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1. Guidelines for best practices in monitoring established coeliac disease in adult patients

Author

Elli, Luca, Leffler, Daniel, Cellier, Christophe, Lebwohl, Benjamin, Ciacci, Carolina, Schumann, Michael, Lundin, Knut E. A., Chetcuti Zammit, Stefania, Sidhu, Reena, Roncoroni, Leda, Bai, Julio C., Lee, Anne R., Dennis, Melinda, Robert, Marie E., Rostami, Kamran, Khater, Sherine, Comino, Isabel, Cebolla, Angel, Branchi, Federica, Verdu, Elena F., Stefanolo, Juan Pablo, Wolf, Randi, Bergman-Golden, Sheba, Trott, Nick, Scudeller, Luigia, Zingone, Fabiana, Scaramella, Lucia, and Sanders, David S.

Published
2024
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3. PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study

Author

Branchi, Federica, Klingenberg-Noftz, Rolf, Friedrich, Kristina, Bürgel, Nataly, Daum, Severin, Buchkremer, Juliane, Sonnenberg, Elena, Schumann, Michael, Treese, Christoph, Tröger, Hanno, Lissner, Donata, Epple, Hans-Jörg, Siegmund, Britta, Stroux, Andrea, Adler, Andreas, Veltzke-Schlieker, Winfried, Autenrieth, Daniel, Leonhardt, Silke, Fischer, Andreas, Jürgensen, Christian, Pape, Ulrich-Frank, Wiedenmann, Bertram, Möschler, Oliver, Schreiner, Maximilian, Strowski, Mathias Z., Hempel, Volkmar, Huber, Yvonne, Neumann, Helmut, and Bojarski, Christian

Published
2022
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8. Low Sensitivity of Simtomax Point of Care Test in Detection of Celiac Disease in a Prospective Multicenter Study

Author

Tangermann, Paul, Branchi, Federica, Itzlinger, Alice, Aschenbeck, Jens, Schubert, Stefan, Maul, Jochen, Liceni, Thomas, Schröder, Andreas, Heller, Frank, Spitz, Wolfgang, Möhler, Ulrich, Graefe, Ulrich, Radke, Michael, Trenkel, Stefan, Schmitt, Markus, Loddenkemper, Christoph, Preiß, Jan C., Ullrich, Reiner, Daum, Severin, Siegmund, Britta, Bojarski, Christian, and Schumann, Michael

Published
2019
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21. Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: A Delphi Consensus Statement of the International CApsule endoscopy REsearch (I-CARE) Group

Author

Elli, Luca, primary, Marinoni, Beatrice, additional, Sidhu, Reena, additional, Bojarski, Christian, additional, Branchi, Federica, additional, Tontini, Gian Eugenio, additional, Chetcuti Zammit, Stefania, additional, Khater, Sherine, additional, Eliakim, Rami, additional, Rondonotti, Emanuele, additional, Saurin, Jean Cristhophe, additional, Bruno, Mauro, additional, Buchkremer, Juliane, additional, Cadoni, Sergio, additional, Cavallaro, Flaminia, additional, Dray, Xavier, additional, Ellul, Pierre, additional, Urien, Ignacio Fernandez, additional, Keuchel, Martin, additional, Kopylov, Uri, additional, Koulaouzidis, Anastasios, additional, Leenhardt, Romain, additional, Baltes, Peter, additional, Beaumont, Hanneke, additional, Marmo, Clelia, additional, McNamara, Deirdre, additional, Mussetto, Alessandro, additional, Nemeth, Artur, additional, Cuadrado Robles, Enrique Perez, additional, Perrod, Guillame, additional, Rahmi, Gabriel, additional, Riccioni, Maria Elena, additional, Robertson, Alexander, additional, Spada, Cristiano, additional, Toth, Ervin, additional, Triantafyllou, Konstantinos, additional, Wurm Johansson, Gabriele, additional, and Rimondi, Alessandro, additional

Published
2022
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24. Results from the German registry for refractory celiac disease

Author

Weber, Marko, additional, Wolf, Nina, additional, Branchi, Federica, additional, Tangermann, Paul, additional, Itzlinger, Alice, additional, Poralla, Lukas, additional, Preiß, Jan C., additional, Grunert, Philip, additional, Daum, Severin, additional, Siegmund, Britta, additional, Stallmach, Andreas, additional, and Schumann, Michael, additional

Published
2021
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25. PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study

Author

Branchi, Federica, primary, Klingenberg-Noftz, Rolf, additional, Friedrich, Kristina, additional, Bürgel, Nataly, additional, Daum, Severin, additional, Buchkremer, Juliane, additional, Sonnenberg, Elena, additional, Schumann, Michael, additional, Treese, Christoph, additional, Tröger, Hanno, additional, Lissner, Donata, additional, Epple, Hans-Jörg, additional, Siegmund, Britta, additional, Stroux, Andrea, additional, Adler, Andreas, additional, Veltzke-Schlieker, Winfried, additional, Autenrieth, Daniel, additional, Leonhardt, Silke, additional, Fischer, Andreas, additional, Jürgensen, Christian, additional, Pape, Ulrich-Frank, additional, Wiedenmann, Bertram, additional, Möschler, Oliver, additional, Schreiner, Maximilian, additional, Strowski, Mathias Z., additional, Hempel, Volkmar, additional, Huber, Yvonne, additional, Neumann, Helmut, additional, and Bojarski, Christian, additional

Published
2021
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26. Leptin Downregulates Angulin-1 in Active Crohn’s Disease via STAT3

Author

Hu, Jia-Chen E., Bojarski, Christian, Branchi, Federica, Fromm, Michael, and Krug, Susanne M.

Subjects
Adult, Male, STAT3 Transcription Factor, Crohn’s disease, Pyridines, Biopsy, tight junction, Down-Regulation, leptin, Article, lcsh:Chemistry, Young Adult, Crohn Disease, Humans, Intestinal Mucosa, lcsh:QH301-705.5, Receptors, Lipoprotein, angulin-1, Middle Aged, Tyrphostins, digestive system diseases, Cyclic S-Oxides, MARVEL Domain Containing 2 Protein, lcsh:Biology (General), lcsh:QD1-999, Case-Control Studies, Female, Caco-2 Cells, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Transcription Factors
Abstract

Crohn&rsquo, s disease (CD) has an altered intestinal barrier function, yet the underlying mechanisms remain to be disclosed. The tricellular tight junction protein tricellulin is involved in the maintenance of the paracellular macromolecule barrier and features an unchanged expression level in CD but a shifted localization. As angulins are known to regulate the localization of tricellulin, we hypothesized the involvement of angulins in CD. Using human biopsies, we found angulin-1 was downregulated in active CD compared with both controls and CD in remission. In T84 and Caco-2 monolayers, leptin, a cytokine secreted by fat tissue and affected in CD, decreased angulin-1 expression. This effect was completely blocked by STAT3 inhibitors, Stattic and WP1066, but only partially by JAK2 inhibitor AG490. The effect of leptin was also seen at a functional level as we observed in Caco-2 cells an increased permeability for FITC-dextran 4 kDa indicating an impaired barrier against macromolecule uptake. In conclusion, we were able to show that in active CD angulin-1 expression is downregulated, which leads to increased macromolecule permeability and is inducible by leptin via STAT3. This suggests that angulin-1 and leptin secretion are potential targets for intervention in CD to restore the impaired intestinal barrier.

Published
2020
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31. Efficacy and safety of device‐assisted enteroscopy ERCP in liver transplantation: A systematic review and meta‐analysis

Author

Ferretti, Francesca, primary, Fraquelli, Mirella, additional, Cantù, Paolo, additional, Penagini, Roberto, additional, Casazza, Giovanni, additional, Vecchi, Maurizio, additional, Orlando, Stefania, additional, Invernizzi, Federica, additional, Branchi, Federica, additional, Donato, Francesca Maria, additional, and Elli, Luca, additional

Published
2020
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32. Intestinal Barrier Function in Gluten-Related Disorders

Author

Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Moerkens, Renée, Withoff, Sebo, Branchi, Federica, and Schumann, Michael

Subjects
Glutens, non-celiac wheat sensitivity, lcsh:TX341-641, Review, Wheat Hypersensitivity, Gastrointestinal Agents, Intestine, Small, Animals, Humans, Intestinal Mucosa, Tight Junction Proteins, Bacteria, non-celiac gluten sensitivity, food and beverages, nutritional and metabolic diseases, Immunity, Innate, digestive system diseases, Gastrointestinal Microbiome, wheat allergy, Intestinal Absorption, Host-Pathogen Interactions, epithelial barrier, permeability, Oligopeptides, lcsh:Nutrition. Foods and food supply, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, celiac disease, Signal Transduction
Abstract

Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the contact of the gastrointestinal mucosa with components of wheat and other cereals as a causative factor, these clinical entities have distinct pathophysiological pathways. In celiac disease, a T-cell mediate immune reaction triggered by gluten ingestion is central in the pathogenesis of the enteropathy, while wheat allergy develops as a rapid immunoglobulin E- or non-immunoglobulin E-mediated immune response. In non-celiac wheat sensitivity, classical adaptive immune responses are not involved. Instead, recent research has revealed that an innate immune response to a yet-to-be-defined antigen, as well as the gut microbiota, are pivotal in the development in this disorder. Although impairment of the epithelial barrier has been described in all three clinical conditions, its role as a potential pathogenetic co-factor, specifically in celiac disease and non-celiac wheat sensitivity, is still a matter of investigation. This article gives a short overview of the mucosal barrier of the small intestine, summarizes the aspects of barrier dysfunction observed in all three gluten-related disorders and reviews literature data in favor of a primary involvement of the epithelial barrier in the development of celiac disease and non-celiac wheat sensitivity.

Published
2019

33. THE ROLE OF FLOW CYTOMETRY IN COMPLICATED CELIAC DISEASE

Author

BRANCHI, FEDERICA

Abstract

Background Refractory celiac disease (RCD) is defined as persistence or recurrence of clinical symptoms of malabsorption and histologic signs of villous atrophy despite at least 1 year of strict adherence to a gluten-free diet. Two different entities of RCD have been described: RCD I shows a polyclonal pattern of intraepithelial lymphocytes (IEL), while in RCD II a monoclonal transformation of IEL can be identified (usually detected by means of TCR clonality analysis). Patients with RCD II have a poorer prognosis and a high risk of development of enteropathy-associated T-cell lymphoma (EATL), so that it has recently been proposed to consider RCD II as a form of low-grade intraepithelial lymphoma (pre-EATL). Recently, flow cytometric analysis of isolated intestinal lymphocytes has been introduced as new diagnostic modality for the detection of aberrant intestinal lymphocytes (ILs) and as a stronger predictor of EATL development than gene clonality analysis. Aims The aims of this study were (i) to evaluate the presence of aberrant ILs in a cohort of non-celiac, celiac and RCD patients by means of flow cytometry, (ii) to verify whether there is an association between clinical characteristics of RCD patients and presence of aberrant ILs, (iii) to compare different ILs detection strategies with the purpose of validating a simpler strategy than the ones currently proposed and (iv) to evaluate whether flow cytometric analysis of aberrant ILs could accurately identify RCD II/pre-EATL patients in our cohort. Methods Flow cytometry analysis of intestinal lymphocytes isolated from duodenal biopsy specimens from RCD, uncomplicated CD patients and controls was performed. Several lymphocyte markers (CD3, CD4, CD8, CD7, CD103, TCR??) were applied in order to identify aberrant ILs, defined by means of several gating strategies including cytCD3+surfCD3-CD7+ and surfCD3-CD7+CD103+. Percentages of aberrant ILs as well as clinical characteristics in different patients groups were compared. Results A total of 130 flow cytometry assays were performed on 109 patients, including 42 controls, 21 active CD, 16 CD on GFD and 30 RCD. RCD patients were initially subgrouped according to the presence (TCRclon+, n=17) or absence (TCRclon-, n=13) of TCR clonality: the presence of elevated aberrant ILs was compared between the two subgroups, with elevated ILs detectable exclusively in the RCDclon+. Patients with elevated ILs also showed a significantly more severe malabsorption (assessed by a composite score). A cut-off of 11% aberrant ILs for the most reliable strategy allowed to identify 2 patients with EATL, as well as a small group of high-risk RCD (5/30) that were classified as RCDII/pre-EATL. According to low aberrant ILs levels, the other RCD patients (21/30) were classified as RCD I/low-risk RCD. However, this technique proved negative in 2 cases of overt EATL and was not able to correctly identify as ?high-risk RCD? one patient with ulcerative jejunitis (who later developed a EATL), as well as one patient in whom a diagnosis of gamma-delta T-cell lymphoma was made. In the setting of RCD, aberrant ILs assessment by means of flow cytometry showed a Specificity of 100% but a Sensitivity of 67% for the detection of pre-EATL/EATL Alternative, simpler gating strategies for aberrant ILs showed similar accuracy to the principal strategy, however these results need further validation. Conclusion In routine clinical practice, flow cytometry for the assessment of aberrant ILs could prove a simple and accurate predictor for high-risk RCD. However, its use as a diagnostic strategy to classify patients into RCD I (low risk) and RCD II/pre-EATL could lead to missing cases of RCD patients with elevated risk. In order to prevent the consequences of false negative results, a multifaceted diagnostic approach taking TCR clonality and clinical manifestations (i.e. malabsorption) into account could maximize accuracy.

Published
2018
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37. Correction: Roncoroni, L. et al. A Low FODMAP Gluten-Free Diet Improves Functional Gastrointestinal Disorders and Overall Mental Health of Celiac Disease Patients: A Randomized Controlled Trial. Nutrients 2018, 10, 1023

Author

Roncoroni, Leda, primary, Bascuñán, Karla, additional, Doneda, Luisa, additional, Scricciolo, Alice, additional, Lombardo, Vincenza, additional, Branchi, Federica, additional, Ferretti, Francesca, additional, Dell’Osso, Bernardo, additional, Montanari, Valeria, additional, Bardella, Maria, additional, and Elli, Luca, additional

Published
2019
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39. Small‐bowel capsule endoscopy in patients with celiac disease, axial versus lateral/panoramic view: Results from a prospective randomized trial.

Author

Branchi, Federica, Ferretti, Francesca, Orlando, Stefania, Tontini, Gian Eugenio, Penagini, Roberto, Vecchi, Maurizio, and Elli, Luca

Subjects
*CELIAC disease, *CAPSULE endoscopy, *GLUTEN-free diet
Abstract

Background and Aim: Capsule enteroscopy (CE) is recommended in the management of complicated celiac disease (CD). However, published data are derived from axial‐view capsule systems. No data are available on the use of lateral/panoramic view capsules. This study aimed at evaluating the diagnostic yield and efficacy of the lateral/panoramic versus the axial view capsule system in CD. Methods: Consecutive CD patients were enrolled in a prospective monocentric study. Each patient ingested an axial (PillCam SB3) and a lateral/panoramic (CapsoCam Plus) view capsule with a 3‐h interval in a randomized order. Two experts blindly evaluated the CE carried out. A third expert reviewed the videos in cases of discordance. Results: Twenty‐five CD patients were enrolled (four males, age at CE 51.2 ± 16.6 years, age at CD diagnosis 41.7 ± 20.6, years on a gluten‐free diet [GFD] 9.6 ± 9.4). Indications at CE were refractory CD in nine cases, non‐responsiveness to GFD in 10 and GFD non‐compliance in six. A positive finding was evidenced in 15 (60%) and 13 (52%) cases by CapsoCam and PillCam respectively (not significant). Atrophy was detected by both capsules. Considering the percentage of the small‐bowel mucosa presenting atrophy signs, mean values were 22% ± 35 and 20% ± 29 for lateral/panoramic and axial systems, respectively (not significant). Compared to duodenal histology, PillCam correctly identified 80% of patients with SB atrophy, whereas CapsoCam identified 73% of cases. Conclusions: Lateral/panoramic view CE is effective in the detection of small‐bowel atrophy in CD and presents good sensitivity and specificity when compared to histology. [ABSTRACT FROM AUTHOR]

Published
2020
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41. A Low FODMAP Gluten-Free Diet Improves Functional Gastrointestinal Disorders and Overall Mental Health of Celiac Disease Patients: A Randomized Controlled Trial

Author

Roncoroni, Leda, primary, Bascuñán, Karla, additional, Doneda, Luisa, additional, Scricciolo, Alice, additional, Lombardo, Vincenza, additional, Branchi, Federica, additional, Ferretti, Francesca, additional, Dell’Osso, Bernardo, additional, Montanari, Valeria, additional, Bardella, Maria, additional, and Elli, Luca, additional

Published
2018
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46. GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation

Author

Hinze, Christian, primary, Ruffert, Janett, additional, Walentin, Katharina, additional, Himmerkus, Nina, additional, Nikpey, Elham, additional, Tenstad, Olav, additional, Wiig, Helge, additional, Mutig, Kerim, additional, Yurtdas, Zeliha Yesim, additional, Klein, Janet D., additional, Sands, Jeff M., additional, Branchi, Federica, additional, Schumann, Michael, additional, Bachmann, Sebastian, additional, Bleich, Markus, additional, and Schmidt-Ott, Kai M., additional

Published
2017
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49. Ultrasound Elasticity Imaging Predicts Therapeutic Outcomes of Patients With Crohn’s Disease Treated With Anti-Tumour Necrosis Factor Antibodies

Author

Orlando, Stefania, primary, Fraquelli, Mirella, additional, Coletta, Marina, additional, Branchi, Federica, additional, Magarotto, Andrea, additional, Conti, Clara Benedetta, additional, Mazza, Stefano, additional, Conte, Dario, additional, Basilisco, Guido, additional, and Caprioli, Flavio, additional

Published
2017
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