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5. Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis

Author

Bertolaccini, Luca, primary, Cara, Andrea, additional, Chiari, Matteo, additional, Diotti, Cristina, additional, Glick, Nimrod, additional, Mohamed, Shehab, additional, Uslenghi, Clarissa, additional, Mazzella, Antonio, additional, Brambilla, Daniela, additional, Bertolotti, Raffaella, additional, Sedda, Giulia, additional, and Spaggiari, Lorenzo, additional

Published
2023
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12. Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study

Author

Spaggiari, Lorenzo, Marulli, Giuseppe, Bovolato, Pietro, Alloisio, Marco, Pagan, Vittore, Oliaro, Alberto, Ratto, Giovanni Battista, Facciolo, Francesco, Sacco, Rocco, Brambilla, Daniela, Maisonneuve, Patrick, Mucilli, Felice, Alessandrini, Gabriele, Leoncini, Giacomo, Ruffini, Enrico, Fontana, Paolo, Infante, Maurizio, Pariscenti, Gian Luca, Casiraghi, Monica, and Rea, Federico

Published
2014
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19. Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors

Author

Petrella, F, Frassoni, S, Bagnardi, V, Casiraghi, M, Brambilla, D, Diotti, C, Spaggiari, L, Petrella, Francesco, Frassoni, Samuele, Bagnardi, Vincenzo, Casiraghi, Monica, Brambilla, Daniela, Diotti, Cristina, Spaggiari, Lorenzo, Petrella, F, Frassoni, S, Bagnardi, V, Casiraghi, M, Brambilla, D, Diotti, C, Spaggiari, L, Petrella, Francesco, Frassoni, Samuele, Bagnardi, Vincenzo, Casiraghi, Monica, Brambilla, Daniela, Diotti, Cristina, and Spaggiari, Lorenzo

Abstract

Background Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease. The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. Methods Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. Results Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. Conclusion Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection.

Published
2020

21. Continuity of Cancer Care: The Surgical Experience of Two Large Cancer Hubs in London and Milan

Author

Monroy-Iglesias, Maria J., primary, Tagliabue, Marta, additional, Dickinson, Harvey, additional, Roberts, Graham, additional, De Berardinis, Rita, additional, Russell, Beth, additional, Moss, Charlotte, additional, Irwin, Sophie, additional, Olsburgh, Jonathon, additional, Cocco, Ivana Maria Francesca, additional, Schizas, Alexis, additional, McCrindle, Sarah, additional, Nath, Rahul, additional, Brunet, Aina, additional, Simo, Ricard, additional, Tornari, Chrysostomos, additional, Srinivasan, Parthi, additional, Prachalias, Andreas, additional, Davies, Andrew, additional, Geh, Jenny, additional, Fraser, Stephanie, additional, Routledge, Tom, additional, Ma, RuJun, additional, Doerge, Ella, additional, Challacombe, Ben, additional, Nair, Raj, additional, Hadjipavlou, Marios, additional, Scarpinata, Rosaria, additional, Sorelli, Paolo, additional, Dolly, Saoirse, additional, Mistretta, Francesco Alessandro, additional, Musi, Gennaro, additional, Casiraghi, Monica, additional, Aloisi, Alessia, additional, Dell’Acqua, Andrea, additional, Scaglione, Donatella, additional, Zanoni, Stefania, additional, Rampazio Da Silva, Daniele, additional, Brambilla, Daniela, additional, Bertolotti, Raffaella, additional, Peruzzotti, Giulia, additional, Maggioni, Angelo, additional, de Cobelli, Ottavio, additional, Spaggiari, Lorenzo, additional, Ansarin, Mohssen, additional, Mastrilli, Fabrizio, additional, Gandini, Sara, additional, Jain, Urvashi, additional, Hamed, Hisham, additional, Haire, Kate, additional, and Van Hemelrijck, Mieke, additional

Published
2021
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27. Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors.

Author

Petrella, Francesco, Frassoni, Samuele, Bagnardi, Vincenzo, Casiraghi, Monica, Brambilla, Daniela, Diotti, Cristina, and Spaggiari, Lorenzo

Subjects
LUNG cancer, SURGICAL excision, TUMOR classification, SURGICAL complications, METASTASIS
Abstract

Background Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease. The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. Methods Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. Results Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. Conclusion Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Carinal resection: technical tips

Author

Casiraghi, Monica, primary, Mariolo, Alessio Vincenzo, additional, Galetta, Domenico, additional, Petrella, Francesco, additional, Brambilla, Daniela, additional, and Spaggiari, Lorenzo, additional

Published
2018
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34. Endobronchial Ultrasound Transbronchial Needle Aspiration in Thoracic Diseases: Much More than Mediastinal Staging

Author

Guarize, Juliana, primary, Casiraghi, Monica, additional, Donghi, Stefano, additional, Diotti, Cristina, additional, Vanoni, Nicolo, additional, Romano, Rosalia, additional, Casadio, Chiara, additional, Brambilla, Daniela, additional, Maisonneuve, Patrick, additional, Petrella, Francesco, additional, and Spaggiari, Lorenzo, additional

Published
2018
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35. EBUS-TBNA in PET-positive lymphadenopathies in treated cancer patients

Author

Guarize, Juliana, primary, Casiraghi, Monica, additional, Donghi, Stefano, additional, Casadio, Chiara, additional, Diotti, Cristina, additional, Filippi, Niccolò, additional, Di Tonno, Clementina, additional, Midolo, Valeria, additional, Maisonneuve, Patrick, additional, Brambilla, Daniela, additional, Grana, Chiara Maria, additional, Petrella, Francesco, additional, and Spaggiari, Lorenzo, additional

Published
2017
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36. An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers

Author

Dama, Elisa, primary, Melocchi, Valentina, additional, Dezi, Fabio, additional, Pirroni, Stefania, additional, Carletti, Rose Mary, additional, Brambilla, Daniela, additional, Bertalot, Giovanni, additional, Casiraghi, Monica, additional, Maisonneuve, Patrick, additional, Barberis, Massimo, additional, Viale, Giuseppe, additional, Vecchi, Manuela, additional, Spaggiari, Lorenzo, additional, Bianchi, Fabrizio, additional, and Di Fiore, Pier Paolo, additional

Published
2017
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37. Ten Years' Experience in Robotic-Assisted Thoracic Surgery for Early Stage Lung Cancer.

Author

Casiraghi, Monica, Galetta, Domenico, Borri, Alessandro, Tessitore, Adele, Romano, Rosalia, Diotti, Cristina, Brambilla, Daniela, Maisonneuve, Patrick, and Spaggiari, Lorenzo

Subjects
THORACIC surgery, PNEUMONECTOMY, NON-small-cell lung carcinoma, LUNG cancer, TUMOR classification, LYMPHADENECTOMY
Abstract

Background This study analyzed the short- and long-term outcomes of robotic-assisted thoracic surgery (RATS) for early stage non-small cell lung cancer (NSCLC). Methods From November 2006 to December 2016, we performed 363 RATS procedures. This study retrospectively reviewed 339 patients who underwent RATS for clinical stages I (n = 318) or II (n = 21) NSCLC. Results Twenty-nine patients underwent segmentectomy, 307 lobectomy, and 3 pneumonectomy. Conversion occurred in 22 patients (6.5%): 15 (4.4%) due to technical issues, 4 (1.2%) for oncological reasons, and 3 (0.9%) for bleeding. The median number of N1 and N2 stations resected was 2 and 3, respectively, and the median number of N1 and N2 lymph nodes resected was 9 and 6, respectively. Median operative time was 192 minutes for lobectomy, 172 minutes for segmentectomy, and 275 minutes for pneumonectomy. Median length of hospital stay was 5 days (2–191). The most common postoperative complication was prolonged air leak (12.1%). Major complications occurred in eight patients (2.4%). The 30-day and 90-day operative mortality was 0% and 0.3%, respectively. Two and 5-year cancer-specific survival rate was 96.1% and 91.5%, respectively. Five-year survival rate was 96.2% for patients who underwent segmentectomy, and 89.1% for lobectomy. All three patients who underwent pneumonectomy were alive at 5 years with no disease. Conclusions Besides the well-known short-term outcomes showing very low morbidity and mortality rates, mediastinal lymph node dissection during RATS adequately assesses lymph node stations detecting occult lymph node metastasis and leading to excellent oncologic results. However, these results await longer follow-up studies. [ABSTRACT FROM AUTHOR]

Published
2019
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39. EBUS-TBNA in positron emission tomography (PET) positive mediastinal lymph nodes in previously radically treated malignancies

Author

Guarize, Juliana, primary, Magni, Elena, additional, Casadio, Chiara, additional, Donghi, Stefano, additional, Filippi, Niccolo, additional, Midolo, Valeria, additional, Casiraghi, Monica, additional, Petrella, Francesco, additional, Brambilla, Daniela, additional, Maisonneuve, Patrick, additional, and Spaggiari, Lorenzo, additional

Published
2016
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40. AAI predicts patients’ in-session interpersonal behavior and discourse:A “move to the level of the relation” for attachment-informed psychotherapy research

Author

Talia, Alessandro, Daniel, Sarah Ingrid Franksdatter, Miller-Bottome, Madeleine, Brambilla, Daniela, Miccoli, Denise, Safran, Jeremy D., Lingiardi, Vittorio, Talia, Alessandro, Daniel, Sarah Ingrid Franksdatter, Miller-Bottome, Madeleine, Brambilla, Daniela, Miccoli, Denise, Safran, Jeremy D., and Lingiardi, Vittorio

Published
2014

44. Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin‐responsive, multiple acyl‐CoA dehydrogenase deficiency patient

Author

Gianazza, Elisabetta, primary, Vergani, Lodovica, additional, Wait, Robin, additional, Brizio, Carmen, additional, Brambilla, Daniela, additional, Begum, Shajna, additional, Giancaspero, Teresa A., additional, Conserva, Francesca, additional, Eberini, Ivano, additional, Bufano, Daniela, additional, Angelini, Corrado, additional, Pegoraro, Elena, additional, Tramontano, Anna, additional, and Barile, Maria, additional

Published
2006
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47. AAI predicts patients’ in-session interpersonal behavior and discourse: a “move to the level of the relation” for attachment-informed psychotherapy research.

Author

Talia, Alessandro, Daniel, Sarah I.F., Miller-Bottome, Madeleine, Brambilla, Daniela, Miccoli, Denise, Safran, Jeremy D., and Lingiardi, Vittorio

Abstract

There is currently little empirical evidence regarding how patients’ attachment patterns manifest in individual psychotherapy. This study compared the in-session discourse of patients classified secure, dismissing, and preoccupied on the Adult Attachment Interview (AAI). Rather than focusing on content or form alone, this study analyzed how patients’ discourse elicits and maintains emotional proximity with the therapist. The AAI was administered to 56 patients prior to treatment and one session for each patient was rated with the Patient Attachment Coding System (PACS) by four independent raters, blind to patients’ AAI classification. Significant differences were found in the discourse of patients with different attachment patterns. Namely, secure and preoccupied patients showed more contact-seeking behavior than dismissing patients, who avoided emotional proximity more, while preoccupied patients resisted therapists’ help more than did secure and dismissing patients. These results suggest that the different attachment patterns may have distinctive manifestations in the psychotherapy process that can be tracked by external observers. [ABSTRACT FROM AUTHOR]

Published
2014
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48. La postura prona nei pazienti con grave insufficienza respiratoria.

Author

Lucchini, Alberto, Pelucchi, Giulia, Gariboldi, Roberto, Vimercati, Simona, Brambilla, Daniela, Elli, Stefano, Bondi, Herman, De Felippis, Christian, Giacovelli, Matteo, Mascheroni, Magda, and Sasso, Maurizio

Subjects
PATIENT positioning, ADULT respiratory distress syndrome, INTENSIVE care nursing, NURSES, CONSCIOUS sedation, HOSPITAL beds
Abstract

Copyright of SCENARIO: Official Italian Journal of ANIARTI is the property of ANIARTI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010

49. Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors

Author

Daniela Brambilla, Samuele Frassoni, Monica Casiraghi, Lorenzo Spaggiari, Vincenzo Bagnardi, Francesco Petrella, Cristina Diotti, Petrella, F, Frassoni, S, Bagnardi, V, Casiraghi, M, Brambilla, D, Diotti, C, Spaggiari, L, Petrella, Francesco, Frassoni, Samuele, Bagnardi, Vincenzo, Casiraghi, Monica, Brambilla, Daniela, Diotti, Cristina, and Spaggiari, Lorenzo

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Bilateral lung neoplasms, Lung Neoplasms, Time Factors, Databases, Factual, Patient characteristics, Disease, 030204 cardiovascular system & hematology, Risk Assessment, surgery, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Risk Factors, Tumor stage, Long term outcomes, Medicine, Humans, Surgical treatment, Pneumonectomy, Aged, Retrospective Studies, Aged, 80 and over, Lung, business.industry, food and beverages, Retrospective cohort study, Neoplasms, Second Primary, Middle Aged, lung neoplasm, Surgery, medicine.anatomical_structure, Treatment Outcome, 030220 oncology & carcinogenesis, Observational study, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease.The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes. Methods Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Preoperative patient characteristics were noted, including demographic information, operative details, pathologic information including histology and tumor stage according to the eighth edition of the tumor nodes metastases staging system, and the use of neoadjuvant or adjuvant treatments. Results Patients receiving the second pulmonary resection more than 24 months from the first procedure as well as patients receiving bilateral lobectomies had higher overall 3-, 5-, and 10-year survival rates compared with the others. Conclusion Patients receiving the second resection more than 24 months from the first procedure have the best long-term results irrespective of the type of resection.

Published
2020

50. An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers

Author

Lorenzo Spaggiari, Daniela Brambilla, Giovanni Bertalot, Patrick Maisonneuve, Valentina Melocchi, Massimo Barberis, Stefania Pirroni, Rose Mary Carletti, Fabio Dezi, Giuseppe Viale, Elisa Dama, Monica Casiraghi, Manuela Vecchi, Pier Paolo Di Fiore, Fabrizio Bianchi, Dama, Elisa, Melocchi, Valentina, Dezi, Fabio, Pirroni, Stefania, Carletti, Rose Mary, Brambilla, Daniela, Bertalot, Giovanni, Casiraghi, Monica, Maisonneuve, Patrick, Barberis, Massimo, Viale, Giuseppe, Vecchi, Manuela, Spaggiari, Lorenzo, Bianchi, Fabrizio, and Di Fiore, Pier Paolo

Subjects
Male, Proteomics, 0301 basic medicine, Oncology, Cancer Research, Pathology, Lung Neoplasms, Kaplan-Meier Estimate, Disease, Cohort Studies, 0302 clinical medicine, Risk Factors, Medicine, DNA Copy Number Variation, Aged, 80 and over, Genomics, respiratory system, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cohort, Disease Progression, Adenocarcinoma, Female, Human, Cohort study, Adult, medicine.medical_specialty, DNA Copy Number Variations, Prognosi, Adenocarcinoma of Lung, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, Humans, Lung cancer, Aged, Neoplasm Staging, Proportional Hazards Models, Lung, business.industry, Proportional hazards model, Risk Factor, Gene Expression Profiling, Proteomic, DNA Methylation, medicine.disease, Lung Neoplasm, 030104 developmental biology, Mutation, Genomic, Proportional Hazards Model, Cohort Studie, business, Lung cancer screening
Abstract

Purpose: The National Lung Cancer Screening Trial has confirmed that lung cancer mortality can be reduced if tumors are diagnosed early, that is, at stage I. However, a substantial fraction of stage I lung cancer patients still develop metastatic disease within 5 years from surgery. Prognostic biomarkers are therefore needed to identify patients at risk of an adverse outcome, who might benefit from multimodality treatment. Experimental Design: We extensively validated a 10-gene prognostic signature in a cohort of 507 lung adenocarcinoma patients using formalin-fixed paraffin-embedded samples. Furthermore, we performed an integrated analysis of gene expression, methylation, somatic mutations, copy number variations, and proteomic profiles on an independent cohort of 468 patients from The Cancer Genome Atlas (TCGA). Results: Stage I lung cancer patients (N = 351) identified as high-risk by the 10-gene signature displayed a 4-fold increased risk of death [HR = 3.98; 95% confidence interval (CI), 1.73–9.14], with a 3-year overall survival of 84.2% (95% CI, 78.7–89.7) compared with 95.6% (92.4–98.8) in low-risk patients. The analysis of TCGA cohort revealed that the 10-gene signature identifies a subgroup of stage I lung adenocarcinomas displaying distinct molecular characteristics and associated with aggressive behavior and poor outcome. Conclusions: We validated a 10-gene prognostic signature capable of identifying a molecular subtype of stage I lung adenocarcinoma with characteristics remarkably similar to those of advanced lung cancer. We propose that our signature might aid the identification of stage I patients who would benefit from multimodality treatment. Clin Cancer Res; 23(1); 62–72. ©2016 AACR.

Published
2017
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