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1. It's my life : staying in control : developing a school-based intervention to facilitate adolescent behaviour change with respect to alcohol consumption

Author

Bragg, J.

Subjects
370.15
Abstract

Trends in adolescent alcohol consumption are declining, however remain a cause for concern. Research evidences a relationship between alcohol-related mortality and socioeconomic deprivation, more disadvantaged social groups tending to experience disproportionately higher levels of alcohol attributable harm. Amongst adolescents, there is an association between school disengagement and likelihood to engage with risky behaviours followed by poor academic outcomes. The social determinants for health and education overlap considerably, therefore the premise underpinning this study proposes that trying to improve low wellbeing as a trait of low socioeconomic status and predictor of problematic drinking, might not only influence healthier attitudes and behaviours regarding alcohol consumption, but also improve self esteem and wellbeing, and encourage school engagement leading to positive educational outcomes. A universal whole-class intervention was developed to target 11-12 year olds, designed to embed into the English secondary personal, social, health and economic education (PSHE) curriculum. The six-week programme of activities took a pupil focused learning approach, drawing upon motivational interviewing and role play amongst other successful components evidenced by the research literature and behavioural theory to encourage intrinsic motivation towards healthier behaviour. Two feasibility studies were conducted in four different school contexts, specifically targeting areas of significant socioeconomic deprivation in the north west of England. Implementation of the intervention and evaluation measures were assessed using a mixed methods research design. Analysis of pre- and post-intervention survey data (matched sample of 89 pupils) and interview transcripts (6 teachers and 20 pupils) revealed broadly successful outcomes. The intervention was considered engaging and enjoyable and was valued by the teachers. One school subsequently chose to deliver the programme for the whole of their new year 7 intake and another school has incorporated elements of the intervention into their PSHE curriculum. These positive outcomes provide the justification to conduct further research to evaluate the effectiveness of participating in the intervention classes when compared to a control group.

Published
2020

6. Differences in ebullitive methane release from small, shallow ponds present challenges for scaling

Author

Baron, A .A. P., Dyck, L. T., Amjad, H., Bragg, J., Kroft, E., Newson, J., Oleson, K., Casson, N. J., North, R. L., Venkiteswaran, J. J., Whitfield., C. J., Baron, A .A. P., Dyck, L. T., Amjad, H., Bragg, J., Kroft, E., Newson, J., Oleson, K., Casson, N. J., North, R. L., Venkiteswaran, J. J., and Whitfield., C. J.

Abstract

Small, shallow waterbodies are potentially important sites of greenhouse gas release to the atmosphere. The role of ebullition may be enhanced here relative to larger and deeper systems, due to their shallow water, but these features remain relatively infrequently studied in comparison to larger systems.Herein,we quantify ebullitive release ofmethane (CH4) in small shallow ponds in three regions of North America and investigate the role of potential drivers. Shallow ponds exhibited open-water season ebullitive CH4 release rates as high as 40 mmol m–2 d–1, higher than previously reported for similar systems. Ebullitive release of CH4 varied by four orders of magnitude across our 15 study sites, with differences in flux rates both within and between regions. What is less clear are the drivers responsible for these differences. There were few relationships between open water–season ebullitive flux and physicochemical characteristics, including organic matter, temperature, and sulphate. Temperature was only weakly related to ebullitive CH4 release across the studywhen considering all observation intervals. Only four individual sites exhibited significant relationships between temperature and ebullitive CH4 release. Other sites were unresponsive to temperature, and region-specific factors may play a role. There is some evidence that where surface water sulphate concentrations are high, CH4 production and release may be suppressed. Missouri sites (n = 5) had characteristically low ebullitive CH4 release; here bioturbation could be important. While this work greatly expands the number of open-water season ebullition rates for small and shallow ponds, more research is needed to disentangle the role of different drivers. Further investigation of the potential thresholding behaviour of sulphate as a control on ebullitive CH4 release in lentic systems is one such opportunity. What is clear, however, is that efforts to scale emissions (e.g., as a function of temperature) must b

Published
2022

8. AusTraits, a curated plant trait database for the Australian flora

Author

Falster, D., Gallagher, R., Wenk, E.H., Wright, I.J., Indiarto, D., Andrew, S.C., Baxter, C., Lawson, J., Allen, S., Fuchs, A., Monro, A., Kar, F., Adams, M.A., Ahrens, C.W., Alfonzetti, M., Angevin, T., Apgaua, D.M.G., Arndt, S., Atkin, O.K., Atkinson, J., Auld, T., Baker, A., von Balthazar, M., Bean, A., Blackman, C.J., Bloomfield, K., Bowman, D.M.J.S., Bragg, J., Brodribb, T. J., Buckton, G., Burrows, G., Caldwell, E., Camac, J., Carpenter, R., Catford, J.A., Cawthray, G.R., Cernusak, L.A., Chandler, G., Chapman, A.R., Cheal, D., Cheesman, A.W., Chen, S-C, Choat, B., Clinton, B., Clode, P.L., Coleman, H., Cornwell, W.K., Cosgrove, M., Crisp, M., Cross, E., Crous, K.Y., Cunningham, S., Curran, T., Curtis, E., Daws, M.I., DeGabriel, J.L., Denton, M.D., Dong, N., Du, P., Duan, H., Duncan, D.H., Duncan, R.P., Duretto, M., Dwyer, J.M., Edwards, C., Esperon-Rodriguez, M., Evans, J.R., Everingham, S.E., Farrell, C., Firn, J., Fonseca, C.R., French, B.J., Frood, D., Funk, J.L., Geange, S.R., Ghannoum, O., Gleason, S.M., Gosper, C.R., Gray, E., Groom, P.K., Grootemaat, S., Gross, C., Guerin, G., Guja, L., Hahs, A.K., Harrison, M.T., Hayes, P.E., Henery, M., Hochuli, D., Howell, J., Huang, G., Hughes, L., Huisman, J., Ilic, J., Jagdish, A., Jin, D., Jordan, G., Jurado, E., Kanowski, J., Kasel, S., Kellermann, J., Kenny, B., Kohout, M., Kooyman, R.M., Kotowska, M.M., Lai, H.R., Laliberté, E., Lambers, H., Lamont, B.B., Lanfear, R., van Langevelde, F., Laughlin, D.C., Laugier-Kitchener, B-A, Laurance, S., Lehmann, C.E.R., Leigh, A., Leishman, M.R., Lenz, T., Lepschi, B., Lewis, J.D., Lim, F., Liu, U., Lord, J., Lusk, C.H., Macinnis-Ng, C., McPherson, H., Magallón, S., Manea, A., López-Martinez, A., Mayfield, M., McCarthy, J.K., Meers, T., van der Merwe, M., Metcalfe, D.J., Milberg, P., Mokany, K., Moles, A.T., Moore, B.D., Moore, N., Morgan, J.W., Morris, W., Muir, A., Munroe, S., Nicholson, Á., Nicolle, D., Nicotra, A.B., Niinemets, Ü., North, T., O’Reilly-Nugent, A., O’Sullivan, O.S., Oberle, B., Onoda, Y., Ooi, M.K.J., Osborne, C.P., Paczkowska, G., Pekin, B., Guilherme Pereira, C., Pickering, C., Pickup, M., Pollock, L.J., Poot, P., Powell, J.R., Power, S.A., Prentice, I.C., Prior, L., Prober, S.M., Read, J., Reynolds, V., Richards, A.E., Richardson, B., Roderick, M.L., Rosell, J.A., Rossetto, M., Rye, B., Rymer, P.D., Sams, M.A., Sanson, G., Sauquet, H., Schmidt, S., Schönenberger, J., Schulze, E-D, Sendall, K., Sinclair, S., Smith, B., Smith, R., Soper, F., Sparrow, B., Standish, R.J., Staples, T.L., Stephens, R., Szota, C., Taseski, G., Tasker, E., Thomas, F., Tissue, D.T., Tjoelker, M.G., Tng, D.Y.P., de Tombeur, F., Tomlinson, K., Turner, N.C., Veneklaas, E.J., Venn, S., Vesk, P., Vlasveld, C., Vorontsova, M.S., Warren, C.A., Warwick, N., Weerasinghe, L.K., Wells, J., Westoby, M., White, M., Williams, N.S.G., Wills, J., Wilson, P.G., Yates, C., Zanne, A.E., Zemunik, G., Ziemińska, K., Falster, D., Gallagher, R., Wenk, E.H., Wright, I.J., Indiarto, D., Andrew, S.C., Baxter, C., Lawson, J., Allen, S., Fuchs, A., Monro, A., Kar, F., Adams, M.A., Ahrens, C.W., Alfonzetti, M., Angevin, T., Apgaua, D.M.G., Arndt, S., Atkin, O.K., Atkinson, J., Auld, T., Baker, A., von Balthazar, M., Bean, A., Blackman, C.J., Bloomfield, K., Bowman, D.M.J.S., Bragg, J., Brodribb, T. J., Buckton, G., Burrows, G., Caldwell, E., Camac, J., Carpenter, R., Catford, J.A., Cawthray, G.R., Cernusak, L.A., Chandler, G., Chapman, A.R., Cheal, D., Cheesman, A.W., Chen, S-C, Choat, B., Clinton, B., Clode, P.L., Coleman, H., Cornwell, W.K., Cosgrove, M., Crisp, M., Cross, E., Crous, K.Y., Cunningham, S., Curran, T., Curtis, E., Daws, M.I., DeGabriel, J.L., Denton, M.D., Dong, N., Du, P., Duan, H., Duncan, D.H., Duncan, R.P., Duretto, M., Dwyer, J.M., Edwards, C., Esperon-Rodriguez, M., Evans, J.R., Everingham, S.E., Farrell, C., Firn, J., Fonseca, C.R., French, B.J., Frood, D., Funk, J.L., Geange, S.R., Ghannoum, O., Gleason, S.M., Gosper, C.R., Gray, E., Groom, P.K., Grootemaat, S., Gross, C., Guerin, G., Guja, L., Hahs, A.K., Harrison, M.T., Hayes, P.E., Henery, M., Hochuli, D., Howell, J., Huang, G., Hughes, L., Huisman, J., Ilic, J., Jagdish, A., Jin, D., Jordan, G., Jurado, E., Kanowski, J., Kasel, S., Kellermann, J., Kenny, B., Kohout, M., Kooyman, R.M., Kotowska, M.M., Lai, H.R., Laliberté, E., Lambers, H., Lamont, B.B., Lanfear, R., van Langevelde, F., Laughlin, D.C., Laugier-Kitchener, B-A, Laurance, S., Lehmann, C.E.R., Leigh, A., Leishman, M.R., Lenz, T., Lepschi, B., Lewis, J.D., Lim, F., Liu, U., Lord, J., Lusk, C.H., Macinnis-Ng, C., McPherson, H., Magallón, S., Manea, A., López-Martinez, A., Mayfield, M., McCarthy, J.K., Meers, T., van der Merwe, M., Metcalfe, D.J., Milberg, P., Mokany, K., Moles, A.T., Moore, B.D., Moore, N., Morgan, J.W., Morris, W., Muir, A., Munroe, S., Nicholson, Á., Nicolle, D., Nicotra, A.B., Niinemets, Ü., North, T., O’Reilly-Nugent, A., O’Sullivan, O.S., Oberle, B., Onoda, Y., Ooi, M.K.J., Osborne, C.P., Paczkowska, G., Pekin, B., Guilherme Pereira, C., Pickering, C., Pickup, M., Pollock, L.J., Poot, P., Powell, J.R., Power, S.A., Prentice, I.C., Prior, L., Prober, S.M., Read, J., Reynolds, V., Richards, A.E., Richardson, B., Roderick, M.L., Rosell, J.A., Rossetto, M., Rye, B., Rymer, P.D., Sams, M.A., Sanson, G., Sauquet, H., Schmidt, S., Schönenberger, J., Schulze, E-D, Sendall, K., Sinclair, S., Smith, B., Smith, R., Soper, F., Sparrow, B., Standish, R.J., Staples, T.L., Stephens, R., Szota, C., Taseski, G., Tasker, E., Thomas, F., Tissue, D.T., Tjoelker, M.G., Tng, D.Y.P., de Tombeur, F., Tomlinson, K., Turner, N.C., Veneklaas, E.J., Venn, S., Vesk, P., Vlasveld, C., Vorontsova, M.S., Warren, C.A., Warwick, N., Weerasinghe, L.K., Wells, J., Westoby, M., White, M., Williams, N.S.G., Wills, J., Wilson, P.G., Yates, C., Zanne, A.E., Zemunik, G., and Ziemińska, K.

Abstract

We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.

Published
2021

9. AusTraits, a curated plant trait database for the Australian flora

Author

Falster, D, Gallagher, R, Wenk, EH, Wright, IJ, Indiarto, D, Andrew, SC, Baxter, C, Lawson, J, Allen, S, Fuchs, A, Monro, A, Kar, F, Adams, MA, Ahrens, CW, Alfonzetti, M, Angevin, T, Apgaua, DMG, Arndt, S, Atkin, OK, Atkinson, J, Auld, T, Baker, A, von Balthazar, M, Bean, A, Blackman, CJ, Bloomfield, K, Bowman, DMJS, Bragg, J, Brodribb, TJ, Buckton, G, Burrows, G, Caldwell, E, Camac, J, Carpenter, R, Catford, JA, Cawthray, GR, Cernusak, LA, Chandler, G, Chapman, AR, Cheal, D, Cheesman, AW, Chen, SC, Choat, B, Clinton, B, Clode, PL, Coleman, H, Cornwell, WK, Cosgrove, M, Crisp, M, Cross, E, Crous, KY, Cunningham, S, Curran, T, Curtis, E, Daws, MI, DeGabriel, JL, Denton, MD, Dong, N, Du, P, Duan, H, Duncan, DH, Duncan, RP, Duretto, M, Dwyer, JM, Edwards, C, Esperon-Rodriguez, M, Evans, JR, Everingham, SE, Farrell, C, Firn, J, Fonseca, CR, French, BJ, Frood, D, Funk, JL, Geange, SR, Ghannoum, O, Gleason, SM, Gosper, CR, Gray, E, Groom, PK, Grootemaat, S, Gross, C, Guerin, G, Guja, L, Hahs, AK, Harrison, MT, Hayes, PE, Henery, M, Hochuli, D, Howell, J, Huang, G, Hughes, L, Huisman, J, Ilic, J, Jagdish, A, Jin, D, Jordan, G, Jurado, E, Kanowski, J, Kasel, S, Falster, D, Gallagher, R, Wenk, EH, Wright, IJ, Indiarto, D, Andrew, SC, Baxter, C, Lawson, J, Allen, S, Fuchs, A, Monro, A, Kar, F, Adams, MA, Ahrens, CW, Alfonzetti, M, Angevin, T, Apgaua, DMG, Arndt, S, Atkin, OK, Atkinson, J, Auld, T, Baker, A, von Balthazar, M, Bean, A, Blackman, CJ, Bloomfield, K, Bowman, DMJS, Bragg, J, Brodribb, TJ, Buckton, G, Burrows, G, Caldwell, E, Camac, J, Carpenter, R, Catford, JA, Cawthray, GR, Cernusak, LA, Chandler, G, Chapman, AR, Cheal, D, Cheesman, AW, Chen, SC, Choat, B, Clinton, B, Clode, PL, Coleman, H, Cornwell, WK, Cosgrove, M, Crisp, M, Cross, E, Crous, KY, Cunningham, S, Curran, T, Curtis, E, Daws, MI, DeGabriel, JL, Denton, MD, Dong, N, Du, P, Duan, H, Duncan, DH, Duncan, RP, Duretto, M, Dwyer, JM, Edwards, C, Esperon-Rodriguez, M, Evans, JR, Everingham, SE, Farrell, C, Firn, J, Fonseca, CR, French, BJ, Frood, D, Funk, JL, Geange, SR, Ghannoum, O, Gleason, SM, Gosper, CR, Gray, E, Groom, PK, Grootemaat, S, Gross, C, Guerin, G, Guja, L, Hahs, AK, Harrison, MT, Hayes, PE, Henery, M, Hochuli, D, Howell, J, Huang, G, Hughes, L, Huisman, J, Ilic, J, Jagdish, A, Jin, D, Jordan, G, Jurado, E, Kanowski, J, and Kasel, S

Abstract

We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.

Published
2021

10. New price list /

Author

Cumberland Valley Nursery Co, Bragg, J. R., Henry G. Gilbert Nursery and Seed Trade Catalog Collection, U.S. Department of Agriculture, National Agricultural Library, Cumberland Valley Nursery Co, Bragg, J. R., and Henry G. Gilbert Nursery and Seed Trade Catalog Collection

Subjects
Berries, Evergreens, Fruit trees, McMinnville, Nurseries (Horticulture), Nursery stock, Plants, Ornamental, Prices, Seedlings, Shrubs, Tennessee, Trees
Published
1930

15. Manufacturing Robustness of CSP in SMT Line

Author

Ghaffarian, R, Chen, A, Romas, N, Bragg, J, Quan, C, Smith, M, and Sterian, I

Abstract

In this paper, the assembly process flow, solder paste for different stencil design, manufacturing defects, X-ray inspection results, and ultrasonic characterizations are reported.

Published
1999

16. Material selection considerations for coaxial, ferrimagnetic-based nonlinear transmission lines.

Author

Bragg, J.-W. B., Dickens, J. C., and Neuber, A. A.

Subjects
*MICROWAVE transmission lines, *FERRIMAGNETISM, *GEOMETRY, *ELECTRIC potential, *BANDWIDTHS, *MAGNETIC fields
Abstract

The growing need for solid-state high power microwave sources has renewed interest in nonlinear transmission lines (NLTLs). This article focuses specifically on ferrimagnetic-based NLTLs in a coaxial geometry. Achieved peak powers exceed 30 MW at 30 kV incident voltage with rf power reaching 4.8 MW peak and pulse lengths ranging from 1-5 ns. The presented NLTL operates in S-band with the capability to tune the center frequency of oscillation over the entire 2-4 GHz band and bandwidths of approximately 30%, placing the NLTL into the ultra-wideband-mesoband category of microwave sources. Several nonlinear materials were tested and the relationship between NLTL performance and material parameters is discussed. In particular, the importance of the material's ferromagnetic resonance linewidth and its relationship to microwave generation is highlighted. For a specific nonlinear material, it is shown that an optimum relation between incident pulse magnitude and static bias magnitude exists. By varying the nonlinear material's bias magnetic field, active delay control was demonstrated. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
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18. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author

Justice, A. E. (Anne E.), Winkler, T. W. (Thomas W.), Feitosa, M. F. (Mary F.), Graff, M. (Misa), Fisher, V. A. (Virginia A.), Young, K. (Kristin), Barata, L. (Llilda), Deng, X. (Xuan), Czajkowski, J. (Jacek), Hadley, D. (David), Ngwa, J. S. (Julius S.), Ahluwalia, T. S. (Tarunveer S.), Chu, A. Y. (Audrey Y.), Heard-Costa, N. L. (Nancy L.), Lim, E. (Elise), Perez, J. (Jeremiah), Eicher, J. D. (John D.), Kutalik, Z. (Zoltan), Xue, L. (Luting), Mahajan, A. (Anubha), Renstrom, F. (Frida), Wu, J. (Joseph), Qi, Q. (Qibin), Ahmad, S. (Shafqat), Alfred, T. (Tamuno), Amin, N. (Najaf), Bielak, L. F. (Lawrence F.), Bonnefond, A. (Amelie), Bragg, J. (Jennifer), Cadby, G. (Gemma), Chittani, M. (Martina), Coggeshall, S. (Scott), Corre, T. (Tanguy), Direk, N. (Nese), Eriksson, J. (Joel), Fischer, K. (Krista), Gorski, M. (Mathias), Harder, M. N. (Marie Neergaard), Horikoshi, M. (Momoko), Huang, T. (Tao), Huffman, J. E. (Jennifer E.), Jackson, A. U. (Anne U.), Justesen, J. M. (Johanne Marie), Kanoni, S. (Stavroula), Kinnunen, L. (Leena), Kleber, M. E. (Marcus E.), Komulainen, P. (Pirjo), Kumari, M. (Meena), Lim, U. (Unhee), Luan, J. (Jian'an), Lyytikäinen, L.-P. (Leo-Pekka), Mangino, M. (Massimo), Manichaikul, A. (Ani), Marten, J. (Jonathan), Middelberg, R. P. (Rita P. S.), Mueller-Nurasyid, M. (Martina), Navarro, P. (Pau), Perusse, L. (Louis), Pervjakova, N. (Natalia), Sarti, C. (Cinzia), Smith, A. V. (Albert Vernon), Smith, J. A. (Jennifer A.), Stancakova, A. (Alena), Strawbridge, R. J. (Rona J.), Stringham, H. M. (Heather M.), Sung, Y. J. (Yun Ju), Tanaka, T. (Toshiko), Teumer, A. (Alexander), Trompet, S. (Stella), van der Laan, S. W. (Sander W.), van der Most, P. J. (Peter J.), Van Vliet-Ostaptchouk, J. V. (Jana V.), Vedantam, S. L. (Sailaja L.), Verweij, N. (Niek), Vink, J. M. (Jacqueline M.), Vitart, V. (Veronique), Wu, Y. (Ying), Yengo, L. (Loic), Zhang, W. (Weihua), Zhao, J. H. (Jing Hua), Zimmermann, M. E. (Martina E.), Zubair, N. (Niha), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Afaq, S. (Saima), Afzal, U. (Uzma), Bakker, S. J. (Stephan J. L.), Bartz, T. M. (Traci M.), Beilby, J. (John), Bergman, R. N. (Richard N.), Bergmann, S. (Sven), Biffar, R. (Reiner), Blangero, J. (John), Boerwinkle, E. (Eric), Bonnycastle, L. L. (Lori L.), Bottinger, E. (Erwin), Braga, D. (Daniele), Buckley, B. M. (Brendan M.), Buyske, S. (Steve), Campbell, H. (Harry), Chambers, J. C. (John C.), Collins, F. S. (Francis S.), Curran, J. E. (Joanne E.), de Borst, G. J. (Gert J.), de Craen, A. J. (Anton J. M.), de Geus, E. J. (Eco J. C.), Dedoussis, G. (George), Delgado, G. E. (Graciela E.), den Ruijter, H. M. (Hester M.), Eiriksdottir, G. (Gudny), Eriksson, A. L. (Anna L.), Esko, T. (Tonu), Faul, J. D. (Jessica D.), Ford, I. (Ian), Forrester, T. (Terrence), Gertow, K. (Karl), Gigante, B. (Bruna), Glorioso, N. (Nicola), Gong, J. (Jian), Grallert, H. (Harald), Grammer, T. B. (Tanja B.), Grarup, N. (Niels), Haitjema, S. (Saskia), Hallmans, G. (Goran), Hamsten, A. (Anders), Hansen, T. (Torben), Harris, T. B. (Tamara B.), Hartman, C. A. (Catharina A.), Hassinen, M. (Maija), Hastie, N. D. (Nicholas D.), Heath, A. C. (Andrew C.), Hernandez, D. (Dena), Hindorff, L. (Lucia), Hocking, L. J. (Lynne J.), Hollensted, M. (Mette), Holmen, O. L. (Oddgeir L.), Homuth, G. (Georg), Hottenga, J. J. (Jouke Jan), Huang, J. (Jie), Hung, J. (Joseph), Hutri-Kähönen, N. (Nina), Ingelsson, E. (Erik), James, A. L. (Alan L.), Jansson, J.-O. (John-Olov), Järvelin, M.-R. (Marjo-Riitta), Jhun, M. A. (Min A.), Jorgensen, M. E. (Marit E.), Juonala, M. (Markus), Kähönen, M. (Mika), Karlsson, M. (Magnus), Koistinen, H. A. (Heikki A.), Kolcic, I. (Ivana), Kolovou, G. (Genovefa), Kooperberg, C. (Charles), Kramer, B. K. (Bernhard K.), Kuusisto, J. (Johanna), Kvaloy, K. (Kirsti), Lakka, T. A. (Timo A.), Langenberg, C. (Claudia), Launer, L. J. (Lenore J.), Leander, K. (Karin), Lee, N. R. (Nanette R.), Lind, L. (Lars), Lindgren, C. M. (Cecilia M.), Linneberg, A. (Allan), Lobbens, S. (Stephane), Loh, M. (Marie), Lorentzon, M. (Mattias), Luben, R. (Robert), Lubke, G. (Gitta), Ludolph-Donislawski, A. (Anja), Lupoli, S. (Sara), Madden, P. A. (Pamela A. F.), Männikkö, R. (Reija), Marques-Vidal, P. (Pedro), Martin, N. G. (Nicholas G.), McKenzie, C. A. (Colin A.), McKnight, B. (Barbara), Mellstrom, D. (Dan), Menni, C. (Cristina), Montgomery, G. W. (Grant W.), Musk, A. W. (A. W. (Bill)), Narisu, N. (Narisu), Nauck, M. (Matthias), Nolte, I. M. (Ilja M.), Oldehinkel, A. J. (Albertine J.), Olden, M. (Matthias), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Peyser, P. A. (Patricia A.), Pisinger, C. (Charlotta), Porteous, D. J. (David J.), Raitakari, O. T. (Olli T.), Rankinen, T. (Tuomo), Rao, D. C. (D. C.), Rasmussen-Torvik, L. J. (Laura J.), Rawal, R. (Rajesh), Rice, T. (Treva), Ridker, P. M. (Paul M.), Rose, L. M. (Lynda M.), Bien, S. A. (Stephanie A.), Rudan, I. (Igor), Sanna, S. (Serena), Sarzynski, M. A. (Mark A.), Sattar, N. (Naveed), Savonen, K. (Kai), Schlessinger, D. (David), Scholtens, S. (Salome), Schurmann, C. (Claudia), Scott, R. A. (Robert A.), Sennblad, B. (Bengt), Siemelink, M. A. (Marten A.), Silbernagel, G. (Gunther), Slagboom, P. E. (P. Eline), Snieder, H. (Harold), Staessen, J. A. (Jan A.), Stott, D. J. (David J.), Swertz, M. A. (Morris A.), Swift, A. J. (Amy J.), Taylor, K. D. (Kent D.), Tayo, B. O. (Bamidele O.), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Tuomilehto, J. (Jaakko), Uitterlinden, A. G. (Andre G.), Vandenput, L. (Liesbeth), Vohl, M.-C. (Marie-Claude), Volzke, H. (Henry), Vonk, J. M. (Judith M.), Waeber, G. (Gerard), Waldenberger, M. (Melanie), Westendorp, R. G. (R. G. J.), Wild, S. (Sarah), Willemsen, G. (Gonneke), Wolffenbuttel, B. H. (Bruce H. R.), Wong, A. (Andrew), Wright, A. F. (Alan F.), Zhao, W. (Wei), Zillikens, M. C. (M. Carola), Baldassarre, D. (Damiano), Balkau, B. (Beverley), Bandinelli, S. (Stefania), Boger, C. A. (Carsten A.), Boomsma, D. I. (Dorret I.), Bouchard, C. (Claude), Bruinenberg, M. (Marcel), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Chines, P. S. (Peter S.), Cooper, R. S. (Richard S.), Cucca, F. (Francesco), Cusi, D. (Daniele), de Faire, U. (Ulf), Ferrucci, L. (Luigi), Franks, P. W. (Paul W.), Froguel, P. (Philippe), Gordon-Larsen, P. (Penny), Grabe, H.-J. (Hans-Jorgen), Gudnason, V. (Vilmundur), Haiman, C. A. (Christopher A.), Hayward, C. (Caroline), Hveem, K. (Kristian), Johnson, A. D. (Andrew D.), Jukema, W. (Wouter), Kardia, S. L. (Sharon L. R.), Kivimäki, M. (Mika), Kooner, J. S. (Jaspal S.), Kuh, D. (Diana), Laakso, M. (Markku), Lehtimäki, T. (Terho), Le Marchand, L. (Loic), Marz, W. (Winfried), McCarthy, M. I. (Mark I.), Metspalu, A. (Andres), Morris, A. P. (Andrew P.), Ohlsson, C. (Claes), Palmer, L. J. (Lyle J.), Pasterkamp, G. (Gerard), Pedersen, O. (Oluf), Peters, A. (Annette), Peters, U. (Ulrike), Polasek, O. (Ozren), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Rauramaa, R. (Rainer), Smith, B. H. (Blair H.), Sorensen, T. I. (Thorkild I. A.), Strauch, K. (Konstantin), Tiemeier, H. (Henning), Tremoli, E. (Elena), Van der Harst, P. (Pim), Vestergaard, H. (Henrik), Vollenweider, P. (Peter), Wareham, N. J. (Nicholas J.), Weir, D. R. (David R.), Whitfield, J. B. (John B.), Wilson, J. F. (James F.), Tyrrell, J. (Jessica), Frayling, T. M. (Timothy M.), Barroso, I. (Ines), Boehnke, M. (Michael), Deloukas, P. (Panagiotis), Fox, C. S. (Caroline S.), Hirschhorn, J. N. (Joel N.), Hunter, D. J. (David J.), Spector, T. D. (Tim D.), Strachan, D. P. (David P.), van Duijn, C. M. (Cornelia M.), Heid, I. M. (Iris M.), Mohlke, K. L. (Karen L.), Marchini, J. (Jonathan), Loos, R. J. (Ruth J. F.), Kilpeläinen, T. O. (Tuomas O.), Liu, C.-T. (Ching-Ti), Borecki, I. B. (Ingrid B.), North, K. E. (Kari E.), Cupples, L. A. (L. Adrienne), Justice, A. E. (Anne E.), Winkler, T. W. (Thomas W.), Feitosa, M. F. (Mary F.), Graff, M. (Misa), Fisher, V. A. (Virginia A.), Young, K. (Kristin), Barata, L. (Llilda), Deng, X. (Xuan), Czajkowski, J. (Jacek), Hadley, D. (David), Ngwa, J. S. (Julius S.), Ahluwalia, T. S. (Tarunveer S.), Chu, A. Y. (Audrey Y.), Heard-Costa, N. L. (Nancy L.), Lim, E. (Elise), Perez, J. (Jeremiah), Eicher, J. D. (John D.), Kutalik, Z. (Zoltan), Xue, L. (Luting), Mahajan, A. (Anubha), Renstrom, F. (Frida), Wu, J. (Joseph), Qi, Q. (Qibin), Ahmad, S. (Shafqat), Alfred, T. (Tamuno), Amin, N. (Najaf), Bielak, L. F. (Lawrence F.), Bonnefond, A. (Amelie), Bragg, J. (Jennifer), Cadby, G. (Gemma), Chittani, M. (Martina), Coggeshall, S. (Scott), Corre, T. (Tanguy), Direk, N. (Nese), Eriksson, J. (Joel), Fischer, K. (Krista), Gorski, M. (Mathias), Harder, M. N. (Marie Neergaard), Horikoshi, M. (Momoko), Huang, T. (Tao), Huffman, J. E. (Jennifer E.), Jackson, A. U. (Anne U.), Justesen, J. M. (Johanne Marie), Kanoni, S. (Stavroula), Kinnunen, L. (Leena), Kleber, M. E. (Marcus E.), Komulainen, P. (Pirjo), Kumari, M. (Meena), Lim, U. (Unhee), Luan, J. (Jian'an), Lyytikäinen, L.-P. (Leo-Pekka), Mangino, M. (Massimo), Manichaikul, A. (Ani), Marten, J. (Jonathan), Middelberg, R. P. (Rita P. S.), Mueller-Nurasyid, M. (Martina), Navarro, P. (Pau), Perusse, L. (Louis), Pervjakova, N. (Natalia), Sarti, C. (Cinzia), Smith, A. V. (Albert Vernon), Smith, J. A. (Jennifer A.), Stancakova, A. (Alena), Strawbridge, R. J. (Rona J.), Stringham, H. M. (Heather M.), Sung, Y. J. (Yun Ju), Tanaka, T. (Toshiko), Teumer, A. (Alexander), Trompet, S. (Stella), van der Laan, S. W. (Sander W.), van der Most, P. J. (Peter J.), Van Vliet-Ostaptchouk, J. V. (Jana V.), Vedantam, S. L. (Sailaja L.), Verweij, N. (Niek), Vink, J. M. (Jacqueline M.), Vitart, V. (Veronique), Wu, Y. (Ying), Yengo, L. (Loic), Zhang, W. (Weihua), Zhao, J. H. (Jing Hua), Zimmermann, M. E. (Martina E.), Zubair, N. (Niha), Abecasis, G. R. (Goncalo R.), Adair, L. S. (Linda S.), Afaq, S. (Saima), Afzal, U. (Uzma), Bakker, S. J. (Stephan J. L.), Bartz, T. M. (Traci M.), Beilby, J. (John), Bergman, R. N. (Richard N.), Bergmann, S. (Sven), Biffar, R. (Reiner), Blangero, J. (John), Boerwinkle, E. (Eric), Bonnycastle, L. L. (Lori L.), Bottinger, E. (Erwin), Braga, D. (Daniele), Buckley, B. M. (Brendan M.), Buyske, S. (Steve), Campbell, H. (Harry), Chambers, J. C. (John C.), Collins, F. S. (Francis S.), Curran, J. E. (Joanne E.), de Borst, G. J. (Gert J.), de Craen, A. J. (Anton J. M.), de Geus, E. J. (Eco J. C.), Dedoussis, G. (George), Delgado, G. E. (Graciela E.), den Ruijter, H. M. (Hester M.), Eiriksdottir, G. (Gudny), Eriksson, A. L. (Anna L.), Esko, T. (Tonu), Faul, J. D. (Jessica D.), Ford, I. (Ian), Forrester, T. (Terrence), Gertow, K. (Karl), Gigante, B. (Bruna), Glorioso, N. (Nicola), Gong, J. (Jian), Grallert, H. (Harald), Grammer, T. B. (Tanja B.), Grarup, N. (Niels), Haitjema, S. (Saskia), Hallmans, G. (Goran), Hamsten, A. (Anders), Hansen, T. (Torben), Harris, T. B. (Tamara B.), Hartman, C. A. (Catharina A.), Hassinen, M. (Maija), Hastie, N. D. (Nicholas D.), Heath, A. C. (Andrew C.), Hernandez, D. (Dena), Hindorff, L. (Lucia), Hocking, L. J. (Lynne J.), Hollensted, M. (Mette), Holmen, O. L. (Oddgeir L.), Homuth, G. (Georg), Hottenga, J. J. (Jouke Jan), Huang, J. (Jie), Hung, J. (Joseph), Hutri-Kähönen, N. (Nina), Ingelsson, E. (Erik), James, A. L. (Alan L.), Jansson, J.-O. (John-Olov), Järvelin, M.-R. (Marjo-Riitta), Jhun, M. A. (Min A.), Jorgensen, M. E. (Marit E.), Juonala, M. (Markus), Kähönen, M. (Mika), Karlsson, M. (Magnus), Koistinen, H. A. (Heikki A.), Kolcic, I. (Ivana), Kolovou, G. (Genovefa), Kooperberg, C. (Charles), Kramer, B. K. (Bernhard K.), Kuusisto, J. (Johanna), Kvaloy, K. (Kirsti), Lakka, T. A. (Timo A.), Langenberg, C. (Claudia), Launer, L. J. (Lenore J.), Leander, K. (Karin), Lee, N. R. (Nanette R.), Lind, L. (Lars), Lindgren, C. M. (Cecilia M.), Linneberg, A. (Allan), Lobbens, S. (Stephane), Loh, M. (Marie), Lorentzon, M. (Mattias), Luben, R. (Robert), Lubke, G. (Gitta), Ludolph-Donislawski, A. (Anja), Lupoli, S. (Sara), Madden, P. A. (Pamela A. F.), Männikkö, R. (Reija), Marques-Vidal, P. (Pedro), Martin, N. G. (Nicholas G.), McKenzie, C. A. (Colin A.), McKnight, B. (Barbara), Mellstrom, D. (Dan), Menni, C. (Cristina), Montgomery, G. W. (Grant W.), Musk, A. W. (A. W. (Bill)), Narisu, N. (Narisu), Nauck, M. (Matthias), Nolte, I. M. (Ilja M.), Oldehinkel, A. J. (Albertine J.), Olden, M. (Matthias), Ong, K. K. (Ken K.), Padmanabhan, S. (Sandosh), Peyser, P. A. (Patricia A.), Pisinger, C. (Charlotta), Porteous, D. J. (David J.), Raitakari, O. T. (Olli T.), Rankinen, T. (Tuomo), Rao, D. C. (D. C.), Rasmussen-Torvik, L. J. (Laura J.), Rawal, R. (Rajesh), Rice, T. (Treva), Ridker, P. M. (Paul M.), Rose, L. M. (Lynda M.), Bien, S. A. (Stephanie A.), Rudan, I. (Igor), Sanna, S. (Serena), Sarzynski, M. A. (Mark A.), Sattar, N. (Naveed), Savonen, K. (Kai), Schlessinger, D. (David), Scholtens, S. (Salome), Schurmann, C. (Claudia), Scott, R. A. (Robert A.), Sennblad, B. (Bengt), Siemelink, M. A. (Marten A.), Silbernagel, G. (Gunther), Slagboom, P. E. (P. Eline), Snieder, H. (Harold), Staessen, J. A. (Jan A.), Stott, D. J. (David J.), Swertz, M. A. (Morris A.), Swift, A. J. (Amy J.), Taylor, K. D. (Kent D.), Tayo, B. O. (Bamidele O.), Thorand, B. (Barbara), Thuillier, D. (Dorothee), Tuomilehto, J. (Jaakko), Uitterlinden, A. G. (Andre G.), Vandenput, L. (Liesbeth), Vohl, M.-C. (Marie-Claude), Volzke, H. (Henry), Vonk, J. M. (Judith M.), Waeber, G. (Gerard), Waldenberger, M. (Melanie), Westendorp, R. G. (R. G. J.), Wild, S. (Sarah), Willemsen, G. (Gonneke), Wolffenbuttel, B. H. (Bruce H. R.), Wong, A. (Andrew), Wright, A. F. (Alan F.), Zhao, W. (Wei), Zillikens, M. C. (M. Carola), Baldassarre, D. (Damiano), Balkau, B. (Beverley), Bandinelli, S. (Stefania), Boger, C. A. (Carsten A.), Boomsma, D. I. (Dorret I.), Bouchard, C. (Claude), Bruinenberg, M. (Marcel), Chasman, D. I. (Daniel I.), Chen, Y. I. (Yii-Der Ida), Chines, P. S. (Peter S.), Cooper, R. S. (Richard S.), Cucca, F. (Francesco), Cusi, D. (Daniele), de Faire, U. (Ulf), Ferrucci, L. (Luigi), Franks, P. W. (Paul W.), Froguel, P. (Philippe), Gordon-Larsen, P. (Penny), Grabe, H.-J. (Hans-Jorgen), Gudnason, V. (Vilmundur), Haiman, C. A. (Christopher A.), Hayward, C. (Caroline), Hveem, K. (Kristian), Johnson, A. D. (Andrew D.), Jukema, W. (Wouter), Kardia, S. L. (Sharon L. R.), Kivimäki, M. (Mika), Kooner, J. S. (Jaspal S.), Kuh, D. (Diana), Laakso, M. (Markku), Lehtimäki, T. (Terho), Le Marchand, L. (Loic), Marz, W. (Winfried), McCarthy, M. I. (Mark I.), Metspalu, A. (Andres), Morris, A. P. (Andrew P.), Ohlsson, C. (Claes), Palmer, L. J. (Lyle J.), Pasterkamp, G. (Gerard), Pedersen, O. (Oluf), Peters, A. (Annette), Peters, U. (Ulrike), Polasek, O. (Ozren), Psaty, B. M. (Bruce M.), Qi, L. (Lu), Rauramaa, R. (Rainer), Smith, B. H. (Blair H.), Sorensen, T. I. (Thorkild I. A.), Strauch, K. (Konstantin), Tiemeier, H. (Henning), Tremoli, E. (Elena), Van der Harst, P. (Pim), Vestergaard, H. (Henrik), Vollenweider, P. (Peter), Wareham, N. J. (Nicholas J.), Weir, D. R. (David R.), Whitfield, J. B. (John B.), Wilson, J. F. (James F.), Tyrrell, J. (Jessica), Frayling, T. M. (Timothy M.), Barroso, I. (Ines), Boehnke, M. (Michael), Deloukas, P. (Panagiotis), Fox, C. S. (Caroline S.), Hirschhorn, J. N. (Joel N.), Hunter, D. J. (David J.), Spector, T. D. (Tim D.), Strachan, D. P. (David P.), van Duijn, C. M. (Cornelia M.), Heid, I. M. (Iris M.), Mohlke, K. L. (Karen L.), Marchini, J. (Jonathan), Loos, R. J. (Ruth J. F.), Kilpeläinen, T. O. (Tuomas O.), Liu, C.-T. (Ching-Ti), Borecki, I. B. (Ingrid B.), North, K. E. (Kari E.), and Cupples, L. A. (L. Adrienne)

Abstract

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

Published
2017

19. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Author

Justice, AE, Winkler, TW, Feitosa, MF, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, JS, Ahluwalia, TS, Chu, AY, Heard-Costa, NL, Lim, E, Perez, J, Eicher, JD, Kutalik, Z, Xue, L, Mahajan, A, Renstrom, F, Wu, J, Qi, QB, Ahmad, Shahzad, Alfred, T, Amin, Najaf, Bielak, LF, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Harder, MN, Horikoshi, M, Huang, T, Huffman, JE, Jackson, AU, Justesen, JM, Kanoni, S, Kinnunen, L, Kleber, ME, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikainen, LP, Mangino, M, Manichaikul, A, Marten, J, Middelberg, RPS, Mueller-Nurasyid, M, Navarro, P, Perusse, L, Pervjakova, N, Sarti, C, Smith, AV, Smith, JA, Stancakova, A, Strawbridge, RJ, Stringham, HM, Sung, YJ, Tanaka, T, Teumer, A, Trompet, S, van der Laan, SW, van der Most, PJ, van Vliet-Ostaptchouk, JV, Vedantam, SL, Verweij, N (Niek), Vink, JM, Vitart, V, Wu, Fenny, Yengo, L, Zhang, WH, Zhao, JH, Zimmermann, ME, Zubair, N, Abecasis, GR, Adair, LS, Afaq, S, Afzal, U, Bakker, SJL, Bartz, TM, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, LL, Bottinger, E, Braga, D, Buckley, BM, Buyske, S, Campbell, H, Chambers, JC, Collins, FS, Curran, JE, de Borst, GJ, de Craen, AJM, de Geus, EJC, Dedoussis, G, Delgado, GE, den Ruijter, HM, Eiriksdottir, G, Eriksson, AL, Esko, T, Faul, JD, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, TB, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, ND, Heath, AC, Hernandez, D, Hindorff, L, Hocking, LJ, Hollensted, M, Holmen, OL, Homuth, G, Hottenga, JJ, Huang, J, Hung, J, Hutri-Kahonen, N, Ingelsson, E, James, AL, Jansson, JO, Jarvelin, MR, Jhun, MA, Jorgensen, ME, Juonala, M, Kahonen, M, Karlsson, M, Koistinen, HA, Kolcic, I, Kolovou, G, Kooperberg, C, Kramer, BK, Kuusisto, J, Kvaloy, K, Lakka, TA, Langenberg, C, Launer, LJ, Leander, K, Lee, NR, Lind, L, Lindgren, CM, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, PAF, Mannikko, R, Marques-Vidal, P, Martin, NG, McKenzie, CA, McKnight, B, Mellstrom, D, Menni, C, Montgomery, GW, Musk, AW, Narisu, N, Nauck, M, Nolte, IM, Oldehinkel, AJ, Olden, M, Ong, KK, Padmanabhan, S, Peyser, PA, Pisinger, C, Porteous, DJ, Raitakari, OT, Rankinen, T, Rao, DC, Rasmussen-Torvik, LJ, Rawal, R, Rice, T, Ridker, PM, Rose, LM, Bien, SA, Rudan, I, Sanna, S, Sarzynski, MA, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, s, Schurmann, C, Scott, RA, Sennblad, B, Siemelink, MA, Silbernagel, G, Slagboom, PE (Eline), Snieder, H, Staessen, JA, Stott, DJ, Swertz, MA, Swift, AJ, Taylor, KD, Tayo, BO, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, André, Vandenput, L, Vohl, MC, Volzke, H, Vonk, JM, Waeber, G, Waldenberger, M, Westendorp, RGJ, Wild, S, Willemsen, G, Wolffenbuttel, BHR, Wong, A, Wright, AF, Zhao, W, Zillikens, M.C., Baldassarre, D, Balkau, B, Bandinelli, S, Boger, CA, Boomsma, DI, Bouchard, C, Bruinenberg, M, Chasman, DI, Chen, YDI, Chines, PS, Cooper, RS, Cucca, F, Cusi, D, de Faire, U, Ferrucci, L, Franks, PW, Froguel, P, Gordon-Larsen, P, Grabe, HJ, Gudnason, V, Haiman, CA, Hayward, C, Hveem, K, Johnson, AD, Jukema, W, Kardia, SLR, Kivimaki, M, Kooner, JS, Kuh, D, Laakso, M, Lehtimaki, T, Le Marchand, L, Marz, W, McCarthy, MI, Metspalu, A, Morris, AP, Ohlsson, C, Palmer, LJ, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, BM, Qi, L, Rauramaa, R, Smith, BH, Sorensen, TIA, Strauch, K, Tiemeier, Henning, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, NJ, Weir, DR, Whitfield, JB, Wilson, JF, Tyrrell, J, Frayling, TM, Barroso, I, Boehnke, M, Deloukas, P, Fox, CS, Hirschhorn, JN, Hunter, DJ, Spector, TD, Strachan, DP, Duijn, Cornelia, Heid, IM, Mohlke, KL, Marchini, J, Loos, RJF, Kilpelainen, TO, Liu, CT, Borecki, IB, North, KE, Cupples, LA, Justice, AE, Winkler, TW, Feitosa, MF, Graff, M, Fisher, V A, Young, K, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, JS, Ahluwalia, TS, Chu, AY, Heard-Costa, NL, Lim, E, Perez, J, Eicher, JD, Kutalik, Z, Xue, L, Mahajan, A, Renstrom, F, Wu, J, Qi, QB, Ahmad, Shahzad, Alfred, T, Amin, Najaf, Bielak, LF, Bonnefond, A, Bragg, J, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Harder, MN, Horikoshi, M, Huang, T, Huffman, JE, Jackson, AU, Justesen, JM, Kanoni, S, Kinnunen, L, Kleber, ME, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikainen, LP, Mangino, M, Manichaikul, A, Marten, J, Middelberg, RPS, Mueller-Nurasyid, M, Navarro, P, Perusse, L, Pervjakova, N, Sarti, C, Smith, AV, Smith, JA, Stancakova, A, Strawbridge, RJ, Stringham, HM, Sung, YJ, Tanaka, T, Teumer, A, Trompet, S, van der Laan, SW, van der Most, PJ, van Vliet-Ostaptchouk, JV, Vedantam, SL, Verweij, N (Niek), Vink, JM, Vitart, V, Wu, Fenny, Yengo, L, Zhang, WH, Zhao, JH, Zimmermann, ME, Zubair, N, Abecasis, GR, Adair, LS, Afaq, S, Afzal, U, Bakker, SJL, Bartz, TM, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, LL, Bottinger, E, Braga, D, Buckley, BM, Buyske, S, Campbell, H, Chambers, JC, Collins, FS, Curran, JE, de Borst, GJ, de Craen, AJM, de Geus, EJC, Dedoussis, G, Delgado, GE, den Ruijter, HM, Eiriksdottir, G, Eriksson, AL, Esko, T, Faul, JD, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, TB, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, ND, Heath, AC, Hernandez, D, Hindorff, L, Hocking, LJ, Hollensted, M, Holmen, OL, Homuth, G, Hottenga, JJ, Huang, J, Hung, J, Hutri-Kahonen, N, Ingelsson, E, James, AL, Jansson, JO, Jarvelin, MR, Jhun, MA, Jorgensen, ME, Juonala, M, Kahonen, M, Karlsson, M, Koistinen, HA, Kolcic, I, Kolovou, G, Kooperberg, C, Kramer, BK, Kuusisto, J, Kvaloy, K, Lakka, TA, Langenberg, C, Launer, LJ, Leander, K, Lee, NR, Lind, L, Lindgren, CM, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, PAF, Mannikko, R, Marques-Vidal, P, Martin, NG, McKenzie, CA, McKnight, B, Mellstrom, D, Menni, C, Montgomery, GW, Musk, AW, Narisu, N, Nauck, M, Nolte, IM, Oldehinkel, AJ, Olden, M, Ong, KK, Padmanabhan, S, Peyser, PA, Pisinger, C, Porteous, DJ, Raitakari, OT, Rankinen, T, Rao, DC, Rasmussen-Torvik, LJ, Rawal, R, Rice, T, Ridker, PM, Rose, LM, Bien, SA, Rudan, I, Sanna, S, Sarzynski, MA, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, s, Schurmann, C, Scott, RA, Sennblad, B, Siemelink, MA, Silbernagel, G, Slagboom, PE (Eline), Snieder, H, Staessen, JA, Stott, DJ, Swertz, MA, Swift, AJ, Taylor, KD, Tayo, BO, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, André, Vandenput, L, Vohl, MC, Volzke, H, Vonk, JM, Waeber, G, Waldenberger, M, Westendorp, RGJ, Wild, S, Willemsen, G, Wolffenbuttel, BHR, Wong, A, Wright, AF, Zhao, W, Zillikens, M.C., Baldassarre, D, Balkau, B, Bandinelli, S, Boger, CA, Boomsma, DI, Bouchard, C, Bruinenberg, M, Chasman, DI, Chen, YDI, Chines, PS, Cooper, RS, Cucca, F, Cusi, D, de Faire, U, Ferrucci, L, Franks, PW, Froguel, P, Gordon-Larsen, P, Grabe, HJ, Gudnason, V, Haiman, CA, Hayward, C, Hveem, K, Johnson, AD, Jukema, W, Kardia, SLR, Kivimaki, M, Kooner, JS, Kuh, D, Laakso, M, Lehtimaki, T, Le Marchand, L, Marz, W, McCarthy, MI, Metspalu, A, Morris, AP, Ohlsson, C, Palmer, LJ, Pasterkamp, G, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, BM, Qi, L, Rauramaa, R, Smith, BH, Sorensen, TIA, Strauch, K, Tiemeier, Henning, Tremoli, E, van der Harst, P, Vestergaard, H, Vollenweider, P, Wareham, NJ, Weir, DR, Whitfield, JB, Wilson, JF, Tyrrell, J, Frayling, TM, Barroso, I, Boehnke, M, Deloukas, P, Fox, CS, Hirschhorn, JN, Hunter, DJ, Spector, TD, Strachan, DP, Duijn, Cornelia, Heid, IM, Mohlke, KL, Marchini, J, Loos, RJF, Kilpelainen, TO, Liu, CT, Borecki, IB, North, KE, and Cupples, LA

Published
2017

31. Ik Kan, Ik Wil, Ik Doe: Zelfbeeld en Gedragsproblemen bij Volwassenen met een Licht Verstandelijke Beperking

Author

Bragg, J., Lieshout, K.H.J. van (Thesis Advisor), Douma, J.C.H., Bragg, J., Lieshout, K.H.J. van (Thesis Advisor), and Douma, J.C.H.

Abstract

Het doel van het huidige onderzoek is om na te gaan of er een samenhang is tussen het zelfbeeld en internaliserend en externaliserend probleemgedrag bij volwassenen met een licht verstandelijke beperkingen [LVB]. Onderzoek heeft aangetoond dat het zelfbeeld van invloed is op de mate van internaliserend en externaliserend probleemgedrag, maar er is weinig onderzoek gedaan naar deze relatie bij volwassenen met een LVB. Zelfbeeld is ten behoeve van het onderzoek onderverdeeld in zelfvertrouwen en competentiebeleving. Methode: Respondenten zijn woonachtig binnen een instelling voor mensen met verstandelijke beperkingen en zijn aselect geworven, via een enkelvoudige steekproef (N = 25). De steekproef bestond uit 15 mannen (Mleeftijd = 25.27, SD = 5.52) en 10 vrouwen (Mleeftijd = 23.80, SD = 3.52). Een leeftijd tussen de 18 en 35 jaar oud, aanwezigheid van een licht verstandelijke beperking en beheersing van de Nederlandse taal vielen onder de inclusiecriteria. De samenhang tussen de afhankelijke en onafhankelijke variabelen zijn middels multipele regressie analyses onderzocht. Resultaten: Uit het onderzoek komt naar voren dat er een significante, positieve samenhang is tussen de mate van zelfvertrouwen en externaliserend probleemgedrag (p = .042). Er is geen samenhang gevonden tussen competentiebeleving en internaliserend of externaliserend probleemgedrag, en zelfvertrouwen en internaliserend probleemgedrag. Conclusie: De vrijwillige aard van deelname aan het onderzoek trekt de representativiteit van de steekproef in twijfel. Bovendien is het, gezien de kleine steekproef, van belang om vervolgonderzoek te doen naar zelfbeeld en gedragsproblemen binnen de doelgroep, om de samenhang tussen zelfvertrouwen en externaliserend probleemgedrag nader te onderzoeken.

Published
2015

32. Opportunities for improving phosphorus-use efficiency in crop plants

Author

Veneklaas, EJ, Lambers, H, Bragg, J, Finnegan, PM, Lovelock, CE, Plaxton, WC, Price, CA, Scheible, WR, Shane, MW, White, PJ, and Raven, JA

Subjects
Plant Leaves, Crops, Agricultural, Reproduction, Plant Biology & Botany, food and beverages, Phosphorus, Photosynthesis, Phylogeny
Abstract

Limitation of grain crop productivity by phosphorus (P) is widespread and will probably increase in the future. Enhanced P efficiency can be achieved by improved uptake of phosphate from soil (P-acquisition efficiency) and by improved productivity per unit P taken up (P-use efficiency). This review focuses on improved P-use efficiency, which can be achieved by plants that have overall lower P concentrations, and by optimal distribution and redistribution of P in the plant allowing maximum growth and biomass allocation to harvestable plant parts. Significant decreases in plant P pools may be possible, for example, through reductions of superfluous ribosomal RNA and replacement of phospholipids by sulfolipids and galactolipids. Improvements in P distribution within the plant may be possible by increased remobilization from tissues that no longer need it (e.g. senescing leaves) and reduced partitioning of P to developing grains. Such changes would prolong and enhance the productive use of P in photosynthesis and have nutritional and environmental benefits. Research considering physiological, metabolic, molecular biological, genetic and phylogenetic aspects of P-use efficiency is urgently needed to allow significant progress to be made in our understanding of this complex trait. © 2012 The Authors. New Phytologist © 2012 New Phytologist Trust.

Published
2012

40. The evolution of protein material costs

Author

Caetano-Anolles, G, Caetano-Anolles, G ( G ), Bragg, J G, Wagner, A, Caetano-Anolles, G, Caetano-Anolles, G ( G ), Bragg, J G, and Wagner, A

Published
2010

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