV, Convery, RS, van Swieten, JC, Jiskoot, L, Seelaar, H, Butler, CR, Fenoglio, C, Rohrer, JD, Gerhard, A, Ducharme, S, Le Ber, I, Tiraboschi, P, Santana, I, Pasquier, F, Levin, J, Shoesmith, C, Otto, M, Russell, LL, Nelson, A, Cash, D, Thomas, DL, Todd, E, Ferrari, C, Benotmane, H, Timberlake, C, Gabilondo, A, Cope, T, Rittman, T, Benussi, A, Premi, E, Gasparotti, R, Thompson, P, Archetti, S, Fumagalli, G, do Couto, FS, Borracci, V, Polito, C, Rossi, G, Giaccone, G, Di Fede, G, Caroppo, P, Ferreira, CB, Prioni, S, Langheinrich, T, Redaelli, V, Lladó, A, Bartha, R, Tang-Wai, D, Rogaeva, E, Castelo-Branco, M, Freedman, M, Keren, R, Black, S, Mitchell, S, Miltenberger, G, Rademakers, R, Poos, J, Papma, JM, Giannini, L, van Minkelen, R, Pijnenburg, Y, Gauthier, S, Nacmias, B, Lombardi, G, Bessi, V, Veldsman, M, Andersson, C, Thonberg, H, Öijerstedt, L, Prix, C, Jelic, V, Antonell, A, Graff, C, Olives, J, Balasa, M, Bargalló, N, Borrego-Ecija, S, Verdelho, A, Kuchcinski, G, Maruta, C, Gorostidi, A, Laforce, R, Villanua, J, Wlasich, E, Cañada, M, Tainta, M, Zulaica, M, Barandiaran, M, Moreno, F, Alves, P, Bender, B, Bertoux, M, Wilke, C, Lebouvier, T, Camuzat, A, Graf, L, Vogels, A, Vandenbulcke, M, Van Damme, P, Bruffaerts, R, Poesen, K, Rosa-Neto, P, Sanchez-Valle, R, Brice, A, Bertrand, A, Funkiewiez, A, Rinaldi, D, Saracino, D, Colliot, O, Sorbi, S, Sayah, S, Wagemann, O, Loosli, S, Schönecker, S, Hoegen, T, Lombardi, J, Anderl-Straub, S, Nicholas, J, Rollin, A, Deramecourt, V, Arighi, A, Santiago, B, Duro, D, Leitão, MJ, Almeida, MR, Tábuas-Pereira, M, Gazzina, S, Afonso, S, Masellis, M, Tartaglia, C, Shafei, R, Rowe, JB, Borroni, B, Finger, E, Synofzik, M, Galimberti, D, Vandenberghe, R, de Mendonça, A, Cantoni, V, Genetic FTD Initiative (GENFI), Samra, Kiran [0000-0002-3105-7099], Apollo - University of Cambridge Repository, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Nelson, Annabel, Bocchetta, Martina, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Nicholas, Jennifer, Samra, Kiran, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, and Verdelho, Ana
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Progranulin ,Clinical Neurology ,C9ORF72 ,tau Proteins ,AMYOTROPHIC-LATERAL-SCLEROSIS ,diagnosis [Frontotemporal Dementia] ,C9orf72 ,Tremor ,Genetics ,Humans ,ddc:610 ,genetics [Frontotemporal Dementia] ,genetics [C9orf72 Protein] ,MUTATION ,Science & Technology ,C9orf72 Protein ,HERITABILITY ,Amyotrophic Lateral Sclerosis ,PROGRESSIVE SUPRANUCLEAR PALSY ,COGNITIVE IMPAIRMENT ,REPEAT EXPANSION ,genetics [tau Proteins] ,Motor ,PATHOLOGICAL FEATURES ,Neurology ,FOS: Biological sciences ,Frontotemporal Dementia ,Mutation ,Human medicine ,Neurosciences & Neurology ,Neurology (clinical) ,Tau ,TAU ,Life Sciences & Biomedicine ,Frontotemporal dementia ,PARKINSONISM - Abstract
Funder: CIBERNED, Funder: Canadian Institutes of Health Research; doi: http://dx.doi.org/10.13039/501100000024, Funder: Lemaire Family Foundation, Funder: Swedish Frontotemporal Dementia Initiative, Funder: Italian Ministry of Health, Funder: Weston Brain Institute; doi: http://dx.doi.org/10.13039/100012479, Funder: Mady Browaaeys Fund, Funder: Miriam Marks Brain Research UK, Funder: Bluefield Project, OBJECTIVE: To investigate the optimal method of adding motor features to a clinical rating scale for frontotemporal dementia (FTD). METHODS: Eight hundred and thirty-two participants from the international multicentre Genetic FTD Initiative (GENFI) study were recruited: 522 mutation carriers (with C9orf72, GRN and MAPT mutations) and 310 mutation-negative controls. A standardised clinical questionnaire was used to assess eight motor symptoms (dysarthria, dysphagia, tremor, slowness, weakness, gait disorder, falls and functional difficulties using hands). Frequency and severity of each motor symptom was assessed, and a principal component analysis (PCA) was performed to identify how the different motor symptoms loaded together. Finally, addition of a motor component to the CDR® plus NACC FTLD was investigated (CDR® plus NACC FTLD-M). RESULTS: 24.3% of mutation carriers had motor symptoms (31.7% C9orf72, 18.8% GRN, 19.3% MAPT) compared to 6.8% of controls. Slowness and gait disorder were the commonest in all genetic groups while tremor and falls were the least frequent. Symptom severity scores were similar to equivalent physical motor examination scores. PCA revealed that all motor symptoms loaded together so a single additional motor component was added to the CDR® plus NACC FTLD to form the CDR® plus NACC FTLD-M. Individual global scores were more severe with the CDR® plus NACC FTLD-M, and no patients with a clinically diagnosed motor disorder (ALS/FTD-ALS or parkinsonism) were classified anymore as asymptomatic (unlike the CDR® plus NACC FTLD alone). CONCLUSIONS: Motor features are present in mutation carriers at all disease stages across all three genetic groups. Inclusion of motor symptoms in a rating scale that can be used in future clinical trials will not only ensure a more accurate severity measure is recorded but that a wider spectrum of FTD phenotypes can be included in the same trial.
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- 2022
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46. The Number of Saturated Numerical Semigroups with a Determinate Genus
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Rosales, J. C., Branco, M. B., Torrão, D., Fonseca, Irene, Series editor, Pinto, Alberto Adrego, Series editor, Bourguignon, Jean-Pierre, editor, Jeltsch, Rolf, editor, and Viana, Marcelo, editor
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- 2015
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47. VYGOTSKY E A TEORIA HISTÓRICO-CULTURAL: ANÁLISE DA INCLUSÃO ESCOLAR DE DEFICIENTES INTELECTUAIS
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Maria do Socorro Castelo Branco M. Lima
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Social Sciences ,Regional economics. Space in economics ,HT388 - Abstract
Analisa a inclusão escolar de deficientes intelectuais na perspectiva da Teoria Histórico- Cultural (THC). Defendida por L.S. Vygotski e seus colaboradores, esta teoria baseia-se na lei geral do desenvolvimento cultural, em dois níveis – primeiramente, interpessoal e depois intrapessoal. O pensador bielo-russo, porém, acentua que somente por via das relações sociais carregadas de significações, surge o desenvolvimento das funções psicológicas superiores ou culturais mediadas pelo outro, por meio da linguagem, signo por excelência. Isto é, a essência do desenvolvimento cultural consiste na apropriação e no domínio do social. O objetivo deste artigo é abordar a deficiência intelectual à luz da perspectiva da THC. Foi utilizada, exclusivamente, a pesquisa bibliográfica, sendo os principais autores mencionados Lev Semenovitch Vygotski (1997) e Ana Maria Nurdi Padilha (2014). O texto focaliza quatro tópicos: 1- Mudança da nomenclatura de deficiência mental para deficiência intelectual; 2- Inclusão escolar/exclusão; 3- Teoria Histórico-Cultural; e 4Inclusão de deficientes intelectuais na perspectiva Histórico-Cultural, com vistas a fomentar o debate da inclusão escolar de deficientes intelectuais não apenas como produto de condições orgânicas, contudo, culturais e sociais.
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- 2017
48. Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation
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Heuts, Branco M. H., primary, Arza-Apalategi, Saioa, additional, Alkema, Sinne G., additional, Tijchon, Esther, additional, Jussen, Laura, additional, Bergevoet, Saskia M., additional, van der Reijden, Bert A., additional, and Martens, Joost H. A., additional
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- 2023
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49. N-3 Fatty Acids Supplementation And Chemotherapy Induced Toxicity: Scoping Review
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Mateus, C., primary, Branco, M., additional, Neves, P.M., additional, Branco, T., additional, Capelas, M.L., additional, Makitie, A., additional, Ravasco, P., additional, Mateus, Carlota, additional, Branco, Mariana Garcia, additional, Neves, Pedro Miguel, additional, Santos, Teresa, additional, Capelas, Manuel Luís, additional, Makitie, Antti, additional, and Ravasco, Paula, additional
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- 2023
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50. Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model
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Pinto, A.M., Luís, M., Geenen, R., Palavra, F., Lumley, M.A., Ablin, J.N., Amris, K., Branco, J., Buskila, D., Castelhano, J., Castelo-Branco, M., Crofford, L.J., Fitzcharles, M.-A., Häuser, W., Kosek, E., López-Solà, M., Mease, P., Marques, T.R., Jacobs, J.W.G., Castilho, P., da Silva, J.A.P., Pinto, A.M., Luís, M., Geenen, R., Palavra, F., Lumley, M.A., Ablin, J.N., Amris, K., Branco, J., Buskila, D., Castelhano, J., Castelo-Branco, M., Crofford, L.J., Fitzcharles, M.-A., Häuser, W., Kosek, E., López-Solà, M., Mease, P., Marques, T.R., Jacobs, J.W.G., Castilho, P., and da Silva, J.A.P.
- Abstract
Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to: a) synthesize current knowledge on fibromyalgia; b) explore and highlight multi-level links and pathways between different systems; and c) build bridges connecting disparate perspectives. An extensive panel of international experts in neurophysiological and psychosocial aspects of fibromyalgia discussed the collected evidence and progressively refined and conceptualized its interpretation. This work constitutes an essential step towards the development of a model capable of integrating the main factors implicated in fibromyalgia into a single, unified construct which appears indispensable to foster the understanding, assessment, and intervention for fibromyalgia.
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- 2023
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