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2. Space-resolved diffusing wave spectroscopy measurements of the macroscopic deformation and the microscopic dynamics in tensile strain tests

Author

Nagazi, M. -Y., Brambilla, G., Meunier, G., Marguerès, P., Périé, J. -N., and Cipelletti, L.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We couple a laser-based, space-resolved dynamic light scattering apparatus to a universal testing machine for mechanical extensional tests. We perform simultaneous optical and mechanical measurements on polyether ether ketone, a semi-crystalline polymer widely used in the industry. Due to the high turbidity of the sample, light is multiply scattered by the sample and the diffusing wave spectroscopy (DWS) formalism is used to interpret the data. Space-resolved DWS yields spatial maps of the sample strain and of the microscopic dynamics. An excellent agreement is found between the strain maps thus obtained and those measured by a conventional stereo-correlation bench. The microscopic dynamics reveals both affine motion and plastic rearrangements. Thanks to the extreme sensitivity of DWS to displacements as small as 1 nm, plastic activity and its spatial localization can be detected at an early stage of the sample deformation, making the technique presented here a valuable complement to existing material characterization methods., Comment: 9 pages, 5 figures

Published
2016
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3. Brambilla et al. Reply to a Comment by J. Reinhardt et al. on 'Probing the equilibrium dynamics of colloidal hard spheres above the mode-coupling glass transition'

Author

Brambilla, G., Masri, D. El, Pierno, M., Berthier, L., and Cipelletti, L.

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract

G. Brambilla et al. Reply to a Comment by J. Reinhardt et al. questioning the existence of equilibrium dynamics above the critical volume fraction of colloidal hard spheres predicted by mode coupling theory., Comment: To appear in Phys. Rev. Lett. Reply to a Comment by J. Reinhardt et al. (see arXiv:1010.2891), which questions the existence of equilibrium dynamics above the critical volume fraction of glassy colloidal hard spheres predicted by mode coupling theory

Published
2010
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5. Auto-correlations and long time memory of environment sound: The case of an Urban Park in the city of Milan (Italy)

Author

Benocci, R, Roman, H, Bisceglie, A, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Roman H. E., Bisceglie A., Angelini F., Brambilla G., Zambon G., Benocci, R, Roman, H, Bisceglie, A, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Roman H. E., Bisceglie A., Angelini F., Brambilla G., and Zambon G.

Abstract

We investigate the possible presence of ‘long time’ memory in the auto-correlations of biophonic activity of environment sound. The study is based on recordings taken at two sites located in the Parco Nord of Milan (Italy), characterized by a wooded land, rich in biodiversity and exposed to different sources and degrees of anthropogenic disturbances. The audio files correspond to a three-day recording campaign (1-min recording followed by 5-min pause), from (17:00) April 30 to (17:00) May 3, 2019, which have been transformed into ecoacoustic indices time series. The following eight indices have been computed: Acoustic Complexity Index (ACI), Acoustic Diversity Index (ADI), Acoustic Evenness Index (AEI), Bio-acoustic Index (BI), Acoustic Entropy Index (H), Acoustic Richness index (AR), Normalized Difference Soundscape Index (NSDI) and Dynamic Spectral Centroid (DSC). We have grouped the indices carrying similar sound information by performing a principal component analysis (PCA). This allows us to reduce the number of variables from eight to three by retaining a large (≳80%) variance of the original variables. The time series corresponding to the reduced set of new variables have been analyzed, and both seasonal and possible long term trend components have been extracted. We find that no trends are present, i.e. the resulting time series are stationary, and the auto-correlations of the three selected PCA dimensions and associated residuals (obtained after extracting the seasonal components) can be determined. The calculations reveal the presence of a “memory” of few (≲5) hours long in the environment sound, for the two sites considered, which is quantified by the Hurst exponent, H. For Site 1, we find an overall effective Hurst exponent, Hdim≃0.88, for all three dimensions, and Hres≃0.75 for the residuals. For Site 2, the exponents are slightly smaller, amounting to 0.80 and 0.60, respectively. We attempt to correlate the Hurst exponents with a quality index obtained

Published
2022

8. THE IMMUNODEPRESSIVE ACTIVITY OF N-DIAZOACETYLGLYCINE AMIDE IN SOME TRANSPLANTATION SYSTEMS

Author

Brambilla, G, Parodi, S, CAVANNA, M, and Baldini, L

Abstract

Short intensive treatment with N-diazoacetylglycine amide (DGA) significantly prolonged the median survival time of skin grafts in H-2-incompatible mice and was effective in allowing the growth of L1210 leukemia allografts in the C57BL/6 strain and the development of Ehrlich ascites carcinoma in immunized mice. Depending on the experimental model employed, maximal immunodepressive effects resulted from the administration of DGA before or shortly after the antigen, and its effectiveness was comparable with, or even higher than that of, azathioprine to be rather long lasting, and its mode of action seemed to be different from that of azathioprine.

Published
2024

9. Surface-mounted tilt sensor using fiber Bragg grating technology for engineered slope monitoring with temperature compensation

Author

Sa’ad, M. S. M., primary, Ahmad, H., additional, Alias, M. A., additional, Zaini, M. K. A., additional, Lim, K. S., additional, Harun, S. W., additional, Grattan, K. T. V., additional, Rahman, B. M. A., additional, Brambilla, G., additional, Reduan, S. A., additional, Bayang, L., additional, and Ismail, M. F., additional

Published
2023
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11. Methods for noise event detection and assessment of the sonic environment by the harmonica index

Author

Alsina-Pages, R, Benocci, R, Brambilla, G, Zambon, G, Alsina-Pages R. M., Benocci R., Brambilla G., Zambon G., Alsina-Pages, R, Benocci, R, Brambilla, G, Zambon, G, Alsina-Pages R. M., Benocci R., Brambilla G., and Zambon G.

Abstract

Noise annoyance depends not only on sound energy, but also on other features, such as those in its spectrum (e.g., low frequency and/or tonal components), and, over time, amplitude fluctuations, such as those observed in road, rail, or aircraft noise passages. The larger these fluctuationsthe more annoying a sound is generally perceived. Many algorithms have been implemented to quantify these fluctuations and identify noise events, either by looking at transients in the sound level time history, such as exceedances above a fixed or time adaptive threshold, or focusing on the hearing perception process of such events. In this paper, four criteria to detect sound were applied to the acoustic monitoring data collected in two urban areas, namely Andorra la Vella, Principality of Andorra, and Milan, Italy. At each site, the 1 s A-weighted short LAeq,1s time history, 10 min long, was available for each hour from 8:00 a.m. to 7:00 p.m. The resulting 92-time histories cover a reasonable range of urban environmental noise time patterns. The considered criteria to detect noise events are based on: (i) noise levels exceeding by +3 dB the continuous equivalent level LAeqT referred to the measurement time (T), criteria used in the definition of the Intermittency Ratio (IR) to detect noise events; (ii) noise levels exceeding by +3 dB the running continuous equivalent noise level; (iii) noise levels exceeding by +10 dB the 50th noise level percentile; (iv) progressive positive increments of noise levels greater than 10 dB from the event start time. Algorithms (iii) and (iv) appear suitable for notice-event detection; that is, those that (for their features) are clearly perceived and potentially annoy exposed people. The noise events detected by the above four algorithms were also evaluated by the available anomalous noise event detection (ANED) procedure to classify them as produced by road traffic noise or something else. Moreover, the assessment of the sonic environment by the H

Published
2021

12. Eco-acoustic assessment of an urban park by statistical analysis

Author

Benocci, R, Roman, H, Bisceglie, A, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Roman H. E., Bisceglie A., Angelini F., Brambilla G., Zambon G., Benocci, R, Roman, H, Bisceglie, A, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Roman H. E., Bisceglie A., Angelini F., Brambilla G., and Zambon G.

Abstract

We investigated the statistical properties of the sounds recorded at a site located in the Parco Nord of Milan, Italy, characterized by wooded land rich in biodiversity and exposed to different sources and types of anthropogenic disturbances with the aim of deriving information on its environmental quality in terms of biophonic presence and athropic disturbance. A time series of eco-acosutic indices were determined for 616 audio files recorded from 30 April 2019 (5:00 p.m.) to 3 May 2019 (5:00 a.m.) with a 1-min duration followed by a 5-min pause (10 recordings per hour). In the present study, the following indices were computed: the Acoustic Complexity Index (ACI), Acoustic Diversity Index (ADI), Acoustic Evenness Index (AEI), Bio-acoustic Index (BI), Acoustic Entropy Index (H), Normalized Difference Soundscape Index (NSDI) and Dynamic Spectral Centroid (DSC). Cluster analysis performed on the corresponding time series yielded a dimensional reduction from seven down to three. The results show a clear separation of the eco-acoustic indices into two clusters, reflecting the different dynamics and diversity behaviour throughout the recordings. A post-processing aural survey was also performed, aiming at determining biophonic activities (mainly avian vocalization and other animals), the characteristics of technophonies sources (mainly road traffic noise and airplane fly-overs), human presence (voices and steps) and geophonies (rain and wind). The statistical analysis proved to be a robust tool due to the good matching obtained with the aural survey outcomes. The overall quality of the Parco Nord phonic activity was found to be low. Notwithstanding the presence of avian species, highlighted by the characteristic dawn chorus, both clusters revealed low “scores” of NDSI and DSC indices heavily influenced by road traffic sources. This study represents the first step toward the realization of maps of eco-acoustic indices for the long-term monitoring of fragile habitats.

Published
2021

13. Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic Study

Author

Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E. G., Piccinelli M. P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M. A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P. M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S. V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M. S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M. G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L. R., Rossi G., Tura G. B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V. F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., Laurenzi S., Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E. G., Piccinelli M. P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M. A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P. M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S. V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M. S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M. G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L. R., Rossi G., Tura G. B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V. F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., and Laurenzi S.

Abstract

Background: Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective: Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods: The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centres were assessed at baseline and at 6 and 12 months of follow-up. Psychopathology, drug attitude and treatment adherence were measured using the Brief Psychiatric Rating Scale, the Drug Attitude Inventory and the Kemp scale, respectively. Results: The study followed 394 participants for 12 months. The overall discontinuation rate at 12 months was 39.3% (95% confidence interval [CI] 34.4–44.3), with paliperidone LAI being the least discontinued LAI (33.9%; 95% CI 25.3–43.5) and olanzapine LAI the most discontinued (62.5%; 95% CI 35.4–84.8). The most frequent reason for discontinuation was onset of adverse events (32.9%; 95% CI 25.6–40.9) followed by participant refusal of the medication (20.6%; 95% CI 14.6–27.9). Medication adherence at baseline was negatively associated with discontinuation risk (hazard ratio [HR] 0.853; 95% CI 0.742–0.981; p = 0.026), whereas being prescribed olanzapine LAI was associated with increased discontinuation risk compared with being prescribed paliperidone LAI (HR 2.156; 95% CI 1.003–4.634; p = 0.049). Conclusions: Clinicians should be aware that LAI discontinuation is a frequent occurrence. LAI choice should be carefully discussed with the patient, tak

Published
2021

14. Audio recording analysis in an urban park of the city of Milan

Author

Dare T., Bolton S., Davies P., Xue Y., Ebbitt G., Benocci, R, Bisceglie, A, Angelini, F, Zambon, G, Brambilla, G, Roman, H, Benocci R., Bisceglie A., Angelini F., Zambon G., Brambilla G., Roman H. E., Dare T., Bolton S., Davies P., Xue Y., Ebbitt G., Benocci, R, Bisceglie, A, Angelini, F, Zambon, G, Brambilla, G, Roman, H, Benocci R., Bisceglie A., Angelini F., Zambon G., Brambilla G., and Roman H. E.

Abstract

A noise monitoring campaign has been performed in an urban park of Milan (Italy) called Parco Nord. The area of study is a large peri-urban park in the northern part of the city, characterized by wooded land rich in biodiversity and exposed to different sources and degrees of anthropogenic disturbances, such as road traffic noise and artificial light. The acoustic environment is rather complex due to the contemporary presence of different noise sources, leading to the difficult task of discriminating them in audio data. Due to these multifactorial characteristics, we evaluated different eco-acoustic indices in the attempt to derive a methodology to evaluate the potential of sound ecology indicators to discriminate the different types of sounds present in medium-large urban parks. Two different sites have been considered with different degree of anthropogenic disturbance. Time series of about two-week recordings have been transformed into eco-acoustics indices and statistically analysed. The results show a redistribution of recordings into two clusters associated with different sound components and different periods of the day. This allowed the identification of different degrees of biophonic and/or anthropogenic activities throughout the day in the two sites.

Published
2021

15. Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic Study

Author

Bertolini, F., Ostuzzi, G., Pievani, M., Aguglia, A., Bartoli, F., Bortolaso, P., Callegari, C., Caroleo, M., Carra, G., Corbo, M., D'Agostino, A., De Fazio, P., Magliocco, F., Martinotti, G., Ostinelli, E. G., Piccinelli, M. P., Tedeschi, F., Barbui, C., Boschello, F., Gastaldon, C., Mazzi, M. A., Nose, M., Papola, D., Perini, G., Piccoli, A., Purgato, M., Ruggeri, M., Terlizzi, S., Turrini, G., Raffaele, G., Cavallotti, S., Chirico, M., Ferrato, F., Limosani, I., Mastromo, D., Monzani, E., Porcellana, M., Restaino, F., Annese, P. M., Bolognesi, S., Cerretini, M., De Capua, A., Debolini, S., Del Zanna, M., Fargnoli, F., Giannini, A., Luccarelli, L., Lucii, C., Pierantozzi, E., Tozzi, F., Bardicchia, F., Cardamone, G., Facchi, E., Magnani, N., Soscia, F., Biancosino, B., Zotos, S., Giacomin, M., Pompei, F., Spano, M., Zonta, F., Buzzi, A., Callegred, C., Calzolari, R., Caselli, I., Diurni, M., Giana, E., Ielmini, M., Milano, A., Poloni, N., Sani, E., Zizolfi, D., Alberini, G., Cazzamalli, S., Costantini, C., Di Caro, A., Paronelli, C., Piantanida, S., Piccinelli, M., Alessandro, P., Barbanti, S. V., D'Ippolito, C., Gozzi, M., Moretti, V., Campese, O., Di Capro, L., di Giannantonio, M., Fiori, F., Lorusso, M., Mancini, V., Viceconte, D., Calandra, C., Luca, M., Signorelli, M. S., Suraniti, F., Balzarro, B., Boncompagni, G., Caretto, V., Emiliani, R., Lupoli, P., Menchetti, M., Rossi, E., Storbini, V., Tarricone, I., Terzi, L., Boso, M., Catania, C., De Paoli, G., Risaro, P., Aspesi, F., Bava, M., Bono, A., Brambilla, G., Castagna, G., Lucchi, S., Nava, R., Provenzi, M., Tabacchi, T., Tremolada, M., Verrengia, E., Barchiesi, M., Oriani, M. G., Pacetti, M., Ferro, M., Ghio, L., Beneduce, R., Laffranchini, L., Magni, L. R., Rossi, G., Tura, G. B., Addeo, L., Balletta, G., De Vivo, E., Di Benedetto, R., Parise, V. F., Carpiniello, B., Pinna, F., Pecile, D., Mattei, C., Bonavigo, T., Fabrici, E. P., Panarello, S., Peresson, G., Vitucci, C., Gardellin, F., Strizzolo, S., Cossetta, E., Fizzotti, C., Moretti, D., Di Gregorio, L., Sozzi, F., Colli, G., La Barbera, D., Laurenzi, S., Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E.G., Piccinelli M.P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M.A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P.M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Callegred C., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S.V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M.S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M.G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L.R., Rossi G., Tura G.B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V.F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E.P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., and Laurenzi S.

Subjects
Male, Pediatrics, respectively), 0302 clinical medicine, Delayed-Action Preparation, Brief Psychiatric Rating Scale, Pharmacology (medical), he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy, Original Research Article, Prospective Studies, Prospective cohort study, treatment, Mental Disorders, Hazard ratio, whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%, Psychiatric Status Rating Scale, Middle Aged, side efects, Psychiatry and Mental health, Italy, Mental Disorder, Female, he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy, occurring in almost 40% of the entire sample, side efects, participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%, respectively), whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%, respectively). In multivariate analysis, being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk, Human, Antipsychotic Agents, medicine.drug, Psychopathology, Adult, medicine.medical_specialty, Discontinuation, Follow-Up Studie, Medication Adherence, 03 medical and health sciences, medicine, Humans, Paliperidone, Adverse effect, Settore MED/25 - Psichiatria, discontinuation rates, Psychiatric Status Rating Scales, respectively). In multivariate analysis, business.industry, Long-Acting Antipsychotic, long-acting injectable antipsychotics, Survival Analysis, Confidence interval, participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%, 030227 psychiatry, Prospective Studie, Antipsychotic Agent, occurring in almost 40% of the entire sample, Delayed-Action Preparations, Neurology (clinical), business, 030217 neurology & neurosurgery, being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk, Follow-Up Studies
Abstract

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centres were assessed at baseline and at 6 and 12 months of follow-up. Psychopathology, drug attitude and treatment adherence were measured using the Brief Psychiatric Rating Scale, the Drug Attitude Inventory and the Kemp scale, respectively. Results The study followed 394 participants for 12 months. The overall discontinuation rate at 12 months was 39.3% (95% confidence interval [CI] 34.4–44.3), with paliperidone LAI being the least discontinued LAI (33.9%; 95% CI 25.3–43.5) and olanzapine LAI the most discontinued (62.5%; 95% CI 35.4–84.8). The most frequent reason for discontinuation was onset of adverse events (32.9%; 95% CI 25.6–40.9) followed by participant refusal of the medication (20.6%; 95% CI 14.6–27.9). Medication adherence at baseline was negatively associated with discontinuation risk (hazard ratio [HR] 0.853; 95% CI 0.742–0.981; p = 0.026), whereas being prescribed olanzapine LAI was associated with increased discontinuation risk compared with being prescribed paliperidone LAI (HR 2.156; 95% CI 1.003–4.634; p = 0.049). Conclusions Clinicians should be aware that LAI discontinuation is a frequent occurrence. LAI choice should be carefully discussed with the patient, taking into account individual characteristics and possible obstacles related to the practicalities of each formulation. Supplementary Information The online version contains supplementary material available at 10.1007/s40263-021-00809-w.

Published
2021

18. Analysis of noise annoyance complaints in the city of Milan, Italy

Author

Zambon, G, Muchetti, S, Salvi, D, Angelini, F, Brambilla, G, Benocci, R, Zambon G., Muchetti S. S., Salvi D., Angelini F., Brambilla G., Benocci R., Zambon, G, Muchetti, S, Salvi, D, Angelini, F, Brambilla, G, Benocci, R, Zambon G., Muchetti S. S., Salvi D., Angelini F., Brambilla G., and Benocci R.

Abstract

The paper describes the analysis of noise annoyance complaints submitted by citizens to the Municipality of Milan, Italy, from years 2000 to 2015. These complaints have been organized in a database and analysed according to: i) types of noise sources (technical facilities, music, transport infrastructures, etc.), ii) activities (retail and catering businesses, production, service sector, etc.) and iii) outcomes of the complaints inspection by local authorities. In addition, by means of a Geographic Information System (GIS) software, the spatial distribution of complaints has been determined according to the noise source type and activities, including also a geo-statistical representation by complaints density maps. The results show that, despite the dominant noise source in urban areas is mainly the road traffic, the other noises, such as those from industrial facilities, constructions and social activities (parties, fairs and open air markets, residential noise, etc.), are perceived as more disturbing. Since 2007, the number of noise complaints (about 100-150 complaints/year) is almost constant across the years. However, these complaints are expected to increase due to the growing and spreading of leisure activities, malls, exhibition centres and event venues, observed for the years 2014-2015.

Published
2020

19. Classification of urban road traffic noise based on sound energy and eventfulness indicators

Author

Brambilla, G, Benocci, R, Confalonieri, C, Roman, H, Zambon, G, Brambilla G., Benocci R., Confalonieri C., Roman H. E., Zambon G., Brambilla, G, Benocci, R, Confalonieri, C, Roman, H, Zambon, G, Brambilla G., Benocci R., Confalonieri C., Roman H. E., and Zambon G.

Abstract

Noise energetic indicators, like Lden, show good correlations with long term annoyance, but should be supplemented by other parameters describing the sound fluctuations, which are very common in urban areas and negatively impact noise annoyance. Thus, in this paper, the hourly values of continuous equivalent level LAeqh and the intermittency ratio (IR) were both considered to describe the urban road traffic noise, monitored in 90 sites in the city of Milan and covering different types of road, from motorways to local roads. The noise data have been processed by clustering methods to detect similarities and to figure out a criterion to classify the urban sites taking into account both equivalent noise levels and road traffic noise events. Two clusters were obtained and, considering the cluster membership of each site, the decimal logarithm of the day-time (06:00-22:00) traffic flow was used to associate each new road with the clusters. In particular, roads with average day-time hourly traffic flow ≥1900 vehicles/hour were associated with the cluster with high traffic flow. The described methodology could be fruitfully applied on road traffic noise data in other cities.

Published
2020

20. Eco-acoustic indices to evaluate soundscape degradation due to human intrusion

Author

Benocci, R, Brambilla, G, Bisceglie, A, Zambon, G, Benocci R., Brambilla G., Bisceglie A., Zambon G., Benocci, R, Brambilla, G, Bisceglie, A, Zambon, G, Benocci R., Brambilla G., Bisceglie A., and Zambon G.

Abstract

The characterization of environmental quality and the detection of the first sign of environmental stress, with reference to human intrusion, is currently a very important goal to prevent further environmental degradation, and consequently habitat destruction, in order to take appropriate preservation measures. Besides the traditional field observation and satellite remote sensing, geophonic and/or biophonic sounds have been proposed as potential indicators of terrestrial and aquatic settings’ status. In this work, we analyze a series of short audio-recordings taken in urban parks and bushes characterized by the presence of different human-generated-noise and species abundance. This study aims to propose a tool devoted to the investigation of urban and natural environments in a context with different soundscape qualities, such as, for example, those that can be found in urban parks. The analysis shows the ways in which it is possible to distinguish among different habitats by the use of a combination of different acoustic and sound ecology indices.

Published
2020

21. Spatial analysis and temporal trend of registered noise complaints in the city of Milan, Italy

Author

Benocci, R, Muchetti, S, Salvi, D, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Muchetti S. S., Salvi D., Angelini F., Brambilla G., Zambon G., Benocci, R, Muchetti, S, Salvi, D, Angelini, F, Brambilla, G, Zambon, G, Benocci R., Muchetti S. S., Salvi D., Angelini F., Brambilla G., and Zambon G.

Abstract

Noise complaints, expressed by individuals or a group of people, are the outcome of a complex behaviour depending not only on the noise exposure and its evoked annoyance, but also on other factors such as socio-economic ones. Noise annoyance has significant impacts on the quality of life and health of inhabitants, as well as social cohesion. Thus, noise complaints are a very important issue to tackle for national and local policy makers and for all stakeholders involved in planning and management of noise mitigation actions. Within the above framework, the present study describes the analysis of noise complaints submitted by citizens to the municipality of Milan, Italy, from years 2000 to 2015. These complaints have been organized in a database and analyzed considering: i) types of noise source (technical facilities, music, transport infrastructures, etc.); ii) business/leisure activities (retail and catering businesses, production, service sector, etc.) and iii) outcomes of the complaints inspection by local authorities. In addition, by means of a GIS software, the territorial distribution of noise complaints has been determined according to the noise source category and disturbing activity. This analysis includes also a geo-statistical representation by density maps. The results show that, even though road traffic is the dominant noise source in residential and urban areas, the perception of other noises, such as those from industrial facilities, civil construction and social activities (parties, fairs and open air markets, residential noise, etc.), is perceived as more annoying. The results show that since 2007 the number of noise complaints (about 100-150 complaints/year) remains almost constant across the years. However, the spreading of leisure activities, malls, exhibition centers and venues, as observed for the years 2014-2015, would most likely grow them even more. This outcome can assist the local authority in the management of the activities in order to r

Published
2020

22. Clinical correlates of paliperidone palmitate and aripiprazole monohydrate prescription for subjects with schizophreniaspectrum disorders: Findings from the STAR Network Depot Study

Author

Barbui C, Nosè M, Purgato M, Turrini G, Ostuzzi G, Mazzi MA, Papola D, Gastaldon C, Terlizzi S, Bertolini F, Piccoli A, Ruggeri M, De Fazio P, Magliocco F, Caroleo M, Raffaele G, D'Agostino A, Ostinelli EG, Chirico M, Cavallotti S, Lucii C, Bolognesi S, Debolini S, Pierantozzi E, Fargnoli F, Del Zanna M, Giannini A, Luccarelli L, De Capua A, Annese PM, Cerretini M, Tozzi F, Magnani N, Cardamone G, Bardicchia F, Facchi E, Soscia F, Zotos S, Biancosino B, Zonta F, Pompei F, Callegari C, Zizolfi D, Poloni N, Ielmini M, Caselli I, Giana E, Buzzi A, Diurni M, Milano A, Sani E, Calzolari R, Bortolaso P, Piccinelli M, Cazzamalli S, Alberini G, Piantanida S, Costantini C, Paronelli C, Di Caro A, Moretti V, Gozzi M, D'Ippolito C, Barbanti SV, Papalini A, Corbo M, Martinotti G, Campese O, Fiori F, Lorusso M, Di Capro L, Viceconte D, Mancini V, Suraniti F, Signorelli MSI, Rossi E, Lupoli P, Menchetti M, Terzi L, Boso M, Risaro P, De Paoli G, Catania C, Tarricone I, Caretto V, Storbini V, Emiliani R, Balzarro B, Carrà G, Bartoli F, Tabacchi T, Nava R, Bono A, Provenzi M, Brambilla G, Aspesi F, Trotta G, Tremolada M, Castagna G, Bava M, Verrengia E, Lucchi S, Oriani MG, Barchiesi M, Pacetti M, Aguglia A, Magni LR, Rossi G, Beneduce R, Tura GB, Laffranchini L, Mastromo D, Ferrato F, Restaino F, Monzani E, Porcellana M, Limosani I, Ghio L, Ferro M, Parise VF, Balletta G, Addeo L, De Vivo E, Di Benedetto R, Pinna F, Carpiniello B, Spano M, Giacomin M, Pecile D, Mattei C, Fabrici EP, Panarello S, Peresson G, Vitucci C, Bonavigo T, Perini G, Boschello F, Strizzolo S, Gardellin F, Di Giannantonio M, Moretti D, Fizzotti C, Cossetta E, Di Gregorio L, Sozzi F, Boncompagni G, La Barbera D, Colli G, Laurenzi S, Calandra C, Luca M, Crocamo C, STAR Network Depot Investigators, Bartoli F., Ostuzzi G., Crocamo C., Corbo M., D'Agostino A., Martinotti G., Ostinelli E.G., Tabacchi T., Barbui C., Carr G., Nose M., Purgato M., Turrini G., Mazzi M.A., Papola D., Gastaldon C., Terlizzi S., Bertolini F., Piccoli A., Ruggeri M., De Fazio P., Magliocco F., Caroleo M., Raffaele G., Chirico M., Cavallotti S., Lucii C., Bolognesi S., Debolini S., Pierantozzi E., Fargnoli F., Del Zanna M., Giannini A., Luccarelli L., De Capua A., Annese P.M., Cerretini M., Tozzi F., Magnani N., Cardamone G., Bardicchia F., Facchi E., Soscia F., Zotos S., Biancosino B., Zonta F., Pompei F., Callegari C., Zizolfi D., Poloni N., Ielmini M., Caselli I., Giana E., Buzzi A., Diurni M., Milano A., Sani E., Calzolari R., Bortolaso P., Piccinelli M., Cazzamalli S., Alberini G., Piantanida S., Costantini C., Paronelli C., Di Caro A., Moretti V., Gozzi M., D'Ippolito C., Barbanti S.V., Papalini A., Campese O., Fiori F., Lorusso M., Di Capro L., Viceconte D., Mancini V., Suraniti F., Signorelli M.S., Rossi E., Lupoli P., Menchetti M., Terzi L., Boso M., Risaro P., De Paoli G., Catania C., Tarricone I., Caretto V., Storbini V., Emiliani R., Balzarro B., Carra G., Nava R., Bono A., Provenzi M., Brambilla G., Aspesi F., Trotta G., Tremolada M., Castagna G., Bava M., Verrengia E., Lucchi S., Oriani M.G., Barchiesi M., Pacetti M., Aguglia A., Magni L.R., Rossi G., Beneduce R., Tura G.B., Laffranchini L., Mastromo D., Ferrato F., Restaino F., Monzani E., Porcellana M., Limosani I., Ghio L., Ferro M., Parise V.F., Balletta G., Addeo L., De Vivo E., Di Benedetto R., Pinna F., Carpiniello B., Spano M., Giacomin M., Pecile D., Mattei C., Fabrici E.P., Panarello S., Peresson G., Vitucci C., Bonavigo T., Perini G., Boschello F., Strizzolo S., Gardellin F., Di Giannantonio M., Moretti D., Fizzotti C., Cossetta E., Di Gregorio L., Sozzi F., Boncompagni G., La Barbera D., Colli G., Laurenzi S., Calandra C., Luca M., Barbui C, Nosè M, Purgato M, Turrini G, Ostuzzi G, Mazzi MA, Papola D, Gastaldon C, Terlizzi S, Bertolini F, Piccoli A, Ruggeri M, De Fazio P, Magliocco F, Caroleo M, Raffaele G, D'Agostino A, Ostinelli EG, Chirico M, Cavallotti S, Lucii C, Bolognesi S, Debolini S, Pierantozzi E, Fargnoli F, Del Zanna M, Giannini A, Luccarelli L, De Capua A, Annese PM, Cerretini M, Tozzi F, Magnani N, Cardamone G, Bardicchia F, Facchi E, Soscia F, Zotos S, Biancosino B, Zonta F, Pompei F, Callegari C, Zizolfi D, Poloni N, Ielmini M, Caselli I, Giana E, Buzzi A, Diurni M, Milano A, Sani E, Calzolari R, Bortolaso P, Piccinelli M, Cazzamalli S, Alberini G, Piantanida S, Costantini C, Paronelli C, Di Caro A, Moretti V, Gozzi M, D'Ippolito C, Barbanti SV, Papalini A, Corbo M, Martinotti G, Campese O, Fiori F, Lorusso M, Di Capro L, Viceconte D, Mancini V, Suraniti F, Signorelli MSI, Rossi E, Lupoli P, Menchetti M, Terzi L, Boso M, Risaro P, De Paoli G, Catania C, Tarricone I, Caretto V, Storbini V, Emiliani R, Balzarro B, Carrà G, Bartoli F, Tabacchi T, Nava R, Bono A, Provenzi M, Brambilla G, Aspesi F, Trotta G, Tremolada M, Castagna G, Bava M, Verrengia E, Lucchi S, Oriani MG, Barchiesi M, Pacetti M, Aguglia A, Magni LR, Rossi G, Beneduce R, Tura GB, Laffranchini L, Mastromo D, Ferrato F, Restaino F, Monzani E, Porcellana M, Limosani I, Ghio L, Ferro M, Parise VF, Balletta G, Addeo L, De Vivo E, Di Benedetto R, Pinna F, Carpiniello B, Spano M, Giacomin M, Pecile D, Mattei C, Fabrici EP, Panarello S, Peresson G, Vitucci C, Bonavigo T, Perini G, Boschello F, Strizzolo S, Gardellin F, Di Giannantonio M, Moretti D, Fizzotti C, Cossetta E, Di Gregorio L, Sozzi F, Boncompagni G, La Barbera D, Colli G, Laurenzi S, Calandra C, Luca M, Crocamo C, STAR Network Depot Investigators, Bartoli, F, Ostuzzi, G, Crocamo, C, Corbo, M, D'Agostino, A, Martinotti, G, Ostinelli, E, Tabacchi, T, Barbui, C, and Carra, G

Subjects
Aripiprazole monohydrate, Long-acting injectable antipsychotics, Paliperidone palmitate, Schizophrenia, Adult, Antipsychotic Agents, Aripiprazole, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Medication Adherence, Paliperidone Palmitate, Practice Patterns, Physicians', Schizophrenic Psychology, Young Adult, Long-acting injectable antipsychotic, medicine.medical_specialty, medicine.medical_treatment, Aripiprazole monohydrate, Long-acting injectable antipsychotics, Paliperidone palmitate, Schizophrenia, Practice Patterns, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Brief Psychiatric Rating Scale, medicine, Pharmacology (medical), Antipsychotic, Settore MED/25 - Psichiatria, Practice, Physicians', business.industry, Health Knowledge, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Attitudes, Propensity score matching, Observational study, business, 030217 neurology & neurosurgery, medicine.drug, Psychopathology
Abstract

This study, based on the 'Servizi Territoriali Associati per la Ricerca' (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we included 195 subjects (n = 117 who started PPM1 and n = 78 aripiprazole monohydrate). Individuals were comparable in terms of age, gender, treatment years, recent hospitalizations, previous long-acting injectable antipsychotic treatments, additional oral treatments, attitude toward drugs, medication adherence, and alcohol/substance-related comorbidities. Subjects starting PP1M presented higher BPRS overall (P = 0.009), positive (P = 0.015), and negative (P = 0.010) symptom scores compared to subjects starting aripiprazole monohydrate. Results were confirmed by appropriate regression models and propensity score matching analysis. No differences were found comparing the other BPRS subscale scores: affect, resistance, and activation. Clinicians may be more prone to prescribe PPM1, rather than aripiprazole monohydrate, to subjects showing higher overall symptom severity, including positive and negative symptoms. No additional clinical factors influenced prescribing attitudes in our sample.

Published
2020

29. Temperature-independent vibration sensor based on Fabry–Perot interferometer using a fiber Bragg grating approach

Author

Syamil Mohd Sa’ad, M., Faizal Ismail, M., Khairol Annuar Zaini, M., Grattan, K. T. V., Rahman, B. M., Brambilla, G., Sing, L. K., and Ahmad, H.

Subjects
TK, General Engineering, Atomic and Molecular Physics, and Optics
Abstract

An innovative vibration sensor based on a Fabry-Perot Interferometer (FPI) using Fiber Bragg Grating (FBG) reflectors has been discussed in this work. The sensor has been designed to be compact and easy to fabricate and independent of temperature, to overcome limitations seen in some previous designs, providing an effective correction for temperature effects in FBG-based FPI (FBG-FPI) sensors. In this approach, light from a broadband source in the wavelength range 1500 – 1580 nm has been used to illuminate the FBGs used (having a reflective peak of 1547.42 nm), employing in this way a light source within the FPI optimum wavelength operating range of 1547.15 nm – 1547.80 nm. The sensor developed in this work has been shown able to capture a 3 kHz burst signal from a signal generator, in 1 Hz, 2 Hz, and 3 Hz intervals. In addition, the research carried out has revealed that the sensor could be used to capture sinusoidal signals at frequencies up to 9 kHz, creating a performance comparable with many existing conventional piezoelectric sensors. The ability to operate regardless of any ambient temperature changes (in the range from 26.5°C (room temperature) up until 80°C), opens the way to use such a sensor system over a wide range of engineering applications taking advantage of the next generation of FBG-based FPIs.

Published
2022
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30. Strain Sensor Based on Embedded Fiber Bragg Grating in Thermoplastic Polyurethane Using the 3D Printing Technology for Improved Sensitivity

Author

Ahmad, H., Alias, M. A., Ismail, M. F., Ismail, N. N., Zaini, M. K. A., Lim, K. S., Brambilla, G., Grattan, K. T. V., and Rahman, B. M.

Subjects
QA75, multiple-point strain measurement, TK, 3D printing technology, Applied optics. Photonics, Fiber-optic sensors, Atomic and Molecular Physics, and Optics, QC, Electronic, Optical and Magnetic Materials, fiber Bragg grating, TA1501-1820
Abstract

A new and easy-to-fabricate strain sensor has been developed, based on fiber Bragg grating (FBG) technology embedded into a thermoplastic polyurethane filament using a 3-dimensional (3D) printer. Taking advantage of the flexibility and elastic properties of the thermoplastic polyurethane material, the embedding of the FBG provides durable protection with enhanced flexibility and sensitivity, as compared to the use of a bare FBG. Results of an evaluation of its performance have shown that the FBG sensors embedded in this way can be applied effectively in the measurement of strain, with an average wavelength responsivity of 0.013 5 nm/cm of displacement for tensile strain and −0.014 2 nm/cm for compressive strain, both showing a linearity value of up to 99%. Furthermore, such an embedded FBG-based strain sensor has a sensitivity of ∼1.74 times greater than that of a bare FBG used for strain measurement and is well protected and suitable for in-the-field use. It is also observed that the thermoplastic polyurethane based (TPU-based) FBG strain sensor carries a sensitivity value of ∼2.05 times higher than that of the polylactic acid based (PLA-based) FBG strain sensor proving that TPU material can be made as the material of choice as a “sensing” pad for the FBG.

Published
2022

31. Unlocking further understanding of the atomisation mechanism of a pressurized metered dose inhaler

Author

Myatt, B. J., Versteeg, H. K., Hargrave, G. K., Long, E. J., Gavtash, B., Lewis, D. A., Church, T., and Brambilla, G.

Abstract

Pressurised metered dose inhalers (pMDI) are one of the most common devices to deliver therapeutic treatment to patients with asthma or COPD. The atomisation mechanism responsible for droplet production is poorly understood because of the short length and timescales involved, making experimental investigations to characterise fluid flow structures and spray formation processes difficult. This article reports the findings of new high-speed and high-resolution imaging and temperature measurements seeking to improve the fundamental understanding of the atomisation mechanism of the pMDI. An annular flow regime of gaseous core in liquid annulus was observed in the orifice. Shock diamonds within the flow, viewed via Schlieren imaging, confirmed experimentally for the first time the choked nature of the orifice exit flow. Propellant formulation flow in the orifice was found to be superheated to a degree that significant flashing and evaporation at the orifice exit is likely to take place. This information points to a hybrid mechanism of predominantly aerodynamic atomisation with significant liquid flashing upon exit from the orifice producing a near instantaneous formation of respirable droplets. Large irrespirable droplets are produced by two mechanisms; breakup of liquid slugs ejected from the orifice, due to unsteady transient fluid structures in the actuator sump and stripping of ligaments from a liquid pool around the orifice exit, which subsequently break up into large droplets in the periphery of the plume. This new understanding will aid development of next generation, high efficiency pMDIs, particularly those employing low global warming potential propellants such as HFA152a or HFO1234ze(E).

Published
2022
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32. Audio recording analysis in an urban park of the city of Milan

Author

Benocci R., Bisceglie A., Angelini F., Zambon G., Brambilla G., Roman H. E., Dare T., Bolton S., Davies P., Xue Y., Ebbitt G., Benocci, R, Bisceglie, A, Angelini, F, Zambon, G, Brambilla, G, and Roman, H

Subjects
anthropogenic disturbances, urban park soundscape, monitoring campaign
Abstract

A noise monitoring campaign has been performed in an urban park of Milan (Italy) called Parco Nord. The area of study is a large peri-urban park in the northern part of the city, characterized by wooded land rich in biodiversity and exposed to different sources and degrees of anthropogenic disturbances, such as road traffic noise and artificial light. The acoustic environment is rather complex due to the contemporary presence of different noise sources, leading to the difficult task of discriminating them in audio data. Due to these multifactorial characteristics, we evaluated different eco-acoustic indices in the attempt to derive a methodology to evaluate the potential of sound ecology indicators to discriminate the different types of sounds present in medium-large urban parks. Two different sites have been considered with different degree of anthropogenic disturbance. Time series of about two-week recordings have been transformed into eco-acoustics indices and statistically analysed. The results show a redistribution of recordings into two clusters associated with different sound components and different periods of the day. This allowed the identification of different degrees of biophonic and/or anthropogenic activities throughout the day in the two sites.

Published
2021

33. The anatomical location of lymphadenopathies at imaging predicts the risk of lymph node invasion at final pathology in patients with renal cell carcinoma

Author

Rosiello, G., primary, Fallara, G., additional, Basile, G., additional, Cignoli, D., additional, De Cobelli, F., additional, Brambilla, G., additional, Nocera, L., additional, Belladelli, F., additional, Colandrea, G., additional, Canibus, D., additional, Re, C., additional, Musso, G., additional, Cei, F., additional, Giancristofaro, C., additional, Briganti, A., additional, Bertini, R., additional, Necchi, A., additional, Raggi, D., additional, Mottrie, A., additional, Karakiewicz, P.I., additional, Montorsi, F., additional, Salonia, A., additional, Larcher, A., additional, and Capitanio, U., additional

Published
2022
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37. Contributors

Author

Boppart, S.A., primary, Brambilla, G., additional, Chan, K.L.A., additional, Daly, S.M., additional, Ding, M., additional, Dinish, U.S., additional, Douplik, A., additional, Erickson-Bhatt, S.J., additional, Fale, P.L.V., additional, Fang, Q., additional, Intes, X., additional, Jiang, L., additional, Kho, K.W., additional, Muhaseen, A., additional, Olivo, M., additional, Pandya, A., additional, Pu, Y., additional, Sadovoy, A., additional, Saiko, G., additional, Schelkanova, I., additional, Sharp, M.C., additional, Sun, C.-W., additional, Teh, C., additional, Venugopal, V., additional, Välisuo, P., additional, Wang, W., additional, and Wen, L., additional

Published
2015
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39. Sound ecology indicators applied to urban parks: a preliminary study

Author

Benocci, R., Brambilla, G., ALESSANDRO VINCENZO BISCEGLIE, Zambon, G., Benocci, R, Brambilla, G, Bisceglie, A, and Zambon, G

Subjects
Soundecology indicators, Urban parks, Sound source discrimination, Sound ecology indicators, Urban parks, Sound source discrimination
Abstract

In soundscape ecology, different acoustic indices have been developed to describe the acoustic environment, mainly in natural areas. Avian species are among the sources of natural sounds that positively influence the human perception of a natural environment. However, the acoustic environment is rather complex due to the contemporary presence of different sources, leading to the difficult task of discriminating these sources in audio data. This task is even more essential in medium-large urban parks, as they are often exposed to road traffic noise produced by surrounding roads and to anthropogenic sounds due to people using the park for different purposes. Such non-natural sounds can deteriorate the perceived soundscape quality of the park and, therefore, reduce its potential restorative function. The aim of this preliminary study is to evaluate the potential of sound ecology indicators for discriminating the different types of sounds present in medium-large urban parks. For this purpose, two environmental settings were considered: a large urban park surrounded by busy roads and a shrub-dominated area, the latter of which was used as a reference site for natural areas. The two sonic environments were characterized by the presence of different anthropogenic noises, especially in the urban park, and sounds from avian species. Sound ecology indicators, or their combinations, could help identify the urban park areas with higher biophonic activities and, therefore, the areas that offer greater relief and restorative value. Such information can be helpful for improving the use of parks by directing users towards areas with features more conducive to their enjoyment and consistent with their expectations

Published
2020

42. How can we manage the COVID-19 infodemics? A case study targeted to health workers in Italy

Author

Bertinato, L., Brambilla, G., de Castro, P., Rosi, A., Nisini, R., Barbaro, A., Gentili, D., Toni, F., Mistretta, A., Bucciardini, R., Carusi, D., Angelozzi, A., Busani, L., Costabile, E., Mochi, P., Caminada, S., Magurano, F., and Brusaferro, S.

Subjects
Evidence-Based Medicine, Informatics, Infodemics, Italy, Health Personnel, COVID-19, Health literacy, Civil Defense, Humans, Public Health, Health Literacy, Pandemics
Published
2021

44. Comorbidity status of deceased COVID-19 in-patients in Italy

Author

Vetrano, D. L., Tazzeo, C., Palmieri, L., Marengoni, A., Zucchelli, A., Lo Noce, C., Onder, G., Andrianou, X., Barbariol, P., Bella, A., Bellino, S., Benelli, E., Bertinato, L., Boros, S., Brambilla, G., Calcagnini, G., Canevelli, M., Castrucci, M. R., Censi, F., Ciervo, A., Colaizzo, E., D'Ancona, F., Del Manso, M., Di Benedetto, C., Donfrancesco, C., Fabiani, M., Facchiano, F., Filia, A., Floridia, M., Galati, F., Giuliano, M., Grisetti, T., Kodra, Y., Langer, M., Lega, I., Maiozzi, P., Malchiodi Albedi, F., Manno, V., Martini, M., Urdiales, A. M., Mattei, E., Meduri, C., Meli, P., Minelli, G., Nebuloni, M., Nistico, L., Nonis, M., Palmisano, L., Petrosillo, N., Pezzotti, P., Pricci, F., Punzo, O., Puro, V., Raparelli, V., Rezza, G., Riccardo, F., Rota, M. C., Salerno, P., Serra, D., Siddu, A., Stefanelli, P., Tamburo de Bella, M., Tiple, D., Unim, B., Vaianella, L., Vanacore, N., Vichi, M., Villani, E. R., Zona, A., and Brusaferro, S.

Subjects
Aging, medicine.medical_specialty, Short Communication, Disease, Type 2 diabetes, Comorbidity, Chronic disease, NO, 03 medical and health sciences, 0302 clinical medicine, COVID-19, Mortality, Multimorbidity, Risk Factors, Internal medicine, medicine, 80 and over, Diabetes Mellitus, Dementia, Humans, 030212 general & internal medicine, Stroke, Aged, Aged, 80 and over, COPD, business.industry, SARS-CoV-2, Atrial fibrillation, Italy, Diabetes Mellitus, Type 2, medicine.disease, 030228 respiratory system, Heart failure, Geriatrics and Gerontology, business, Type 2
Abstract

Background Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated. Methods A random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values ≥ 1.5. Results Six pairs of diseases exhibited O/E values ≥ 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity. Conclusion In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.

Published
2021

47. Surface-Mounted Tilt Sensor Using Fiber Bragg Grating Technology for Engineered Slope Monitoring With Temperature Compensation

Author

Sa'ad, M. S. M., Ahmad, H., Alias, M. A., Zaini, M. K. A., Lim, K. S., Harun, S. W., Grattan, K. T. V., Rahman, B. M. A., Brambilla, G., Reduan, S. A., Bayang, L., and Ismail, M. F.

Abstract

A surface-mounted tilt sensor was designed and fabricated to measure the inclination angle of engineered structures or slopes in two directions. The device utilizes two strain-sensitive fiber Bragg gratings (FBGs) for tilt angle measurement bidirectionally and one strain-free FBG to provide temperature compensation. In this work, a tilt sensor prototype was fabricated using a 3-D printer, with a robust enclosure and a miniature actuator with dimensions of $115\times 65\times30$ mm and $45\times 20\times $ 3 mm, respectively. The device was first calibrated in the laboratory for tilt and temperature parameters. For tilt calibration, the device yields a sensitivity value of 0.0135 and 0.0123 nm/° for + x- and– ${x}$ -directions. On the other hand, the device delivers a sensitivity value of 0.0105 nm/°C as the response to temperature changes. The tilt sensor was also tested for suitability in a real-field deployment where it was installed on a retaining wall and was left for four weeks. The field test data indicate no vertical displacement of the wall since the device exhibits zero inclination changes during the test period. This compact, robust, and easy-to-install tilt sensor has excellent potential for various geotechnical applications, mainly in landslide detections, ground movement, and engineered slope monitoring.

Published
2023
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49. Prevalence and clinical correlates of dementia among COVID-19-related deaths in Italy

Author

Canevelli, M., Palmieri, L., Raparelli, V., Lo Noce, C., Colaizzo, E., Tiple, D., Vaianella, L., Vanacore, N., Brusaferro, S., Onder, G., Bertinato, L., Brambilla, G., Calcagnini, G., Censi, F., Donfrancesco, C., Facchiano, F., Floridia, M., Giuliano, M., Grisetti, T., Kodra, Y., Langer, M., Lega, I., Albedi, F. M., Manno, V., Mattei, E., Meli, P., Minelli, G., Nebuloni, M., Nistico, L., Nonis, M., Palmisano, L., Petrosillo, N., Pricci, F., Punzo, O., Salerno, P., Debella, M. T., Taruscio, D., Unim, B., Vichi, M., Villani, E. R., and Zona, A.

Subjects
medicine.medical_specialty, Pediatrics, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Neurology, Short Report, lcsh:Geriatrics, lcsh:RC346-429, SARS‐CoV‐2, NO, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Intensive care, Medicine, Dementia, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Diagnostic Assessment & Prognosis, 0303 health sciences, business.industry, SARS-CoV-2, Public health, COVID-19, dementia, public health, Cognition, medicine.disease, lcsh:RC952-954.6, Psychiatry and Mental health, Concomitant, Population study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Introduction We aimed at exploring the proportion of patients dying with COVID‐19 and concomitant dementia in Italy, as well as their clinical characteristics and trajectories of care. Methods The proportion of COVID‐19‐related deaths occurring in people with dementia and the clinical characteristics of deceased individuals according to their dementia status were explored by considering the medical charts of a representative sample of patients deceased in Italian hospitals (n = 2621). Results A total of 415 individuals with dementia were identified in the study population, accounting for 15.8% of overall COVID‐19‐related deaths. Patients with dementia less frequently presented with cough, had lower chance of receiving supportive therapies and intensive care approaches, and showed a faster clinical worsening as compared with individuals with intact cognition. Discussion Dementia confers a relevant risk of adverse outcomes in case of SARS‐CoV‐2 infection and influences the clinical presentation, course and management of affected individuals.

Published
2020

50. Sex differences in clinical phenotype and transitions of care among individuals dying of COVID-19 in Italy

Author

Raparelli, V., Palmieri, L., Canevelli, M., Pricci, F., Unim, B., Lo Noce, C., Villani, E. R., Rochon, P. A., Pilote, L., Vanacore, N., Onder, G., Agazio, E., Andrianou, X., Barbariol, P., Bella, A., Bellino, S., Benelli, E., Bertinato, L., Boros, S., Brambilla, G., Calcagnini, G., Daqar, Q. Z., Castrucci, M. R., Censi, F., Ciervo, A., Colaizzo, E., D'Ancona, F., Delmanso, M., Donfrancesco, C., Fabiani, M., Facchiano, F., Filia, A., Floridia, M., Galati, F., Giuliano, M., Grisetti, T., Kodra, Y., Langer, M., Lega, I., Lonoce, C., Maiozzi, P., Malchiodialbedi, F., Manno, V., Martini, M., Urdiales, A. M., Mattei, E., Meduri, C., Meli, P., Minelli, G., Nebuloni, M., Nistico, L., Nonis, M., Palmisano, L., Petrosillo, N., Pezzotti, P., Punzo, O., Puro, V., Rezza, G., Riccardo, F., Rota, M. C., Salerno, P., Serra, D., Siddu, A., Stefanelli, P., Tamburo DeBella, M., Tiple, D., Vaianella, L., Vichi, M., Zona, A., and Brusaferro, S.

Subjects
Male, Multivariate analysis, covid-19, comorbidities, in-hospital complications, sex, transition of care, lcsh:Medicine, Disease, Comorbidity, 030204 cardiovascular system & hematology, Comorbidities, COVID-19, In-hospital complications, Sex, Transition of care, lcsh:Physiology, Aged, Aged, 80 and over, Betacoronavirus, Coronavirus Infections, Female, Hospitalization, Humans, Italy, Middle Aged, Multimorbidity, Multivariate Analysis, Pandemics, Patient Transfer, Pneumonia, Viral, Prevalence, Retrospective Studies, Risk Factors, SARS-CoV-2, Sex Factors, 0302 clinical medicine, Endocrinology, 80 and over, 030212 general & internal medicine, Viral, lcsh:QP1-981, Acute kidney injury, medicine.medical_specialty, NO, Gender Studies, 03 medical and health sciences, Internal medicine, medicine, Dementia, business.industry, Research, lcsh:R, Outbreak, Retrospective cohort study, Pneumonia, medicine.disease, business, Kidney disease
Abstract

Background Among the unknowns posed by the coronavirus disease 2019 (COVID-19) outbreak, the role of biological sex to explain disease susceptibility and progression is still a matter of debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed to assess if sex differences exist in the clinical manifestations and transitions of care among hospitalized individuals dying with laboratory-confirmed SARS-CoV-2 infection in Italy (February 27–June 11, 2020). Clinical characteristics and the times from symptoms’ onset to admission, nasopharyngeal swab, and death were compared between sexes. Adjusted multivariate analysis was performed to identify the clinical features associated with male sex. Results Of the 32,938 COVID-19-related deaths that occurred in Italy, 3517 hospitalized and deceased individuals with COVID-19 (mean 78 ± 12 years, 33% women) were analyzed. At admission, men had a higher prevalence of ischemic heart disease (adj-OR = 1.76, 95% CI 1.39–2.23), chronic obstructive pulmonary disease (adj-OR = 1.7, 95% CI 1.29–2.27), and chronic kidney disease (adj-OR = 1.48, 95% CI 1.13–1.96), while women were older and more likely to have dementia (adj-OR = 0.73, 95% CI 0.55–0.95) and autoimmune diseases (adj-OR = 0.40, 95% CI 0.25–0.63), yet both sexes had a high level of multimorbidity. The times from symptoms’ onset to admission and nasopharyngeal swab were slightly longer in men despite a typical acute respiratory illness with more frequent fever at the onset. Men received more often experimental therapy (adj-OR = 2.89, 95% CI 1.45–5.74) and experienced more likely acute kidney injury (adj-OR = 1.47, 95% CI 1.13–1.90). Conclusions Men and women dying with COVID-19 had different clinical manifestations and transitions of care. Identifying sex-specific features in individuals with COVID-19 and fatal outcome might inform preventive strategies.

Published
2020

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