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22 results on '"Braganca, Jose"'

1. Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials

Author

Andrade, Raquel P., Calado, Sofia, Faleiro, Maria Leonor, Matos, Carlos, Marques, Nuno, Marreiros, Ana, Nzwalo, Hipólito, Pais, Sandra, Palmeirim, Isabel, Simão, Sónia, Joaquim, Natércia, Miranda, Rui, Pêgas, António, Raposo, Daniela Marques, Sardo, Ana, Esteves, Filipa, Brito, David, Rajado, Ana Teresa, Silva, Nádia, Apolónio, Joana, Roberto, Vânia Palma, Araújo, Inês, Nóbrega, Clévio, Castelo-Branco, Pedro, and Bragança, José

Published
2023
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5. SERUM LIPID PROFILE, HEPATIC FUNCTION AND MILK PRODUCTION IN COWS SUPPLEMENTED WITH BOVINE RECOMBINANT SOMATOTROPIN/LIPIDOGRAMA, FUNCAO HEPATICA E PRODUCAO DE LEITE EM VACAS SUPLEMENTADAS COM SOMATOTROPINA RECOMBINANTE BOVINA/PERFIL DE LIPIDOS SERICOS, FUNCION HEPATICA Y PRODUCCION DE LECHE EN VACAS SUPLEMENTADAS CON SOMATOTROPINA BOVINA RECOMBINANTE

Author

Signor, Daniel, Piva, Gustavo Dal, Huf, Lucas, Fiorentin, Eliana, Immich, Brayan, Rocha, Jose Francisco, Leal, Marta Lizandra, Braganca, Jose Francisco, and Rocha, Ricardo Xavier

Published
2017

6. RUMEN PROTECTED CHOLINE AND ITS EFFECT ON THE PREVENTION OF PREGNANCY TOXEMIA IN DAIRY EWES/COLINA PROTEGIDA DA DEGRADACAO RUMINAL E SEU EFEITO NA PREVENCAO DA TOXEMIA DA GESTACAO EM OVELHAS LEITEIRAS/COLINA PROTEGIDA DE LA DEGRADACION RUMINAL Y SU EFECTO EN LA PREVENCION DE LA TOXEMIA DE LA GESTACION EN OVEJAS LECHERAS

Author

Michailoff, Andressa Alaine, Agnol, Dom Diego Dall, Bianchi, Anderson Elias, Balistieri, Fabiano Samuel, Fiorentin, Eliana Lucia, Rocha, Ricardo Xavier, and Braganca, Jose Francisco Manta

Published
2017

7. From fibroblasts to cardiomyocytes and beyond

Author

Duarte, Ana J., Ribeiro, Diogo, Braganca, Jose, and Amaral, Olga

Subjects
Cardiomyocytes, iPSC, Fabry Disease, Human Genetics, Prime-editing, Cell Models, Doenças Genéticas
Abstract

This oral presentation was part of the PhD project of A.J. Duarte at ICBAS (UP). From Fabry disease causing effect to personalised cell model of cardiomyocytes and future mutation correction applying a prime-editing approach. CECA, INSA, and also funded by the Fundação para a Ciência e Tecnologia: (FCT) Project Grant: PTDC/BIM MEC/4762/2014 (2016) info:eu-repo/semantics/publishedVersion

Published
2022

8. Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research

Author

Esteves, Filipa, Brito, David, Rajado, Ana Teresa, Silva, Nádia, Apolónio, Joana, Roberto, Vânia Palma, Andrade, Raquel P., Calado, Sofia, Faleiro, Maria Leonor, Matos, Carlos, Marques, Nuno, Marreiros, Ana, Nzwalo, Hipólito, Pais, Sandra, Palmeirim, Isabel, Simãoa, Sónia, Joaquim, Natércia, Miranda, Rui, Pêgas, António, Raposo, Daniela Marques, Sardo, Ana, Araújo, Inês, Nóbrega, Clévio, Castelo-Branco, Pedro, and Bragança, José

Published
2024
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12. Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants

Author

Santos, Joao M. A., Mendes-Silva, Leonardo, Afonso, Vanessa, Martins, Gil, Machado, Rui S. R., Lopes, Joao A., Cancela, Leonor, Futschik, Matthias E., Sachinidis, Agapios, Gavaia, Paulo, Braganca, Jose, Santos, Joao M. A., Mendes-Silva, Leonardo, Afonso, Vanessa, Martins, Gil, Machado, Rui S. R., Lopes, Joao A., Cancela, Leonor, Futschik, Matthias E., Sachinidis, Agapios, Gavaia, Paulo, and Braganca, Jose

Abstract

Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs cardiac differentiation. We have now determined that Cited2 depletion in ESC affects the expression of transcription factors and cardiopoietic genes involved in early mesoderm and cardiac specification. Interestingly, the supplementation of the secretome prepared from ESC overexpressing CITED2, during the onset of differentiation, rescued the cardiogenic defects of Cited2-depleted ESC. In addition, we demonstrate that the proteins WNT5A and WNT11 held the potential for rescue. We also validated the zebrafish as a model to investigate cited2 function during development. Indeed, the microinjection of morpholinos targeting cited2 transcripts caused developmental defects recapitulating those of mice knockout models, including the increased propensity for cardiac defects and severe death rate. Importantly, the co-injection of anti-cited2 morpholinos with either CITED2 or WNT5A and WNT11 recombinant proteins corrected the developmental defects of Cited2-morphants. This study argues that defects caused by the dysfunction of Cited2 at early stages of development, including heart anomalies, may be remediable by supplementation of exogenous molecules, offering the opportunity to develop novel therapeutic strategies aiming to prevent CHD.

Published
2019

13. List of contributors

Author

Amaral, Olga, Bertini, Enrico, Bragança, José, Cagavi, Esra, Compagnucci, Claudia, Duarte, Ana, Gingold, Julian A., Giri, Subhajit, Huang, Mo-Fan, Iyer, Shilpa, Jang, Yoon-Young, Lee, Dung-Fang, Lowenthal, Justin, Malgrange, Brigitte, Meshrkey, Fibi, Morizane, Ryuji, Mutlu Burnaz, Ozlem, Pang, Lon Kai, Pena, Mezthly, Rao, Raj R., Ribeiro, Diogo, Santos, Renato, Tartaglia, Marco, Tomaselli, Gordon F., Traitteur, Tamara, Tung, Leslie, Ulrichs, Heidi, Wang, Yichen, West, Franklin D., Wu, Hsueh Fu, Yang, Brenda, Zeltner, Nadja, Zhang, Chengcheng, and Zhao, Ruiying

Published
2022
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18. Bioelectrical Signal Detection Using Conducting Polymer Electrodes and the Displacement Current Method

Author

Inacio, Pedro M. C., primary, Mestre, Ana L. G., additional, de Medeiros, Maria do Carmo Raposo, additional, Asgarifar, Sanaz, additional, Elamine, Youssef, additional, Canudo, Joana, additional, Santos, Joao M. A., additional, Braganca, Jose, additional, Morgado, Jorge, additional, Biscarini, Fabio, additional, and Gomes, Henrique Leonel, additional

Published
2017
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20. Functional Significance of SRJ Domain Mutations in CITED2

Author

Chen, Chiann-mun, primary, Bentham, Jamie, additional, Cosgrove, Catherine, additional, Braganca, Jose, additional, Cuenda, Ana, additional, Bamforth, Simon D., additional, Schneider, Jürgen E., additional, Watkins, Hugh, additional, Keavney, Bernard, additional, Davies, Benjamin, additional, and Bhattacharya, Shoumo, additional

Published
2012
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22. CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells

Author

Pacheco-Leyva, Ivette, Matias, Ana Catarina, Oliveira, Daniel V., Santos, João M.A., Nascimento, Rita, Guerreiro, Eduarda, Michell, Anna C., van De Vrugt, Annebel M., Machado-Oliveira, Gisela, Ferreira, Guilherme, Domian, Ibrahim, and Bragança, José

Subjects
transcriptional regulation, cardiac progenitor, Cited2, Isl1, embryonic stem cell, differentiation
Abstract

Summary The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC). The overexpression of CITED2 in undifferentiated ESC was sufficient to promote cardiac cell emergence upon differentiation. Conversely, the depletion of Cited2 at the onset of differentiation resulted in a decline of ESC ability to generate cardiac cells. Moreover, loss of Cited2 expression impairs the expression of early mesoderm markers and cardiogenic transcription factors (Isl1, Gata4, Tbx5). The cardiogenic defects in Cited2-depleted cells were rescued by treatment with recombinant CITED2 protein. We showed that Cited2 expression is enriched in cardiac progenitors either derived from ESC or mouse embryonic hearts. Finally, we demonstrated that CITED2 and ISL1 proteins interact physically and cooperate to promote ESC differentiation toward cardiomyocytes. Collectively, our results show that Cited2 plays a pivotal role in cardiac commitment of ESC.

Published
2016
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